Nathan Pearson @GenomeNathan Twitter profile

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Nathan Pearson

2 years

New talk, from the heart...on what #DNA teaches us about history, sharing, and how to secure a justly equitable future.

The splendid tapestry: How DNA reveals truths, ancient & lasting |...

Amid global ethnic and political strife, can DNA help settle questions of history, diversity, and rights?Can doing so challenge assumptions on how to secure ...

www.youtube.com

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Nathan Pearson

@GenomeNathan

10 months

1/Holy shit. RFK Jr. intimates SARS-CoV2 was somehow a bioweapon...to target 'Caucasians & Black people' but spare 'Chinese people & Ashkenazi Jews'. We 1000s geneticists worldwide who teamed to learn how human DNA shapes COVID (…) can call -bullshit-.

Mapping the human genetic architecture of COVID-19

Nature - A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and...

www.nature.com

Oliver Darko

@oliver_drk

10 months

@nypost When Robert F Kennedy Jr claims covid was genetically engineered to spare “Jews and Chinese people” you can literally see how uncomfortable his campaign team gets.

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Nathan Pearson

@GenomeNathan

2 years

Good people, our #NobelPrize2022 laureate Svante Pääbo, doing a task most senior scientists deem gruntwork for juniors: presenting a poster, patiently answering passers'-by questions one on one.

Nathan Pearson

@GenomeNathan

12 years

Svante Paabo presenting his own poster. What year is this?! Only at #bog12 http://t.co/SHoE3GZ9

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Nathan Pearson

@GenomeNathan

4 years

@CT_Bergstrom Call that #misherd immunity.

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Nathan Pearson

@GenomeNathan

3 years

Reported #s since SARS-CoV2 mRNA vaccines launched on 8 December 2020: Vaccine doses given: >1800000 Allergic reactions treated: 6 Deaths: 0 New COVID19 cases: >7500000 Deaths: 136219 Questions? [sources: WHO, US CDC, Worldometer, Bloomberg]

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Nathan Pearson

@GenomeNathan

6 years

After long stealth-mode, it's time... Come make your DNA -truly- useful, in life and for science -- free. #GetRooted at . #LaborOfLove

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Nathan Pearson

@GenomeNathan

7 months

@CaulfieldTim @statnews Tim, where is the actual evidence that boosting primary-vaccinated, background-healthy, omicron-recovered young men this year helps them (or even less resilient folks in their circles), versus compounding their low but real risk of myocarditis from both infection and vaccination?

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Nathan Pearson

@GenomeNathan

10 months

1/Ok, heads up y'all. RFK Jr. cites Hou et al. (/doi.org/10.1186/s12916-020-01673-z) to justify his intimating that someone, somehow, tried to engineer SARS-CoV2 to target ACE2 in Black & non-Jewish White folks, while sparing Chinese & Ashkenazi folks.

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Nathan Pearson

@GenomeNathan

2 years

Tajima's D, what -can't- you do?...

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Nathan Pearson

@GenomeNathan

4 months

@bReCaG48 Thank you for well summarizing the talk and its main findings, to reach more listeners. 🙏

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Nathan Pearson

@GenomeNathan

2 years

Hard truths, with key lessons for us scientists ourselves...and a constructive suggestion (requisite trials with interim policies) for getting public health interventions right in future.

Vinay Prasad MD MPH

@VPrasadMDMPH

2 years

Pre-covid, I was a strong supporter of Public Health having broad legal authority to take action, but PH broke the social contract PH mandated 2 year olds wear masks, but ran zero RCTs to reduce uncertainty Pushed vax passports, even after clear vax'd could transmit 🤔 🧵🧵

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Nathan Pearson

@GenomeNathan

8 months

@DrJBhattacharya @CDCDirector @MartinKulldorff It so disheartens that they keep missing the basic point: that trust anchors in honesty. Hopes for reliable future compliance with -sensible- health policy, including in yet more dire crises, must start there...

