Alex Bick @AlexBickMDPhD Twitter profile

Last Seen Profiles

@nippon_no_haruk

@bia_campbelll

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@boling_bulldogs

@GroupeInops

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@TexansPR

@kennedyhebert22

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@ChurchRespecter

@s_a_sargsyan

@stw_pdg

@naragakkai32

@ThePJHL

@tori_whillock

@nobaranail

Alex Bick

@AlexBickMDPhD

3 months

Excited to share @AllofUsResearch program’s flagship genomics paper describing 245,388 clinical-grade genome sequences encompassing >1 billion genetic variants published today in @Nature

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Alex Bick

@AlexBickMDPhD

4 years

Why do >10% of older adults have clonal blood mutations? Simultaneous germline & somatic genome analysis in ~97K pinpoints causal mechanisms. This work w/ @pnatarajanmd , @skathire , @J__Stock now online @nature : Tag-team tweetorial w/ @pnatarajanmd ! 1/n

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Alex Bick

@AlexBickMDPhD

1 year

Out in @Nature today, we describe a new method "PACER" to estimate clonal expansion rate and use it to identify that aberrant TCL1A activation as a cause of #CHIP expansion and potential therapeutic target @J__Stock @Jk_Gopakumar @jaiswalmdphd

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Alex Bick

@AlexBickMDPhD

9 months

Academics outside the US can now apply to access @AllofUsResearch . Please spread the word! cc: @dgmacarthur @ceclindgren @timfrayling @minouye271 @nicolesoranzo @GLettre @samrip @ShaiCarmi @jgustavsmith @andganna @PaulLacaze @drjamesware @nickywhiffin

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Alex Bick

@AlexBickMDPhD

3 years

Out in @NatureMedicine today - @abhinrl demonstrates that distinct #ClonalHematopoiesis mutational profiles are associated with myeloid and lymphoid malignancy. A great collaboration with the @pnatarajanmd and Ebert labs!

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Alex Bick

@AlexBickMDPhD

2 years

Honored to be named a 2022 @pewtrusts Pew-Stewart Scholar for Cancer Research! Grateful for support from @VUMC_Medicine , @VUmedicine , @VUMC_Cancer , @VUMCgenetics and my mentors ( @pnatarajanmd , @skathire ), collaborators ( @jaiswalmdphd ) & trainees

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Alex Bick

@AlexBickMDPhD

1 year

Recurring somatic mutations are uncommon and inconsequential right? Nope! Out today in @ScienceAdvances , our work led by @J__Stock disproves these widely held assumptions, discovering a new class of non-coding somatic mutations in blood with phenotypic impact. 🧵👇

Josh Weinstock

@J__Stock

1 year

Little is known about non-coding somatic mutations in people without cancer. To learn a bit more about this class of mutations, we comprehensively profiled blood somatic mutations across ~43K individuals from the TOPMed consortium, now out @ScienceAdvances

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Alex Bick

@AlexBickMDPhD

2 years

Excited to launch @tensixteenbio today with fellow scientific co-founders @pnatarajanmd , @jaiswalmdphd and Ben Ebert! Backed by @ForesiteLabs @ForesiteCapital @GVteam and led by Mark Chao, we aspire to develop precision medicines to treat #CHIP .

With Forty Seven co-founder at the helm, new biotech spinout launches to target mutations potenti...

Mark Chao is going back into biotech — and his new company, launched this morning, is going after mysterious mutations in the blood and how they impact disease. If the name seems familiar, you might...

endpts.com

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Alex Bick

@AlexBickMDPhD

4 years

Thrilled to share that I received a 2020 @NIHDirector 's Early Independence Award () thanks to the tremendous support of @VUMC_Medicine @VUMCgenetics and @broadinstitute @MGHMedicine mentors @skathire @pnatarajanmd

NIH Common Fund

@NIH_CommonFund

4 years

Guess what? The @NIHDirector ’s awards for #NIHHighRisk research have been announced. Read about innovative #biomedical and behavioral research early career, junior, and seasoned scientists will conduct through these awards:

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Alex Bick

@AlexBickMDPhD

1 year

TET2 mutations: causes #CHIP in hematopoietic stem cells but good for CAR-T therapy? Interesting study in @Nature provides mechanistic depth to 2018 case report () showing how TET2 disruption promotes CAR-T therapeutic efficacy

TET2 guards against unchecked BATF3-induced CAR T cell expansion

Nature - Disruption of TET2 increases the antitumour efficacy of CAR T cells, but establishes an epigenetic state that is prone to hyperproliferation and accumulation of secondary mutations.

www.nature.com

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Alex Bick

@AlexBickMDPhD

6 months

Conceptually flawed paper from deCODE on #CH in @NatureGenet today TLDR: Different clones have distinct disease profiles so lumping distinct forms of CH together is uninformative. #CHIP is associated with CVD in both smokers and non-smokers in full UKB 🧵

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Alex Bick

@AlexBickMDPhD

4 years

Excited to join the @vumchealth faculty with exceptional support for my physician-scientist career from @BWFUND #bwfcams

Bick receives Burroughs Wellcome Fund Career Award for Medical Scientists - VUMC News

