Chan Zuckerberg Biohub Network @czbiohub Twitter profile

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Chan Zuckerberg Biohub Network

@czbiohub

5 months

Introducing Mantis, a two-in-one microscope designed at #CZBiohubSF that enables rapid high-dimensional imaging of molecular dynamics in the context of cell morphology. 🧵1/7 Preprint: ⬇️

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Chan Zuckerberg Biohub Network

@czbiohub

3 years

Tabula Sapiens is a first-draft single cell transcriptomic atlas of 2 human donors, 14 organs, and 150,000 cells. This collaborative project provides a molecular characterization of cellular diversity in the human body. Learn more ⤵️ (1/5)

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Chan Zuckerberg Biohub Network

@czbiohub

3 years

A significant milestone for the Tabula Sapiens Consortium! The first major publication for this project, on @biorxiv today, details a single-cell transcriptomic atlas of nearly 500,000 cells from 24 different human tissues & organs across 14 donors. (1/6)

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Chan Zuckerberg Biohub Network

@czbiohub

2 years

We're excited to welcome our new cohort of Investigators! 86 awardees from @Stanford , @UCSF , and @UCBerkeley from a broad range of disciplines will undertake creative and innovative research to help solve the biggest challenges in biomedicine.

Investigator Program - CZ Biohub San Francisco

Funding research by scientists, engineers, and technologists from UC Berkeley, Stanford, and UCSF

www.czbiohub.org

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Chan Zuckerberg Biohub Network

@czbiohub

2 years

Out today in @ScienceMagazine , the Tabula Sapiens is 1 of 4 new open-access cross-tissue human cell atlases. This is a major milestone for #singlecell biology, giving us a deeper understanding of the human body and the diseases that afflict it.

The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans

Single-cell transcriptomics provides a molecularly defined phenotypic reference of human cell types that spans 24 human tissues and organs.

www.science.org

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Chan Zuckerberg Biohub Network

@czbiohub

2 months

The CZ Biohub Network is pleased to welcome the biomedical & AI expertise of 3 new members to our Board of Directors: 🌟Sam Altman/ @sama , @OpenAI CEO 🌟Sam Hawgood, @UCSF Chancellor 🌟Mike Schroepfer/ @schrep , Partner @Gigascale View the full Board:

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Chan Zuckerberg Biohub Network

@czbiohub

6 months

New in @Nature : #COVID patients with specific mutations in NFKB2 gene develop antibodies to type I interferons, which are associated with a severe disease course, often involving hospitalization and ICU care. 🧵 1/5

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Chan Zuckerberg Biohub Network

@czbiohub

4 years

#CZBiohub welcomes Dr. Sandra Schmid @slschmid_lab as our first Chief Scientific Officer. Her recent election to @theNASciences underscores her contributions to understanding the cell, a cornerstone of Biohub’s work. We're excited & honored to have her on our team

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Chan Zuckerberg Biohub Network

@czbiohub

4 years

. @UCSF now offering free #COVID19 testing to 9 #BayArea counties in partnership with Biohub, @ChanZuckerberg and @CAgovernor #coronavirus

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Chan Zuckerberg Biohub Network

@czbiohub

3 years

Calling all computational biologists, data scientists, & machine learning scientists: Join our competition at @NeurIPSConf that presents tasks on multimodal single-cell data using public datasets and a first-of-its-kind multi-omics benchmarking dataset.

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Chan Zuckerberg Biohub Network

@czbiohub

2 years

Published today in Science, a team from CZ Biohub and @MPI_Biochem combined genome engineering, confocal live-cell imaging, mass spectrometry, and data science to systematically map the localization and interactions of human proteins. 🧵

OpenCell: Endogenous tagging for the cartography of human cellular organization

Combining genome engineering, live-cell imaging, mass spectrometry, and data science are used to map the localization and interactions of human proteins.

www.science.org

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Chan Zuckerberg Biohub Network

@czbiohub

4 years

Increasing #coronavirus testing capacity -- through ops support, informatics and protocol development -- would not be possible without the scientists and volunteers supporting healthcare facilities and local authorities at the frontlines of the #COVID -19 pandemic

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Chan Zuckerberg Biohub Network

@czbiohub

1 year

📣We have exciting news! A new CZ Biohub is launching in Chicago, bringing together @UChicago , @NorthwesternU & @UofIllinois and scaling the collaborative model created by #CZBiohubSF to do audacious #science .

