Two decades of dengue surveillance reveal how different serotypes shape the risk of severe disease, colorful brain microdisplays could minimize the risk of tissue damage during neurosurgery, and more in the new issue of
#ScienceTranslationalMedicine
.
A new hydrogel formulation for healing
#gastriculcers
matches the effectiveness of standard drugs in pigs, and shows ultrafast gelation and superior adhesion compared with standard hydrogels.
#biomaterials
@CUHKofficial
Antibodies generated in response to vaccination could target a broader range of
#SARSCoV2
RBD epitopes than those resulting from infection, reveals a new study of
#COVID19
patients who received the Moderna mRNA
#vaccine
:
@fredhutch
@UW
New studies of mice and data from patients with
#BladderCancer
and
#LungCancer
show that
#floxacin
antibiotics can suppress both chemotherapy resistance and tumor metastasis, two major causes of cancer relapse and mortality.
@ImperialSandC
This week's new issue of Science Translational Medicine has arrived!
A malaria vaccine shows signs of protection in a two-part clinical trial in Burkina Faso, research in mice reveals why green light therapy can relieve pain, and more.
This animation describes how new drug combinations can boost the number of beta cells in the pancreas, leading to better control of
#diabetes
in mice transplanted with human beta cells. Check out the original study:
@ScienceVisuals
This week's new issue of Science Translational Medicine has arrived!
A synthetic antibody against deadly snake venoms takes a step toward a "universal" antivenom, a novel antibacterial compound suppresses a dangerous cousin of M. tuberculosis, and more.
Scientists at
@nuigalway
have created an injectable hydrogel that improves heart function, reduces tissue damage, and encourages the regrowth of blood vessels in a sheep model of
#HeartAttack
.
This animation shows how a naïve T cell is primed in the lymph node before traveling to the tumor. Although T cells can become exhausted, they can be revived by checkpoint immunotherapy, which prompts cell expansion and differentiation.
@ScienceVisuals
This week's new issue of Science Translational Medicine has arrived!
An immune analysis could inform the next generation of RSV vaccines, researchers explore the roots of long-term smell loss after COVID-19, and more.
Oral and intranasal
#COVID19
vaccine candidates reduce disease severity and
#SARSCoV2
transmission in hamsters and elicit mucosal antibody responses in healthy volunteers, shows a new study from
@stephanielangel
, Tucker, and colleagues at
@DukeSurgery
.
This week, Anthony Fauci argues that the world must heed the harsh lessons learned from the
#COVID19
pandemic—for both scientific research and public health strategy—to prepare for the inevitable emergence of the next
#pandemic
pathogen.
@gumedcenter
Don't miss this week's new issue of
#ScienceTranslationalMedicine
!
Rat experiments reveal how rapid-acting antidepressants such as ketamine target negative biases, a cell atlas maps out how fetal and maternal cells interact during labor, and more.
This week's new issue of
#ScienceTranslationalMedicine
has arrived! Researchers uncover stealthy immune saboteurs that drive allergic memory in humans, a new analysis in mice reveals how the brain recovers after stroke, and more.
A new special issue in Science Translational Medicine highlights recent advances in cancer immunotherapy, while also looking ahead to future developments on the horizon.
In a new Viewpoint, Kavelaars (
@akavel
) and Heijnen (
@cobiheijnen
) assess the dual, sometimes conflicting roles of the
#ImmuneSystem
in regulating
#pain
, noting that T cells and macrophages can be either friends or foes depending on the specific context.
Pooled
#SARSCoV2
testing can identify more cases than individual tests in a given budget, a study projects. The results suggest pooling may help address surveillance gaps in low-resource regions.
@broadinstitute
@michaelmina_lab
Scientists at
@CCLRI
report a new antibiotic secreted by the commensal skin bacterium
#Cutibacterium
acnes that shapes the skin
#microbiome
by outcompeting disease-linked Staphylococcus in skin hair follicles.
@mfgrp
Researchers tie endometriosis in women to an invasive genus of bacteria, fecal microbiome transplants may soothe colitis during cancer immunotherapy, and more in this week's issue of
#ScienceTranslationalMedicine
.
A research team has designed a bispecific antibody that binds
#cancer
cell proteins on one side and the T cell receptor CD28 on its other side, and can enhance the antitumor properties of other bispecific antibodies for CD3 in mice.
@Regeneron
The Jaklenec and Langer labs have created heat-stable microparticles that can preserve, protect and deliver multiple micronutrients such as iron to rodents and human volunteers.
@kochinstitute
Don't miss this week's new issue of
#ScienceTranslationalMedicine
! A clinical trial tests a cell therapy to prevent liver transplant rejections, a "chemoprevention" gel may help prevent a common skin cancer, and more.
Don't miss this week's new issue of Science Translational Medicine!
Studies show that a ketogenic diet may help combat low platelet counts during chemotherapy, a topical contraceptive blocks sperm entry in large animals, and more.