Alexander Bick, MD, PhD, assistant professor of Medicine in the Division of Genetic Medicine at Vanderbilt University Medical Center, is a recipient of the 2020 Burroughs Wellcome Fund (BWF) Career...

news.vumc.org

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Alex Bick

@AlexBickMDPhD

2 years

Today’s FDA approval of @bmsnews #mavacamten for patients with hypertrophic cardiomyopathy is the culmination of a remarkable bench to bedside translational success story with important #PrecisionMedicine implications. 1/7

FDA approves Bristol Myers' oral heart disease drug

Bristol Myers Squibb said on Thursday the U.S. Food and Drug Administration (FDA) approved its oral heart disease drug Mavacamten, making it the first cardiac myosin inhibitor to be permitted for use...

www.reuters.com

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Alex Bick

@AlexBickMDPhD

2 years

Somatic Mutations in Cardiovascular Disease with @VUMC_heart @VUMC_MedPSTP fellow @brettheimlich now out in @CircRes . Spoiler alert: there is more to genetic mosaicism in CVD than #CHIP !

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Alex Bick

@AlexBickMDPhD

2 years

Published #CHIP datasets are growing exponentially! In a new preprint, we share how to reliably identify CHIP in ~550k @AllofUs genomes & @UKBiobank exomes. We find small parameters make a BIG difference in CHIP quality & disease associations.

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Alex Bick

@AlexBickMDPhD

1 year

Clonal hematopoiesis of indeterminate potential no longer ... out in @NEJMEvidence today @Lachelle_Dawn presents a clinically useful risk score to prognosticate risk of malignant transformation & death in patients with #CHIP & #CCUS

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Alex Bick

@AlexBickMDPhD

6 months

Out today in @NatureGenet , just in time for #ASHG23 our work led by @Sasha_Jakubek , @pascheet and #PaulAuer identified causes & consequences of chromosomal scale mosaic alterations in diverse individuals in @nih_nhlbi #TOPMed

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Alex Bick

@AlexBickMDPhD

3 years

Honored to receive a @RUNX1Research & @EdwardPEvansFdn 🔥 grant this year supporting our effort to use genetics & biobanks to identify specific anti-inflammatory therapies to modulate #CH growth. @VUMCgenetics @VUMC_Cancer @VUMC_Medicine

The RUNX1 Research Program

@RUNX1Research

3 years

RRP and The Edward P. Evans Foundation are thrilled to announce that Dr. Anupriya Agarwal of @OHSUKnight and @AlexBickMDPhD of @VUMC_MD are recipients of 2021 RRP-EVANSMDS Focused Impact REsearch (FIRE) Grants. Read more about their fascinating research:

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Alex Bick

@AlexBickMDPhD

2 years

First day of first grade! @JGHornets @MetroSchools

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Alex Bick

@AlexBickMDPhD

4 years

I’m excited to bring #PrecisionMedicine directly to our @VUMC_Medicine patients with this morning's launch of the Preventative Genomics service at the @VUMChealth Genomics and Therapeutics Clinic! #MakingHealthCarePersonal @VUMC_Insights

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Alex Bick

@AlexBickMDPhD

2 years

I am so excited for @AllofUsResearch to release their first Genomic dataset today including more than 150,000 whole genomes and arrays from diverse participants, freely available to researchers at

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Alex Bick

@AlexBickMDPhD

9 months

Many thanks also to the NIA for delivering the NOGA for our lab's third R01! We are excited to advance the field's understanding of lymphoid clonal hematopoiesis.

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Alex Bick

@AlexBickMDPhD

3 years

Excited to share our review of CH genetics in @NatureRevGenet today! To date, genetic analyses consider only a single kind of CH. Looking forward to working with @AlexSilverMSTP , @pnatarajanmd , @bloodgenes , @freeseek82 , @jaiswalmdphd , @zekavatm , @J__Stock to fill in this gap!

Alex Silver

@AlexSilverMSTP

3 years

In our @NatureRevGenet review "Germline Risk of #ClonalHematopoiesis ", we examine how inherited variation shapes the landscape of acquired mutations in the blood. One key takeaway: different types of somatic #CH mutations have overlapping germline risk.

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Alex Bick

@AlexBickMDPhD

4 years

Enrolled our first research participant in the @VUMC_Cancer / @VUMC_heart clonal hematopoiesis registry & biorepository today! One down, 10k+ to go. #smallvictories Many thanks to @ShannonSomerMD , @FerrellLabVUMC , @CardioOncology , @AlexSilverMSTP and @VUMC_Medicine team!

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Alex Bick

@AlexBickMDPhD

2 months

Delighted to share that @VUMCgenetics PhD student @taralynn_mack was awarded a @VU_Provost Pathbreaking Discovery Award, recognizing Tara's research excellence and contributions to our @VanderbiltU community!

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Alex Bick

@AlexBickMDPhD

1 year

Out in @CircAHA today, we use high quality #CHIP calls to show that IL6 receptor signaling modulates association between CHIP and CVD in 'full' UK Biobank dataset.

