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@AllenInstitute

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The Allen Institute is committed to solving mysteries of bioscience — researching the unknown of human biology, in the brain, the cell and the immune system.

Seattle, WA
https://t.co/M1COyvb9GM
Joined October 2010
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@AllenInstitute
Allen Institute
@AllenInstitute
5 months
The first cellular map of a mammalian brain is here. 🧠✨ Over 6 years and 32 million cells in the making, the complete adult mouse brain cell-type atlas reveals astonishing diversity and regional specificity. Dive deeper: @nature #studyBRAIN #BICCN
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@AllenInstitute
Allen Institute
@AllenInstitute
9 months
Take a break from scrolling and relax with this dazzling video of the neurotransmitter glutamate being released into synapses, made possible by an indicator developed by @abhi_aggarwal1 , @PodgorskiLab , & team. Learn more in @NatureMethods :
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5 years
Happy birthday to Santiago Ramón y Cajal the "father of modern #neuroscience ."
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4 months
The fireworks in your mind. 🧠✨ This sparkling video shows the neurotransmitter glutamate being released into synapses, made possible by an indicator developed by @abhi_aggarwal1 , @PodgorskiLab , and team. #HappyNewYear #NYE
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10 months
Introducing the Allen Brain Cell (ABC) Atlas [ʙᴇᴛᴀ] representing ~5,200 newly transcriptomic-defined cell types and their spatial locations across the whole mouse brain. 🧵 Access ABC Atlas data visualization & pre-publication #openscience datasets:
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1 year
You're on our mind, Valentine. 🧠❤️
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@AllenInstitute
4 years
Happy birthday to Santiago Ramón y Cajal the "father of modern #neuroscience ."
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@AllenInstitute
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6 years
An international team of researchers, including scientists at our Institute for Brain Science, just introduced the world to a new kind of neuron which is believed to exist only in the human brain. WIRED reports on the newly identified "rosehip cell."
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Meet the Rosehip Cell, a New Kind of Neuron

Transcriptome sequencing technologies are opening the doors to a new era of cellular discovery, and not just in the brain.

www.wired.com
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@AllenInstitute
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@AllenInstitute
3 years
Announcing the most detailed examination of mammalian brain circuitry to date. This data release marries a 3D wiring diagram with the function of tens of thousands of neurons. @bcmhouston @PrincetonNeuro @IARPAnews @awscloud @googlecloud 🧵 👇
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2 years
We are delighted to announce that Dr. Rui Costa ( @ruimcosta ) will join the Allen Institute as our next President and CEO!
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Allen Institute announces Rui Costa as next President and Chief Executive Officer

The Allen Institute named Rui Costa, D.V.M., Ph.D., as its next president and chief executive officer. Costa comes to the Allen Institute from the Mortimer B. Zuckerman Mind Brain Behavior Institute...

