Stoked to report in
@nature
the discovery of prokaryotic viperins, which naturally produce diverse anti-viral molecules !
After providing us with antibiotics, bacteria might become sources of novel anti-viral drugs. (1/9)
Could not resist.
Making that figure in 2019, I thought the newly uncovered diversity of antiphage systems was already incredible.
We now know it was just the tip of the iceberg. I hope our new review will help people dive into this wonderful field.
.
I m one of the lucky few.i got an ERC starting grant 😱🥳As one of my mentors told me, this means that i now get to do the science of my dream which is collaborative, creative, interdisciplinary and inclusive. And now i get to build and make live my little utopia. ARGGGG😊
🎉ERC Starting Grant competition results are out!
Over €619 million for the best ideas of young leading researchers - and the 1️⃣st set of grants awarded under 🇪🇺
@HorizonEU
.
Find out who, where and why 👉
#EUfunded
#FrontierResearch
#ERCStG
The lab is moving to the
@institutpasteur
. A bit intimidating to run a lab where so many of my favorite scientists work/ed. But I'm thrilled to become a Pasteurian to launch new crazy scientific projects with everyone there. I'll try my very best to be up to the task.
New year, new home! The MDM lab is moving to the Pasteur Institute in Paris
@institutpasteur
@GenGen_IP
. We're excited to join such an historical institution with a vibrant community of fantastic scientists.
A bit lost with all the new anti-phage systems out there? We developed DefenseFinder, a tool to detect all known anti-viral systems in bacterial genomes and conducted a large scale analysis on the anti-viral arsenal of prokaryotes. See more below ! (1/9)
Yesterday, i had the honor of becoming part of the first Scientific Council for the French President, among a group of 12 incredible scientists.
A tad far from my 🦠, but hopefully will help a bit in fostering the role of science & knowledge in our society and democracy.
Big milestone today. The first paper of the lab is out (the first for me as a senior author😱). Still feels crazy. Seemed like an appropriate time to also talk about the fantastic team we are building in Paris
@MDMlab_Paris
. Long live microbes and their viruses 🧫🦠🧬😍
Hello world, we are very happy, as the first paper of our new lab has just been published
@NatureComms
. It’s about describing the anti-viral arsenal of bacteria and a tool we developed to detect all known anti-phage systems called DefenseFinder.
What a great honor to receive a prize from the College de France, probably my favorite institution in France. Since 1530, its mission has been to teach top level science to the general public for free. I learned so much from the College since I was a teen. THANKS 😱😻🧬🦠🧫
🥇Le prix 2022 du Collège de France pour les jeunes chercheuses et les jeunes chercheurs est décerné à Aude Bernheim, chercheuse en
#microbiologie
et en
#g
énétique (
@Inserm
) =>
Bacteria and eukaryotes share immune mecanisms.
We searched for bacterial antiphage systems in eukaryotic genomes and found thousands of hits. Exploring this conservation of antiviral systems led us to novel defense mechanisms in humans.
Preprint
Thread👇
In a new preprint, we report that recently discovered anti-phages systems (Mokosh, Eleos, Lamassu…) have eukaryotic homologs.
We harnessed this conservation to discover novel defense mechanisms in humans.
@howmanyernest1
@gaofir
@EnzoZ_P
@AudeBer
😍😱🧬🧫I got an scientific award named after Rosalind Franklin. Genetics and Feminism, two of my biggest passions in life. So honored and empowered to join this list of fantastic women scientists. Thanks
@The_Gruber_Fdtn
@GeneticsGSA
!! And yayyyy science :) 😍😱🧬🧫
This is finally happening !
@SorekLab
introducing the first symposium on immune systems of bacteria 🥳🍾😱😭. So much awesome science to come and great people to meet. Excitement level ++++++
Thanks to the Fondation Jacques Monod and the
@Fondationfrance
for awarding me the Jacques Monod Prize. An honor to get a prize named after Monod. Thks to everyone who helped in my research, a collective work before everything AND to bacteria and phages for being so interesting
#PrixDeLaRechercheM
édicale | Battra-t-on les virus grâce aux bactéries ? Aude Bernheim, microbiologiste à l'
@Inserm
tente de répondre à cette question !
