Cell Host & Microbe @cellhostmicrobe Twitter profile

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Cell Host & Microbe

@cellhostmicrobe

2 years

Rethinking healthy eating in light of gut microbiome: This review examines how diet- #microbiome -host interactions can validate, refine & innovate #dietary guidelines. Integration of microbiome science into #nutrition research will improve healthy eating

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Cell Host & Microbe

@cellhostmicrobe

1 year

Gut microbiome lipid metabolism and its impact on host physiology. Featured Review from @ericmichbrown Clardy @HMS_BCMP @TheXavierLab examining # lipids that #microbiome species can synthesize and their function on host physiology

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Cell Host & Microbe

@cellhostmicrobe

4 years

Infection and Rapid Transmission of SARS-CoV-2 in Ferrets: New work shows that ferrets are highly susceptible to #SARSCoV2 infection and effectively transmit the #virus by direct or indirect contact, recapitulating human #infection and transmission

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Cell Host & Microbe

@cellhostmicrobe

4 years

Type I & III Interferons –Induction, Signaling, Evasion, &Application to Combat COVID-19: Park& @VirusesImmunity review protective vs.pathogenic roles IFNs in #coronavirus infections & discuss prophylactic/therapeutic potential of #interferons for #COVID19

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Cell Host & Microbe

@cellhostmicrobe

1 month

Opposing diet, #microbiome & metabolite mechanisms in IBD. Combo of genetics, reduced dietary fiber &mucin-degrading bacteria triggers IBD. Mucus loss promotes Th1 that drives #colitis . Fiber-free exclusive enteral nutrition prevents colitis @EricCMartens1

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Cell Host & Microbe

@cellhostmicrobe

2 years

Dietary changes leave genetic signature in #microbiota : Bacteroides thetatiotaomicron evolves under nutritional changes. #Diet changes increase intraspecies diversity & mutations w/Western-style diet favor host mucus consumption @DapaTanja @KarinaXavierLab

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Cell Host & Microbe

@cellhostmicrobe

4 years

An infectious cDNA clone of SARS-CoV-2: @TheMenacheryLab Shi lab @utmbhealth &Co generated an infectious cDNA clone of #SARSCoV2 & mNeonGreen reporter virus. Recombinant SARS-CoV-2 and reporter virus replicate as efficiently as original clinical isolate

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Cell Host & Microbe

@cellhostmicrobe

2 years

Innate Immune Responses to Human Gut #Microbiota from Phylum to Strain: @MatthewSpindl13 @jeremiahfaith1 examine how innate immune system responds to 277 human gut commensal #bacterial strains. Taxa induce signatures w/predictable immune phenotypes in mice

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Cell Host & Microbe

@cellhostmicrobe

2 years

#Microbiota modulation of intestinal epithelial homeostasis. @theGarrettLab show F. rodentium promotes epithelial proliferation & turnover by dampening retinoic acid production that supports survival of eosinophils, which suppress pro-proliferative IFNγ

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Cell Host & Microbe

@cellhostmicrobe

1 year

Horizontal gene transfer among host-associated microbes. @doctor_jams @MartaLourenco21 @gordoisabel1 review studies on mechanisms of horizontal gene transfer & complex interactions that these may entail in driving eco-evolutionary dynamics of #microbiomes

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Cell Host & Microbe

@cellhostmicrobe

7 months

New work on early-life microbiota & obesity. @catie_shelton @Mari_Byndloss show early #antibiotics exacerbate diet-induced #obesity by disrupting #microbiota -epithelium interactions. Lactobacillus metabolite-phenyllactic acid-regulates PPARγ to limit fat

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Cell Host & Microbe

@cellhostmicrobe

10 months

Vaginal microbiota transfer to cesarean-born infants. In a triple-blind randomized controlled trial, new work shows that VMT is likely safe and may partially normalize neurodevelopment and the fecal #microbiome in #cesarean -born infants

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Cell Host & Microbe

@cellhostmicrobe

2 years

Bacteriostatic antibiotics promote CRISPR-Cas immunity: @TatianaDimitriu @edzewestra find bacteriostatic #antibiotics promote #CRISPR -Cas immunity by slowing #phage replication. Delayed phage production allows cells to acquire spacers against phages