CZ Biohub Chicago Launches

CZ Biohub Chicago will create new technologies to better understand and treat inflammation—a key contributor to many diseases

www.czbiohub.org

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Chan Zuckerberg Biohub Network

@czbiohub

27 days

In Memoriam: Lubert Stryer (1938–2024), a giant in biochemistry and a key early contributor to the success of the Biohub. Read a remembrance from Biohub SF president Joe DeRisi.

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Chan Zuckerberg Biohub Network

@czbiohub

2 years

Complementary papers from @broadinstitute , @sangerinstitute , and CZ Biohub for the multi-tissue @HumanCellAtlas were published in @ScienceMagazine today, bringing the HCA goal of mapping every cell type in the human body a giant step closer. Check them out

Mapping cell types across human tissues

Single-cell analyses reveal tissue-agnostic features and tissue-specific cell states

www.science.org

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Chan Zuckerberg Biohub Network

@czbiohub

6 years

The Chan Zuckerberg Biohub is awarding $13.7 million over three years to support cutting-edge biomedical research from seven teams of scientists, physicians, and engineers. Each team includes faculty members from @UCSF , @UCBerkeley and @Stanford .

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Chan Zuckerberg Biohub Network

@czbiohub

2 years

The Chan Zuckerberg Biohub Network is seeking applications to create the next CZ Biohub bringing together 3 or more U.S.-based institutions. Our goal is to unite regional scientific & tech institutions to pursue a grand scientific challenge. Learn more:

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Chan Zuckerberg Biohub Network

@czbiohub

7 months

We’re thrilled to celebrate the launch of #CZBiohubCHI , led by @ShanaOKelley and bringing together @NorthwesternU , @UofIllinois , @UChicago . Scientists will engineer instrumented tissues to understand the role of inflammation in disease. Learn more:

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Chan Zuckerberg Biohub Network

@czbiohub

1 year

Exciting news! Biohub researcher & @Stanford prof Peter Kim developed a promising new Covid #vaccine that, in experiments, shows robust protection against all Variants of Concern. Read the preprint &🧵on this work. 1/n

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Chan Zuckerberg Biohub Network

@czbiohub

5 years

#CZBiohub investigator @UCSF prof Bo Huang & his lab developed a #CRISPR Tag system that allows imaging of genes of living cells. His work opens up the opportunity to explore the functional significance & spatiotemporal dynamics of different gene elements.

Efficient labeling and imaging of protein-coding genes in living cells using CRISPR-Tag

Nature Communications - Difficulties in imaging non-repetitive genes impair our ability to explore their dynamics. Here the authors present CRISPR-Tag, which marks genes of interest with small...

www.nature.com

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Chan Zuckerberg Biohub Network

@czbiohub

7 months

The Biohub Network was formed to tackle big scientific challenges. We’re excited to grow with the launch of #CZBiohubNY ! Scientists from @Columbia , @RockefellerUniv & @Yale will engineer immune cells for earlier disease detection & treatment. Read more ⬇️

CZI Launches New Biohub in New York

CZ Biohub New York will create new technologies to detect and treat diseases earlier, including cancers and neurodegenerative diseases

www.czbiohub.org

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Chan Zuckerberg Biohub Network

@czbiohub

2 years

Build your own #lightsheetmicroscope ! Guest scientist @MelissaPezzotti worked with Biohub’s @yi_xiyu to build a DaXi microscope in only 3 months. #OpenScienceWeek #DYI

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Chan Zuckerberg Biohub Network

@czbiohub

2 years

The Chan Zuckerberg Biohub Network has announced the appointment of Amy E. Herr, internationally recognized bioengineer, CZ Biohub Investigator, and UC Berkeley professor, as Chief Technology Officer. Welcome, Amy!

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Chan Zuckerberg Biohub Network

@czbiohub

3 months

Mark your 🗓️! #CZBiohubSF & @ChanZuckerberg will be co-organizing "Cell Biology @ Scale" on March 28. This scientific workshop will focus on achieving large-scale cell biology across experimental scales. Learn more & register ⤵️

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Chan Zuckerberg Biohub Network

@czbiohub

6 years

Announcement: 1st peer-reviewed research from our Cell Atlas initiative: Tabula Muris. A single-cell mouse atlas of 100k cells from 20 organs and a rich data set of cell types and gene expression patterns. Read the @nature paper: #CellAtlas #OpenAccess

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Chan Zuckerberg Biohub Network

