Ayush Noori @ayushnoori Twitter profile | Pikagi

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Ayush Noori

@ayushnoori

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1,327

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Student @Harvard researching AI for neuroscience at @HarvardDBMI , @WyssInstitute , @MGHNeurology to advance human health. Tweets/RT = my own.

Cambridge, MA

https://t.co/huAGjcrzlL

Joined August 2020

Don't wanna be here? Send us removal request.

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@ayushnoori

Ayush Noori

7 months

Excited to deliver the next CCB Seminar at @harvardmed . Looking forward to sharing our ongoing work in @marinkazitnik 's lab on multimodal deep learning for drug repurposing and precision medicine. 🗓️ Date: Monday, October 30th 🕒 Time: 3PM ET 📍Location: @HMSCountway or Zoom

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@ayushnoori

Ayush Noori

3 months

Some have speculated that @OpenAI 's Sora was trained on @UnrealEngine 5. New work uses UE5 to render CryoET datasets with millions of molecules in complex biological scenes: What if we could put 2 + 2 together, and finetune Sora for biology viz?

@ayushnoori

Ayush Noori

3 months

Video and images are time and labor intensive to produce. When Sora was announced by @OpenAI , some of my favorite prompting requests – whether joking or not – were to visualize biological phenomena or objects like cells and proteins. 4/9

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@ayushnoori

Ayush Noori

4 months

In a @ScienceMagazine editorial, David Baker @UWproteindesign and @geochurch propose encrypted global screening and tracking of all synthesized DNA sequences. 🧬 In an emergency, a “selective revelation” policy would allow tracing design history. 🚨 1/3

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Protein design meets biosecurity

The power and accuracy of computational protein design have been increasing rapidly with the incorporation of artificial intelligence (AI) approaches. This promises to transform biotechnology,...

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@ayushnoori

Ayush Noori

1 month

Grateful and excited to share that I have been named a 2024 Barry Goldwater Scholar. I have many to thank for this honor, starting with my mentors @marinkazitnik , @geochurch , @jenny_m_tam , and @sdas617 . 1/4

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@ayushnoori

Ayush Noori

8 months

Excited to share that I’ve been selected as a 2023 Time Fellow. ⏳ I’m grateful for the support of @time_initiative (led by @c_hudpaz ) and @AFARorg . Towards a world free of age-related disease! 1/3

@time_initiative

Time Initiative

@time_initiative

8 months

🚀 Introducing our 2023 Time Fellows! These trailblazers are gearing up to redefine the future of aging research. Exciting times ahead as they embark on this transformative journey! Check out the faces behind the brilliance. 🌟 #TimeInitiative #aging #agingbiology

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@ayushnoori

Ayush Noori

7 months

Exciting talk by @yusufroohani at the Stanford Graph Learning Workshop on universal cell embeddings learned from @cziscience CELLxGENE single-cell data: - 🖥️ 500+ datasets, - 🧫 45M cells, and - 🔬 682 cell types projected into one single embedding space. 1/2

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@jure

Jure Leskovec

7 months

Join us for the 3rd Stanford Graph Learning Workshop. Live stream is starting in less than 12 hours -- Tuesday Oct 24 at 9am PST. 📢 Program: Live stream at:

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@ayushnoori

Ayush Noori

7 months

Biology is an “engineering discipline waiting to be unlocked.” 🗝️ – @srikosuri @OctantBio is a legendary choice to kickstart the S³ five-episode biology blackout month. 1/5

@jasonjoyride

Jason Carman

7 months

What does synthetic biology, chemistry, robotics, and AI have in common? They're all being used by @OctantBio to discover new drugs for previously untreatable diseases. Episode 15 of S³ dives deep into the new and cutting edge world of drug discovery.

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@ayushnoori

Ayush Noori

2 years

Earlier this month, I attended the phenomenal @foresightinst Designing Molecular Machines Workshop, organized by @allisondman and team, hosted at @indbio in SF, and chaired by William Shih, @AdamMarblestone , and @Ben_Reinhardt . Here’s what I learned! 1/11

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@ayushnoori

Ayush Noori

1 month

Tour-de-force keynote from @reshmapshetty , co-founder of @Ginkgo , on automation and AI to engineer biology. Reshma quotes @nvidia ’s Jensen Huang, “Biology has the opportunity to be engineering not science.” Thank you, @reshmapshetty , for sharing your vision of the future. 👇🏽

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@ayushnoori

Ayush Noori

3 months

I’ve been eagerly awaiting the first foundation model to fulfill the central dogma: a language model for DNA, RNA, and proteins. 🧬 Thanks to @pdhsu @BrianHie and team at @arcinstitute , it’s finally here. Upon first read of this paper, Evo looks really exciting and impactful.

@pdhsu

Patrick Hsu

3 months

Is DNA all you need? In new work, we report Evo, a genomic foundation model that learns across the fundamental languages of biology: DNA, RNA, and proteins. Evo is capable of both prediction tasks and generative design, from molecular to whole genome scale.