Nathan Pearson

@GenomeNathan

8 months

Seriously? [smacks forehead] To actually earn (back) trust, how about @CDCgov gather sound data (incl. running -any- intervention RCTs), interpret stringently (minding confounds), and report accurately (incl. credible intervals). This is public health, not a political campaign.

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Nathan Pearson

@GenomeNathan

4 years

Today, COVID19 took from us Naomi Siegel, for 93 years, sharp & (fist-bumpingly) fiddle-fit. Pioneering journalist, writer, painter of vivid reality & abstraction. Sharer of wit, warmth, hardwon wisdom. Friend to many, ((great)grand)parent/sibling/partner to some luckies. Hero.

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Nathan Pearson

@GenomeNathan

2 months

@DavidSaranga @tabletmag @Israel @IsraelMFA @IDF @EmmanuelNahshon @LiorHaiat 1/Such smooth rise in the cumulative tally is exactly what's expected for an indicator that lags daily work output by a small, steady-sized team identifying a backload(!) of bodies.

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Nathan Pearson

@GenomeNathan

8 years

Got #PCA data? Be like @razibkhan , and fluidly explore it w/everyone! #Pcaso

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Nathan Pearson

@GenomeNathan

2 years

@jorgemlg @FreedZach Dubois too experimented with polar plots, for the 1900 Paris exposition...

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Nathan Pearson

@GenomeNathan

11 days

@vsbuffalo Setting aside precedent of activism against lab animal experimentation, can we please ask this question about the non-hypothetical annihilation of every university in Gaza, along with many staff, students, and faculty?

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Nathan Pearson

@GenomeNathan

8 months

Today's #FDA decision (and pending #CDC advisory rubberstamp), nutshelled...

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Nathan Pearson

@GenomeNathan

7 months

@cremieuxrecueil Is this adjusted for confounders such as height and BMI?

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Nathan Pearson

@GenomeNathan

2 years

1/When presidents & media tout a #twostatesolution , we might think it obvious/just. But that idea, to permanently exile many Palestinian families so we Jews keep nominally democratic (by exclusion) majority, dates to 1937, when the US & other powers practiced, yes, #segregation .

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Nathan Pearson

@GenomeNathan

10 months

1/Ok, found paper RFKJr. likely misinterpreted (grossly) in alleging '[via] genetic differentials of different races [in] ACE2 receptor, COVID19 is targeted to attack Caucasians & Black people [while folks] most immune are Ashkenazi Jews & Chinese'. 10.1016/j.bbrep.2020.100798

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Nathan Pearson

@GenomeNathan

6 years

Ok, Tajima's D for socks in latest laundry ~= -3.74. Time to clone. #darn #singleton #excess

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Nathan Pearson

@GenomeNathan

3 years

A year ago today, my grandma touched me for the last time. Within 4 months, COVID19 took her & 10 neighbors. Journalist, artist, reader, writer, thinker, Naomi Siegel shared so much with so many. Driving with her that day, happened to record a few nuggets of wisdom. [1/n]

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Nathan Pearson

@GenomeNathan

4 months

@bReCaG48 It intrigues that all those terms from history's dustbin ('separate but equal', apartheid, etc.) began as euphemisms, meant to sound -good- to listeners. Here's to humanity learning from our history...

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Nathan Pearson

@GenomeNathan

5 years

@biolojical Need emojis for... . bacteriophage (MS2, 1976) . bacterium (human mitochondrion, 1981) . archaeon (M. jannaschi, 1996) . yeast (1997) . roundworm (1998) . mustard (thalecress, 2000) . fruitfly (2000) . pea (someday, mendelsprettypeasplease?...)

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Nathan Pearson

@GenomeNathan

2 years

Thoughts on #Denmark deciding to stop vaccinating folks under 18 against #SARSCoV2 ...

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Nathan Pearson

@GenomeNathan

3 years

Ah Boston, where genomes feel right at home...

