Science Immunology @SciImmunology Twitter profile

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Science Immunology

17 days

Science #Immunology ’s April issue is now out! The cover spotlights #CoVLP , a promising plant-based #COVID19 vaccine. CoVLP combined with the adjuvant AS03 could promote progressive maturation of #memory #BCell responses over time.

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Science Immunology

@SciImmunology

2 years

A new study from @VirusesImmunity , @YaleMed , @kaistpr , and @IcahnMountSinai finds that nasal #immunization is superior to injected immunization at producing mucosal lung IgA antibodies, protecting mice from #influenza .

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Science Immunology

@SciImmunology

2 years

“The prospect of achieving [containment of #SARSCoV2 ] with nasal vaccines is high, but will only be possible with dedicated funding, priority, and breaking down of any regulatory hurdles,” write @EricTopol and @VirusesImmunity in a new Editorial.

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Science Immunology

@SciImmunology

8 months

Dendritic cells can “self-shape” the chemotactic gradients that help them transport antigens to lymph nodes, finds a new live imaging study from @Sixt_Lab @EdouardHannezo . 📄: Focus by @hannahdonnelly_ @EMandrou @robinsall :

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Science Immunology

@SciImmunology

2 years

Studying ~56 million T cells from 55 COVID patients, researchers offer a high-res picture of epitope reactivity and TCR usage in CD8 T cells specific for #SARSCoV2 , some of which also react to “common cold” coronaviruses. @RepertoireIM

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Science Immunology

@SciImmunology

1 month

A 2022 Review by @EgleKvedaraite and @FGinhoux contextualizes over five decades of research on #DendriticCells and their roles in #cancer . Catch up on the work: #WeekendReads

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Science Immunology

@SciImmunology

2 years

Human #DendriticCells need a unified nomenclature, write @EgleKvedaraite and @FGinhoux in a Review that summarizes 50 years of dendritic cell research and their functions in #cancer . 📎:

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Science Immunology

@SciImmunology

2 years

The June issue of Science #Immunology is out! The cover spotlights two studies that examine how #RNA exosomes influence #Bcell development and dysfunction. More here➡️

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Science Immunology

@SciImmunology

5 years

We'll be LIVE in less than an hour! In the meantime, check out this video from Sin-Hyeog Im, whose paper on the #probiotic Bifidobacterium bifidum appeared in the 19 October issue, and whose research will be discussed in out chat at 11 ET! Full vid here:

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Science Immunology

@SciImmunology

2 years

A Review by @EgleKvedaraite and @FGinhoux contextualizes over 5 decades of research on #DendriticCells and their roles in cancer, which has been propelled forward by single-cell technologies ➡️

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Science Immunology

@SciImmunology

3 years

New work from @DonnaFarber3 @profshanecrotty labs shows that #SARSCoV2 -specific memory T and B cells persist in tissues months after infection and recovery in unvaccinated people—especially in the lungs and associated lymph nodes.

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Science Immunology

@SciImmunology

2 years

A new Editorial by @EricTopol and @VirusesImmunity calls for an accelerated initiative for nasal vaccination against #SARSCoV2 to support #immunity in the respiratory mucosa.

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Science Immunology

@SciImmunology

3 years

Memory B cells (mostly IgM+IgD+ and IgG1+) for #SARSCoV2 S and N proteins are more stable in blood than #antibody levels for up to 8 mos. after #COVID19 . New #Bmem tetramer data from #vanZelmlab @ImmunologyMU @CCSMonash @emmye1984 #openaccess Link:

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Science Immunology

@SciImmunology

1 year

The April cover of Science #Immunology is out! This month, a study describes the developmental lineage of T follicular regulatory cells isolated from human tonsils. Other pieces examine macrophages behind fibrosis and neoantigens for cancer vaccines.

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Science Immunology

@SciImmunology

2 years

Intracellular complement signaling in human and mouse #macrophages controls inflammatory response in #atherosclerosis models, a new study reports.