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@AllenInstitute
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3 years
#ScienceIsBeautiful 😍 We hope this video of healthy human iPS cells dividing and human heart cells beating brings you a #calming moment of #peace #SciArt #Mitosis #CellScience
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2 years
The most detailed version yet - Researchers can freely access the Allen Mouse Brain Common Coordinate Framework (v3), a complete, high-resolution 3D atlas of the mouse brain. #openscience #neuroscience Read:
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6 years
Uncovering a new type of human brain cell that has never been seen in other animals helps to answer one of the most difficult and intriguing questions in #neuroscience : *What sets our brains apart from those of other animals?*
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1 year
Take a break from doomscrolling and relax with this dazzling video of the neurotransmitter glutamate being released into synapses, made possible by a new indicator developed by @abhi_aggarwal1 , @PodgorskiLab , & team. Out in @NatureMethods : #NeuroTwitter
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1 year
Did you know around half of your brain is not made of neurons? Among the other half is the octopus-like microglia (green) which acts as the brain's janitor and paramedic. Get to know the team and data behind this stunning visualization:
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5 years
We’re releasing new large datasets to accelerate #neuroscience including our first – and the world’s largest – dataset of brain activity gathered using #Neuropixels , a high-resolution probe that can record activity from hundreds of neurons simultaneously.
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6 years
Our Institute for Brain Science recently released the first dataset from live human neurons. This #openscience resource contains electrophysiological, morphological, and transcriptomic properties gathered from individual cells, and models simulating cell activity. #BrainWeek
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4 years
#ScienceIsBeautiful 😍 We hope this video of healthy human iPS cells dividing and human heart cells beating brings you a #calming moment of #peace #SciArt #Mitosis #CellScience
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6 years
Announcing the Allen Integrated Cell: the first predictive and comprehensive, 3D model of a live human cell. #OpenScience
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3 years
Happy birthday to Santiago Ramón y Cajal the "father of modern #neuroscience ."
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4 years
#Neuroscience ’s equivalent of GPS -- our researchers have published a paper in @CellCellPress describing the third iteration of the Allen Mouse Brain Common Coordinate Framework, a high-resolution 3D atlas of the mouse brain. #openscience
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Happy birthday to Santiago Ramón y Cajal the "father of modern #neuroscience ."
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2 years
We released #openscience data comprising the activity of ~300,000 neurons recorded by #Neuropixels probes – the largest data set of this kind ever collected. Now it's time to dig in for #neuroscience analysis. #AllenImpact by @grace_huckins
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A Huge New Data Set Pushes the Limits of Neuroscience

The Allen Institute’s release includes recordings from a whopping 300,000 mouse neurons. Now the challenge is figuring out what to do with all that data.

www.wired.com
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3 years
Our study on the relationship between fluorescent calcium indicators and action potentials is now on eLife. This study shows the limits of using such indicators to measure spiking activity. Spike detection is ~15% under normal "low zoom" imaging: . (1/3)
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Relationship between simultaneously recorded spiking activity and fluorescence signal in GCaMP6...

Simultaneous calcium imaging and cell-attached recording in GCaMP6 transgenic mice in vivo reveals spiking-fluorescence relationship that supports more refined inference of neuronal activities from...

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5 years
Announcing the Allen Institute for Immunology, a new effort to unravel the mysteries of the immune system. Founded by the late @PaulGAllen , this new Institute will work to find better ways to diagnose & treat patients & to prevent immune-related diseases
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2 years
Announcing the Allen Institute for Neural Dynamics, a new #neuroscience research division focused on understanding how the mammalian brain’s computations give rise to complex behaviors like decision making, learning and memory.
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4 years
🧠We are excited to announce new phases of research for our #neuroscience teams.
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11 months
Brain imaging without compromise. ✨🔬 Using technology originally designed for defect detection in electronics manufacturing, the ExA-SPIM microscope is showing scientists the brain as it’s never been seen before. Look into the future of #microscopy at
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8 months
⭐New data are available on the Allen Brain Cell (ABC) Atlas The ABC Atlas provides a platform for visualizing multimodal single cell data across multiple whole-brain datasets simultaneously. #OpenScienceWeek . Visit:
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3 months
Introduce your students to the diversity of cell types in the brain and neuron morphology with this free lesson plan developed with our researchers.
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Neurons: Beyond the Textbook

Explore cell types and how they are defined, and gain a more realistic perspective of neuron morphology

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4 months
✨🔬 Meet ExA-SPIM, a revolutionary new microscope and tissue processing combo developed at the Allen Institute for Neural Dynamics that is showing scientists the brain as it’s never been seen before.
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2 years
Different cell types in the brain have their own connectivity rules and patterns. In a recently published study, our #neuroscience researchers took a deep dive into the connectomics of an important but enigmatic cell type, the chandelier cell. 🧵1 📄
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4 years
Our #neuroscience researchers recently completed the third iteration of the Allen Mouse Brain Common Coordinate Framework, a complete, high-resolution 3D atlas of the mouse brain. #openscience Read:
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2 years
🧠 Which brain cell types are connected, and what do those connections look like? 🤔 Recording from multiple live neurons simultaneously — our researchers mapped thousands of cortical connections to find out. 🧵 1
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How do our neurons connect? New study probes the details of human and mouse synapses