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Nathan Pearson

@GenomeNathan

5 years

Dismay upon grief, that another terrorist invokes DNA. In screed, NZ shooter wrote: 'Wh[y] believe there are racial differences and that th[ey] matter? Research and data. Haplogroups, phenotypes and globalized testing.' Genomicists, defusing -this- arsenal of wrongness is on us.

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Nathan Pearson

@GenomeNathan

4 years

Please share/tell us of folks born 19 April 1945. Would love to meet my mom's living peers, worldwide. Writer, wonder-sparker, sometimes prairie dog-wrangler Judith Ann Siegel would be 75 today, if not for #leukemia at 34. Missing her voice, wisdom, and chicken with eggplant.

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Nathan Pearson

@GenomeNathan

4 years

@senatemajldr @manuelrivascruz @POTUS @FLOTUS Let's hope none of the families infected downstream, by their recklessness, lose someone they love. Your president fundraised face-naked, knowing Hope Hicks was sick. He cared more for $ than for American lives. But we knew that, didn't we?

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Nathan Pearson

@GenomeNathan

10 months

2/First, and most importantly, we found that if you randomly pick two babies (or same-age adults) from earth -- one from anywhere and another from anywhere -- they will strongly tend to have very similar risk of i) catching SARS-CoV2, and ii) getting badly sick from it.

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Nathan Pearson

@GenomeNathan

8 years

Per #PopSci renderings, >5 in 6 Neandertals were male? (No wonder so few have descendants.) #PopSigh #ArchaicBechdel

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Nathan Pearson

@GenomeNathan

3 months

@ZechariahSharab 'Family'? Where is the rest of this child's family? What happened to them -- and the home, apparently reduced to rubble behind the shivering child? Where is the child's school & classmates? Answers welcome, Zechariah.

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Nathan Pearson

@GenomeNathan

2 years

‘Not all [...] victims are famous, but every one of them is dear to someone.’ Before vaxes arrived, #COVID took my grandma Naomi Siegel & many neighbors. In files yesterday, found this clip of her ca. 1950, advocating #science that soon brought vaxes to save dear ones then too.

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Nathan Pearson

@GenomeNathan

7 months

For folks wondering what #genetics tells us about the history of people in #Israel / #Palestine , nearby, and beyond, a talk summarizing decades-worth of communal insights from #DNA data.

The splendid tapestry: How DNA reveals truths, ancient & lasting |...

Amid global ethnic and political strife, can DNA help settle questions of history, diversity, and rights?Can doing so challenge assumptions on how to secure ...

www.youtube.com

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Nathan Pearson

@GenomeNathan

10 months

12/Rather, it's about how folks with agendas beyond just truth (non-experts, but as shown by CDC & many others, field-experts too) can innumerately read (and write) research findings, seizing on stuff they think must fit their ideas -- and, with name/clout like his, spreading it.

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Nathan Pearson

@GenomeNathan

4 years

@baym BMI, as your areal density (kg/m^2) if steamrolled.

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Nathan Pearson

@GenomeNathan

10 months

4/That reflects our finding that common DNA spellings only very -weakly- shape risks of getting or badly ailing from COVID -- far more weakly than other basic life factors, like age, pre-exposure/infection health, etc.

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Nathan Pearson

@GenomeNathan

2 months

@DavidSaranga @tabletmag @Israel @IsraelMFA @IDF @EmmanuelNahshon @LiorHaiat 2/Despite full investigative ability (ID #s given by -Israel-, cell/social records, etc.) and incentive to do so, Israel has not disputed even one name on the 27 October list of the first >6700 reported victims. And IDF publicly affirmed they deem the counts reliable.

