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Nature Medicine

13 days

⚡Our April issue is live! Featuring studies on #cancer #vaccines & #neoadjuvant therapy, clinical #AI , an #AlzheimersDisease blood test, telehealth #abortion , #ParkinsonsDisease , #T2D , and much more including news, reviews & opinion.

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Nature Medicine

@NatureMedicine

4 years

"Our analyses clearly show that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus." -> read now: #covid19 @K_G_Andersen

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4 years

Children infected with the #COVID19 outbreak coronavirus, SARS-CoV-2, show mild symptoms but prolonged shedding of viral RNA in feces, suggesting that the fecal–oral route might play a role in virus transmission #CORONAVIRUS

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4 years

New results indicate that surgical face masks could prevent transmission of human #coronavirus (and #flu ) from symptomatic individuals - Read now: @bencowling88 @HKUniversity #COVID19

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3 years

A longitudinal analysis of humoral immune responses in patients with #COVID19 with varying disease severity reveals that mortality does not correlate with antiviral antibody levels but, instead, with slower seroconversion. #immunology @VirusesImmunity

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5 months

Academic clinician–scientists risk becoming an endangered species. World View from @StephenORahilly @Cambridge_Uni

Academic clinician–scientists risk becoming an endangered species

Nature Medicine - Barriers to their training and retention threaten medical research

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2 years

Humanitarian aid must be allowed to enter the besieged Tigray region of Ethiopia. Correspondence from Wasan M. Kumar, Bereket A. Gebregziabher, Reiye E. Mengesha and Paul Wise @Stanford

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5 years

AI technology has made new progress in detecting different types of brain trauma:

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5 years

Disruption of the #circadianclock has been linked to #cancer and alterations in cancer #metabolism and this has implications for therapeutic development:

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5 years

Researchers at @GoogleAI have designed an #ArtificialIntelligence -powered microscope able to detect tumor cells in histology slides that could accelerate #pathology workflows for #cancer diagnosis―Read full paper 👉 #digitalmedicine #Biotechnology #AI

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11 months

A single-cell analysis of tumor-infiltrating T cells from 16 cancer types identifies new T cell subsets and a stress response cell state enriched in tumors resistant to immunotherapy.

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1 month

⚡ Our March issue is live! Featuring several #biomarker and #immunotherapy studies in #CRC , #PancreaticCancer , #HCC and others, studies on #tuberculosis , #cholera , #postnataldepression , foundation #AI , as well as News, Reviews, Opinion and more...

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3 months

Surge in endometriosis research after decades of underfunding could herald new era for women’s health. News feature by @clarewhatson , as part of our Series on Women's Health

Surge in endometriosis research after decades of underfunding could herald new era for women’s...

Nature Medicine - Advances in organoids and the role of the microbiome and diet are leading to new diagnostics and treatments for endometriosis, motivating a precision health approach to this...

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2 years

To celebrate #BlackHistoryMonth , we're highlighting pieces by and about fantastic Black researchers in the United States. First up: @FutureDrDukes , the founder of @BlackInNeuro , shares ways you can better support Black trainees in the biomedical sciences

How to better support Black trainees in the biomedical sciences

Nature Medicine - The relentless violence against Black people takes an overwhelming emotional toll on Black trainees. In those we continue to lose, we see our families, our friends and our own...

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6 years

The muscle-secreted, exercise-induced peptide hormone apelin decreases with #aging and sarcopenia, and its repletion in aged mice with recombinant protein improves muscle mass and function:

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4 years

Nature Medicine summarizes all the research you need to know this week on the #COVID19 pandemic. This week, read about the convalescent plasma transfusion study showing promise for treating critically ill patients with #coronavirus disease 2019

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4 years

Despite elevated brain #amyloid pathology, a unique human case harboring a rare mutation in #APOE is reported by @ytquiroz and colleagues to be resistant to inherited #Alzheimer ’s disease |

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2 years

Humanitarian aid must be allowed to enter the besieged Tigray region of Ethiopia. Correspondence from Wasan M. Kumar, Bereket A. Gebregziabher, Reiye E. Mengesha and Paul Wise @Stanford

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5 years

Initial results from a first-in-human study show that PET imaging with PD-L1 antibodies outperforms immunohistochemistry- or RNA-sequencing-based biomarkers for prediction of clinical response to #immunotherapy :

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5 years

Researchers at @GoogleAI report an #AI framework able to predict malignancy risk of lung nodules on CT scans that might improve early lung #cancer detection | | #ArtificialIntelligence #deeplearning

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4 years

Breadth of concomitant immune responses prior to patient recovery: a case report of a non-severe #COVID19 @unimelb @TheDohertyInst @ProfSharonLewin #COVID ー19 #COVID19Aus

Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe...

