Marson Lab @MarsonLab Twitter profile

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Marson Lab

@MarsonLab

2 years

Very excited to see our newest work out today in @Nature led by @bapat_lab , who found that obesity starkly changes organismal immune state and can flip the type of T cell inflammatory response with crucial impacts on biologic treatment approaches

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Marson Lab

@MarsonLab

2 years

Excited to share another paper out this week from our lab in @NatureBiotech - High-yield genome engineering in primary cells using a hybrid ssDNA repair template and small-molecule cocktails,

High-yield genome engineering in primary cells using a hybrid ssDNA repair template and small-mol...

Nature Biotechnology - Combinations of single-stranded DNA repair templates and small molecules markedly enhance genome editing.

www.nature.com

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Marson Lab

@MarsonLab

2 years

Extremely excited to share our work out in @Nature today: RASA2 ablation in T cells boosts antigen sensitivity and long-term function

RASA2 ablation in T cells boosts antigen sensitivity and long-term function

Nature - Genome-wide CRISPR screens, biochemical studies and animal models show that RASA2 has a key role in regulating T cell function and has potential as a genetic target for enhancing...

www.nature.com

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Marson Lab

@MarsonLab

8 months

Extremely excited to share our work led by @FranziBlaeschke and Theo Roth out in @CellCellPress today! Using Modular Pooled Knockin (ModPoKI) we screened up to ~10,000 synthetic knockin sequences at the same time to improve TCR or CAR T cells. 1/12

Modular pooled discovery of synthetic knockin sequences to program durable cell therapies

Modular pooled knockin screening (ModPoKI) is an adaptable platform that enables the evaluation of hundreds to thousands of different T cell constructs for engineered cellular immunotherapies.

www.cell.com

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Marson Lab

@MarsonLab

2 years

My father read the NY Times obits every day. He loved learning people's stories. Here's an obit that he would have enjoyed. I will forever be inspired by my Dad.

Bernard Marson, a Catalyst for SoHo’s Renaissance, Dies at 91 (Published 2022)

An architect and developer, he helped pioneer the neighborhood’s transition from manufacturing into lofts where artists could work and live.

www.nytimes.com

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Marson Lab

@MarsonLab

4 years

Big news to share! Today we launch a new UCSF-Gladstone Institute dedicated to Genomic Immunology. We will foster creativity and collaboration to accelerate fundamental discoveries and innovation in immunotherapies. @ucsf @GladstoneInst

Two New Research Institutes in the Bay Area

Scientists at Gladstone and UCSF launch new efforts in virology and genomic immunology

gladstone.org

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Marson Lab

@MarsonLab

3 years

Excited to share our latest progress on non-viral human T cell engineering:

Hybrid ssDNA repair templates enable high yield genome engineering in primary cells for disease...

CRISPR-Cas9 offers unprecedented opportunities to modify genome sequences in primary human cells to study disease variants and reprogram cell functions for next-generation cellular therapies. CRISPR...

www.biorxiv.org

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Marson Lab

@MarsonLab

4 years

Our lab's new paper out today in CELL: Now CRISPR can install many different DNA "programs" into human T cells. This allows us to iterate faster than ever before & discover new synthetic DNA sequences for immunotherapies. Congrats Theo Roth & collaborators

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Marson Lab

@MarsonLab

5 months

In @Nature : Forward genetics in human immune cells can now discover alleles to tune disease-relevant phenotypes. Functional insights into pathogenic patient variants and specific amino-acids in protein complexes, and a path to accelerate design of immunotherapies! #CRISPR

ralf schmidt

@R_Schmidt_

5 months

Excited to share a milestone in our forward genetics developments! Today in @Nature we report massive mutagenesis screening in T cells with base editors, increasing resolution from genes to nucleotides A @MarsonLab story with my dear friend @carlcward 1/10

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Marson Lab

@MarsonLab

1 year

So excited about @j_eyquem lab's new paper out in @CellCellPress today: An evolved AAV variant enables efficient genetic engineering of murine T cells. Already spawning new, exciting collaborations @GladstoneInst , @UCSF and elsewhere!

