Petter Brodin @BrodinPetter Twitter profile

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Petter Brodin

@BrodinPetter

2 years

Acute hepatitis in kids. We urge colleagues with access to samples (blood/liver tissue) to consider SARS-CoV-2 superantigen-mediated disease, potentiated by a second virus (AdV) 🧵1/

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Petter Brodin

@BrodinPetter

4 years

New from us: The immunology of MIS-C v.s Kawasaki disease and acute COVID-19. Online now in Cell:

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Petter Brodin

@BrodinPetter

2 years

6/ We should urgently investigate SARS-CoV-2 superantigen mediated disease, potentiated by an intestinal virus (AdV or other) as a possible mechanism of hepatitis. If confirmed, immunomodulatory treatments could be given and hopefully help.

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Petter Brodin

@BrodinPetter

4 years

The end of manual gating - Single-cell classification using learned phenotypes. New tool from Yang Chen in our team: code here:

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Petter Brodin

@BrodinPetter

2 years

#MISC and #LongCOVID - A SARS-CoV-2 Viral Superantigen Hypothesis by @ArditiMd et al:

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Petter Brodin

@BrodinPetter

2 years

How come #COVID19 is mostly mild in children? and at the same time, why do the rare hyperinflammatory syndrome #MISC affect mostly young people, and not the elderly? thread🧵and a hypothesis:

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Petter Brodin

@BrodinPetter

2 years

Most interesting aspect of this case is massive T cell infiltration and recovery after treatment with steroids. Fits w SARS-CoV2 super-ag mediated activation as a cause of hepatitis

Vanessa S. Lanziotti

@VSLanziotti

2 years

#Pediatric Acute Liver Failure Due to Type 2 Autoimmune Hepatitis assoc w/ #SARSCoV2 Infection:Case Report 🔹3 yo female 🔹Mild #COVID19 🔹Severe hepatitis 3 weeks later 🔹No #MISC criteria 🔹anti-LKM + 🔹responded to corticosteroids #PedsICU #MedEd

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Petter Brodin

@BrodinPetter

3 years

In 2011 I graduated as M.D and defended my PhD @karolinskainst Today, promoted to Professor of Pediatric Immunology - Immensely grateful to my family, my mentors and my amazing team members who made this possible #firstgen #academic #DoubleDoc

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Petter Brodin

@BrodinPetter

2 years

2/ @ArditiMd and colleagues first described a superantigen motif in SARS-CoV-2 and several groups have independently found T-cell skewing (TRBV11-2 expanded) in kids w #MISC , indicative of a superantigen-mediated inflammation.

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Petter Brodin

@BrodinPetter

1 year

CDC adds #COVID19 vaccines to the Childhood Immunization Schedule from 6 months: as recommended by @AmerAcadPeds and other experts

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Petter Brodin

@BrodinPetter

2 years

link to commentary paper:

Severe acute hepatitis in children: investigate SARS-CoV-2 superantigens

Recently, there have been reports of children with a severe acute form of hepatitis in the UK, Europe, the USA, Israel, and Japan.1 Most patients present with gastrointestinal symptoms and then...

www.thelancet.com

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Petter Brodin

@BrodinPetter

2 years

3/ Multiple reports have reported intestinal SARS-CoV-2 persistence and leakage of superantigens into the bloodstream trigger immune activation and possibly MIS-C in susceptible individuals, @laelyonker et al

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Petter Brodin

@BrodinPetter

3 years

New paper alert! How do microbes imprint immune systems early in life & determine risk of asthma, allergies and autoimmunity later in life? inspired by work from @ArrietaLab @finlaylab @tvatanen @Xavierlab and more?