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Cell Host & Microbe

@cellhostmicrobe

2 years

How gut microbiota helps keep us vitaminized. @Zimmermann_Lab highlights work of @BonakdarMaryam @LindsayCzuba @ShipraVaishnava examining metabolic host-microbiota interactions & linking diet, #microbiota & host functions in context of vitamin A metabolism

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Cell Host & Microbe

@cellhostmicrobe

5 months

Fiber-deficient diets reprogram the #microbiota . Fitzgerald & Sorbara @uofg discuss findings that fiber-deficient diet thins mucus layer & alters microbial cross-feeding, causing pro-inflammatory Mucispirillum to move from epithelium to ameliorate #colitis

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Cell Host & Microbe

@cellhostmicrobe

2 years

In honor of our 15 years, we bring you an Anniversary Special Review issue on Maternal-Infant Health. As we “come of age” to our teens, we take a look back at the importance of early-life.

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Cell Host & Microbe

@cellhostmicrobe

2 years

“Dirty mice” as preclinical vaccine testing model: @JessicaFiegePhD @Katharine_Block @Masopust_Vezys @LangloisLab show natural microbial exposure of mice induces post-vaccination signatures that are more similar to humans

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Cell Host & Microbe

@cellhostmicrobe

6 years

The power of fiber: Bäckhed & Co’s review examines the impact of dietary #fiber on #gut #microbiota in host health and disease @cellhostmicrobe

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Cell Host & Microbe

@cellhostmicrobe

1 year

Microbial seeding in early life. @DrSuchiHourigan &Dominguez-Bello highlight @DebbyBogaert work unraveling mother-infant microbial seeding by examining multiple maternal-infant niches. “Auxiliary” pathways may compensate when seeding patterns are perturbed

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Cell Host & Microbe

@cellhostmicrobe

3 years

Cytosolic replication in epithelial cells fuels #Salmonella : Using genetic engineering to deplete cytosolic bacteria from enterocytes, new work shows intracytosolic replication feeds expansion of intestinal #STyphimurium needed for efficient shedding

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Cell Host & Microbe

@cellhostmicrobe

6 years

The power of propionate: Gut commensal Bacteroides production of the metabolite, propionate, mediates colonization resistance to #Salmonella #infection . New from @monack_lab @cellhostmicrobe

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Cell Host & Microbe

@cellhostmicrobe

4 years

Enteric Pathogen Beats the Competition: To subvert colonization resistance & #microbiota -mediated depletion of gut amino acids, #Citrobacter rodentium induces amino acid biosynthesis. High protein diet increases amino acids &promotes #pathogen colonization

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Cell Host & Microbe

@cellhostmicrobe

4 years

Dynamic immune response shapes #COVID19 progression: Daily transcriptomics of whole blood from #SARSCoV2 patients reveals early #immune response is highly dynamic. Aside from IL-1, peak cytokine expression occurs after lowest point in respiratory function

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Cell Host & Microbe

@cellhostmicrobe

4 years

ROS gives E. coli a boost: @Winter_lab reveals that reactive oxygen species (ROS) produced by intestinal epithelium promote outgrowth of #Ecoli . Detoxification of inflammatory ROS through AppBCX allows E. coli to respire in otherwise anaerobic environment

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Cell Host & Microbe

@cellhostmicrobe

4 years

Pseudomonas aeruginosa vs. Burkholderia cepacia complex species in #cysticfibrosis : @TheRurrJurr @peggy_cotter show that Bcc pathogens, using T6SS, outcompete host-adapted #Paeruginosa isolates, which lose #T6SS during evolution w/in CF respiratory tract

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Cell Host & Microbe

@cellhostmicrobe

1 year

Our March issue is now live – with insights on mucus factories, fungal escape routes, superspreaders, and more

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Cell Host & Microbe

@cellhostmicrobe

5 months

Infant gut phageome. @ClareLou9 @BanfieldLab characterize preterm & full-term infant gut phageome succession during first 3 yrs. 9% of #phage strains establish long-term residency. Stop codon reassignment&tail fiber mutations may aid viral gut colonization

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Cell Host & Microbe

@cellhostmicrobe

4 years

Spatial Heterogeneity of Gut Fosters #Bacteria -Phage Coexistence: @MartaLourenco21 @luisadesordi & Debarbieux lab show uneven spatial distribution of #bacteriophages in gut creates #bacterial refuges, which may hinder efficacy of #phagetherapy