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@ayushnoori

Ayush Noori

11 days

This is one of those papers that makes you marvel at the human brain. “This connectome describes a piece of human brain tissue the size of half a grain of rice that nonetheless requires 1.4 petabytes (1.4 million gigabytes) to encode...” 1/2

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@GoogleAI

Google AI

12 days

This year is the 10th anniversary of the Google Research’s Connectomics team! In celebration, today with @MCB_Harvard we’re publishing a 1.4 petabyte human brain connectome with 57k cells and 150M synapses in @ScienceMagazine → &

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@ayushnoori

Ayush Noori

8 months

Full house, and then some, for @james_y_zou ’s talk at @HarvardDBMI today on “Biomedicine in the age of generative AI,” hosted by @zakkohane . If the turnout and enthusiasm is any indication, this is exciting research at the frontier of generative AI. 1/4

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@ayushnoori

Ayush Noori

2 years

Our latest paper is out now in @jmirpub : . Together with my co-first author @ColinMagdamo and our incredible team at @MassGenBrigham , we developed a semi-automated NLP-powered annotation tool (NAT) to facilitate phenotyping of cognitive status. 🧵 1/15

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Development and Evaluation of a Natural Language Processing Annotation Tool to Facilitate Phenoty...

Background: Electronic health records (EHRs) with large sample sizes and rich information offer great potential for dementia research, but current methods of phenotyping cognitive status are not...

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@ayushnoori

Ayush Noori

2 years

Small feature from @rstudio with an outsized impact for (e.g.) data visualization and ggplot2 fans. Thanks @romain_francois and others!

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Show colors in R mode strings by romainfrancois · Pull Request #11546 · rstudio/rstudio

Intent addresses #5424 Approach adapt ace so that token objects may have a style property that is meant to be used as style= of the r highlight rules use it to recognize and style &qu...

@philmassicotte

Philippe Massicotte

@philmassicotte

2 years

Nice to see the daily build of #rstudio supporting colour preview #rstats

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@ayushnoori

Ayush Noori

7 months

The gang is back together again: @NucleateDojo , SF edition. Spending time with my friends in the same place at the same time always makes me excited and hopeful for the future of innovation in biology. 🤩 @MichaelTrinh18 @SeyoneC @_Carol_Mag @RikardSaqe @maggie_1i @mikegeecmu

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@ayushnoori

Ayush Noori

3 years

One marvelous week into statistical mechanics, here's a tweet of a photo of a tweet of an apt photo (courtesy of the LS50 TFs and @quantian1 ). The next line of Goodstein's introduction reads, "Perhaps it will be wise to approach the subject cautiously."

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@ayushnoori

Ayush Noori

1 month

Excited to invite all students to the @harvardopenbio Future of Biology Conference 2024! We are lucky to have an incredible speaker line-up, incl.: 🧬 - @geochurch ( @harvardmed ) 🌱 - @reshmapshetty ( @Ginkgo ) 🦾 - @DrRituRaman ( @MIT ) 🧫 - @jgooten + @omarabudayyeh ( @mcgovernmit )

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@ayushnoori

Ayush Noori

2 years

The only thing better than the plant-based food 🌱 (ft. delicious “chicken” nuggets from @RebellyousFoods ) at the @fiftyyears summer party last night was the incredible company and conversation. 1/10

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@ayushnoori

Ayush Noori

2 years

New #TranslationPodcast episode out now! I chat with @jykishi , former Technology Development Fellow at @wyssinstitute , about her new @naturemethods paper on Light-seq, a breakthrough spatial sequencing method that’s both accessible and precise. 🎙️: 1/14

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@ayushnoori

Ayush Noori

10 months

Tour of the new @wyssinstitute space at 201 Brookline Ave, T-7 days until the move! Excited to work in this incredible building with @geochurch @jenny_m_tam and team. 1/2

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@ayushnoori

Ayush Noori

2 years

The last remaining table at the @pillar_vc and @DnaDeviants bio dinner last night before the venue closed at 10PM. The conversation was too riveting to leave! Photo courtesy of @Sana_Rfzz , also ft. @SyntheticRabbit , @chorye , @yasmeenbrain , and @dj_mandell .

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@ayushnoori

Ayush Noori

7 months

It’s 5AM in Boston and this @Harvard crew is headed from BOS to SFO for the @time_initiative Fellowship Retreat! ✈️ See you soon, @_Carol_Mag @MichaelTrinh18 @RikardSaqe @c_hudpaz . 🙌🏽 Friends in the Bay Area, drop me a line if you’re free for coffee! ☕️

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@ayushnoori

Ayush Noori

2 years

Kickstarted the new year by diving deep into the mechanics of impact-driven biotechnology entrepreneurship with @fiftyyears . Excited to continue learning how great founders leverage science to solve critical global challenges, and grateful to be a part of this team!