Interleukin-6 Receptor Polymorphism Attenuates Clonal Hematopoiesis-Mediated Coronary Artery...

www.ahajournals.org

Caitlyn Vlasschaert

@DrFlashHeart

1 year

Last week, I shared how we derived CHIP calls in the UK Biobank (N ~450k). In a study out today in Circulation ( @CircAHA ), we use these CHIP calls to contribute to an ongoing debate regarding IL-6 signaling mediating the association between CHIP & CAD.

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Alex Bick

@AlexBickMDPhD

3 years

Excited for our first day of kindergarten @MetroSchools @JGHornets !

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Alex Bick

@AlexBickMDPhD

2 years

New UK Biobank 50k Olink + exome analysis by @RyanDhindsa @ben_b_sun @euanashley @SlavePetrovski & colleagues. Identify rare variants with large effects on circulating protein abundance missed by GWAS and #CHIP gene specific proteomic signatures.

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Alex Bick

@AlexBickMDPhD

8 months

Cloud computing is transforming genomics. But what happens when cohorts live in different clouds? Work in @NatureComms with N. Deflaux @verily , @MargaretSunitha & @pnatarajanmd identify scientific & technical implications of our multi-cloud future. @AllofUsResearch @uk_biobank

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Alex Bick

@AlexBickMDPhD

6 months

In a new preprint led by @taralynn_mack , we share the secret behind our $8 #CHIP assay that has been used by several dozen investigators to run >100,000 samples at our @VUMCDiscoveries VANTAGE core. Please get in touch if this would accelerate your research.

Tara Mack

@taralynn_mack

6 months

Interested in a cost-effective & scalable method to identify CHIP mutations at high coverage? Check out our preprint! 1/10 🧵 @AlexBickMDPhD @DrFlashHeart @AlexSilverMSTP @brettheimlich @HannahPoisner @VUMCgenetics

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Alex Bick

@AlexBickMDPhD

3 years

New paper from Seishi Ogawa @riken_en looking across Clonal Hematopoiesis mutational spectrum in @NatureMedicine . Co-occurrence of SNPs/CNVs is non-random. Having both kinds of mutations increases risk of blood cancer & CVD mortality.

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Alex Bick

@AlexBickMDPhD

4 months

UBA1 somatic mutations of indeterminate potential? our provocative finding in @AllofUsResearch led by @rheumrob with @jamesfbrogan , @kwbyram & @petercgrayson @VUMC_MedPSTP , @VUMCRheum @NIH_NIAMS

ACR_Journals

@ACR_Journals

4 months

Somatic mutations in UBA1 cause VEXAS, a severe inflammatory syndrome. For the first time, researchers have found 74 people with the mutation who don't have VEXAS. Studying them may give a peek into the earliest phases of disease. In A&R @rheumrob

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Alex Bick

@AlexBickMDPhD

2 years

@AllofUsResearch released an incredible genomics resource today. Can we leverage cloud computing to integrate with datasets like @uk_biobank ? Some early observations from work w/ @MargaretSunitha , Nicole Defaux @verilylifesci , @pnatarajanmd

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Alex Bick

@AlexBickMDPhD

1 year

Will have @OpenAI chatbot write my next NIH project narrative statement

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Alex Bick

@AlexBickMDPhD

4 months

We find that exposure to air pollution modifies the association between #CHIP & lung cancer in @uk_biobank in a gene x environment interaction. @DrFlashHeart @MattLanktree @MelindaAldrich @QMyPath @marcobuttigieg_ @yash_pershad @VUMCDiscoveries @VUMCgenetics @VUMCHemOnc

Caitlyn Vlasschaert

@DrFlashHeart

4 months

Air pollution is a recently recognized driver of lung cancer among never-smokers. In a new preprint, we show that clonal hematopoiesis of indeterminate potential (CHIP) and PM2.5 form a novel gene × environment interaction promoting NSCLC tumorigenesis.

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Alex Bick

@AlexBickMDPhD

1 year

~20% of @VUMChealth cath lab patients have #CHIP . Patients with TET2 mutations had worse left main coronary disease. Important work by @brettheimlich and @MichaelR21 that will accelerate CVD precision medicine trials. @VUMCgenetics @VUMC_heart @VUMC_Medicine

Brett Heimlich

@brettheimlich

1 year

Ever wondered where to find patients for a CHIP/cardiovascular disease clinical trial? How about in the cardiac cath lab. 🧵

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Alex Bick

@AlexBickMDPhD

1 year

Reliably identifying #CHIP mutations that predispose to blood cancer & aging diseases is hard. In @BloodJournal today, @DrFlashHeart shares our secret sauce: leveraging large scale data. cc: @VUMCgenetics @VUMC_Medicine @VUMC_Cancer @AllofUsResearch 🧵👇

Caitlyn Vlasschaert

@DrFlashHeart

1 year

Our paper demonstrating an approach to CHIP curation in large datasets is now out in Blood ( @BloodJournal )! 🩸 We identify CHIP in >500,000 individuals and show how common challenges such as sequencing artifacts and germline variants can be addressed.

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Alex Bick

@AlexBickMDPhD

4 months

No better way to start 2024 than in Hawaiʻi with the lab at the Pacific Symposium on Biocomputing #PSB24 .

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Alex Bick

@AlexBickMDPhD

3 years

Could not be more excited by today's FDA advisory panel vote to recommend the Pfizer/BioNTech COVID-19 vaccine for 5-11 yr olds! Our 5 yr old will be first in line when its available @VUMChealth -- hopefully next week.