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Science Immunology

@SciImmunology

3 years

The new October issue of Science #Immunology is out! In this issue, researchers find that pre-existing killer T cells may enhance checkpoint blockade #cancer #immunotherapy ; and that targeting white fat macrophages prevents #obesity in mice. More to come:

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Science Immunology

@SciImmunology

2 months

A 2022 Review characterizes the ways TGF-β interacts with regulatory T cells, especially in the context of disease. Learn more: #WeekendReads

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Science Immunology

@SciImmunology

5 months

Intracellular complement signaling in human and mouse #macrophages controls inflammatory response in #atherosclerosis models, a 2021 study reported. 📄: #WeekendReads

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Science Immunology

@SciImmunology

9 months

Tumor draining lymph nodes actively remodel in response to tumor growth to directly contribute to immunosuppression and metastasis, argued @theLundLab @nyugrossman @nyulangone in a 2021 Review. #WeekendReads

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Science Immunology

@SciImmunology

2 years

Targeting pathogenic CD4 #Tcells with CAR T cell therapy reverses the progression of multiple sclerosis-like disease in mice, finds new research from @WUSTL @MS_ResearchDoc . 📄:

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Science Immunology

@SciImmunology

1 year

The May cover of Science #Immunology is out! This month, a study explores how crosstalk between myeloid cells and lung epithelial cells could prevent asthma in people with allergies. Other pieces explore STING-agonist nanoparticles for immunotherapy.

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Science Immunology

@SciImmunology

2 years

A new Review explores the role of CD4+ resident memory #Tcells in protection against and pathology of disease, exploring the population’s influence during #infection and #cancer 🔀

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Science Immunology

@SciImmunology

10 months

The July issue of Science #Immunology is out! This month's cover explores how chromatin topology aids memory recall by human memory T helper 2 cells. Other work features antigen presenting tumor cells and assesses immunosuppression from radiotherapy.

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Science Immunology

@SciImmunology

5 months

During treatments to deplete regulatory T cells, conventional T cells that express IL-10 can step in and assume immunosuppressive qualities that continue to obstruct immunotherapeutic success, finds a new study in mice. @SarahKWhiteside

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Science Immunology

@SciImmunology

2 years

A study finds a lack of neutralizing antibodies, #Bcells , and #Tcells against #SARSCoV2 variants of concern, such as BA1.1, in vaccinated people’s lungs, showing intranasal boosters in mice induce lung immunity. @Jie_Immunology @ImmunologyTang @ShanLuLiu1

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Science Immunology

@SciImmunology

2 years

A new study in mice suggests that a majority of IgA in the gut is selected to recognize and react to distinct gut bacterial species instead of demonstrating polyspecificity. @IcahnMountSinai @jeremiahfaith1

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Science Immunology

@SciImmunology

4 months

Patrolling resident memory T cells generate their own biophysical forces that help them travel to pathogenic intruders in the salivary glands of mice, a new study by @joseimmuno and colleagues finds. @unifr 📄:

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Science Immunology

@SciImmunology

6 years

. @ljiresearch scientists uncover the origins of powerful and mysterious cells that fight #dengue , #HIV and more...

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Science Immunology

@SciImmunology

3 years

The new May cover of #Science #Immunology is out! In this issue, read about gut repair programs and how inflammasomes may promote the success of radiation therapy for #cancer . More to come here ...

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Science Immunology

@SciImmunology

2 years

The April issue of Science #Immunology is out! The cover article defines how #Tcell proximity can influence #cancer #immunotherapy outcomes in #melanoma tumors. Other work explores how T cells recruit #Bcells in such contexts. Read more ➡️

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Science Immunology

@SciImmunology

11 months

Urinary tract infections (UTIs) reoccur easily, in part, because resident memory T (TRM) cells are slow to establish immune memory, finds a new study in mice. @ImmunoBladder @institutpasteur

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Science Immunology

@SciImmunology

8 months

Science #Immunology 's September issue is out! The cover features insights into dendritic cells' chemotactic migration, while other work parses the ins-and-outs of T cell exhaustion. Read more:

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Science Immunology

@SciImmunology

2 years

New research explores what happens to resident alveolar macrophages in the lungs of mice following influenza infection. @ETH_en @UZH_en ➡️

