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Cell Reports Medicine

21 days

This month, we are featuring a small collection of articles looking at the impact of the gut microbiome on responses to immunotherapy. The cover art depicts a purple ribbon made of the different microbes that can be found in the gut microbiome. Cover art by Naola Leconte.

Apr 16, 2024 Volume 5, Issue 4

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Cell Reports Medicine

@CellRepMed

4 years

Our first three articles are now accessible online and you are the first to read them. We can't wait to share more thought-provoking translational and clinical research with you!

Access the first online papers from Cell Reports Medicine

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@CellRepMed

2 years

On this month's cover: a crowdsourced challenge to develop machine-learning algorithms that use drug-perturbed transcriptome data to rapidly predict drug targets on a proteomic scale. @practically_sci @allawayr @ben_szalai @JulioSaezRod @sagebio @dr_e_a_m @IRBBarcelona

Read the full paper from Douglass et al.

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Cell Reports Medicine

@CellRepMed

4 years

Here it is! Issue #1 is online! Join @CellRepMed community where translational and clinical scientists interact and inspire each other to profoundly impact our health and the diseases that threaten it.

Read Cell Reports Medicine issue #1

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@CellRepMed

2 years

Now @CellCellPress : Phage treatment of an individual with cystic fibrosis, advanced lung disease, and M. abscessus infection enables a subsequent successful lung transplant. @JerryNick_CO @DedrickRebekah @GHatfull

Read the full paper at Cell

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Cell Reports Medicine

@CellRepMed

5 years

Introducing Cell Reports Medicine, new #OA journal from @CellPressNews publishing original #Research that ranges from exciting concepts in #HumanBiology , #Health and #Disease to all phases of #Clinical work. Follow us for updates from the #translational and #medical communities!

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Cell Reports Medicine

@CellRepMed

4 years

Cell Reports Medicine has launched and is open for submissions. Find out more:

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Cell Reports Medicine

@CellRepMed

4 years

Issue #6 is out! Read the latest translational and clinical research on #RegenerativeMedicine #microbiota #RespiratoryImmunity #InfluenzaVirus #wastewater #epidemiology #immunity #HIVcure #HumanGenetics #reproduction and more!

Read Cell Reports Medicine issue #6

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Cell Reports Medicine

@CellRepMed

2 years

#AdipoAtlas : A reference lipidome of human white adipose tissue through analyses of lipid compositions in lean and obese states for subcutaneous and visceral depots. Authors identify several key events of lipidome remodeling in obesity. @FedorovaLab @MikeLangePHD .

Read the full paper from Lange et al.

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Cell Reports Medicine

@CellRepMed

3 years

Welcome to our 12th issue! Researchers broaden our view on drug-associated #cardiotoxicity , #probiotics in preterm infants, and surgical approach to #GastricCancer . We round out with more on #InfectiousDisease as well as other #TranslationalResearch and #ClinicalResearch areas.

Read the latest issue of Cell Reports Medicine

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Cell Reports Medicine

@CellRepMed

1 year

Online now: Inactive disease in patients with lupus is linked to autoantibodies to type I interferons that normalize blood IFNα and B cell subsets

Inactive disease in patients with lupus is linked to autoantibodies to type I interferons that...

Bradford et al. characterize the prevalence of anti-IFNα-Abs in patients with SLE and their association with serum levels of IFNα, clinical parameters, and B cell abnormalities. Patients with SLE...

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@CellRepMed

4 years

Proteogenomic characterization of ovarian high-grade serous #cancer implicates mitotic kinases, replication stress in observed chromosomal instability @NCI_CSSI #CellPressOncology @biodataganache #ovariancancer

Read the full paper from Rodland et al.

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@CellRepMed

3 years

A complete map of #SARSCoV2 mutations that escape binding by the LY-CoV555 Ab & cocktail with LY-CoV016. Maps highlight high-frequency mutations that may affect LY-CoV555 efficacy & enable interpretation of future effects on this Ab. @tylernstarr @jbloom_lab @fredhutch @HHMINEWS

Read the full paper from Starr et al.

