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Journal of Clinical Investigation Profile
Journal of Clinical Investigation

@jclinicalinvest

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The JCI is a premiere venue for discoveries in basic & clinical biomedical science. Est. 1924- Bluesky:

Ann Arbor, MI
Joined December 2010
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@jclinicalinvest
Journal of Clinical Investigation
21 hours
#Cover : Compromised hypothermic cardioprotection in aged donor heart: #Transplantation
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@jclinicalinvest
Journal of Clinical Investigation
3 years
Pharmacological treatment of hyperglycemia in type 2 diabetes: #Review by Simeon I. Taylor et al. @UMmedschool in the #ReviewSeries : 100th Anniversary of Insulin's Discovery ()
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@jclinicalinvest
Journal of Clinical Investigation
3 years
Normal and defective pathways in biogenesis and maintenance of the insulin storage pool: #Review by Ming Liu et al. @peterarvan @umichmedicine in the #ReviewSeries : 100th Anniversary of Insulin's Discovery ()
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@jclinicalinvest
Journal of Clinical Investigation
4 years
The convalescent sera option for containing COVID-19 @ACasadevall1 and Liise-Anne Pirofski discuss a strategy for preventing and treating COVID-19 disease using sera from recovered patients.
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@jclinicalinvest
Journal of Clinical Investigation
3 years
Gastrointestinal motility disorders in neurologic disease: #Review by Michael Camilleri @MayoClinicGIHep in the #ReviewSeries : 100th Anniversary of Insulin's Discovery ()
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@jclinicalinvest
Journal of Clinical Investigation
3 years
Insulin signaling in health and disease: #Review by @LabSaltiel @UCSDMedSchool in the #ReviewSeries : 100th Anniversary of Insulin's Discovery ()
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@jclinicalinvest
Journal of Clinical Investigation
3 years
. @tonipollin @UMmedschool : Monogenic diabetes: a gateway to precision medicine in #diabetes : #Review by Haichen Zhang et al. in the #ReviewSeries : 100th Anniversary of Insulin's Discovery ()
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@jclinicalinvest
Journal of Clinical Investigation
3 years
In honor of the 100th anniversary of the discovery insulin, the JCI has collected a series of review articles, interviews with prominent scientists, and classic JCI papers reporting seminal findings in diabetes, insulin signaling, and insulin resistance:
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@jclinicalinvest
Journal of Clinical Investigation
5 years
Monoclonal antibody targets pathogenic IFN source in cutaneous lupus lesions @biogen @ZuckerSoM #autoimmune #clinicalmedicine
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@jclinicalinvest
Journal of Clinical Investigation
6 months
Conversations with Giants in Medicine: Peter Hotez: JCI’s editor-at-large @UshmaNeill spoke with @PeterHotez about his motivation to become a physician-scientist and his interest in tropical diseases.
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@jclinicalinvest
Journal of Clinical Investigation
4 years
JUST PUBLISHED: Clinical and immunologic features in severe and moderate Coronavirus Disease 2019 Also: Savannah Pederson and Ya-Chi Ho comment on Chen et al.'s characterization of the cytokine storm in severe COVID-19 disease:
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@jclinicalinvest
Journal of Clinical Investigation
9 months
Macrophage–endothelial cell crosstalk orchestrates neutrophil recruitment in inflamed mucosa: @SumaginLab @NUFeinbergMed #CellBiology #Inflammation
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@jclinicalinvest
Journal of Clinical Investigation
11 months
IL-6 helps weave the inflammatory web during acute coronary syndromes: In this #Commentary , Tetsushi Nakao, and Peter Libby fit the results into an inclusive schematic for IL-6 effects following MI. Related:
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@jclinicalinvest
Journal of Clinical Investigation
3 years
The discovery of insulin revisited: lessons for the modern era: #Review by Gary F. Lewis and Patricia L. Brubaker @uoftmedicine in the #ReviewSeries : 100th Anniversary of Insulin's Discovery ()
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@jclinicalinvest
Journal of Clinical Investigation
3 years
#ReviewSeries edited by JCI’s Editor-in-chief @rex_ahima : 100th Anniversary of Insulin's Discovery: Reviews in this series address a modern understanding of insulin's role in metabolism and the pathophysiology and treatment of disease.
