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Science Translational Medicine

@ScienceTM

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The mission of Science Translational Medicine (AAAS) is to promote human health by communicating leading research and policy in biomedicine.

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Joined February 2011
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@ScienceTM
Science Translational Medicine
6 days
Two decades of dengue surveillance reveal how different serotypes shape the risk of severe disease, colorful brain microdisplays could minimize the risk of tissue damage during neurosurgery, and more in the new issue of #ScienceTranslationalMedicine .
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@ScienceTM
Science Translational Medicine
4 years
A new hydrogel formulation for healing #gastriculcers matches the effectiveness of standard drugs in pigs, and shows ultrafast gelation and superior adhesion compared with standard hydrogels. #biomaterials @CUHKofficial
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@ScienceTM
Science Translational Medicine
3 years
Antibodies generated in response to vaccination could target a broader range of #SARSCoV2 RBD epitopes than those resulting from infection, reveals a new study of #COVID19 patients who received the Moderna mRNA #vaccine : @fredhutch @UW
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Science Translational Medicine
3 years
New studies of mice and data from patients with #BladderCancer and #LungCancer show that #floxacin antibiotics can suppress both chemotherapy resistance and tumor metastasis, two major causes of cancer relapse and mortality. @ImperialSandC
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@ScienceTM
Science Translational Medicine
1 year
This week's new issue of Science Translational Medicine has arrived! A malaria vaccine shows signs of protection in a two-part clinical trial in Burkina Faso, research in mice reveals why green light therapy can relieve pain, and more.
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@ScienceTM
Science Translational Medicine
4 years
This animation describes how new drug combinations can boost the number of beta cells in the pancreas, leading to better control of #diabetes in mice transplanted with human beta cells. Check out the original study: @ScienceVisuals
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@ScienceTM
Science Translational Medicine
2 months
This week's new issue of Science Translational Medicine has arrived! A synthetic antibody against deadly snake venoms takes a step toward a "universal" antivenom, a novel antibacterial compound suppresses a dangerous cousin of M. tuberculosis, and more.
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@ScienceTM
Science Translational Medicine
3 years
Scientists at @nuigalway have created an injectable hydrogel that improves heart function, reduces tissue damage, and encourages the regrowth of blood vessels in a sheep model of #HeartAttack .
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@ScienceTM
Science Translational Medicine
2 years
Don't miss this week's new issue of Science Translational Medicine!
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@ScienceTM
Science Translational Medicine
5 years
This animation shows how a naïve T cell is primed in the lymph node before traveling to the tumor. Although T cells can become exhausted, they can be revived by checkpoint immunotherapy, which prompts cell expansion and differentiation. @ScienceVisuals
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@ScienceTM
Science Translational Medicine
1 year
This week's new issue of Science Translational Medicine has arrived! An immune analysis could inform the next generation of RSV vaccines, researchers explore the roots of long-term smell loss after COVID-19, and more.
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@ScienceTM
Science Translational Medicine
2 years
Oral and intranasal #COVID19 vaccine candidates reduce disease severity and #SARSCoV2 transmission in hamsters and elicit mucosal antibody responses in healthy volunteers, shows a new study from @stephanielangel , Tucker, and colleagues at @DukeSurgery .
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Science Translational Medicine
6 months
This week, Anthony Fauci argues that the world must heed the harsh lessons learned from the #COVID19 pandemic—for both scientific research and public health strategy—to prepare for the inevitable emergence of the next #pandemic pathogen. @gumedcenter
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Science Translational Medicine
4 months
Don't miss this week's new issue of #ScienceTranslationalMedicine ! Rat experiments reveal how rapid-acting antidepressants such as ketamine target negative biases, a cell atlas maps out how fetal and maternal cells interact during labor, and more.
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@ScienceTM
Science Translational Medicine
3 months
This week's new issue of #ScienceTranslationalMedicine has arrived! Researchers uncover stealthy immune saboteurs that drive allergic memory in humans, a new analysis in mice reveals how the brain recovers after stroke, and more.