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Cell Host & Microbe

@cellhostmicrobe

3 years

Adaptation of intestinal #microbes to immune activation: #Immune system activation rapidly alters gene transcription in intestinal symbiotic #bacteria , w/minimal effects on #microbiota composition but notably effects on metabolome & SCFA production

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Cell Host & Microbe

@cellhostmicrobe

3 years

Long-term evolution/short-term adaptation of microbiota: 6-year exp in mice stably colonized shows how strains/sub-strains evolve. #Microbiota adaptation occurs via long-term +selection of variants & short-term changes in transcriptomes&substrain frequency

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Cell Host & Microbe

@cellhostmicrobe

2 years

Gut microbiota-derived bile acids. This review examines mechanistic links between #gut #microbiota -derived #bileacids & host #immunity , intestinal inflammation & #tumorigenesis . Bile-acid-related human omics data are summarized & therapeutics are discussed

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Cell Host & Microbe

@cellhostmicrobe

6 years

Brush up on your #virology with our Featured Five reviews on #virus -host dynamics, including viral latency, #evolution , #antiviral defense, and more from @cellhostmicrobe

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Cell Host & Microbe

@cellhostmicrobe

10 months

Eating our way to gut #microbiome characterization. Highlight of @Nature paper from Huang & Relman @Stanford introducing ingestible device capable of collecting in situ samples across regions of human intestine for multi-omics analysis

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Cell Host & Microbe

@cellhostmicrobe

3 years

EECs relay signals from gut microbes: @RawlsLab @ye_lihua find that #gut #bacteria produce tryptophan catabolites that activate Trpa1 channels on enteroendocrine cells, causing rapid activation of enteric & vagal #neurons

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Cell Host & Microbe

@cellhostmicrobe

8 months

Precision modulation of dysbiotic microbiomes. Introducing human-milk-oligosaccharide-fed Bifidobacterium longum subspecies infantis into adult, #antibiotic -perturbed gut microbiomes leads to engraftment & reproducible changes in #microbiome @prolacta

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Cell Host & Microbe

@cellhostmicrobe

14 days

Opposing diet, #microbiome & metabolite mechanisms in IBD. Combo of genetics, reduced dietary fiber &mucin-degrading bacteria triggers IBD. Mucus loss promotes Th1 that drives #colitis . Fiber-free exclusive enteral nutrition prevents colitis @EricCMartens1

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41

108

Cell Host & Microbe

@cellhostmicrobe

5 years

Why does #influenza vaccination elicit poor efficacy in elderly individuals? New work reveals that elderly adults have reduced accumulation of de novo immunoglobulin gene somatic mutations & are unable to adapt #antibody responses upon #flu #vaccination

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Cell Host & Microbe

@cellhostmicrobe

5 years

Focus on #Phages . Our February Special issue exploring #bacteriophages in now live @cellhostmicrobe

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Cell Host & Microbe

@cellhostmicrobe

1 year

i-ROBOT, an intelligent probiotic. New work presents i-ROBOT, a #probiotic for diagnosis & amelioration of #InflammatoryBowelDisease . i-ROBOT noninvasively records disease information & uses self-regulated drug release responsive to inflammation in mice

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Cell Host & Microbe

@cellhostmicrobe

3 months

Gut #microbiota influences respiratory viral infection. Gut colonization by segmented filamentous bacteria reprograms lung macrophages, enhancing their ability to combat respiratory viruses ( #influenza #SARSCoV2 #RSV ) Gewirtz & Plemper labs @GeorgiaStateU

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Cell Host & Microbe

@cellhostmicrobe

4 years

IFN therapy for COVID-19: In retrospective study of #COVID19 patients, early administration of interferon-α2b was associated w/reduced mortality-but late #interferon therapy increased mortality&delayed recovery, suggesting IFN timing is crucial. #SARSCoV2

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Cell Host & Microbe

@cellhostmicrobe

3 months

#Microbiota -bile acid axis repairs aspirin-mediated damage. P. goldsteinii &metabolite 7-keto-lithocholic acid promote repair of aspirin-associated intestinal damage by suppressing bile acid receptor FXR & maintaining Wnt signaling in intestinal stem cells

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Cell Host & Microbe

@cellhostmicrobe

4 years

Phage-Bacteria Associations: Analyze. Match. Develop Therapies: @Naama_GZ & Co examine recent works that combined metagenomic analysis & experiments to study #phage - #bacteria associations in order to develop future research tools and therapies

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Cell Host & Microbe

@cellhostmicrobe

4 years

Impact of natural microbes on immune system maturation: @CadwellLab @LokePng &Graham lab release mice into a wild enclosure & find that increases in circulating granulocytes are associated w/ altered #microbiota , notably expansion of #fungi .