An evolved AAV variant enables efficient genetic engineering of murine T cells

By combining structure-guided evolution and genome-wide screening, this work identifies an adeno-associated virus and co-factor that enable gene targeting at high efficiencies in mouse T lymphocytes,...

www.cell.com

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Marson Lab

@MarsonLab

9 months

New from @MuradRMamedov in in Nature today! #CRISPR screens show how cancer cells can be recognized & killed by human gamma delta T cells. Great collaboration w @UChiAdamsLab @JKuball @ZsoltSebestyen2 @jkpritch & Avinash Sahu!

How Unique Immune Cells Can Recognize—and Destroy—Tumors

New study explains how understudied cells in the immune system, called gamma delta T cells, can target cancer cells for destruction

gladstone.org

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Marson Lab

@MarsonLab

2 years

Excited to share our new @biorxivpreprint work led by @FranziBlaeschke and Theo Roth: Using new Modular Pooled Knockin (ModPoKI) technology, we screened up to ~10,000 synthetic knockin sequences at the same time to improve TCR or CAR T cells. 1/11

Modular Pooled Discovery of Synthetic Knockin Sequences to Program Durable Cell Therapies

Chronic stimulation can cause T cell dysfunction and limit efficacy of cellular immunotherapies. CRISPR screens have nominated gene targets for engineered T cells, but improved methods are required...

www.biorxiv.org

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Marson Lab

@MarsonLab

3 years

Excited to share a big advance in our latest preprint - Ralf Schmidt and Zach Steinhart @CrisprEh figured out how to do CRISPRa and CRISPRi screens in primary human cells, generating a system to accelerate discovery of genes to improve T cell therapies:

CRISPR activation and interference screens in primary human T cells decode cytokine regulation

The pathways that regulate cytokine responses in T cells are disrupted in autoimmunity, immune deficiencies, and cancer, and include immunotherapy targets. Systematic discovery of cytokine regulators...

www.biorxiv.org

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Marson Lab

@MarsonLab

3 years

Excited to share our latest work w/ @jkpritch led by @JakeFreimer & Oren Shaked to systematically define gene regulatory networks around key immune genes. Integrating CRISPR screening w/ ATACseq & RNAseq we define both the upstream regulators & comprehensive downstream networks.

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Marson Lab

@MarsonLab

2 years

CRISPRa&CRISPRi are now a Rosetta Stone teaching the language of DNA in human T cells. Switching on or off every gene in the genome, we quickly learn which genes control which functions. Next we'll write code in the language for new cell therapies. Congrats @CrisprEh & @R_Schmidt_

Zach Steinhart

@CrisprEh

2 years

Thrilled to have our recent work from the @marsonlab published in @ScienceMagazine . This was the result of an awesome collaboration between myself and fellow Marson Lab postdoc, @R_Schmidt_ (1/12)

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Marson Lab

@MarsonLab

3 years

Now CRISPR RNPs work in human myeloid cells too. We can start to discover genes with important functions in response to pathogens, vaccines, and cancers. Congrats to @Hiattsmejoe and @dvero_ . And thanks to awesome collaboration with @KroganLab

Efficient generation of isogenic primary human myeloid cells using CRISPR-Cas9 ribonucleoproteins

Hiatt et al. report a method for genome editing in primary human monocytes using CRISPR-Cas9 ribonucleoproteins (RNPs). These cells can be differentiated into macrophages or dendritic cells for...

www.cell.com

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Marson Lab

@MarsonLab

1 year

Feeling very proud to be an @ArsenalBio co-founder. Watching this team push toward CRISPR-engineered immunotherapies has been exhilarating. This is a major milestone. Hoping that many will benefit.