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@ScienceTM
Science Translational Medicine
1 year
A new special issue in Science Translational Medicine highlights recent advances in cancer immunotherapy, while also looking ahead to future developments on the horizon.
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@ScienceTM
Science Translational Medicine
2 years
In a new Viewpoint, Kavelaars ( @akavel ) and Heijnen ( @cobiheijnen ) assess the dual, sometimes conflicting roles of the #ImmuneSystem in regulating #pain , noting that T cells and macrophages can be either friends or foes depending on the specific context.
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@ScienceTM
Science Translational Medicine
4 years
Researchers have discovered a new species of insect-specific virus that serves as a safe and flexible platform for developing vaccines and diagnostics for #flaviviruses such as West Nile and Zika. @UQ_News #InfectiousDisease #GlobalHealth
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Science Translational Medicine
3 years
A new interdisciplinary study unveils novel insights into the mutational dynamics and transmission properties of #SARSCoV2 in Austria, an early hub of transmission within Europe. @CeMM_News @abergthaler @Alex_M_Popa #Coronavirus
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Science Translational Medicine
3 years
Pooled #SARSCoV2 testing can identify more cases than individual tests in a given budget, a study projects. The results suggest pooling may help address surveillance gaps in low-resource regions. @broadinstitute @michaelmina_lab
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@ScienceTM
Science Translational Medicine
3 years
Scientists at @CCLRI report a new antibiotic secreted by the commensal skin bacterium #Cutibacterium acnes that shapes the skin #microbiome by outcompeting disease-linked Staphylococcus in skin hair follicles. @mfgrp
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@ScienceTM
Science Translational Medicine
2 years
This week's new issue of Science Translational Medicine has arrived!
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@ScienceTM
Science Translational Medicine
11 months
Researchers tie endometriosis in women to an invasive genus of bacteria, fecal microbiome transplants may soothe colitis during cancer immunotherapy, and more in this week's issue of #ScienceTranslationalMedicine .
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@ScienceTM
Science Translational Medicine
4 years
A research team has designed a bispecific antibody that binds #cancer cell proteins on one side and the T cell receptor CD28 on its other side, and can enhance the antitumor properties of other bispecific antibodies for CD3 in mice. @Regeneron
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@ScienceTM
Science Translational Medicine
4 years
The Jaklenec and Langer labs have created heat-stable microparticles that can preserve, protect and deliver multiple micronutrients such as iron to rodents and human volunteers. @kochinstitute
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@ScienceTM
Science Translational Medicine
7 months
Don't miss this week's new issue of #ScienceTranslationalMedicine ! A clinical trial tests a cell therapy to prevent liver transplant rejections, a "chemoprevention" gel may help prevent a common skin cancer, and more.
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@ScienceTM
Science Translational Medicine
1 year
Don't miss this week's new issue of Science Translational Medicine! Studies show that a ketogenic diet may help combat low platelet counts during chemotherapy, a topical contraceptive blocks sperm entry in large animals, and more.
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@ScienceTM
Science Translational Medicine
10 months
A pair of vaccines for the malaria parasite P. vivax show promise in early trials, COVID vaccine boosters can help bridge gaps in vaccine immunity in the immunocompromised, and more in this week's issue of #ScienceTranslationalMedicine .
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@ScienceTM
Science Translational Medicine
2 years
A newly identified monoclonal antibody can broadly protect mice from SARS-CoV, #SARSCoV2 , and multiple pre-emergent bat coronaviruses, shows research from @David_RMartinez and the @Baric_Lab , @lab_haynes , and Acharya lab at @UNC and @TheDHVI . #COVID19
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@ScienceTM
Science Translational Medicine
3 years
Scientists at @EmoryMedicine have redesigned an oncolytic adenovirus to avoid being trapped in the liver by IgM antibodies, addressing an obstacle that has limited the safety and efficacy of these viruses as treatments for metastatic #cancer .
