Vijay Sankaran @bloodgenes Twitter profile

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Vijay Sankaran

@bloodgenes

6 months

Remarkable to see that our discoveries over 15 years ago would enable such tremendous advances for sickle cell disease and thalassemia!!! Incredible to think that the final sentence of our 2008 paper would be prophetic ()...

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Vijay Sankaran

@bloodgenes

1 year

Delighted to have our paper, led by @jmartinrufino , on conducting massively parallel base editing screens in primary human hematopoietic cells out in @CellCellPress today. Can help improve therapeutic approaches for #leukemia and #sicklecell disease:

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Vijay Sankaran

@bloodgenes

2 years

Interested in how cellular barcoding can help us better understand and treat human diseases? Please check out this review from @leonard_zon , @JswLab , and I in @ScienceMagazine today:

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Vijay Sankaran

@bloodgenes

3 years

Enjoying Dr. Fauci and #ASH20 at home!

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Vijay Sankaran

@bloodgenes

4 years

Our review on how advances in #genomics have impacted our understanding of #hematopoiesis was published in @CellCellPress today. Grateful to the reviewers and editors for valuable guidance. We tried to cover a lot and apologize for all that we missed:

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Vijay Sankaran

@bloodgenes

2 years

Incredibly honored to receive the 2022 @SocPedResearch E Mead Johnson Award, which many of my mentors and heroes have been prior recipients of! This recognizes the incredible work of past and current lab members, as well as tremendous collaborators and colleagues! 🙏

Dana-Farber/Boston Children's

@DFBC_PedCare

2 years

Congratulations to Vijay Sankaran, MD, PhD, ( @bloodgenes ) on receiving the 2022 E. Mead Johnson Award from @SocPedResearch for his research using human genetic variation to advance our understanding of blood cell production!

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Vijay Sankaran

@bloodgenes

4 months

Fantastic to have our paper "Deciphering cell states and genealogies of human hematopoiesis" published today in @Nature as an Accelerated Article Preview! We describe ReDeeM! Awesome work led by @chenweng1991 in a wonderful collaboration with @JswLab !

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Vijay Sankaran

@bloodgenes

4 months

Wonderful to have our paper, "Inherited blood cancer predisposition through altered transcription elongation", published (open access) in @CellCellPress today! 🧵 (1/n)

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Vijay Sankaran

@bloodgenes

1 year

Really delighted to have our paper led by @ZHAOJiawei9 showing how human hematopoietic stem cells are vulnerable to ferroptosis published in @CellCellPress : 🙏 to our awesome reviewers and editor for helping us improve this work significantly!

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Vijay Sankaran

@bloodgenes

2 years

Are you interested in how we can learn more human biology by integrating #singlecell genomics and #GWAS ? Please check out our preprint: #V2F mapping at single-cell resolution through network propagation Led by @fulong_yu ! A short 🧵 (1/n)

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Vijay Sankaran

@bloodgenes

5 years

Incredibly honored to receive the Lodish Family Chair from @BostonChildrens ! Would not have been possible without the many tremendous trainees, colleagues, and mentors that I have been fortunate to work with! Particularly meaningful that this was given by Pam and Harvey Lodish!

Dana-Farber/Boston Children's

@DFBC_PedCare

5 years

Congratulations to Vijay Sankaran, MD, PhD, who was named the inaugural recipient of the Lodish Family Career Development Chair at @BostonChildrens last month. Learn more about @bloodgenes on our website:

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Vijay Sankaran

@bloodgenes

2 months

Why do Latino children have the highest risk for childhood leukemia in the US? We identify one cause for this in a paper out in @CellGenomics today, led by @adamdesmith , @LWahlster , @SoYoungJeon_Eli , @fulong_yu , @CharlestonCWKC , & colleagues:

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Vijay Sankaran

@bloodgenes

2 years

Really grateful that @ASH_hematology has set up such a fantastic hybrid meeting for #ASH21 , so that we can enjoy this great meeting, even if we are at home!