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Nathan Pearson

@GenomeNathan

3 years

Amazed (and so heartened) that >1000 folks(!) came to mull clinical research consenting today at #nsgc21 . Had never seen ethics draw such a big, engaged crowd. Speaks well of #geneticcounselors , science, and esp. keen-minded session-leaders @GoodGenesGC & @furiousATGC . [1/n]

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Nathan Pearson

@GenomeNathan

4 years

Last night, on a zoom shiva call, finally saw the face of the woman who cared for my grandmother in isolation for 3 months...and kept our family in video contact via her phone, so we could send love while COVID19 wore her down. For one safe moment, a superhero took off her mask.

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Nathan Pearson

@GenomeNathan

28 days

@Black_Kettle Does this survive in 'neither', 'none' (perhaps 'nary' too), and other forms?

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Nathan Pearson

@GenomeNathan

2 months

@samiii1 @hatescapitalism No, you (and others) are invoking a plot of two globally, but not locally, informative dimensions: east Asian-likeness (x) & east/south/west African-likeness (y). Both are -trace- among pop's here, but dominate this plotted view.

Nathan Pearson

@GenomeNathan

7 months

@ZechariahSharab @AkimA64326377 Nope, nice try friend. As clearly explained to (and -understood- by) you, the 2 global PCA dimensions you foist here are east Asia-like x & Africa-like y -- trace(!) components (dark blue & pink) of the talk's fuller 10-component data, -not- its 3 big Levantine mix components.

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Nathan Pearson

@GenomeNathan

10 months

5/And those at-most-weakly COVID-shaping common DNA spellings, old enough to have spread far and wide, turn up in people -planet-wide-.

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Nathan Pearson

@GenomeNathan

6 years

@superhelical Did you run this during a [ ] severe thunderstorm [ ] geomagnetic reversal [ ] orbital re-entry through the ionosphere [ ] bikram yoga session with Jackson Pollock [ ] all of the above

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Nathan Pearson

@GenomeNathan

10 months

13/And sometimes (in our world, far too often) such spread stuff turns out to have basic explanations & implications other than what they thought. RFK Jr. rightly wants us to not get fooled by bullshit from powerful others. Following that good wish means calling out his here.

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Nathan Pearson

@GenomeNathan

10 months

3/That goes for a Chinese baby and a European baby; an Ashkenazi baby and an African/Black diaspora baby; and any other randomly picked pair of babies.

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Nathan Pearson

@GenomeNathan

2 years

Damn...Chinese Wordle is tough. 0 ∞/6

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Nathan Pearson

@GenomeNathan

5 months

@ShimonLevit Perhaps because they understand, from ample human history, that lasting peace requires *justice*?

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Nathan Pearson

@GenomeNathan

3 months

@alon_mizrahi And if you had a problem with South African apartheid you just hate Dutch people but are too afraid to admit it. ;-)

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Nathan Pearson

@GenomeNathan

2 years

@morethanmySLE And Harry Truman published a medical science journal article in 1945, urging the same. But hey, let's not rush this national healthcare thing.

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Nathan Pearson

@GenomeNathan

8 years

The real heroes: Charpentier leads w/slide thanking -bacteria- for CRISPR/Cas9. #BoG16

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Nathan Pearson

@GenomeNathan

3 years

Spotting which DNA spellings sicken a kid takes good -phenotype- data. So symptom-savvy docs ( @NouraAbulHusn , @greally ...) joined us DNA wonks ( @EimearEKenny ...) & UI experts ( @ChristianStolte , @TheYiddishBird ) to make that easier. Meet #GenomeDiver :

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Nathan Pearson

@GenomeNathan

6 years

May Jim Watson live 90 more...and fully re-open his still able mind. May the field he helped revolutionize, #genomics , grow and diversify. And may he embrace that change, so more of us, of all ethnicities & genders, can sincerely cheer his 180th. #bog18 [photo by @lynnfellman ]

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Nathan Pearson

@GenomeNathan

10 years

Delighted to now join a superb @nygenome team, to help science take deeper root in a great city, via genomic insights from & for citizens!