🦠 Découvrez la lauréate du Prix Jacques Monod ➡
What a special day. Yesterday I got to defend my "habilitation". Presented the science we do in the lab to awesome scientists, gathered current and former students, had old friends coming to visit. Feeling grateful to be surrounded by such great scientists/people. Merci!🥳🍾🧬
Such a great review. The complexity and beauty of phages diversity dissected and explained. From abundances in various environments and network phylogenies to the underlying cause of diversity, mosaicism. A must read by
@moira_dion
@smoineau
Happy month on my side, got (my first) funding(s) (
@ANR
and ATIP avenir) to explore different aspects of the wonderful world of anti phage systems with a new team in Paris 🦠🧬🍾🇫🇷. Big thanks to everyone who helped along that journey and very excited for the science to come 🤩
"The more i know, the less I understand". Thanks
@dbikard
for summarizing my current vibe on defense systems. All this mobile elements are messing with my head.🤯🤩
Ok, in 24 hours, more than 40 défense systems were revealed 🤩🤯🥳. Two different approaches, congratulations to all the authors! Amazing to see the role of mobile elements in these. Maybe as
@epcrocha
says, cells are just battlefields for MGE! So much cool biology to understand
The 2024 symposium on the immune system of bacteria is over. Thank you everyone for the great science, discussions and vibes.
See you next year in Paris on April 8th-10th 2025.
Avec
@laurenbastide
sur
@franceinter
, on a parlé impact du feminisme sur les sciences, CRISPR,
@vincentflora
,
@criparis
, interdisciplinarité, syndrome de l'imposteur..! Tlt incroyable d'être interviewée par une journaliste qu'on admire sur sa radio préférée. Je ne m'en remets pas
ON AIR - Pour
#LesSavantes
@laurenbastide
a rencontré
@AudeBer
spécialiste en microbiologie et en génétique, pour une interview entre intelligence artificielle et sciences accessibles à toutes et tous
Ce matin j'étais dans la matinale de
@franceinter
pour parler sciences et féminisme avec
@AliBaddou
,
@MarionLHour
et A. Palt
Plus de diversité pour une meilleure science au service de toutes et tous ! ✊🦠🧬👩🔬👩🚀👩💻
Since noticing similarities between eukaryotic and prokaryotic immune systems, we have been wondering, how do these conserved systems evolve ?
We used my favorite antiphage system, viperins, to provide some answers!
🧵 below.👏
@HelenaShomar
@HGeorjon
Happy to share our new preprint!
We used viperins🐍, to understand the conservation and diversification of immune genes across domains of life.
A deep dive in the evolutionary history of immune genes shared by prokaryotes and eukaryotes!
To promote a diverse pool of speakers/reviewers (etc), we introduced at SISB2024 a list of PIs in bacterial immunity searchable by career stage, country and gender.
Inspired by
@GaetanBurgio
. Mail me to add your name or correct mistakes!
There is nothing like a
@SorekLab
lab talk to end a conference. Sorek groupie one day, Sorek groupie always. Inspiring words from Rotem to close this first symposium. Luckily, we have next year symposium to look for with Phil Kranzusch in Boston!
Hi twitter, I'll give a
@MicroSeminar
on July 24th (8am Pacific time, 5pm Paris time, 6pm israeli time) on my post-doc work at the
@SorekLab
"Conceptual and mechanistic conservation of anti-viral immunity in Prokaryotes and Eukaryotes". YAY! Youtube link to come, open to all :)
Now in
@CellCellPress
How we solved the mystery of some of the coolest bacterial elements.
Retrons function as anti-phage defense systems! Such an exciting project and collaboration in
@SorekLab
with
@AdiMillman
and
@AAvihail
. Thread was done below when preprint was out!
Now in Cell: Bacterial retrons function in anti-phage defense !
Excited to solve a decades-old mystery on the function of these RNA/DNA hybrid molecules
Congrats
@AdiMillman
@AudeBer
@AAvihail
!