@sethbannon

Seth Bannon 🌻

2 years

New year, new @fiftyyears team members! Give a warm welcome to @ATrotmanGrant , @sarakemppainen , @ayushnoori ! More about these new Happy Warriors 👇

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@ayushnoori

Ayush Noori

2 years

I'm excited to share our latest work: . Together with my co-first author, Clara Muñoz Castro, we developed a novel protocol of multiplex IHC on human postmortem #brains followed by #deeplearning image analysis to study glial reactions in #Alzheimers . 1/6

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@ayushnoori

Ayush Noori

11 days

“I'm going to say something provocative... interpretability is hopeless. There's no reason that something like a signaling pathway, with millions of interacting components, should be comprehensible to our human neural architecture.” – @MoAlQuraishi at @gembioworkshop 1/n

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@ayushnoori

Ayush Noori

2 years

Day 2 of the @NucleateHQ Summit underway at @RoyaleBoston ! Great conversation already flowing. 🥳

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@ayushnoori

Ayush Noori

2 months

Grateful to be supported by a @time_initiative Fellowship Grant for research with @marinkazitnik advancing AI for precision longevity medicine. ⏳ Thank you @c_hudpaz @AlexJColville @LauraDeming and team for the opportunity to work towards healthy and dignified aging. 1/4

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@time_initiative

Time Initiative

@time_initiative

2 months

Congratulations Time Fellowship Grant Awardees for pioneering groundbreaking projects in aging biology! They’re investigating the aging brain, long-lived bats, and leveraging AI for longevity medicine. See all 12 grant winners here. #AgingBiology #aging

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@ayushnoori

Ayush Noori

1 month

Thanks to @age1vc and @StrandTx for organizing a great Boston longevity biotech meet-up this evening. Enjoyed catching up with @KKajderowicz , @DrSynbio , @AlexJColville , @ashleevance , @ceghadban , @MichaelShadpour , @_emmarosewest , @amplesa , @MukundhMurthy , and many other friends.

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@ayushnoori

Ayush Noori

8 months

Today was @HarvardDBMI ’s 5th Annual Science Day, hosted at @Merck . What a day. Incredible convergence of groundbreaking biomedical research and tight-knit scientific community. @AdaFang_ and I from @marinkazitnik ’s lab were poster neighbors! 1/2

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@ayushnoori

Ayush Noori

2 years

Much love and appreciation for @subaita_rahman and the team at @NucleateDojo (esp. @MichaelTrinh18 and @BrandonOliverYu ), who I’ve truly enjoyed working with to empower undergrads passionate about life sciences innovation. We’re in the exponential phase now! 📈

@subaita_rahman

Subaita Rahman

@subaita_rahman

2 years

If you haven’t met @ayushnoori you need to!! One of the most kindest & smartest people I know (also very humble haha), so glad he’s part of the @NucleateDojo team leading partnerships! Shoutout to @ATrotmanGrant for introducing him to the dojo team!

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@ayushnoori

Ayush Noori

8 months

Packed room for dessert night with @cory and the Harvard/MIT undergrad builder crowd. 🍪 Enjoyed thought-provoking convos with @walden_yan @ayushmenon_ @ronawang @raffi_hotter @kocalars @karunkaushik_ and many others.

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@cory

Cory Levy

8 months

this Thursday evening at Harvard co-hosting a dessert night 🍪 🍪 🍪 DM or @reply if you are in Boston and want to come (Limited to 40 people)

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@ayushnoori

Ayush Noori

7 months

Thank you to those who attended today, both in-person and virtually. We had > 55 attendees, the most widely attended CCB Seminar thus far. Very grateful for the support and feedback of the community. 🙏🏽 1/3

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@ayushnoori

Ayush Noori

7 months

Excited to deliver the next CCB Seminar at @harvardmed . Looking forward to sharing our ongoing work in @marinkazitnik 's lab on multimodal deep learning for drug repurposing and precision medicine. 🗓️ Date: Monday, October 30th 🕒 Time: 3PM ET 📍Location: @HMSCountway or Zoom

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Ayush Noori

2 months

Tour de force from @Emily_Alsentzer at @HarvardDBMI , who asks, “Can we leverage medical domain knowledge to produce more generalizable and scalable ML for healthcare?” I’m very excited about these research questions and Emily’s work to help answer them. 🙌🏽 1/2

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@zakkohane

Isaac Kohane

2 months

Genotypic and phenotypic external knowledge used to augment ML models for rare disease diagnosis: part 1 of talk by @Emily_Alsentzer @HarvardDBMI

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@ayushnoori

Ayush Noori

6 months

Huge congratulations to @benjamin0chang for a very well-deserved Rhodes Scholarship. 🎊 It’s been a true joy to launch @harvardopenbio with Ben, travel together to conferences like @SynBioBeta , and make new friends similarly passionate about biology @NucleateDojo . 1/2

@lizbwood

Elizabeth Wood 🧬🖥️🥼

6 months

A year ago or so, @KKajderowicz organized this great ML/bio mentor mentee matching program, and today I learned that my great mentee @benjamin0chang was elected as a Rhodes Scholar. Super cool!