ArsenalBio

@ArsenalBio

1 year

The first patient has been dosed with AB-1015 in a Phase 1, first-in-human clinical trial for patients with ovarian cancer that is resistant to platinum-based regimens. It is our first internally discovered T cell medicine to enter clinical development:

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Marson Lab

@MarsonLab

1 year

Talking CRISPR at sunset with @hongbo_chi . #asilomar

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Marson Lab

@MarsonLab

4 years

Our assessment of COVID-19 antibody tests is now @naturebio . Great collaboration with @pdhsu , @UCSF , @czbiohub , @igisci , @ZSFGCare , @MassGenBrigham , and many volunteers. We still need cheaper, faster, better and more scalable viral diagnostics.

Nature Biotechnology

@NatureBiotech

4 years

Evaluation of #SARSCoV2 serology assays reveals a range of test performance

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Marson Lab

@MarsonLab

6 years

Grateful that WIRED and Sean Parker share our excitement about the potential of CRISPR-reprogrammed immune cells to expand how we treat disease. Thanks to folks in the lab and wonderful collaborators who are pushing this work forward. AM.

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Marson Lab

@MarsonLab

1 year

Excited to share our new collaborative work with @RossWilsonLab & @j_eyquem out now in @natBME - Peptide-mediated delivery of CRISPR enzymes for the efficient editing of primary human lymphocytes - led by @dv_foss , @JoeJMuldoon , & David Nguyen (OA link)

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Marson Lab

@MarsonLab

3 years

If you're looking for a holiday podcast, I got a chance to go deep into T cells, CRISPR, autoimmune diseases, cancer immunotherapy and my career path with @PTurnbaugh . Peter, thanks for underscoring all the ways Science is Fun #SIF @immunox @UCSF @GladstoneInst

Peter Turnbaugh

@PTurnbaugh

4 years

#SIF Alex Marson @MarsonLab @UCSF @GladstoneInst , discusses his work on #COVID19 serological tests and bringing #CRISPR technologies to the clinic:

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Marson Lab

@MarsonLab

3 years

"CAR Pooling" accelerates design of CAR T cells. Pooled screens and single cell analysis reveal novel receptors that we hope will improve treatments. Amazing collaborative effort led by @dbgoodman and @CamilliaAzimi with @kickassscience1 and ArsenalBio co-founder @KoleRoybal .

Daniel Bryan Goodman

@dbgoodman

3 years

Excited to share new work w/ co-lead @CamilliaAzimi , @MarsonLab @kickassscience1 @roybal_lab : using a method we call 'CAR Pooling', we tested many CARs in multiplex & found new non-T cell signaling domains which improve CAR-T efficacy. 👇🧵 1/10

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Marson Lab

@MarsonLab

1 year

Excited to share the story of the @GladstoneInst @UCSF Institute of Genomic Immunology - what we’ve been building over the past two years and where we’re heading in the years to come!

Re-Engineering the Human Immune System

Researchers at the Gladstone-UCSF Institute of Genomic Immunology are learning how to harness the power of the human immune system in new ways

gladstone.org

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Marson Lab

@MarsonLab

8 months

Thank you so much for this honor! Thrilled to be building a @parkerici site @GladstoneInst to develop next-gen cancer cell therapies.

Parker Institute for Cancer Immunotherapy

@parkerici

8 months

Congratulations to Alex Marson, MD, PhD, @MarsonLab Center Director for PICI @GladstoneInst for being named to the 2023 @PharmaVoice 100 list as one of the most inspiring people in the life sciences industry. We’re proud to partner with you. #PICINetwork

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Marson Lab

@MarsonLab

3 years

Always exciting to collaborate with @doudna_lab ! @JRo_Hamilton and @connortsuchida developed cool new particles to deliver CRISPR, and Brian Shy and David Nguyen used them in human T cells. Could be a step towards in vivo editing in future immunotherapies! @GladstoneInst @igisci

Innovative Genomics Institute

@igisci

3 years

In a new paper in @CellReports , IGI researchers from @doudna_lab and @MarsonLab mimic viruses to sneak #CRISPR into cells. Learn more from first authors @JRo_Hamilton & @connortsuchida (who made this cool image!):

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Marson Lab

@MarsonLab

2 years

BIG NEWS FOR THE GLADSTONE-UCSF INSTITUTE OF GENOMIC IMMUNOLOGY! Welcome, Ansu @Satpathology . Looking forward to what we'll discover together.