Nature Medicine - Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19

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11 months

A single-cell analysis of tumor-infiltrating T cells from 16 cancer types identifies new T cell subsets and a stress response cell state enriched in tumors resistant to immunotherapy.

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3 months

⚡ Our January 2024 issue is live! Featuring new studies on #FallPrevention #SecondHandSmoke #Antibiotics #KRAS #100KGenomesCancer and much more - including News, World Views and our new series on Women's Health!

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8 months

Analyses of 1,277 human brain proteomes reveal the extent of sex differences in the brain and identify genes associated with neuropsychiatric diseases that have differential regulation between males and females @wingolab @EmoryMedicine

Sex differences in brain protein expression and disease

Nature Medicine - Analyses of 1,277 human brain proteomes reveal the extent of sex differences in the brain and identify genes associated with neuropsychiatric traits that have differential...

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4 years

The race for coronavirus vaccines: a graphical guide

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2 years

Humanitarian aid must be allowed to enter the besieged Tigray region of Ethiopia. Correspondence from Wasan M. Kumar, Bereket A. Gebregziabher, Reiye E. Mengesha and Paul Wise @Stanford

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4 months

A single-cell spatial transcriptomic and proteomic study of #immune cells in the human #CNS border compartments reveals differences in CNS-associated macrophages across age, perturbation and disease. @r_sankowski #macrophages #microglia

Multiomic spatial landscape of innate immune cells at human central nervous system borders

Nature Medicine - A single-cell spatial transcriptomic and proteomic study of immune cells in the human CNS border compartments reveals differences in CNS-associated macrophages across age,...

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4 years

Nature Medicine summarizes all the research you need to know this week to keep on top of how science is responding to the #COVID19 pandemic. #coronavirus

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1 year

11 trailblazing early-career researchers, shaping the future of #medicine , share what they are most excited about right now and where their research is going in the next 5 years - read now:

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3 years

Injection of a light-activated #genetherapy vector combined with the wearing of light-stimulating goggles achieves partial vision restoration in a blind patient with retinitis pigmentosa. #optogenetics #RareDisease @IOB_Roska @InstVisionParis

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3 years

Single-cell #transcriptomics and #proteomics profiling of #COVID19 samples reveals immune and HSPC changes that are differentially associated with disease severity @HaniffaLab @ClatworthyLab @MarioniLab @UniofNewcastle @sangerinstitute @humancellatlas

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4 months

Autoimmune disease is the next frontier for CAR T cell therapy. News feature by @edbites

Autoimmune disease is the next frontier for CAR T cell therapy

Nature Medicine - CAR T cell therapy has transformed the treatment of B cell cancers and is now being pursued by biotech companies for conditions as varied as systemic lupus erythematosus, diabetes...

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3 years

Results from a phase 3 randomized clinical trial demonstrate that MDMA-assisted therapy is safe and effective for treating patients with severe post-traumatic stress disorder. #PTSD @UCSF

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5 years

First clinical use of engineered bacteriophages for the treatment of disseminated mycobacterial infection | @GHatfull @DrHelenSpencer

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1 year

For #InternationalWomensDay - we have a correspondence discussing women's rights in Iran in the face of oppression

Protecting public health in Iran in the face of oppression

Nature Medicine - Discover the world’s best science and medicine | Nature.com

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3 months

Autoimmune disease is the next frontier for CAR T cell therapy. News feature by @edbites

Autoimmune disease is the next frontier for CAR T cell therapy

Nature Medicine - CAR T cell therapy has transformed the treatment of B cell cancers and is now being pursued by biotech companies for conditions as varied as systemic lupus erythematosus, diabetes...

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4 years

In recovered #COVID19 patients, virus spike-specific #antibodies were consistently elicited, but neutralizing activity was variable and inversely correlated with the proportion of CCR6+CXCR3- spike-specific circulating T follicular helper cells. @unimelb

Humoral and circulating follicular helper T cell responses in recovered patients with COVID-19

Nature Medicine - In a cohort of recovered patients with COVID-19, virus spike-specific antibodies were consistently elicited, but neutralizing activity was highly variable and inversely correlated...