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@ayushnoori

Ayush Noori

1 year

New Translation episode ft. @LindaBGoodman , co-founder and CTO at @faunabio , out now! Linda and I discuss the @ZoonomiaProject and her efforts to derive insights from extreme mammalian adaptations that may improve healthcare for humans. Learn more below! 👇🏽 1/14

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@ayushnoori

Ayush Noori

2 years

On @majoduran__ ’s recommendation, @ATrotmanGrant and I tried El Salvadoran pupusas today and were treated to a live mariachi performance. Cross-cultural exchange with friends is one of my favorite aspects of living in a vibrant, diverse city like #SanFrancisco .

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@ayushnoori

Ayush Noori

1 month

Kicking off the @harvardopenbio Future of Biology Conference with a keynote from @geochurch . 🧬 Thanks to all the in-person attendees and virtual registrants for an incredible turnout! Learn more about our conference at:

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@ayushnoori

Ayush Noori

1 month

Excited to invite all students to the @harvardopenbio Future of Biology Conference 2024! We are lucky to have an incredible speaker line-up, incl.: 🧬 - @geochurch ( @harvardmed ) 🌱 - @reshmapshetty ( @Ginkgo ) 🦾 - @DrRituRaman ( @MIT ) 🧫 - @jgooten + @omarabudayyeh ( @mcgovernmit )

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@ayushnoori

Ayush Noori

2 years

Recently tested out AlphaFold on @LatchBio 's platform. Verdict: streamlined, accessible UI with great in-built PDB visualization. Kudos to @AlfredoAndere and team!

@LatchBio

LatchBio

2 years

Alphafold predicts a protein's 3D structure from its amino acid sequence. Latch () now allows any scientist to run Alphafold with just a few clicks and view the 3D output right within the platform.

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@ayushnoori

Ayush Noori

2 years

Incredible bio community dinner by @pillar_vc and @DnaDeviants tonight in Kendall Square! Fitting conclusion to the summer and a celebration of the formidable life sciences ecosystem across Boston and Cambridge. 1/2

@DnaDeviants

DNA Deviants - #SynbioSundays! 🧬

2 years

We had an amazing time at the @DnaDeviants x @pillar_vc event tonight! Many thanks to the wonderful folks at @pillar_vc who put this together and huge thank you to everyone who came today to mingle and learn about founder led bio! 🧬

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@ayushnoori

Ayush Noori

12 days

Excited to share our perspective on empowering biomedical discovery with AI agents! 🤖 📖 Read the paper: 🧵 Learn more below!👇🏽

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Empowering Biomedical Discovery with AI Agents

We envision 'AI scientists' as systems capable of skeptical learning and reasoning that empower biomedical research through collaborative agents that integrate machine learning tools with...

@marinkazitnik

Marinka Zitnik

12 days

Empowering Biomedical Discovery with AI Agents 🤖 Long-standing ambition for biomedical AI is the development of AI systems that can make major scientific discoveries with the potential to be worthy of a Nobel Prize—fulfilling the Nobel Turing Challenge

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@ayushnoori

Ayush Noori

1 month

George speaking on gene and cell therapy approaches for large genetic payload delivery at the @harvardopenbio Future of Biology Conference. “This is really not that far off!” – @geochurch

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@ayushnoori

Ayush Noori

2 years

Incredible Day 1 of the @NucleateHQ Summit! Enjoyed finally meeting members of Nucleate’s global community in person and seeing 3D versions of 2D Zoom faces. 😁 Can’t wait for Day 2 at the @RoyaleBoston tomorrow!

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@ayushnoori

Ayush Noori

2 years

Hiking, crepes, horses, and a stunning sunset view of fog rolling into Silicon Valley with a few members of our Fifty 50 program at @fiftyyears . 1/3

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@ayushnoori

Ayush Noori

4 months

Love working out of the new @wyssinstitute space at 201 Brookline. Incredible concentration of life sciences talent who we share the building with (including, this week, @AlfredoAndere )!

@AlfredoAndere

Alfredo Andere

4 months

The concentration of cool biotechs in Boston is so incredible

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@ayushnoori

Ayush Noori

11 days

Thanks @ylecun for answering our questions on open source, AI regulation, biologically-inspired architectures, and biosecurity in the age of AI at @iclr_conf .

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@ayushnoori

Ayush Noori

2 years

Excited to share our new Translation episode ft. @LatchBio , which I co-hosted with @ATrotmanGrant . Enjoyed chatting with the brilliant Latch team @AlfredoAndere @kenbwork @kylegiff , who are working to bridge the divide between bioinformatics and biologists. 1/5

@fiftyyears

Fifty Years

2 years

New Translation episode out now! In this episode, we chat with @AlfredoAndere , @kenbwork , and @kylegiff – @UCBerkeley dropouts, computational prodigies, and co-founders of @LatchBio – about their mission to enable the #biocomputing revolution. 🎙️:

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@ayushnoori

Ayush Noori

11 months

Excited to share the final version of {metapaths}, the first #RStats software package to implement meta-paths and perform meta-path-based similarity search in heterogeneous KGs. Out now in Bioinformatics: Learn more below! 👇🏽 1/12

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Metapaths: similarity search in heterogeneous knowledge graphs via meta-paths

AbstractSummary. Heterogeneous knowledge graphs (KGs) have enabled the modeling of complex systems, from genetic interaction graphs and protein-protein int

academic.oup.com

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@ayushnoori

Ayush Noori

2 years

Highlight from last week: on Wednesday night, we co-hosted Brains & Bites with @E11BIO at @fiftyyears HQ, a community event to bring together scientists, entrepreneurs, and investors in the Bay Area passionate about neuroscience and neurotechnology. 1/6

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@ayushnoori

Ayush Noori

3 months

Fantastic to catch up with @_e_d_v_ . Blown away by the quality of his science, pace of his progress, and the dedication with which he pursues his mission. Headed back to Cambridge – until next time, SF!