‘Multipatch’ technique catalogs more than 1700 connections between neurons in publicly released dataset

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6 months
Brain imaging without compromise. ✨🔬 Using technology originally designed for defect detection in electronics manufacturing, the ExA-SPIM microscope is showing scientists the brain as it’s never been seen before. Learn more: #SfN23
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3 years
Interesting read: Neuroscientists continue to explore exactly how our brains form memories.
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Brain Cell DNA Refolds Itself to Aid Memory Recall

Researchers see structural changes in genetic material that allow memories to strengthen when remembered.

www.quantamagazine.org
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A new study from our brain science team reveals the most detailed “parts list” of the human brain to date. This could improve how we study and treat brain diseases and disorders such as #anxiety , #depression , and #OCD .
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Highest-Resolution Human Brain 'Parts List' To Date Lays Road Map to Better Treatments for Neurol...

Crucial differences discovered in human and mice brain cells could explain why many drugs that work in the lab don’t work in us

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6 years
You've seen the cartoons in textbooks. Now see what your cells really look like with the Allen Cell Explorer.
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@AllenInstitute
4 months
Introduce your students to the diversity of cell types in the brain and neuron morphology with this free lesson plan developed with our researchers. #AllenLearn
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Neurons: Beyond the Textbook

Explore cell types and how they are defined, and gain a more realistic perspective of neuron morphology

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4 years
Out today in @NatureComms -- see how our team built a high-throughput, automated electron microscopy pipeline and took ~125,000,000 pictures of a tiny sample of brain tissue to reveal its fine wiring. This work is part of the @IARPAnews MICrONS project.
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6 years
How many cell types are in the brain and what role do they play in brain function? Our researchers have established a taxonomy of morphologically- and electrophysiologically-defined cell types from the mouse visual cortex as part of our Cell Types program.
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4 years
On this day 📆 in 2006 Allen Institute for Brain Science announced the completion of our inaugural project: a web-based, 3D map of gene expression in the mouse brain providing scientists with a level of data previously not available. #openscience
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2 years
On this day 📆 in 2006 Allen Institute for Brain Science announced the completion of our inaugural project: a web-based, 3D map of gene expression in the mouse brain providing scientists with a level of data previously not available. #openscience #neuroscience #AllenImpact
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3 years
We don't even understand the brain of a worm, let alone the human brain. #Neuroscience has come a long way, but there are still many unsolved mysteries about the brain. Visit:
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Our founder, the late Paul G. Allen, had an insatiable desire to unravel big mysteries in biology. @Forbes reports on the newly launched Allen Institute for Immunology with goals to unlock the mysteries of the human immune system.
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Today with the @ChanZuckerberg Initiative and @UWMedicine , we’re launching the Seattle Hub for Synthetic Biology ( #SeaSynBio ), a first-of-its-kind research initiative that will reimagine how we study cells by turning them into their own recording devices.
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Seattle Hub for Synthetic Biology launched by Allen Institute, Chan Zuckerberg Initiative, and the...

The Allen Institute, the Chan Zuckerberg Initiative (CZI), and the University of Washington (UW) today announced the launch of the Seattle Hub for Synthetic Biology: a landmark collaboration that...

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Today we are celebrating our sweet sixteen and golden birthday -- 16 years of #AllenImpact ! 💛 🎂
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The brain is mysterious, but one part is ✨ extra ✨ mysterious - the claustrum. There's a lot of activity between it and the cortex, but its role is not completely understood. Learn how our scientists are shining a light on it - literally. ➡️
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7 years
We're pleased to announce the Allen Cell Explorer: a one-of-a-kind, dynamic digital window into the human cell.
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2 months
Neurons are often in the neuroscience spotlight, but there is another star in the brain - astrocytes. Like neurons, they come in a myriad of shapes and types. Meet one of the rarer astrocytes, found only in humans and non-human primates: #SciShots
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Meet our 2021 cohort of Next Generation Leaders: 🧠 @emiliafavuzzi 🧠 @arifahamid 🧠 @lucasmpinto 🧠 @KanakaRajanPhD 🧠 @jestsai 🧠 @ZYanWang Now in its eighth year, early-career scientists in this program help to advise our #neuroscience research.
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11 months
An overactive inflammatory response could be at the root of many long #COVID cases, according to a new study from the Allen Institute for #Immunology and @fredhutch . 🧵
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Many long COVID patients suffer from persistent inflammation, study finds

