Patrick Hsu @pdhsu Twitter profile

Pinned Tweet

Patrick Hsu

4 months

By the way, our lab is recruiting across experimental and computational roles (scientists, postdocs, RAs) so if you're excited by the bridge RNA discovery and the potential for genome design, please contact me!

Patrick Hsu

@pdhsu

4 months

Just shared at @KeystoneSymp a new @ArcInstitute discovery of the bridge RNA recombinase mechanism: a new class of natural RNA-guided systems that retains the key property of programmability from RNAi and CRISPR while enabling large-scale genome design beyond RNA and DNA cuts

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Patrick Hsu

@pdhsu

1 year

imagine a ChatGPT browser extension that reads the Terms and Conditions agreement and flags anything that is non-standard

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Patrick Hsu

@pdhsu

5 months

I was homeschooled until college. To show I was academically prepared in my apps, I took 8 AP exams—the max I could schedule and register for. Went to the bookstore and bought 2 prep books per exam, read all 16 cover to cover over 2 months. That was my American high school

Chrisman

@chrismanfrank

5 months

When friends start homeschooling they are invariably shocked at how little time is needed for academics. School just fills the time.

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Patrick Hsu

@pdhsu

3 years

Assistant Professor Daniel Craig after another week of grant deadlines, re-learning the chi^2 test, and reading 40 abstracts but 0 papers. He loves his job, students, and cold brew coffee.

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Patrick Hsu

@pdhsu

9 months

scientist after sequencing lots of single cells

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Patrick Hsu

@pdhsu

3 months

Is DNA all you need? In new work, we report Evo, a genomic foundation model that learns across the fundamental languages of biology: DNA, RNA, and proteins. Evo is capable of both prediction tasks and generative design, from molecular to whole genome scale.

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Patrick Hsu

@pdhsu

8 months

Just got my green card and used Global Entry for the first time. 2 sec interaction after the kiosk: “Mr. Hsu, anything to declare? No? Welcome home!” I didn’t realize how much this could mean to me. And what it still feels like to be an immigrant even after so many years here

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Patrick Hsu

@pdhsu

2 years

Delighted to announce the Arc Institute @arcinstitute , a new, independent scientific institution dedicated to the study of complex human disease. Working with our partners @UCBerkeley @Stanford @UCSF , our mission is to accelerate progress in biomedical research and therapeutics.

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Patrick Hsu

@pdhsu

4 months

Just shared at @KeystoneSymp a new @ArcInstitute discovery of the bridge RNA recombinase mechanism: a new class of natural RNA-guided systems that retains the key property of programmability from RNAi and CRISPR while enabling large-scale genome design beyond RNA and DNA cuts

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Patrick Hsu

@pdhsu

3 years

Ever wondered where your tail went? Transposons are to blame 🙉

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Patrick Hsu

@pdhsu

2 years

TikTok is hiring a computational chemist to "speed up classical molecular dynamics and quantum chemistry algorithms with artificial intelligence and high-throughput computational methods"🤯

Research Scientist in Computational Chemistry (Scientific Computing)- 2023 Start (PhD) - TikTok...

View our opening for Research Scientist in Computational Chemistry (Scientific Computing)- 2023 Start (PhD) and learn more about what it's like to work at TikTok.

careers.tiktok.com

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Patrick Hsu

@pdhsu

1 year

This can be generalized to other common documents like one or two-way CDAs, modified SAFEs, leases, warranties, etc. @DocuSign should build this

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Patrick Hsu

@pdhsu

3 years

The ability of molecular biologists to control DNA has relied on enzymes derived from the phage-microbe arms race. In this new work, we systematically mined thousands of new serine integrases (LSRs) and developed them for human genome editing. 🧬

Large-scale discovery of recombinases for integrating DNA into the human genome

Recent microbial genome sequencing efforts have revealed a vast reservoir of mobile genetic elements containing integrases that could be useful genome engineering tools. Large serine recombinases...

www.biorxiv.org

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Patrick Hsu

@pdhsu

6 months

The first approved CRISPR medicine in the world for sickle cell disease and beta thalassemia! A huge victory for biotechnology, patients, and humanity

Vertex and CRISPR Therapeutics Announce Authorization of the First CRISPR/Cas9 Gene-Edited...