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Petter Brodin

@BrodinPetter

2 years

4/ A recent energy allocation theory could explain mild COVID-19, viral persistence and MIS-C specifically in growing children and young people:

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Petter Brodin

@BrodinPetter

3 years

This 10yr old with big dreams would have never imagined being a professor at 39yrs today. Honored and grateful to @karolinskainst for amazing education and training. Made possible by incredible team members, mentors, friends and most importantly my brilliant wife. Thank you all

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Petter Brodin

@BrodinPetter

2 years

5/ Adenoviruses (AdV) sensitises mice to superantigen (Staph. SEB) mediated disease. AdV + SEB triggered acute hepatitis in mice, while AdV or SEB alone did not cause hepatitis:

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Petter Brodin

@BrodinPetter

3 years

Human immune systems can only be understood by studying diverse human populations. In @naturemethods we call for more inclusive human immunology research

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Petter Brodin

@BrodinPetter

2 years

1/ HGE () position paper on #LongCOVID #PACS . By focusing on the most severe patients, w severe organ damage/dysfunction following mild/moderate #COVID19 - we will search for genetic and immunological mechanisms of disease

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Petter Brodin

@BrodinPetter

3 years

One virus - Many different disease manifestations - Immune determinants of severe #COVID19 , also #longCOVID and #MISC

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Petter Brodin

@BrodinPetter

4 years

New work from us - Systems Immunology of #MECFS and the targeting of the vagus nerve and inflammatory reflex - an RCT of INMEST showing (~30%) symptom relief

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Petter Brodin

@BrodinPetter

2 years

11yr old girl w persistent intestinal inflammation (pain and f-calprotectin). Biopsy shows SARS-CoV-2 NC protein >3mo post COVID-19. #viralReservoir

Persistent SARS-CoV-2 Nucleocapsid Protein Presence in the... : JPGN Reports

variety of clinical manifestations, including gastrointestinal symptoms. Here, we report a case of persistent abdominal pain, 3 months following a SARS-CoV-2 diagnosis, associated with chronic...

journals.lww.com

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Petter Brodin

@BrodinPetter

4 years

Systems immunology analyses in 39 patients up to 14 samples per patient reveal longitudinal immune cell dynamics from acute to recovery phases of severe #COVID19

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Petter Brodin

@BrodinPetter

3 months

🚨New paper alert! Restrained memory CD8+ T cell responses favors viral persistence and elevated IgG responses in patients with severe #LongCOVID a thread 1/6.

Restrained memory CD8+ T cell responses favors viral persistence and elevated IgG responses in...

During the COVID-19 pandemic it was widely described that certain individuals infected by SARS-CoV-2 experience persistent disease signs and symptoms, Long COVID, which in some cases is very severe...

www.medrxiv.org

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Petter Brodin

@BrodinPetter

3 years

Thanks for a warm welcome! So excited to join @imperialcollege & @ImperialNHS . Much room for us to grow and learn from incredible physician/scientists. Opportunity for pediatric population studies and systems immunology @ImperialPaeCH . Grateful to @WestonFdn for generous support!

Imperial Department of Immunology & Inflammation

@ImperialImmuno

3 years

We're delighted to announce that Professor Petter Brodin ( @BrodinPetter ) has joined us as the Garfield Weston Chair of Neonatology and Professor of Paediatric Immunology. Welcome to the Department & @imperialcollege , Petter!

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Petter Brodin

@BrodinPetter

1 year

What an honor to receive the first ever Olle Söder award! Prof. Söder is a role model physician/scientist and a giant in Swedish academic medicine. Thanks Olle! & thanks to the Pediatric Research Foundation at Astrid Lindgren Children's Hospital

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Petter Brodin

@BrodinPetter

4 years

As physician/scientists our families sacrifice. Long shifts, travels and late night writing take a toll on our loved ones. Today I am celebrating my biggest supporter, fiercest reviewer ( #3 ) and by far wisest advisor. Happy birthday @NyanjaBrodin

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Petter Brodin

@BrodinPetter

2 years

I think this is an unfortunate decision. Vaccines are safe and effective, protect against MIS-C and longCOVID and help kids stay in school etc