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5 months

11 clinical trials that will shape medicine in 2024 - from base editing and a vaccine against HIV to AI tools for lung cancer and patient triage. Part of our Year in Review, by Paul Webster and @edbites

11 clinical trials that will shape medicine in 2024

Nature Medicine - Nature Medicine asks leading researchers to name their top clinical trial for 2024, from base editing and a vaccine against HIV to artificial intelligence tools for lung cancer...

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2 years

SARS-CoV-2 is not unique in its ability to cause long-term sequelae. In our latest Review: Akiko Iwasaki, Jan Choutka & colleagues discuss what we know (& don't know) about unexplained post-acute infection syndromes @jan_choutka @VirusesImmunity @YaleMed

Unexplained post-acute infection syndromes

Nature Medicine - Certain acute infections (including SARS-CoV-2) are associated with an unexplained chronic disability in a minority of patients; this Review summarizes what is known about these...

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4 months

A single-cell spatial transcriptomic and proteomic study of #immune cells in the human #CNS border compartments reveals differences in CNS-associated macrophages across age, perturbation and disease. @r_sankowski #macrophages #microglia

Multiomic spatial landscape of innate immune cells at human central nervous system borders

Nature Medicine - A single-cell spatial transcriptomic and proteomic study of immune cells in the human CNS border compartments reveals differences in CNS-associated macrophages across age,...

www.nature.com

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@NatureMedicine

6 years

A full night of sleep deprivation causes attenuated & delayed neuronal responses that correlate w/impaired cognition

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4 years

A cross-sectional study of hospitalized patients with #COVID19 and a longitudinal follow-up study of patients with #COVID_19 suggest that #SARS_COV_2 -specific IgG or IgM seroconversion occurs within 20 days post symptom onset. #AntibodyTesting #Antibody .

Antibody responses to SARS-CoV-2 in patients with COVID-19

Nature Medicine - A cross-sectional study of hospitalized patients with COVID-19 and a longitudinal follow-up study of patients with COVID-19 suggest that SARS-CoV2-specific IgG or IgM...

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3 years

Has SARS-CoV-2 reached peak fitness? Correspondence from @RobertoBurioni and @EricTopol

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6 months

Boosting #CARTcells with anti-tumor #mRNAvaccines led to robust anti-neoplastic activity in patients with genitourinary cancers, paving the way for a promising new treatment strategy. News and Views from @montypal & colleagues @cityofhope #ESMO2023

Boosting CAR T cells with anti-tumor mRNA vaccines

Nature Medicine - A new approach that combines CAR T cells with serial mRNA vaccine injections facilitates robust anti-neoplastic activity in patients with genitourinary cancers, which will pave...

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3 years

Flaws in ivermectin data suggest that COVID-19 meta-analyses need rethinking Correspondence from Jack Lawrence @GidMK @K_Sheldrick and colleagues

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1 year

Organ-specific #aging clocks for multiple #brain and body systems show that the #biologicalage of one organ system selectively influences the aging of multiple other systems via specific aging pathways @yetianmed @AndrewZalesky @UniMelb @UniMelbMDHS

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2 years

A high-throughput platform to find rare #Tcells that recognize shared cancer #neoantigens identifies TCRs specific for a conserved and therapeutically actionable epitope in mutant PIK3CA, a common driver oncogene @KlebanoffLab @MSKCancerCenter @parkerici

Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA

Nature Medicine - A new high-throughput platform to find rare T cells that can recognize shared cancer neoantigens identifies T cell receptors specific for a conserved, immunogenic and...

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1 year

⚡️Our April issue is out!⚡️With two papers from the TRACERx #LungCancer study, clinical trials in #Diabetes and #ProstateCancer , studies on salt substitution for lowering #BloodPressure and on #AI for #BrainCancer diagnosis, news, opinions, and much more!