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Cell Host & Microbe

@cellhostmicrobe

3 years

Unearthing Ancient Origins of Antiviral Immunity: Can microbes provide clues about origin of #pathogen defenses? @bioBarber &Baker discuss @SorekLab findings that mammalian #antiviral protein viperin is more ancient & conserved than previously appreciated

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Cell Host & Microbe

@cellhostmicrobe

5 years

On this Valentine's Day, we are sending lots of love to #bacteriophages . Our February issue is a Special issue devoted to #phages @cellhostmicrobe

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Cell Host & Microbe

@cellhostmicrobe

4 years

Snatching the Crown from SARS-CoV-2: @Virusnerdette examines works describing pseudotyping of VSV w/ #SARSCoV2 spike, which allows virus neutralization assays at BSL-2 and is a candidate vectored #vaccine to elicit protective immunity against SARS-CoV-2

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Cell Host & Microbe

@cellhostmicrobe

5 months

Fiber-free diet inhibits colitis. In #Crohns disease-like #colitis model, fiber exclusion reduces Mucispirillum, a mucus-dwelling pathobiont. Fiber deprivation reduces nutrients & impairs DNRA metabolic pathway in Mucispirillum to promote re-localization

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Cell Host & Microbe

@cellhostmicrobe

10 months

Intestinal mucus & their glycans: A habitat for thriving #microbiota . @AnaSofLuis & Hansson @goteborgsuni review how commensal #bacteria can be selected by & utilize complex O-glycans of colonic mucins--while being kept at distance by inner mucus layer

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Cell Host & Microbe

@cellhostmicrobe

1 year

Featured Article: Mother-to-infant microbiota transmission & infant microbiota development across body sites. Maternal contributions to infant #microbiota differ by niche, w/main role for #breastmilk microbiota. @DebbyBogaert

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Cell Host & Microbe

@cellhostmicrobe

5 years

Septins conquer the divide: @KrokowskiSina & Mostowy lab discover that host septins recognize dividing #bacterial cells for entrapment and delivery to the lysosome @cellhostmicrobe

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Cell Host & Microbe

@cellhostmicrobe

3 years

Mapping SARS-CoV-2 escape: @jbloom_lab & Crowe lab develop method to map all #SARSCoV2 RBD mutations that escape #antibody binding. Applying method to Abs yields maps predicting mutations that arise when #virus is grown w/Ab

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Cell Host & Microbe

@cellhostmicrobe

4 months

Neonatal microbial-skin crosstalk shapes allergic inflammation. Early postnatal colonization w/skin #microbiota , esp. IAld-producing #Staphylococcus , induces ILC2 priming by TSLP. This early ILC2 priming promotes allergic skin inflammation in adulthood

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Cell Host & Microbe

@cellhostmicrobe

2 years

The developing infant gut #microbiome : A strain-level view. @HagayEnav @BackhedLab @RuthLeyMicro review recent studies on #infant #gutmicrobiome , moving from broad taxonomic studies to strain level analyses & shedding new light on colonization & maturation

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Cell Host & Microbe

@cellhostmicrobe

4 years

Alveolar epithelium, a central hub in #antibacterial defense: @SunnyShinLab show that #Legionella -infected alveolar #macrophages induce alveolar epithelium to produce GM-CSF, which reprograms monocytes, amplifying inflammatory responses&promoting defense

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Cell Host & Microbe

@cellhostmicrobe

5 years

#Fungi linked to #IBD : New work shows that the common commensal skin yeast, Malassezia, is associated with #CrohnsDisease and exacerbates #Colitis in mouse models through mechanisms requiring CARD9

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Cell Host & Microbe

@cellhostmicrobe

3 years

ROS gives E. coli a boost: @Winter_lab reveals that reactive oxygen species (ROS) produced by intestinal epithelium promote outgrowth of #Ecoli . Detoxification of inflammatory ROS through AppBCX allows E. coli to respire in otherwise anaerobic environment