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Nathan Pearson

@GenomeNathan

2 months

@adiwyner Hopefully Bibi can recognize a likely lagging cumulative tally, limited by investigator team work throughput, even when a stats professor missed that:

Nathan Pearson

@GenomeNathan

2 months

@DavidSaranga @tabletmag @Israel @IsraelMFA @IDF @EmmanuelNahshon @LiorHaiat 1/Such smooth rise in the cumulative tally is exactly what's expected for an indicator that lags daily work output by a small, steady-sized team identifying a backload(!) of bodies.

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Nathan Pearson

@GenomeNathan

10 months

@Shteyngart Your bar was set high...very high...years ago, dear friend. Godspeed.

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Nathan Pearson

@GenomeNathan

10 months

10/And for the record, neither the ACE2 nor TMPRSS2 genes RFK Jr. invokes (by name or as main relevant 'receptor') shows DNA spelling variation that typically lets one guess a person's ethnicity. ACE2 varies little at all among us; TMPRSS2 by -widely shared- spelling clusters.

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Nathan Pearson

@GenomeNathan

2 years

Elders need #paxlovid . But generally healthy 40yo's taking it waste care $, speed up strains resistant to a drug others need...and have no grounds to mock ivermectin-heads. Below, @NEJM data on #COVID hospitalization in elder/young adults on paxlovid/- or ivermectin/placebo.

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Nathan Pearson

@GenomeNathan

5 months

@CaulfieldTim Tim, as a Jewish scientist who has worked to debunk both entwined conspiracisms (), I find it inexcusable for Nature to publish a paper that scores as 'antisemitic' opposing earth's last 'democracy' to still bar (by exile) its native majority from voting.

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Nathan Pearson

@GenomeNathan

2 years

6/And can we understand why ever more of us #Jews , together with other allies, now see that segregating merely stokes more grief and terror -- and that lasting peace will require -justice-, starting with honoring #rightofreturn not just for us, but for Palestinian cousins too?

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Nathan Pearson

@GenomeNathan

1 year

@CovidDataReport Winter wave indeed upon us. Numbers-wise, with Walgreens reporting ~10-fold fewer tests weekly than a year ago, might a somewhat higher proportion of those now be motivated by symptoms, rather than by non-symptom-motivated institutional requirements/personal precaution?

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Nathan Pearson

@GenomeNathan

6 months

@IChotiner Setting aside irony of invoking (westward-shifting) Lakota history per se, ask Oren whether other folks may have even -stronger- such claim to the land he claims... ...and whether history recommends -sharing-, rather than another Treaty of New Echota.

Nathan Pearson

@GenomeNathan

7 months

For folks wondering what #genetics tells us about the history of people in #Israel / #Palestine , nearby, and beyond, a talk summarizing decades-worth of communal insights from #DNA data.

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Nathan Pearson

@GenomeNathan

2 years

TFW you search an online newspaper archive and find -both- your grandfathers advertising right next to each other, on the same day in 1958...eight years before their kids happened to marry each other. 'Say, why don't we collaborate?...'

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Nathan Pearson

@GenomeNathan

8 months

@AdamRutherford John Blanke and fellow musicians, Westminster Tournament scroll, 1511 CE...

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Nathan Pearson

@GenomeNathan

2 months

@DavidSaranga @tabletmag @Israel @IsraelMFA @IDF @EmmanuelNahshon @LiorHaiat 5/Were Hamas somehow picking random daily numbers within some range to announce to the world under MoH imprimatur, they could readily have kept doing so. They did not. Because, as all independent expert assessments (incl. Israel's) have affirmed, MoH staff take work seriously.

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Nathan Pearson

@GenomeNathan

10 months

7/In genetics, we know this artifact well! Even with no real difference between populations, the more individuals we -check-, the more variation we'll manage to -see- (and, sometimes, further filter by other criteria, such as rarity, best assessable in big samples too!)...

