From
#SingleCell
to cell-based therapies, we’re building capacity for AI applications to cell biology at scale.
@chanzuckerberg
’s Head of Science
@StephenQuake
shares our vision for using AI to help scientists advance our understanding of cell + systems biology
This live video of intestinal tissue taken by Gustavo Meneze shows the wave-like muscle contractions that move food through the digestive tract
🔵 blood vessels
🔴+ 🟢 immune cells
#ImagingTheFuture
Watch 📹
@ChanZuckerberg
is pushing the frontiers of imaging to help researchers everywhere visualize life's processes and understand how they contribute to health and disease
Open source software is 🔑 to science. Many of the packages, libraries + applications crucial to biomedicine are built by researchers who volunteer their time + effort to make these tools available. We’re excited to announce support for
#opensource
tools
#Opensource
software is essential to science—that’s why we’re supporting 42 open source tools that accelerate biomedical research and serve the larger community. Learn about the grantees
Increasing access to bioimaging worldwide will help advance biomedical research and improve health outcomes. Our new RFA aims to expand access to imaging expertise, technologies + capacity building
#ImagingTheFuture
We’re thrilled to share that we’re launching a new
@CZBiohub
in New York!
Bringing together engineers + scientists at
@Columbia
,
@RockefellerUniv
and
@Yale
,
#CZBiohubNY
will engineer immune cells for earlier detection & treatment of disease
Science should be by and for everyone. In partnership with
@theNASEM
, we’re excited to welcome 25 Science Diversity Leadership grantees who are diversifying biomedicine through research + mentorship 🙌🏽🙌🏿🙌🏾
A T-cell (green) attacks a cancer cell (blue). Our new RFA aims to support imaging
#tech
so researchers can watch cell dynamics in real time. 📹 by Alex Ritter using an Andor Revolution spinning disk system with an Olympus microscope
We’re excited to announce that the
@ChanZuckerberg
Institute for Advanced Biomedical Imaging’s initial focus will be to identify and map the position of every protein in a cell.
Learn more from our co-founder’s exclusive
@Medscape
interview:
#Opensource
software is essential to science. That’s why we’re awarding 23 grants to support open source tools that accelerate biomedical research and serve the larger scientific community.
Using spatial and
#SingleCell
transcriptomics, a
@nature
publication from
@StephenQuake
& Thomas Sudhof’s teams unravels the cellular + molecular architecture of long-term memory consolidation
Today we announced funding for 85 one-year projects that will focus on developing an open set of computational tools, algorithms, visualization methods and benchmark datasets for scientists working on the
@humancellatlas
. Learn more about the projects:
Our new internationally-focused RFA will fund imaging cores and network organizations from select countries that bring together imaging scientists to collaborate and share expertise. Learn more ⤵
#ImagingTheFuture
🚨
#OpenSource
tools are the invisible foundation of biomedicine. That’s why we’re continuing to support open source software projects essential for scientists. Learn more about our grantees
We’re excited to announce that David Agard, Bridget Carragher + Clint Potter have joined our new
@ChanZuckerberg
Imaging Institute to bring together scientists and engineers to develop new cryoelectron microscopy imaging hardware and software
🧵
🚨 New funding alert 🚨 Imaging core facilities and network organizations from Latin America, the Caribbean, Africa + former Soviet countries are invited to apply to
@ChanZuckerberg
’s RFA to support increased global access to bioimaging
#ImagingTheFuture
Grantees are recognized for their track record of supporting
#DiversityinSTEM
+ their mentorship of the next generation of biomedical researchers. Learn about their projects ⤵️
.
@Caltech
chemical engineer Mikhail Shapiro is creating the first acoustic biomolecules allowing ultrasound to image how specific cells function deep inside the body. This work will be transformative for neuroscience, immunology, cancer biology and more
#ImagingTheFuture
#ScienceAsArt
🎨
This mesmerizing display of color, captured using lattice light-sheet imaging, shows the dynamic movement of macrophage immune cells during a 3-minute timelapse.
📹 by CZI Imaging Scientist
@DrNickCondon
of
@IMBatUQ
#ImagingTheFuture
💻 We’re releasing the CZ Software Mentions Dataset—a dataset of 67M software mentions mined from biomedical literature—to understand how widely research software + open source tools are used across disciplines.