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Science Immunology

@SciImmunology

2 months

“Apart from the acute illness caused by #SARSCoV2 , it is now clear that a substantial proportion of patients develop long-term sequelae [damage] after #COVID19 ,” say the authors of a 2022 Review. Learn more on #LongCovidAwarenessDay : #LongCOVID

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Science Immunology

@SciImmunology

7 months

T cell exhaustion is an immunological state that can appear during cancer. ICYMI: This recent Review described recent findings on how exhausted T cells develop and insights into how the state might be treated. #WorldCancerResearchDay

Science Immunology

@SciImmunology

8 months

A new Review contextualizes what is known about the developmental trajectory of T cell exhaustion—a state that arises during cancer and chronic infections. @lan_xlan7 @CaitlinZebley @StJudeResearch

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Science Immunology

@SciImmunology

8 months

Scientists identified a macrophage target in white fat that, when deleted in mice, stunted weight gain, reduced inflammation, and overall protected the animals against #obesity and associated health conditions. @nyugrossman @ufrj 📄: #WeekendReads

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Science Immunology

@SciImmunology

1 month

Inflammatory #cytokines help increase the efficiency of human #fibroblast to #DendriticCell reprogramming by 190-fold. Check out the 2022 study: #WeekendReads

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Science Immunology

@SciImmunology

3 years

In mouse models of lung #cancer , scientists have identified a reservoir of killer T cells in the tumor draining lymph nodes, which evade termination driven by cues in the unforgiving #tumor microenvironment. @YaleMed

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Science Immunology

@SciImmunology

3 years

A 5-month analysis of 254 #COVID19 patients spanning a wide range of disease severity – from asymptomatic to deadly illness – suggests that IgA and IgM antibodies to #SARSCoV2 disappear quickly during convalescence.

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Science Immunology

@SciImmunology

3 months

A new study describes how some CD4 T cells can exhibit killer behavior against melanoma, more closely resembling their cousins, CD8 T cells. @egbawden Learn more:

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Science Immunology

@SciImmunology

2 years

In a new review, researchers look for ways to uncouple anti-tumor and autoimmunity effects of PD-1 #CheckpointBlockadeTherapy .

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Science Immunology

@SciImmunology

2 years

Cerebrospinal fluid #macrophages are a distinct population from #microglia and border associated macrophages, proposes a new Review.

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Science Immunology

@SciImmunology

1 year

Scientists mapped the different stages of maturation for human T follicular helper and T follicular regulatory cells, which aid B cell development: #WeekendReads @medicina_lisboa @ULisboa_ @immolecular

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Science Immunology

@SciImmunology

6 months

By mapping interactions with chromatin loops in mice, scientists from @harvardmed showed how the transcription factor FoxP3 directly regulates the expression of key regulatory T cell genes. Check out the 2022 study: #WeekendReads

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Science Immunology

@SciImmunology

1 year

The December issue of Science #Immunology is out! The cover study spotlights an IL-2 mutein that is more tolerant of the acidic tumor environment, improving immunotherapy in mice with melanoma. Other work presents a mRNA flu vaccine strategy.

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Science Immunology

@SciImmunology

3 years

The new August issue of Science #Immunology is out! Check out new research on differences of the caspase enzyme among dogs, cats, and humans, and how virtual memory T cells act as a bridge between innate and adaptive #immune systems:

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Science Immunology

@SciImmunology

1 year

Tcf1, a “master regulator” of T cell development and #immune responses, may hold the key to new treatments of diseases, from #autoimmunity to #cancer . Learn more in this 2020 Review: @BrighamWomens

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Science Immunology

@SciImmunology

3 years

Scientists have found that autoantibodies that neutralize type I interferons accounted for ~20% of critical #COVID19 cases in individuals >80 years old, as well as more than 20% of deaths in infected patients of all ages. @InstitutImagine @RockefellerUniv

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Science Immunology

@SciImmunology

5 years

Tissue resident memory #Tcells changed the understanding of adaptive #immunology when they were first discovered. Scientists from @ColumbiaMed , @CCTI_NYC provide an extensive review of what we know so far about these elusive cells:

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Science Immunology

@SciImmunology

2 years

#Tcells aren’t necessary for #Bcells as they initiate cyclic re-entry in the #GerminalCenter , signaling a paradigm shift for understanding affinity maturation.