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@jclinicalinvest
Journal of Clinical Investigation
2 years
#Review : Targeting memory T cell metabolism to improve immunity: by @MauroCorradoBio and Erika L. Pearce in JCI's latest #ReviewSeries : Immunometabolism: @CECAD_ @HopkinsMedicine
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@jclinicalinvest
Journal of Clinical Investigation
5 years
Immune cells to the rescue! Innate and adaptive contributions to tissue repair Featuring reviews on epigenetics, immunometabolism, and the innate, immune, and epithelial cell contributions to repair
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@jclinicalinvest
Journal of Clinical Investigation
3 years
Obesity-linked reductions in adipose tissue oxygenation parallel reduced insulin sensitivity: @WUSTLmed #ClinicalMedicine #Metabolism
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@jclinicalinvest
Journal of Clinical Investigation
4 years
#ClinicalMedicine : Sleeping Beauty–engineered CAR T cells achieve antileukemic activity without severe toxicities: @unimib #clinicaltrials #hematology
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@jclinicalinvest
Journal of Clinical Investigation
3 years
#ClinicalMedicine : Residual beta cell function benefits type 1 diabetes hypoglycemic events: @GWtweets #Autoimmunity #Endocrinology
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@jclinicalinvest
Journal of Clinical Investigation
5 years
Molecules in Blood Spike Hours before Seizures - @sciam profiles @marionhogg2 @Futureneuro_ie 's research, published this summer in the JCI. (JCI article: )
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@jclinicalinvest
Journal of Clinical Investigation
5 years
This week, JCI and @JCI_Insight announce the Reviewer Rewards program, which recognizes the outstanding contribution of peer reviewers to our evaluation process. More details can be found here:
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@jclinicalinvest
Journal of Clinical Investigation
4 years
Understanding immune toxicity triggered by immune checkpoint inhibitors Michael Dougan and Massimo Pietropaolo review the immune-related adverse events (irAEs) associated with ICIs and clinical clues to irAE pathogenesis.
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@jclinicalinvest
Journal of Clinical Investigation
4 years
JUST PUBLISHED: Clinical and immunologic features in severe and moderate Coronavirus Disease 2019 Also: Savannah Pederson and Ya-Chi Ho comment on Chen et al.'s characterization of the cytokine storm in severe COVID-19 disease:
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@jclinicalinvest
Journal of Clinical Investigation
4 years
. @pauljmeakin @LeedsMedHealth : Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction: #Endocrinology #VascularBiology
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@jclinicalinvest
Journal of Clinical Investigation
3 years
Just Published: Multisystem inflammatory syndrome in children is driven by zonulin-dependent loss of gut mucosal barrier: @LaelYonker @MassGeneralNews @harvardmed #ClinicalMedicine #COVID_19 #Inflammation
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@jclinicalinvest
Journal of Clinical Investigation
4 years
#clinicalmedicine Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease @WUSTLmed #hepatology #metabolism
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@jclinicalinvest
Journal of Clinical Investigation
1 year
Conflicting interests: when whistleblowers profit from allegations of scientific misconduct: Read the #Editorial by @emmcnally , JCI's Editor in Chief
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@jclinicalinvest
Journal of Clinical Investigation
4 years
The new tool in fighting cancer: Antibiotics The antibiotic vancomycin’s effect on the gut microbiome can boost the body’s immune response (via @Penn_Today )
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@jclinicalinvest
Journal of Clinical Investigation
1 year
SARS-CoV-2 variants resistant to monoclonal antibodies in immunocompromised patients is a public health concern: In this #Commentary , @ACasadevall1 & @dfocosi discuss the emergence of immunity-evading SARS-CoV-2 variants. Related:
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@jclinicalinvest
Journal of Clinical Investigation
4 years
Just published a review in @JCI_insight : The complement system in #COVID_19 : friend and foe? @anuja_java @alhkim @WUNephrology @WUSTLmed
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@jclinicalinvest
Journal of Clinical Investigation
6 years
We are excited to announce that bioRxiv preprints can now be directly transferred to the JCI for consideration! For more information, please visit