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Cell Reports Medicine

@CellRepMed

3 years

94% of Healthcare workers vaccinated with #SputnikV #Vaccine showed fast antibody responses to #SARSCOV2 after one dose, and there is no evident benefit of using a second dose in previously infected individuals. A clinical study by Andres Rossi, Diego Ojeda et al. @GamarnikLab

Read the full paper from Rossi et al.

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@CellRepMed

3 years

Researchers gain insights into crosstalk between #Cancer and immune cells during #melanoma #immunotherapy . Complex phenotype of tumor immune infiltrates combined with genomic features of tumor cells are relevant for determining clinical outcomes.

Read the full paper from Anagnostou et al.

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Cell Reports Medicine

@CellRepMed

1 year

Online now: Spatial heterogeneity of infiltrating T cells in high-grade serous ovarian cancer revealed by multi-omics analysis

Spatial heterogeneity of infiltrating T cells in high-grade serous ovarian cancer revealed by...

Yang et al. conduct a multi-omics study and identify two immune “cold” patterns in ovarian cancer: ovarian lesions with tumor-specific but exhausted and low-infiltrated T cells and omental lesions...

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Cell Reports Medicine

@CellRepMed

4 years

. @BrodinPetter lab present a systems-level, longitudinal study of 37 #COVID19 patients monitored from acute to recovery phases. They identify cell-protein dependencies & co-regulated features, as well as a shared immunological trajectory during recovery from severe COVID19.

Read the full paper from Rodriguez et al.

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Cell Reports Medicine

@CellRepMed

3 years

Researchers compare early-life infant gut microbiota by delivery mode. Results suggest early colonization by Bacteroides regardless of delivery mode, but loss of Bacteroides by 2 weeks in C-section-delivered infants, whether or not exposed to the vagina in labor. @MoranYassour

Read the full paper from Mitchell et al.

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Cell Reports Medicine

@CellRepMed

3 years

Researchers demonstrate in nonhuman primates that mucosal respiratory delivery of BCG or MTBVAC induces trained #immunity more efficiently compared to standard intradermal vaccination. #tuberculosis @bprc_eu

Read the full paper from Vierboom et al.

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Cell Reports Medicine

@CellRepMed

4 years

Welcome to our issue #5 ! Access the latest research on #precisiononcology , #tumorigenesis , #humanimmunology , #BCG , #microbiota , #probiotic , #leukemia , #drugdevelopment , #cardiacsafety , and more!

Read Cell Reports Medicine issue #5

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Cell Reports Medicine

@CellRepMed

3 years

Researchers show that pulmonary immunization with the MTBVAC confers a local mucosal antigen-specific signature that has been previously associated with protection from #tuberculosis infection and disease in rhesus macaques. @bprc_eu

Read the full paper from Dijkman et al.

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Cell Reports Medicine

@CellRepMed

3 years

We invite you to read our open access collection on #TranslationalCancer and #ClinicalOncology research, covering recent advances in #CancerTherapies and #DiagnosticBiomarkers , #CancerImaging , #immunotherapy , #PrecisionOncology , and other areas.

Read the collection

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Cell Reports Medicine

@CellRepMed

4 years

Taking a break from the news to highlight some cool biology! Shi et al use human #iPSC -derived brain #organoids to model the impact of congenital #HCMV on brain development

Read the full paper from Shi et al.

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Cell Reports Medicine

@CellRepMed

3 years

New issue! Research on acute myeloid #leukemia , #immunoediting , and SARS-CoV-2, plus perspective on using antibody testing to estimate COVID-19 prevalence, commentary on physician-scientists and the pandemic, and other #translationalresearch and #clinicalresearch .

Read our February issue

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Cell Reports Medicine

@CellRepMed

3 years

Researchers show that SARS-CoV-2-specific memory CD4 and CD8 T cells exposed to the ancestral strain by infection or vaccination effectively recognize the variants B.1.1.7, B.1.351, P.1, and CAL.20C. @aetarke @Alba_Grifoni @profshanecrotty @Dani6020 @ljiresearch

Read the full paper from Tarke et al.