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@ScienceTM
Science Translational Medicine
2 years
An #mRNA vaccine that induces “tick immunity” prevents black-legged #ticks from properly feeding and slows the transmission of #LymeDisease in guinea pigs, according to new experiments from @andaleebsajid and Fikrig at @YaleIMed . #InfectiousDisease
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@ScienceTM
Science Translational Medicine
5 months
In this week's special issue on #obesity systems, an array of articles dives into the latest emerging discoveries in obesity research, including the complex links between obesity and other body systems and breakthroughs in obesity drugs.
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Science Translational Medicine
1 year
The new issue of #ScienceTranslationalMedicine has arrived! Fragment patterns in tumor DNA inform cancer diagnostics, a predictive model may detect small-cell lung cancer, a Report shows catheters can trigger dormant UTIs in mice, and more.
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@ScienceTM
Science Translational Medicine
1 year
Why does PD-1 #immunotherapy sometimes accelerate the progression of #melanoma ? Studying mice and patients, the @hanks_lab identifies an #inflammasome axis that contributes to melanoma metastasis but can be targeted pharmacologically. @DukeCancer
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@ScienceTM
Science Translational Medicine
4 years
The approved anti-malarial drug chloroquine can sensitize drug-resistant strains of #tuberculosis to isoniazid and other first-line antibiotics in rodent models. Check out the new study from @iiscbangalore . #DrugResistance
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Science Translational Medicine
1 year
A large patient study decodes why "hybrid" #COVID19 immunity offers superior protection, high vitamin A intake may guard against pancreatitis during leukemia therapy, and more in this week's issue of #ScienceTranslationalMedicine .
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@ScienceTM
Science Translational Medicine
4 years
By studying 10 different receptor designs for CAR #RegulatoryTCells , researchers have characterized the key biological features of these modified immune cells and their ability to suppress graft-versus-host disease in mice. @mklevings @BCCHresearch #GVHD
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@ScienceTM
Science Translational Medicine
7 months
The new special issue on zoonotic diseases has arrived! Articles this week explore the latest research and counterstrategies for zoonotic threats, including an Editorial from Anthony Fauci and research on how the skin microbiome influences leishmaniasis.
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@ScienceTM
Science Translational Medicine
2 years
This week's new issue of Science Translational Medicine has arrived!
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@ScienceTM
Science Translational Medicine
3 years
A study with patient samples and a new cellular model may help explain why patients with severe #COVID19 or bacterial #sepsis both show similar changes in immunity, such as spikes in immune-suppressing myeloid cells. @broadinstitute
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@ScienceTM
Science Translational Medicine
1 year
A vaccine for #chikungunya based on virus-like particles induces strong responses in humans and generates neutralizing antibodies that protect mice against multiple #alphaviruses , shows an analysis of a phase 2 trial from @msdiamondlab . @wusm_pathology
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Science Translational Medicine
2 years
This week's new issue of Science Translational Medicine has arrived!
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@ScienceTM
Science Translational Medicine
4 years
By redirecting #checkpointblockade treatments into lymph nodes and other locoregional sites surrounding tumors, the Thomas lab has made these treatments both safer and more powerful against #melanoma and breast cancer in mice. @GeorgiaTech #immunotherapy
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@ScienceTM
Science Translational Medicine
2 years
The new issue of Science Translational Medicine has arrived!
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@ScienceTM
Science Translational Medicine
5 years
A better way to deliver insulin? Artificial pancreas systems could streamline the treatment of #type1diabetes , say researchers in our third #10thanniversary Focus @MRC_Epid
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@ScienceTM
Science Translational Medicine
1 year
A treatment prevents deadly peanut allergy reactions in mice, a compound can extend the shelf life of donor hearts, research in Kenya unravels natural killer cell immunity against malaria, and more in the new issue of #ScienceTranslationalMedicine .
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@ScienceTM
Science Translational Medicine
2 years
The new issue of Science Translational Medicine has arrived!