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@jclinicalinvest
Journal of Clinical Investigation
4 years
Author's Take: MICAL1 constrains and protects against disease by oxidizing CaMKII: Mark Anderson @HopkinsMedicine explains latest research from their group: Article: Full video: #Cardiology #CellBiology
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@jclinicalinvest
Journal of Clinical Investigation
3 months
Hemorrhage-activated NRF2 in tumor-associated macrophages drives cancer growth, invasion, and immunotherapy resistance: @Unispital_USZ #Inflammation #Oncology
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@jclinicalinvest
Journal of Clinical Investigation
1 year
#Cover : Dual therapy increases survival in a pediatric high-grade glioma model: @castro2355_mg @umichmedicine Image credit: @Ella_Maru #Oncology #Therapeutics
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@jclinicalinvest
Journal of Clinical Investigation
2 years
#Review : Unpacking macrophages’ many interactions with the vasculature in atherosclerosis: @KateyRayner @LeahSusser @UOttawaMed
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@jclinicalinvest
Journal of Clinical Investigation
4 years
#ClinicalMedicine : Exebacase for patients with Staphylococcus aureus bloodstream infection and endocarditis: @DukeMedSchool #InfectiousDisease
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@jclinicalinvest
Journal of Clinical Investigation
2 years
#ClinicalMedicine : Inflammatory states predict progression to renal failure in lupus nephritis: @UCCancerCenter #Autoimmunity
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@jclinicalinvest
Journal of Clinical Investigation
4 years
Just Published: Antituberculosis BCG vaccination: more reasons for varying innate and adaptive immune responses: A Commentary by Sarah Prentice and Hazel M. Dockrell @LSHTM @enherts #Immunology #vaccines
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@jclinicalinvest
Journal of Clinical Investigation
3 years
On the Cover: Neonatal diabetes- and microcephaly-associated YIPF5 mutations cause increased ER stress: @Elisa_EDF @OtonkoskiT @athattersley @ExeterMed @ULBruxelles @helsinkiuni #CellBiology #Genetics
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@jclinicalinvest
Journal of Clinical Investigation
6 years
NEW REVIEW SERIES: Linking mitochondrial dysfunction to disease A collection of 7 reviews curated by the @NIH 's Michael Sack #mitochondria
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@jclinicalinvest
Journal of Clinical Investigation
4 years
#Review : Hypoxia-inducible factors and diabetes: A review by Jenny E. Gunton @Sydney_Uni in the #ReviewSeries :
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@jclinicalinvest
Journal of Clinical Investigation
1 year
Mitochondrial function in macrophages controls cardiac repair after myocardial infarction: David Weissman & @ChristophMaack highlight the metabolic mechanism by which macrophages regulate cardiac repair following myocardial infarction; #Commentary
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@jclinicalinvest
Journal of Clinical Investigation
6 years
This new review by Mark Herman et al. at @DukeHealth doesn't sugarcoat the role of fructose metabolism in metabolic disease: #obesity #diabetes #sugar
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@jclinicalinvest
Journal of Clinical Investigation
3 years
Author's Take: Gs/Gq signaling switch in β cells underlies the potential of incretins in diabetes: FULL VIDEO:  ARTICLE:  @KobeU_Global #Endocrinology #Metabolism
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@jclinicalinvest
Journal of Clinical Investigation
6 months
#Review : Recent advances in lung organoid development and applications in disease modeling: Ana I. Vazquez-Armendariz and Purushothama Rao Tata @Tatalab_Duke @DukeMedSchool @LIMES_Bonn
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@jclinicalinvest
Journal of Clinical Investigation
3 years
#ClinicalMedicine : Biomarkers of inflammation and repair in kidney disease progression: @KidneydrChirag @HopkinsMedicine #Inflammation #Nephrology
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@jclinicalinvest
Journal of Clinical Investigation
4 years
#ClinicalMedicine Influence of adiposity, insulin resistance, and intrahepatic triglyceride content on insulin kinetics @WUSTLmed #endocrinology #metabolism
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@jclinicalinvest
Journal of Clinical Investigation
4 years
Clinical insights into variable immune responses to BCG vaccination: , Two clinical trials led by Mihai G. Netea @Radboud_Uni interrogated heterogeneous immunological outcomes of BCG vaccination.