@czbiohub

3 years

In our latest Tabula contribution, we share a single-cell transcriptomic atlas of the mouse lemur, comprising data from >220,000 single cells representing >750 defined cell types from 27 organs: the Tabula Microcebus. Explore the data: Learn more (1/4)

Tabula Microcebus

Mouse lemur (Microcebus murinus) transcriptome reference at single cell resolution.

tabula-microcebus.ds.czbiohub.org

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Chan Zuckerberg Biohub Network

@czbiohub

4 years

Today in @nature : Tabula Muris Senis, 1st single-cell aging cell atlas. An #opensource ref dataset of aging-related molecular changes in cells from diff mouse tissues + bio-molecular gold mine for researchers. The work is a Biohub, @Stanford + @UCSF collab

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Chan Zuckerberg Biohub Network

@czbiohub

2 years

The molecular basis of the #autoimmune condition #GravesDisease has been a mystery for decades. Now in @Nature , a collab btwn the @ucsf labs of Biohub Investigator @AashishManglik & @yifan_ucsf has finally solved it. 1/7

Autoantibody mimicry of hormone action at the thyrotropin receptor

Nature - Cryo-electron microscopy structures of the thyrotropin receptor reveal the basis for the activation of the receptor by autoantibodies in patients with Graves’ disease.

www.nature.com

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Chan Zuckerberg Biohub Network

@czbiohub

5 years

New on @biorxivpreprint - Mapping Vector Field of Single Cells - a collab between @Xiaojie_Qiu J. Weissman's lab @UCSF , Xing Lab @jhxing001 , and @czbiohub for predicting cell fate over long-time range instead of short time velocity estimates #RNAVelocity

Mapping Vector Field of Single Cells

Understanding how gene expression in single cells progress over time is vital for revealing the mechanisms governing cell fate transitions. RNA velocity, which infers immediate changes in gene...

www.biorxiv.org

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Chan Zuckerberg Biohub Network

@czbiohub

9 months

🔊Join us at #CZBiohubSF on Oct. 12 for the 2nd #PhysicsofLife Symposium. Register to attend, present a poster, or submit an abstract (especially students, postdocs, and early-career researchers)! Learn more:

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Chan Zuckerberg Biohub Network

@czbiohub

1 year

Meet @ShanaOKelley . She’s launched four biomedical companies, and now leads the new CZ Biohub in Chicago as it aims to unlock the mysteries of inflammation and the human immune system. Learn more about Kelley and her ambitious goals for #CZBiohubCHI :

High Risk, High Reward: Shana Kelley on Building a New Biohub - CZ Biohub

Although Shana Kelley has started four companies, in each case her goal as a founding scientist was to get them set up, hand them off to a CEO, and get

www.czbiohub.org

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Chan Zuckerberg Biohub Network

@czbiohub

2 years

📢 Today, @ChanZuckerberg announced the formation of the CZ Biohub Network! Building off of the success & lessons from CZ Biohub's work, the CZ Biohub Network will give universities & institutions the ability to create new Biohubs to pursue and solve grand scientific challenges.

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Chan Zuckerberg Biohub Network

@czbiohub

5 months

Today at #CellBio2023 get a demo of our @napari_imaging plugin for quantitative label-free imaging with #CZBiohubSF Computational Microscopy team @mattersoflight 📅 12:30-3:30 pm ET, Booth #710

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Chan Zuckerberg Biohub Network

@czbiohub

2 years

All smiles representing Biohub at the Single-Cell Genomics @GordonConf in Switzerland! @loicaroyer , @drAOPisco , @AshleyMaynard10 , Bob Jones, @LeonettiManuel , and @StephenQuake are attending to discuss & promote single-cell solutions to biomedical problems.

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Chan Zuckerberg Biohub Network

@czbiohub

1 year

The #PhysicsofLife opened with a fascinating keynote by biophysicist Stephan Grill about how the laws of physics apply to living matter structuring itself into molecules, cells, & tissues. Tune in now to hear other talks.

Physics of Life 2023 - CZ Biohub Network

Find details and register for The Physics of Life Symposium. Join us in San Francisco or attend virtually to help us build this community!

www.czbiohub.org

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Chan Zuckerberg Biohub Network

@czbiohub

3 years

In our latest Tabula contribution, we are proud to have participated in the creation of the fully open-source Tabula Drosophilae, a single-cell transcriptomic atlas of gene expression in the model organism Drosophila melanogaster, the fruit fly. 1/6

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Chan Zuckerberg Biohub Network

@czbiohub

8 months

Save the date! Join us Jan. 12 at #CZBiohubSF for a full day of discussions, demos & workshops on the latest technological advancements in understanding cell dynamics in #zebrafish 🐟, our favorite model organism. Learn more:

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Chan Zuckerberg Biohub Network

@czbiohub

3 years

CZ Biohub Investigators Tom Nowakowski of @UCSF & Katie Pollard of @GladstoneInst & colleagues used scATAC-seq for epigenomic analysis of the developing human forebrain and cerebral organoids.