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@ScienceTM
Science Translational Medicine
4 years
How exactly does abnormal #tau protein drive #Alzheimers disease? New research implicates an RNA-binding protein as a contributor to the neurodegeneration induced by this protein. @VAPugetSound
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@ScienceTM
Science Translational Medicine
3 months
The new issue of #ScienceTranslationalMedicine is out now!  Transplants of lung stem cells for COPD prove safe in an early clinical trial, a new generation of adoptive #Tcells shows promise against refractory multiple myeloma in mice, and more.
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@ScienceTM
Science Translational Medicine
6 months
In this week’s #neuroimmunology special issue, Thai and @PratLab explore advances in immune cell carriers that ferry therapeutics across the #BloodBrainBarrier , which are opening a new frontier in #DrugDelivery for central nervous system disorders. @CRCHUM
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@ScienceTM
Science Translational Medicine
2 years
A high-resolution atlas from @UTDPainLab elucidates the characteristics of pain-sensing neurons and how they differ across species and in between sexes – offering a useful resource in the search for new #pain therapies. @UTDPainCenter #Neurology
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@ScienceTM
Science Translational Medicine
10 months
This week's new issue of #ScienceTranslationalMedicine is here! A large study of middle-aged adults links proteins to dementia risk later in life, phase 1 trial data suggests niconimatide may augment natural killer cell therapy, and more.
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@ScienceTM
Science Translational Medicine
1 year
This year's first issue of #ScienceTranslationalMedicine has arrived!  The evolutionary history of SARS-CoV-2 informs a broadly protective vaccine candidate, an experimental gene therapy for muscular dystrophy shows promise in large animals, and more.
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@ScienceTM
Science Translational Medicine
5 years
An antibody-like treatment from @scrippsresearch provides sustained protection against repeated doses of SIV in animal models, indicating it could potentially help prevent #HIV infection.
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@ScienceTM
Science Translational Medicine
2 years
The Qasim lab at @GreatOrmondSt has engineered universal, “off-the-shelf” #CARTCells that proved safe in a phase 1 trial of pediatric patients with #leukemia , avoiding the need for costly and time-consuming personalization of these therapies.
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@ScienceTM
Science Translational Medicine
9 months
Scientists discover a new connection between glaucoma and gut-homing T cells, an FDA-approved drug sensitizes aggressive lung and prostate tumors in mice, and more in this week's issue of #ScienceTranslationalMedicine .
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@ScienceTM
Science Translational Medicine
2 years
An approved formulation of the vitamin #niacin slows the death of neurons and the progression of #AlzheimersDisease in mice by correcting #microglia , according to new experiments from Moutinho, Landreth, and colleagues at @NeurosciStark . #Neurology
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@ScienceTM
Science Translational Medicine
3 years
Using a new genetic mouse model and MRI imaging in 6 patients, the @CanaudLab at @Univ_Paris and @Inserm has discovered that the approved cancer drug #alpelisib can combat rare genetic disorders known as #lymphaticmalformations .
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@ScienceTM
Science Translational Medicine
2 years
The new issue of Science Translational Medicine is out now! This special issue features research, Reviews, and Viewpoints that investigate the many dimensions of acute and chronic pain, as well as the latest research frontiers in therapies for pain relief.
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@ScienceTM
Science Translational Medicine
1 year
Don't miss this week's issue of #ScienceTranslationalMedicine !  Brain-penetrating antivirals could offer treatments for encephalitis viruses, stealthy pancreatic islet transplants treat diabetes in mice while avoiding autoimmunity, and more.
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@ScienceTM
Science Translational Medicine
2 years
Don't miss this week's new issue of Science Translational Medicine!
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@ScienceTM
Science Translational Medicine
1 year
This week's new issue of #ScienceTranslationalMedicine has arrived!  New research in mice demystifies the connection between sleep loss and Alzheimer's disease, beta-blocker drugs can empower chemotherapy against aggressive breast cancer, and more.
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@ScienceTM
Science Translational Medicine
4 months
The new issue of #ScienceTranslationalMedicine is out! New research in mice reveals that the liver acts as a hub for vaccine immunity against invasive bacteria, common hormones may be major culprits in muscle wasting after spinal cord injuries, and more.