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Vijay Sankaran

@bloodgenes

2 months

Wonderful to have our paper 'Deciphering cell states and genealogies of human haematopoiesis' led by @chenweng1991 , in a great collaboration with @JswLab , published today in @Nature :

Deciphering cell states and genealogies of human haematopoiesis

Nature - An improved, single-cell lineage-tracing system, based on deep detection of naturally occurring mitochondrial DNA mutations with simultaneous readout of transcriptional states and...

www.nature.com

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Vijay Sankaran

@bloodgenes

4 years

Bit delayed, but delighted to see this study led by members of @SoranzoTeam ( @d__vuckovic , @ParsaAkbari ) and our group ( @erik_bao , @CalebLareau ) with numerous other fantastic colleagues published in @CellCellPress : Even our new tough critic enjoyed it!

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Vijay Sankaran

@bloodgenes

1 year

Wonderful to have our paper on a MECOM-regulated gene network in human hematopoietic stem cell maintenance and leukemia published in @NatImmunol ! Terrific work from our group led by @RichardVoit , @Taoliming , and @fulong_yu :

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Vijay Sankaran

@bloodgenes

1 year

Fortunate to be able to spend such a wonderful evening with close friends, mentors, and colleagues, including several generations of Boston hematology!

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Vijay Sankaran

@bloodgenes

3 years

Wonderful to have our work on using genome editing in single cells to better understand hemoglobin switching published in @NatureComms today. Terrific work by Yong Shen, @JeffreyVerboon , and colleagues from the @JianXuLab and Orkin labs: 👇Short thread

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Vijay Sankaran

@bloodgenes

2 years

Hopefully sharing an office with @KuchrooLab and @soumya_boston will make me less immunologically naïve

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Vijay Sankaran

@bloodgenes

3 years

Very exciting to see these 2 papers in the @NEJM today demonstrating successful targeting of BCL11A to induce fetal hemoglobin to treat #SickleCell disease based off of our fundamental mechanistic studies over a decade ago!

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Vijay Sankaran

@bloodgenes

5 years

Excited to have our paper on using mtDNA mutations for lineage tracing published in @CellCellPress today!!! Fantastic collaboration with Aviv Regev's group led by @LeifLudwig , @CalebLareau , and @julirsch !

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Vijay Sankaran

@bloodgenes

2 years

Delighted to have our pre-print, "A genetic disorder reveals a hematopoietic stem cell regulatory network co-opted in leukemia", led by @RichardVoit , @Taoliming , and @fulong_yu in a great collaboration with #AvivRegev posted on @biorxivpreprint : 🧵👇

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Vijay Sankaran

@bloodgenes

2 years

To maintain lifelong blood production, hematopoietic stem cells have a number of adaptations. What is the impact? We have studied a rare disease to identify one resultant liability: ferroptosis Pre-print: Human HSC vulnerability to ferroptosis 🧵

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Vijay Sankaran

@bloodgenes

4 years

Delighted to have our work on the role of LIN28B in regulating hemoglobin switching by impacting BCL11A translation published in @NatureGenet !: Here is a brief tweetorial of this work from Anindita Basak, @M_Munschauer , @CalebLareau , and others (1/n)

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Vijay Sankaran

@bloodgenes

5 years

Deeply saddened that Sir David Weatherall, who had a profound influence on me starting from when I was a medical student, passed away today. He was the quintessential physician-scientist and his work will continue to have an enormous influence on science and medicine.

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Vijay Sankaran

@bloodgenes

2 years

Today is erythropoiesis day at @BloodJournal ! Our review on erythropoiesis is out: (w/ accompanying excellent reviews from Semenza and Cazzola) Our new GATA1 mutant paper is also out: (w/ great preview: )

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Vijay Sankaran

@bloodgenes

3 years

Terrific to have our latest preprint out in @medrxivpreprint led by the amazing team of @la_liggett , Liam Cato, @J__Stock , and @AlexBickMDPhD : "Clonal hematopoiesis in sickle cell disease" (Thread .. 1/n)

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Vijay Sankaran

@bloodgenes

4 years

Delighted to have this wonderful work led by @erik_bao , @neuron81 , and @xiaotianliao in our laboratory, along with numerous colleagues published in @nature today! Grateful to the reviewers and editors for all of their guidance and feedback!

Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells

Nature - A genome-wide association study identifies 17 genetic loci that are associated with the risk of myeloproliferative neoplasms (MPNs), and shows that the modulation of haematopoietic stem...

www.nature.com

Erik Bao

@erik_bao

4 years

Now online @nature ! Myeloproliferative neoplasms have one of the highest familial risks among cancers, but what drives this? Biobank-level GWAS and functional analyses implicate HSC function. Huge team effort w/ @neuron81 , @xiaotianliao , @bloodgenes 1/n

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Vijay Sankaran

@bloodgenes

1 year

We know that fetal hemoglobin is an important modifier of sickle cell disease and thalassemia. How is it regulated? Please check out our preprint: "Genetic regulation of HbF across global populations" by @liamcato , #RickLi , @realHenryLu , & co: 🧵

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Vijay Sankaran

@bloodgenes

4 years

Delighted to have our work on massively parallel single-cell mitochondrial genotyping and chromatin profiling, led by @CalebLareau and @LeifLudwig in our laboratory, in a wonderful collaboration with Aviv Regev, published in @NatureBiotech :

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Vijay Sankaran

@bloodgenes

3 years

Our report on leukemia predisposition with germline GATA1 mutations that cause Diamond-Blackfan Anemia is out in @BloodJournal : Adds to the recent fascinating findings from @Elvin_Wag & co published in @ScienceMagazine :

Mapping the cellular origin and early evolution of leukemia in Down syndrome

Initiation and progression of leukemogenesis in Down syndrome involves distinct cellular origins and effects of trisomy 21.

www.science.org

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Vijay Sankaran

@bloodgenes

3 years

We all have a low level of circulating CD34+ progenitor cells in our blood. But what underlies variation in amount of such cells? Delighted to contribute to this study from Nilsson and colleagues to define genetic variation underlying CD34 %:

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Vijay Sankaran

@bloodgenes

5 years

Incredibly honored to receive the 2019 Seldin-Smith Award from @the_asci !!! The credit really goes to the amazing trainees in the lab I am fortunate to work with, the fantastic colleagues I am lucky to have, and all of my incredible mentors over the years!

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Vijay Sankaran

@bloodgenes

4 years

A few years ago, we found a pathogenic EPO mutant that was studied in this @CellCellPress paper: Now we are delighted to report that the patient is doing terrific with recombinant EPO tx for > 4 years in this @MedCellPress paper:

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Vijay Sankaran

@bloodgenes

4 years

For those interested in the challenge of going from variant-to-function from #GWAS results or in understanding human hematopoiesis, please check out this review in @TrendsGenetics by @neuron81 and @Xiaotianliao from our group:

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Vijay Sankaran

@bloodgenes

4 years

Such an exciting time: work we began over a decade ago to understand the fundamental biology of hemoglobin switching, which highlighted BCL11A, has now led to multiple promising therapeutic avenues for #SickleCell and #Thalassemia ! @DFBC_PedCare

Andy Biotech

@AndyBiotech

4 years

#ASH19 Here comes another interesting early data for targeting BCL11A in #SickleCell … $BLUE Lentiviral vector encoding shRNA vs. $CRSP $VRTX #CRISPR /Cas9 Gene editing Which approach will be better for SCD?

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Vijay Sankaran

@bloodgenes

3 years

Wow! Learning so much about mutagenesis in hematopoietic stem cells today... Great work from @imartincorena and colleagues from @sangerinstitute in @nature showing how most mutations in blood cells arise in HSCs with single molecule mutation profiling:

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Vijay Sankaran

@bloodgenes

4 years

So proud of @LeifLudwig from our group, who will be starting as a group leader in the coming weeks in Berlin at the @BIMSB_MDC / @MDC_Berlin / @ChariteBerlin !!! Congratulations, Leif!!! So fortunate to be able to work with amazing people like you!

