The fact that you can get a borderline miraculous vaccine at basically any drug store at the cost of 20 minutes of your time and that would basically end the pandemic and yet people aren't doing it drives me absolutely, totally, completely crazy
No Twitter I don't want to read preprints before I retweet them. I'm not retweeting them because of the content, I'm retweeting them because my homie posted a new paper and I'm trying to be a bro.
In contrast to a common thought on Twitter, I think you should NOT do a PhD (or a postdoc) unless you are really intrinsically motivated by the topic. There's just too much opportunity cost: if you are just looking for a good work environment, go make a lot more money in industry
Terrible decision by
@eLife
to get rid of one of the people most dedicated to the journal's stated mission for the crime of being concerned about the loss of civilian life
I have been informed that I am being replaced as the Editor in Chief of
@eLife
for retweeting a
@TheOnion
piece that calls out indifference to the lives of Palestinian civilians.
One of the only positive things about covid is that it has convinced me that evolutionary biology is, in fact, actually useful, and not merely interesting.
Hot take: I feel like the "my success is mostly due to luck" aspect of imposter syndrome 1) is almost certainly true for almost everybody and 2) would make the world a better place if more people realized it
Pretty convinced linear algebra is basically the most important math you can know. Combine linear algebra with just a touch of calculus and you've got so much power.
A PhD isn't job training. It's a JOB. We should treat PhD students like employees, which includes mentorship to help them get the skills they need to pursue their career goals.
@Constababble
PhDs aren't job training. They're an exceptionally deep-dive research experience. My view is that too many people who don't actually want that experience are pursuing PhDs because they don't know of another option for advanced training. A new MSc would fix that.
My team at Illumina has been hiring like crazy for the last couple months and for some reason I was stupid and didn't post about it on Twitter. We're looking for anyone in the broad field of understanding what genomes do. If you're interested in talking about it, my DMs are open!
@sebatlab
This happens in literally every job. Industry trains people too. Do you think someone coming out of a bachelor's with a CS degree needs less training than a PhD? And it's not about temporary vs staff, the average time in a tech job is like 2 years, shorter than most postdocs
This is something that so many faculty don't understand. If you work weekends, holidays, and send e-mails at 2am, you're setting an example. You're implicitly saying that this is what it takes to be successful. You have power and influence, whether you want to admit it or not.
As new grad students, we don’t know what is “Normal” or not. We’re afraid to not fit in, or be enough.
We need faculty & deans to change the culture & hold toxic colleagues accountable. The onus should not be all on the students.
New study finds pay is the most important factor limiting undergraduate students from underrepresented backgrounds' willingness to take environment and natural resource internships.
Proud to be welcoming 3 paid undergrads this summer to our lab!
I actually think this has a lot of truth to it. If you want to impact the world, you should absolutely be in industry or government. Academia is for somehow getting paid to do a bunch of stuff that doesn't matter
As academia became more competitive, high-achiever types flocked to it & outperformed the weirdos who used to populate it; the result is widespread unhappiness, bc academia is more suited to ppl who obsess over Aristotle's theory of sleep than ppl who want to change the world.
How about we do this so that fucking graduate students don't have to give out interest free loans to universities when they register and book travel and accommodation for conferences?
Google discovered that giving every employee a credit card and trusting them to follow policy on expenses, even with some bad actors, was cheaper than the enforcement and structures most companies use.
How much do you waste due to low trust? Can you do the math for your company?
@existentialcoms
Incredibly bad take. There *literally is* a shortage of housing in some places. As an extreme example, Palo Alto has added like 10 jobs for every home it's added. That's a housing shortage, plain and simple.
@CarlOrkmansen
You realize you're showing that the unit *is in fact rented* right? Your example *literally shows that it gets rented*. Obviously you can make money on the margin by doing something like this in a shortage. The solution is *not having a shortage*.
Some personal news: today is my last day at Ancestry. I've learned a lot and been fortunate to work with some amazing people here, and I'll miss it a lot.
I'm moving on to a new opportunity at Illumina, developing tools for making the most out of whole genome data!
Since Twitter's about to go away, it seems like a good time to say that starting January, I'm going to try to grind my way back into academia! I'll be starting as a research scientist joint with
@DocEdge85
and
@mwpen
at USC, working on... well, a bunch of stuff
I can't believe how dumb and bootlicky this is going to sound, but one of the best differences between academia and industry is that industry has HR departments that take things seriously.