Vertex Pharmaceuticals Incorporated (Nasdaq: VRTX) and CRISPR Therapeutics (Nasdaq: CRSP) announced today that the United Kingdom (U.K.) Medicines and

www.businesswire.com

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Patrick Hsu

@pdhsu

6 months

I went to a dinner last night where half of my table left at 830 to go back to work. It made me optimistic about the future. Accelerate!

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Patrick Hsu

@pdhsu

2 years

Delighted to try out the world’s first CRISPR-edited salad from Conscious Foods and @PairwisePL . Mustard greens were edited with Cpf1/Cas12a to reduce their spiciness while retaining their nutritional content (which is 2X better than romaine lettuce). 🙏 @zhangf for the invite

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Patrick Hsu

@pdhsu

1 year

At @ArcInstitute , we're launching the Arc Science Fellows program for early-career scientists to start their own lab right after grad school with $250K/year research budget + salary. I'm running an info session next Fri (Dec 16 at 1pm PT)! Sign up here:

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Patrick Hsu

@pdhsu

2 years

How can I replicate my productivity on an airplane in my normal office?!

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Patrick Hsu

@pdhsu

4 months

In an era of RNA delivery and therapeutics, we sought to “write” RNA molecules directly into messenger RNA to replace disease-causing exons or engineer synthetic proteins Our new work on RESPLICE enables fully programmable and highly efficient (45-90%) transcriptome engineering

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Patrick Hsu

@pdhsu

4 years

Hot take - biology is the only one with truly difficult ideas. That’s why everyone is trying to apply math, physics, ML, etc to understand biological principles and behavior

Michael Levin

@drmichaellevin

4 years

Does biology have truly difficult ideas? Studying math, comp sci, physics, etc., one quickly encounters material that is hard to truly grasp (and many of us get to a point where we mentally just can't go further, while some others can). Does this exist in biology? If not, why?

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Patrick Hsu

@pdhsu

5 months

in another life I would have really liked just editing genomes and training foundation models with you

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Patrick Hsu

@pdhsu

5 years

I don't normally do this but can't resist sharing this email I recently got: "“Respected Sir, I am writing to express my keen interest in your lab, where I can utilize my experience in cut-throat scientific research.”

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Patrick Hsu

@pdhsu

5 years

Excited to announce that my lab is moving this fall to @BerkeleyBioE . We develop new biotechnologies (and not just CRISPR-Cas!) to control brain and immune cell function for improving human health. Hiring at all levels (postdocs, grad students, RAs) -

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Patrick Hsu

@pdhsu

4 years

The best coronavirus/SARS-CoV-2 biology lecture I have seen so far, by Britt Glaunsinger @UCBerkeley @berkeleyMCB @HHMINEWS @igisci . Covers where it comes from, how it gets into the cell, replicates in the host, and exploits the immune system against you.

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Patrick Hsu

@pdhsu

6 months

It takes too long to start your own lab—the average R01 recipient is 42 y/o 😵. Want to start your independent research group out of grad school? Come to my @ArcInstitute Fellows Program info session next Wed (Nov 15, 12pm PT). You'll get a $250K/year research budget + salary.

Arc Institute

@arcinstitute

6 months

At Arc, we give early career scientists a springboard for launching their independent careers through our Science Fellow program. Learn more at our virtual information session next Wednesday, Nov. 15, from 12-1pm PST, hosted by Arc co-founder & Core Investigator @pdhsu . 👇

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Patrick Hsu

@pdhsu

3 years

Mammalian cells have a native RT, which participated in RNA-templated DNA repair!

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Patrick Hsu

@pdhsu

4 months

We would love to do this! Any SWEs interested in biology x AI research, please reach out

Samarth Jajoo

@jajoosam

4 months

Arc should create a OpenAI residency type program where they take in software engineers and let them rotate between labs. SWEs get to work on problems in biology + lab productivity almost certainly increases. Eventually creates an incredible hacker culture in the institute!