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Vijay Sankaran

@bloodgenes

4 years

Delighted to see this terrific work from @CalebLareau and @LeifLudwig in our group showing how mitochondrial mutations can be used to track clonal mosaicism longitudinally in human hematopoietic cells (in bulk) published in @BloodAdvances :

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Vijay Sankaran

@bloodgenes

5 years

Incredibly gratifying to see the work that we started many years ago, which led to our discovery of BCL11A in hemoglobin switching, now result in curative therapies for sickle cell disease!!! Has taken a considerable effort by many translational colleagues from @ChildCancerCare !

Nicholas Kristof

@NickKristof

5 years

Sickle cell disease affects 100,000 Americans but never gets adequate attention or funding because for genetic reasons it disproportionately affects blacks. Now, finally, there are breakthroughs with gene therapy:

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Vijay Sankaran

@bloodgenes

4 years

Congratulations, @KathleenHBurns !!! So excited to hear that you will be joining the @DanaFarber and @BrighamWomens as Chair of the Department of Oncologic Pathology! Wonderful news and will be terrific to have you in Boston!

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Vijay Sankaran

@bloodgenes

3 years

It is a testament to incredible fundamental and translational science that within a year of the #SARSCoV2 virus being identified to cause #COVID19 , a #vaccine was developed! Grateful to receive the first dose to protect my patients, colleagues, friends, and family! #CovidVaccine

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Vijay Sankaran

@bloodgenes

6 years

Our paper on how ribosome levels affect lineage commitment during human hematopoiesis from @RajKhajur and colleagues (including @julirsch ) is out in @CellCellPress : (1/n)

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Vijay Sankaran

@bloodgenes

26 days

Exciting to see what our discoveries have led to so far!! Lights a 🔥 under us, as well as many other physicians and scientists!

Eric Topol

@EricTopol

26 days

A Welcome to the Era of Genome Editing today @NEJM Overview @G_Q_Daley Casgevy for Sickle-Cell Disease Casgevy for Beta-Thalassemia

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Vijay Sankaran

@bloodgenes

5 months

Great to see my medical school classmate @MarsonLab at #ASH23 @ASH_hematology !!! We both like to read and edit genomes to treat diseases!

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Vijay Sankaran

@bloodgenes

5 years

Fantastic to have our paper on transcriptional and chromatin states in human erythropoiesis led by @LeifLudwig & @CalebLareau with other colleagues in our group and collaborators published in @CellReports today:

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Vijay Sankaran

@bloodgenes

3 years

Delighted to see this fantastic work led by @LWahlster and @JeffreyVerboon identifying a new cause of ANKRD26 related thrombocytopenia due to a complex structural variant published in @JExpMed (open access): (1/n)

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Vijay Sankaran

@bloodgenes

4 months

I am incredibly fortunate to work with this amazing team in our lab at @DFBC_PedCare @BostonChildrens @broadinstitute !!! Wonderful lab dinner last night at MIDA in the South End!

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Vijay Sankaran

@bloodgenes

3 years

@CRISPRchef And in that very same issue of @ScienceMagazine 12 years ago, we identified BCL11A as a regulator of fetal hemoglobin, which has become a key initial target. Little did we know how these and other advances would push forward this basic science discovery. Pretty amazing!

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Vijay Sankaran

@bloodgenes

4 months

Wonderful dinner at Batifol in Cambridge with John Dick from @PMResearch_UHN , @BradEBernstein , @leonard_zon , and @vangalenlab !!

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Vijay Sankaran

@bloodgenes

2 years

Great to see our preprint out examining shared and distinct genetic causes of different types of clonal hematopoiesis! Terrific collaboration with @DerekWBrown_1 , @liamcato , @ZhaoDylan , @jrbperry , @mitchiela :

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Vijay Sankaran

@bloodgenes

8 months

Wonderful to see our collaborative work examining shared and distinct genetic etiologies for different types of clonal hematopoiesis, from @DerekWBrown_1 , @liamcato , @ZhaoDylan , @jrbperry , @mitchiela , and colleagues, published today:

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Vijay Sankaran

@bloodgenes

4 years

Fascinating pre-print in @biorxivpreprint on hematopoiesis in long-lived naked-mole rats: More quiescent HSCs than in mice and no sign of some key hematopoietic TFs like RUNX1, GFI1B, GFI1, etc.