Single-cell epigenomics reveals mechanisms of human cortical development

Nature - Analysis of chromatin state at a single-cell level in samples of developing human forebrain demonstrate both cell-type-specific and region-specific changes during neurogenesis.

www.nature.com

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Chan Zuckerberg Biohub Network

@czbiohub

1 year

Therapeutic #antibodies , the fastest growing drug class, can treat #cancer , #autoimmune diseases, and more. @Stanford / #CZBiohubSF researchers are helping to create those treatments even faster, leveraging the #AI technology that brought us #ChatGPT .

Learning to ‘speak amino acid’: How language models can change our approach to medicine - CZ Biohub

In the last year, artificial intelligence–based language models, like the now-famous ChatGPT, have made a splash in the public consciousness. Such

www.czbiohub.org

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Chan Zuckerberg Biohub Network

@czbiohub

4 years

🎉 Congrats to @euanashley , who was appointed to @AstraZeneca ’s board as a non-executive director + a member of its science committee. Dr. Ashley is a Biohub Intercampus Research Awards Project Leader + Associate Dean and Prof of Cardiovascular Medicine and Genetics at @Stanford

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Chan Zuckerberg Biohub Network

@czbiohub

4 years

A newly-formed partnership between @czbiohub , @ChanZuckerberg , @UCSF and @CAgovernor aims to increase local #COVID19 testing to 1,000 tests per day within the coming days thru operational support, informatics and protocol development

New Partnerships Expand COVID-19 Clinical Testing

CZI, CZ Biohub & UCSF partner to expand local testing, aiming for 1,000 tests a day

chanzuckerberg.com

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Chan Zuckerberg Biohub Network

@czbiohub

6 years

Chan Zuckerberg Biohub is celebrating its 2nd anniversary with the 'Beyond the Cell Atlas Conference' Program details and live streaming here: Sponsored by the @czbiohub with support from @cziscience 9/24-9/25, 9 a.m.-6 p.m.

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Chan Zuckerberg Biohub Network

@czbiohub

2 years

Single-cell RNAseq is a powerful tool for telling us what’s inside cells and tissues at the molecular level, but we still need to know *where* things are in the cell. 🧵 1/9

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Chan Zuckerberg Biohub Network

@czbiohub

1 year

Led by @ShanaOKelley , #CZBiohubCHI will focus on technologies to make precise molecular-level measurements of biological processes in human tissues, w/ a goal of understanding the inflammatory states underlying many diseases.

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Chan Zuckerberg Biohub Network

@czbiohub

2 months

📢Announcing the first-ever Chicago BioEngineering Conference! #CZBiohubCHI will bring together scientists in advanced sensing technologies, tissue & cell engineering, new omics approaches, and more. Don't miss it: Sept 30-Oct 1. (1/2) Learn more ⤵️

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Chan Zuckerberg Biohub Network

@czbiohub

4 years

. @nature interviewed Biohub's @olgabot about #openscience tools she used while writing a scientific manuscript. She used open-source software approaches and even tweeted @ reviewers of the paper. What tools do you use when drafting in-progress papers?

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Chan Zuckerberg Biohub Network

@czbiohub

5 years

Calling @Stanford and @UCSF med residents with a passion for research: #CZBiohub Physician-Scientist Fellowship Program offers a new track for young MDs to pursue clinical or basic research training & expand potential for scientific discovery. Learn more:

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Chan Zuckerberg Biohub Network

@czbiohub

11 months

Excited to welcome new Scientific Advisory Board members – @IainCheeseman , @brittaspen , @HarmitMalik , Phil Smoot, and Liliana Solnica-Krezel – joining Peter Kim on the #CZBiohubSF SAB.