The field is going so fast, we are doing our best to keep up :). DefenseFinder now includes wonderful new systems including but not limited to: ; ; ; and a bunch of old ones ^^.
New release alert: DefenseFinder v1.2.0 is out.
When published in May, DefenseFinder included 60 systems, v1.2 now includes 130 systems. Available online and as command line (--update). Thks for all the people who reported bugs and new systems !
Thank you for staying until the end. I love to share this story so get in touch if you have questions and/or would like me to give seminars. Else, I have an online talk available on youtube :) .
Hope to see you soon for more science !
Hier, j'ai eu l'honneur de recevoir le Prix du Collège de France pour les jeunes .s.
Ce prix, c'est l'occasion pour moi de donner une conférence au collège de France🤯
Rdv le 13 décembre à 16h pour "Immunité bactérienne : à la découverte d'un nouveau monde"
#Science
#Biologie
📌 Aude Bernheim est chercheuse en
#microbiologie
🏅 Elle est lauréate du Prix du Collège de France pour les jeunes chercheuses et les jeunes chercheurs 2022
⏰ Conférence le Mardi 13 décembre 2022 à 16h
👉
This was a journey which started by the simple question: how much do we understand phage-bacteria interactions from their genomes only?
Answer: more than I thought.
Very interdiscplinary work led by an amazing trio: B. Gaborieau,
@hugovaysset
, F. Tesson.
💻🧫New preprint: How accurately can we predict diverse phage bacteria-interactions from their genomes only ?
We created a matrix of >38k phage-bacteria interactions to find out (=> AUROC 86%) & used our predictions to recommend tailored phage cocktails.
Our citizen science project
@ScienceALaPelle
spearheaded by
@VincentLibis
featured in French national newspaper. Pics by Yeganeh Foroughi, a student in the lab. Now lets get some soil and find new molecules!
I am thrilled to announce that I will soon open my independent group at
@CIRI_Lyon
🤩
My team will develop new approaches to explore the molecular arms race between phages and bacteria 🦠🧐
Join us in this new adventure in the beautiful city of Lyon !
Starting a US trip with a first time visit to Cold Spring Harbor for CRISPR CHSL. Such a beautiful mythical place for biology. Paid an hommage to Delbruck and McClintock. Loving the outdoor art. Learning a lot (too much?😅) about genome editing. Thx for the welcoming crowd!
Being a Parisian scientist has it perks. Picnic to celebrate spring and awesome scientific results but also to sample some soil. The scenery is beautiful and our bubbly wines, baguettes and cheese, well, there is a reason some clichés exist.🍷🍾🥖🧀
Want to attend the first conference on immune systems of bacteria ?
Given the speed of discovery in the field, this conference will for sure be full of crazy cool new insights. The speakers list 🤯🤩😯!
Don't wait to sign up, I believe it will be quickly full.
The first symposium on the "beyond CRISPR" immune system of bacteria: Registration open!
Feb 28th-Mar 2nd at the Weizmann Institute, Israel
A fantastic line up of speakers + talks selected from abstracts. We have limited space, hurry up and register!
Bye bye the US 🇺🇲. My brain is on fire from so many incredible discussions. Was especially impressed by the brightness of all the students i met from many labs
@HarvardMicro
@baym
@shsternberg
@doudna_lab
#Koonin
. And the fun 🤩Thank you all for the energy to do better science.
Hopefully this will be useful for both defense systems aficionados and newcomers in the field.
Idea came thx to feedback from the community & new students/experimentalists from our lab.
For me, a new way to procrastinate, get lost and wander at the diversity of defense systems!
👋DefenseFinder news !
Thinking of how we can better help the community, we provide a new website that includes a wiki on defense systems, a structure database and precomputed DefenseFinder results on >22k genomes.
Preprint:
If you want to start the week well, read this 🙂. Pascale Cossart
@cossart25001997
wrote about her scientific career and it's just fascinating to follow all the great discoveries across times and technologies.