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Vijay Sankaran

@bloodgenes

3 years

So thrilled to learn that @erik_bao from our group received the 2021 Seidman Prize for Outstanding @mit_hst M.D. Student Thesis, named in honor of two people I admire tremendously: Kricket and Jon Seidman. So well deserved! Congratulations, Erik!!!

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Vijay Sankaran

@bloodgenes

5 years

How can we go from variant to function for #GWAS ? Gene-centric functional screens may be one potentially valuable approach (here for human #hematopoiesis )! Proud of this work led by @neuron81 and Sean McFarland, as well as other colleagues in @eLife :

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Vijay Sankaran

@bloodgenes

5 years

Thank you! An incredible honor to receive the #SeldinSmithAward this year and so wonderful to have an introduction by my mentor, David Nathan! #JointMeeting2019

Elyse Dankoski

@elysecdx

5 years

This year's #SeldinSmithAward winner is Vijay Sankaran @bloodgenes , whom David Nathan described as a "walking google." Congratulations on this well-deserved honor!! #JointMeeting2019

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Vijay Sankaran

@bloodgenes

2 years

Sad to miss this in person, but absolutely wonderful to see my mentor Harvey Lodish receive the #ASH21 Wallace H. Coulter Award for Lifetime Achievement in Hematology from @ASH_hematology ! So incredibly well deserved! Fortunate to have met Harvey 15 years ago!

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Vijay Sankaran

@bloodgenes

2 years

Delighted to release a significantly updated version of our pre-print, "Shared and distinct genetic etiologies for different types of clonal hematopoiesis", led by @DerekWBrown_1 , @liamcato , @ZhaoDylan , @jrbperry , @mitchiela on @biorxivpreprint :

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Vijay Sankaran

@bloodgenes

1 year

Incredibly fortunate to work with this tremendous, fun, and diverse group of individuals (and a few others who could not join us) in our lab! Excited for all that we will do together in 2023!

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Vijay Sankaran

@bloodgenes

5 years

Excited to have our preprint out in @biorxivpreprint showing how genetic predisposition for acquiring MPNs modulates hematopoietic stem cell function. Terrific work led by @erik_bao , @neuron81 , @Xiaotianliao , and other fantastic colleagues:

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Vijay Sankaran

@bloodgenes

2 years

Grateful to @NatureGenet for this nice highlight of our recent paper (): Mapping genetic variants to cellular contexts:

Variant to function mapping at single-cell resolution through network propagation

Nature Biotechnology - SCAVENGE identifies causal variants from single-cell epigenomic data.

www.nature.com

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Vijay Sankaran

@bloodgenes

4 years

Delighted to have our study showing how CDC42 dysfunction can cause myelofibrosis published! Terrific work led by @JeffreyVerboon and Dilnar Mahmut in our group, along with great collaborators:

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Vijay Sankaran

@bloodgenes

2 years

I am incredibly fortunate to work with this incredible group (+ a few awesome folks, who could not join us)! As adept on the rock wall as they are at generating and analyzing genomic and functional data!

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Vijay Sankaran

@bloodgenes

2 months

Incredibly delighted that @jmartinrufino and Soumyaa Mazumder from our lab both matched for their pediatrics residencies at the Boston Combined Residency Program ( #BCRP ) at @BostonChildrens and @The_BMC !!! Congratulations!!! The future of pediatrics (+ heme/onc) is very bright!!

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Vijay Sankaran

@bloodgenes

6 years

Truly honored to have received the 2018 #DrukierPrize in Children's Health Research today at @WeillCornell ! Had an absolutely wonderful experience in NY today! I am grateful to the Selection Committee, the Drukier family, and the amazing people at @WeillCornell !