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Chan Zuckerberg Biohub Network

@czbiohub

4 years

🎉 Congratulations to Steve Quake, CZ Biohub co-president, for being listed on @NatureBiotech 's Top 20 translational researchers of 2019 list, which is based on a researcher's 🧪Total patents granted in 2019 🧪Top-cited patent over 5 years 🧪H-index (impact of published work)

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@czbiohub

2 years

This week in @naturemethods , Biohub's @loicaroyer lab presents DaXi, a new light-sheet microscope that's cheaper to produce and provides: ✅ Wider view & high-res images ✅ Fast imaging w/o compromising quality ✅ High-throughput imaging Check it out:

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@czbiohub

1 year

Our 11 new physician-scientists from @UCSFMedicine & @StanfordMed will gain experience in scientific research to uncover the #biology behind diseases ranging from gliomas to preeclampsia. Welcome to #BiohubSF ! Learn more:

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Chan Zuckerberg Biohub Network

@czbiohub

5 years

Steve Quake, co-president of CZ Biohub, and his team discovered a Cas9 protein from the hot springs that can remove unwanted cDNA with exceptional thermostability. The IgnaviCas9 protein is active at up to 100 °C in vitro.

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@czbiohub

6 years

Tabula Muris -- A single-cell mouse atlas of 100k cells from 20 organs and a rich data set of cell types and gene expression patterns. Read the @nature paper: #CellAtlas #OpenAccess @spyros_darmanis

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@czbiohub

4 years

In "8 crazy days" Emily Crawford led a team of scientists from Biohub and @UCSF in an effort to transform a research lab into a clinical diagnostics lab to increase #COVID19 testing capacity in California. Check out the story via @BrynMawrAlum Bulletin

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@czbiohub

4 months

"I can’t wait to see what we will discover next . . . 'Looking' at cells is a central pillar of cell biology. I will bet that cells are not done surprising us." 🔬 #CZBiohubSF 's @LeonettiManuel in @CellCellPress 's 50th anniversary issue.

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Chan Zuckerberg Biohub Network

@czbiohub

4 years

Biohub + @Stanford published a paper in @nature today describing what genes change w/age, at the bulk tissue level, across 23 tissues and organs. The research helps bridge #singlecell insights with more traditional approaches to genomic analysis

Ageing hallmarks exhibit organ-specific temporal signatures

Nature - Bulk RNA sequencing of organs and plasma proteomics at different ages across the mouse lifespan is integrated with data from the Tabula Muris Senis, a transcriptomic atlas of ageing mouse...

www.nature.com

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Chan Zuckerberg Biohub Network

@czbiohub

4 years

Go behind the scenes w/ @Bloomberg on how #CZBiohub co-president Joe DeRisi & 200 scientist volunteers built a #COVID19 testing lab in a few days. The lab can process 2500 tests a day w/ genome sequencing to study tiny mutations & transmission of the virus

The Covid Test Lab That Could Save America

The leader of the Chan Zuckerberg Biohub solved a snake pandemic. Now he’s trying to solve the U.S.’s coronavirus testing problem.

www.bloomberg.com

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Chan Zuckerberg Biohub Network

@czbiohub

4 years

Congratulations to Jennifer A. Doudna ( @doudna_lab ), @UCBerkeley professor and Biohub Presidents’ Advisory Board member, for winning the 2020 Nobel Prize in Chemistry

The Nobel Prize

@NobelPrize

4 years

BREAKING NEWS: The 2020 #NobelPrize in Chemistry has been awarded to Emmanuelle Charpentier and Jennifer A. Doudna “for the development of a method for genome editing.”

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@czbiohub

5 years

Earlier this month, our partners at @ChanZuckerberg joined us for lab tours and a lunch & learn conversation. Scientists shared leading-edge research and employees heard from CZI Co-Founders, Priscilla Chan and Mark Zuckerberg, during a Q&A moderated by Co-President Joe DeRisi.

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@czbiohub

1 year

New preprint proposes that the shingles vaccine may prevent about 1 in 5 cases of dementia. Live discussion on impact + limitations from lead author & Biohub Investigator @PGeldsetzer1 with Joe DeRisi, president of #CZBiohubSF @czbiohub at 4 pm PT. Spaces link to come.

Pascal Geldsetzer

@PGeldsetzer1

1 year

Biggest thing to ever come out of my little group. Pls help spread this finding! We found clean, CAUSAL evidence that the shingles vaccine prevents a good chunk of dementia cases. So, could a virus cause Alzheimer’s->YES! Hear me out & see preprint: 🧵1/

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1 month

What a day! Cell Biology @ Scale 2024 was jam-packed with ideas for advancing the research community and tackling the field’s biggest challenges. 1/3 Co-hosts: #CZBiohubSF & @ChanZuckerberg Check out the speaker line-up:

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@czbiohub

1 year

Join us at CZ Biohub for the Physics of Life Symposium! Explore the phenomena of life through the tools, approaches, and style of inquiry of physics with the physical biology community in SF. Register today for #PhysicsOfLife :

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@czbiohub

4 months

The Biohub model "brings together universities and scientists into groups aimed at accomplishing the high goal of curing disease. … This model promises big results … " writes @NatureBiotech . We couldn't agree more!

