By integrating scRNA-seq datasets across 77 studies and 24 cancer types, in Nature, Gavish et al. uncover recurrent patterns of gene expression that explain a significant proportion of transcriptomic...

Senescence induces key phenotypic changes that can modulate immune responses. Four recent publications in Cancer Discovery, Nature, and Nature Cancer highlight how senescent cells (aged normal or...

Cytotoxic T cells are indispensable for the body’s fight against most cancers. In the current issue of Cancer Cell, Gaglia et al. reveal how changes in the tumor tissue architecture creating niches...

Among new treatment approaches for patients with cancer, few have accelerated as quickly as neoadjuvant immune checkpoint blockade (ICB). Neoadjuvant cancer therapy is administered before curative-...

The genetic changes during high-grade serous ovarian cancer metastasis have largely remained a mystery. Lahtinen et al. show that ovarian cancer metastasizes along three different evolutionary states...

Gonçalves et al. generate a comprehensive proteomic map of 949 human cancer cell lines across more than 40 cancer types. Proteomic data are integrated with multi-omic, drug response, and CRISPR-Cas9...

Mahadevan et al. demonstrate that the oncogenic KRASG12D inhibitor MRTX1133 reverses early and advanced PDAC growth and remodels the tumor microenvironment. MRTX1133 induces FAS expression in cancer...

By integrating scRNA-seq datasets across 77 studies and 24 cancer types, in Nature, Gavish et al. uncover recurrent patterns of gene expression that explain a significant proportion of transcriptomic...

Cholesterol is essential for the ability of cytotoxic T cells to eliminate cancer cells. In this issue of Cancer Cell, Yan et al. reveal how intra-tumoral cholesterol deficiency contributes to T cell...

Chen et al. perform single-cell and spatial transcriptomic analyses of multistage esophageal lesions and reveal gradual loss of ANXA1 expression in epithelial cells during ESCC development. Both...

Zhu et al. generated an autochthonous lung GEMM with high TMB using a hypermutator Pole allele. Data from these models and patient samples suggest that p53 status and mutational heterogeneity may...

Veatch et al. identify the phenotype of tumor-specific conventional CD4+ T cells infiltrating human melanoma and find these cells form distinct functional states resembling T follicular helper cells...

Liang et al. catalog pan-cancer DNA methylation with concordant transcriptional and translational changes, revealing lineage-specific epigenetic driver FGFR2 hypomethylation in uterine corpus...