Weill Cornell Medicine

@WeillCornell

6 years

Today: Dr. Vijay Sankaran @bloodgenes , of @harvardstemcell @broadinstitute @BostonChildrens @ChildCancerCare & @DanaFarber , will receive the 2018 #DrukierPrize in Children's Health Research for his research in pediatric hematology & oncology, human genetics, & stem cell biology

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Vijay Sankaran

@bloodgenes

3 years

Amazing study in @nature from @jacob_hanna and colleagues showing ex vivo development of mouse embryos from E5.5 through E11! I wonder if HSCs have started to form in the AGM at the end of this ex vivo period:

Ex utero mouse embryogenesis from pre-gastrulation to late organogenesis

Nature - A new culture system makes it possible to grow mouse embryos and study their development outside the uterus up to the point of late organogenesis.

www.nature.com

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Vijay Sankaran

@bloodgenes

2 years

Grateful to the fantastic editors at the @BostonGlobe and @GlobeIdeas for giving my much better half and I the opportunity to write this op-ed: Can we prevent childhood cancer?

Can we prevent childhood cancer? - The Boston Globe

More effective treatments for childhood cancers are desperately needed. But they shouldn't come at the expense of identifying the root causes.

www.bostonglobe.com

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Vijay Sankaran

@bloodgenes

2 years

Great to be in NYC for the first time since the pandemic started! Excited to see many friends and colleagues tomorrow while visiting @nyulangone !

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Vijay Sankaran

@bloodgenes

2 years

Fantastic day kayaking on the Charles River! I am very lucky to work with this incredible group (and some other awesome folks who were unable to join)!

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Vijay Sankaran

@bloodgenes

4 years

Fortunate to work with fantastic trainees and staff in our @DFBC_PedCare program, as we care for our patients with blood disorders, including observing the many hematologic manifestations of #COVID19 !

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Vijay Sankaran

@bloodgenes

5 years

Thank you, @EricTopol !!! I am incredibly fortunate for all the opportunities I have had to be inspired by patients, trainees, colleagues, and mentors over the years!

Eric Topol

@EricTopol

5 years

How meeting a patient changed a career An inspirational story, by @bloodgenes @NatureMedicine @BostonChildrens @broadinstitute

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Vijay Sankaran

@bloodgenes

5 years

An important perspective on saving the endangered physician-scientist in @NEJM : I am shocked that only ~1.5% of physicians in the workforce are physician-scientists!

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Vijay Sankaran

@bloodgenes

2 years

Excited to have this terrific study - #V2F mapping at #SingleCell resolution through network propagation - led by @fulong_yu along with a fantastic team published in @NatureBiotech : 🙏 Editors/ Reviewers for valuable comments that improved this work

Vijay Sankaran

@bloodgenes

2 years

Are you interested in how we can learn more human biology by integrating #singlecell genomics and #GWAS ? Please check out our preprint: #V2F mapping at single-cell resolution through network propagation Led by @fulong_yu ! A short 🧵 (1/n)

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Vijay Sankaran

@bloodgenes

4 years

@VirusesImmunity @BioRender @ShizAoki Thank you, @VirusesImmunity ! This is valuable! Given this paper in pediatric patients(), incubation time may need to be extended further?

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Vijay Sankaran

@bloodgenes

1 month

Incredibly proud of @RichardVoit who is a recipient of a 2024 @the_asci Emerging-Generation Award!!! Congratulations, Richard!!

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Vijay Sankaran

@bloodgenes

4 months

Check out this awesome 🧵 from @chenweng1991 👇!!!

Chen Weng

@chenweng1991

4 months

Very delighted to share our work Deciphering cell states and genealogies of human hematopoiesis online today in @Nature (Accelerated Preview version). It is a really great collaboration of Weissman lab @JswLab and Sankaran lab @bloodgenes 🧵(1/n)

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Vijay Sankaran

@bloodgenes

4 years

Outstanding review on clonal hematopoiesis from @challenlab and @Goodell_Lab in @BloodJournal :

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Vijay Sankaran

@bloodgenes

2 years

Terrific to see @IdoAmitLab at this fantastic #CoBHumanDev meeting!