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@ScienceTM
Science Translational Medicine
1 year
Combining CoronaVac ( #SinoVac ) with boosters from other vaccines such as Pfizer and AstraZeneca augments antibody titers against #Omicron and other #SARSCoV2 variants in vaccinees, show the @VirusesImmunity and @carolilucas labs. @mab_sp125
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@ScienceTM
Science Translational Medicine
7 months
Inspired by the suction cups lining an octopus’s tentacles, scientists engineer suction patches for #DrugDelivery that ferry drugs and proteins through the oral mucosa in animals, and prove safe and tolerable in humans. @SUSTechSZ @ETH_en #Biotechnology
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@ScienceTM
Science Translational Medicine
6 months
The new special issue of #ScienceTranslationalMedicine is out! This issue features a collection of studies and articles exploring frontiers in #neuroimmunology and the role of the immune system in neurological conditions such as Parkinson's disease.
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Science Translational Medicine
11 months
A combination therapy for #glioblastoma based on the alkylating agent CCNU and a tumor-seeking fusion protein eradicates “cold” tumors in mice and proves safe in a clinical trial involving 5 patients with this deadly brain #cancer . @UZH_en
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Science Translational Medicine
7 months
An octopus-inspired suction patch delivers hard-to-absorb drugs through the cheeks, scientists uncover two new drivers of severe liver disease and fibrosis, and more this week in #ScienceTranslationalMedicine .
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Science Translational Medicine
4 years
Naturally occurring adeno-associated viral vectors isolated from the human liver may be better choices for liver #GeneTherapy than traditional vectors grown in culture, according to the Lisowsky lab at @CMRI_AUS . #AAV #ViralVectors Credit: L. Lisowski
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Science Translational Medicine
4 years
The new issue of Science Translational Medicine has arrived!
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Science Translational Medicine
11 months
Harnessing structural and functional techniques, researchers identify and optimize a pan #hantavirus antibody that can protect rodents against infections with the evolutionarily distinct Puumala virus & Andes virus. @MittlerEva @Guardado_Calvo @EinsteinMed
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@ScienceTM
Science Translational Medicine
2 months
Transplants of lung progenitor cells are safe in people with #COPD and show early signs of improving lung function and exercise capacity, according to results from a clinical trial involving patients with various stages of the disorder. #TongjiUniversity
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Science Translational Medicine
11 months
This week's new issue of #ScienceTranslationalMedicine has arrived! A gene transfer therapy tested in mice shows promise for treating immune disorders, new research identifies a long-sought link between blood and bone in beta thalassemia, and more.
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@ScienceTM
Science Translational Medicine
2 years
This week's new issue of Science Translational Medicine is out now!
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@ScienceTM
Science Translational Medicine
9 months
A metagenomics study deciphers the connection between the gut microbiome and inflammatory arthritis, a biobank of cancer organoids reveals a potential combination treatment for liver cancer, and more this week in #ScienceTranslationalMedicine .
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@ScienceTM
Science Translational Medicine
20 days
This week's issue of #ScienceTranslationalMedicine is out! A new study suggests that many surgical infections may arise from the patient's own skin microbiome, ultrasoft platelet-like particles staunch traumatic bleeding in large animals, and more.
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@ScienceTM
Science Translational Medicine
3 years
Don't miss this week's new issue of Science Translational Medicine!
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@ScienceTM
Science Translational Medicine
4 years
In a 2017 study, scientists showed that a small molecule was broadly effective against multiple types of #coronavirus , indicating it could be valuable as new viruses emerge in the future. #FromtheArchives #GlobalHealth
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Science Translational Medicine
3 months
Imaging the thickness of the retina may predict the risk of various chronic conditions, a machine learning platform uses repetitive genomic sequences to sniff out early signs of cancer, and more in this week's new issue of #ScienceTranslationalMedicine .
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@ScienceTM
Science Translational Medicine
3 years
This week's new issue of Science Translational Medicine is out now!
