Clovibactin, a new antibiotic isolated from soil bacteria, blocks bacterial cell wall synthesis by targeting essential peptidoglycan precursors, allowing it to kill drug-resistant bacterial pathogens...

The foundational research recognized by this year’s Lasker Basic Science Research Award “for discoveries concerning the integrins—key mediators of cell-matrix and cell-cell adhesion in physiology and...

RNAs present on the outer cell surface have been recently identified in mammalian cells, but the functional significance of these cell surface RNAs hasn’t been clear. This study reveals roles of cell...

Glucose is the main source of energy for cells. In this issue of Cell, a study now shows that glucose has additional non-energetic functions, acting as a biomolecular cue that regulates alternative...

mRNA transcription in budding yeast increases with cell size due to the equilibrium kinetics of dosage-limiting RNA polymerase II and the genome. This is then supported by a global increase in mRNA...

Natural killer (NK)-based therapies against cancer are emerging, but the understanding of NK cell functions needs to be completed to optimize these treatments. In this issue, Pan et al. (2022) show...

Tumor-associated macrophages (TAMs) fuel the evolution of the cancer ecosystem. This review discusses recent advances in our knowledge of macrophages in the tumor microenvironment, broadly covering...

Development of SUM-PAINT, an approach that is capable of potentially unlimited super-resolution multiplexing, enables rapid visualization of distinct synapse types at single-molecule resolution.

Enhanced efflux of PGD2 across the BBB during prolonged sleep deprivation induces a cytokine-storm-like syndrome via the PGD2/DP1 axis. Sleep deprivation in mice that involves disruption of REMS and...

Transcriptional condensate dynamically interacts with the gene locus, resulting in a burst increase when in proximity and a return to basal bursting when the condensate moves away.

The analysis of multi-tissue gene expression signatures associated with longevity across mammalian species and their interaction with biomarkers of aging and signatures of lifespan-extending interv...

We are the editors of a science journal, committed to publishing and disseminating exciting work across the biological sciences. We are 13 scientists. Not one of us is Black. Underrepresentation of...

The field of cancer metabolism provides us with a framework to understand basic cellular metabolic principles and pathways.

The story of p53 is illuminating. Despite widespread attention, the tumor-suppressive functions of wild-type p53 or the oncogenic activities of its cancer-associated mutants are still not, and our...

Queosine (Q) is a modified nucleoside present in tRNA anticodons. Identification and characterization of two vertebrate Q-glycosylases unveil new regulatory mechanism in protein translation and...

RNAs present on the outer cell surface have been recently identified in mammalian cells, but the functional significance of these cell surface RNAs hasn’t been clear. This study reveals roles of cell...

An analytical resource of post-translational modifications from over 1,000 patients across 11 cancer types reveals pan-cancer changes involved in hallmark cancer processes and reveals potential new...

In humans, senescent fibroblasts do not seem to increase with advancing age in the elderly because their populations are controlled by cytotoxic CD4+ T cells. The expression of T cell-activating...

Sekine et al. provide a functional and phenotypic map of SARS-CoV-2-specific T cells across the full spectrum of exposure, infection, and COVID-19 severity. They observe that SARS-CoV-2 elicits...

Tumor-associated macrophages (TAMs) fuel the evolution of the cancer ecosystem. This review discusses recent advances in our knowledge of macrophages in the tumor microenvironment, broadly covering...

Decades of oncologic clinical use have demonstrated that cancer immunotherapy provides unprecedented therapeutic benefits. Tragically, only a minority of patients respond to existing immunotherapies....

Longo and Anderson synthesize and weigh the literature, from molecular mechanisms to epidemiology and spanning yeast to people, about what you should eat, how much you should eat, and when should you...

An analytical resource of post-translational modifications from over 1,000 patients across 11 cancer types reveals pan-cancer changes involved in hallmark cancer processes and reveals potential new...

The development of molecular couriers to selectively package, export, and recover RNA molecules within human cells is a significant challenge. In this issue of Cell, Horns et al. introduce cellular...

Longitudinal analysis of immune memory following mild COVID-19 elicits memory lymphocytes that persist and display functional hallmarks of antiviral immunity.