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Science Immunology

@SciImmunology

7 months

Unexpected findings in wildling mice challenge a popular idea that allergies emerge from overreactive and bored immune systems without sufficient exposure to microbiota, due to today’s strict hygienic practices. @SRosshart

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Science Immunology

@SciImmunology

4 years

ICYMI: @WUSTLmed scientists showed that an #immune cell subset in the gut, called group 3 innate lymphoid cells, requires the #circadian clock to better sense and interact with surrounding gut #microbes :

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Science Immunology

@SciImmunology

2 years

BioNTech/Pfizer’s mRNA vaccine induced long-lived memory T cell response for 6 months in 71 vaccinated Italian adults, according to recent research.

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Science Immunology

@SciImmunology

2 months

A 2022 Research Resource identifies more than 300 disease risk #gene variants dependent on activated CD4 #TCells . Learn more: #WeekendReads

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Science Immunology

@SciImmunology

11 months

Deficiency of IgA antibodies influences how well the immune system can maintain control of intestinal bacteria, finds new study involving pediatric patients with varying IgA levels. @henricksonlab @LabSilverman

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Science Immunology

@SciImmunology

2 years

By mapping interactions with chromatin loops in mice, scientists from @harvardmed show how the transcription factor FoxP3 directly regulates the expression of key regulatory T cell genes.

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Science Immunology

@SciImmunology

2 years

A new Review by @MoreauJoshua , @Treg_Mike and @Zihai characterizes the ways TGF-β interacts with regulatory T cells, especially in the context of disease.

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Science Immunology

@SciImmunology

2 months

A 2022 Research Resource identifies more than 300 disease risk #gene variants dependent on activated CD4 T cells. Learn more: #WeekendReads

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Science Immunology

@SciImmunology

2 years

The new November issue of Science #Immunology is out! In this issue, researchers report loss of XIAP impairs Paneth cells leading to IBD; and show how lung cDC progenitors are recruited during flu. More to come:

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Science Immunology

@SciImmunology

4 years

According to a new Perspective, 9 studies – some published, others available as preprints – exemplify the need to investigate T cell responses to #COVID19 to fully understand population-level immunity to the #SARSCoV2 virus.

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Science Immunology

@SciImmunology

11 months

The June issue of Science #Immunology is out! This month's cover features an analysis of tumor TRM cell characteristics in mice. Other studies looked at GAS-responsive T cells and psoriasis, as well as immune cell “neighborhoods” in the skin:

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Science Immunology

@SciImmunology

4 years

ICYMI: A study of #Tcells from patients infected with #HIV shows that a transcription factor known to drive T cell exhaustion in mice might not play the same role in humans. From @marcus_buggert and colleagues at @CIM_Sweden , @karolinskainst : #immunology

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Science Immunology

@SciImmunology

10 months

Tumor cells are infamously skilled masters of immune disguise, but research from @CellReproLab shows that forcing them to present antigens can boost anti-cancer immune activity. @lunduniversity

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Science Immunology

@SciImmunology

2 years

IL-9 contributes to #asthma and #airway_inflammation by promoting interstitial #macrophage responses that support recruitment of #eosinophils according to new research.

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Science Immunology

@SciImmunology

5 months

Researchers found that CD4 T cells from mouse and human infants show enhanced TCR signaling in response to low antigen doses, supporting induction of early life immunity to viral infection. Read the 2021 paper: @DonnaFarber3 @ColumbiaMed #WeekendReads

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Science Immunology

@SciImmunology

5 months

Growing evidence shows tuft cells are important producers of leukotrienes, lipid moderators of type 2 immune responses. Read more in this Focus article from 2022: #WeekendReads

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Science Immunology

@SciImmunology

20 days

In a new Review, scientists discuss how resident tissue #macrophages go beyond immunity to keep organs thriving. @ragoninstitute @HHMINEWS

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Science Immunology

@SciImmunology

8 months

Science #Immunology is thrilled to welcome Seth Scanlon ( @ImmunoEditor ) as Editor. Seth comes to the journal from @ScienceMagazine , where he handled the journal’s immunology research content.