Molecular footprint of the chronic condition could help guide clinical trial and treatment decisions

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ICYMI, we recently unveiled the first cellular map of a mammalian brain in @nature . 🧠✨ Over 6 years and 32 million cells in the making, the complete adult mouse brain cell-type atlas reveals amazing diversity & regional specificity. More: #studyBRAIN
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Scientists discovered general anesthesia about 170 years ago but still cannot understand why it works. Researchers at Duke University now believe they have discovered the part of the answer.
Scientists Discovered Where Anesthesia Works On the Brain

Rather than inhibiting neurons, anesthesia could also activate individual neurons in the brain A medical miracle happened about 170 years ago when scientists discovered general anesthesia that...

www.sciencetimes.com
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Our first dataset from live human brain cells is publicly available in our Cell Types Database to help researchers to better understand human health & disease and to accelerate #neuroscience worldwide.
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Tight junction protein ZO-1 is our Cell Line of the week 🧫 Our #CRISPR gene-edited fluorescently-tagged human iPS cell lines & plasmids illuminate key structures. These lines & plasmids are openly available through our Allen Cell Collection via .
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Our #openscience resources contain biological features from over 1,000 neurons. Learn more at . #AllenImpact
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Access our Allen Cell Types Database which contains electrophysiological, morphological & transcriptomic properties gathered from individual mouse & human cells: . This work is part of a multi-year project to create a census of cells in the mammalian brain.
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Santiago Ramón y Cajal (1852-1934) made some 2,900 scientific drawings. His intricate pencil and ink drawings told the world: this is how your brain is put together. #neuroscience
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In 'Beautiful Brain,' the secrets of neurons emerge in Nobel-winning scientist's ink and pencil...

Neuroanatomist Santiago Ramón y Cajal's depictions of neurons were key components of his science, but they're also works of art, as an exhibit opening Thursday at the MIT Museum makes clear.

www.statnews.com
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Freely access electrophysiological, morphological, and transcriptomic data measured from thousands of individual mouse & human brain cells via the Allen Cell Types Database: #openscience #SfN23
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ICYMI: 🧠 Our scientists are the first to record electrical properties from #vonEconomo neurons in live human brain tissue -- offering new clues about about this huge rare brain cell, that has been found in only several animals including humans.
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New clues about a huge, rare human brain cell

Study finds human von Economo neurons’ closest cellular cousins and captures first electrical recordings from these large spindle-shaped brain cells

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Brain mapping to speed discovery – we are launching a global collaboration to map all ~200 billion cells in the human brain by their type and function with @NIH BRAIN Initiative funding support. #studyBRAIN #teamscience 🧵1
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A statement from the Allen Institute president and CEO on the passing of our founder @PaulGAllen :
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Wait, what?! 🧐 Did that cell divide into three? Our scientists captured a rare event of cell division gone wrong 🤯 The Allen Institute for Cell Science has tagged a series of structures with fluorescent proteins using hiPSCs: #OpenScience #StemCells
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@AllenInstitute
10 months
Introduce your students to the diversity of cell types in the brain and neuron morphology with this free lesson plan developed with our researchers. #AllenLearn
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Neurons: Beyond the Textbook