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5 years

Researchers @ThomasFuchsAI and colleagues @sloan_kettering report a deep learning framework for real-world digital pathology data that achieves clinical performance for #cancer diagnosis | #artificialintelligence

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6 months

Out today for #ESMO23 : In a large multi-cancer cohort, a single liquid biopsy assay enables the detection of four epigenomic modifications, allowing the monitoring of expression of potential drug targets and resistance genes @SylvanBacaLab @DrChoueiri

Liquid biopsy epigenomic profiling for cancer subtyping

Nature Medicine - In a large multi-cancer cohort, a single liquid biopsy assay enables the detection of four epigenomic modifications, allowing the monitoring of expression of potential drug...

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2 months

Today, together with @NEJM_AI , we present a statement from the RAISE Consortium mapping immediate actions for healthcare leaders to support the responsible and ethical transition of healthcare to an AI-powered future. Read it now: @HarvardDBMI @zakkohane

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4 years

A new study estimates that the overall symptomatic case fatality risk - the probability of dying after developing symptoms of #COVID19 in Wuhan - was about 1.4%. Read now at @gmleunghku @mlipsitch @HKUniversity #SARSCoV2

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7 years

Advancements in MRI are giving us an unprecedented look at the fetal brain. Read more in our feature story:

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3 years

First-generation students, whose parents do not have degrees, are under-represented on MD-PhD programmes and need better support, argue @BriChristophers and colleagues at @TriIMDPhD #firstgen

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5 years

Scientists have succeeded in fixing a DNA error responsible for #cysticfibrosis in a mouse model of the disease:

In-utero edit in mice fixes cystic fibrosis gene

Nature Medicine - Nanoparticles repaired the mutated Cftr gene -- which drives the life-threatening disorder

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2 years

An mRNA #vaccine platform to prevent HIV-1 infection generated broadly neutralizing antibodies in nonhuman primates and protected some animals from infection, raising hope that optimization of this approach might lead to an effective #HIV vaccine @NIAIDNews

A multiclade env–gag VLP mRNA vaccine elicits tier-2 HIV-1-neutralizing antibodies and reduces the...

Nature Medicine - An mRNA vaccine platform to prevent HIV-1 infection generated broadly neutralizing antibodies in non-human primates and protected some animals from infection, raising hope that...

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5 years

Rotten eggs get their awful stink from hydrogen sulfide. But there might be an upside to this gas: in a new mouse study, it prevented clogged arteries:

Smelly gas protects against clogged arteries

Nature Medicine - Mice given a hydrogen-sulfide-generating drug had less plaque buildup

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4 years

Nature Medicine summarizes all the research you need to know this week on the #COVID19 pandemic. This week, read about the epidemiological analysis of 72 hospitals in Lombardy, Italy, where the ICU mortality rates were 26%. Free now, online. #Coronavirus

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1 year

A large, publicly available dataset integrating RNA, whole-exome, T cell receptor and 16S rRNA sequencing from patients with #ColonCancer enables the discovery of a #PrognosticScore consisting of tumor, immune and microbial features. #Microbiome #Tcell

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4 years

A cohort of asymptomatic patients infected with #SARSCoV2 had significantly lower levels of virus-specific IgG antibodies compared to a cohort of age- and sex-matched symptomatic infected patients. #COVID19 #asymptomatic #coronavirus #CQMU

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4 years

A #MachineLearning algorithm based on an array of demographic, physiological and clinical information is able to predict, hours in advance, circulatory failure of patients in the intensive-care unit @kmborgwardt @ETH_en @gxr @_hylandSL #NMEDClinical

Early prediction of circulatory failure in the intensive care unit using machine learning

Nature Medicine - A machine-learning algorithm based on an array of demographic, physiological and clinical information is able to predict, hours in advance, circulatory failure of patients in the...

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4 years

On March 4, #WorldObesityDay , we at Nature Medicine and all journals @nresearchnews pledge to work together to help ending the #stigma of #obesity > #openaccess @WorldObesity @FRubinoMD @KingsCollegeLon

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3 years

Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells , but therapeutic benefit can be improved by combining with liver-directed #radiotherapy #metastasis #macrophages @UMichSurgery @umichmedicine

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5 years

Nature Medicine is turning 25 this year! To kick off our 25th year, we've put together a focus issue on Digital Medicine. Check out the table of contents here:

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4 years

A cross-sectional study of hospitalized patients with #COVID19 and a longitudinal follow-up study of patients with #COVID_19 suggest that #SARS_COV_2 -specific IgG or IgM seroconversion occurs within 20 days post symptom onset. #AntibodyTesting #Antibody .