Nature Biotechnology

@NatureBiotech

4 months

Tearing up the traditional biotech playbook

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@czbiohub

5 years

In October, we brought together leading scientists advancing theory, models & computation to present at 2019 Beyond the Cell Atlas Conference. If you missed the livestream or want to rewatch one of these terrific talks, check out the youtube playlist here:

Beyond The Cell Atlas 2019

A two-day symposium on frontiers in cell biology. Learn more: https://www.czbiohub.org/events/beyond-the-cell-atlas-2019/

www.youtube.com

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Chan Zuckerberg Biohub Network

@czbiohub

4 years

Next-generation sequencing and analysis enable teams at @UCSF and CZ Biohub to draw a clearer picture of how COVID-19 spreads through communities. Read more about it via @bopinion

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@czbiohub

1 year

It’s been great to have @ShanaOKelley , new head of #CZBiohubCHI , visiting #CZBiohubSF all week. She shared her wildly ambitious plans for the CZ Biohub in Chicago and got to see the SF Biohub model up close. Get ready for 🎆.

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Chan Zuckerberg Biohub Network

@czbiohub

5 years

Tabula Muris Senis is a single cell transcriptomic atlas across a mouse's life span that reveals new molecular info on aging. Check out the @biorxivpreprint paper by co-President Steve Quake, @drAOPisco @spyros_darmanis and the Tabula Muris Consortium

A Single Cell Transcriptomic Atlas Characterizes Aging Tissues in the Mouse

Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death [1][1]. Despite rapid advances over recent years [2][2],...

www.biorxiv.org

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Chan Zuckerberg Biohub Network

@czbiohub

4 years

A @gatesfoundation Grand Challenges team from Cambodia assembled the Covid-19 genome using IDseq, a Biohub & @cziscience tool designed to track emerging pathogens. Read the @WIRED story to learn how the tool is helping trace the spread of the #coronavirus

A Disease Tracker Backed by Gates and Zuckerberg Tackles Covid-19

The two tech titans funded an effort to bring metagenomic sequencing and software to poor countries. Now, it’s helping trace the spread of the new coronavirus.

www.wired.com

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Chan Zuckerberg Biohub Network

@czbiohub

5 years

Pumped for our 1st #Neuroengineering Symposium on 4/19! Neural signals, hardware to gather them, algorithms to decode them & everything in between w/ thought leaders from @Stanford @UCSF @UCBerkeley ! Oh & it's live streamed! 📹 Link + schedule out soon😎 #BiohubNeuroESymposium

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@czbiohub

5 years

Don't miss the livestream of the Beyond the Cell Atlas conference today and tomorrow. Scientists will present the latest in theory, models & computation. Full schedule and livestream available on the event page:

Beyond the Cell Atlas 2019 - CZ Biohub Network

Learn about Beyond the Cell Atlas, a two-day symposium on frontiers in cell biology. Sponsored by the Chan Zuckerberg Biohub.

www.czbiohub.org

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@czbiohub

1 year

Check out our #opensource automation of fluorescence-activated cell sorting (FACS), which eliminates operator errors and can cut hands-on time by 93%, enabling truly high-throughput #cellbiology ! Read the preprint: (1/2)

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@czbiohub

3 years

Disease-modifying therapies that target immunometabolic pathways hold promise for a range of chronic diseases. Matthew Spitzer and @UCSFhealth defined metabolic hallmarks of T cell differentiation at the single-cell level. See their work in @CellPressNews :

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Chan Zuckerberg Biohub Network

@czbiohub

4 years

Tabula Muris Senis is the first single-cell aging cell atlas and #opensource reference dataset revealing molecular changes related to aging in cells from diverse mouse tissues. The work is a collaboration between Biohub, @Stanford + @UCSF

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@czbiohub

2 years

New preprint from @stanford / @czbiohub lays out a novel strategy for creating biologic therapies against SARS-CoV-2 that can overcome new variants. Most monoclonal antibodies fail against Omicron bc they target sites on the spike protein that can be easily mutated, here in 🟫. 1/5

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@czbiohub

4 years

It's #NationalEngineersWeek and we’re recognizing the Biohub’s bioengineering team. These talented engineers have expertise in a wide range of areas and build novel tools that allow scientists to explore new frontiers in biology and infectious disease #eWeek2020 #STEM

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@czbiohub

10 months

Our #zebrafish embryos were ready for their close-up! Check out these light-sheet glamor shots from @loicaroyer / @Merlin_Lange ! In the same @naturemethods issue, Royer offers a Comment on how #AI will transform bioimaging analysis, as seen with his own #OmegaAgent .