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Nathan Pearson

@GenomeNathan

1 month

1/In March, @adiwyner & @tabletmag gaslit #Gaza 's reported death toll―not by disputing any of 1000s of published victim names, or long vouching of Gaza health ministry data by IDF/NGOs, but by #s readily expected for backlog work by adult/child ID teams.

Nathan Pearson

@GenomeNathan

2 months

@DavidSaranga @tabletmag @Israel @IsraelMFA @IDF @EmmanuelNahshon @LiorHaiat 1/Such smooth rise in the cumulative tally is exactly what's expected for an indicator that lags daily work output by a small, steady-sized team identifying a backload(!) of bodies.

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Nathan Pearson

@GenomeNathan

2 months

@MarkZlochin @DavidSaranga @tabletmag @Israel @IsraelMFA @IDF @EmmanuelNahshon @LiorHaiat That's readily expected for a period before a backlog of deaths, and concomitant logistical chaos of first ground invasion (28 Oct.) overwhelm a reporting team, who then re-organize work efforts to methodically catch up, separate from overwhelmed care wards.

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Nathan Pearson

@GenomeNathan

4 months

~2 years ago, gave a talk on what #DNA reveals of #Palestinian & #Ashkenazi history, hoping it might bolster key understanding. Weirdly, >a third of appreciative views have come in the past 2 days(!). Amazing, the power of folks caring & sharing. …

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Nathan Pearson

@GenomeNathan

10 months

6/The most infection-associated (but still just weakly) cluster of spellings, for example, on a snippet of our 3rd longest chromosome, turns up in people worldwide -- and, incidentally, most often (but still just modestly commonly!) among south Asians, -not- Black or White folks.

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Nathan Pearson

@GenomeNathan

2 years

@shim_marom Please forgive my late reply (just saw this). The talk notes that Israel, despite the sincere good aims of many who helped found & sustain it, remains a last bastion of segregationist thinking that we've come to recognize as unjust & unsustainable in many other places.

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Nathan Pearson

@GenomeNathan

2 years

@asegovia9 @Free2smile1 @Carl0s_Vela @EyalDavid1 @KesBilly @anzarmlateef @IMDibe @gomiriam63 @ToniJarvis19 @MiriamL99472550 @DavidPick33 @Buckeye_ricky @WeinsteinDr @JonathanWeissb3 @LavBaalDevarim @ihaveadreamanna @JustynMatlock @adam93452 @cool_grandad @robinsonmsr10 @whywouldyou_uk @s17766566 @Tiredoftrollsuf @MayaMurful @leftofcool13 @Wildflower1948 @Roza_Shamina @IsGrandDaughter @GiollaLachta @uflo5 @TomHaverford00 @6TK9Cn1RB4A49B1 @OlivesStones @sadcjp @fr33palest1ne @MehrMiriam @JimmyPecan @akodensybane @laltp @peteridis @saoi___ @LookForPeace2 @garybkatz @ThrstyNoneGiven @OutriderTed @IreneMinkema @daggerhaft @tharwat_yahia @YR72390 @OliverKBrown Here's 1931 mandatory census data: a big, settled local populace (incidentally, fairly fast growing by fertility), welcoming newcomers, but nowhere near matched in numbers. The DNA data affirm this, suggesting a big, stable local pop, not mass expansion from immigrant founders.

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Nathan Pearson

@GenomeNathan

12 years

Svante Paabo presenting his own poster. What year is this?! Only at #bog12 http://t.co/SHoE3GZ9

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Nathan Pearson

@GenomeNathan

10 months

Anyone trying would be tilting at windmills, rare or rife. And nothing (unless RFK Jr. can point to -any- evidence of such folly) suggests anyone even mulled, let alone tried.