Antibody responses to SARS-CoV-2 in patients with COVID-19

Nature Medicine - A cross-sectional study of hospitalized patients with COVID-19 and a longitudinal follow-up study of patients with COVID-19 suggest that SARS-CoV2-specific IgG or IgM...

www.nature.com

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4 years

Hi, I'm Joao Monteiro, chief editor @NatureMedicine and I'll be taking over the journal's account this week - follow me using the hashtag #NMEDtwittertakeover

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4 years

A randomized trial in Peru demonstrates population-wide reductions in blood pressure and risk of developing #hypertension after replacement of regular salt with a potassium-enriched alternative #NMEDClinical @jjaimemiranda @cronicasperu @CayetanoHeredia

Effect of salt substitution on community-wide blood pressure and hypertension incidence

Nature Medicine - A step-wedged cluster randomized trial, carried out in six villages in Tumbes, Peru, with 2,376 participants, demonstrates population-wide reductions in blood pressure, which...

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11 months

A #single -cell atlas of the human #lungs , integrating data from 2.4 million cells from 486 individuals and including samples from healthy and diseased lungs, provides a roadmap for generating organ-scale cell atlases. @SikkemaLisa @MDLuecken @fabian_theis

An integrated cell atlas of the lung in health and disease

Nature Medicine - A single-cell atlas of the human lungs, integrating data from 2.4 million cells from 486 individuals and including samples from healthy and diseased lungs, provides a...

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8 months

A #machinelearning classifier predicts origin of cancer of unknown primary based on #electronicrecords and #NGS data, showing that patients treated accordingly to model predictions had significantly better outcomes. @DanaFarber @broadinstitute

Machine learning for genetics-based classification and treatment response prediction in cancer of...

Nature Medicine - A machine-learning classifier predicts the origin of cancer of unknown primary based on electronic health records and next-generation sequencing data, showing that patients...

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3 months

⭐Research highlight: Patients who received an in vivo #CRISPR based gene-editing therapy for hereditary angioedema showed no serious side effects and nearly complete disease control. @NEJM

Gene-editing breakthrough for a rare hereditary disorder

Nature Medicine - Patients who received an in vivo CRISPR-based gene-editing therapy for hereditary angioedema showed no serious side effects and nearly complete disease control.

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5 months

11 clinical trials that will shape medicine in 2024 - from base editing and a vaccine against HIV to AI tools for lung cancer and patient triage. Part of our Year in Review, by Paul Webster and @edbites

11 clinical trials that will shape medicine in 2024

Nature Medicine - Nature Medicine asks leading researchers to name their top clinical trial for 2024, from base editing and a vaccine against HIV to artificial intelligence tools for lung cancer...

www.nature.com

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2 months

#Endometriosis takes 7-10 years to diagnose, on average; but a surge in research is finally leading to new diagnostics and treatments. News feature from @clarewhatson #InternationalWomensDay2024

Surge in endometriosis research after decades of underfunding could herald new era for women’s...

Nature Medicine - Advances in organoids and the role of the microbiome and diet are leading to new diagnostics and treatments for endometriosis, motivating a precision health approach to this...

www.nature.com

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10 months

A risk score developed using biological, psychological, and social factor data from the @uk_biobank can predict different pain conditions and the prognosis of chronic pain up to 9-years later @evp82 @TanguaySabourin

A prognostic risk score for development and spread of chronic pain

Nature Medicine - A risk score developed using biological, psychological and social factor data from the UK Biobank can predict different pain conditions, the risk of chronic pain spreading across...

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4 years

Single-cell #RNAseq identifies a gene signature associated with peripheral #monocyte populations that distinguishes people with #sepsis from those with sterile inflammation and uninfected controls #NMEDClinical @broadinstitute @MGoldbergLab

An immune-cell signature of bacterial sepsis

Nature Medicine - Single-cell transcriptomic analysis identifies a distinct gene signature associated with peripheral monocyte populations that distinguishes people with sepsis from those with...

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2 years

Implantation of a multielectrode paddle that allows personalized electrical stimulation to all regions of the spinal cord involved in leg and trunk movements rapidly restores motor function in spinal cord injury patients with complete paralysis

Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after...

Nature Medicine - Implantation of a multielectrode paddle that allows personalized electrical stimulation to all regions of the spinal cord involved in leg and trunk movements rapidly restores...

