Marraffini Lab @MarraffiniLab Twitter profile

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Marraffini Lab

@MarraffiniLab

4 years

What better to celebrate the new year than phage fireworks? (S.aureus being lysed by Sa2 phage, cell DNA in green) Photo by @pmaguin , tweet by Luciano. Happy 2020!

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Marraffini Lab

@MarraffiniLab

2 years

It was an immense honor to be elected by the @americanacad and sign the historic book (tweet by Luciano)

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Marraffini Lab

@MarraffiniLab

3 months

Immigrants contribute so much to US science!! I am extremely humbled and grateful to have been selected among them. Thank you @Vilcek for doing such important and thoughtful work! (Post by Luciano)

The Vilcek Foundation

@Vilcek

3 months

🧬 Join us as we congratulate the recipients of the 2024 @Vilcek Foundation Prizes in #BiomedicalScience : @MarraffiniLab , @Gerta_Hoxhaj , @LabNowakowski , & @TakebeLab ! Comprising $250K in awards, the prizes recognize #immigrant scientists in the US!

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Marraffini Lab

@MarraffiniLab

18 days

Congrats ⁦ @amer_hossai1 ⁩ for the great work on anti-phage DNA glycosylases!! Thanks to our collaborator Phoebe Rice, and also Sean Brady and Joshua Chappie.

DNA glycosylases provide antiviral defence in prokaryotes

Nature - A screen utilizing an environmental DNA library in Escherichia coli is used to identify Brig1, a previously unknown anti-phage defence system with homologues across distinct clades of...

www.nature.com

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Marraffini Lab

@MarraffiniLab

2 years

Have you ever wondered if there is a link between CRISPR and restriction, besides being the source of awesome genetic technologies? You can find the answer in @pmaguin paper. Congrats Pascal! Thanks @andrewjvarble and @jwmodell too.

Cleavage of viral DNA by restriction endonucleases stimulates the type II CRISPR-Cas immune response

Restriction and CRISPR-Cas nucleases cleave phage DNA. Maguin et al. show how these are coordinated to defend bacteria from infection. Restriction provides initial protection and also generates free...

www.cell.com

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Marraffini Lab

@MarraffiniLab

3 years

In 2008 we proposed with @ESontheimerLab that the DNA targeting properties of #CRISPR could be applied outside prokaryotes. Today @Intelliatweets published groundbreaking work using #CRISPR for in vivo therapeutic editing!Congrats ⁦ @intelliatweets team!

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Marraffini Lab

@MarraffiniLab

2 years

After 15 years of work on type III CRISPR immunity, we finally detected spacer acquisition, with cool results! Congrats to @NaamaAviram and collaborators Ashley Thornal and @DaveZeevi !!

Different modes of spacer acquisition by the Staphylococcus epidermidis type III-A CRISPR-Cas system

Abstract. CRISPR-Cas systems provide prokaryotic organisms with an adaptive defense mechanism that acquires immunological memories of infections. This is a

academic.oup.com

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Marraffini Lab

@MarraffiniLab

7 months

Hey #CRISPR people! We made it to the NYT crossword! I couldn’t have imagined something like this when I did my first experiments in 2006 (tweet by Luciano)

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Marraffini Lab

@MarraffiniLab

1 year

Congrats to @daltonbanh and @camgroberts for their work that found how a CBASS cyclase binds phage RNA to initiate immunity. Big thanks to our collaborators Sean Brady and Adrian Morales Amador

Bacterial cGAS senses a viral RNA to initiate immunity

CBASS immunity protects prokaryotes from viral (phage) attack through the production of cyclic dinucleotides which activate effector proteins that trigger the death of the infected host. How bacter...

www.biorxiv.org

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Marraffini Lab

@MarraffiniLab

6 months

Congrats to ⁦ @camgroberts ⁩, ⁦ @daltonbanh ⁩ and collaborators at the Brady Lab ⁦ @RockefellerUniv ⁩ for their work CBASS activation by phages

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Marraffini Lab

@MarraffiniLab

4 years

Congratulations to Jennifer and Emmanuelle!

The Nobel Prize

@NobelPrize

4 years

BREAKING NEWS: The 2020 #NobelPrize in Chemistry has been awarded to Emmanuelle Charpentier and Jennifer A. Doudna “for the development of a method for genome editing.”