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@jclinicalinvest
Journal of Clinical Investigation
4 years
Assessing #COVID_19 ’s impact on New York City resident physicians: @ColumbiaMed Accompanying commentary: @yaron_tomer @EinsteinMed #InfectiousDiseases
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@jclinicalinvest
Journal of Clinical Investigation
4 years
Changing the editorial process at JCI and JCI Insight in response to the COVID-19 pandemic and its effects on the worldwide scientific community:
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@jclinicalinvest
Journal of Clinical Investigation
2 years
A mitochondrial unfolded protein response inhibitor suppresses prostate cancer growth in mice via HSP60: @RoswellPark #CellBiology #Oncology
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@jclinicalinvest
Journal of Clinical Investigation
3 years
ICYMI: #ReviewSeries : Circadian rhythm’s wide-ranging impact on human health and disease: This collection of reviews, curated by Amita Sehgal @PennMedicine considers the critical role of the circadian system in human health.
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@jclinicalinvest
Journal of Clinical Investigation
4 years
Just published in @JCI_insight : Cytokine profile in plasma of severe #COVID19 does not differ from ARDS and sepsis: @StanfordMed #ClinicalMedicine #InfectiousDisease
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@jclinicalinvest
Journal of Clinical Investigation
5 years
Many congratulations to JCI's deputy editor Gregg Semenza on this well-deserved recognition!
@NobelPrize
The Nobel Prize
5 years
BREAKING NEWS: The 2019 #NobelPrize in Physiology or Medicine has been awarded jointly to William G. Kaelin Jr, Sir Peter J. Ratcliffe and Gregg L. Semenza “for their discoveries of how cells sense and adapt to oxygen availability.”
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Journal of Clinical Investigation
4 years
ICYMI: #ClinicalMedicine : Early safety indicators of #COVID_19 convalescent plasma in 5,000 patients: @DrMJoyner @ACasadevall1
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@jclinicalinvest
Journal of Clinical Investigation
2 years
SIRT6 protects against vascular calcification in chronic kidney disease: #CellBiology #VascularBiology
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@jclinicalinvest
Journal of Clinical Investigation
3 years
#ClinicalMedicine : Tobacco smoking induces metabolic reprogramming of renal cell carcinoma: @UCHealthNews #Metabolism #Oncology
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@jclinicalinvest
Journal of Clinical Investigation
3 years
. @UshmaNeill interviews @DanielJDrucker @sinaihealth @uoftmedicine in the latest episode of JCI's Conversations with Giants in Medicine: Full Video:
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@jclinicalinvest
Journal of Clinical Investigation
4 years
β3-adrenergic receptor agonist improves glucose homeostasis in two human trials (thread)
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@jclinicalinvest
Journal of Clinical Investigation
10 months
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@jclinicalinvest
Journal of Clinical Investigation
2 years
Indoxyl sulfate in uremia: an old idea with updated concepts: Anders H. Berg, Sanjeev Kumar, S. Ananth Karumanchi discuss the link between IS and PAD and suggest possibilities for improving clinical outcomes. #Commentary @CedarsSinai @BIDMChealth
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@jclinicalinvest
Journal of Clinical Investigation
9 months
#Review : The lung mesenchyme in development, regeneration, and fibrosis: by @ElieElAgha & Victor J. Thannickal in the JCI's latest review series on "Lung inflammatory injury and tissue repair":
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@jclinicalinvest
Journal of Clinical Investigation
9 months
Antigen-presenting aged neutrophils induce CD4+ T cells to exacerbate inflammation in sepsis: @NorthwellHealth #CellBiology #Immunology
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@jclinicalinvest
Journal of Clinical Investigation
6 months
Dietary potassium stimulates Ppp1Ca-Ppp1r1a dephosphorylation of kidney NaCl cotransporter and reduces blood pressure: @PAWellingMD @HopkinsMedicine #Nephrology
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@jclinicalinvest
Journal of Clinical Investigation
4 years
In @JCI_insight : Severe immunosuppression and not a cytokine storm characterizes #COVID_19 infections: @WUSTLmed #InfectiousDisease
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@jclinicalinvest
Journal of Clinical Investigation
4 years
The 2019 Nobel Prize honors fundamental discoveries in hypoxia response @CardioOncology and @KimrynRathmell discuss the discoveries of Professors Sir Peter Ratcliffe @UniofOxford , Gregg Semenza @HopkinsMedicine , and William Kaelin Jr. ( @DanaFarber ).