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4 years

Single-cell transcriptome and T cell receptor analysis of bronchoalveolar lavage fluid suggests enrichment of proinflammatory macrophages in patients with severe #COVID19 and the presence of clonally expanded CD8+ T cells in those with moderate COVID-19.

Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

Nature Medicine - Single-cell transcriptome and T cell receptor analysis of bronchoalveolar lavage fluid suggests enrichment of proinflammatory macrophages in patients with severe COVID-19 and the...

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9 months

⚡Our August issue is live!⚡ Check out our latest content on #psilocybin 🍄for #anorexia , wearables📳for #Parkinsonsdisease , new clinical trial approaches in #rarediseases , #antivirals against #mpox 🦠and why we need a genomics savvy #healthcare workforce!

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Developed using diverse sources of histopathology images, biomedical text and over 1.17 million image-caption pairs, a visual-language foundation model achieves state-of-the-art performance on a wide array of clinically relevant pathology tasks.

A visual-language foundation model for computational pathology

Nature Medicine - Developed using diverse sources of histopathology images, biomedical text and over 1.17 million image–caption pairs, evaluated on a suite of 14 diverse benchmarks, a...

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4 years

A new study by Marisol Soengas, David Olmeda & cols, shows secretion of MIDKINE by #Melanoma cells modulates anti-tumor #Immunity and determines responses to #Immunotherapy in patients @CNIOStopCancer #Cancer #immunology

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4 years

Prof. Akiko Iwasaki from @YaleMed discusses the pervasive problem of principal investigators who abuse their powers and mistreat their trainees. International trainees are particularly vulnerable, as PIs can hold them hostage with their visas. #academia

Antidote to toxic principal investigators

Nature Medicine - There is a pervasive problem in academia of principal investigators who abuse their powers and mistreat their trainees. Here I share suggestions that would help protect the...

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9 months

A genome-wide meta-analysis of data from 6 US and European cohorts involving 1.3 million individuals identifies 243 genetic variants associated with risk and pathophysiology of depression @AndersBorglum

Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using...

Nature Medicine - A genome-wide meta-analysis of data from six US and European cohorts involving 1.3 million individuals identifies 243 genetic variants associated with risk and pathophysiology of...

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4 months

Lymph node-targeting mutant KRAS peptide vaccine + CpG adjuvant is safe, reduce tumor biomarker expression and elicit mKRAS-specific T cells in patients with #PancreaticCancer & #ColorectalCancer . @MDAndersonNews @ElicioTx @MSKCancerCenter @EileenMOReilly

Lymph-node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer: the...

Nature Medicine - In a phase 1 trial, a lymph node-targeting mutant KRAS peptide vaccine combined with CpG adjuvant is safe, reduces expression of tumor biomarkers and elicits mutant KRAS-specific...

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6 years

The human heart contains 2 types of macrophages with distinct self-maintenance & inflammatory functions. An imbalance between these macrophage types correlates with left-ventricle remodeling & systolic function in patients w/heart failure: #WorldHeartDay

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Autoimmune disease is the next frontier for CAR T cell therapy. News feature by @edbites

Autoimmune disease is the next frontier for CAR T cell therapy

Nature Medicine - CAR T cell therapy has transformed the treatment of B cell cancers and is now being pursued by biotech companies for conditions as varied as systemic lupus erythematosus, diabetes...

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6 years

The human heart contains 2 types of macrophages with distinct self-maintenance & inflammatory functions. A shift in the balance between these macrophage populations correlates with left-ventricle remodeling & systolic function in patients w/heart failure:

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3 months

Understanding the dynamics of the gut #Microbiota over the course of #Cancer treatment regimens and their associated adverse events can help identify microbial features that associate with response to immune checkpoint blockade.

Longitudinal gut microbiome changes in immune checkpoint blockade-treated advanced melanoma

Nature Medicine - Understanding the dynamics of the gut microbiota over the course of cancer treatment regimens and their associated adverse events can help identify microbial features that...

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4 years

A new epidemiological study shows reduced susceptibility to #SARSCoV2 and decreased risk of developing severe symptoms in people aged younger than 20 years, suggesting that children have limited contribution to spread of #COVID19 . @LSHTM @cmmid_lshtm

Age-dependent effects in the transmission and control of COVID-19 epidemics

Nature Medicine - A new epidemiological study shows reduced susceptibility to SARS-CoV-2 and decreased risk of developing severe symptoms in people aged younger than 20 years, suggesting that...