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Chan Zuckerberg Biohub Network

@czbiohub

4 years

How do scientists map the architecture of a human cell? @LeonettiManuel , group leader of #CZBiohub Cell Atlas Initiative, talks about the different approaches used to study cellular architecture on @iBiology

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Chan Zuckerberg Biohub Network

@czbiohub

2 years

Our MERFISH spatial transcriptomics dataset, created in collaboraton with @vizgen_inc and @UCSF , is now available via the Resources page on our website, along with many other useful open-source tools. See the quoted thread for more on MERFISH.

Chan Zuckerberg Biohub Network

@czbiohub

2 years

Single-cell RNAseq is a powerful tool for telling us what’s inside cells and tissues at the molecular level, but we still need to know *where* things are in the cell. 🧵 1/9

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Chan Zuckerberg Biohub Network

@czbiohub

1 year

The standard diagnostic method for #malaria is time-consuming & error-prone. Our BioE team created what could be a faster, cheaper, & more accurate tool: a UV 🔬 equipped w/ machine learning. We're excited to start field tests with @UCSF & @IDRC_Uganda !

Seeing malaria in a new light - CZ Biohub

CZ Biohub’s Bioengineering team sends custom microscopes to Uganda to test out a new approach to diagnose malaria

www.czbiohub.org

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Chan Zuckerberg Biohub Network

@czbiohub

2 months

Very cool new work from #CZBiohubSF Investigator @james_y_zou and colleagues!

James Zou

@james_y_zou

2 months

🧪🤖 Super excited to share Synthemol: a #genAI that not only designs new molecule drugs but tells us how to build each molecule in lab. It designed 6 novel antibiotics that we synthesized in Ukraine and experimentally validated @NatMachIntell 🧵

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Chan Zuckerberg Biohub Network

@czbiohub

4 years

"The whole society loses if girls and women don't become scientists and innovators. We need fresh perspectives on how to solve the biomedical challenges we're facing and we just can't afford to leave out half of the potential." Senior Data Scientist @drAOPisco #WomeninScienceDay

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Chan Zuckerberg Biohub Network

@czbiohub

4 years

The Bay Area has one of the highest per capita #COVID19 testing rates on the planet - how can that be achieved more broadly? Steve Quake, Biohub co-president, shares his take on what's needed to close the testing gap with other countries.

How much coronavirus testing is enough?

There is a lot of concern that the United States is lagging in testing for COVID. And while some of that concern is justified, I think…

medium.com

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Chan Zuckerberg Biohub Network

@czbiohub

1 year

As we wind up another exciting year of scientific research & collaboration, we wish you & your family a restful, enjoyable holiday break. See you in the new year!

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Chan Zuckerberg Biohub Network

@czbiohub

5 years

Next week, 24 researchers from around the world will be at #CZBiohub to share cutting-edge tech & research re: adaptive immune responses. Livestream the Advances in Immune Repertoire Measurement and Analysis conference 1/23-1/24:

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Chan Zuckerberg Biohub Network

@czbiohub

1 year

For #WomensHistoryMonth @slschmid_CZB is honoring Barbara Pearse of @MRC_LMB . Her discovery of the protein clathrin ignited a field of research that continues to this day: understanding how cells eat, drink, & communicate with each other thru a process called endocytosis.

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Chan Zuckerberg Biohub Network

@czbiohub

11 months

New in @NatureChemistry from @KelleyLabs : Pro-SELEX, a platform for rapid, quantitative aptamer discovery, generates candidates for diverse biosensing applications, with programmable binding affinities spanning a 20-fold range. #CZBiohubChi

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Chan Zuckerberg Biohub Network

@czbiohub

3 years

In a trio of preprints, the Stanford lab of Biohub Investigator @Prakashlab describes experiments and theory to show that in the headless (brainless!) animal Trichoplax adhaerens, ciliated cells can generate forces to walk--and in large cellular sheets, they flock like birds 1/3

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Chan Zuckerberg Biohub Network