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Nathan Pearson

@GenomeNathan

10 years

Good kind of chalk dust-up at #BoG14 . Snyder & Lander mull the promise/shortcomings of idiomes. #eastcoast #westcoast http://t.co/qvn51VHvEz

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Nathan Pearson

@GenomeNathan

10 months

4/While few folks in -any- of the studied populations carry -any- rare spelling in question (making such spellings awful proxies to target any ethnic group), RFK Jr. & pals reputedly tout Hou et al.'s spelling-tallies as hinting at some otherwise unevidenced tinkering conspiracy.

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Nathan Pearson

@GenomeNathan

2 years

@yanivbrandvain Introducing with full term + parenthesized acronym used in rest of paper can work well: helps readers and web-searchers(!), esp. for rarer (here, MCMC, DMI, and even MHC) and/or jargon-ambiguous (IBD, IBS, anything matching a gene name) acronyms.

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Nathan Pearson

@GenomeNathan

2 years

@Diplateevo Still working on it...

Nathan Pearson

@GenomeNathan

2 years

Damn...Chinese Wordle is tough. 0 ∞/6

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Nathan Pearson

@GenomeNathan

8 years

Mitowheel 2.0 rolls...and rocks: Take mtDNA for a spin; learn tons en route. Kudos G.Szurka!

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Nathan Pearson

@GenomeNathan

2 months

@DavidSaranga @tabletmag @Israel @IsraelMFA @IDF @EmmanuelNahshon @LiorHaiat 4/And note that @tabletmag 's tallies conveeeeniently end 10 November, just before Israel's ground invasion hit MoH headquarters, killing/scattering staff, destroying records & comms, to leave updates sporadic and tallies only by visually guessable sex/pre-teen features, not IDs.

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Nathan Pearson

@GenomeNathan

6 years

Must read this. Must read this. Oh, and you have an extra dot on there. Or is that pepper? Wait. Must buy pepper.

Stuart Ritchie 🇺🇦

@StuartJRitchie

6 years

Just out in Nature Genetics from our team: 116 genetic variants linked to neuroticism (N = 329,821)!

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Nathan Pearson

@GenomeNathan

10 months

13/And though governments (and we scientists) do foolish stuff, nothing suggests anyone actually familiar with how human DNA varies (as outlined above) would have any foothold on which to try to tinker with a Sarbecovirus to target many folks of some ethnicities, and not others.

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Nathan Pearson

@GenomeNathan

4 years

To stretch my genocentric worldview, delved last year into inner biodata I know less about...including basic bloodwork. One shock was April cholesterol >350. As folks set their yearly goals, figured I'd share how some simple changes (in my case, no prescriptions) helped. [1/n]

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Nathan Pearson

@GenomeNathan

10 months

12/As such, if you were somehow trying to hurt many/most/all people in one (or two) big ethnic groups, and few/no people in other ethnic groups, loosing SARS-CoV2 on them would -foreseeably- (not just evidently after the fact) be a -woefully- ineffective way to do so.

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Nathan Pearson

@GenomeNathan

10 months

7/And even having one chromosome with that most-risk-associated cluster of modestly common spellings appears unlikely to even, say, double your typically already low risk, relative to other people who don't carry it.

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Nathan Pearson

@GenomeNathan

5 years

Guy on bench today: Got a cell phone? Me: Yeah, why? He then asked me to call 911, as he felt 'very suicidal'. Did so, and sat w/him to await cops. So glad he spoke up. And, routed through 4 voices, learned Bos/Cambridge 911 could really confuse callers in yet tougher moments.

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Nathan Pearson

@GenomeNathan

8 years

Wishing my mom, Judith Siegel, had enjoyed more happy birthdays. Hoping others with #blood #cancers today will.

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Nathan Pearson

@GenomeNathan

10 months

9/But by definition, each such very rare spelling is...very rare! And, just as importantly, very few rare spellings among people's genomes appear to predispose to -any- immune vulnerability -- let alone vulnerability to SARS-CoV2 per se, and not far more familiar bugs too.

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Nathan Pearson

@GenomeNathan

10 months

8/Some people with very -rare- DNA spellings, by contrast, may face much stronger risk from SARS-CoV2, especially before -- but in some cases even after -- their first immune exposure via vaccine or survival of a previous infection...