A pair of vaccines for the malaria parasite P. vivax show promise in early trials, COVID vaccine boosters can help bridge gaps in vaccine immunity in the immunocompromised, and more in this week's issue of
#ScienceTranslationalMedicine
.
Scientists at
@EmoryMedicine
have redesigned an oncolytic adenovirus to avoid being trapped in the liver by IgM antibodies, addressing an obstacle that has limited the safety and efficacy of these viruses as treatments for metastatic
#cancer
.
In this week's special issue on
#obesity
systems, an array of articles dives into the latest emerging discoveries in obesity research, including the complex links between obesity and other body systems and breakthroughs in obesity drugs.
The new issue of
#ScienceTranslationalMedicine
has arrived! Fragment patterns in tumor DNA inform cancer diagnostics, a predictive model may detect small-cell lung cancer, a Report shows catheters can trigger dormant UTIs in mice, and more.
The approved anti-malarial drug chloroquine can sensitize drug-resistant strains of
#tuberculosis
to isoniazid and other first-line antibiotics in rodent models. Check out the new study from
@iiscbangalore
.
#DrugResistance
A large patient study decodes why "hybrid"
#COVID19
immunity offers superior protection, high vitamin A intake may guard against pancreatitis during leukemia therapy, and more in this week's issue of
#ScienceTranslationalMedicine
.
By studying 10 different receptor designs for CAR
#RegulatoryTCells
, researchers have characterized the key biological features of these modified immune cells and their ability to suppress graft-versus-host disease in mice.
@mklevings
@BCCHresearch
#GVHD
The new special issue on zoonotic diseases has arrived! Articles this week explore the latest research and counterstrategies for zoonotic threats, including an Editorial from Anthony Fauci and research on how the skin microbiome influences leishmaniasis.
A study with patient samples and a new cellular model may help explain why patients with severe
#COVID19
or bacterial
#sepsis
both show similar changes in immunity, such as spikes in immune-suppressing myeloid cells.
@broadinstitute
A vaccine for
#chikungunya
based on virus-like particles induces strong responses in humans and generates neutralizing antibodies that protect mice against multiple
#alphaviruses
, shows an analysis of a phase 2 trial from
@msdiamondlab
.
@wusm_pathology
By redirecting
#checkpointblockade
treatments into lymph nodes and other locoregional sites surrounding tumors, the Thomas lab has made these treatments both safer and more powerful against
#melanoma
and breast cancer in mice.
@GeorgiaTech
#immunotherapy
A treatment prevents deadly peanut allergy reactions in mice, a compound can extend the shelf life of donor hearts, research in Kenya unravels natural killer cell immunity against malaria, and more in the new issue of
#ScienceTranslationalMedicine
.
How exactly does abnormal
#tau
protein drive
#Alzheimers
disease? New research implicates an RNA-binding protein as a contributor to the neurodegeneration induced by this protein.
@VAPugetSound
The new issue of
#ScienceTranslationalMedicine
is out now!
Transplants of lung stem cells for COPD prove safe in an early clinical trial, a new generation of adoptive
#Tcells
shows promise against refractory multiple myeloma in mice, and more.
A high-resolution atlas from
@UTDPainLab
elucidates the characteristics of pain-sensing neurons and how they differ across species and in between sexes – offering a useful resource in the search for new
#pain
therapies.
@UTDPainCenter
#Neurology
This week's new issue of
#ScienceTranslationalMedicine
is here! A large study of middle-aged adults links proteins to dementia risk later in life, phase 1 trial data suggests niconimatide may augment natural killer cell therapy, and more.
This year's first issue of
#ScienceTranslationalMedicine
has arrived!
The evolutionary history of SARS-CoV-2 informs a broadly protective vaccine candidate, an experimental gene therapy for muscular dystrophy shows promise in large animals, and more.
An antibody-like treatment from
@scrippsresearch
provides sustained protection against repeated doses of SIV in animal models, indicating it could potentially help prevent
#HIV
infection.
The Qasim lab at
@GreatOrmondSt
has engineered universal, “off-the-shelf”
#CARTCells
that proved safe in a phase 1 trial of pediatric patients with
#leukemia
, avoiding the need for costly and time-consuming personalization of these therapies.
Scientists discover a new connection between glaucoma and gut-homing T cells, an FDA-approved drug sensitizes aggressive lung and prostate tumors in mice, and more in this week's issue of
#ScienceTranslationalMedicine
.
The new issue of Science Translational Medicine is out now! This special issue features research, Reviews, and Viewpoints that investigate the many dimensions of acute and chronic pain, as well as the latest research frontiers in therapies for pain relief.
Don't miss this week's issue of
#ScienceTranslationalMedicine
!
Brain-penetrating antivirals could offer treatments for encephalitis viruses, stealthy pancreatic islet transplants treat diabetes in mice while avoiding autoimmunity, and more.
This week's new issue of
#ScienceTranslationalMedicine
has arrived!
New research in mice demystifies the connection between sleep loss and Alzheimer's disease, beta-blocker drugs can empower chemotherapy against aggressive breast cancer, and more.