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Patrick Hsu

@pdhsu

3 years

Paul Nurse, who won a Nobel for his work on the cell cycle, calls for more daring theory in biology and criticizes current trends in large scale data generation. We probably need to reimagine the Discussion section of papers!

Biology must generate ideas as well as data

Nature - Data should be a means to knowledge, not an end in themselves.

www.nature.com

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Patrick Hsu

@pdhsu

9 months

RNA as a message RNA as a catalyst RNA as a regulator RNA as a medicine ...what's next?

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Patrick Hsu

@pdhsu

3 years

Tour de force engineering @Nature by @jgooten @omarabudayyeh discovering Cas7-11 as a collateral-free RNA targeting tool. Also a beautiful story of CRISPR evolutionary biology blurring the lines of multi-subunit and single effector defense systems

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Patrick Hsu

@pdhsu

1 year

Making progress on the new @arcinstitute headquarters 👷👷‍♀️🧬

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Patrick Hsu

@pdhsu

3 years

Why does it seem that theory in biology is much less respected or established than in other fields, such as physics?

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Patrick Hsu

@pdhsu

4 months

There is no shortcut to the struggle. More senior researchers went through the exact same journey. The most valuable class I ever took was an epigenetics class where we had to deep-read the primary literature. I had a special highlighter for words or methods I didn’t understand

Suhail

@Suhail

4 months

I was thinking about Karpathy's "only compare yourself to younger you" and how I found reading AI research papers intimidating in 2022 because I didn't understand the terminology + math symbols. It really just takes practice reading 100s and then suddenly it's no big deal.

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Patrick Hsu

@pdhsu

2 years

It was so fun to discuss the future of biotech with the Mayor of Miami @FrancisSuarez and @omarabudayyeh

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Patrick Hsu

@pdhsu

4 years

Happy to share our huge collaborative effort @UCBerkeley @UCSF to systematically evaluate coronavirus antibody tests. We'll be updating with new data at - 10 lateral flow assays and 2 ELISAs so far. Read more @nytimes :

Coronavirus Antibody Tests: Can You Trust the Results? (Published 2020)

A team of scientists worked around the clock to evaluate 14 antibody tests. A few worked as advertised. Most did not.

www.nytimes.com

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Patrick Hsu

@pdhsu

3 years

Embryogenesis up to E11 in 3D roller bottles @nature . The supplementary videos are insane. And check out the in utero vs ex utero UMAP 🤯

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Patrick Hsu

@pdhsu

2 years

Great to have our study out in @NatureBiotech today! >50% knock-in of multi-kilobase DNA payloads into the human genome for functional genomics, synthetic biology, and future therapeutics

Nature Biotechnology

@NatureBiotech

2 years

Systematic discovery of recombinases for efficient integration of large DNA sequences into the human genome

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Patrick Hsu

@pdhsu

2 years

He turned DNA sequencers into a biological time machine. Growing up, I eagerly read Svante’s work in Popular Science and first met him in 2016 shortly after starting my lab. His zest for life and humorous curiosity really stood out. Neanderthal Man is a highly recommended read!

The Nobel Prize

@NobelPrize

2 years

BREAKING NEWS: The 2022 #NobelPrize in Physiology or Medicine has been awarded to Svante Pääbo “for his discoveries concerning the genomes of extinct hominins and human evolution.”

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Patrick Hsu

@pdhsu

4 months

It’s an exciting time to work at the intersection of biology and AI across the spectrum from pure atoms to pure bits Historic opportunities in our lifetime for synthetic biology, body/brain-computer interfaces, and robotics

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Patrick Hsu

@pdhsu

2 years

Building @arcinstitute ! Can’t wait for this to be full of scientists

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Patrick Hsu

@pdhsu

3 years

In this new work with @SKonermann 's lab, we developed a Cas13 platform for high-throughput phenotypic screening and, using deep learning, elucidated the design principles underpinning its RNA targeting efficiency across ~130,000 guide RNAs tiling 55 essential gene targets.

