A new imaging method follows young neurons in a developing zebrafish as they travel across the embryo and organize themselves into circuits. Read the latest work from Philipp Keller’s lab, published today in
@CellCellPress
.
A new microscope technique shows cells’ fine structure in new detail. The method, developed by Eric Betzig, Harald Hess + colleagues, combines 3D super-resolution fluorescence microscopy and electron microscopy in whole cells. Published today in Science!
This imaging platform brings together 3D super-resolution fluorescence microscopy and electron microscopy—and it works on whole cells preserved cryogenically. It’s revealing the fine inner structure of cells in new detail. Read (and watch) more here:
Researchers
@hhmijanelia
captured release of dopamine across the entire neuron w/ unparalleled spatial resolution using new technology developed by
@BeyeneAbraham
Lab.
▶️
🎥: Dendritic activity around soma of dopamine neuron. Credit: Bulumulla et al.
🦟 By infusing a virtual fruit fly with artificial intelligence,
@HHMIJanelia
and
@GoogleDeepMind
scientists have created a computerized insect that can walk and fly just like the real thing. 🤖
🔗
🔥 Today, researchers unveiled the connectome of the male adult fruit fly nerve cord.
🧠 With about 23K neurons, 10 million pre-synaptic sites & 74 million post-synaptic densities, it’s the most in-depth & complete wiring diagram of a fly nerve cord.
🔗
Presenting: The most detailed map yet of the fruit fly brain. Janelia’s FlyEM team has traced the paths of some 25,000 neurons in the fruit fly brain and pinpointed the places where they connect. Now, all the data is available online for free.
#hemibrain
📢 We’re
#hiring
!
Are you ready to lead a lab? We’re recruiting early career scientists for Group Leader positions across our research areas!
Applications due Nov. 1.
🔗 Learn more and apply at .
#STEMjobs
#academictwitter
Research by Janelia’s Anastasios Pavlopoulos & colleagues harnesses the power of advanced imaging tools to reveal – in stunning detail – the developmental history of limb structures in a developing embryo of a marine crustacean
@mpicbg
[📽️: Wolff et al.]
The
@realMouseLight
Project Team has traced more than 1,000 neurons in the mouse brain. Their paper on this milestone is published today in
@CellCellPress
. Check out the story and video here.
A new two-photon microscope breaks speed limits by compressing data. It can capture neurotransmitter release at hundreds of synapses simultaneously. Check out the latest work from the
@PodgorskiLab
, published today in
@NatureMethods
.
Janelia scientists Philipp Keller and Kate McDole have been awarded 5th place in the Nikon Small World in Motion competition. Their winning entry shows the inside of a developing mouse embryo as the neural plate (which later gives rise to the brain and spinal cord) elongates.
A new microscope from the
#BetzigLab
is essentially 3 scopes in 1. Merging lattice light sheet microscopy & adaptive optics reveals stunning detail. Seen here, clathrin-mediated endocytosis in vivo.
We are excited to announce the permanent head and first cohort of group leaders for our newest research area, 4D Cellular Physiology. They join new group leaders in Mechanistic Cognitive Neuroscience, Molecular Tools & Imaging and Computation & Theory.
🎉 Congratulations to Jennifer Lippincott-Schwartz (
@JLS_Lab
), recipient of the 2023 Dickson Prize in Science from
@CarnegieMellon
for her pioneering work in live-cell imaging & organelle dynamics. 🔬 🦠
🔗
🧪Scientists are creating Janelia Fluor dyes that can act as linkers for other ligands, using them to see brain-wide turnover of proteins & deploying them to record the transcriptional history of cells & examine dendritic biophysics & plasticity rules➡️
Over eight years, Janelia’s FlyLight Project Team and collaborators dissected, labeled, and imaged the neurons of more than 74,000 fruit fly brains, taken from more than 5,000 different genetically modified fly strains. 🧵 (1/9)
🔗
🧠Janelia scientists have reached another milestone in connectomics: A wiring diagram of the fruit fly visual system.
With 50K+ neurons, the optic lobe connectome provides the fullest picture yet of one of the most important parts of the nervous system.
A new paper
@naturemethods
from the Shroff Lab details a new & improved method for processing 3D fluorescence microscopy images that incorporates info about the image formation process into a deep learning network. (1/10)
Janelia Senior Group Leader Jennifer Lippincott-Schwartz (
@JLS_Lab
) will head the 4D Cellular Physiology research area, our new, 15-year research program to understand how cells work and communicate to build and maintain organs and organisms. (1/5)
🎉Congratulations to Andy Moore (
@aaandmoore
), a research specialist in the
@JLS_Lab
, for honorable mention in the 2023
#NikonSmallWorldInMotion
competition for a movie of Endoplasmic reticulum (ER) dynamics in a cultured animal cell.🦠
🔗
When Eric Betzig first saw the results of combining expansion microscopy with lattice light-sheet microscopy, he couldn’t believe the quality of the data. “You could have knocked me over with a feather.”