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@ayushnoori

Ayush Noori

10 months

Thanks for a magical weekend, @joininteract . Fireside conversations with old and new friends about changing the world with technology. Especially grateful to the organizing team: @envisioningliz , @aivantg , @ansonyuu , and @winniethexu .

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@ayushnoori

Ayush Noori

6 months

I earnestly hope that this breakthrough is the harbinger of FDA-approved healthspan extension drugs. What an achievement, for @celinehalioua , for @loyalfordogs , and for the longevity field at large. 🐶 Towards a future of healthy aging and more time with our loved ones.

@celinehalioua

Celine Halioua

6 months

1 - Loyal has earned what we believe is the FDA’s first-ever formal acceptance that a drug can be developed + approved for lifespan extension 2 - We have 'technical section complete' AKA the 'does it work' data for LOY-001 - our large dog lifespan extension drug - is done

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@ayushnoori

Ayush Noori

2 years

Commemorating Valentine’s Day with my #oxytocin socks from @fiftyyears ! Elevated plasma oxytocin levels have been reported in romantic couples, and the neurotransmitter is involved in pair bonding and social selectivity.

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@ayushnoori

Ayush Noori

8 months

Alec is a busy person. He could have used his standard @AsimovBio deck. Instead, he prepped a presentation customized for the students in the @NucleateDojo x @harvardopenbio DojoExplore program. Thank you, @alectricity , for your genuine commitment to teaching and mentorship! 🙏🏽

@NucleateDojo

Nucleate Dojo

8 months

Huge thank you to @alectricity for joining us this week to kick off our Fall 2023 DojoExplore cohort at @harvardopenbio ! It's going to be an incredible 6 weeks for our student teams 🦠🧬💻

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@ayushnoori

Ayush Noori

6 months

Another phenomenal S³ biotech blackout episode. Love how @jasonjoyride captures the passion of the @LatchBio team. 🙌🏽 “What’s worth spending your life on?” – @kylegiff @AlfredoAndere , @kenbwork , and @kylegiff work hard and ship fast to build the software layer for biology.

@jasonjoyride

Jason Carman

6 months

Very soon, biological data will fly by all 120 zettabytes of the internet's data. What software will biology use for all of it? Enter @LatchBio for episode 17 of S³

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@ayushnoori

Ayush Noori

3 months

So excited for this new @KempnerInst seminar series on “all algorithmic + technological questions arising in the quest for efficient ML at scale.” Organized by the inimitable @schwarzjn_ and with a ⭐️-studded speaker line-up: - @sarahookr ( @CohereForAI ) ...more speakers in 🧵

@schwarzjn_

Jonathan Richard Schwarz

3 months

🚨 Excited to announce our new @Harvard seminar series on Efficient ML! Please join LLM superstars @sarahookr ( @cohere ) & @valentina__py ( @allen_ai ) for our kick-off meeting next Monday! Open to everyone! 📅 🔗 @harvard_data @harvardmed @KempnerInst

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@ayushnoori

Ayush Noori

1 year

Inspiring day celebrating cutting-edge advances in translational science across bioinspired therapeutics, diagnostics, biomaterials, cell engineering, and other domains of synthetic biology at the @wyssinstitute #WyssRetreat22 . 1/2

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@ayushnoori

Ayush Noori

2 years

With @ATrotmanGrant @majoduran__ @NandaPiyush at @BuiltWithBio and the @NucleateHQ after party. Equal parts phenomenal learning experience and inspiring convergence of the brightest minds in #synbio . 1/2

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Ayush Noori

2 years

The product of Xmas at @fiftyyears HQ with @sethbannon , @elamadej , and friends. Thanks for having me!

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Ayush Noori

6 months

Happy Diwali! Wishing light, love, and joy for you and your loved ones. 🪔

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Ayush Noori

3 months

This morning, I took a red-eye flight from Boston to @Stanford for @hackwithtrees 2024. Between the time the flight took off and the time we landed, the below happened. 🤯 Had much to catch up on once I turned my phone off airplane mode…

@PatrickJBlum

Patrick Blumenthal

3 months

wtaf is going on today

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Ayush Noori

2 years

New Translation episode ft. @dbgoodman out now! Dan shares the story behind his paper, "Pooled screening of CAR T cells identifies diverse immune signaling domains for next-generation immunotherapies," published today in @ScienceTM . Read on to learn more! 👇🏽 1/15

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Ayush Noori

29 days

The kids are alright… thanks to @noor_siddiqui_ and her team at @OrchidInc . Congratulations on these huge milestones and inspirational work, Noor.