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Marraffini Lab

@MarraffiniLab

3 years

Congrats @jakob_tr for a successful thesis defense!! Many thanks to the members of his committee for all the support over the years. Special thanks to Joseph Mougous.

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Marraffini Lab

@MarraffiniLab

3 years

Congrats ⁦ @CharlieMo8 ⁩, Jacob Mathai and the test on the team for their latest publication about how CRISPR can promote mutagenesis. Well done!

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Marraffini Lab

@MarraffiniLab

4 months

Congrats to ⁦ @ChristianF_Baca ⁩, ⁦ @jakob_tr ⁩ and collaborators Yu You and ⁦ @PujaMajumder91 ⁩ from the Patel lab for their study on a unique transmembrane CARF effector!!

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Marraffini Lab

@MarraffiniLab

1 year

Argentina campeón del mundo!!! Todavía no lo puedo creer (tweet by Luciano)

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Marraffini Lab

@MarraffiniLab

5 months

The Rockefeller University » A CRISPR pioneer looks back as the first gene-editing therapy is approved

A CRISPR pioneer looks back as the first gene-editing therapy is approved - News

Luciano Marraffini’s research helped lay the groundwork for the newly FDA-approved CRISPR-based therapy for sickle cell anemia.

www.rockefeller.edu

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Marraffini Lab

@MarraffiniLab

4 years

Congrats ⁦ @PNussenzweig ⁩ for a terrific thesis (online) defense!!

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Marraffini Lab

@MarraffiniLab

4 years

We’ve been doing experiments for 10 years today. Thanks to all that were part of this milestone!!

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Marraffini Lab

@MarraffiniLab

3 years

Congrats @jakob_tr for the EMBO Fellowship! Now your fun and hard work at @jrpenades Lab will be nicely funded!

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Marraffini Lab

@MarraffiniLab

1 year

congratulations @hey_its_nia for the NSF GRFP fellowship! So deserved! Work on the proposed aims will start right after cookie celebration.

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Marraffini Lab

@MarraffiniLab

8 months

1st @MarraffiniLab student, @jiang_wenyan , stopped by to visit. Good luck starting your own lab at @MountSinaiNYC !

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Marraffini Lab

@MarraffiniLab

3 months

Congrats to @NaamaAviram and @AKShilton for their amazing work on the mechanism of regrowth after dormancy during the type III CRISPR response! Thanks to @hey_its_nia , @Bernardo_S_Reis and @brivanlou for their help!

The Cas10 nuclease activity relieves host dormancy to facilitate spacer acquisition and retention...

A hallmark of CRISPR immunity is the acquisition of short viral DNA sequences, known as spacers, that are transcribed into guide RNAs to recognize complementary sequences. The staphylococcal type...

www.biorxiv.org

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Marraffini Lab

@MarraffiniLab

11 months

Congrats @daltonbanh for his PhD defense! Student #10 from @MarraffiniLab

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Marraffini Lab

@MarraffiniLab

1 year

Farewell to @andrewjvarble . Best of luck starting your lab @URMC_MBI_IMV !!!

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Marraffini Lab

@MarraffiniLab

1 year

one more about the Argentina world cup win...

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Marraffini Lab

@MarraffiniLab

17 days

Wonderful talk by ⁦ @camgroberts ⁩ on her CBASS work at the Symposium of the immune systems of bacteria!

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Marraffini Lab

@MarraffiniLab

4 months

it is an amazing honor to be recognized by @GeneticsGSA . Thank you! (post by Luciano)

Preeminent geneticists recognized with revamped GSA Awards

In 2022, GSA’s Board of Directors launched an audit to review the five major awards conferred by the Society. Today, we are thrilled to announce the recipients of the reimagined GSA Awards, including...

genestogenomes.org

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Marraffini Lab

@MarraffiniLab

3 years

Congrats to @jakob_tr , all the people that helped him and especially our collaborators at the Patel Lab, for his new paper on a novel CARF nuclease associated with #CRISPR ! The Card1 nuclease provides defence during type-III CRISPR immunity

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Marraffini Lab

@MarraffiniLab

6 months

Congrats to our long-distance runners Clare Cahir and Alice Cassel for their performance at the #nycmarathon2023

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Marraffini Lab

@MarraffiniLab

3 years

Best of luck @UW . Goddbye @alexjmeeske ...