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Petter Brodin

@BrodinPetter

5 years

New preprint from us showing that patient self-sampling of capillary blood at home is sufficient for systems-level immunomonitoring. No more venipuncture, no pain, no clinical visits, minimal blood, but tons of data! #Humanimmunology

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Petter Brodin

@BrodinPetter

4 years

New work from our team and collaborators: The Immunology of Multisystem Inflammatory Syndrome in Children with #COVID19 (MIS-C) 1) we contrast MIS-C with Kawasaki disease and mild SARS-CoV2 in kids

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Petter Brodin

@BrodinPetter

3 years

Hej Sven. Jag håller inte med om att infektion alltid ger bättre immunitet än vaccin. CoV-2 viruset hämmar effektivt immunförsvaret (ffa IFN-I) vilket vaccin inte gör. Efter infektion har många skydd mot sjk men ej mot re-infektion. Jag hoppas vaccinen levererar bättre skydd

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Petter Brodin

@BrodinPetter

5 months

Humbled and excited to receive #ERCCoG to study adaptive immune responses to commensals in human newborns

European Research Council (ERC)

@ERC_Research

6 months

📢 Results of the 2023 ERC Consolidator Grant competition are out. €627 million for 308 researchers. Who has been offered funding? What topics and questions will they investigate? Where will they conduct their research? 🇪🇺 @HorizonEU #ERCCoG news 👉

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Petter Brodin

@BrodinPetter

4 years

I am getting lots of Q's internationally about this decision by @karolinskainst to issue a press release for a preprint. I do not agree with it. We must fight #COVID19 with science and if we rush it too much we risk errors that could erode people's trust in science.

Karolinska Institutet

@karolinskainst

4 years

New unpublished results from KI and @KarolinskaUnsju shows that many with mild or asymptomatic #COVID19 show #tcell immunity to the new #coronavirus , even if they don’t have antibodies. This means #Immunity is probably higher than antibody tests suggest.

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Petter Brodin

@BrodinPetter

4 years

New Resource from our team & @ProteinAtlas team out in @sciencemagazine Great @scilifelab collaboration

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Petter Brodin

@BrodinPetter

2 years

Combining clinical work with research…

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Petter Brodin

@BrodinPetter

2 years

#RSV is a real challenge ~100k children dead every year and millions hospitalized. A vaccine is badly needed and important advances have been made @McLellan_Lab and others

RSV Vaccines, Finally Within Reach, Could Prevent Tens of Thousands of Yearly Deaths

This Medical News article discusses how structure-based vaccinology has advanced long-awaited progress on RSV vaccines.

jamanetwork.com

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Petter Brodin

@BrodinPetter

1 year

PROLIFIC trial launch. Phase-2, RCT of 15d #Paxlovid in 400 adults with Severe #LongCovid and objective signs of organ dysfunction/damage following mild/moderate COVID-19. Trial @KarolinskaUnsju - Collab @pfizer @karolinskainst 🧵/

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Petter Brodin

@BrodinPetter

3 years

Sweden w 10M citizens has 21 independent regional health care systems. So far these have failed to test, trace, isolate, protect the elderly and now they are unable to sequence variants. Modern health care is far too complex to be regional, w/wo a pandemic

Svaret efter Tegnells krav: ”Är inte bara att anställa”

Det är regionernas uppgift att själva utföra analyser för att hitta den brittiska mutationen, enligt FHM. Men det är lättare sagt än gjort, menar regionerna – och analyserna dröjer. ”Framför allt...

www.expressen.se

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Petter Brodin

@BrodinPetter

4 years

Bifidobacteria-mediated immune system imprinting early in life

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Petter Brodin

@BrodinPetter

4 months

A discussion on recent advances in our understanding of immune perturbations in long COVID and work by @VirusesImmunity and colleagues. With @LucieSTRod

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Petter Brodin

@BrodinPetter

3 years

#covid19 #MISC A key to unravel viral and genetic causes of Kawasaki disease - Another team effort! @SanchoShimizu @ShenYingZhang1 @casanova_lab and many more

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Petter Brodin

@BrodinPetter

1 month

Honored to join the best scientists in Sweden as a Wallenberg Scholar. Thanks @KAWstiftelsen for the recognition and your invaluable support.