Alphafold results look amazing! Been following deep mind work for years. So excited to try it somehow. This will empower molecular biologists so much, to make better hypothesis thanks to genomics data combined with this. What a cool time to be a scientist.
We read the great paper of
@pmaguin
,
@MarraffiniLab
and colleagues () and wrote a few words about it.
CRISPR-Cas and restriction–modification team up to achieve long-term immunity
I am in Cambridge for the first time of my life. I am quite impressed to be in a city where so many great minds did such wonderful scholar works. I died a bit when entering the real bookshop of the Cambridge University Press. So much knowledge in one place.😍🤓📚
Incredible work to understand the function of all proteins. Gives a great idea of what is known, unknown. It also beautifully shows how strucutres can reveal conservations across domains of life. Thanks to the authors for providing all these tools and datasets to explore this.
We clustered the
#AlphaFold
structure database with our novel Foldseek algorithm. We identified 2.27M clusters and analyzed them by function, annotation, domains and evolution. Amazing collaboration with
@pedrobeltrao
lab. 1/n
📄
💾
Why CRISPR-Cas are not encoded by all bacteria ? New hypothesis in our paper with
@dbikard
and Eduardo Rocha : it's a matter of (genetic) background.
#PhDpaper
My talk will be tomorrow🥳 4pm Paris time, 5pm Israel Time, 10am US Eastern Time "Conceptual and mechanistic conservation of anti-viral immunity in Prokaryotes and Eukaryotes." Live stream link: . Also possible to catch it another time, will remain there.
Tomorrow, 10am US Eastern,
@AudeBer
#uSeminar
"Conceptual and mechanistic conservation of anti-viral immunity in Prokaryotes and Eukaryotes." Live stream link:
So happy to share the product of the most fun collaboration with
@AdiMillman
and
@AAvihail
. At the
@SorekLab
we discovered Retrons function as anti-phage systems. See below for preprint and thread!
Happy to share our new preprint about how we solved the mystery of some of the coolest bacterial elements:
Retrons function as anti-phage defense systems!
See thread below by the 3 of us:
@AdiMillman
@AudeBer
@AAvihail
New paper from
@dbikard
lab is out ! Genome-wide CRISPR-dCas9 screens in E. coli identify essential genes and phage host factors. Cool read for everyone interested in CRISPR tools to study bacteria and phages. Congrats Francois,
@omnicui
, Elise and co
Congratulations
@FrancoisRousset
from
@SorekLab
@WeizmannScience
on being awarded a Bettencourt Schueller prize for young investigator . 🤩😱🏆🏆🏆🏆
@Fondation_BS
. So well deserved for all the great work on phages and bacteria. Looking forward for what you'll do next!
"If one CRISPR-Cas is great, why have two ? Or more? Or combinations of them? " Perfect summary by
@epcrocha
. Last piece of my Phd explores atypical CRISPR-Cas and their epistatic interactions.
@dbikard
Do these pVips (prokaryotic viperins) have the same function as the human viperin ?
We took ~60 pVips from diverse prokaryotes, cloned them in E. coli and challenged them with phages. Bingo, half of them provided anti-viral activity ! (3/9)
👋 everyone, we recently submitted our webservice in a dedicated journal. editors didnt send it for review bc "it's preliminary and does not work".
1) if things arent working,pls let us know?
2) if you use it, please tell us in short answer /via mail, thx!
Yesterday, we had a Pasteur mini symposium on evolution and biodiversity. So many fantastic talks: from the shape of brains to emergence of multicellularity, the infinite space of MGE or gene loss as an adaptive strategy. A large audience for a great topic. Thx +++ to organizers.
It's heatwarming to see scientists you admire getting recognition for their work. Eduardo has such a great impact on how to think about evolution and genomics, not only because of his bold and original ideas but through all the people he mentors to think about these topics.
Thrilled & honoured to receive the CNRS silver medal. Many thanks to all fantastic collaborators I had all these years, to
@CNRSbiologie
@institutpasteur
& esp. to section 21 for proposing me now and for daring to tenure me barely a few weeks after finishing my PhD back then.
