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Nature Biotechnology

@NatureBiotech

4 years

CRISPR–Cas12-based detection of SARS-CoV-2

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Nature Biotechnology

@NatureBiotech

3 years

Bioorthogonal information storage in L-DNA with a high-fidelity mirror-image Pfu DNA polymerase

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Nature Biotechnology

@NatureBiotech

3 years

Fully implantable and bioresorbable cardiac pacemakers without leads or batteries

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Nature Biotechnology

@NatureBiotech

3 years

The Organoid Cell Atlas

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Nature Biotechnology

@NatureBiotech

3 years

A genomic catalog of Earth’s microbiomes

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Nature Biotechnology

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2 years

Scalable in situ single-cell profiling by electrophoretic capture of mRNA using EEL FISH

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Nature Biotechnology

@NatureBiotech

2 months

AlphaFold2 and RoseTTAFold are limited to predicting the 3D structure of proteins. A new all-atom method models complete biomolecular assemblies, including proteins, nucleic acids, small molecules, metals, and covalent modifications. #NBThighlight

Generalized biomolecular modeling and design with RoseTTAFold All-Atom

Deep-learning methods have revolutionized protein structure prediction and design but are presently limited to protein-only systems. We describe RoseTTAFold All-Atom (RFAA), which combines a residu...

www.science.org

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Nature Biotechnology

@NatureBiotech

7 months

The chemistry of next-generation sequencing

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Nature Biotechnology

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1 year

Drag-and-drop genome insertion of large sequences without double-strand DNA cleavage using CRISPR-directed integrases

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Nature Biotechnology

@NatureBiotech

3 years

A Python-based programming language for high-performance computational genomics

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Nature Biotechnology

@NatureBiotech

1 month

Branched chemically modified poly(A) tails enhance the translation capacity of mRNA

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Nature Biotechnology

@NatureBiotech

2 years

The first peptide vaccine designed to elicit T-cell immunity against SARS-CoV-2, rather than antibody responses, appears to be safe and broadly protective against a range of worrisome viral variants, including Omicron

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Nature Biotechnology

@NatureBiotech

4 years

RNA timestamps identify the age of single molecules in RNA sequencing

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Nature Biotechnology

@NatureBiotech

7 months

The community of the DAO Decentralized autonomous organizations are growing as alternative research funding models, but are also strong scientific communities. We should get on board

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Nature Biotechnology

@NatureBiotech

2 years

In Brief: Japan approves the sale of two CRISPR-edited fish: a tiger puffer and a red sea bream, both developed by the Kyoto-based startup Regional Fish Institute with Kyoto University and Kindai University

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Nature Biotechnology

@NatureBiotech

3 years

To celebrate #BlackHistoryMonth we’re highlighting outstanding Black researchers around the US. Today, we recognize Ishmail Abdus-Saboor, assistant professor of biology at Penn #BHM

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Nature Biotechnology

@NatureBiotech

4 months

Control of mammalian gene expression by modulation of polyA signal cleavage at 5′ UTR

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Nature Biotechnology

@NatureBiotech

4 years

A tissue-engineered uterus supports live births in rabbits

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Nature Biotechnology

@NatureBiotech

2 years

Can synthetic biology provide a sustainable alternative to petrochemicals? Liew et al. engineer bacteria to convert greenhouse gases into useful chemicals

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Nature Biotechnology

@NatureBiotech

3 years

The RNA Atlas expands the catalog of human non-coding RNAs

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Nature Biotechnology

@NatureBiotech

6 years

Repair of double-strand breaks induced by #CRISPR –Cas9 leads to large deletions and complex rearrangements #genomeediting

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Nature Biotechnology

@NatureBiotech

3 years

A comprehensive library of human transcription factors for cell fate engineering

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Nature Biotechnology

@NatureBiotech

2 years

We’re highlighting outstanding Black researchers around the US to celebrate #BlackHistoryMonth . Today we recognize Bryan Bryson, assistant professor of biological engineering at MIT, whose lab is developing new tools to dissect the complex dynamics of bacterial infection

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Nature Biotechnology

@NatureBiotech

2 years

Single-sequence protein structure prediction using a language model and deep learning

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Nature Biotechnology

@NatureBiotech

2 months

With six approved drugs, siRNA is now an established therapeutic modality poised for expansion

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Nature Biotechnology

@NatureBiotech

5 months

The extended machine learning tool RoseTTAFoldNA predicts the structures of RNA- and DNA-binding proteins. #NBThighlight

Accurate prediction of protein–nucleic acid complexes using RoseTTAFoldNA

Nature Methods - RoseTTAFoldNA extends the RoseTTAFold2 platform to predict the structures of protein–DNA and protein–RNA complexes.

www.nature.com

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Nature Biotechnology

@NatureBiotech

3 years

mRNA vaccines take on immune tolerance. A tolerizing mRNA vaccine prevents autoimmune disease in mice #NBTNV

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Nature Biotechnology

@NatureBiotech

3 years

mRNA vaccines take on immune tolerance. A tolerizing mRNA vaccine prevents autoimmune disease in mice #NBTNV