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Marraffini Lab

@MarraffiniLab

4 years

We will think about how we can undertake anti-racist efforts in our lab and in science in general. We support #ShutDownAcademia #ShutDownSTEM 10 June 2020

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Marraffini Lab

@MarraffiniLab

3 years

Congrats @amer_hossai1 , @jwmodell and their coauthors for their latest #CRISPR work!

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Marraffini Lab

@MarraffiniLab

2 years

welcome to our new students @scientistcalvin @hey_its_nia @camgroberts @amejiap97 !!

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Marraffini Lab

@MarraffiniLab

1 year

Farewell to @CharlieMo8 . Best of luck starting your lab @UWBact !!!

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Marraffini Lab

@MarraffiniLab

4 years

Congrats to ⁦ @alexjmeeske ⁩ for his paper on Cas13 inhibition in collaboration with the Patel lab. Thanks ⁦ @alicekcassel ⁩ and Albina Kozlova for all the help!

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Marraffini Lab

@MarraffiniLab

11 months

Congrats Claire Kenney for her work on non-canonical PAM sequences!

Rarely acquired type II-A CRISPR-Cas spacers mediate anti-viral immunity through the targeting of a...

Abstract. The Streptococcus pyogenes type II-A CRISPR-Cas systems provides adaptive immunity through the acquisition of short DNA sequences from invading v

academic.oup.com

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Marraffini Lab

@MarraffiniLab

7 months

Congrats @scientistcalvin for a successful TRP defense! Appropriately celebrated with delicious indonesian food

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Marraffini Lab

@MarraffiniLab

5 months

Congrats @amer_hossai1 for a fantastic thesis defense!

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Marraffini Lab

@MarraffiniLab

1 year

Fantastic Friday Lecture by @michael_laub8 ! And great dinner to welcome Mike with Seth Darst, Jeremy Rock @RockLabTB , Liz Campbell and @vivrisca . Thanks for coming Mike! (tweet by Luciano)

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Marraffini Lab

@MarraffiniLab

4 years

Congrats to @andrewjvarble for his finding of a new way used by prophages to inhibit #CRISPR

Integration of prophages into CRISPR loci remodels viral immunity in Streptococcus pyogenes

CRISPR loci are composed of short DNA repeats separated by sequences that match the genomes of phages and plasmids, known as spacers. Spacers are transcribed and processed to generate RNA guides used...

www.biorxiv.org

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Marraffini Lab

@MarraffiniLab

6 months

Congrats @ScientistGianna for her review on recent advances in Type III CRISPR immunity!

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Marraffini Lab

@MarraffiniLab

10 months

Welcome @KaileySlavik to the lab and Happy birthday! Happy birthday to @RaHofmann too! Thanks to @AKShilton for the cakes.

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Marraffini Lab

@MarraffiniLab

4 years

Welcome Hyejin to the lab!! Our newest MD/PhD student from @TriIMDPhD

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Marraffini Lab

@MarraffiniLab

2 years

in-person b-day celebrations are back! Best wishes to Claire Kenney, @scientistcalvin and our new lab member @paigearnold2 !

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Marraffini Lab

@MarraffiniLab

7 months

Our very own @ChristianF_Baca slashing guitar at THE UNIVERSITY OF ROCK concert last Friday. Good show!

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Marraffini Lab

@MarraffiniLab

7 months

Congrats @hey_its_nia for a successful defense of the TRP exam! Deserved celebration with gelato too!

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Marraffini Lab

@MarraffiniLab

3 years

Adios barrilete cosmico... QDEP #Maradona (tweet by Luciano)

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Marraffini Lab

@MarraffiniLab

3 years

Congrats to alumnus ⁦ @jwmodell ⁩ and his team for this amazing discovery and paper!!

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Marraffini Lab

@MarraffiniLab

4 years

Welcome Gianna Stella to the lab!! Another amazing PhD student recruit it by @TPCB_NYC !