@noor_siddiqui_

Noor Siddiqui

@noor_siddiqui_

29 days

SO INCREDIBLY PROUD to share 2 HUGE updates: 1) The first baby was born using @OrchidInc technology — and he’s super cute 🥰 2) I tested my own embryos with Orchid — we got SO much information & l feel confident now 🚀 This is the future of how babies will be born!

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Ayush Noori

2 years

Calling all Boston biocomputing folks! Hang and/or hack with the @LatchBio team (plus @NucleateHQ and @bitsinbio ) next week. If you’re a biologist who likes software, snacks, and swag, these are the events for you. RSVP below!👇🏽

@LatchBio

LatchBio

2 years

Two Boston events coming up next week. In collaboration with @NucleateHQ and @bitsinbio . Whether you prefer a casual meetup or an intense hack day, we would love to see you there! RSVP to hang: Apply to hack:

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Ayush Noori

7 months

The team at @FutureHouseSF led by @SGRodriques is poised to both envision and enable the future of scientific research and discovery, powered by AI. 🔮 Even more exciting that they’re structured as a non-profit research organization and backed by @ericschmidt . Congrats to all!

@SGRodriques

Sam Rodriques

7 months

Today, we are announcing Future House, a philanthropically-funded moonshot focused on building an AI Scientist. At Future House, our 10-year mission is to build semi-autonomous AIs for scientific research, to accelerate the pace of discovery and to provide world-wide access to

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Ayush Noori

1 year

I'm late - but blame @sethbannon for distracting me with good conversation. Check out the @fiftyyears mural at @SynBioBeta !

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Ayush Noori

6 months

These new GPTs to automate simple but tedious biomedical data preprocessing tasks make me feel like a kid in a 🍭 store.

@armish

B. Arman Aksoy

6 months

Would have been really convenient to have this companion GPT when I was doing my PhD 😭 Pathway figure -> gene list -> comp'al friendly format with basic annotations

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Ayush Noori

10 months

Fast grants have proven to be an important vehicle to accelerate scientific progress (e.g., during the pandemic). 🏃🏽 Few challenges are more deserving of this support than the climate. 🌎 Climate scientists, see below! 👇🏽 Kudos @sarakemppainen for spearheading this effort.

@fiftyyears

Fifty Years

10 months

1/ Solutions to the climate crisis are already here. But they're stuck in academic labs. Often, after the basic science is done, there’s just a little more work needed to show the science has commercial potential. But no one funds this! Introducing Manifest Climate!

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Ayush Noori

1 month

Crossing over the Charles River on Weeks Bridge this morning. Cambridge in the full of spring is a delight. 🌸 1/2

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Ayush Noori

2 years

Post- @fiftyyears offsite: feeling both grateful and hopeful about leveling up our founder support. We have work to do! 👊🏽

@sethbannon

Seth Bannon 🌻

2 years

Few things are as energizing as an all team offsite. So many inspiring ideas. Can't wait for you all to see what we have cooking at @fiftyyears !

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Ayush Noori

11 days

Come find @InakiArango and I at 11AM today in Hall A2 @gembioworkshop at @iclr_conf – we look forward to sharing our work with you! 👋🏽

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@ayushnoori

Ayush Noori

15 days

Excited to share our @gembioworkshop paper at @iclr_conf this week! We use multi-objective generative AI to design 26K+ small molecules predicted to be: - 🧠 Blood-brain-barrier permeable - 🎯 Dopamine receptor D2 binders - 💊 Safe and non-toxic - 🧪 Readily synthesizable 1/15

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Ayush Noori

3 months

@paultkim_ipd Perhaps b/c much of wet lab biology expertise is gained by practical experience rather than textbook knowledge? Lower barrier to entry to try your hand at dry lab research.

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Ayush Noori

2 years

Special thanks to @deboramarks , @chorye , @KKajderowicz and @janechuprin , @dj_mandell , @bkell1123 , @LSantollani , @H__Spinner , @MorseCell , the crew at @thedojohouse , and many more for the insightful conversations, and to @subaita_rahman for bringing us together. 🙏🏽 2/2

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Ayush Noori

1 year

Incredible new resource hot off the press for scientists who want to translate their academic discoveries to real-world solutions that help people! Visit to learn more.

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Spinout Playbook — Fifty Years

A guide to spinning out of academia

www.fiftyyears.com

@sethbannon

Seth Bannon 🌻

1 year

Introducing the Spinout Playbook, a free guide to spinning a startup out of academia. Why is this needed? The process of “spinning out” science from universities is broken 👇🧵

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Ayush Noori

1 year

As always, time with @subaita_rahman and @benjamin0chang is time well spent. 🥳

@subaita_rahman

Subaita Rahman

@subaita_rahman

1 year

biotech and ramen part 2

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Ayush Noori

3 years

Celebrated the new year with the publication of my first lead author paper, out now in Neurobiology of Disease! We performed a meta-analysis of 2600 human CNS transcriptomics samples to identify common pathways driving pathology across neurodegeneration.