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Patrick Hsu

@pdhsu

4 months

also underappreciated: reading actual textbooks long after you’ve left formal school I have a whole spiel about the chasm that is adult learning. Remarkably few people continue to digest structured or didactic content when they don’t “have” to

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Patrick Hsu

@pdhsu

10 months

The most impactful near-term thing we can do in science publishing to improve research culture is to prominently credit and display co-first authors. It should be immediately clear. Right now, readers have to click on author contributions or decode weird superscript symbols 👇

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Patrick Hsu

@pdhsu

10 months

Damn I love coming to lab. So much building to do @arcinstitute

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Patrick Hsu

@pdhsu

1 year

Making exciting progress on our @arcinstitute labs!

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Patrick Hsu

@pdhsu

5 months

Thank you Barron’s test prep! You guys had the best stuff 🙏

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Patrick Hsu

@pdhsu

2 months

here’s the CEO of @cognition_labs while you were partying, he was studying the blade

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Patrick Hsu

@pdhsu

2 years

🚨 We are hiring 2-3 more faculty @arcinstitute to join our current team of 4 Arc Core Investigators, who also hold faculty appointments at our partner universities @Stanford @UCBerkeley @UCSF . Your lab at Arc HQ will be fully funded for up to 20 people

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Patrick Hsu

@pdhsu

3 months

It was an honor to host PG and other friends of Arc today for a sneak peek of some of our latest, unpublished discoveries It's a crazy time to work at the interface of biology and AI. Come join us!

Paul Graham

@paulg

3 months

I went to visit Arc Institute and it was one of the most impressive things I've ever seen. They only just started and they've already made multiple big discoveries. I can't imagine a more impactful organization you could donate to.

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Patrick Hsu

@pdhsu

2 months

It’s early days @arcinstitute but we will do our best! We’ve grown to over 150 people and have many roles that we’re continually opening on a rolling basis Current goals are to model a virtual cell, create a new life form, and develop rational ways to target Alzheimer’s disease

Paul Graham

@paulg

2 months

They're too modest. I'll put it plainly: If you want to work for the Bell Labs or Xerox Parc of your time, this is it.

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Patrick Hsu

@pdhsu

3 years

Today on @biorxivpreprint , we combine genome-scale CRISPR activation and knockout screening to elucidate the functional landscape of SARS-CoV-2 host factors in human lung epithelial cells and systematically define their proviral and antiviral roles.

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Patrick Hsu

@pdhsu

1 year

The 3D model of CRISPR-Cas13d, which we discovered with @SKonermann , is featured in the @MIT Science Museum alongside Cas9 and Cas12a. Pretty cool!

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Patrick Hsu

@pdhsu

2 years

Bob Langer wasn't always one of the most famous scientists. His first 9 grant apps were rejected. No chemical engineering department in the country would hire him as faculty, so he started out in the Nutrition dept at MIT. An energizing interview:

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Patrick Hsu

@pdhsu

6 months

🧵 of insanely overlooked places to eat in SF: yongzi ji for amazingly authentic HK-style wonton noodle soup. less than 10 things on the menu so you know it’s good. a hole in the wall run by an impossibly sweet older couple pro-tip: add ~3:1 vinegar:soy sauce to taste

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Patrick Hsu

@pdhsu

5 months

RNA targeting has vexed the field of programmable biology for 20 years since the Nobel-winning discoveries of RNA interference and CRISPR In this new work with @SKonermann , we attack the problem with AI and data scale, enabled by massive screens and mechanistic interpretability

Arc Institute

@arcinstitute

5 months

🧬New paper + tool out of @pdhsu @skonermann Labs, led by @StanfordBioE Ph.D. student @JingyiWei4 : a new RNA targeting CRISPR enzyme paired with a convolutional neural network (CNN) model predicting highly efficient guide RNA sequences for transcriptome engineering.

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Patrick Hsu

@pdhsu

1 year

@theDailyBrag1 Seems like a core feature

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Patrick Hsu

@pdhsu

1 month

the scientist that inspires me every day. it was wonderful to host @zhangf here at @arcinstitute I miss our 1am minipreps

Feng Zhang

@zhangf

1 month

Inspiring visit at the @arcinstitute today with @pdhsu & @SKonermann . Thoughtful vision, exciting science, and amazing potential.