KAW

@KAWstiftelsen

1 month

18 of Sweden's top researchers are granted SEK 2.1 billion “We hope this enables daring and groundbreaking #research ," says Peter Wallenberg Jr," Chair of Knut and Alice Wallenberg Foundation #KAW100 #science See the list of Wallenberg Scholars 2024

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Petter Brodin

@BrodinPetter

6 months

This needs to be carefully monitored - respiratory illness affecting children predominantly and spreading fast in 🇨🇳 with hospitals filling up:

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Petter Brodin

@BrodinPetter

4 years

New work from our team - "Human immune system variation during one year". Healthy, middle-aged individuals #Immunology #SystemsImmunology #CyTOF

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Petter Brodin

@BrodinPetter

4 years

We are looking for Postdoc Molecular biologist(s) to work on human immune development early in life - please spread the word! ⁦ @scilifelab ⁩ ⁦ @karolinskainst ⁩ #SystemsImmunology

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Petter Brodin

@BrodinPetter

2 years

I am grateful and honoured to receive an AMS professorship @acmedsci Thanks to my lab members & @imperialcollege

Professorship scheme awardees

acmedsci.ac.uk

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Petter Brodin

@BrodinPetter

5 years

A call for blood in Human immunology @QuintanaMurci @darragh_duffy PBMC prep is a major source of variation. With preserved Whole blood we separate patients better, and learn more #HumanImmunology #SystemsImmunology @ImmunityCP @scilifelab @karolinskainst

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Petter Brodin

@BrodinPetter

3 years

Understanding #LongCovid through genomics, immunology and virology @metricausa @naturemethods for highlighting our ongoing work

Scientists set out to connect the dots on long COVID

Nature Methods - With grit, urgency and creativity, scientists address the puzzle of long-haul COVID.

www.nature.com

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Petter Brodin

@BrodinPetter

2 years

We are looking for #postdoctoral immunologist to join our efforts studying immune-microbe interactions early in life. Please DM me if interested!

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Petter Brodin

@BrodinPetter

1 year

Exaggerated responses to a virus long gone

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Petter Brodin

@BrodinPetter

2 years

Fabulous! intranasal Spike boost for mucosal protection. So elegant and important! well done!

Prof. Akiko Iwasaki

@VirusesImmunity

2 years

Vaccines that reduce infection & disease are needed to combat the pandemic. Here, @tianyangmao @BenIsraelow et al. describe our new mucosal booster strategy, Prime and Spike, to induce such immunity via nasal delivery of unadjuvanted spike vaccine 🧵 (1/)

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Petter Brodin

@BrodinPetter

3 years

Really difficult fall ahead in Swedish health care. #RSV on the rise (below), many kids born 2019-21 not immune. Also kids below <16yrs unvaccinated against #COVID19 and #DeltaVariant dominating. Winter is coming…

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Petter Brodin

@BrodinPetter

3 years

99% fullt på IVA o riktigt jobbigt i vården nu. Detta mot bakgrund av nedskärningar, försämringar o personalflykt i decennier. "Normal" beläggningsgrad är ~108% i Sthlm. Gå nu ifrån 21 -> 1 sjukvårdssystem. Rädda det som räddas kan Låt professionerna leda, återuppliva forskningen

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Petter Brodin

@BrodinPetter

2 years

⁦ @barnlakaren ⁩ och FHM - 5M barn mellan 5-11år #COVID19 vaccinerade bara i USA. Vad väntar ni på?! vilka data saknas? skyddet gott o riskerna små. Erbjud vaccin till alla som vill nu!