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Ayush Noori

3 months

Wonderful new work from @drmichaellevin @DonIngber at the @wyssinstitute , led by colleagues @mmsperry @halehf . 🧊 Was fortunate to get a behind-the-scenes look at this project last year. Applications to organ transplantation, trauma management, space exploration, and more! 1/3

@drmichaellevin

Michael Levin

@drmichaellevin

3 months

New paper, awesome @wyssinstitute team: "Identification of pharmacological inducers of a reversible hypometabolic state for whole organ preservation" - biostasis!

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Ayush Noori

7 months

An accurate description of my friends based on our real conversation today. Mukundh: “When you said ASAP, I thought of…” @RikardSaqe : “ASAP Rocky?” @MukundhMurthy : “AsapSCIENCE?” Me: “Aligning Science Across Parkinson’s?” cc: @ASAP_Research @AsapSCIENCE

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Ayush Noori

2 months

Our @marinkazitnik lab team at the @HarvardCMSA 2024 Ding Shum lecture by @ylecun today. We missed getting a photo with the brilliant speaker himself – but maybe that’s another incentive to invite @ylecun back to Harvard again? 😁 1/4

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Ayush Noori

8 months

Many wonderful things to be said about the inauguration of @Harvard ’s 30th president, Claudine Gay, today. A moment I’d like to share: President Gay selected my friends on the Harvard #bhangra team to lead the recessional from Tercentenary Theater to Old Yard. 🎶 1/2

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Ayush Noori

2 months

Of all the April Fool’s jokes I’ve seen today, so glad this is not one of them. 🙌🏽

@itsandrewgao

Andrew Gao

2 months

FINALLY: a 3blue1brown video on Transformers

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Ayush Noori

9 months

Very much enjoyed @jure ’s talk on GEARS at the Joint @broadinstitute and @MITEECS Colloquium last February and excited to see how the work has advanced since the pre-print. Congrats, @yusufroohani @KexinHuang5 ! ⚙️

@jure

Jure Leskovec

9 months

📢 Exciting News! Our latest paper is now out in Nature Biotech 🌱🧬 We developed GEARS---an AI method to predict cellular responses to genetic perturbation. 🧪🔬 🔗 Link to the paper: 🧬 Unraveling genetic interactions in cancer, regenerative medicine,

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Ayush Noori

15 days

Excited to share our @gembioworkshop paper at @iclr_conf this week! We use multi-objective generative AI to design 26K+ small molecules predicted to be: - 🧠 Blood-brain-barrier permeable - 🎯 Dopamine receptor D2 binders - 💊 Safe and non-toxic - 🧪 Readily synthesizable 1/15

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Ayush Noori

3 years

Excited to share our latest research out now in @NatureAging which suggests that the #Alzheimer 's disease-linked #APOE e4 allele may prime #microglia towards a #phagocytic and #proinflammatory state in the normal aging #brain even before Alzheimer's pathology develops. (1/5)

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Ayush Noori

2 years

Among others, Andrew Turberfield and Erik Benson from @OxfordPhysics and @KavliOxford at @UniofOxford discussed the software-facilitated design and optimization of nanoscale DNA machinery, such as a DNA-based 2D molecular printer. See . 4/11

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A DNA molecular printer capable of programmable positioning and patterning in two dimensions

A nanoscale machine made from DNA moves under external control and prints by selectively modifying pixels on a canvas.

www.science.org

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Ayush Noori

11 days

“...including about 16,000 neurons, 32,000 glia, 8,000 blood vessel cells, and 150 million synapses.” @ScienceMagazine paper: Stunning images incl. those below: Huge congratulations to @stardazed0 and team! 2/2

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Ayush Noori

10 months

Summary of my summer: it’s been electric! Coding at @HMSCountway during the Boston thunderstorms: a bit of PyTorch @LightningAI and a bit of actual lightning! ⚡️ Today, I gave a lightning talk to @HarvardDBMI on my work in @marinkazitnik ’s lab as a SIBMI 2023 student. 1/11

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Ayush Noori

3 months

*SPECTRA-cular* work from @YEktefaie on evaluating generalizability of AI models for molecular datasets. 📊 Applied SPECTRA to 18 datasets from antibiotic resistance in TB to protein-ligand binding. 🔍 Tested 19 SOTA DL models, incl. LLMs, GNNs, diffusion models, and CNNs. 1/2

@YEktefaie

Yasha Ektefaie

3 months

It is no secret there exists a generalizability problem in AI for biology. Despite all the advances in ML methods, the way we evaluate generalizability in ML models has not changed. How well does your ML model generalize across the entire spectrum of possible dataset splits?

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Ayush Noori

2 years

Enjoyed the talks and panels featuring @srikosuri , @AlfredoAndere , @lexrovner , @jykishi , and other incredible speakers at the Founder-Led Biotech Summit hosted by @pillar_vc this week. Tune in today for Day 4! #founderledbio

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Ayush Noori

7 months

Enjoyed catching up with old and new friends – like @TVKamath , @jykishi , @ATrotmanGrant , @Bangulo89 – at the Founder-led Biotech Tour in Boston tonight. 🥂 Incredible turnout. Thanks to @kulesatony , @titanioustom , @madelynheart_ , and team at @pillar_vc for bringing us together.