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Alex Bick

@AlexBickMDPhD

3 years

Looking forward to @NIH NIA’s Virtual Workshop on Clonal Hematopoiesis! Lineup tomorrow includes @UVACVRC Ken Walsh keynote & sessions on CH and aging ( @jaiswalmdphd @pnatarajanmd @Goodell_Lab ) and CH detection ( @freeseek82 @DruleyLab @OliverVenn )

Virtual Workshop: Measures of Somatic Mutation-related Clonal Hematopoiesis in Humans: Enhancing...

NIA hosted a virtual workshop on clonal expansion of hematopoietic cells associated with somatic mutations as a function of age in humans.

www.nia.nih.gov

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Alex Bick

@AlexBickMDPhD

1 year

Congratulations @DrFlashHeart on an outstanding thesis defense this morning! We couldn't make it to @QueensuDOM , so we held a virtual watch party @VUMCgenetics . @MattLanktree @QMyPath @tmedQueens

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Alex Bick

@AlexBickMDPhD

6 months

Congratulations to @KimrynRathmell on her nomination as @theNCI director! I am grateful for your mentorship and leadership at @VUMC_Medicine . Biden picks Vanderbilt physician to lead National Cancer Institute

Biden picks Vanderbilt physician to lead National Cancer Institute

W. Kimryn Rathmell, a prominent cancer researcher, will oversee initiatives intended to reduce the cancer death rate and speed up clinical breakthroughs.

www.washingtonpost.com

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Alex Bick

@AlexBickMDPhD

2 years

Congratulations to @vangalenlab , @bloodgenes @CalebLareau and team on the publication of MAESTER! An exciting tool for integrating somatic genotype and RNA phenotype in mosaic states ... in clonal hematopoiesis and beyond.

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Alex Bick

@AlexBickMDPhD

2 years

We had a great time #CHIP -ing off against @VUMC_Medicine & @VUMCHemOnc friends in the @FerrellLabVUMC and Savona lab @Topgolf this afternoon. What the Bick lab lacked in skill, we made up for with our coordinated golfing attire.

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Alex Bick

@AlexBickMDPhD

3 years

New #CHIP observation - DNMT3A decreases bone mass via increased osteoclastogenesis. Effect is ameliorated by alendronate or anti-IL-20. A neat observation from @petergkim ! @DamonRunyon , @EdwardPEvansFdn

JExpMed

@JExpMed

3 years

Somatic mutations such as in DNMT3A accumulate in hematopoietic stem cells in clonal hematopoiesis of indeterminate potential (CHIP). Kim, Ebert et al @DanaFarber show that CHIP promotes #osteoporosis via bone-resorbing #osteoclasts . #Hematopoiesis

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Alex Bick

@AlexBickMDPhD

6 months

#ACR23 check out @rheumrob 's late breaking poster tomorrow - he has identified individuals with somatic UBA1 mutations who are resilient to VEXAS Full details in his preprint: @ACRheum @VUMCRheum @VUMC_MedPSTP

Analysis of 245,368 diverse individuals from the NIH All of Us Cohort identifies incomplete...

Objective Somatic mutations in UBA1 cause the recently described systemic auto-inflammatory syndrome, VEXAS. Study of this disease has largely been limited to highly symptomatic patients. We sought...

www.medrxiv.org

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Alex Bick

@AlexBickMDPhD

18 days

Congratulations Dr. @AlexSilverMSTP on an outstanding thesis defense! Collaborating with Alex has been a highlight of my early faculty career. I am excited to see where his physician-scientist journey takes him next! @VanderbiltMSTP @VUMCHemOnc @VUMC_Cancer @VUmedicine

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Alex Bick

@AlexBickMDPhD

2 months

Excited to share this paper in @BloodAdvances led by @brettheimlich , @PBdoingscience & @alyssa_c_parker with @FerrellLabVUMC that uses mitochondrial lineage tracing techniques pioneered by @vangalenlab @CalebLareau , @bloodgenes to identify transcriptional consequences of #CHIP

Brett Heimlich

@brettheimlich

2 months

Ever wondered how the two most common CHIP mutations affect gene expression in human PBMCs? Our recently published paper addresses this question using mitochondrial DNA lineage tracing.

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Alex Bick

@AlexBickMDPhD

3 years

We like REGENIE so much that we built a WDL to make it easy for anyone to run it on @nih_nhlbi #BioDataCatalyst , @TerraBioApp or @useAnVIL : & We ran a ~90,000 person GWAS on two traits in <6 hrs for ~$25 cc: @VdaGeraldine

GitHub - briansha/Regenie_WDL: WDL for Regenie

WDL for Regenie. Contribute to briansha/Regenie_WDL development by creating an account on GitHub.

github.com

Jonathan Marchini

@marchini

3 years

Introducing REGENIE v2 that adds new features to support gene burden analysis of exome datasets eg. @ukbiobank exome data. This is amazing work from @joellembatchou and @covariani