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Cell Host & Microbe

@cellhostmicrobe

1 year

Phage satellites ride on coat-“tails”. #Phage satellite family encodes all proteins to produce capsids-where satellite genomes are exclusively packaged-& only parasitizes phage tails to produce particles @Alqurainyn Miguel-Romero @AlfredFillol @jrpenades

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Cell Host & Microbe

@cellhostmicrobe

2 years

Bacteroides PULs determine fitness & function: @oventurelli2 & Co show Polysaccharide utilization loci (PULs) in #Bacteroides uniformis provide fitness advantage/disadvantage in gut #microbiota that depends on nutrient availability

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Cell Host & Microbe

@cellhostmicrobe

4 years

Complex Immune Dysregulation in COVID19 patients w/severe respiratory failure. Macrophage activation syndrome&defective #AntigenPresentation driven by IL-6 precede severe respiratory failure in #COVID19 . IL-6 blocker partially rescues #immune dysregulation

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Cell Host & Microbe

@cellhostmicrobe

4 years

Aspartate & Malate Drive Salmonella Colonization: #Salmonella Typhimurium imports aspartate/malate via DcuABC transporters &converts these into fumarate to fuel anaerobic H2/fumarate respiration, allowing bacteria to compete in #microbiota -colonized #gut .

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Cell Host & Microbe

@cellhostmicrobe

3 years

Infant gut resistome: Analysis of #antibiotic resistance gene (ARG) distribution in #infant gut shows E.coli is ARG reservoir. Infant gut resistome associated w/environmental factors, #gut #microbiome maturation& #bacteria associated w/ #asthma development

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Cell Host & Microbe

@cellhostmicrobe

3 years

Bacteria induce skin regeneration: New work finds that #skin #bacteria induce IL-1β signaling and activate keratinocytes via a pathway requiring IL1R/Myd88 to stimulate hair follicle regeneration and wound healing

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Cell Host & Microbe

@cellhostmicrobe

10 months

Microbiome Enterosignatures: @c_frioux @Falk_tw introduce enterosignatures as microbial guilds whose assemblies are accurate descriptors of human gut #microbiome composition. Enterosignature composition is dynamic & changes over lifetime

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Cell Host & Microbe

@cellhostmicrobe

3 years

Carbon source competition limits : #Ecoli provides colonization resistance against #Salmonella by competing for carbon source galactitol w/specific #microbiota . Lachnospiraceae consuming C5/C6 sugars also play roles @baerboletta

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Cell Host & Microbe

@cellhostmicrobe

2 years

Sensing a pattern: @kvnforsberg discusses work of @zhangf @ScienceMagazine showing pattern-recognition receptors found in eukaryotes are also in bacteria. #Bacteria use similar receptors to detect conserved #phage proteins & activate analogous immunity

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Cell Host & Microbe

@cellhostmicrobe

8 months

AMPing up inflammation. @CadwellLab shows #antimicrobial REG3 proteins overproduced in IBD perpetuate inflammation by depleting E. faecium from #microbiota . Enterococcus DL-endopeptidase SagA activates NOD2 to produce IL-1β, which induces protective IL-22

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Cell Host & Microbe

@cellhostmicrobe

4 years

IFN therapy for COVID-19: In retrospective study of #COVID19 patients, early administration of interferon-α2b was associated w/reduced mortality-but late #interferon therapy increased mortality&delayed recovery, suggesting IFN timing is crucial. #SARSCoV2

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Cell Host & Microbe

@cellhostmicrobe

2 years

Trick & no treat: Carbohydrate preemption by commensal Enterobacteriaceae. @ShealyNic @Mari_Byndloss highlight works from @baerboletta @StrowigLab showing how Enterobacteriaceae preempt #pathogen carbohydrate utilization--dependent upon #microbiota comp.