A smart new microscope has let scientists peek inside a living mouse embryo. Over a 48-hour window, Janelia's Philipp Keller & team can now follow every embryonic cell & pinpoint where it goes, what genes it turns on & what cells it meets on the way:
By tracing the winding paths of neurons in the fly brain, Janelia and
@Google
scientists have constructed the most complete map of the fly brain ever created, pinpointing millions of connections between 25,000 neurons.
🧠 Read more:
Eric Betzig and his Janelia colleagues teamed up with Ed Boyden’s group to image the entire fruit fly brain and sections of mouse brain the thickness of the cortex:
Neuroscience research just got a little bit easier, thanks to the release of tens of thousands of images of fruit fly brain neurons generated by Janelia’s FlyLight Project Team, now detailed in a new paper in
@eLife
.
New ultra-fast jGCaMP8 calcium sensors developed by Yan Zhang,
@LoogerL
,
@janeliagenie
& collaborators, and detailed in a new study
@Nature
, can detect calcium ions nearly as fast as they are released from neurons.
Luke Lavis (
@rhodamine110
),
@jonathangrimm
& collaborators have released the culmination of their years of work on fluorescent dyes: a comprehensive collection of rhodamine-based dyes, the novel chemistry they developed & a roadmap for designing new probes
We're recruiting! Submit your applications for group leader and senior group leader positions in 4D Cellular Physiology by November 15.
Learn more and apply:
Our COSEM Project Team and FIB-SEM Technology group created tools to make annotated 3D images of cells, showing the relationships between different organelles.
Read more:
Congrats to Igor Siwanowicz for his 3rd place win in this year’s Nikon Small World image contest! Igor captured this image of a snail tongue using a confocal microscope, then color-coded it to show the three-dimensionality.
Igor Siwanowicz has been awarded the Royal Photographic Society's Scientific Imaging Award "for his macrophotography images that accentuate the beauty and intricacies of natural forms." Congratulations, Igor!
Glia aren’t just support cells for neurons. New research from the lab of
@MishaAhrens
, published today in
@CellCellPress
, shows that glia can perform computations that tell frustrated fish when to give up.
The new
#OpenScience
Software Initiative will help
@HHMIJanelia
scientists develop and maintain software for biological research. In many cases, these custom, one-of-a-kind computer programs are used by hundreds of biology labs worldwide.
TEMPO, a new tool developed by a team led by Janelia Group Leader
@Isa_Espinosa_M
, is on the cover of
@NeuroCellPress
! TEMPO enables scientists to track & genetically modify consecutive generations of cells in vertebrates, including zebrafish & mice.(1/6)
In 2018, Janelia's Davi Bock and colleagues imaged the complete fly brain in stunning detail: This work is a contender for
@sciencemagazine
's Breakthrough of Year.
Facemap, a new tool developed by
@Atika_Ibrahim
,
@computingnature
,
@marius10p
, Lin Zhong,
@TungRenee
& Will Long, uses a mouse’s facial movements to predict brain activity, helping researchers understand brain-wide signals driven by spontaneous behaviors.
New jGCaMP8 calcium sensors developed
@HHMIJanelia
are more sensitive and nearly 10 times faster than previous versions, enabling scientists to tease out the individual, milliseconds-long signals passing between brain cells. 🧵 (1/7)
🔗
4️⃣ In 2023, Janelia research provided insights into some of biology’s deepest mysteries.
#Janelia2023
🧵 (1/5)
🧠 This includes a new theory about how the brain stores memories
🔗
Scientists have discovered a new kind of synapse in the tiny hairs on the surface of neurons. New study
@CellCellPress
, led by the Clapham Lab &
@Loom19321
, finds these primary cilia could play a key role in how cells communicate long-term changes.
As a postdoc
@HHMIJanelia
, Hari Shroff worked on Nobel Prize-winning super-resolution microscopy techniques. Now, more than a decade later, Shroff is returning to Janelia to again help advance biological imaging as a senior group leader. (1/8)
▶️
9️⃣ New sensors developed at Janelia are helping scientists see like never before. 🦠
#Janelia2023
🧵 (1/3)
⚡ New ultra-fast jGCaMP8 sensors can detect calcium ions nearly as fast as they are released from neurons:
🔗
Congratulations to Jennifer Lippincott-Schwartz, who was awarded
@ASCBiology
's highest honor for science. The E.B. Wilson Medal recognizes far-reaching contributions to cell biology across a career in science.