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Alex Bick

@AlexBickMDPhD

2 years

In new preprint, @doctorveera & @RegeneronDNA team report that top 2 exome associations for smoking are somatic mutations in ASXL1 & DNMT3A... highlighting that #CHIP can contaminate germline call sets. Replicates work by us & others identifying smoking as a CHIP risk factor

Veera Rajagopal 

@doctorveera

2 years

Excited to share our new preprint in which we report an exome-wide association study of smoking behavior in up-to ~750,000 individuals which discovered a beautiful drug target. Please take a seat. It's storytelling time. 🧵

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Alex Bick

@AlexBickMDPhD

2 years

We recently tested @CEGX_news "5-letter" sequencing in a DNMT3A R882H CHIP patient sample. Resolving methylation at the read level is a remarkable tool for decoding somatic mosaicism. More to come ... ... and check out their newly posted preprint:

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Alex Bick

@AlexBickMDPhD

2 years

New preprint from @siddhartha_kar @stevesphd @VassiliouLab and colleagues - GWAS and phenotypic associations of #CHIP in 200k UK Biobank participants . Excellent use of mendelian randomization to separate CHIP cause from effect.

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Alex Bick

@AlexBickMDPhD

6 months

Happy Halloween!

Tara Mack

@taralynn_mack

6 months

No tricks just peaks in the Bick Lab! Happy Halloween! @VUMCgenetics

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Alex Bick

@AlexBickMDPhD

1 year

A provocative observation by @ahoischen , Lena Carlsson, et al that #CHIP clone size increased with age in obese individuals, but not in those who underwent bariatric surgery. Perhaps CHIP patients would benefit from tirzepatide or semaglutide?

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Alex Bick

@AlexBickMDPhD

2 years

Is loss of y chromosome a cause or consequence of aging disease? Out in @ScienceMagazine today Ken Walsh and Saicho Sano @CardioUva recapitulates cardiac fibrosis in a LoY mouse model and reverses it with TGF-B inhibition.

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Alex Bick

@AlexBickMDPhD

10 months

An exciting day for @VUMChealth scientists! 250,000 BioVU participants will be whole genome sequenced in the next two years. @VUMCgenetics @VUMC_Medicine

Insights @ VUMC

@VUMC_Insights

10 months

NEW— . @illumina and @VUMChealth 's @NashvilleBio welcome the five founding members of the Alliance for Genomic Discovery to speed development of therapeutics through large-scale #genomics to ensure equitable access to precision health treatment. #biopharma

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Alex Bick

@AlexBickMDPhD

11 months

What can we learn from >350 billion genetic variant-trait associations across diverse individuals? Proud play a small role in this monumental @VAResearch effort 4+ years in the making led by @_anuragverma @JennyGenetics @madduri , @damrauer & @kat_liao

Diversity and Scale: Genetic Architecture of 2,068 Traits in the VA Million Veteran Program

Genome-wide association studies (GWAS) have underrepresented individuals from non-European populations, impeding progress in characterizing the genetic architecture and consequences of health and...

www.medrxiv.org

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Alex Bick

@AlexBickMDPhD

2 years

Grateful for @NIHDirector 's Early Independence Award enabling me to cut 5+ years from my time to first R01. Recent eval found EIA PIs had similar future funding & equally cited papers as ESIs. Perhaps #NIH should fund more physician-scientists to skip the K-08? #NIHHighRisk

George Alba

@galbamd

2 years

That’s quite a lot of 44-year-old newly minted Assistant Professors

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Alex Bick

@AlexBickMDPhD

2 months

Grateful for @pewtrusts for bringing our community together for an incredible week of science at the 2024 @pewhealth biomedical scholars meeting in Tucson! @Neal_Lab @jkimmey @Mari_Byndloss @kelliejurado @stergachislab @Anders_S_Hansen

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Alex Bick

@AlexBickMDPhD

3 years

>10% of older adults have CHIP but only a fraction develop heart disease. New paper led by @DanielNachun & @jaiswalmdphd shows that epigenetic aging clocks can stratify CVD risk in patients with CHIP leveraging @nih_nhlbi TOPMed

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Alex Bick

@AlexBickMDPhD

3 years

Chasing @TerraBioApp WDLs and waterfalls at the first annual Bick Lab retreat @evinsmill ! @VUMCgenetics

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Alex Bick

@AlexBickMDPhD

2 years

So proud of @taralynn_mack who did an outstanding job on her qualifying exam! Many thanks to her @VUMCgenetics exam committee @MelindaAldrich @FerrellLabVUMC @JaneFFerguson @JDMosley_Moses .

Tara Mack

@taralynn_mack

2 years

Excited to say that I passed my qualifying exam today and am officially a PhD Candidate!! Couldn’t have done it without the support of @AlexBickMDPhD and my amazing labs! 🎉🧬

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Alex Bick

@AlexBickMDPhD

11 days

Grateful for the support from @AFARorg and @hevolution_f for our work!

AFAR

@AFARorg

12 days

Through a @Hevolution_f and AFAR grant, @AlexBickMDPhD , of @VUMCDiscoveries will research "Identifying Clonal Hematopoiesis Resiliency Mechanisms." Learn more here: #stemcells #DNA #Clinical #humangenome #Longevity

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Alex Bick

@AlexBickMDPhD

2 years

Congratulations @katrinarmstrong on your exciting new role! I will always be grateful for your advice to skip cardiology fellowship and just start my lab ...