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Vijay Sankaran

@bloodgenes

2 years

Wonderful to have our manuscript, "Clonal hematopoiesis in sickle cell disease", from @la_liggett , @liamcato , @J__Stock , @AlexBickMDPhD , and other colleagues, published in the @jclinicalinvest today:

Vijay Sankaran

@bloodgenes

3 years

Terrific to have our latest preprint out in @medrxivpreprint led by the amazing team of @la_liggett , Liam Cato, @J__Stock , and @AlexBickMDPhD : "Clonal hematopoiesis in sickle cell disease" (Thread .. 1/n)

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Vijay Sankaran

@bloodgenes

2 years

Bravo @AlbaRMeira from @AdamMead_Oxford laboratory!!! Terrific talk at #ASH21 plenary revealing how #singlecell multi-omic analyses can reveal how inflammatory interferon signaling can drive TP53 mutant clone expansion in the progression of MPNs to AML!

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Vijay Sankaran

@bloodgenes

5 years

Excited to take part in this upcoming @NatureGenet webcast with Kristen Brennand and Catherine Potenski on the challenges of going from Variant to Function! Please join us if you are interested in these approaches! #GWAS #genetics #Genomics

Nature Genetics

@NatureGenet

5 years

Register now for our webcast Variant to Function with Kristen Brennand and Vijay Sankaran @bloodgenes Nov. 7

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Vijay Sankaran

@bloodgenes

3 years

A bit delayed, but terrific to have our paper from Yong Shen and colleagues examining the functional consequences of BCL11A missense variants on fetal hemoglobin silencing published in @PLOSGenetics :

Pathogenic BCL11A variants provide insights into the mechanisms of human fetal hemoglobin silencing

Author summary Greater production of fetal hemoglobin can ameliorate the severity of the most common genetic disorders that impact the hemoglobin genes, sickle cell disease and β-thalassemia. BCL11A...

journals.plos.org

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Vijay Sankaran

@bloodgenes

4 years

Lucky to work with this amazing team!!! Holiday lab dinner!

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Vijay Sankaran

@bloodgenes

3 years

Incredibly proud of postdoctoral fellow @neuron81 from our group who is becoming an Assistant Professor of Cell Biology at @EinsteinMed and @ae_cancercenter this fall! Congratulations, Satish!!! Can't wait to see the exciting things that will come from the Nandakumar Lab! #newPI

Satish Nandakumar

@neuron81

3 years

I am thrilled to announce that I will join @EinsteinMed @ae_cancercenter as Assistant Professor of Cell Biology this Fall. Grateful for the support from my incredible mentors & colleagues: @bloodgenes @Zfish_Blood_Lab @pnatarajanmd @leonard_zon and @Agarwal_Lab .

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Vijay Sankaran

@bloodgenes

2 years

Had an amazing time speaking (in person) at @kochinstitute & @MITBiology today! Terrific seeing so many incredible folks: @EliezerCalo , @yadirasotof , @fjsanchezrivera , @LabJacks , @MEBirnbaum , @jstraehlaMD , @davidhousmanmit , @mbyaffe , @mvh_lab , & others. Thank you! 🙏

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Vijay Sankaran

@bloodgenes

5 years

In Our Blood: A Profile of Stuart Orkin | The Scientist Magazine®

In Our Blood: A Profile of Stuart Orkin

By unraveling the molecular underpinnings of inherited blood disorders, the Boston Children’s Hospital researcher has provided the basis for therapies now being tested for beta-thalassemia and sickle...

www.the-scientist.com

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Vijay Sankaran

@bloodgenes

2 years

Excited to work with this tremendous team, including @leonard_zon , @ldnotar , and other fantastic colleagues! Thank you, @RUNX1Research ! 🙏

The RUNX1 Research Program

@RUNX1Research

2 years

RRP & @NIH 's @NCIResearchCtr @NIAIDNews @genome_gov & @nih_nhlbi announced that Dr. @leonard_zon , Dr. Luigi Notarangelo & @bloodgenes as the 2022 RiSE Grant recipients for their work to define clonal & metabolic alterations in the evolution of #RUNX1FPD :

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Vijay Sankaran

@bloodgenes

5 years

Our paper on gleaning insights into human hematopoiesis from a rare non-coding GATA1 variant is out in @JExpMed : Fabulous work from Nour Abdulhay, @ClaudiaCla29 , @JeffreyVerboon , @LeifLudwig , @julirsch , @CalebLareau in our group w/ great colleagues!