Beslut om covidvaccin till yngre barn splittrar experter

Både Folkhälsomyndigheten och Barnläkarföreningen brottas nu med frågan om ännu yngre barn bör vaccinera sig mot covid-19 – eller inte.

www.dn.se

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Petter Brodin

@BrodinPetter

3 years

Jag håller inte heller med om att sjukdomen alltid är mild hos barn. >80 familjer med barn drabbade av livshotande MIS-C skulle troligen säga emot dig. Vi vaccinerar barn mot mässling för att undvika encefalit hos 1/10.000. MIS-C är lika allvarligt o ungefär lika frekvent

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Petter Brodin

@BrodinPetter

2 years

Brilliant special issue @ScienceMagazine . I discuss the establishment of immune-microbe interactions early in life and its importance for long-term health, Brief 🧵:

A multiplicity of microbiomes

www.science.org

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Petter Brodin

@BrodinPetter

4 months

Persistent complement dysregulation with signs of thromboinflammation in active #LongCovid :

Persistent complement dysregulation with signs of thromboinflammation in active Long Covid

Analysis of blood revealed that Long COVID is characterized by changes to complement proteins and platelet activation.

www.science.org

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Petter Brodin

@BrodinPetter

4 years

honored to be elected into such a stellar group of young scientists! Thanks @EMBO and my fantastic group @scilifelab @karolinskainst

EMBO

@EMBO

4 years

We're excited to announce that 27 life scientists have been selected as this year's EMBO Young Investigators @EMBO_YIP . Congratulations! More information:

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Petter Brodin

@BrodinPetter

6 years

New from us: Stereotypic Immune System Development in Newborn Children.

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Petter Brodin

@BrodinPetter

1 year

We need to convince more young people to pursue a physician/scientist career! inspiration from A. Fauci: A Message to the Next Gen Scientists

Opinion | Anthony Fauci: A Message to the Next Generation of Scientists (Published 2022)

As he prepares to retire, “America’s doctor” discusses his work developing AIDS treatments and helping the nation navigate the coronavirus pandemic.

www.nytimes.com

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Petter Brodin

@BrodinPetter

7 months

Exciting new study from Bali Pulendran lab @stanfordimmuno on immune responses to SARS-CoV-2 in young children: @CellCellPress - Does the persistent plasmablast response indicate persistent antigens in children?

Multi-omics analysis of mucosal and systemic immunity to SARS-CoV-2 after birth

Multi-omics analysis of blood and nasal samples from human infants and their mothers indicates strong and sustained immunity following SARS-CoV-2 infection during the initial months of life.

www.cell.com

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Petter Brodin

@BrodinPetter

3 years

Beautiful study on the importance of iron for T-cell responses. Enormous implications for susceptibility to infection, vaccination and overall global health! ⁦congrats @Drakesmith_Lab ⁩

Hepcidin-Mediated Hypoferremia Disrupts Immune Responses to Vaccination and Infection

Iron deficiency is very common in humans and animals. Frost et al. demonstrate that low concentrations of iron in serum, caused by the hormone hepcidin, inhibit the body’s response to vaccines and...

www.cell.com

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Petter Brodin

@BrodinPetter

1 year

🙏🏼 @wellcometrust Discovery Award for us to study microbial metabolites as immunomodulators @imperialcollege @ImperialPaeCH @ImperialImmuno

Microbial metabolites in human newborns – future immunomodulatory agents for young and old | Grants...

Wellcome-funded research through our Discovery Awards

wellcome.org

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Petter Brodin

@BrodinPetter

3 years

1 year ago today China sent out the alert of an Undiagnosed pneumonia in Hubei province @ProMED_mail - what a year it has been since then...