So happy about
#CRISPR2021
but was so much looking forward to show all CRISPR people the best wine places in Paris. Well, people, come another time! I'll be super glad to discuss bacteria and phages while wandering in beautiful Paris, anytime 🍷🥖🥐🍾
SnapShot: Bacterial Immunity
@Nitzan_T
masterfully organized current knowledge on bacterial immune systems into a single page graphics
Out today
@CellCellPress
:
La conférence que j'ai donnée au
@cdf1530
est maintenant en ligne: "Immunité bactérienne : à la découverte d'un nouveau monde".
J'ai essayé d'y retracer pour un public non spécialiste l'histoire de ce champs de recherche et où je pense qu'il se dirige !
⏰ Mardi 13 décembre 2022, à 16h.
🔬 "Immunité bactérienne : à la découverte d'un nouveau monde"
📌 Conférence d'Aude Bernheim (
@AudeBer
), chercheuse en
#microbiologie
à l'
@Inserm
, Prix du Collège de France 2022.
👉
There is nothing quite like talks from the
@SorekLab
at CRISPR conferences. It's like really good cheese. This years flavor, the one and only
@gaofir
with beautiful work on thoeris and amazing work presented by Rotem from
@Nitzan_T
on defense via nucleotide depletion !
The places science takes us to... Discovering the wonderful
@banffcentre
, nature, art and for me science in breathtaking landscapes. Fantastic conditions to discuss "The Mathematics of Microbial Evolution".
The amount of biology in this study is just mindblowing. When i saw the last figure, i was just speechless. It's really rare to use molecular genetics to answer scientific questions in such a general way (usually use genomics for that). Big big congrats 👏
I am beyond excited to share with you the study I have been working on
@SorekLab
for the last few years 🥂
🎺Discovery of phage determinants that confer sensitivity to bacterial immune systems🎺
Posted now on bioRxiv. See 🧵below
@Soreklab
, our story with viperins started reading that paper and thinking « how cool would it be if such things existed in bacteria ».
So we looked in 40 000 bacterial genomes , and to our big surprise we did find bacterial homologs of the human viperin. We named them pVips.
What a great introduction to the phage field by
@smoineau
@VoM_2022
. I love how diverse the projects are: from fundamental biology to outreach and applying scientific findings to key society issue like antibiotics in poultry. A true inspiration for all of us phage biologsts ❤️🙏
Viperin is an important immune protein in animals. In humans, it has broad antiviral activity against DNA and RNA viruses.
In 2018, this great paper showed that viperin inhibits the replication of viruses by producing ddhCTP, an RNA chain terminator.
Several compounds discovered in this study are currently being tested on human viruses !
Our results show that anti-phage systems could be the source of novel anti-viral molecules. Maybe pVips are one of many systems which produce anti-viral molecules. Let’s catch some more.
Great thread about Daisy Roulland-Dussoix and discovery of restriction enzymes. I always mention her alongside the nobel laureates for this discovery in my lectures. So cool to have fantastic women scientist in the beginning of the history of anti phage systems!
Do you know Daisy Roulland-Dussoix? She is one of the discoverers of restriction enzymes, who’s findings paved the way for the development of recombinant DNA and cloning technologies. Accordingly, the finding was rewarded with a
#NobelPrize
. But the prize didn’t go to her... 🧵👇
We got invited to participate to a cool meeting last fall on "Understanding and predicting Microbial evolutionary dynamics" by the Microbiology Society. Here's our contribution taking a deep look at Actinobacterial anti-viral arsenals :). All the code used is online. 👏
@HGeorjon
We are excited to share our latest preprint on the genomic characterization of the anti-phage arsenal of Actinobacteria, where we reveal unique characteristics of this overlooked phylum (for instance, the absence of 1/3 of known defense systems 🤯) (1/9)
Twice in one week (and a first for me), I gave talks in human immunology meetings. Was quite intimidating to be so far away from my beloved bacteria, but I learned tons 😀. Humbling, instructive, and fun to be lost. Thanks
@v_hornung
for the challenge!