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Science Immunology

@SciImmunology

2 years

New study in mice suggests that light zone #Bcells don’t need #Tcells to initiate cyclic re-entry, challenging a decades-old doctrine.

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Science Immunology

@SciImmunology

3 months

The February issue of Science #Immunology is now out! The cover depicts #CRISPR -Cas9 technology repairing faulty memory #TCells as seen in a disease called hemophagocytic lymphohistiocytosis. Other work includes mapping nasal #TuftCells , and more.

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Science Immunology

@SciImmunology

1 month

A rare group of epithelial cells in the gut provides a reservoir for norovirus infection by resisting local killer T cell activity, finds a new study in mice.

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Science Immunology

@SciImmunology

1 year

Anti-PD-L1 therapy may have limited success in certain cancers because it unleashes the immunosuppressive capacity of regulatory T cells, a new study from @erasmusmcintl finds in mice.

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Science Immunology

@SciImmunology

3 years

. @TheDohertyInst , @AlfredHealth , @MonashUni scientists now have a clearer picture of how T cells discriminate between self-antigen and foreign antigens, highlighting the role of NK cell receptors in helping T cells fight #viruses and prevent #autoimmunity :

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Science Immunology

@SciImmunology

2 months

New research in mice finds that neonatal CD8+ T cells can undergo rapid chromatin remodeling, which supports their innate-like functions. Read more: @Cornell @CornellCFI

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Science Immunology

@SciImmunology

5 months

By identifying the “origins” of stem-like cancer-killing T cells, a 2021 @YaleMed study may help inform efforts to convert cold tumors into hot tumors that are more responsive to checkpoint blockade immunotherapy. #WeekendReads

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Science Immunology

@SciImmunology

4 months

New studies explore how systemic lupus erythematosus pathology develops, revealing how mutations in human UNC93B1 lead to TLR7 hyperactivation and autoimmunity. 📄: @tudresden_de 📄: @_HarshitaMishra @MajerOlivia @mpiib_berlin

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Science Immunology

@SciImmunology

4 years

The new April issue of Science #Immunology is out! Learn about the adaptability of tissue resident memory #Tcells , and more to come. Wondering what's on the cover? Read more in the online cover caption here:

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Science Immunology

@SciImmunology

26 days

A 2022 Review explores the role of CD4+ resident memory #Tcells in protection against and pathology of disease, exploring the population’s influence during #infection and #cancer . Check it out here: #WeekendReads

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Science Immunology

@SciImmunology

7 months

A new study describes why newborn mice—and, possibly, newborn mammals in general—are more susceptible to viral infections in their central nervous systems. @gou_koh 📄:

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Science Immunology

@SciImmunology

2 months

T cells aren’t necessary for B cells as they initiate cyclic re-entry in the #GerminalCenter , signaling a paradigm shift for understanding affinity maturation. Check out the study from 2022: #WeekendReads

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Science Immunology

@SciImmunology

2 months

The ability to produce Interleukin-2 (IL-2) contributes to an increase in effector CD8 #TCells ’ protective powers. Learn more in the 2022 study: #WeekendReads

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Science Immunology

@SciImmunology

3 years

A new method developed by @DanaFarber , @broadinstitute scientists @meyersonlab , @mnleeee identifies specific #antigen parts, or epitopes, among peptide pools – akin to finding needles in a haystack: #immunology

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Science Immunology

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1 year

The February issue of Science #Immunology is out! The cover features insights from two new studies that explore how recurrent TE-exon splicing junctions could be potentially used to improve #cancer immunotherapies:

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Science Immunology

@SciImmunology

8 months

A new Review contextualizes what is known about the developmental trajectory of T cell exhaustion—a state that arises during cancer and chronic infections. @lan_xlan7 @CaitlinZebley @StJudeResearch

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Science Immunology

@SciImmunology

5 months

Researchers from @UofT discovered three subsets of macrophages in mice with unique life cycles and origins residing in multiple tissues. Check out the 2022 study: #WeekendReads

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Science Immunology

@SciImmunology

2 years

Manipulating the way TGF-β interacts with regulatory T cells to develop disease therapies will be a goal for future research, predict @MoreauJoshua , @Treg_Mike and @Zihai in a new Review.