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Nature Biotechnology

@NatureBiotech

2 years

We celebrate #BlackHistoryMonth by recognizing Georgia Tech professor Manu Platt, who studies how cells sense, respond and remodel their immediate environments for repair and regeneration in health and disease, and translates that knowledge to address global health disparities

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Nature Biotechnology

@NatureBiotech

2 months

RNA interference in the era of nucleic acid therapeutics

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Nature Biotechnology

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2 years

Cell types of origin of the cell-free transcriptome

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Nature Biotechnology

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2 years

SignalP 6.0 predicts all five types of signal peptides using protein language models

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Nature Biotechnology

@NatureBiotech

4 years

#Coronavirus vaccine developers are wary of a dangerous phenomenon known as antibody-dependent enhancement, in which non-neutralizing antibodies could enhance viral entry into cells and viral replication and end up worsening infection

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Nature Biotechnology

@NatureBiotech

4 years

@phylogenomics Nature Bistechnology

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Nature Biotechnology

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2 years

A humanized mouse model of chronic COVID-19

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Nature Biotechnology

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2 years

Programmable deletion, replacement, integration and inversion of large DNA sequences with twin prime editing

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Nature Biotechnology

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4 years

Cell-free biosensors for rapid detection of water contaminants

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Nature Biotechnology

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4 months

Programmable protein expression using a genetically encoded m6A sensor

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Nature Biotechnology

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3 years

Light-activated genetic therapy to treat blindness enters clinic

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Nature Biotechnology

@NatureBiotech

4 years

CRISPR pioneers Doudna and Charpentier win 2020 Nobel Prize for Chemistry #NBTintheNews via @GENbio

CRISPR Pioneers Doudna and Charpentier Win 2020 Nobel Prize for Chemistry

Jennifer Doudna and Emmanuelle Charpentier, pioneers in the development of CRISPR technology as a “genetic scissors," have won the 2020 Nobel Prize for Chemistry.

www.genengnews.com

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Nature Biotechnology

@NatureBiotech

6 months

Scalable genetic screening for regulatory circuits using compressed Perturb-seq

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Nature Biotechnology

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3 years

Wearable materials with embedded synthetic biology sensors for biomolecule detection

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Nature Biotechnology

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2 years

Engineering circular RNA for enhanced protein production

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Nature Biotechnology

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4 months

Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo

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Nature Biotechnology

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3 years

RNA demethylation increases the yield and biomass of rice and potato plants in field trials

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Nature Biotechnology

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2 years

A highly photostable and bright green fluorescent protein

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Nature Biotechnology

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3 years

Successfully inducing tolerance with an anti-inflammatory mRNA vaccine could transform the treatment of autoimmune diseases, allergies and allogeneic transplantation #NBTNV

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Nature Biotechnology

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1 year

Combinatorial design of nanoparticles for pulmonary mRNA delivery and genome editing

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Nature Biotechnology

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3 years

Computational principles and challenges in single-cell data integration

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Nature Biotechnology

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1 year

Integration of whole transcriptome spatial profiling with protein markers

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Nature Biotechnology

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4 months

In vivo human T cell engineering with enveloped delivery vehicles

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Nature Biotechnology

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4 years

Congratulations to Emmanuelle Charpentier and Jennifer Doudna on winning the Nobel Prize in Chemistry for the CRISPR-Cas9 editing tool that has “revolutionized” the life sciences. Listen to a recent Nature Biotech podcast with Doudna and Liu.

CRISPR Roundtable: Liu and Doudna | Forum on Acast

David Liu and Jennifer Doudna talk with our Senior Editor Markus Elsner about the state of the genome editing field and what challenges remain, especially as various therapies are now entering the...

play.acast.com

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Nature Biotechnology

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3 years

To celebrate #BlackHistoryMonth we're highlighting trailblazing Black researchers in the US. Today we recognize Paula Hammond, professor and head of MIT's department of chemical engineering and one of only 25 distinguished scientists elected to all three national academies #BHM

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Nature Biotechnology

@NatureBiotech

1 year

Wireless, closed-loop, smart bandage with integrated sensors and stimulators for advanced wound care and accelerated healing

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Nature Biotechnology

@NatureBiotech

11 days

Why Japan lacks a vibrant biotech industry

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Nature Biotechnology

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1 year

Quantitative analysis of tRNA abundance and modifications by nanopore RNA sequencing

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Nature Biotechnology

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2 years

Deep Visual Proteomics defines single-cell identity and heterogeneity

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Nature Biotechnology

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3 years

A network analysis of COVID-19 mRNA vaccine patents

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Nature Biotechnology

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2 years

Genome-wide mapping of somatic mutation rates uncovers drivers of cancer

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Nature Biotechnology

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4 years

Plants with genetically encoded autoluminescence

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Nature Biotechnology

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3 years

Milestones in Genomic Sequencing charts the history of DNA sequencing technologies and their continuously expanding applications in the 21st century

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Nature Biotechnology

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6 years

Nanopore sequencing and assembly of a human genome with ultra-long reads #DNAsequencing #nextgensequencing