@czbiohub

3 years

Tabula Muris Senis is the first #singlecell aging cell atlas and #opensource reference dataset revealing molecular changes related to aging in cells from diverse mouse tissues. The work is a collaboration between CZ Biohub, @Stanford and @UCSF

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Chan Zuckerberg Biohub Network

@czbiohub

11 months

New in @ScienceMagazine , the Aging Fly Cell Atlas maps 868K single-nucleus transcriptomes at multiple time points across the #Drosophila lifespan. All data freely available at

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Chan Zuckerberg Biohub Network

@czbiohub

2 years

Check out Aydin, a new #OpenSource image denoising tool from @loicaroyer lab at CZ Biohub! The user-friendly tool provides a number of self-supervised, auto-tuned, & unsupervised image denoising algorithms.

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Chan Zuckerberg Biohub Network

@czbiohub

3 years

💥Published today in @NatureComms - By profiling gene expression in nasal swabs from #COVID19 tests, Biohub + @UCSF researchers found attenuated activation of innate immune and pro-inflammatory pathways early in the disease versus other viral infections (1/2)

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Chan Zuckerberg Biohub Network

@czbiohub

2 years

“Sepsis is one of the top 10 public health issues facing humanity,” says Chaz Langelier. Scientists at @UCSF , @ChanZuckerberg & Biohub used #MachineLearning & genomic sequencing to create a remarkably accurate diagnostic tool. @WorldSepsisDay

Machine Learning Enables ‘Almost Perfect’ Diagnosis of an Elusive Global Killer

Sepsis diagnostic tool combines genomic sequencing with analysis of patients’ immune response for remarkable accuracy

www.czbiohub.org

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Chan Zuckerberg Biohub Network

@czbiohub

1 year

At #AAASmtg , AAAS President @GildaBarabino sat down with @ChanZuckerberg Head of Science @StephenQuake for an engaging discussion of the role of philanthropy in fueling research and innovation.

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Chan Zuckerberg Biohub Network

@czbiohub

4 years

In a major #COVID19 testing effort in the Mission District, 2% of 4000 residents tested were positive + 90% w/positive results were unable to WFH under shelter in place. Biohub Investigator @bgreenhouse1 from @UCSF helped lead the effort. Learn more ➡️

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Chan Zuckerberg Biohub Network

@czbiohub

4 years

Join Co-President Joe DeRisi and Mark Zuckerberg this morning at 9 a.m. PT for a Facebook Live conversation about COVID-19 and the efforts of @ChanZuckerberg and @czbiohub to respond to the outbreak:

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Chan Zuckerberg Biohub Network

@czbiohub

2 years

A new study out of CZ Biohub and @UCSF finds that the BinaxNOW™ rapid antigen test detects most infectious Omicron cases, performing about as well as with previous variants. Read more in the @NYTimes :

The Abbott BinaxNOW, a rapid antigen test, identified 95 percent of people carrying high levels of the virus, researchers found.

www.nytimes.com

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Chan Zuckerberg Biohub Network

@czbiohub

4 years

EchoNet-Dynamic is the 1st video-based, #deeplearning #algorithm to assess cardiac function and dysfunction. Developed by Biohub Investigator @james_y_zou , the AI algorithm may lay the foundation for precise diagnosis of cardiomyopathies in real-time

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Chan Zuckerberg Biohub Network

@czbiohub

2 years

Congratulations to @LeonettiManuel for receiving the @ASCBiology Innovation in Research Award, especially for his work on #OpenCell ! OpenCell is mapping human proteins one by one, paving a new way to visualize cellular architecture.

American Society for Cell Biology

@ASCBiology

2 years

For his research innovation that significantly impacts progress in advancing the field of cell biology Manuel Leonetti of the Chan Zuckerberg Biohub will receive ASCB’ Innovation in Research Award #OpenCell Congratulations! @czbiohub @LeonettiManuel

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Chan Zuckerberg Biohub Network

@czbiohub

2 years

Amid questions about the ability of rapid antigen tests to reliably detect infection w/ #Omicron , a new analysis on @medrxivpreprint from CZ Biohub and @UCSF shows that the BinaxNOW™ test detects Omicron with a sensitivity similar to that observed for prior variants. (1/3)

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Chan Zuckerberg Biohub Network

@czbiohub

2 years

A new study in @SciImmunology shows that pre-existing autoantibodies to type 1 interferons slow the immune response in breakthrough COVID-19 cases. Before vaccines, these antibodies were found in 10% of patients in the ICU for COVID. Now, they're present in ~25%.

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