Adipose tissue dysfunction plays an important role in cognitive impairment in type 2 diabetes. Here, Wang et al. reported that EVs and their cargo miRNAs mediate adipose tissue-brain inter-organ...

Xue et al. concentrate on the roles and underlying mechanisms of Trp metabolism in health and disease. In addition, the clinical applications of Trp metabolism inhibitors are discussed. Xue et al....

By infusing 15 different 13C-isotope tracers, Hui et al. quantify metabolic fluxes in mice on either high-carbohydrate or ketogenic diet. Results include interconversion fluxes between circulating...

Circadian alterations are prevalent in patients with Alzheimer’s disease (AD). Whittaker et al. report circadian disruptions, which emerge at early pathology stages, in AD mouse models. The applica...

Stekovic et al. show in the clinic that alternate day fasting (ADF) is a simple alternative to calorie restriction and provokes similar improvements on cardiovascular parameters and body composition....

Mihaylova et al. summarize discussions at a recent NIH workshop focused on the regulation of healthy aging by dietary composition and feeding schedule and defined questions and challenges that must...

Crewe et al. report that adipocytes release sEVs containing damaged mitochondria in response to energetic stress, such as seen in chronic obesity. The sEV-associated mitochondria induce transient...

This review by Xiao et al. summarizes the metabolic targets for cancer treatment and provides an up-to-date overview of clinical trials targeting cancer metabolism. They decipher crucial factors that...

Ferrer et al. discover that the anti-cancer effects of a ketogenic diet are uncoupled from survival in mouse models of IL-6-producing cancers. Intratumoral ferroptosis causes a smaller tumor burden,...

Becker et al. discover that exercise induces muscle-residing Tregs through IL6Rα signaling. Mice lacking IL6Rα on T cells show defects in muscle Tregs upon exercise, more pronounced decline in muscle...

Gutierrez et al. provide a comprehensive overview of the gut microbiome, the basic circadian clock mechanism, and how circadian rhythms coordinate gut function, metabolism, and host-microbiome...

The composition of nutrients in the tumor microenvironment is a key determinant of anti-tumor CD8+ T cell response. In this issue of Cell Metabolism, Jiang and colleagues unveil that tumor-derived...

Health benefits of aerobic exercise are indisputable and are closely related to the maintenance of mitochondrial energy homeostasis and insulin sensitivity. Flockhart et al. demonstrate, however,...

Ibrahim et al. discover that mitochondrial (but not glycolytic) ATP regulates endothelial fatty acid uptake and transport. Endothelial mitochondria are closely juxtaposed to ER, and ATP locally...

Cheng et al. report that cancer-specific FH depletion accumulates fumarate in the tumor interstitial fluid and suppresses infiltrating CD8+ T cell activation and anti-tumor function. Increased TME...

Fernández-Vizarra et al. show the co-existence of two separated mitochondrial respiratory chain (MRC) organizations in human cells driven by distinct COX7A isoforms. The prevalence of either organi...

Tissue microarchitecture and cell composition are major determinants of organ function. Here, Bäckdahl et al. apply spatial transcriptomics to human white adipose tissue. This reveals that the tissue...

We designed a “metabolic elasticity” scoring system measuring an organism’s capacity to cope with and recover from metabolic fluctuations. With age and obesity, this elasticity notably diminishes,...

Klein et al. examine the cellular and physiological mechanisms that explain why people with obesity develop metabolic dysfunction and type 2 diabetes. They also review the effects of weight loss,...

Cheng et al. report that cancer-specific FH depletion accumulates fumarate in the tumor interstitial fluid and suppresses infiltrating CD8+ T cell activation and anti-tumor function. Increased TME...

Hochrein et al. report that inflammatory T cells express high levels of GLUT3. Ablation of GLUT3 curtailed Th17-cell-mediated immune responses and protected mice from autoimmune colitis and encepha...

Capelo-Diz et al. report that hepatic S-adenosylmethionine (SAMe), the principal methyl donor, acts as a metabolic sensor of nutrition to fine-tune the adaptive cellular responses to fasting by...

Mihaylova et al. summarize discussions at a recent NIH workshop focused on the regulation of healthy aging by dietary composition and feeding schedule and defined questions and challenges that must...

Mitochondrial complex I generates NAD+ and contributes to ATP production; however, which is necessary for brain function remains unknown. McElroy et al. demonstrate the yeast NDI1 protein, which...

Correia et al. show that muscle-secreted neurturin acts on muscle fibers and motor neurons to couple their characteristics in a functional way. This induces a shift toward a slow motor neuron...