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Alex Bick

@AlexBickMDPhD

8 months

Very Proud of @brettheimlich ! Looks like an impressive group of young investigators at #NCYIF23 this year! @VUMCDiscoveries @VUMC_MedPSTP @VUMC_heart @KimrynRathmell @JaneFreedmanMD @NCYIForum

NCYIF

@NCYIForum

8 months

Dr. J. Brett Heimlich, MD, PhD of @VUMCHealth presents Macrophage Migration Inhibitory Factor (MIF) Mediates TET2 CHIP Pathology. #MedTwitter #MedX #MedEd #NCYIF23

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Alex Bick

@AlexBickMDPhD

6 months

Stop by @taralynn_mack 's #ASHG23 CHIP clonal expansion rate poster (PB1424) at 3pm today @yash_pershad is presenting on #mCA fitness tomorrow (PB1743) @alyssa_c_parker is happy to take questions about #CHIP & single cell sequencing (stay tuned for @cziscience single cell mtg)

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Alex Bick

@AlexBickMDPhD

2 months

FY24 NIH federal spending bill includes 100M increase in funding to NCI and NIA over FY23. Other institutes largely flat budget. See pgs 495-503:

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Alex Bick

@AlexBickMDPhD

4 days

I highly recommend #EarlyCareer researchers consider applying for @NIH_CommonFund Early Independence (DP5) & New Innovator (DP2), @NIGMS MIRA (R35), @NIDAnews Avenir (DP-1), @NIH Katz R01 and others which can shave a decade or more off of the "time to R01." @A_P_S_A @the_asci

Extramural Research

@NIHgrants

4 days

New from the Open Mike blog: Age of Principal Investigators at the Time of First R01 Remains Level with Recent Years in FY 2023 🥼

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Alex Bick

@AlexBickMDPhD

2 years

... and for other #EarlyCareer #PhysicianScientist out there ... the key take away is that we should prioritize discovering a new genetic disease mechanism early in our careers ... since it will still take 30 years to reach patients 😉

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Alex Bick

@AlexBickMDPhD

2 years

With somatic driver mutations arising early in life, a therapeutic strategy to prevent blood cancer may require targeting clonal expansion rate. Wonderful work from @jyoti_nangalia and team!

Jyoti Nangalia

@jyoti_nangalia

2 years

Delighted to share my research group's latest study, published today @Nature 👉 where we trace the life histories of blood cancer development in patients @sangerinstitute @SCICambridge @Cambridge_Uni

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Alex Bick

@AlexBickMDPhD

2 years

Great technology feature by @j_perkel in @Nature today highlighting how @TerraBioApp can be leveraged to perform collaborative genomics analyses at scale

Terra takes the pain out of ‘omics’ computing in the cloud

Nature - The web-based tool allows scalable, user-friendly computation across multiple data sets

www.nature.com

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Alex Bick

@AlexBickMDPhD

1 year

In 2016 @pnatarajanmd @nbgmd @HeidiRehm @skathire @RobertCGreen & I argued it was important to give research participants the option to learn if they have an actionable DNA mutation Today #AllofUs launched the return of DNA results to participants!

AllofUsResearch

@AllofUsResearch

1 year

@AllofUsResearch has begun returning personalized health-related DNA results to participants! Participants can choose to get information about their hereditary disease risk or how their bodies respond to certain medicines. Learn more:

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Alex Bick

@AlexBickMDPhD

6 months

Fun times at #ASHG23 catching up with friends from near and far! @pascheet @Sasha_Jakubek @ZhiYu_ACGT @JackieHellwege @Megan_M_Shuey @RyanDhindsa

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Alex Bick

@AlexBickMDPhD

4 months

Delighted to speak with @patrick_j_short on this episode of the Genetics Podcast and share some of our exciting research and clinical work @VUMChealth @VUMCDiscoveries @VUMC_Medicine @VUMCgenetics

Sano Genetics

@sanogenetics

4 months

Episode 116 of The Genetics Podcast is live! 🚀 In this episode, @AlexBickMDPhD , Assistant Professor of Medicine in the Division of Genetic Medicine at @VanderbiltU , talks clonal hematopoiesis, kidney disease breakthroughs & more. Tune in here👇

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Alex Bick

@AlexBickMDPhD

3 years

New evidence that @NIH Vietnam-era 'Yellow Beret' program accelerated physician-scientist careers, rather than reflecting selection bias, by using a clever control group -- the 'runner-up' applicants. @A_P_S_A @the_asci via @wired

What Medical Researcher Training Can Learn From the 'Yellow Berets'

A new study shows how the Vietnam War–era initiative shaped a generation of star physician-researchers—and offers lessons that can be applied today.

www.wired.com

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Alex Bick

@AlexBickMDPhD

4 years

Thrilled that @genome_gov #Genomics2020 Strategic Vision in @Nature this week cites clonal hematopoiesis & somatic mosaicism as a key insight for the next decade. Come join our team @VUMCgenetics and make this vision a reality.