A French gaming community just raised 3.5 millions euros over one week end for the Pasteur Institute. World record for such type of initiative. WOW. Such type of solidarity is just incredible.
55 gameurs français viennent de lever le temps d’un week-end plus de 3 millions d’euros au profit de l’institut Pasteur.
Vous êtes inspirants et vous nous démontrez que tout est possible pour soutenir une cause pour laquelle on croit. Bravo
#ZEvent2019
!
Unearthing Ancient Origins of Antiviral Immunity: Can microbes provide clues about origin of
#pathogen
defenses?
@bioBarber
&Baker discuss
@SorekLab
findings that mammalian
#antiviral
protein viperin is more ancient & conserved than previously appreciated
After a fascinating first edition in Israel in 2023, the symposium on the immune systems of bacteria is back. April 16-18 2024 in Boston. Save the date!
I can't wait for the 2024 symposium on the "beyond CRISPR" immune system of bacteria, which will take place in Boston on April 16-18, 2024. Save the date!
Beautiful week for anti-phage defense displaying similarities with eukaryotic enzymes with two wonderful preprints with awesome structures.
SPARTA / Agos by
@DCSwarts
@MartinJinek
labs
Ubiquitination pathway by
@_KevinCorbett
lab
Anyone into bacterial genetics?
This work pinpoints the role of RNA-guided nucleases in "biasing the selfish inheritance of transposable elements".
Molecular mechanism for selfishness? Yes, and done so with cool bioinformatics, RNA seq on an exotic bacteria and lacZ assays...!
Thrilled to see our latest work published this week, on the essential roles of IscB/TnpB -- ancestral homologs of Cas9/Cas12 -- in transposon maintenance & spread. A wonderful team effort led by the talented Chance Meers! Thread on bioRxiv version below...
With both wonderful talks from
@dbikard
and
@PeterFineran
, clear that complex multiple lines of defense are common in bacteria and constitutes a fantastic avenue to study. On average, bacteria have 7 antiphage syst. Imagine all the crazy molecular mechanisms out there❤️.
#VoM2022
Bacterial origins of human innate immune mechanisms
Tanita Wein skillfully summarized current knowledge on how key components our own immune system evolved from bacterial anti-phage defenses
Out today in Nature Reviews Immunology
Welcome to CBASS : a new widespread defense system agaunst phages based on cGAMP signalling discovered by
@SorekLab
. One prokaryote ancestor of human immune system!
On the origin of immunity
Remarkable similarities between human and bacterial immune systems.
Cyclic GMP–AMP signalling protects bacteria against viral infection
Congrats CBASS team! Daniel Cohen
@AdiMillman
@GilAmitai
@shany_doron
#cGAS
-
#STING
It's out!!!! This is an instant classic that everyone interested in phage bacteria interactions (or generally Microbiology) should read. Congrats again :) .
I am excited to share with you the final version of my work
@SorekLab
studying
💠How bacterial immune systems sense phage infection💠
Published now in
@CellCellPress
🍻
See thread below for a recap and highlights added during the review process ⬇️
1/11
Turns out, viperins have friends! This wonderful paper describes the discovery of novel anti-viral enzymes playing with nucleotides that are shared by bacteria and eukaryotes. A completely novel mechanism of anti-viral defense in bacteria. Congrats
@Nitzan_T
et al.
I'm excited to share my new preprint on how bacteria use ✨nucleotide depletion✨ as an amazing new anti-phage defense mechanism conserved between prokaryotes and eukaryotes!
Graphical abstract and thread below! >>>
Super cool findings on minimalist phage satellites. Minimal and still encode defense systems!!
Both satellites and defense systems worlds are expanding ++.
So much to discover by exploring natural populations.
A huge thanks to all the people who helped this fantastic scientific adventure and in particular R. Sorek for the guidance, freedom, creativity
@AdiMillman
the magician bioinformatician
@gaofir
and
@GilAmitai
for the crazy brainstorms and
@HelenaShomar
for the bioenginnering.