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@ScienceTM
Science Translational Medicine
10 months
Don't miss this week's new issue of #ScienceTranslationalMedicine !  A point-of-care HPV test may assist cervical cancer screening in low-resource settings, an automated belt allows scientists to easily study hormone dynamics in people, and more.
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@ScienceTM
Science Translational Medicine
2 years
New experiments from Langston, @MarkRCookson1 , and colleagues reveal that #microglia may explain how noncoding mutations in #LRRK2 raise the risk of #ParkinsonsDisease , despite expressing the gene less than other cell types. @NIHAging @SingletonNeuro
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Science Translational Medicine
1 year
Knocking out the transcription factors #BLIMP1 and #NR4A3 in #CART cells leads to higher #Antitumor activity in mice, shows new research from scientists at @PennMed . Learn more:
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Science Translational Medicine
4 years
The new issue of Science Translational Medicine is out!
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@ScienceTM
Science Translational Medicine
1 year
This week's new issue of #ScienceTranslationalMedicine has arrived! Tumor-infiltrating T cells offer clues about predicting responses to cancer immunotherapy, a study in mice highlights a potential treatment for Parkinson's disease, and more.
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@ScienceTM
Science Translational Medicine
3 years
This week's issue of Science Translational Medicine has arrived!
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@ScienceTM
Science Translational Medicine
3 years
This week's new issue of Science Translational Medicine has arrived!
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Science Translational Medicine
2 years
Don't miss this week's new issue of Science Translational Medicine!
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@ScienceTM
Science Translational Medicine
11 months
The new issue of #ScienceTranslationalMedicine has arrived! A large meta-analysis shows that brain stimulation can improve cognition across age groups and medical conditions, a combo therapy for glioblastoma shrinks tumors in mice and humans, and more.
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Science Translational Medicine
2 years
Discoveries about the emotional, motivational, and cognitive circuits that regulate the multidimensional perception of #ChronicPain are informing new treatment and biomarker approaches, say Lindsay ( @7867Mercer ), @GregScherrer25 , @DrSeanMackey , and co.
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Science Translational Medicine
2 years
Don't miss this week's new issue of Science Translational Medicine!
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4 years
The first Focus in our special #10thanniversary series explored advances in microbiome research and the challenges for therapeutic application. @WeizmannScience #ICYMI
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Science Translational Medicine
8 months
An inhaled therapy protects animals from COVID-19 by mimicking the ACE2 receptor, scientists build a new test for Parkinson's based on mitochondrial DNA, and more this week in #ScienceTranslationalMedicine .
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Science Translational Medicine
2 years
This week's new issue of Science Translational Medicine has arrived!
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Science Translational Medicine
8 months
This week's new issue of #ScienceTranslationalMedicine is out! An approved vaccine for respiratory syncytial virus remains effective against distinct viral variants, researchers construct an "atlas" of the complement system during COVID-19, and more.
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Science Translational Medicine
2 years
Despite its past success, the field of #antibiotics must turn to new investments and innovations in alternatives to overcome financial disincentives, drug resistance, and other future challenges. Read more from Cook and @gerryiidr at @McMasterIIDR :
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Science Translational Medicine
1 year
Don't miss this week's issue of #ScienceTranslationalMedicine ! Connectome blueprints reveal how habit-forming brain circuits go awry in binge eating, antiviral antibodies protect large animals from severe yellow fever, and more.
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Science Translational Medicine
3 years
This week's issue of Science Translational Medicine has arrived!
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@ScienceTM
Science Translational Medicine
2 years
This week's new issue of Science Translational Medicine is out now!
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Science Translational Medicine
11 months
The nanoparticle #HIV vaccine candidate eOD-GT8 60mer generates robust vaccine-specific responses from T cells and memory B cell expansion in humans, shows an analysis of a first-in-human phase 1 trial. @fredhutch @IAVI
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Science Translational Medicine
4 years
Taking a step towards a major goal in pediatric heart valve #prosthetics , scientists have created a valve replacement that can be manually expanded to accommodate heart growth in young sheep. @harvardmed @wyssinstitute #PediatricCardiology #Bioengineering
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