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Alex Bick

@AlexBickMDPhD

2 years

Excited for @UCLAHealth IM resident @MichaelR21 to share our work on the association of #CHIP with incident severe aortic stenosis at #AHA21 cc: @AHAMeetings , @CardioOncology , @AHAScience @uclaimchiefs

Michael Raddatz

@MichaelR21

3 years

With all the content from #AHA21 about to start, add our moderated session (HF.MDP.16) to your agenda! All levels of basic to clinical data on HF and valve disease. Great session including work from @vbluml @EstiCastillero @lab_ferrari @SammourMD , moderated by @rcstarling .

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Alex Bick

@AlexBickMDPhD

2 years

Looking forward to sharing the latest @AllofUsResearch genomics resources at #ASHG22 . We will also have a @GeneticsSociety workshop to help folks get started on the #ResearchAllofUs platform.

Josh Denny

@AllofUsCEO

2 years

It’s exciting to see so much research using the @AllofUsResearch Program’s dataset being presented at the annual @ASHG conference later this month! These are just a few, but we’ll have a full list at our booth in the exhibit hall. Stop by! #ResearchAllofUs

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Alex Bick

@AlexBickMDPhD

2 years

Another fantastic lab retreat @evinsmill in the books! @VUMC_Medicine @VUMCgenetics

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Alex Bick

@AlexBickMDPhD

4 years

Looking forward to trying out @weizhouw @XihongLin @dalygene latest iteration of SAIGE - that enables censored time-to-event GWAS analysis. I predict that this will become the new standard for GWAS of EHR-derived phenotypes.

GitHub - weizhou0/GATE

Contribute to weizhou0/GATE development by creating an account on GitHub.

github.com

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Alex Bick

@AlexBickMDPhD

3 months

Congratulations to @TothovaLab , @TheDoctorIsVin , @bowman_rl , @lindemilesphd & all of this year's other @ASH_hematology ASH Scholar awardees! Very well deserved! #ASHAwards

ASH

@ASH_hematology

3 months

ASH proudly announces the 36 recipients of our 2024 ASH Scholar Awards, one of our most prestigious research award programs for fellows & junior faculty dedicating a #career to #hematology research! #ASHAwards Read about our awardees today:

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Alex Bick

@AlexBickMDPhD

1 year

In new preprint, we show how a small number of mutated #CHIP cells can cause CVD through driver gene specific mechanisms. The secret sauce: identifying which cells have #CHIP mutation by combining mitochondrial lineage tracing with single cell DNA sequencing🧵👇

Brett Heimlich

@brettheimlich

1 year

Hey #CHIP folks, ever wondered how clonal cells in the periphery differ from their wildtype counterparts? check out👉 @AlexBickMDPhD @FerrellLabVUMC @alyssa_c_parker @PBdoingscience

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Alex Bick

@AlexBickMDPhD

1 year

Congratulations to Bick lab *high school* 🌟 @Emma__Bunch - named a @Society4Science #RegeneronSTS Top 300 Scholar today! Emma studied #CHIP & breast cancer in @AllofUsResearch mentored by @VanderbiltMSTP @sarah_c_reed @VUMC_Cancer @VUMC_Medicine @VUMCgenetics @VUmedicine

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Alex Bick

@AlexBickMDPhD

2 years

Fall vibes @Cheekwood 🎃

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Alex Bick

@AlexBickMDPhD

1 year

Engaging high school students in authentic research experiences is a great way to build the #STEM pipeline. Thank you @CarolineCencer for sharing @Emma__Bunch 's story! #SciComm @VUmedicine @VUMCDiscoveries @VUMC_Medicine @VUMC_Cancer @Society4Science

These high school seniors found mentors in Vanderbilt research labs — and were honored in a...

The students were given the opportunity to work on original research projects at Vanderbilt, diving straight into learning various laboratory techniques and how to formulate a scientific narrative

voice.vumc.org

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Alex Bick

@AlexBickMDPhD

2 years

So glad @VanderbiltMSTP alum @MichaelR21 was able to break away from @DOM_UCLA rounds to join us @BavelDTLA for #ASHG22 lab dinner. Looking forward to sharing the exciting work he & @taralynn_mack have done together soon! @uclaimchiefs @VUMCgenetics

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Alex Bick

@AlexBickMDPhD

2 years

A remarkable bedside -> bench -> bedside story @JRosenbergMDPhD solved as a @MGHMedicine @mghmedres resident. Pairing clinical curiosity with rigorous scientific inquiry yielded a N-of-1 precision medicine treatment.

Jake Rosenberg

@JRosenbergMDPhD

2 years

Excited to share our study of a patient with aplastic anemia, where a genetic diagnosis led to a successful targeted intervention, and new avenues of promising biology @MedCellPress . 🧵1/

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Alex Bick

@AlexBickMDPhD

5 months

Congratulations to newly minted PhD Candidate @HannahPoisner on passing her qualifying exam! Hannah's celebration featured the ALL of Us trivia game (no relation to @AllofUsResearch )

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Alex Bick

@AlexBickMDPhD

1 year

Congratulations to @DrFlashHeart for being selected as a 2023 @the_asci Emerging Generation Awardee! Caitlyn is a leader in #CHIP and kidney genetics. We are lucky to have her as part of our extended research group!