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@jclinicalinvest
Journal of Clinical Investigation
2 years
#Cover : Visualizing the cardiac conduction system: Image: an intact wild-type heart (gray) from a mouse injected with mCntn2-800 (gold), illuminating the entire cardiac conduction system in vivo. @Will_Goodyer @SeanM_Wu @StanfordMed #Cardiology
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@jclinicalinvest
Journal of Clinical Investigation
2 years
KRAS mutations as essential promoters of lymphangiogenesis via extracellular vesicles in pancreatic cancer: In this #Commentary , @RaduPirlogMD & @GeorgeACalin1 @MDAndersonNews provide a model for KRASG12D-induced lymphangiogenesis in PDAC.
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@jclinicalinvest
Journal of Clinical Investigation
3 years
B cells join T cell clusters in the host response to recurrent herpes simplex virus 2 infection: In this #Commentary , @JeffGehlhausen & @VirusesImmunity @YaleMed highlight role for antibody producing cells & B cells following HSV-2 reactivation
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@jclinicalinvest
Journal of Clinical Investigation
2 years
#Review : Metabolic changes in aging humans: current evidence and therapeutic strategies: in JCI's latest #ReviewSeries on Aging: @allysonkpalmer @MayoClinic
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@jclinicalinvest
Journal of Clinical Investigation
3 years
Perineuronal net degradation rescues CA2 plasticity in a mouse model of Rett syndrome: @NIH #Development #Neuroscience
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@jclinicalinvest
Journal of Clinical Investigation
7 years
Review Series on Metabolism and Inflammation: 10 reviews on the link between inflammation and metabolic dysfunction
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@jclinicalinvest
Journal of Clinical Investigation
4 months
A gain-of-function p53 mutant synergizes with oncogenic NRAS to promote acute myeloid leukemia in mice: @UWMadison #Hematology
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@jclinicalinvest
Journal of Clinical Investigation
4 years
#ClinicalMedicine : Boosting NAD level suppresses inflammatory activation of PBMCs in heart failure: @Rongtian2 @UWMedicine #Cardiology #Inflammation
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@jclinicalinvest
Journal of Clinical Investigation
3 years
The key role of NLRP3 and STING in APOL1-associated podocytopathy: @KSusztak @PennMedicine #CellBiology #Nephrology
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@jclinicalinvest
Journal of Clinical Investigation
3 years
Preferential Gq signaling in diabetes: an electrical switch in incretin action and in diabetes progression? In this #Commentary , Colin Nichols, Nathaniel York, & Maria Remedi provide insights into T2D progression. Related article:
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@jclinicalinvest
Journal of Clinical Investigation
3 years
#ClinicalMedicine : Pharmacogenomics of intracellular methotrexate polyglutamates in patients’ leukemia cells in vivo: @StJudeResearch #Hematology
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@jclinicalinvest
Journal of Clinical Investigation
1 month
PI3K/mTOR is a therapeutically targetable genetic dependency in diffuse intrinsic pontine glioma: @MattDun17 @childrenshealth @Uni_Newcastle #Oncology #Therapeutics
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@jclinicalinvest
Journal of Clinical Investigation
6 years
REVIEW SERIES: Emerging roles for lipid mediators in health and disease Curated by series editor Charles Serhan.
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@jclinicalinvest
Journal of Clinical Investigation
4 years
Clinical and immunological features of severe and moderate coronavirus disease 2019 Plus: @HoLabHIV 's commentary: SARS-CoV-2: a storm is raging
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@jclinicalinvest
Journal of Clinical Investigation
1 year
#ReviewSeries : Understanding & exploiting the immune microenvironment in glioblastoma: JCI editors @HeimbergerAmy @DanielJBrat @maciejlesniakmd curated the reviews to confront the many aspects of immune involvement in clinically challenging tumors.