@JLS_Lab
This week,
@JaneliaFlyEM
& collaborators released the most detailed map yet of the neurons & connections in the fly nerve cord.
The data – detailed in preprints & freely available online – will help scientists figure out how the brain enables behavior.
🔗
🔬 Microscopy is at the essence of Janelia, permeating every part of our scientific, educational & outreach programs.
🥼 Come be a part of our team pushing the limits of scientific imaging & developing the future of imaging science.
🔗 More info ➡️
Congratulations to Andy Moore (
@aaandmoore
), a postdoc in the
@JLS_Lab
, for honorable mention in the
#NikonSmallWorldInMotion
competition for this movie of the cytoskeleton at the edge of a tissue culture cell. Actin (white) and microtubules (blue).
We’re thrilled to welcome Sue Ann Koay as a group leader, starting next summer! Dr. Koay’s work bridges Janelia’s mechanistic cognitive neuroscience and computation + theory research areas. Her lab will study cognitive computations underlying exploration and inference in mice.
Janelia scientists have imaged a complete adult fruit fly brain at nanoscale resolution, offering a new tool for researchers and uncovering new surprises.
🔥 We're
#hiring
imaging experts to help us develop the future of imaging science.🔥
Apply today for current openings in 🔬 instrumentation development, 🧪 sample preparation & biology, and 🖥️ image analysis & software development ▶️
#ScienceJobs
New
@NeuroCellPress
: New version of Voltron, named after an 80s cartoon robot & developed by
@ERSchreiter
Lab &
@janeliagenie
, can detect small fluctuations in signals passing through neurons, enabling greater insight into how brain cells communicate.1/8
A new adaptive, multi-view light-sheet microscope developed at Janelia offers "literally a cellular-resolution building plan of the entire mouse." – Janelia Group Leader Philipp Keller
Starting my own lab at
@HHMIJanelia
next week! Looking for postdocs and students who are interested in neural data science. Work can start remotely. Full ad here:
If you're an early career scientist looking for a pathway to independence in computational or theoretical research, check out our theory fellow program.
Learn more and apply:
If you’ve ever hung out in a darkened basement enjoying a gin and tonic while admiring a Grateful Dead poster under the subtle glow of a black light, then you’ve seen fluorescence in action – even in your drinking glass.
Welcome to our newest Mechanistic Cognitive Neuroscience group leader, Rob Johnson! Rob (
@blobology
) recently completed his PhD at Harvard and will start his lab at Janelia in January, studying how rodents make predictions and plan future actions.
Learn more about Janelia's next research area, 4D Cellular Physiology, at . Subscribe to receive information about upcoming planning workshops and recruitment opportunities.
This animation captures 350 years of light microscopy, from van Leeuwenhoek to present. Don't miss the animated versions of Eric Betzig and Harald Hess.
Powerful microscopes
@hhmijanelia
are enabling researchers to see how individual cancer cells move through blood vessels to colonize other parts of the body. (1/6)
2020:
#ScienceTwitter
acknowledges
@MCHammer
for his scientific outreach
2021: Attends multiple talks and debates
2022: Hammer Lab starts at
@HHMIJanelia
2025: The publication of the paper "How you can touch this" changes our understanding of motor control and tactile perception
Todd Laverty, who manages
@hhmijanelia
’s Drosophila & media prep shared resources, is retiring this month. Laverty started working as a lab manager in Gerry Rubin’s lab
@UCBerkeley
in 1983 & followed Rubin to Janelia to start & run the fly & media facilities.
#WhoIsJanelia
(1/8)
We can't wait to mail some letters with the new
@USPS
Life Magnified stamps, featuring 5 images taken by
@HHMIJanelia
Research Scientist Igor Siwanowicz (Freshwater Protozoans, Moth Antenna, Diving Beetle Foot, Freshwater Snail Tongue & Barnacle Legs)
📢 Attention imaging experts!
We’re hiring for multiple positions in imaging, instrumentation development, sample preparation & biology, and image analysis & software development.
Or submit your CV & cover letter as part of our open call.
🔗
📢We're
#hiring
imaging experts to help us develop the future of imaging science.🔬
✨Apply today for positions in imaging, instrumentation development, sample preparation & biology, and image analysis & software development.🧪
🔗
#ScienceJobs
🐌 Besides its shell, the only hard part of a snail is its tongue. 👅 This snail tongue (or radula), captured at 250x magnification by Janelian Igor Siwanowicz, is made of hundreds of tiny chitinous teeth. Those hard teeth are used to scrape algae off of rocks.