Excited to share this preprint with
@DocEdge85
! We wanted to ask what you can learn how genetics explains between-group differences if you know how much genetics explains within-group differences. Turns out the answer is almost nothing! 1/
Excited to share this preprint with
@DocEdge85
! We wanted to ask what you can learn how genetics explains between-group differences if you know how much genetics explains within-group differences. Turns out the answer is almost nothing! 1/
@bballbreakdown
Wow these are bad! And honestly you're being generous with some of the ones you say you'd let slide. Multiple possessions where he travels 3 or 4 times...
I suspect that millennials (and late gen-x) are probably the most computer literate on average, due to coming of age in a time when computers were important and common, but they weren't quite as user friendly as they are now, where you don't have to understand anything about them
@ezraklein
Honestly, I'm a geneticist and I think that CRISPR for this kind of thing is incredibly overhyped. The vast majority of the utility of CRISPR in the short to medium term is just going to be in basic molecular biology research. Useful, at scale human gene therapy is still far off
@mackcaple
Wow, I feel like application fees went up a LOT since I applied. I don't remember paying more than 100 for any. Although obviously all application fees are absurd and ridiculous and should be abolished.
Every time I write a python script, I have to go back to an old script of mine to remember how to set up argparse. For some reason it just does not stick in my mind AT ALL.
Always sorta blows my mind that something as dumb as maximum likelihood works. "Gee what if I just choose the value of the parameter that makes the data the most probable." Seems like cheating tbh
Today's my last day at Illumina! Monday is my first day working with
@DocEdge85
and
@mwpen
at USC! I don't recommend only taking a weekend off between jobs but due to some stupid circumstances this is just what worked out. Excited to work on a bunch of interesting evolution!
@existentialcoms
And no,"let's forcibly move homeless people to the middle of nowhere so they can live in a dilapidated empty house" is not a progressive take
@moultano
@mnolangray
Disagree so much. Going to work is depressing if sun is out or not. If sun is gone when I finally get home it truly makes the day feel wasted
@the_transit_guy
Too lazy to make it, but imagine I made a "Don't make me tap the sign" meme with the heat map showing how much lower CO2 per capita is in urban areas
This is one of those sentiments that sounds progressive but ends up being the opposite. It’s worse for workers to have to rely on their employers to play the role of the welfare state
For the love of god pay for postdocs' moving expenses. Do you really think they have thousands of dollars saved up to move across the country after being a *grad student*
Can someone explain to me why, despite the fact that I measure the oats and water with a measuring cup, my oatmeal comes out a totally different consistency every morning
Does anyone besides me think that dn/ds is a sort of weird metric of positive selection? It seems like a very specific mode of adaptation to fix multiple amino acids substitutions in the same protein in a short period of time
Thesis: many of life's common pains can be alleviated by working out and being more active
Antithesis: working out results in injuries and chronic pain in its own right
Synthesis: life is pain
@redditships
This rules and I don't see any reason that this guy *has to be* ambitious at work. Assuming he's actually taking on most of the household labor since her job is stressful, I genuinely don't see a problem here
I wonder how much of the lack of conservative ideology in academic positions is that, frankly, a lot of conservative positions are basically wrong. As an extreme example, it'd be absurd to have a creationist in a biology department. We're not lacking diversity because of that.
I find the UAustin ridicule cringeworthy. The fact that I’m at a leading policy school at one of the more “freethinking” places and I can’t think of a single conservative on the faculty (and a handful—at most—in our other professional schools) ought to be deeply concerning.
Ice cold take: this paper should be required reading for anyone studying quantitative phenotypes, whether they're explicitly an evolutionary biologist or not
I'm really excited to share this manuscript describing the guts behind our ancestry inference algorithm. This is great work that's gone on since way before I joined Ancestry, and I was super excited to get an opportunity to be a (small) part of this!
@TonyManfredonia
@scully1888
This is amazing. It HAS to be intentional right? A tritone and a half step are basically optimally chosen to be as dissonant as possible. I honestly think it kinda rules
The undergraduate statistics class I took was an absolute disaster and I think it was representative of many similar classes. Just a litany of statistical tests, absolutely no understanding. Teaching stats without a grounding in probability just isn't worth it, in my opinion.
This is obviously true and the key reason is variety. One of the most annoying things about traveling in any one European country is that you just get sick of eating their national cuisine and finding any variety that's not awful is very difficult
The central limit theorem. It's the only thing that occasionally makes me question my atheism. How did we get so lucky to live in a universe where the central limit theorem is true???