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Marraffini Lab

@MarraffiniLab

4 years

Congratulations to @jiang_wenyan (our former student) from @s_tavazoie lab for this great paper in Cell! Comprehensive Genome-wide Perturbations via CRISPR Adaptation Reveal Complex Genetics of Antibiotic Sensitivity: Cell

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Marraffini Lab

@MarraffiniLab

3 years

I am having CRISPR talk withdrawals this morning... Thank you @dbikard @StinekevanHoute @crisprcas10 and @CRISPRchef for for all your work to "adapt" to the virtual environment and organize a truly fantastic CRISPR meeting! And for making me the keynote speaker.

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Marraffini Lab

@MarraffiniLab

1 year

the @MarraffiniLab World Cup contest is in full swing!

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Marraffini Lab

@MarraffiniLab

2 years

Belated congrats to ⁦ @pmaguin ⁩ for a fantastic thesis defense!

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Marraffini Lab

@MarraffiniLab

4 years

Thanks ⁦ @ESontheimerLab and ⁦ @CRISPRchef ⁩ for the great synopsis of our recent paper! Shutting down RNA-targeting CRISPR | Science

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Marraffini Lab

@MarraffiniLab

4 years

I wanted to thank @aaronwhiteley for giving such a great seminar via Zoom today for our @RockefellerUniv community. Fantastic work! (Tweet by Luciano)

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Marraffini Lab

@MarraffiniLab

4 years

Congrats ⁦ @norapyenson ⁩ for her paper CRISPR spacer acquisition within colonies!! Co-evolution within structured bacterial communities results in multiple expansion of CRISPR loci and enhanced immunity | eLife

Co-evolution within structured bacterial communities results in multiple expansion of CRISPR loci...

Cells must acquire multiple viral spacer sequences to neutralize mutant escaper phages and form colonies during the CRISPR-Cas immune response.

elifesciences.org

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Marraffini Lab

@MarraffiniLab

8 months

Happy birthday @hey_its_nia , @paigearnold2 and @scientistcalvin !

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Marraffini Lab

@MarraffiniLab

4 years

congrats to Roberto Bonasio @PennEpiInst and Luciano for this wonderful recognition

Humboldt-Stiftung

@AvHStiftung

4 years

Congratulations! 🥳 #MaxPlanckHumboldt2020 for Roberto Bonasio for his outstanding research in the field of #epigenetics , #MaxPlanckHumboldtMedal2020 to Luciano Marraffini for his achievements in #CRISPRCas ! @maxplanckpress

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Marraffini Lab

@MarraffiniLab

1 year

@shsternberg gave an amazing talk yesterday @RockefellerUniv and we celebrated with a great dinner along Seth Darst, Elizabeth Campbell and @RockLabTB . Thanks for visiting Sam!

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Marraffini Lab

@MarraffiniLab

6 months

Congrats to @amejiap97 for a successful TRP defense!

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Marraffini Lab

@MarraffiniLab

4 years

Congrats @alexjmeeske for the 2020 Tri-Institutional Breakout Prize! Well deserved!!

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Marraffini Lab

@MarraffiniLab

3 years

Congrats @PNussenzweig !! A great honor.

Tri-I MD-PhD

@TriIMDPhD

3 years

Congratulations to the winners of the inaugural Olaf S. Andersen Physician Scientist Award @S__Baksh , @PNussenzweig , and @spikesandwaves ! A well-deserved honor by all.

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Marraffini Lab

@MarraffiniLab

3 years

Good job @daltonbanh !!

Tri-I MD-PhD

@TriIMDPhD

3 years

Congrats to Dalton Banh on receiving an @NIH F30 award! This grant will support Dalton's project "Elucidating how CRISPR-Cas Modulates the Spread of S. aureus Pathogenicity Islands" in the @MarraffiniLab at @RockefellerUniv . Read more about Dalton:

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Marraffini Lab

@MarraffiniLab

4 years

Welcome @ChristianF_Baca to the lab!! Thanks to ⁦ @TPCB_NYC ⁩ for recruiting amazing students!

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Marraffini Lab

@MarraffiniLab

5 years

Congratulations @PNussenzweig on type II priming paper @cellhostmicrobe ?¿returnURL=

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Marraffini Lab

@MarraffiniLab

8 months

the lab (mainly @ScientistGianna and @hey_its_nia ) welcomed back @ChristianF_Baca with a "wrapped bench" present. Good to have you back Christian!