Home - The American Society for Clinical Investigation

This is the home page for The American Society for Clinical Investigation website.

the-asci.org

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Alex Bick

@AlexBickMDPhD

4 months

Congratulations @AshKishtagari and team! Individuals with "homozygous" CHIP mutations (2 copies) have increased risk of transforming to blood cancer.

Ashwin Kishtagari, MD

@AshKishtagari

4 months

🙌Happy to share the first publication of 2024 from #BickLab , exploring the role of CHIP mutation zygosity in predicting clonal hematopoiesis transformation risk to hematologic malignancies published now in @BloodCancerJnl @AlexBickMDPhD

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Alex Bick

@AlexBickMDPhD

2 years

I enjoyed sharing the @AllofUsResearch researcher workbench with 200 colleagues this morning. For more on All of Us, come to our platform session "All of Us for All of You" tomorrow 10/27 at 1:45pm - moderated by @kstsosie and @SGoleva

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Alex Bick

@AlexBickMDPhD

1 year

So excited to partner with the RUNX1-FPD patient community in collaboration with @LabObeng , @LabAgarwal , @RUNX1Research & @cziscience to advance our understanding of #inflammation and #CHIP in RUNX1-FPD!

Insights @ VUMC

@VUMC_Insights

1 year

Scientists + clinicians + patients team up to study #inflammation at the single-cell level in the inherited disease RUNX1-FPD, with support from @cziscience . -- cc/ @AlexBickMDPhD @RUNX1Research @LabObeng @LabAgarwal

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Alex Bick

@AlexBickMDPhD

2 years

Working at @VUMC_Medicine & @VUMCgenetics is always a party! Thanks to the Bick and Ferrell labs for celebrating today. @bakedon8th cakes can't be beat😀

Ashwin Kishtagari, MD

@AshKishtagari

2 years

Happy birthday @FerrellLabVUMC @AlexBickMDPhD @alyssa_c_parker !!!

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Alex Bick

@AlexBickMDPhD

7 months

Most studies of clonal hematopoiesis change over time focus on #CHIP . Here @yash_pershad & @taralynn_mack seek to understand why mCAs with the same genetic alteration grow at different rates and find that faster growing mCAs have greater health consequences.

Yash Pershad

@yash_pershad

7 months

Our preprint “Determinants of mosaic chromosomal alteration fitness” is out! @AlexBickMDPhD , @taralynn_mack , and I studied clonal expansion rate of mosaic chromosomal alterations (mCAs) in the @nih_nhlbi TOPMed cohort. 1/7

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Alex Bick

@AlexBickMDPhD

2 years

Deep mutational scanning across DNMT3A - would be a great annotation to integrate into #CHIP mutation calling pipelines. Now we just need TET2 and 2/3 of CHIP would be covered ...

Nicholas Lue

@nicklue8

2 years

Super excited to announce that we’ve just submitted the latest @liaulab ~manuscript~! Tldr: we used base editors + a methylation reporter to do a mutational scan of DNMT3A, a key cancer gene. Highlights below, but check out our preprint at @biorxiv !

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Alex Bick

@AlexBickMDPhD

3 years

A great summary from @nih_nhlbi of our recent work led by @RomitB_MD and @pnatarajanmd on association between heart healthy eating and clonal hematopoiesis

NIH NHLBI

@nih_nhlbi

3 years

Clonal hematopoiesis of indeterminate potential (CHIP) results from changes in cells and affects up to 1 in 10 people over age 70. A study in @JAMACardio finds a potential link between heart-healthful eating patterns and fewer #CHIP incidents.

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Alex Bick

@AlexBickMDPhD

11 months

The lab was working on our volleyball skills @SandbarNash today in preparation for @GordonConf in Human Genetics & Genomics. Looking forward to seeing many colleagues there in two weeks!

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Alex Bick

@AlexBickMDPhD

2 years

Interesting take on constraint from @dimvitsios @RyanDhindsa @SlavePetrovski : Somatic mutations detected in population-scale sequencing help identify blood cancer driver mutations. I am always amazed how many somatic mutations are in 'germline' datasets

Cancer-driving mutations are enriched in genic regions intolerant to germline variation

Analysis of ~125,000 human exomes reveals that cancer-causing mutations accrue in regions where inherited mutations are depleted.

www.science.org

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Alex Bick

@AlexBickMDPhD

1 year

In another extraordinary effort led by @DrFlashHeart with @VUMCKidney 's Ray Harris & @CassyRCohen , we establish #CHIP as a genetic mechanism for acute kidney injury through CHIP-derived renal macrophages. @VUMCgenetics @VUMCDiscoveries

Caitlyn Vlasschaert

@DrFlashHeart

1 year

Sharing a preprint of our latest work: "Clonal Hematopoiesis of Indeterminate Potential is Associated with Acute Kidney Injury" where we study four prospective cohorts and conduct mouse model experiments to identify a new link between CHIP and AKI.

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Alex Bick

@AlexBickMDPhD

8 months

Delighted to kick off #AGBTPH 2023 chaired by @TalkowskiLab , @WendyKChung & @NHGRI_Director with an @AllofUsResearch workshop. @ksamocha & @HeidiRehm gave a great gnomAD workshop. cc: @AllofUsCEO @VUMCgenetics

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