@kulesatony

Tony Kulesa

7 months

📢 The 2023 Founder-led Biotech Tour In November, we're teaming up with 50+ founders to bring the community together in four cities. SF: 11/2 Boston: 11/7 NYC: 11/9 London: 11/13 + virtual events including co-founder matching, speed networking, and more.

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Ayush Noori

7 months

Late night fireside chat with the inimitable @LauraDeming and @AlexJColville about: - 😴 human hibernation, - ⚖️ health equity, and - 💊 working towards FDA approval of the first longevity intervention to extend the human healthspan. cc: @time_initiative @AFARorg @age1vc

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Ayush Noori

7 months

“When they’re not turning pumpkins into boats, @harvardopenbio ’s activities include hosting educational workshops, providing mentorship opportunities, and providing space and resources for student-led research projects.” @benjamin0chang ’s 🎃 voyage will go down in OpenBio lore!

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@MCB_Harvard

MCB_Harvard

7 months

CPB Concentrator Benjamin Chang (‘24) Crosses the Charles River…in a Pumpkin @RachelleGaudet @denic_lab @AdamEzraCohen @izzymgm @Harvard

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Ayush Noori

1 year

Excited to moderate a panel discussion at the 2023 @SynBioBeta Conference on community building in #biotech 🧬 to empower students, founders, and investors. 1/4

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Ayush Noori

1 year

The formidable @jennifertsai_ and the team at @NucleateDojo are working to fill a massive unmet need and democratize access to student-led science research. Please share with motivated and passionate undergraduate researchers!

@NucleateDojo

Nucleate Dojo

1 year

Undergrad researchers are full of potential, but are often unpaid or underpaid. We're launching an institution-agnostic grants program to enable ANY undergrad to pursue life science research. If you're interested in sponsoring grants for future biotech innovators, shoot us a DM!

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Ayush Noori

1 year

Happy to share our framework for multimodal graph learning, out now in @NatMachIntell . Available at , tweetorials below. 1/2

@marinkazitnik

Marinka Zitnik

1 year

Excited to share the blueprint for multimodal graph learning in @NatMachIntell We envision graph AI playing a key role in future image-intensive, knowledge-grounded, and language-intensive systems 1/5

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Ayush Noori

1 year

I'm thrilled about the tools and resources that @fiftyyears is making available to support scientists who seek to become world-class entrepreneurs. Building these support systems will help founders rapidly move discoveries from the bench to the bedside. 1/5

@sethbannon

Seth Bannon 🌻

1 year

A VC that builds? To best support founders, VCs can't run like law firms. They need to run like the startups they back. They need to build. We're excited to show you some of the things we've been building at @fiftyyears . 1/

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Ayush Noori

2 years

It’s always exciting to put savvy and impact-oriented people in the same room, especially when we’re young (and optimistic)! @serena2z and I loved jamming with @MukundhMurthy and @alishbaimran_ at @fiftyyears HQ.

@alishbaimran_

Alishba Imran

2 years

Had fun visiting the @fiftyyears HQ and meeting friends!

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Ayush Noori

1 month

Natural self-assembling protein Sierpiński fractals?! This is crazy. Awesome figure from by @SendkerFL @KaHochberg in @Nature showing cryoEM structures of the 0th-order 6mer, 1st-order 18mer, and 2nd-order 54mer.

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@SendkerFL

Franziska Sendker

1 month

Happy and super excited to share our discovery of a protein fractal! We unravel the surprisingly simple emergence of these marvellous structures and show it might have even been an accident of evolution. Read the full story here Or just stick around 🧵

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Ayush Noori

2 years

Happening now via @dnatieclub !

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Precise genome editing w/ retrain-derived DNA!

With Santi Lopez, Will Barr and 2 others

www.clubhouse.com

@katclone

Kat

2 years

Join us Sunday @ 4 PM EST for a #SynBio @DnaDeviants Journal Club w/ 1st author @oso_de_antojos from @seth_shipman 's lab @GladstoneInst ! Event will be moderated by MIT Bio PhD student @will_barrcode via @dnatieclub !🧬

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Ayush Noori

2 years

For those of us who have a family history of neurodegeneration, the possibility of future dementia can be terrifying. @sarakemppainen is fighting back by diving into the literature. Check out her great thread below! 👇🏽 1/9

@sarakemppainen

Sara Kemppainen

@sarakemppainen

2 years

1/13 I’m scared of losing my mind. Not in the literal sense, but in the sense of diminished memory and thinking capability. And my fear is not completely unreasonable: numerous women in my family have been diagnosed with Alzheimer’s disease. But it isn't just my family. 🧵

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Ayush Noori

2 years

The 10,000x increase in data output from the wet lab over the past 10 years necessitates new tools for analysis. As the AWS x GitHub of biocomputing, the @LatchBio end-to-end platform is poised to accelerate the pace of scientific discovery to reveal new biological insights. 2/5

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