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Petter Brodin

@BrodinPetter

4 years

Science matters and Germany has a scientist as Commander-in-chief #COVID19

Benjamin Alvarez

@BenjAlvarez1

4 years

This is how Angela Merkel explained the effect of a higher #covid19 infection rate on the country's health system. This part of today's press conf was great, so I just added English subtitels for all non-German speakers. #flattenthecurve

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Petter Brodin

@BrodinPetter

2 years

#Covid19 Vaccine (Pfizer) prevents #MISC in 🇺🇸 Children

Effectiveness of BNT162b2 (Pfizer-BioNTech) ...

This report describes how effective Pfizer-BioNTech COVID-19 vaccination was against multisystem inflammatory syndrome in children (MIS-C).

www.cdc.gov

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Petter Brodin

@BrodinPetter

2 years

Science and medicine really came through in 2021. I am so proud of belonging to a community of hard-working, dedicated individuals, collaborating across the globe. Happy new year! and to those on service now, thanks to you and your loved ones #COVID19 #Science #immunology #Peds

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Petter Brodin

@BrodinPetter

4 years

Human Immune System Variation during 1 Year - large team effort at @scilifelab - CyTOF data by @LkanthTadepally and plasma proteins by @OlinkProteomics - computational analyses by Sayyed Auwn Muhammad and more #ImmuneSystem #variation

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Petter Brodin

@BrodinPetter

2 years

beautiful study and very important for understanding post-infectious brain disorders @VirusesImmunity @michelle_monje and teams #pacs #LongCovid #MISC

Michelle Monje🎗️

@michelle_monje

2 years

The final version of our study seeking to understand how even mild respiratory COVID can affect the brain is now published. Sharing an updated thread… 1/ Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation

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Petter Brodin

@BrodinPetter

3 years

Data and science lead the way out of the #COVID19 pandemic. We can disagree on policies and interpret data differently but we cannot accept attacks and threats to those that bring data out in the open

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Petter Brodin

@BrodinPetter

3 years

SARS-CoV-2 Antigens in the Gut and Blood of children w #MISC

SARS-CoV-2 Antigens Leaking from Gut to Blood Might Trigger MIS-C

Researchers find traces of SARS-CoV-2 in the stool and blood of kids with the post-COVID-19 inflammatory disorder, and signs of increased intestinal permeability.

www.the-scientist.com

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Petter Brodin

@BrodinPetter

5 years

First in humans - Antibiotic treatment increases inflammation and hampers vaccine responses. Great paper by Bali Pulendran and colleagues!

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Petter Brodin

@BrodinPetter

3 years

Oxford-AZ vaccine study in kids 6-17 years. I’d recommend repeated PCR-testing to see protection from infection and not only disease which is rare in children. Protection from infection will probably prevent #MISC and #LongCovid and reduce transmission

Covid: Oxford-AstraZeneca vaccine to be tested on children

A trial will assess whether the vaccine produces a strong immune response in six to 17-year-olds.

www.bbc.com

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Petter Brodin

@BrodinPetter

5 years

New from us in @NatureMedicine Using VirScan to profile the repertoire of maternal IgG against 93,904 epitopes from 1276 viral strains in human newborns. 1) We map immundominant epitopes targeted for each virus... #newborn #immunity

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Petter Brodin

@BrodinPetter

2 years

Great preprint showing SARS-CoV-2 infection and persistence throughout the human body and brain even in patients who died following mild COVID-19. important findings for #MISC #LongCOVID

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Petter Brodin

@BrodinPetter

3 years

Just like the US closing its border to China when the virus was already circulating in the states, EU countries are now closing its border with the UK. The new CoV-2 variant is already widespread and these decisions are political-not scientifically motivated

Kai Kupferschmidt

@kakape

3 years

I understand the idea to some extent, but this may quickly become untenable as virus carrying this mutation is picked up in other countries. The UK has arguably the world’s best genomic surveillance of #SARSCoV2 . You would expect to find it there first even if it is many places.