I honestly don't understand why people are so up in arms about the new
@eLife
model. If you don't like it, don't publish there. You can still submit your paper to plenty of glossy journals.
I always point out that the early pioneers of statistical genetics (particularly Galton and Fisher) were huge racists, and arguably motivated in their studies by racism. We do a disservice to our students if we don't emphasize that these "great men" were also vile on many levels.
@LinkofSunshine
I honestly don't know which definition the tweet is complaining about. The first definition is how the word is used in casual conversation, and the second is the more strict Marxist definition! What's the issue???
Fisher's contributions to science are hard to overstate.
But we do a disservice when we neglect to mention that he was a horrible person, a eugenicist, a racist, a misogynist, and went to his grave arguing that smoking didn't cause cancer.
Fisher is often celebrated as a statistician and for good reason. Most of what we do today wouldn’t exist without him. It’s odd that he is not so well-known for his work in biology. Without him our understanding of Genetics would not be the same.
People on my timeline talking about EA (educational attainment) and EA (effective altruism) is almost as bad as people talking about IBD (isolation by distance), IBD (irritable bowel disorder) and IBD (identity by descent)
@HillaryRonen
Yeah, if you're opposed to GMO food, you're not pro-food. Genetically modified food is a key tool for the future of agriculture to improve yields and survive disease. Not to mention, it's probably safer than traditional breeding in many ways.
I see so many late stage grad students who have been convinced by academia that they don't have any skills and that they need to do a postdoc because they won't be competitive for non-academic jobs without them. This is almost always wrong
2) Skilled workers are in high demand. I talked to several Astronomers who thought it impossible to switch to Tech because they "lack" skills. Let me tell you: you know how to program, you know maths, you can write, you can give presentations. You ARE highly skilled. 3/n
@besttrousers
I thought pseudoephedrine was more for congestion than sore throats? Also, at least as of the last time I needed it, you can get it by asking the pharmacist in California.
Maximum-likelihood modelling and machine learning favour a scenario of multiple admixture events over the long-term between
#Neanderthals
and modern humans, find
@FerVillanea
&
@jgschraiber
Free-to-read:
Can I suggest we just use the acronym PGS for Polygenic Score instead of PRS? The word "risk" though it has a basically precise statistical definition has a terrible connotation in general parlance.
#ASHG19
I really strongly recommend to basically every scientist that they should take a probability course. The kind that teaches you how to calculate expectations and do change of variables. It's unironically life changing to have even a surface level understanding of probability
Attention all biology PhD applicants: Take 2 programming courses and a probability course (this is not the same thing as statistics) BEFORE you get to grad school. This may or may not help you get into a PhD program, but it will help you once you start. You will not regret it.
This is obviously stupid. Elite athletes are all already genetic abnormalities. Should they have banned Michael Phelps because he has a 99.9th percentile sitting height to standing height ratio? Let's just ban every repeat winner, they obviously have an unfair advantage!
Namibia's Christine Mboma and Beatrice Masilingi have been withdrawn from the 400m race at the Olympics by World Athletics.
They are said to not be eligible for female classification.
The same rules are affecting Caster Semenya, Francine Niyonsaba and Margaret Wambui.
@lemon_lymann
@redditships
A lot of jobs, especially office jobs, are dumb and don't actually require very much work. I'd bet that a lot of his co-workers are also spending a lot of time chilling to be honest
Note: I definitely don't mean that people aren't good at what they succeeded at, but rather than most people aren't SO MUCH BETTER than everyone else at what they do that it explains their success vs. others failure
What's the chance we accidentally eradicate other infectious diseases during this sheltering in place? I feel like lots of them have R0 much smaller than COVID-19.
@anthonyVslater
This is one FIBA rule I'm not sure about. Most of the FIBA rules seem better tbh, especially as far as fast breaks, but I like to see those wild shots that roll and bounce
Some people know this already but with SMBE coming up I figure it's time for a fully public announcement: starting January 2019 I'll be taking a leave of absence from Temple to explore opportunities in industry and move back to the West Coast 1/
@DaveOshry
I'm traumatized by that shit. I got stuck in there because I was a stealth character and the trolls level scaled to be able to beat my ass down if I tried to actually fight them. I was just stuck inside the fucking painting.
I think a good summary of Mike Lynch's talk is that eukaryotes have incredibly complex cellular machinery, but still perform these tasks way worse than bacteria. So this points toward non-adaptive evolution of complexity, and we have some models in some cases
#SMBE2023