Explore cell types and how they are defined, and gain a more realistic perspective of neuron morphology

alleninstitute.org
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Brain-wide neuron tracing reveals that the mysterious mouse claustrum is highly connected to the rest of the brain. In this extreme example, several neurons wrap their axons entirely around the cortex, forming a crown-like structure. 👑 More: #SciShots
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How many different cell types are there in the brain and what role do they play in brain function? Our #OpenScience Cell Types Database contains electrophysiological, morphological, and transcriptomic properties gathered from over 1,000 cells to help researchers learn more.
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Breaking @IARPAnews MICrONS news. We've completed stitching & aligning >100,000,000 pictures of the brain into a massive 2.3 petabyte, 3D dataset, & handed it off to @Princeton for fine-alignment & segmentation. This project is giving us a new window into how the brain is wired.
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🚨🚨NEW VISUAL BEHAVIOR DATA IN THE ALLEN BRAIN OBSERVATORY! 🔬🔬
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Take a look inside healthy human cells with the Visual Guide to Human Cells developed by our Allen Institute for Cell Science. The #openscience resource is publicly available to support research worldwide.
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The brain is full of mysteries. Here are five, and how our scientists are working to solve them.
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Announcing the launch of #OpenScope , a project modeled after shared astronomy observatories that will give researchers around the world access to our "observatory of the mind." #TeamScience
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J. of Comparative Neurology has published our Human Reference Atlas in an unprecedented 350 pg. stand-alone issue.
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Announcing the MICrONs Explorer: A virtual observatory of the cortex 👉 This data portal includes #openscience #electronmicroscopy based reconstructions of cortical circuitry from mouse visual cortex.
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Whole, healthy human brain data is now on the ABC Atlas! Dataset incl. 3 million+ cells sampled from dissections from adult donors. Samples underwent snRNA sequencing and were clustered and categorized by neurotransmitter, region, and more. ABC Atlas:
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The Allen Brain Cell (ABC) Atlas represents ~5,200 transcriptomic-defined cell types and their spatial locations across the whole mouse brain. Access ABC Atlas data visualization and #openscience datasets: #SfN23
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We don't even understand the brain of a worm, let alone the human brain. #Neuroscience has come a long way, but there's still many unsolved mysteries about the brain.
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Meet our 2020 cohort of Next Generation Leaders. “These advisors are really the rising leaders in their fields." — @sejdevries Now in its seventh year, early-career scientists in this program help to advise our #neuroscience research efforts.
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Here you can see a brain cell in two states observed: neuron and neuroff....🙃😂 #TellAJokeDay ! These images are from our #AllenBrainObservatory : a highly standardized survey of cellular-level activity in the mouse visual system. Learn more:
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Access electrophysiological, morphological, and transcriptomic data measured from thousands of individual mouse & human brain cells via the Allen Cell Types Database: | #openscience
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Researchers can freely access the Allen Mouse Brain Common Coordinate Framework (v3), a complete and high-resolution 3D atlas of the mouse brain. Learn more about it at . #SfN23
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Announcing a major enhancement to the Allen Cell Types Database: data from live human brain cells! #OpenScience
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Congrats to our own @HongkuiZeng on being elected to @theNASciences ! She was chosen for her contributions to society's understanding of mammalian brain cells and connections, and leading the development of #OpenScience data and tools.
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Hongkui Zeng elected to the National Academy of Sciences

Zeng was chosen for her contributions to understanding the cells and connections of the brain.

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Our 3D Cell Viewer provides open online access to a large collection of human induced pluripotent #stemcells visualized in three dimensions.
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We 💓 supporting the bioscience community with #openscience resources like our #CRISPR gene edited, fluorescently labeled human iPS cells + hiPSC-derived cardiomyocytes — available via #HeartMonth
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#STEM Educators, incorporate #neuroscience into your high school and college level classes with these free teaching resources developed with our scientists and #openscience data.
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Humans have approximately 86 billion neurons in our brains, woven together by an estimated 100 trillion connections. We asked our Christof Koch and his colleagues to reflect on how much we still don’t know about the brain. 🔍 #BrainWeek
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5 unsolved mysteries about the brain

Can we understand our own brains? We have a long way to go, neuroscientists say.

alleninstitute.org
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@AllenInstitute
Allen Institute
@AllenInstitute
7 months
What makes us human? Today in @ScienceMagazine , a large research consortium funded by @NIH #studyBRAIN initiative shared new insights on how human brain cells differ from other humans and our closest primate relatives. 🔗 More on some of the papers. 🧵⬇️
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What makes us human? Detailed cellular maps of the entire human brain reveal clues