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Cell Reports Medicine

@CellRepMed

4 years

Researchers from @bertoletti_lab demonstrate that HDV co-infection boosts HBV epitope presentation on HBV/HDV and mono HBV infected hepatocytes. Anti-HBV efficacy of T cells engineered with T cell receptors is enhanced by HDV. #Hepatitis #Immunology

Read the full paper from Tham et al.

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Cell Reports Medicine

@CellRepMed

3 years

Welcome to the final issue of Cell Reports Medicine for 2020! We hope you enjoy the diverse collection of #translationalresearch and #clinicalresearch we offer this month. Have a merry, healthy, and bright holiday season!

Read our last issue for 2020

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Cell Reports Medicine

@CellRepMed

8 months

Online now: Small intestine vs. colon ecology and physiology: Why it matters in probiotic administration

Small intestine vs. colon ecology and physiology: Why it matters in probiotic administration

Jensen et al. provide a detailed review unfolding how the physiological and anatomical differences between the small and large intestine affect gut microbiota composition, function, and plasticity....

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Cell Reports Medicine

@CellRepMed

2 years

In a randomized, double-blind, placebo-controlled #clinicaltrial , Hagemann, @Filip_Knop and colleagues from @HerlevGentofte and @UCPH_health demonstrate that exogenous LEAP2 reduces postprandial glucose excursions and food intake in healthy men.

Read the full paper from Hagemann et al.

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@CellRepMed

3 years

. @anu_goenka and @alice_ahalliday compared #SARSCoV2 infections in babies with their parents: infants show high serum levels of #neutralizing anti-spike #IgG but restrained spike-specific IFN-γ, suggesting these protect against severe #COVID19 . From lab @laura_rivino @adamhfinn

Read the full paper from Goenka et al.

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Cell Reports Medicine

@CellRepMed

4 years

Issue #2 is here - an exciting collection of papers offering insights on #biomarkers , #diagnostics , #therapeutics , #vaccinations , #infectiousdisease , and more!

Read Cell Reports Medicine issue #2

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Cell Reports Medicine

@CellRepMed

3 years

Compared with control individuals, those with COVID-19 with neurologic symptoms have divergent immune responses between the CNS and periphery, including high rates of antineural autoantibodies in their CSF. @ShelFarFar @EricSongg @CMBartley @Samplease @NeurologyYale @YaleMed

Read the full paper from Song et al.

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@CellRepMed

2 years

Now @ImmunityCP : @EOSaphire and @SetteLab present a Perspective discussing approaches for vaccine development against #SARSCoV2 variants & other viruses. Eliciting both humoral and cellular responses could provide the best chance to defend against the next pandemic.

Read the full Perspective at Immunity!

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@CellRepMed

3 years

A systems biology approach identifies alterations in cholesterol & bile acid metabolism in #Alzheimer 's disease. Expression of alternative bile acid & neural cholesterol clearance pathway + transporters of taurine & bile acids suggests gut-brain axis plays role in AD. #Neurology

Read the full paper from Baloni et al.

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@CellRepMed

4 years

Read the Q&A of our Editor-in-Chief @DrSaraHam , sharing her vision and excitement of bringing together scientists and clinicians to foster deeper engagement between these communities and to strengthen the growth and development of both ends of the research spectrum.

What researchers and clinicians can expect from Cell Reports Medicine?

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Cell Reports Medicine

@CellRepMed

2 years

Now @ImmunityCP : How chronic tissue inflammation results in insulin resistance & impaired secretion, glucose intolerance & T2DM. Authors discuss inflammation's impact, current therapeutic options to treat metabolic disease, and the potential of immune-modulatory approaches.

Read the full paper at Immunity.

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@CellRepMed

3 years

Viral infection can lead to #diabetes : infection of pancreatic beta cells with the enterovirus #coxsackievirus B type 4 in mice led to DNMT1-mediated Pdx1 silencing, and subsequently to a MODY4-like diabetes.