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Patrick Hsu

@pdhsu

5 months

by the way, 50% of @arcinstitute faculty were homeschooled and all 3 arc founders did high school science fair

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Patrick Hsu

@pdhsu

2 years

Basic science is not at odds with industry science and I don’t understand why they are perceived as competing verticals. Going to industry after my PhD made me a better scientist. We just need to make sure the flow of talent is bidirectional

Sri Kosuri

@srikosuri

2 years

You can't simultaneously say there are so many talented people so we need to add more positions and up paylines, and at the same time say academia will be decimated because some percentage of people are leaving. 4/6

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Patrick Hsu

@pdhsu

4 months

Can confirm it’s super exciting to go to lab every day! If we can emulate even some of the magic of early YC, we will be very lucky

Paul Graham

@paulg

4 months

Reading progress reports from @arcinstitute is inspiring. They get so much done so fast. They're like a startup of research. It must be very exciting to work there.

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Patrick Hsu

@pdhsu

2 years

So fun to learn from @BarackObama about leading a 3M person organization, 51/49 decisions, and the things people don’t realize about the Situation Room. Thanks so much @fdesouza , for the invite!

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Patrick Hsu

@pdhsu

5 months

sometimes I miss boston but a visit quickly cures me

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Patrick Hsu

@pdhsu

4 years

Zoom interview tips for faculty job market: 1. Clearly link your past research to future vision - spell out your trajectory 2. Understand the dept and goals of the search. Research fit is key 3. How would you amplify your colleagues? 4. You are the expert. Own your work :)

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Patrick Hsu

@pdhsu

1 year

New @arcinstitute building wouldn’t be complete without a new sequencer, and luckily our @illumina Novaseq X Plus just arrived. Thanks @fdesouza for inviting us to be launch partners! We’re now ready to sequence everything @arcinstitute

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Patrick Hsu

@pdhsu

1 year

"Science saves lives" - sure, but what are the numbers? This analysis of randomized phase III trials estimates that the (ongoing) war on cancer has generated 14.2 million life-years for cancer patients on a federal investment of $326 per life-year!

Population, Clinical, and Scientific Impact of National Cancer Institute's National Clinical Trials...

PURPOSE In the United States, the National Cancer Institute National Cancer Clinical Trials Network (NCTN) groups have conducted publicly funded oncology research for 50 years. The combined impact of...

ascopubs.org

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Patrick Hsu

@pdhsu

3 months

Herb Boyer was 37 years old in 1973 when he reported, along with Stanley Cohen, the construction of recombinant DNA plasmids for the first time That work was done right here in the Bay, in a UCSF-Stanford collaboration. How do we reactivate our history of great technical depth?

Dwarkesh Patel

@dwarkesh_sp

3 months

"I wonder for people in their 20s if they shouldn't go to San Francisco. The entrepreneurs are held in excessively high regard in my view. I think that San Francisco doesn't really encourage the pursuit of really deep technical depth." - @patrickc Full episode out tomorrow

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Patrick Hsu

@pdhsu

4 years

German study on viral load kinetics and seroconversion timescale, out in @nature . Highlights huge time sensitivity of swab testing, viral loads in upper respiratory tract tank after ~5 days of symptoms (swabs are yellow line, orange is sputum).

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Patrick Hsu

@pdhsu

2 months

More ML advances from @arcinstitute 🔥 @genophoria 's lab reports in @CellGenomics a machine learning model that predicts RNA secretion. This will enable cool applications in noninvasive diagnostics and synthetic biology!

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Patrick Hsu

@pdhsu

3 years

1 year into COVID I almost miss the SF parties when guys would mansplain CRISPR to me

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Patrick Hsu

@pdhsu

3 months

Are you interested in designing DNA and visualizing the generated protein? Our team member @ai_with_brains just put Evo, our DNA foundation model, into a simple colab notebook so you can interact with evolution in a browser :)

hello_evo.ipynb

Run, share, and edit Python notebooks

colab.research.google.com

Patrick Hsu

@pdhsu

3 months

Is DNA all you need? In new work, we report Evo, a genomic foundation model that learns across the fundamental languages of biology: DNA, RNA, and proteins. Evo is capable of both prediction tasks and generative design, from molecular to whole genome scale.