Collectively, the studies represent the most comprehensive analysis of the whole human brain to date, profiling over one million cells and 100 brain regions with extreme precision to reveal cell...

alleninstitute.org
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@AllenInstitute
Allen Institute
@AllenInstitute
1 year
Our #CellLineOfTheWeek is alpha tubulin! 🧫 Our human iPS cell lines & plasmids – fluorescently-tagged to illuminate cellular structures – are openly available to accelerate discovery: 📦 Distributed by @Coriell_science and @Addgene . #OpenScience
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@AllenInstitute
Allen Institute
@AllenInstitute
3 years
Announcing the most comprehensive map of any part of the mammalian brain ever. Our researchers together with #BICCN -supported teams published a collection of studies mapping the motor cortex — the part of the brain that controls movement. #studyBRAIN
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@AllenInstitute
Allen Institute
@AllenInstitute
2 years
Teach your students the concept of cell types and give them a more realistic perspective of neuron morphology with this free lesson plan developed with our researchers. #AllenLearn #STEM #Neuroscience #OpenEd #OpenScience
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@AllenInstitute
Allen Institute
@AllenInstitute
3 years
Simularium (ʙᴇᴛᴀ) — a new tool by the Allen Institute for Cell Science — makes it easy to share and interrogate interactive 3D visualizations of biological simulation trajectories and related plots directly in a web browser. Check it out:
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@AllenInstitute
Allen Institute
@AllenInstitute
1 year
Meet our 2022 cohort of Next Generation Leaders: 🧠 @Constantinatheo 🧠 @HeatherDSnell 🧠 @shekharlab 🧠 @KaueMCosta 🧠 @LeenaAIbrahim 🧠 @EissaTahra Now in its ninth year, early-career scientists in this program help to advise our #neuroscience research.
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Allen Institute
@AllenInstitute
2 years
See human cells divide with incredible detail 🤩 This week's #SciShots features high quality imaging by @zeiss_micro on a #latticelightsheet microscope using one of our human iPSC lines (labelled with mEGFP Lamin B1) to examine #DNA replication. Read:
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@AllenInstitute
Allen Institute
@AllenInstitute
6 years
Using open-source code, a team of researchers in Japan used our Mouse Brain Atlas to help build a brain atlas at single-cell resolution. #openscience
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Allen Institute
@AllenInstitute
6 years
“The Beautiful Brain: The Drawings of Santiago Ramón y Cajal” presents 80 small notebook renderings in shifting combinations of ink and pencil that are considered among the world’s greatest scientific illustrations. | #Cajal
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A Deep Dive Into the Brain, Hand-Drawn by the Father of Neuroscience (Published 2018)

The breakthrough drawings of Santiago Ramón y Cajal are undeniable as art.

www.nytimes.com
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@AllenInstitute
Allen Institute
@AllenInstitute
4 months
In collaboration with @Harvard and #studyBRAIN Initiative partners, we recently unveiled the first complete cellular map of a mammalian brain. Learn more about MERFISH - one of the lab techniques behind the map: @USBrainAlliance
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Scientists create first molecular cell atlas of a mammal brain — Harvard Gazette

Harvard team's work is part of a national neuroscience study seeking to revolutionize understanding of the human brain.

news.harvard.edu
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@AllenInstitute
Allen Institute
@AllenInstitute
3 years
Interesting weekend read: Scientists are starting to unravel how our organs talk to the brain and how the brain talks back. by @em_underwood
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@AllenInstitute
Allen Institute
@AllenInstitute
2 years
We just released the largest dataset of #Neuropixels recordings ever collected with detailed information from more than 300,000 neurons 😯 These data are freely available to speed #neuroscience research & discovery: | #openscience 🧵2
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@AllenInstitute
Allen Institute
@AllenInstitute
5 years
As part of our effort to discover the brain’s “periodic table," our researchers recently described a large profile of neuron types based on their 3D shape and their electrical behavior. #brainscience
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