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@jclinicalinvest
Journal of Clinical Investigation
2 years
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@jclinicalinvest
Journal of Clinical Investigation
3 years
Targeting the αv integrin/TGF-β axis improves natural killer cell function against glioblastoma stem cells: @MDAndersonNews #Immunology
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@jclinicalinvest
Journal of Clinical Investigation
10 months
Fibroblasts suppress T cells in diffuse large B cell lymphoma: @RamsayLab @KingsCollegeLon #Immunology #Oncology
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@jclinicalinvest
Journal of Clinical Investigation
4 years
Just Published: Baricitinib restrains the immune dysregulation in severe #COVID_19 patients: @UniVerona #ClinicalMedicine #InfectiousDiseases
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@jclinicalinvest
Journal of Clinical Investigation
9 months
#Cover : Monocyte-derived macrophages in necrotic liver lesion repair: Image: multiplex immunofluorescence staining of liver tissue 96 hours after concanavalin A–induced liver injury. @NIAAAnews #Gastroenterology #Hepatology
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@jclinicalinvest
Journal of Clinical Investigation
4 years
Hypoxia-inducible factors in human disease physiology and therapeutics: This #ReviewSeries created by JCI’s deputy editor Gregg Semenza highlights how #HIFs contribute to the pathogenesis and treatment of human disease.
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@jclinicalinvest
Journal of Clinical Investigation
3 years
Tanycytic network supplies hypothalamic neurons with lactate to regulate energy: @NeuroendoLille #Metabolism #Neuroscience
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@jclinicalinvest
Journal of Clinical Investigation
3 years
YIPF5 mutations cause neonatal diabetes and microcephaly through endoplasmic reticulum stress: @Elisa_EDF @OtonkoskiT @athattersley @ExeterMed @ULBruxelles @helsinkiuni #CellBiology #Genetics
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@jclinicalinvest
Journal of Clinical Investigation
4 years
#ClinicalMedicine : Haploinsufficiency of immune checkpoint receptor CTLA4 induces a distinct neuroinflammatory disorder: @NINDSnews @NIAIDNews #Inflammation #Neuroscience
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@jclinicalinvest
Journal of Clinical Investigation
4 years
Interacting hepatic PAI-1/tPA gene regulatory pathways influence impaired fibrinolysis severity in obesity: @ColumbiaMed #Hematology #Metabolism
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@jclinicalinvest
Journal of Clinical Investigation
1 year
Canagliflozin primes antitumor immunity by triggering PD-L1 degradation in endocytic recycling: #Immunology
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@jclinicalinvest
Journal of Clinical Investigation
3 years
YIPF5 mutations cause neonatal diabetes and microcephaly: progress for precision medicine and mechanistic understanding: A #Commentary by @tonipollin and Simeon I. Taylor discussing recent study by De Franco and Lytrivi et al.:
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@jclinicalinvest
Journal of Clinical Investigation
3 years
On the Cover: Inhibiting isocitrate dehydrogenase 1 mutant glioma: Image: small molecule inhibition of 2HG production promoted T cell response to glioma, which led to enhanced immunological memory & survival. Credit: @Ella_Maru @castro2355_mg @umichmedicine
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@jclinicalinvest
Journal of Clinical Investigation
4 years
12(S)-HETE mediates diabetes-induced endothelial dysfunction by activating intracellular endothelial cell TRPV1: @UK_Muenster #VascularBiology
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@jclinicalinvest
Journal of Clinical Investigation
2 years
The L-kynurenine pathway links impaired renal reserve with preeclampsia pathogenesis: @CedarsSinai #Nephrology #ReproductiveBiology
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@jclinicalinvest
Journal of Clinical Investigation
2 months
#Commentary : Yoda1 opens the lymphatic path for craniosynostosis therapy: @aleaspel and Kari Alitalo @helsinkiuni Related article:
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@jclinicalinvest
Journal of Clinical Investigation
2 years
#Cover : Efferocytosis induces macrophage-produced VEGFC to ameliorate cardiac injury & inflammation: Image: cardiac macrophages (CD68-red) & lymphatic vessel endothelial cells (LYVE1-green) in murine cardiac sections @NU_Lymphatics @WanshuMa @NUFeinbergMed
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