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Nature Biotechnology

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4 years

Generalizing RNA velocity to transient cell states through dynamical modeling

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Nature Biotechnology

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6 years

De novo DNA synthesis using polymerase-nucleotide conjugates

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Nature Biotechnology

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2 years

For #WomensHistoryMonth , we're celebrating outstanding scientists throughout the biotech industry. We recognize @genentech 's Aviv Regev, who has pioneered many leading experimental and computational methods for the reconstruction of circuits, including in single-cell genomics

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Nature Biotechnology

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9 months

The August issue is live On the cover, an artist’s impression of a protein translocating through a nanopore. Yu et al. identify conditions allowing proteins to translocate through a nanopore when driven by an electroosmotic effect

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Nature Biotechnology

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9 months

A cancer vaccine is delivered to the lung by an engineered attenuated influenza virus

An engineered influenza virus to deliver antigens for lung cancer vaccination

Nature Biotechnology - A cancer vaccine is delivered to the lung by an engineered attenuated influenza virus.

www.nature.com

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Nature Biotechnology

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4 years

Deciphering eukaryotic gene-regulatory logic with 100 million random promoters

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Nature Biotechnology

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3 years

CRISPR RNA-guided integrases for high-efficiency, multiplexed bacterial genome engineering

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Nature Biotechnology

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4 months

Prime editing using CRISPR-Cas12a and circular RNAs in human cells

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Nature Biotechnology

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3 months

Scalable, accessible and reproducible reference genome assembly and evaluation in Galaxy

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Nature Biotechnology

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4 years

Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors

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Nature Biotechnology

@NatureBiotech

3 years

Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis

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Nature Biotechnology

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5 years

A systems biology pipeline identifies regulatory networks for stem cell engineering

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Nature Biotechnology

@NatureBiotech

6 months

DNA writing technologies moving toward synthetic genomes

Nature Biotechnology - As new technologies hit the market, synthetic DNA is available faster and cheaper than ever before. Regulators are preparing to step in to limit opportunities for misuse.

www.nature.com

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Nature Biotechnology

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1 year

Microfluidics-free single-cell genomics with templated emulsification

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Nature Biotechnology

@NatureBiotech

11 months

Can microbes save the planet? Genetic engineering and accelerated evolution of microbes aim to help climate change

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Nature Biotechnology

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6 years

A DNA #nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo

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Nature Biotechnology

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2 years

Nanopore sequencing technology, bioinformatics and applications

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Nature Biotechnology

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3 years

We’re highlighting outstanding Black researchers in the US to celebrate #BlackHistoryMonth . Today we recognize UC Davis assistant professor Jamal Lewis, whose lab focuses on the development of novel biomaterial systems that can manipulate the immune system #BHM

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Nature Biotechnology

@NatureBiotech

3 months

The February issue, with a focus on protein engineering, is live Our cover shows the three data types key to machine learning for functional protein design: structure, sequence and labels, from a Review by Notin et al.

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Nature Biotechnology

@NatureBiotech

2 years

Japan approves the sale of two CRISPR-edited fish engineered to grow bigger than their conventional counterparts. The traits are expected to reduce production costs of farming the fish, which will be grown in tanks on land

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Nature Biotechnology

@NatureBiotech

6 years

A standardized bacterial #taxonomy based on genome phylogeny substantially revises the tree of life #phylogenetics

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Nature Biotechnology

@NatureBiotech

10 months

Prediction of on-target and off-target activity of CRISPR–Cas13d guide RNAs using deep learning

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Nature Biotechnology

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3 years

Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children

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Nature Biotechnology

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3 years

Single-cell CUT&Tag profiles histone modifications and transcription factors in complex tissues

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Nature Biotechnology

@NatureBiotech

3 years

High-throughput mapping of a whole rhesus monkey brain at micrometer resolution

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Nature Biotechnology

@NatureBiotech

2 years

Using deep learning to annotate the protein universe

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Nature Biotechnology

@NatureBiotech

2 years

High-plex imaging of RNA and proteins at subcellular resolution in fixed tissue by spatial molecular imaging

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Nature Biotechnology

@NatureBiotech

3 years

Today for #BlackHistoryMonth we recognize rising star Christina Towers, assistant professor in the molecular and cell biology laboratory at the Salk Institute #BHM

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Nature Biotechnology

@NatureBiotech

5 years

Dimensionality reduction for visualizing single-cell data using UMAP #compbio #datamining

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Nature Biotechnology

@NatureBiotech

3 years

Integrating T cell receptor sequences and transcriptional profiles by clonotype neighbor graph analysis (CoNGA)

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Nature Biotechnology

@NatureBiotech

2 years

Mitochondrial variant enrichment from high-throughput single-cell RNA sequencing resolves clonal populations

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Nature Biotechnology

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2 years

Sensitive identification of neoantigens and cognate TCRs in human solid tumors

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Nature Biotechnology

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3 years

Mapping single-cell data to reference atlases by transfer learning

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Nature Biotechnology

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3 years

Today for #BlackHistoryMonth , we recognize trailblazer Kristala Jones Prather, professor of chemical engineering at MIT, whose research is at the forefront of metabolic engineering and synthetic biology #BHM