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Nathan Pearson

@GenomeNathan

2 years

Thoughts on new Pekar et al. @ScienceMagazine paper (doi:10.1126/science.abp8337) re. first #SARSCoV2 infection(s) in people...

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Nathan Pearson

@GenomeNathan

5 months

@coldxman Coleman, in this clip Chomsky appears to describe (accurately) the first 'Barak-Clinton offer' (his words), per this map from the same reported source. Regardless, should Arafat have become Major Ridge, enshrining his people's segregated exile in the Treaty of New Echota?

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Nathan Pearson

@GenomeNathan

2 years

Folks crying 'vax raises risk' misread this table, willfully or not. With ~88.5% of eligible Danes fully vax'd (sources in thread), table shows remaining 11.5% have ~23% of #COVID19 cases. That's -2x- their share...and mostly deadly #delta . To beat #omicron & all strains, #vax .

William Makis MD

@MakisMD

2 years

Stunning numbers from Denmark: 56% double vaccinated are catching 65% of "other variants" & 79% of Omicron Most vulnerable group to Omicron BY FAR 25% boosted still catch 10% of Omicron cases, while unvaccinated catch 8.5% This is worse than vaccine failure. This is damage.

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Nathan Pearson

@GenomeNathan

2 years

@Caroline_Bartma Have long wondered how much faster biology would have progressed if those two had Twitter, rather than just the Gardener's Chronicle & Agricultural Gazette (1862)...

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Nathan Pearson

@GenomeNathan

19 days

Fancy getting refused entry at a gated checkpoint, by unaccountable authority, in the name of 'security'. O the injustice.

Oliya Scootercaster 🛴

@ScooterCasterNY

20 days

"MY card has been deactivated? Why?" - Shai Davidai, Pro-Israel professor at Columbia attempted to swipe his card to go inside the 'Liberated Zone' encampment with his supporters. Video by @yyeeaahhhboiii2 Desk @freedomnews .tv to license

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Nathan Pearson

@GenomeNathan

10 months

5/But here's the deal (with more to come): The tallies come from population samples that vary immensely in number, from a few hundred (Amish, whose Ashkenazi-like lack of found variants RFK Jr. for -some- reason doesn't even note...) to >32000 people (non-Jewish Europeans).

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Nathan Pearson

@GenomeNathan

10 months

@TLAVagabond Here's the breakdown of that error. Hint: It's mainly just the vastly differing sample sizes.

Nathan Pearson

@GenomeNathan

10 months

1/Ok, heads up y'all. RFK Jr. cites Hou et al. (/doi.org/10.1186/s12916-020-01673-z) to justify his intimating that someone, somehow, tried to engineer SARS-CoV2 to target ACE2 in Black & non-Jewish White folks, while sparing Chinese & Ashkenazi folks.

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Nathan Pearson

@GenomeNathan

2 months

@DavidSaranga @tabletmag @Israel @IsraelMFA @IDF @EmmanuelNahshon @LiorHaiat 3/In lagging counts capped to ~200 by daily investigative team worker capacity, male and female victim counts -naturally- anticorrelate, and with more days' counts near the population proportion (~half-half) than strongly skewed. You know, *exactly* as observed.

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Nathan Pearson

@GenomeNathan

10 months

2/Tho human ACE2 protein spellings do -not- significantly track with COVID risk in thorough worldwide study, the authors cherrypick 6(!) of 223(!) known nonstandard spellings, each very rare but inevitably least so in some region(s), to computer-guess(!) how they bind SARS-CoV2.

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Nathan Pearson

@GenomeNathan

10 months

9/But all that notwithstanding, few people in any of the studied populations have -any- of the rare variants Hou et al. focus on... ...and moreover, nothing in biology suggests such variants would interact with any particular virus (tweaked or not) in any consistent way(!)

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