Happy
#FourthofJuly
to everyone in the United States!
@AICjanelia
’s
@JawnnyH
captured these fireworks on the
#LLSM
alongside AIC visitor
@aaandmoore
. Video: dividing cells (actin and mitochondria are stained, color map: red, white, and blue).
Hari Shroff, former chief of the
@NIBIBgov
’s Laboratory of High Resolution Optical Imaging, hopes to push microscopy forward as a new senior group leader in Molecular Tools and Imaging
@hhmijanelia
.
🧠 Want the time to think deeply about science & the freedom to pursue difficult, long-term projects? Apply to be an
@HHMIJanelia
Group Leader by Nov. 22.
We welcome applications from postdocs & grad students ready to start their own lab.
🔗
🔥 A new paper
@NatureBiotech
from the Shroff Lab details new methods to improve super-resolution imaging techniques, giving biologists a clearer and more complete view of the inner workings of living cells. 🧵 (1/7)
“If we, as scientists, manage to climb up one rung on the career ladder, it is our responsibility to reach down with the other hand and pull the next person up.” —Ron Vale, 2019 Canada Gairdner Award winner
New work from the
@JLS_Lab
out today in Nature Cell Biology: A protein that helps regulate cell proliferation pulls far-apart genes together by forming phase-separated droplets in the cell's nucleus.
#Neuropixels
, the new neural-recording technology that lets researchers simultaneously monitor hundreds of neurons throughout an animal's brain, is now available for researchers to purchase.
DYK you don't need a postdoc to apply for our group leader positions? If you are a late-stage graduate student in cell biology, physiology, biophysics, or anatomy, consider applying to lead a lab in 4D Cellular Physiology.
Learn more at
With a new adaptive, multi-view light-sheet microscope and a suite of computational tools, researchers have captured the first view of early organ development inside the mouse embryo:
Meng Wang (
@mengwang939
) first discovered the power of science to unlock the secrets of life in middle school. Today, Wang peers inside organisms & cells to reveal new insights about one of life’s biggest mysteries -- the fundamental mechanisms behind aging & longevity. (1/9)
We are excited to announce that Nelson Spruston (
@nspruston
) has been named Chief of Janelia Scientific Operations and Programs, a new leadership position focused on implementing
@HHMIjanelia
’s strategic vision.
👽 While it looks alien, this cluster of spore-bearing sporangia called sorus can be found on the underside of a fern frond, in this case, a tiny polypody fern, Polypodium virginianum. Captured and stained by Janelian Igor Siwanowicz.
Desmidiliaes comprises more than 8000 species of single-cell freshwater algae worldwide, exhibiting vast diversity of shapes & sizes. Desmids, like these captured by Janelian Igor Siwanowicz, prefer nutrient-poor, slightly acidic water & have low tolerance for heavy metals. 🎸
.
@sciencemagazine
is choosing the 2018 science breakthrough of the year and one candidate is techniques that let researchers track organism development cell by cell—techniques that Philipp Keller’s team is using to look inside living mouse embryos:
🐭 Facemap, a new freely available tool developed by researchers
@HHMIJanelia
, uses deep neural networks to relate information about a mouse’s eye, whisker, nose, and mouth movements to neural activity in the brain. 🧠
🔗
Congratulations to Jim Truman, professor emeritus
@UW
and a member of the
@HHMIJanelia
community, on being elected to
@theNASciences
!
📸 Jim finding out the news today on campus with his wife, Lynn Riddiford, also a professor emeritus
@UW
and a member of
@theNASciences
.
We're looking for creative scientists to lead labs in Mechanistic Cognitive Neuroscience. Our labs are small and internally funded. Postdoctoral experience is not required.
#SfN19
For the past decade, Luke Lavis (
@rhodamine110
) and his team have been creating and perfecting the Janelia Fluor dyes. Now, they’re working with biologists to design dyes for specific biological applications.
We’re thrilled to welcome Alison Tebo (
@agtebo
) as a new group leader at Janelia starting in September 2020. She’ll continue her protein engineering work here, building molecular tools to study interactions between cells in the brain and beyond.
We are recruiting a new director for our Janelia Experimental Technology (jET) team. jET designs, builds, and tests custom instruments, microscopes, tools, and software. [1/3]
New work from Eric Betzig and team reveals the most detailed picture yet of subcellular dynamics in multicellular organisms.
#lightsheetmicroscopy
#adaptiveoptics