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Science Immunology

@SciImmunology

1 year

During immune homeostasis, dendritic cells become tolerogenic in the spleen by consuming cholesterol from apoptotic cells or lipid nanoparticles, new research by @Victor_Bosteels @JanssensLab in mice finds. Read more:

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Science Immunology

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2 years

New study finds 24% of 42 doubly mRNA vaccinated patients with breakthrough #COVID19 with severe pneumonia had autoantibodies neutralizing type I IFN, suggesting these autoantibodies are a key player in life-threatening breakthroughs. @casanova_lab

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Science Immunology

@SciImmunology

3 months

A new #nanoparticle design selectively activates the innate #DNA -sensing #cGAS - #STING pathway in conventional type I #DendriticCells to boost anti- #tumor activity. @JinmingGaoLab Learn more:

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1 year

In two 2021 studies, @UniSpitalBasel @MayoClinicSOM researchers identified a hybrid T cell subset in the lungs of mice that shows how bodies could protect against new #flu strains after experiencing one. Learn more: #WeekendReads

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Science Immunology

@SciImmunology

3 years

Examining 1,202 male patients with critical #COVID19 #pneumonia , many of which were fatal cases, researchers have identified sex-linked genetic mutations in TLR7 that may contribute to male-biased prevalence of severe #COVID19 . @INSERM @RockefellerUniv

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2 years

October's Science #Immunology issue is out! The cover study uses CAR T cell therapy to regulate self-reactive #Tcells , preventing onset and reversing progression of #MultipleSclerosis -like disease in mice. Other work examines immunity in fatty tissues.

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Science Immunology

@SciImmunology

2 years

A new Review highlights how circadian rhythms control #immunity , spotlighting circadian control of #macrophages , #neutrophils , and cells of the #adaptive immune system:

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Science Immunology

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3 months

Don’t miss this Review from 2021, where researchers look for ways to uncouple anti-tumor and autoimmunity effects of PD-1 #CheckpointBlockadeTherapy . #WeekendReads

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Science Immunology

@SciImmunology

3 years

The new April issue of #Science #Immunology is out! This week, learn all about dendritic cells (in red, below), as two separate studies clarify what regulates their differentiation and how they recognize viruses. More to come:

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Science Immunology

@SciImmunology

2 years

For the weekend, read how @KessenbrockLab at @UCIrvine used mouse models of breast #cancer to uncover new biomarkers and detect an elusive type of cell used by cancer cells to undermine immune responses. ➡️

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5 months

Scientists have tracked a precursor cell population for the adaptive immune system’s stem-like memory T cells, informing the rigorous debate surrounding these T cells’ enigmatic origins. @unil @ISBSIB 📄:

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Science Immunology

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5 months

A subset of natural killer cells—innate immune cells once thought to lack immune memory—can, in fact, remember and react to antigens from HIV-1 and influenza viruses in humans. @BIDMChealth @DukeMedSchool 📄:

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Science Immunology

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4 months

The first Science #Immunology issue of the year is here! The January cover depicts research on gut immune cell migration. Other studies spotlight the LITAF protein and the relationship between regulatory T cells and hair follicle stem cells.

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Science Immunology

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5 months

The December issue of Science #Immunology is out! The cover spotlights the recent discovery of germinal center-like structures in teleost fish spleens. Other work in mice discusses repurposing RNA virus-sensing pathways for immunotherapy. Read more:

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Science Immunology

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3 years

A new @CIM_Sweden , @karolinskainst study of samples collected from patients before the #COVID19 pandemic reveals: killer #Tcells capable of recognizing #SARSCoV2 —despite never having encountered the virus before—reside in tissues, not blood.

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