Read the full paper from Bernard et al.!

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Cell Reports Medicine

@CellRepMed

3 years

Overgaard, @DanielJDrucker and colleagues analyze oral vs. parenteral routes of administration of semaglutide and found that circulating levels of this #GLP1 receptor agonists predict outcomes in people with type 2 #diabetes

Read the full paper from Overgaard et al.

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Cell Reports Medicine

@CellRepMed

4 years

In this challenging time we are thankful to our authors, advisers, readers, editors, and the whole team for their love and devotion to science! We're 2 hours away from publishing our first issue and that wouldn't have been possible without the efforts of a great community! 👏

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Cell Reports Medicine

@CellRepMed

4 years

Researchers studied #cysticfibrosis lung transplant pts. They report that Pseudomonas-infected allograft airway cells demonstrate suppression of interferon genes and increases in alpha-diversity & mucoid forms; differential DNA methylation might contribute to this phenotype.

Read the full paper from Dugger et al.

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Cell Reports Medicine

@CellRepMed

3 years

Researchers determine how drug transporters affect the efficacy of docetaxel against several intracranial tumor models with various levels of BBB integrity and show that ABC transporters can restrict drug efficacy even when tumor vessels are leaky. @NKI_nl #drugdiscovery

Read the full paper from de Gooijer et al.

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Cell Reports Medicine

@CellRepMed

2 years

Now @cellhostmicrobe : In a randomized intervention trial of extremely preterm & very low birth weight infants, researchers show that a multi-strain mix accelerated microbiome maturation to resemble that of full-term infants & improved metabolic and immune parameters. @ArrietaLab

Read the full paper at Cell Host & Microbe

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Cell Reports Medicine

@CellRepMed

3 years

Researchers present an automated system that comprises organoid fabrication, manipulation, and drug evaluation functions in sequence, aiming to fulfill the personalized medicine goal of 1-week high-throughput screening for cancer patients. #oncology #PrecisionMedicine

Read the full paper from Jiang et al.

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Cell Reports Medicine

@CellRepMed

4 years

We are publishing our first papers today! They will be available online just in a few hours at . Another milestone reached in a difficult times. Let's share the little joys of life!

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Cell Reports Medicine

@CellRepMed

3 years

Our first issue for 2021 is online and freely accessible! We will continue to work on delivering the latest #translationalresearch and #clinicaladvances across all #biomedical fields. We hope you enjoy this month's selection. Cover by Mark de Gooijer @NKI_nl

Read our January issue

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Cell Reports Medicine

@CellRepMed

3 years

In vitro study from Rother and colleagues from @radboudumc show #hydroxychloroquine dampens the trained innate immune response to #interferons and viral stimuli in #PBMCs #trainedimmunity #innateimmunity

Read the full paper from Rother et al.

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Cell Reports Medicine

@CellRepMed

1 year

Our December issue is here! On the cover: Artificial intelligence has transformed research and is poised to do the same for clinical care. To reflect the contribution and impact of AI on science, we present a special issue on AI in medicine. Cover art by Kip Lyall.

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Cell Reports Medicine

@CellRepMed

3 years

#dihydroceramides plasma levels are associated with non-alcoholic liver disease #NAFLD in #Type2Diabetes - by @FerrPascal2 , @FFoufelle and colleagues from @CRCordeliers @Inserm @MedecineSU @Sorbonne_Univ_ @ICAN_Institute

Read the full paper from Carlier et al.

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@CellRepMed

10 months

Online now: Bacterial clade-specific analysis identifies distinct epithelial responses in inflammatory bowel disease

Bacterial clade-specific analysis identifies distinct epithelial responses in inflammatory bowel...

D’Adamo et al. combines tissue-specific microbial culturing, high-resolution mucosal sequencing, and in vitro validation to reveal key bacterial clades associated with regulation of cellular pathways...