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Patrick Hsu

@pdhsu

1 year

Prediction: anti-aging drug development is going to hard-pivot into obesity/metabolism drugs. Semaglutide is just the first beachhead to make a big dent in healthspan for the overweight.

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Patrick Hsu

@pdhsu

2 years

The importance of practicing having fun is extremely underrated. Have fun at work too! Science is hard enough and it’s way too easy to forget how cool it is that we get to build the future

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Patrick Hsu

@pdhsu

5 years

Awesome to see a new Science paper from Stanley Qi at Stanford using our Cas13d system for RNA live FISH! Hundreds of labs have our plasmids, you can get them on @Addgene :)

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Patrick Hsu

@pdhsu

1 year

Where it started and how it’s going @arcinstitute

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Patrick Hsu

@pdhsu

4 years

Exciting! 1. No humoral responses to Cas9 detected, 2. Chromosomal translocations with triple KO detected but decreases over time (no apparent growth adv), 3. Long term engraftment - avg half life of T cells is 84 days vs 1 wk with previous engineered NYESO T cells

Science Magazine

@ScienceMagazine

4 years

Following the first U.S. test of #CRISPR gene editing in patients with advanced cancer, researchers report findings in Science that represent an important step toward the ultimate goal of using gene editing to help a patient’s immune system attack cancer.

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Patrick Hsu

@pdhsu

5 months

Congratulations to incoming Arc Science Fellow @zhou_jingtian for leading a landmark study in @Nature illuminating the epigenomic landscape of brain-wide projection neurons! We are excited to have Jingtian join us next month @arcinstitute !

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Patrick Hsu

@pdhsu

3 years

One of the key problems in discovery science is the lack of attractive, long-term career options for staff scientists. In tech, "staff software engineer" is a highly respected position that recognizes exceptional individual contributors. I have several ideas to solve this.

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Patrick Hsu

@pdhsu

4 months

this is what research feels like

trevy

@chillextremist

4 months

Imagine being a sheep venturing alone into the fog of war

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Patrick Hsu

@pdhsu

4 years

I'm really inspired by our efforts @UCBerkeley @UCSF @igisci to fight COVID-19. So many incredible scientists putting our heads together. Here's how we are trying to help: My lab is hiring for this - if you're interested in helping out, DM or email me

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Patrick Hsu

@pdhsu

4 months

RNAs have been historically very challenging to drug. @arcinstitute and @ucsf investigator Hani Goodarzi @genophoria reports an AI framework for targeting microRNAs with small molecules (with implications for breast cancer and RNA drivers of other diseases) Arc loves AI and RNA!

Eric Topol

@EricTopol

4 months

How do you go from 9 million molecules to 8 which appear effective against a micro RNA driver of breast cancer? Like this @Patterns_CP #AI @genophoria @UCSF @UCSFCancer

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Patrick Hsu

@pdhsu

1 year

Great News and Views in @NatureBiotech by @shsternberg on our recent paper discovering next-gen serine integrases for large-scale human genome editing, plus complementary work from @jgooten @omarabudayyeh @davidrliu combining them with prime editing

Novel recombinases for large DNA insertions

Nature Biotechnology - Bioinformatic mining and engineering of serine recombinases yields improved genome editing tools.

www.nature.com

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Patrick Hsu

@pdhsu

3 years

On a $50M experiment in rapid science funding during COVID-19 and what surprised us, with @patrickc and @tylercowen . Now in @a16z Future:

What We Learned Doing Fast Grants

We launched an abnormally fast source of emergency science funding during COVID-19. The results revealed flaws in current science funding models.

future.com

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Patrick Hsu

@pdhsu

2 years

It’s Monday @arcinstitute ! The new Arc HQ will open in Spring 2023 and house @Stanford @UCBerkeley @UCSF faculty and graduate students, as well as institute scientists, postdocs, and operational staff

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Patrick Hsu

@pdhsu

5 months

Arc is building at the intersection of biology and AI. This requires high throughput systems for model output validation and interpretation, not just more data for model training Most importantly, we need all of these experimental and computational capabilities under one roof

Angelos Georgakis

@angelosgeo

5 months

Seems like tech is in love... 🧬💘 "Where do I think the next amazing revolution is going to come? And this is going to be flat-out one of the biggest ones ever. There's no question that digital biology is going to be it." — Jensen Huang, CEO of Nvidia "Biology is the next big

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Patrick Hsu

@pdhsu

4 months

Big day for us at Arc! We grew today by over 20 amazing scientists 😇 Welcome to Hani, Jingtian, and their labs!