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Vijay Sankaran

@bloodgenes

19 days

Delighted to have made it to Toronto (after a bit of a delay) and excited to visit @pmcancercentre @UHN tomorrow! Wonderful dinner at Canoe Restaurant with a birds-eye city view with John Dick, Gordon Keller, and Steve Chan! 🙏 @stephxie !

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Vijay Sankaran

@bloodgenes

4 years

Congratulations to @CalebLareau for an awesome defense!!! Looking forward to having you for a couple of more months here in Boston before you head to Palo Alto! 😀

Izzie Fulcher

@isabelfulcher

4 years

Wahoo, Dr. ⁦ @CalebLareau ⁩!!!

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Vijay Sankaran

@bloodgenes

2 years

Terrific lab dinner at @JacksAbby ! I am really lucky to work with this incredible group (and a few folks who sadly had to miss this)!

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Vijay Sankaran

@bloodgenes

5 years

Could gene-centic functional screens be valuable for functional follow up of #GWAS results, in addition to the numerous variant-centric approaches being employed? Our preprint applying this approach for blood trait GWAS is posted: (1/2)

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Vijay Sankaran

@bloodgenes

3 years

Exciting work from @FlavellLab , @Halene_lab , and colleagues from @YaleMed to enable improved human RBCs survival in immunodeficient mice in @ScienceMagazine :

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Vijay Sankaran

@bloodgenes

3 months

Wonderful to be here in Seattle to give the 2024 George Stamatoyannopoulos Lecture at @UW ! Terrific dinner with @ex_vivo , #ThaliaPapayannopoulou , @jeffvierstra , @HPKiem at @larkseattle ! Looking forward to a terrific day tomorrow! 🙏

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Vijay Sankaran

@bloodgenes

4 years

Enjoyed writing an "In Translation" preview with @la_liggett and Richard Voit of this terrific article from @AyalaTovy , @Goodell_Lab , and colleagues in @CellStemCell : Here is our preview - Sowing the Seeds of Clonal Hematopoiesis:

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Vijay Sankaran

@bloodgenes

3 years

WOW!!! I feel so fortunate to be a physician-scientist and see amazing advances like this!

KRASKickers

@KRASKickers

3 years

APPROVED #KRAS first drug HUGE News !! #LumaKRAS 🎯It is Official #sotorasib #KRAS we are #KickingCancersKRAS @FDAOncology @AmgenOncology @OncoAlert

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Vijay Sankaran

@bloodgenes

2 years

Fantastic dinner with @AnnaEnim , @skimomiks , and #MattGreenblatt at @jeangeorges 's JoJo restaurant! Excited to visit and speak at @WeillCornell / @WCMCPathology , as well as @nygenome , tomorrow!🙏 to @AnnaEnim and @notSoJunkDNA for the invitations!

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Vijay Sankaran

@bloodgenes

5 years

Amazing to think that just 10 years ago I was here at ASH presenting the BCL11A shRNA experiment in vitro showing great HbF induction and now David Williams and colleagues from @ChildCancerCare have done this in vivo! #ASH18

Adam Feuerstein ✡️

@adamfeuerstein

5 years

Novel gene therapy ‘switch’ for sickle cell disease shows encouraging results in pilot trial #ASH18

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Vijay Sankaran

@bloodgenes

8 months

Terrific to write this preview in @CellCellPress with Samantha Joubran on an outstanding paper describing the structure of the THPO-MPL complex and its role in hematopoiesis from the Garcia lab:

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Vijay Sankaran

@bloodgenes

3 years

Awesome to see the tremendous progress in translating our observations on the role of BCL11A in hemoglobin switching to therapy for #SickleCell disease! #ASH20 Hopefully we can continue to use human genetics and #V2F efforts to identify more therapies to help our patients!

Adam Feuerstein ✡️

@adamfeuerstein

3 years

Preliminary but ‘nothing short of great.’ New data on CRISPR treatment for blood diseases suggest cure is possible Biggest story of #ASH20 . Free for all to read!

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