Ansu Satpathy

@Satpathology

2 years

Excited to announce that our lab is joining the Gladstone Institute of Genomic Immunology! Looking forward to teaming up with @Marsonlab to pursue the next generation of genomics-inspired immunotherapies and bridging @StanfordMed @parkerici and @Gladstone communities.

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Marson Lab

@MarsonLab

4 years

Two enhancers of same gene w/ opposite effects on autoimmune disease! W/ @iamdimitre , @HarikeshWong & Ron Germain we show IL2RA enhancer mutations skew balance of IL2 signals in Tregs and conventional T cells. Provides insight into a common human SNP.

T cell subset-selective IL2RA enhancers shape autoimmune diabetes risk

The majority of genetic variants associated with complex human autoimmune diseases reside in enhancers[1][1]–[3][2], non-coding regulatory elements that control gene expression. In contrast with...

www.biorxiv.org

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Marson Lab

@MarsonLab

11 months

Working for years w/ @HarikeshWong , @iamdimitre , Kyemyung Park, @TsangLab & Ron Germain on how non-coding variation affects disease. We now found fragility in intra- and intercellular IL2 feedback circuitry that dramatically shapes autoimmunity risk.

Non-coding sequence variation reveals fragility within interleukin 2 feedback circuitry and shapes...

Genetic variants associated with human autoimmune diseases commonly map to non-coding control regions, particularly enhancers that function selectively in immune cells and fine-tune gene expression...

www.biorxiv.org

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Marson Lab

@MarsonLab

9 months

So wonderful to visit with @UjRathore parents this week, who were able to come see the incredible work their son is doing in my lab @GladstoneInst investigating HIV host-pathogen interactions w/CRISPR!

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Marson Lab

@MarsonLab

3 years

Congrats to newly minted Dr. Joe Hiatt! Joe has already has made major contributions to understanding host-pathogen interactions, including shedding light on COVID-19. Over 100 friends, family, and fans showed up virtually for awesome talk. @GladstoneInst @immunox

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Marson Lab

@MarsonLab

4 years

Happy halloween! @doudna_lab , this brought me a big smile today. Very lucky to have a true superhero as a colleague and collaborator. @igisci @GladstoneInst @UCSF

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Marson Lab

@MarsonLab

3 years

XYZeq provides single cell RNA sequencing and assigns each cell to its spatial location in a tissue specimen. Hoping this will be widely adopted for research and pathology studies of the future. Great collaboration with @yimmieg and Eric Chow led by Youjin Lee and Derek Bogdanoff

Jimmie Ye

@yimmieg

3 years

Excited to share XYZeq, a single-cell RNA-seq workflow that also resolves the spatial location of each cell: . XYZeq was jointly developed with @MarsonLab , Eric Chow and lead by an incredible team of trainees (Youjin Lee, Derek Bogdanoff, Yutong Wang).(1/n)

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Marson Lab

@MarsonLab

3 years

Check out our updated lab website: Goodbye to the version I made when I taught myself Drupal before starting the lab in 2013. This does better justice to the scientific momentum of current lab members and collaborators. @GladstoneInst @ucsf @immunox

Marson Lab

Decoding and rewriting human immune cells with CRISPR

www.marsonlab.org

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Marson Lab

@MarsonLab

1 year

Congratulations to Justin Eyquem @j_eyquem on his @ASGCTherapy Outstanding New Investigator Award! So happy to have you on our @GladstoneInst @UCSF Genomic Immunology team!