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10 months

Prophylactic use of anakinra, an IL-1 receptor inhibitor, reduced severe #neurotoxicity incidence in patients with r/r #lymphoma treated with anti-CD19 #CARTcells #immunotherapy @jaeparkmd @karthik_nath17 @Michel_Sadelain @MSKCancerCenter @MSK_DeptOfMed

CD19 CAR T-cell therapy and prophylactic anakinra in relapsed or refractory lymphoma: phase 2 trial...

Nature Medicine - Prophylactic subcutaneous administration of anakinra, an IL-1 receptor inhibitor, reduced severe immune effector cell-associated neurotoxicity syndrome incidence in patients with...

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3 years

During the COVID-19 pandemic, the public have turned to scientists and doctors for vital information. But science communication is a skill in itself, so we asked the experts to share their tips. Feature from @polkajunction

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7 months

Gemcitabine + cisplatin + anti-PD-1 led to complete response in 43% of patients with muscle-invasive #BladderCancer , which facilitated bladder sparing and was associated with long-term bladder-intact survival. @MattGalsky @TischCancer @IcahnMountSinai

Gemcitabine and cisplatin plus nivolumab as organ-sparing treatment for muscle-invasive bladder...

Nature Medicine - In a phase 2 trial, the combination of gemcitabine, cisplatin and anti-PD-1 led to a clinical complete response in 43% of patients with muscle-invasive bladder cancer, which...

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1 month

Pretrained using over 100,000 diagnostic histopathological slides across 20 major tissue types, a self-supervised model is shown to outperform existing baselines across various clinically relevant tasks @AI4Pathology @harvardmed

Towards a general-purpose foundation model for computational pathology

Nature Medicine - Pretrained using over 100,000 diagnostic histopathological slides across 20 major tissue types, a self-supervised model is shown to outperform existing baselines across various...

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4 years

EDITORIAL - Government officials who disseminate unsupported claims about the novel coronavirus undermine public trust in science and in the public-health efforts that are essential to bringing the #COVID19 pandemic under control >

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4 years

The gut #microbiome of Irish Travellers, an ethnically distinct sub-population of Ireland, are similar to microbiomes of non-industrialized populations, but externally-imposed #lifestyle changes may alter their microbiota, with potential #health sequelae

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2 years

In our latest Review: Multimodal #AI models could unlock many exciting applications in health and medicine; read about the most promising uses and technical pitfalls to avoid - from @EricTopol @pranavrajpurkar @jn_acosta and @GuidoFalconeMD

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4 years

A smartphone app that combines smartwatch and activity tracker data together with self-reported symptoms allows continuous monitoring of #SARSCoV2 infection #COVID19 #wearables #bioengineering

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7 years

"Designer probiotics" or "Probiotics 2.0" are taking center stage. Read more on these drugs in our newest feature:

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2 years

An early warning system for emerging SARS-CoV-2 variants. Comment from @mvankerkhove @MarionKoopmans @AnuragAgrawalMD and colleagues @WHO #COVID19

An early warning system for emerging SARS-CoV-2 variants

Nature Medicine - Global sequencing and surveillance capacity for SARS-CoV-2 must be strengthened and combined with multidisciplinary studies of infectivity, virulence and immune escape, in order...

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7 years

A new study identifies four distinct neurophysiological biotypes of #depression from fMRI data from >1,000 patients:

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5 years

After anti-PD-1 therapy in basal or squamous cell carcinoma patients, the CD8+ T cell response largely consists of an expanded and exhausted repertoire of new #Tcell clones | #ImmunoTherapy @HowardYChang

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3 years

Human sera from recipients of the BNT162b2 Pfizer-BioNTech vaccine can neutralize SARS-CoV-2 viruses containing spike mutations present in globally circulating variants of concern @utmbhealth #COVID19 #vaccines

Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K and N501Y variants by BNT162b2 vaccine-e...

Nature Medicine - Human sera from recipients of the BNT162b2 vaccine can neutralize SARS-CoV-2 viruses containing spike mutations present in globally circulating variants of concern.

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4 years

In a new strategy for increasing the availability of lungs for #transplantation , human lungs declined because of their poor quality can be recuperated within 24h by connecting them to the circulation of a pig #bioengeneering #physiology #biotechnology

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