Explore the dataset ⤵️
#TechForTheFuture
🟪= mitochondria
🟦= cell nucleus
🟩= mitochondrial DNA
Many diseases, including hearing loss, are caused by damage to mitochondria and mitochondrial DNA. Imaging Scientist Uri Manor studies how damage to mtDNA is communicated to the cell body + the nucleus
#ImagingTheFuture
Collaboration drives progress in
#science
. Our new Seed Networks grants bring together 200+ scientists, engineers, and physicians to contribute to the
@humancellatlas
! Learn more:
#HumanCellAtlas
Microscopy—critical to biomedicine—generates large volumes of complex data that pose significant computational challenges. We’re excited to announce funding for open-source software efforts to improve image analysis and visualization:
We’re excited to share that
@Meta
, a free research discovery tool, is now available. Meta provides a faster way to understand, organize, and explore science through personalized feeds. Researchers can now sign up for a free account
🚨Funding opportunity 🚨
The Essential
#OpenSource
Software for Science program supports maintenance, growth, development + community engagement for critical tools used by biomedical scientists globally
We’re excited to announce 30 grantees to our
#RareAsOne
Network. These patient-led organizations are partnering with clinicians and researchers to accelerate research for their
#RareDisease
We’re thrilled to welcome our Science Diversity Leadership grantees to CZI HQ! Over three days, scientists led panels + gave talks on how their labs are accelerating research across biomedicine
#DiversityInSTEM
We’re excited to welcome researchers and pediatricians who are studying childhood health + disease. Congratulations to
@ChanZuckerberg
’s Pediatric Networks for the
@humancellatlas
grantees! Learn more about their projects
We’re welcoming 60 new grantees to
@ChanZuckerberg
’s Neurodegeneration Challenge Network! These researchers are piloting innovative approaches to fighting neurodegenerative diseases like
#Alzheimers
,
#Parkinsons
+
#ALS
We require our grantees to:
💻Deposit software code to a repository such as
@github
📝Submit results to preprint servers like
@biorxivpreprint
🔬Make experimental protocols accessible via sites like
@protocolsIO
Read about our support of open science:
“Trainees need mentorship, both technically and for career development, to ensure work from the lab progresses and that they fulfill their career aspirations.”
-
@IshmailSaboor
, researcher at
@ZuckermanBrain
🔊 We’re excited to support 14 new projects developing imaging
#tech
, and launch a new funding opportunity for software engineers to create plugins for
@napari_imaging
#ImagingTheFuture
There are no effective ways to cure, prevent or treat most neurodegenerative diseases like
#Alzheimers
,
#Parkinsons
and
#ALS
. Our new RFA aims to help change that
Did you know?
#CZCellxGene
has the largest repository of standardized
#SingleCell
data from 45M unique cells across tissues, including the:
👁️ Retina
🧠 Brain
🫁 Lungs
🫀 Heart
+ more
Discover something new:
New imaging grants will
💻 Increase access to imaging expertise +
#tech
🔗 Foster collaborations between imaging scientists + researchers
🌍 Increase representation of regional imaging scientists in the global community
Apply
#ImagingTheFuture
We require our grantees to publish detailed methods on a site like
@ProtocolsIO
, ensuring the best protocols are available to all scientists. This saves time, money, and—most importantly—helps science move faster. We’re proud to support
@ProtocolsIO
:
Meet the 18 new teams diving deep into the mechanisms of metabolism, featuring projects exploring spatial mapping, metabolic networks + metabolite biosensors
We’re excited to support 64 interdisciplinary teams that are taking innovative approaches to study fundamental
#neuroscience
+ neurodegenerative diseases. Read more about our second cycle of
@ChanZuckerberg
’s Neuroscience Collaborative Pairs Pilot Projects
Microscopy—critical to biomedicine—generates large amounts of complex data for scientists to visualize and analyze. Today we announced funding for CZI Imaging Scientists, who will help biologists leverage modern technology for microscopy data.