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Cell Host & Microbe

@cellhostmicrobe

4 years

Neutralizing Ab & soluble ACE2 inhibition of replication-competent VSV-SARS-CoV-2 & clinical isolate of SARS-CoV-2: @paulrothlauf @vsv512 JB Case &Diamond lab generate replication-competent VSV expressing #SARSCoV2 spike that closely parallels SARS-CoV-2

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Cell Host & Microbe

@cellhostmicrobe

13 days

Small RNAs direct attack & defense. VP882 phage activation promotes sRNA base pairing w/V.cholerae or phage transcripts via Hfq. Phage&host-encoded sRNAs regulate expression @ post-transcriptional level to enhance or inhibit phage replication @papenfortlab

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Cell Host & Microbe

@cellhostmicrobe

2 years

Bacteriostatic antibiotics promote CRISPR-Cas immunity: @TatianaDimitriu @edzewestra find bacteriostatic #antibiotics promote #CRISPR -Cas immunity by slowing #phage replication. Delayed phage production allows cells to acquire spacers against phages

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Cell Host & Microbe

@cellhostmicrobe

4 years

Virome in IBD: @adamclooney , T Sutton @colinhillucc &Co examine changes in human gut #virome by analyzing known & unknown viral sequences; they provide evidence that healthy core of virulent bacteriophage is replaced by temperate #bacteriophage in #IBD

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Cell Host & Microbe

@cellhostmicrobe

1 year

The Social Network of Microbes. Our April Special Issue is now live! Find reviews and perspectives on the communication patterns and social lives of #microbes

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Cell Host & Microbe

@cellhostmicrobe

1 year

Beneficial effects of #FecalMicrobiotaTransplantation in recurrent C.difficile. Review discussing potential mechanisms of action of FMT in preventing recurrent #Cdiff -from ecological, microbial mediated metabolic, immunological & epigenetic perspectives

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Cell Host & Microbe

@cellhostmicrobe

2 years

Debugging gut-brain axis in depression: @CassGheorghe @jfcryan & Clarke highlight new insights into #microbiome gut-brain axis. GI #testosterone degradation by #bacterial strain is uncovered as potential mechanism impacting symptoms in males w/depression

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Cell Host & Microbe

@cellhostmicrobe

9 months

Mucin-binding adhesins: A key to unlocking the door of mutualism. @Goo9Han @ShipraVaishnava highlight work of @tjarrods @GuilleminLab unveiling that mucus binding by bacteria is crucial for host-microbe symbiosis.

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Cell Host & Microbe

@cellhostmicrobe

2 years

Won’t you be my neighbor? The importance of biogeography and nutrient niches in the gut. @A2_Insanity @joeyzacks highlight work from @abaumler demonstrating how a #commensal and #pathogen differ in how and where they acquire nitrate

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Cell Host & Microbe

@cellhostmicrobe

11 months

Bacterial molecular syringe for drug delivery. Lu & Cai highlight work of @kreitz_joseph @zhangf @Nature reporting syringe-like protein delivery vector engineered from natural endosymbiotic #bacteria for potential therapeutic & human use.

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Cell Host & Microbe

@cellhostmicrobe

3 years

Coevolution between bacterial #CRISPR -Cas systems & their #bacteriophages : @drbridgetwatson @edzewestra @StinekevanHoute review when/why #CRISPRCas immunity against #phages evolves, how #viruses overcome this immunity &how such coevolution develops w/time

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Cell Host & Microbe

@cellhostmicrobe

1 year

Infection leaves a mark on #microbiome . @Goodman_lab show #gut commensals can respond to transient infection through mutation & selection. Infection-induced selective sweeps replace existing #commensal populations w/inflammation-adapted variants

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Cell Host & Microbe

@cellhostmicrobe

4 years

Replication-competent VSV for studying SARS-CoV-2 spike-mediated cell entry & its inhibition: @ChandranLab @Jangra_RohitK @EugeDieterle @HaslwanterD & Herbert generate infectious rVSV encoding #SARSCoV2 Spike suitable for screening & mechanistic studies

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Cell Host & Microbe

@cellhostmicrobe

3 years

Brain development in premature infants: A bug in the programming system? @AAatsinki @somahony1 @UCCpsychiatry highlight work from @Sekifilipdavid @WisgrillL @DavidBerry44 uncovering overgrowth of Klebsiella in #gut #microbiota of #prematureinfants

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Cell Host & Microbe

@cellhostmicrobe

1 year

Deciphering the quorum-sensing lexicon of the gut microbiota. @KarinaXavierLab @Rita_A_Oliveira review approaches to decipher chemical signals exchanged among intestinal #bacteria & unravel mechanisms driving establishment & resilience of gut #microbiota

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Cell Host & Microbe

@cellhostmicrobe

2 years

“Dirty mice” as preclinical vaccine testing model: @JessicaFiegePhD @Katharine_Block @Masopust_Vezys @LangloisLab show natural microbial exposure of mice induces post-vaccination signatures that are more similar to humans