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Marraffini Lab

@MarraffiniLab

2 years

Happy birthday @hey_its_nia !!

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Marraffini Lab

@MarraffiniLab

6 months

Halloween labmeeting by @ChristianF_Baca

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Marraffini Lab

@MarraffiniLab

3 years

Congrats to @alexjmeeske for his new position at University of Washington. You will be missed!!!

alex meeske

@alexjmeeske

3 years

I'm starting my lab at the @UW Dept of Microbiology next month - so excited to be joining a fantastic group of scientists and exploring CRISPR and phages on the west coast! Check out for positions and more info

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Marraffini Lab

@MarraffiniLab

4 years

Congrats Claire for the NIH Fellowship!! MD-PhD Student Awarded NIH Grant

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Marraffini Lab

@MarraffiniLab

3 years

...and welcome Maj! New postdoc from the @Basler_Lab

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Marraffini Lab

@MarraffiniLab

10 months

Congrats @ScientistGianna , recipient of the @TPCB_NYC Student Service Award!

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Marraffini Lab

@MarraffiniLab

6 months

Happy birthday Phone! Thanks for all you do for the lab!

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Marraffini Lab

@MarraffiniLab

9 months

@MarraffiniLab watching #OppenheimerMovie . Thanks Clare Cahir for organzing!

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Marraffini Lab

@MarraffiniLab

2 years

Returning lab tradition: binging #StrangerThings4 , this time with croissants from l’appartment 4F

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Marraffini Lab

@MarraffiniLab

11 months

Happy birthday @AKShilton !!

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Marraffini Lab

@MarraffiniLab

4 years

Welcome Allison, our new lab manager, to the lab!!

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Marraffini Lab

@MarraffiniLab

5 months

Happy birthday @hyej_kim !

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Marraffini Lab

@MarraffiniLab

5 years

congratulations to @daltonbanh for successfully defending his Thesis Research Proposal!

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Marraffini Lab

@MarraffiniLab

1 year

happy birthday Alice and @CharlieMo8 !

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Marraffini Lab

@MarraffiniLab

1 year

Congrats @paigearnold2 for this amazing fellowship! Thanks to @Simons_SOF for supporting young scientists!

Simons Society of Fellows

@Simons_SOF

1 year

We are pleased to introduce the 2023 Junior Fellows of the Simons Society of Fellows! The fellows hold expertise in a diverse range of fields, including neuroscience, biophysics and number theory.

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Marraffini Lab

@MarraffiniLab

3 years

Thanks to @BalskusLab from @HarvardCCB for the great talk on Friday at @RockefellerUniv , discovering the amazing (and dangerous!) chemistry of gut bacteria.

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Marraffini Lab

@MarraffiniLab

3 years

Happy birthday @RaHofmann , Jacob and Luciano. Delicious cakes by @AKShilton , as always

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Marraffini Lab

@MarraffiniLab

3 years

The @Vilcek Foundation has launched an online celebration of the 2021 #VilcekPrizes honoring #immigrant scientists and innovators! Congratulations to @REMLehmann , @donialab , @ibrahimcisse_ , @RouskinLab and all of this year's honorees! (tweet by Luciano)

2022 Vilcek Foundation Prizes

Diverse perspectives empower creative solutions: celebrating the winners of the 2022 Vilcek Foundation Prizes.

gala.vilcek.org

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Marraffini Lab

@MarraffiniLab

4 years

Happy birthday Naama and Phone!!

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Marraffini Lab

@MarraffiniLab

3 years

Mil gracias a todo el equipo de @TEDxRdelaP por la invitación y la producción de mi charla! (tweet by Luciano)

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Marraffini Lab

@MarraffiniLab

4 years

Luciano's interview with the @CRISPRjournal CRISPRJournal is now online:

GuidePost Ep. 16: Luciano Marraffini, big time microbiologist

A discussion with Luciano Marraffini, the Rockefeller University microbiologist who has made several fundamental contributions in the brief history of CRISPR biology and genome editing.

soundcloud.com

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Marraffini Lab

@MarraffiniLab

4 years

congratulation to former student @jontmcginn investigating Rickettsia pathogenesis in @lamasonlab for being awarded the Damon Runyon Fellowship!!

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Marraffini Lab

@MarraffiniLab