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@CellRepMed

4 years

Ma et al. @WhiteheadInst combine β cell specific expression of a model antigen CD19 and anti-CD19 chimeric antigen receptor T (CAR-T) cells to understand T-cell mediated immune impact on human pancreatic β cells #StemCells #RegenerativeMedicine

Read the full paper by Ma et al.

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@CellRepMed

3 years

BMI-discordant monozygotic #twin pairs’ adipose tissue and skeletal muscle show insights in #AdiposeTissue metabolic alterations contributing to #obesity . A study by Vander Kolk, Saari, @DrPietilainen and colleagues from @HelsinkiUniMed

Read the full paper from Van Der Kolk.

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Cell Reports Medicine

@CellRepMed

3 years

Issue 8 is now out! Read the latest research in Cell Reports Medicine.

Issue 8 now online! Check out this month's research.

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Cell Reports Medicine

@CellRepMed

3 years

Researchers studied P. falciparum infection in Australian adults and report an association between #Th2 #Tfh activation and induction of functional antibodies against #malaria . @DrMichelleBoyle @QIMRBerghofer

Read the full paper from Chan et al.

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Cell Reports Medicine

@CellRepMed

3 years

Researchers demonstrate that IL-22 can attenuate intestinal inflammation by promoting epithelial regeneration in a neonatal mouse model of necrotizing enterocolitis. #NEC @mistygoodlab @WUSTLmed

Read the full paper from Mihi et al.

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Cell Reports Medicine

@CellRepMed

2 years

Our 12th and last issue for 2021 is online and freely accessible.

Explore the full issue

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Cell Reports Medicine

@CellRepMed

2 years

Now @CellStemCell : Researchers review current challenges in multicellular cardiac organoids and tools for assessing cardiac organoids for clinical application. @Joseph_C_Wu @hyeonyu_kim @GVNlab @StanfordCVI

Progress in multicellular human cardiac organoids for clinical applications

Recent advances and current challenges in multicellular cardiac organoids and tools for assessing cardiac organoids for clinical application are discussed.

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@CellRepMed

4 years

. @McGuire_Lab show that passive delivery of an anti-EBV neutralizing antibody protects against lymphocryptovirus challenge in two animal models.

Read the full paper from Singh et al.

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Cell Reports Medicine

@CellRepMed

2 years

Multi-omic analysis in trauma patients reveals massive systemic cellular content release and simultaneous blood constituent consumption. Patient endotypes differ in outcomes & responses to early plasma admin. @PittTTMRC @TheBilliarLab @macky_neal @Jjasonsperrymd @JunruWu1

Read the full paper from Wu et al.

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3 years

KRAS, an oncogenic driver in #lungcancer , is known as an “undruggable” target. Different strategies are under investigation to indirectly and directly target KRAS Clinical trials of small-molecule inhibitors report promising interim results. @DanaFarber @cityofhope

Read the full paper!

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Cell Reports Medicine

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1 year

On the cover: Immune cells attacking tumor cells. This issue contains several papers that provide insight into the tumor immune microenvironment and responses to immune checkpoint inhibitors. Cover credit: Meletios

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Cell Reports Medicine

@CellRepMed

4 years

Our OCTOBER ISSUE is online and it happens to publish during #OAweek . This month we feature a new batch of fascinating #OpenAccess research covering #infectiousdisease , #glioblastoma diagnostics, #cancer , #IBS , #coxsackievirus , and #Parkinsons dementia. Enjoy reading!

Read Cell Reports Medicine issue #7

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Cell Reports Medicine

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4 years

Srinivasan et al. analyse circulating #microRNAs derived from placental tissue to identify women at risk for #preeclampsia

Read the full paper from Srinivasan et al.

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Cell Reports Medicine

@CellRepMed

4 years

In this article Marinaik et al. provide insights into vaccine-induced multifaceted mucosal T cell immunity with implications in the development of vaccines against #RespiratoryPathogens #RespiratoryImmunity

Read the full paper by Marinaik et al.

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2 years

Researchers id peripheral blood transcriptional profiles associated with mortality in critically ill COVID-19 pts. SARS-CoV-2-infected macrophages in lung express high levels of CXCL10 @tonyrcillo @KitsiosMd @BcellBruno @Vignali_Lab

Read the full paper from Cillo et al.