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Cell Host & Microbe

@cellhostmicrobe

5 years

#Pseudomonas ’s magic touch: Upon host cell contact, #Paeruginosa activates a c-di-GMP-dependent surface program to promote adherence, which stimulates asymmetric division that facilitates #bacterial spread @urs_jenal @cellhostmicrobe

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Cell Host & Microbe

@cellhostmicrobe

2 years

#Microbiota modulation of intestinal epithelial homeostasis. @theGarrettLab show F. rodentium promotes epithelial proliferation & turnover by dampening retinoic acid production that supports survival of eosinophils, which suppress pro-proliferative IFNγ

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Cell Host & Microbe

@cellhostmicrobe

4 years

Prevotella takes on the competition: @EricJCGalvez &Co identify Prevotella species in mouse #gut & examine how dominant species outcompete #commensal #bacteria , including other Prevotella, via specific polysaccharide utilization loci

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Cell Host & Microbe

@cellhostmicrobe

6 years

Mitochondria pack a punch to #MRSA : #Mitochondria -derived vesicles deliver #antimicrobial reactive oxygen species to control phagosome-localized #Saureus . Now online @cellhostmicrobe

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Cell Host & Microbe

@cellhostmicrobe

2 years

Our June issue is now live with a Focus on #Microbiome and Metabolism. Great food for thought in store…

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Cell Host & Microbe

@cellhostmicrobe

8 months

Its new issue day at Cell Host & Microbe! Our September cover features precision #microbiome engineering when HMO-fed B. infantis (microbial “seeds”) are introduced into adult, antibiotic-perturbed gut microbiomes

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Cell Host & Microbe

@cellhostmicrobe

10 months

The vagina question: Can maternal vaginal fluid impact infant gut microbiome & neurodevelopment? Jaspan, Happel& @bostonvaginadoc discuss report that vaginal microbial transfer from mom to infant postdelivery may alter infant microbiota & neurodevelopment

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Cell Host & Microbe

@cellhostmicrobe

2 years

Featured Article: Dietary changes leave genetic signature in #microbiota . B. theta evolves under nutritional changes. #Diet changes increase intraspecies diversity & mutations w/Western-style diet favor host mucus consumption @DapaTanja @KarinaXavierLab

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Cell Host & Microbe

@cellhostmicrobe

4 years

The skin #microbiota : Balancing risk/reward @elizgrice & @LFlowers_A discuss rewards of hosting microbial ecosystem on #skin , including protection from #pathogens & tuning of microenvironment. Conversely, skin residents can cause damage & promote disease

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32

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Cell Host & Microbe

@cellhostmicrobe

5 years

The social life of phages: New work in this issue uncovers widespread utilization of peptide communication in #phages infecting soil and pathogenic #bacteria . @AAvihail , Nitzan Tal, @SorekLab

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46

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Cell Host & Microbe

@cellhostmicrobe

2 years

#Phages & their satellites encode hotspots of #antiviral systems: @FrancoisRousset @dbikard & Depardieu show #Ecoli P2-like #phages & parasitic P4-like satellites carry diverse anti-phage systems. Notably, PARIS system induces abortive infection

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19

68

Cell Host & Microbe

@cellhostmicrobe

6 years

A #gut response to #sepsis : #Commensal #microbes induce serum IgA responses that protect against polymicrobial sepsis. New @cellhostmicrobe

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41

70

Cell Host & Microbe

@cellhostmicrobe

2 years

Carbon source competition limits : #Ecoli provides colonization resistance against #Salmonella by competing for carbon source galactitol w/specific #microbiota . Lachnospiraceae consuming C5/C6 sugars also play roles @baerboletta

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21

68

Cell Host & Microbe

@cellhostmicrobe

3 years

Success of SARS-CoV-2 vaccines & challenges ahead: In light of effective #SARSCoV2 #vaccines , this review examines a selection of issues related to the evolving story, including challenges ahead as virus circulates & vaccines are rolled out globally

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43

66

Cell Host & Microbe

@cellhostmicrobe

6 years

#Phage involvement in #IBD ? New work in murine #colitis model reveals a disease-associated bacteriophage community. From Duerkop Lab @Manuel_Kleiner @LHooperLab @NatureMicrobiol

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