Fantastic findings ! Absolutely convinced that studying immune systems through domains will allow to illuminate the molecular complexity of antiphage system in a much faster way thanks to their modularity. Very powerful to understand anti viral immunity across domains of life.
I’m very excited to share the first results of my postdoc
@SorekLab
🥳🤩🚨
We report a new family of immune effectors that is conserved across the tree of life.
👋🚨 Only a few days AND a few spots left to register to the 2024 symposium on the immune system of bacteria.
If you have not registered yet, now is the time!
Wonderful project that led to so many discoveries, scientific discussions and adventures. It was eye opening for me, how to explore such a vast space uncovered by
@AdiMillman
analysis. Learned so much from
@SorekLab
on how to navigate the unknown. Science fun +++ 🤩🧫🧬
OK. I’ve been waiting for this moment for a while… 🤗🫣🥳
Excited to share our new preprint where we discover 21 new anti-phage systems:
"An expanding arsenal of immune systems that protect bacteria from phages"
@SorekLab
1/7
I'm not a biochemist, but the first session of
#ISB2023
just BLEW my mind. Crazy structures, crazy cool mechanisms and such beautiful slides. Congrats to all speakers
Using a phylogenetic analysis, we show the eukaryotic viperin has originated from a clade of prokaryotic viperins.
So we tried and cloned the human viperin in E. coli, the human gene protected against bacterial viruses ! (4/9)
New version of CRISPRFinder. CRISPRCasFinder, an update of CRISRFinder, includes a portable version, enhanced performance and integrates search for Cas proteins. Paper here . Website there .
So i have a doppelganger in the world. My (twin) sister
@SegoleneBer
just joined Twitter! She's a cardiopediatrician, currently taking some time to follow another passion: doing a PhD in embryology
@InstitutImagine
@institutpasteur
! Clearly a badass
#WomenInSTEM
to follow :).
Finally, we developed a genetic reporting system and showed that pVips protect against T7 phage infection by inhibiting viral polymerase-dependent transcription, implying an anti-viral mechanism of action similar to the animal viperin. (7/9)
Last piece of my PhD on bioRxiv :) : about CRISPR-Cas that are not one CRISPR, one Cas. We found preferential associations between subtypes, complex loci with several interference modules but only one adaptation one. Also cool stuff on CRISPR on MGE.
Many bacterial & archaeal defense systems are encoded by mobile genetic elements.
@eprocha
&
@dbikard
argue that this challenges our ideas of their role in cells: Who's defending? From what? And what's the role of the cellular genome in this?
#PLOSBiology
Happy to had the chance to contribute to this awesome discovery of
@FrancoisRousset
@dbikard
with
@epcrocha
Prophages encode hotspots of diversity full of antiphage systems.
Paves the way for a new method to uncover novel antiphage systems and opens many evolutionnary questions.
I am very excited to share our new preprint! 🤩
We report the presence of reservoirs of anti-phage
systems in genomic hotspots encoded on prophages!
The story behind this incidental discovery 👇
Wonderful study. I love how studying some specific weird bacteria that someone sequenced for completely different purposes ends up providing the operons that generate such a cool discovery. ❤ microbial genomics. Also awesome (and surprising?)that they work against coliphages! 👏
I am beyond excited to share our new preprint!🤩
We find that CARD domains are an ancient component of innate immune systems conserved from bacteria to human, and that they are essential for gasdermin-mediated defense in bacteria!
@SorekLab
Kranzusch lab
Our results suggest that pVips produce new types of anti-viral molecules which, to the best of our knowledge, were not observed before in nature.
@HelenaShomar
, N. Tal and M. Rosenberg from Pantheon Biosc. purified some pVips and confirmed these results in vitro. (6/9)
A beautiful new anti-phage mechanism uncovered thanks to elegant experimental set ups. Exciting to wonder if eukaryotic homologs function the same way.
Proud to share our latest discovery: Bacteria conjugate ubiquitin-like proteins to interfere with phage assembly
A new concept in antiphage immunity, and a mechanism for ISG15-like antiviral defnese in bacteria. Big congrats to talented
@Jens_Hoer
!
A 🧵