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Cell Reports Medicine

@CellRepMed

1 year

Online now: Neutrophil Profiles of Pediatric COVID-19 and Multisystem Inflammatory Syndrome in Children. @bpboribong @LaelYonker @ragoninstitute @MGH_RI @MGH_Mucosalists

Neutrophil profiles of pediatric COVID-19 and multisystem inflammatory syndrome in children

Boribong, LaSalle, et al. extensively profile gene expression, protein production, and functionality of neutrophils from children with acute COVID-19 or multisystem inflammatory syndrome in children...

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@CellRepMed

3 years

Researchers study #Castleman disease. Pairing a traditional registry with a patient-powered approach allows for clinical insights supporting treatment guidelines. De-identified linkage to a biobank enables #translational discoveries. #rarediseases @DavidFajgenbaum @CureCastleman

Read the full paper from Pierson et al.

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Cell Reports Medicine

@CellRepMed

2 years

Resolving SARS-CoV-2 CD4+ T cell specificity via reverse epitope discovery @pogorely @elisarosix @PGTimmune @Minervina_Asya @RMettelman @an_franke

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Cell Reports Medicine

@CellRepMed

4 years

Kaufman et al. report pharmacokinetic, pharmacodynamic & safety data from a phase 1 multiple, ascending dose study in T2DM of AKR-001, an Fc-FGF21 analog. AKR-001 exhibits positive trends in various metabolic markers. #diabetes @akerotx

Read the full paper from Kaufman et al.

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@CellRepMed

2 years

Now @cellhostmicrobe : Researchers review how the knowledge of diet-microbiome-host interactions can validate, refine, and innovate dietary guidelines. They advocate for the systematic integration of microbiome science into nutrition research to further improve healthy eating.

Read the full Review at Cell Host & Microbe

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@CellRepMed

3 years

Now at @CellStemCell : researchers detect SARS-CoV-2 antigens in cadaver samples and eye organoid cultures suggesting that SARS-CoV-2 can directly infect the eye. They implicate the limbus as a portal for viral entry. @blenkinsoplab @virusninja @skyleruhl @AnneZebitz , @rsmsmllr

Read the full paper at Cell Stem Cell

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@CellRepMed

2 years

Now @Cell_Metabolism : researchers "review the cellular and physiological mechanisms responsible for the link between excess adiposity and type 2 diabetes and the therapeutic metabolic effects of weight (fat) loss."

Why does obesity cause diabetes?

Klein et al. examine the cellular and physiological mechanisms that explain why people with obesity develop metabolic dysfunction and type 2 diabetes. They also review the effects of weight loss,...

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@CellRepMed

3 years

Co-blockade of PD-1 and CTLA-4 increases benefits of #cancer #immunotherapy but also toxicity. Researchers constructed a bispecific DART molecule to deliver safer and potentially more effective co-blockade by targeting CTLA-4 inhibition to tumors.

Read the full paper from Berezhnoy et al.

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@CellRepMed

3 years

Researchers use strain-resolved metagenomics to characterize preterm & full-term infant gut-microbiome succession during the first year of life. @ClareLou9 @BanfieldLab

Read the full paper from Lou et al.

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@CellRepMed

3 years

Researchers model a vascular tumor called pseudomyogenic hemangioendothelioma) using #iPSCs that express the SERPINE1-FOSB translocation @LUMC_Leiden #oncology #vascular

Read the full paper from IJzendoorn et al.

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Cell Reports Medicine

@CellRepMed

2 years

Researchers provide data on antibody response against #SARSCoV2 after heterologous vaccine schemes, including non-replicating adenovirus, mRNA and inactivated vaccines. Many heterologous combinations are equivalent or superior to homologous schemes.

Read the full paper from Pascuale et al.