We are planning to build a high-performance computing cluster with 1000+ GPUs to accelerate AI for biomedical science, including advancing the development of new virtual cell 👇🪡
Priscilla Chan and
@karliekloss
present the
#BreakthroughPrize
Life Sciences award to Dr. Virginia Man-Yee Lee of
@Penn
for inventing a protein roadmap to neurodegenerative disorders and elucidating common mechanisms of degeneration in diseases like
#Parkinsons
+
#ALS
Grantee
@channyskye
of
@EvansLab
describes her mentoring style as building relationships where trainees cultivate:
🔬research confidence
🥼a STEM identity
🤔critical thinking skills
What’s your mentoring style?
#MentoringMonth
Today we’re announcing funding for
@iamalsorg
, a patient-led organization dedicated to raising awareness of
#ALS
and empowering patients to lead the search for a cure
We’re excited to announce our new Imaging Scientists Request for Applications! This program aims to accelerate biomedicine by improving microscopy tools and facilitating better collaboration between biologists and technology experts.
We’re excited to announce that we’re scaling the
@CZBiohub
& launching a new Biohub in Chicago!
#CZBiohubCHI
will build new tech to precisely measure biological processes in human tissues in real time and at unprecedented resolution🧵👇🏻
Exciting news!
#CZCellxGene
now has 50M+ unique cells + 915 datasets, providing an even more reference-quality
#SingleCell
data for you to download & visually explore.
Thanks to all the researchers who have contributed their data to cellxgene!
At the
@EMBL
#ImageAnalysis
conference,
@thefreemanlab
announced CZI is supporting the work of 3 Imaging Software Fellows who are building critical and widely-used open-source tools: scikit-image,
#ImageJ
/ Fiji, and CellProfiler.
Congratulations to Dr. Sarah Teichmann -- co-leader of the
@humancellatlas
& Head of Cellular Genetics
@sangerinstitute
-- for being featured as one of 30 women leaders in UK healthcare. Great to see women like Sarah leading the way in
#STEM
.
The majority of rare diseases are not well understood + less than 5% have approved treatments. The
#RareAsOne
Project will connect communities of patients, researchers + clinicians to work together to find cures
#RareDisease
We’re excited to welcome new imaging grantees!
9 new Deep Tissue Imaging projects will drive development of imaging technology focused on obtaining cellular resolution readouts within complex living organisms.
Learn about the projects
“Increasing diversity in science will identify novel genetic variations affecting cellular function, empowering studies to discover new biological insights.”
@AleMedinaRivera
hopes studies of populations in Mexico will help to understand the higher rates of lupus
Collaboration is 🔑 to fighting
#RareDisease
.
@yaya4HL
founder Ron Garber knew he could accomplish more if he combined efforts with other affected families along with researchers and clinicians
#RareAsOne
🚨Funding opportunity 🚨
We’re excited to announce a fourth cycle for our Essential
#OpenSource
Software for Science RFA, which funds software projects that support the computational foundations of biomedical science 👩🏽💻👨🏻🔬 🧵
“Future advances in imaging technology will require highly interdisciplinary collaborations, combining hardware, computational methods and molecular tools.” -Chemist and
@ChanZuckerberg
Deep Tissue Imaging grantee Claire Deo
#ImagingTheFuture
This is fat tissue under a microscope 🔬
Notice how the small blood vessels 🔴 go all throughout the fat cells 🔵, ready to deliver immune cells 🟢 where needed
📷 Gustavo Menezes
@bioimagingbr
#ImagingTheFuture
The precisely coordinated cell movements of the early embryo are key to how organisms form different tissues.
Here are some of those movements in all their glory, captured in a 12-hour timelapse of a zebrafish embryo by
@czbiohub
’s
@loicaroyer
+
@Merlin_Lange
#ImagingTheFuture
We’re excited to launch the
#RareAsOne
request for applications—providing up to 10
#RareDisease
patient orgs with funding, training, tools + mentorship. Learn more and apply:
This morning, hundreds of people came together in Times Square to put a face to neurodegenerative diseases and stand for their loved ones fighting for
#CuresForAll
. We are proud to stand with them.
"The Chan Zuckerberg Initiative is just starting, and we have a lot to learn. But I’ve been lucky to work in areas in which the free exchange of ideas and results is the norm. In my experience, such an approach creates the most dynamic fields."