Arc Institute

@arcinstitute

4 months

☀️It’s a great week at Arc as we welcome our new Core Investigator @genophoria and his lab, and our first Science Fellow @zhou_jingtian ! We’re proud to add these talented minds to our ranks, bringing with them a multidisciplinary approach to human disease research. Welcome, all!

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Patrick Hsu

@pdhsu

6 months

Over 500 applications for our @arcinstitute faculty searches, in partnership with the Pathology, Data Science, and Genetics departments @stanford ! 🔥

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Patrick Hsu

@pdhsu

2 years

Basic science has never been more important. To advance biology beyond a largely descriptive discipline to an engineering field, we are going to require several biotechnological revolutions. This arc will take us beyond single genes and cells to characterize systems behavior

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Patrick Hsu

@pdhsu

4 months

It’s basically standard for tech company startups to have cofounders that complement and lift each other, yet actively discouraged in academic lab startups It gets worse: in many departments, co-senior authored papers don’t even count for tenure This should change

Itai Yanai 💔

@ItaiYanai

4 months

Had a potentially life-changing experience yesterday listening to a talk by @BobFarese and @TobiWalther and realizing the benefits of having the kind a scientific partnership that comes with having a joint lab. I’m thinking now that I would really love to do that!

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Patrick Hsu

@pdhsu

2 years

explaining why your paper is cool in the cover letter for the editor

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Patrick Hsu

@pdhsu

1 year

Who's doing the most exciting work in protein sequencing?

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Patrick Hsu

@pdhsu

10 months

my current read. what an amazing scientist. she literally just spent years vibing with corn and studying their patterns to discover the most fundamental mechanism of genetic diversity

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Patrick Hsu

@pdhsu

6 months

enjoyed spending a few days exploring the latest in AI with friends and experts in LLMs, material science, chips, compute, biology, national security, and policy thanks @natfriedman and @alexandr_wang

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Patrick Hsu

@pdhsu

3 years

Principles of biological computing @Nature - thin RecA filaments stretch throughout the cell, allow fast search for sequence homology in bacterial genomes by reducing dimensionality. Conceptually similar to hash tables

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Patrick Hsu

@pdhsu

3 years

After receiving her CRISPR therapy for her genetic form of degenerative blindness, one patient dyed her hair green - her favorite color, because "I can see them a lot more brilliantly now. It's just amazing" Congratulations to everyone @editasmed .

🔊 Listen Now: Gene-Editing Experiment Improves Sight In Patients With Impaired Vision

Morning Edition on NPR One | 3:52

one.npr.org

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Patrick Hsu

@pdhsu

7 months

excited he’s moving back to SF @zebulgar

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Patrick Hsu

@pdhsu

3 years

First week of classes and the undergrads still hand me flyers 😇

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Patrick Hsu

@pdhsu

3 years

Great article in @NatRevDrugDisc on the clinical landscape of AAV gene therapies with discussion of capsid, promoter, and safety trends.

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Patrick Hsu

@pdhsu

4 months

ooh i think my dad walked this road on his way to school every day

Latest in space

@latestinspace

1 year

This is the world’s longest continuous road that a person can walk on 🌍

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Patrick Hsu

@pdhsu

2 months

crazy to me that a substantial fraction of the population has replaced milk with seed oil emulsions

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Patrick Hsu

@pdhsu

3 years

Renato Dulbecco of DMEM fame spent most of his career @salkinstitute . When my lab was there, we would purify CRISPR proteins in the cold room using his lab's rusty old column chromatography stands (they were all labeled with his name). I almost took one home...

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