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3 years

Now @cellhostmicrobe : Researchers explain herd immunity and why "vaccination is the best way to attain herd immunity responsibly." @BillHanage @maryebushman @bradfordptaylor

Read the full paper at Cell Host & Microbe

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Cell Reports Medicine

@CellRepMed

2 years

Online now: A comparative characterization of SARS-CoV-2-specific T cells induced by mRNA or Inactive virus COVID-19 Vaccines

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Cell Reports Medicine

@CellRepMed

3 years

Researchers report decline of Fc-dependent antibody functions against #SARSCoV2 spike in #Covid_19 convalescent pts up to 149 days post-infection. Unlike neutralization activity, plasma ADCC and ADP responses sustained in the majority of subjects. @TheDohertyInst @UniMelbMDHS

Read the full paper from Lee et al.

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Cell Reports Medicine

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1 year

The new issue is now online! The cover image shows retinal fundus photographs collected from real-world settings flow into an intelligent image sorting system. This system can be implemented from model development to real-world application of medical artificial intelligence.

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2 years

On this month's cover: in 17 people with type 1 diabetes, pancreatic endoderm cells in an investigational subcutaneous device (VC-02) achieved engraftment and insulin expression in 63% of units at 3–12 months post-implant. @UAlberta @AlbertaDiabetes

Read the full paper from Shapiro et al.

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@CellRepMed

3 years

Researchers analyze response of colorectal liver metastases (CRLM) to chemotherapy in 3D organotypic tumor slices by single-cell RNA-seq. They find 2 subtypes of CRLM that express different immune checkpoint ligands and respond differently to chemotherapy. #coloncancer @UWSurgery

Read the full paper from Jabbari et al.

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@CellRepMed

3 years

Authors consider the impact of SARS-CoV-2 mutations on T cell responses. Mutations could be neutral or result in either loss or gain of predicted epitopes depending on HLA type. @ImperialInfect @ImperialImmuno @BoytonRosemary @Daltmann10

Read the full paper from Altmann and colleagues.

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@CellRepMed

3 years

Gao and colleagues from @genentech demonstrate #osteopontin is a marker for #lungfibrosis in patients with #SystemicSclerosis and show in #macrophages that immune complexes induce the secretion of osteopontin via MCSF and IL6 @Thiru21 @sclerodermaUM #IPF

Read the full paper from Gao et al.

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@CellRepMed

3 years

Researchers show that the protective live attenuated tetravalent dengue vaccine stimulates early B and T cell responses to promote durable memory and neutralizing antibodies. @SeanDiehl2 @uvmcmb #vaccine #Immunology

Read the full paper from Tu et al.

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@CellRepMed

3 years

Integrated #microbiome #metabolome analysis by @Izhak_Levi , Anat Achiron, @Segal_Eran and colleagues from @WeizmannScience reveals reduced levels of indolelactate and its producing bacteria in #MultipleSclerosis

Read the full paper by Levi et al.

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4 years

. @LianaNobre3 , @vijayvijay1979 & colleagues analyze a cohort of 93 WNT-activated #medulloblastoma & report maintenance chemotherapy is the strongest relapse predictor. @SickKidsNews @Sickkids @MBPatUofT @UofTIMS #oncology #braintumor #pediatrics

Read the full paper from Nobre et al.

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@CellRepMed

3 years

As scientists and physicians, we all trained. But how many of us did so through a global pandemic? We present 11 voices from current trainees who reflect on how the pandemic altered their research, practice, and learning and, in the process, changed them.

11 trainees talk about training during a pandemic.

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3 years

Today, we highlight work from @MSpencerUCLA and colleagues who use a small molecule to treat limb-girdle muscular dystrophy by activating signaling pathways and transcriptional programs. @UCLANeurology @dgsomucla #MuscularDystrophy #LGMD #RareDisease

Read the full paper from Liu et al.!

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4 years

Congratulations to Emmanuelle Charpentier and Jennifer A. Doudna on their well-deserved #NobelPrize2020 in #Chemistry “for the development of a method for genome editing” and for being an inspiration to young female scientists around the world! #GenomeEditing

The Nobel Prize

@NobelPrize

4 years

“My wish is that this will provide a positive message to the young girls who would like to follow the path of science, and to show them that women in science can also have an impact through the research that they are performing.” - 2020 Chemistry Laureate Emmanuelle Charpentier.