@betenoire1
“We are interested in describing the mutations + molecular characteristics associated with types of cancer that are important in Mexico & other Latin American countries.”
#RareDisease
Acral melanoma is understudied in Mexico.
@daniela_oaks
is changing that
#LatinxHeritageMonth
As part of our work in
#neuroscience
+
#neurodegeneration
, we are committed to supporting early career researchers across disciplines & expertise.
Meet our second cohort of Ben Barres Early Career Acceleration Awards grantees ⤵️
We hosted a workshop on accelerating
#OpenScience
in Latin America to enhance participation + collaboration in computational biomedicine and open research 🌎💻
#CZILatAmMtg
#OpenSource
software is the future of science. Thanks to everyone who joined us for our meeting on the challenges and progress of open source in accelerating research
#EOSSmtg
We believe in the importance of rewarding the creators of the often invisible but critical computational infrastructure for science. Read about what we learned from the first cycle of our Essential
#OpenSource
#Software
for Science RFA
“Knowing more about inflammation will increase our understanding of many diseases and improve our ability to cure, prevent or manage them.” —
@JCoolScience
Read 👇
CZI Imaging Scientist Leonel Malacrida (
@MalacridaLab
) is developing an advanced bioimaging facility in Uruguay to provide state-of-the art
#tech
for all researchers in the country & train the next generation of scientists in modern imaging and analysis methods
#ImagingTheFuture
“Having leaders from diverse backgrounds creates environments where there are shared personal and academic experiences between advisors and trainees. This, in turn, leads to more impactful mentoring experiences.”
-Grantee
@ArmstrongFlyLab
Neurodegenerative diseases are a leading cause of disability and death worldwide. We seek to support a stronger scientific understanding of neurodegeneration and will soon invite applications to join our Neurodegeneration Challenge Network. Details here:
🎉 Thrilled to share our new imaging grantees! We’re supporting 41 projects to develop + maintain plugins on
#OpenSource
tool
@napari_imaging
, and 17 global imaging groups increasing access to imaging
#tech
+ fostering collaboration
#ImagingTheFuture
This week, our
#SingleCell
biology grantees gathered to share their research, connect with other research groups + discuss how they can use new data & technologies to understand health & disease.
Attendees, what was your favorite part of the meeting?
Join us in welcoming
@USCDornsife
’s Scott Fraser to our team as VP of Science Grant Programs 🥳 Bridging chemistry, engineering + physics to unravel the complexities of biology, he knows the power of innovation & collaboration in science. We’re excited to have him on board
Join us in celebrating the launch of the Seattle Hub for Synthetic Biology with
@AllenInstitute
+
@UWMedicine
. 🎉 Led by
@JShendure
, this new collaboration will build tech to understand temporal dynamics of cells & whole organism perturbation ➡️
#SeaSynBio
Computational skills are 🔑 for scientists to fully leverage their data. We’re partnering with
@MooreFound
to support
@thecarpentries
to teach programming and data science skills to researchers worldwide
#bioinformatics
“You know, you’re 37. You see a whole life in front of you and now all of a sudden that life may not exist.” -
@bsw5020
.
Read how
#RareDisease
warrior Brian Wallach founded
@iamalsorg
to change the future for his family and others with
#ALS
There are no effective therapies for diseases like
#Alzheimers
,
#Parkinsons
+
#ALS
.
We need to support early career researchers to bring new ideas and approaches to solving neurodegenerative disorders
Mothers Liz Berger and Beth Buccini started
@ddx3x
Foundation to make a difference in their daughters’ lives and other children affected by DDX3X. Read about their work to find a cure for this
#RareDisease
#RareAsOne
Thank you to everyone who made the CZI Computational Tools for the
@humancellatlas
meeting such a success. It was an exciting demonstration of the power of open cross-institutional scientific collaboration. Here’s to the year ahead!
We’re launching a new COVID-19 task force with
@CZBiohub
,
@UCSF
and
@Stanford
to increase collaboration and better respond to the coronavirus outbreak in the Bay Area
“Latin America has great potential and is commonly overlooked in research; there are amazing groups worth collaborating with.”
@AleMedinaRivera
's research centers on diseases like lupus + Parkinson's with a strong focus on including Mexican participants
#LatinxHeritageMonth