The new issue of
#ScienceTranslationalMedicine
is out! New research in mice reveals that the liver acts as a hub for vaccine immunity against invasive bacteria, common hormones may be major culprits in muscle wasting after spinal cord injuries, and more.
Inspired by the suction cups lining an octopus’s tentacles, scientists engineer suction patches for
#DrugDelivery
that ferry drugs and proteins through the oral mucosa in animals, and prove safe and tolerable in humans.
@SUSTechSZ
@ETH_en
#Biotechnology
The new special issue of
#ScienceTranslationalMedicine
is out! This issue features a collection of studies and articles exploring frontiers in
#neuroimmunology
and the role of the immune system in neurological conditions such as Parkinson's disease.
A combination therapy for
#glioblastoma
based on the alkylating agent CCNU and a tumor-seeking fusion protein eradicates “cold” tumors in mice and proves safe in a clinical trial involving 5 patients with this deadly brain
#cancer
.
@UZH_en
An octopus-inspired suction patch delivers hard-to-absorb drugs through the cheeks, scientists uncover two new drivers of severe liver disease and fibrosis, and more this week in
#ScienceTranslationalMedicine
.
Naturally occurring adeno-associated viral vectors isolated from the human liver may be better choices for liver
#GeneTherapy
than traditional vectors grown in culture, according to the Lisowsky lab at
@CMRI_AUS
.
#AAV
#ViralVectors
Credit: L. Lisowski
Harnessing structural and functional techniques, researchers identify and optimize a pan
#hantavirus
antibody that can protect rodents against infections with the evolutionarily distinct Puumala virus & Andes virus.
@MittlerEva
@Guardado_Calvo
@EinsteinMed
Transplants of lung progenitor cells are safe in people with
#COPD
and show early signs of improving lung function and exercise capacity, according to results from a clinical trial involving patients with various stages of the disorder.
#TongjiUniversity
This week's new issue of
#ScienceTranslationalMedicine
has arrived!
A gene transfer therapy tested in mice shows promise for treating immune disorders, new research identifies a long-sought link between blood and bone in beta thalassemia, and more.
A metagenomics study deciphers the connection between the gut microbiome and inflammatory arthritis, a biobank of cancer organoids reveals a potential combination treatment for liver cancer, and more this week in
#ScienceTranslationalMedicine
.
This week's issue of
#ScienceTranslationalMedicine
is out!
A new study suggests that many surgical infections may arise from the patient's own skin microbiome, ultrasoft platelet-like particles staunch traumatic bleeding in large animals, and more.
In a 2017 study, scientists showed that a small molecule was broadly effective against multiple types of
#coronavirus
, indicating it could be valuable as new viruses emerge in the future.
#FromtheArchives
#GlobalHealth
Imaging the thickness of the retina may predict the risk of various chronic conditions, a machine learning platform uses repetitive genomic sequences to sniff out early signs of cancer, and more in this week's new issue of
#ScienceTranslationalMedicine
.
Don't miss this week's new issue of
#ScienceTranslationalMedicine
!
A point-of-care HPV test may assist cervical cancer screening in low-resource settings, an automated belt allows scientists to easily study hormone dynamics in people, and more.
This week's new issue of
#ScienceTranslationalMedicine
has arrived! Tumor-infiltrating T cells offer clues about predicting responses to cancer immunotherapy, a study in mice highlights a potential treatment for Parkinson's disease, and more.
The new issue of
#ScienceTranslationalMedicine
has arrived! A large meta-analysis shows that brain stimulation can improve cognition across age groups and medical conditions, a combo therapy for glioblastoma shrinks tumors in mice and humans, and more.
Discoveries about the emotional, motivational, and cognitive circuits that regulate the multidimensional perception of
#ChronicPain
are informing new treatment and biomarker approaches, say Lindsay (
@7867Mercer
),
@GregScherrer25
,
@DrSeanMackey
, and co.
An inhaled therapy protects animals from COVID-19 by mimicking the ACE2 receptor, scientists build a new test for Parkinson's based on mitochondrial DNA, and more this week in
#ScienceTranslationalMedicine
.
This week's new issue of
#ScienceTranslationalMedicine
is out! An approved vaccine for respiratory syncytial virus remains effective against distinct viral variants, researchers construct an "atlas" of the complement system during COVID-19, and more.
Despite its past success, the field of
#antibiotics
must turn to new investments and innovations in alternatives to overcome financial disincentives, drug resistance, and other future challenges. Read more from Cook and
@gerryiidr
at
@McMasterIIDR
:
Don't miss this week's issue of
#ScienceTranslationalMedicine
!
Connectome blueprints reveal how habit-forming brain circuits go awry in binge eating, antiviral antibodies protect large animals from severe yellow fever, and more.
The nanoparticle
#HIV
vaccine candidate eOD-GT8 60mer generates robust vaccine-specific responses from T cells and memory B cell expansion in humans, shows an analysis of a first-in-human phase 1 trial.
@fredhutch
@IAVI