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3 years

Researchers identify altered NF-κB signaling with aging in the transcriptional profiles of vaccine-induced circulating Tfh responses after influenza vaccine and demonstrate the use of these cells as cellular biosensors of the underlying immune state. @RaminHerati @EJohnWherry

Read the full paper from Herati et al.

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@CellRepMed

4 years

In a phase-I HIV vaccine trial, Basu et al. show a robust response of HIV Env gp120-specific peripheral blood plasmablasts immediately after vaccination @KobieJ50

Read the full paper from Basu et al.

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@CellRepMed

2 years

Now @Cancer_Cell : An immunotherapy strategy using CAR-T cells for leukemia by increasing binding avidity on both sides of the synapse through pharmacologic enhancement of tumor antigen density with azacitidine and via hinge modification on the T cell. @MarcelaMaus @Mark_Leick

Read the full article at Cancer Cell

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@CellRepMed

4 years

Welcome to our issue #3 ! Read the latest research on #HIV , #immunogenicity , #antibody , #neutralizingantibody , #vaccine , #colorectalcancer , #cancerbiomarkers , #medulloblastoma , #immunotherapy , and more!

Read Cell Reports Medicine issue #3

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4 years

Researchers from @SanRaffaeleMI apply #MachineLearning to transcriptional profiles of peripheral immune cells from ~ 300 pts with #MultipleSclerosis and healthy controls. Models display high accuracy on the independent test set and identify disease state and stage.

Read the full paper from Acquaviva et al.

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1 year

The new issue is now online! The image depicts a child picking hematopoietic stem cell flowers from their RNA stems to assemble a bouquet that symbolizes RNA splicing. Broken stems signify the aberrant splicing patterns in leukemia stem cells which are targeted by Rebecsinib bees

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@CellRepMed

2 years

Online now: Multiple BCG vaccinations for prevention of COVID-19 and other infectious diseases in Type 1 diabetes. @Faustmanlab

Multiple BCG vaccinations for the prevention of COVID-19 and other infectious diseases in type 1...

In a randomized, double-blinded, placebo-controlled phase 2/3 trial, Faustman et al. investigate the safety and efficacy of multiple doses of the more than 100-year-old Bacillus Calmette-Guérin (BCG)...

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2 years

Researchers develop nanoparticles displaying the viral gH/gL glycoprotein complex that elicit potent neutralizing antibody responses capable of protecting against lethal Epstein-Barr virus challenge in humanized mice. @McGuire_Lab , @Harman_M , @KingLabIPD , @veeslerlab , @FredHutch

Read the full paper from Malhi et al.

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2 years

Now @CellStemCell : Researchers evaluate the modeling of neurodegenerative diseases using #iPSCs . They highlight challenges to exploiting iPSC technology's full potential in neurodegenerative diseases. @giacomelli_eli @BVahsen @studerl

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@CellRepMed

2 years

. @Virusnerdette spotlights recent research in @cellhostmicrobe – laboratory mice exposed to pathogens from pet-store mice exhibit impaired humoral immunity to influenza vaccination and display gene expression signatures that more authentically reflect human vaccine responses.

Read the full Spotlight from Lynda Coughlan.

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@CellRepMed

3 years

Crowdsourcing to develop methods to predict gestational age and preterm birth from longitudinal multi-omics data. Blood RNAs predict ultrasound-based gestational age, and molecular changes precede the diagnosis of spontaneous preterm birth in asymptomatic women. @AdiTarca

Read the full paper from Tarca et al.

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Cell Reports Medicine

@CellRepMed

3 years

Looking back at our first year: published 115 original research articles and reviews of authors from 48 countries, downloaded 568k times from 202 countries. We thank all of you who drive science forward - researchers, authors, advisory board members, reviewers, and readers 👏

Read the editorial: A look back at our first year

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