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Petter Brodin

@BrodinPetter

3 years

True. As a pediatrician and parent I am particularly grateful for the way that children and their overall wellbeing have been considered throughout the #covid19 pandemic in Sweden

Alasdair Munro

@apsmunro

3 years

There have been many criticisms of Sweden’s approach to the pandemic, but one thing you can’t accuse it of is being unpopular with its own people

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Petter Brodin

@BrodinPetter

2 years

Viral persistence in MIS-C is now well established, but why mostly in children and preceded by mild COVID-19? Fits w disease tolerance model as described here:

Jan Choutka

@jan_choutka

2 years

This is an autopsy of 5yo child who died of MIS-C 1 month after infection. SARS-CoV-2 was found in multiple organs by electron microscopy, PCR, or staining. They also found aspergillosis and reactivated CMV, both attributed to immunosuppressive treatment.

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Petter Brodin

@BrodinPetter

9 months

Scientists of Twitter! The world needs more reminders that we're living, breathing human beings. Quote tweet this with a picture of you doing not-science. Science is my day job 😉...but "Music Is My Sanctuary" as Gary Bartz sings

Lluis Quintana-Murci

@QuintanaMurci

9 months

Scientists of Twitter! The world needs more reminders that we're living, breathing human beings. Quote tweet this with a picture of you doing not-science. (Me in my most natural ecosystem: the sea and Mallorca)

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Petter Brodin

@BrodinPetter

2 years

Evidence of sustained inflammation >8mo in #LongCOVID

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Petter Brodin

@BrodinPetter

4 years

The network delivers two important papers explaining ~14% of severe #COVID19 in previously healthy individuals. 1) Autoantibodies to IFN-I and inborn errors of TLR3/7 or IFN-signaling. I am so grateful to participate in this effort

COVID HUMAN GENETIC EFFORT

COVID Human Genetic Effort is an international consortium aiming to discover inborn errors of immunity underlying severe forms of COVID-19 in previously healthy individuals

www.covidhge.com

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Petter Brodin

@BrodinPetter

4 years

I am aware of this! My team and I are writing up a systems-immunology analysis of ME/CFS. It should be coming out very soon. Stay tuned!

ME/CFS News

@MECFSNews

4 years

@BrodinPetter we patients with chronic fatigue syndrome need research to identify the blood factors that are affecting cell function in this illness. There is now a strong suspicion that such factors exist.

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Petter Brodin

@BrodinPetter

2 years

Chris Goodnow is a remarkable scientists and immunologist - This is his personal account of developing COVID-associated myocarditis

Three myths about COVID-19 — and the biggest challenge that lies ahead

With four decades of research on antibodies under my belt, I always felt like I had a pretty good handle on COVID-19. But when I caught the virus in May, my hubris quickly turned into humility,...

www.abc.net.au

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Petter Brodin

@BrodinPetter

2 years

Wow! this must be one of the best immunology departments in the world. Do apply!

Prof. Akiko Iwasaki

@VirusesImmunity

2 years

Seeking candidates for TWO tenure-track assistant/associate positions for @YaleIBIO : one for Section of Human & Translational Immunology and the other one for general immunology. We welcome applicants from diverse backgrounds. Please apply & RT 😊

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Petter Brodin

@BrodinPetter

3 years

Thrilled to recieve support for immunological analyses of adverse reactions to #COVID19 vaccines

The KAW-supported SciLifeLab program on COVID-19 vaccine effects is now launched with ten projects

In December 2020, SciLifeLab and the Knut and Alice Wallenberg Foundation (KAW), announced a call for a national program studying the effects of COVID-19 vaccines. 24 proposals were submitted and […]

www.scilifelab.se

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Petter Brodin

@BrodinPetter

4 years

Only 730 proteins actively secreted into the blood, many more detectable as leakage products. The Human Secretome @HumanProteome @scilifelab

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Petter Brodin

@BrodinPetter

5 months

Amazing to be at #IUIS2023 in beautiful Cape Town and share our recent results on the Immunomodulatory effects of Testosterone in humans. Incredible meeting thus far!

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Petter Brodin

@BrodinPetter

2 years

4/ In COVID19, kids have been shown to have more efficient local antiviral responses in the airways, but there is also evidence for slower viral clearance in stool from children vs adults. Could a milder systemic immune response lead to viral persistence in the gut of children?

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Petter Brodin

@BrodinPetter

5 years

Human Immune variation with age. Systems-level patterns emerge @NatRevImmunol

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Petter Brodin

@BrodinPetter

1 year

@noren_elisabeth @TomHedrup @AgnesWold Detta är felaktigt. Visserligen stimuleras minnesceller av varje infektion men varje infektion är en risk för nya virusreservoarer, autoimmuna konsekvenser och kärlkomplikationer som ligger i andra vågskålen…

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Petter Brodin

@BrodinPetter

10 months

Excellent review by Clare @lloyd_lab & @sejalsaglani @ImperialNHLI @ImperialPaeCH on early life interactions btw a developing immune system, colonizing microbes and protective/damaging environmental factors with longterm consequences for lung health:

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Petter Brodin

@BrodinPetter

4 years

Cytokinstorm - Därför kan unga och friska bli rejält sjuka av corona via @svtnyheter

Därför kan unga och friska bli svårt sjuka av coronaviruset

Immunförsvaret kan överreagera mot det nya coronaviruset och skapa cytokinstormar i kroppen, som angriper inre organ. Det finns redan befintliga mediciner som hjälper mot detta.

www.svt.se

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Petter Brodin

@BrodinPetter

3 years

Severe #COVID19 in a child with APS1 and interferon autoantibodies successfully treated with plasmapheresis @sahlgrenska

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Petter Brodin

@BrodinPetter

2 years

Enl CDC, 211 barn 5-11år dött av #COVID19 i USA. Inga dödsfall direkt kopplade till vaccin. BLFs @barnlakaren Per Brolin menar att infektion kanske är bättre för barnen än vaccination?! så sorgligt ovetenskapligt

”Omikron påverkar beslutet” - LäkemedelsVärlden

Omikron kan ha betydelse för Folkhälsomyndigheteten beslut om en eventuell vaccinering av yngre barn, enligt barnläkarföreningens Per Brolin.

www.lakemedelsvarlden.se

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Petter Brodin

@BrodinPetter

1 year

Contrasting Human/Mouse immunological phenotypes vs genotypes offers a way forward: @casanova_lab

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Petter Brodin

@BrodinPetter

3 years

Launch of a new speciality section of @FrontImmunol on Systems Immunology. Thanks to all fellow editors

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Petter Brodin

@BrodinPetter

2 years

National Swedish follow-up study in kids w MIS-C show good recovery for most. Heart involvement mostly transient but some, mostly neurological, persistent symptoms

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Petter Brodin

@BrodinPetter

5 years

Honored to be one of eight newly elected members in the Young Academy of Sweden @Ungaakademin @karolinskainst @scilifelab

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Petter Brodin

@BrodinPetter

1 year

My perspective on #MISC inspired by recent breakthrough by @casanova_lab et al & expanded Vb21.3 T cells. Is the delay caused by tissue resident cells act by a persistent virus?

Exaggerated responses to a virus long gone

Multisystem inflammatory syndrome in children is caused by abnormal cell activation

www.science.org

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Petter Brodin

@BrodinPetter

2 years

Thanks Eric!

Eric Topol

@EricTopol

2 years

A solid hypothesis for the basis of the mysterious, severe acute hepatitis in children: superantigen formation from prior Covid viral reservoir in the GI tract with superimposed adenovirus infection @LancetGastroHep

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Petter Brodin

@BrodinPetter

4 years

Diskuterar #COVID19 och immunförsvar hos unga patienter @malou_vonsivers

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