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Marson Lab

@MarsonLab

6 years

Pleased to share our genome wide screening platform for human T cell immunotherapy target discovery: Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function

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Marson Lab

@MarsonLab

4 years

We're sharing new methods to CRISPR-edit human myeloid immune cells. Hoping this helps to accelerate studies of infections and vaccine development efforts. Congrats to Joe Hiatt who led this effort in collaboration with Nevan Krogan's lab. @igisci

Efficient Generation of Isogenic Primary Human Myeloid Cells using CRISPR-Cas9 Ribonucleoproteins

Genome engineering of primary human cells with CRISPR-Cas9 has revolutionized experimental and therapeutic approaches to cell biology, but human myeloid-lineage cells have remained largely genetica...

www.biorxiv.org

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Marson Lab

@MarsonLab

4 years

@NatImmunol : CRISPR & single-cell RNAseq points to a functional genomic map for engineering next-gen human regulatory T cell (Treg) therapies. Led by Kathrin Schumann & @sidsraju . Great collaboration w/ @yimmieg , @SpitzerLab , @kickassscience1 , @QizhiTang

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Marson Lab

@MarsonLab

4 years

Enormous congratulations to Jennifer Doudna & Emmanuelle Charpentier on the Nobel Prize for CRISPR DNA editing! Their discovery has transformed biology and medicine. So glad to their breakthrough recognized. @igisci @GladstoneInst @UCSF @doudna_lab

Nobel Prize in Chemistry Awarded to 2 Scientists for Work on Genome Editing (Published 2020)

Emmanuelle Charpentier and Jennifer A. Doudna developed the Crispr tool, which can change the DNA of animals, plants and microorganisms with high precision.

www.nytimes.com

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Marson Lab

@MarsonLab

4 years

Proud to be part of this team - working to determine reliability of Covid-19 antibody tests. Lots of work ahead. Thanks to amazing grad students, postdocs, staff & @czbiohub @igisci @ucsf @pdhsu . More on our website - & @nytimes :

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Marson Lab

@MarsonLab

3 years

Friend & co-founder @nickhaining joins @ArsenalBio leadership! "The sketch on the back of a cocktail napkin we drew w/ @EJohnWherry @MarsonLab @KoleRoybal @BradEBernstein et al is now a full-stack company ready to program the fate and function of T cells to cure cancer" -Nick

Nick Haining

@nickhaining

3 years

So, some news: I’m unreasonably excited to be joining the all-star team at @Arsenalbio as CSO (1/n)

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Marson Lab

@MarsonLab

4 years

Congratulations to David Nguyen and Theo Roth and wonderful collaborators on improved genome targeting across diverse human blood cell types with polymer-stabilized Cas9 nanoparticles and modified HDR templates.

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Marson Lab

@MarsonLab

3 years

Big day for cell therapy! "Living therapeutics" use cells to restore tissue damaged by age or disease, super-charge the immune system to fight diseases, and more. @UCSF 's new initiative means this cutting-edge medicine can reach patients faster. #ucsfLTI

Living Therapeutics Initiative Will Accelerate Development and Delivery of Revolutionary Treatments

UCSF is launching a new initiative to propel the development of living therapeutics – a category of treatments broadly defined as human and microbial living cells that are selected, modified, or...

www.ucsf.edu

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Marson Lab

@MarsonLab

2 years

Very excited to announce @GladstoneInst joining forces with @parkerici as a new PICI research center! Genomic immunology has incredible potential for the design and generation of next-gen cellular therapies - PICI will help us get there.

PICI Welcomes Dana-Farber and Gladstone Institutes to its Network of Leading Experts Advancing...

The Parker Institute for Cancer Immunotherapy (PICI), a network of the largest concentration of immuno-oncology (IO) expertise in the world, has added Dana-Farber Cancer Institute and Gladstone...

www.parkerici.org

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Marson Lab

@MarsonLab

4 years

Congrats to Dr. @jessicatcortez !! Going virtual for her defense today didn't slow her down. Almost one hundred people turned out to hear about her CRISPR screen in regulatory T cells & promising new immunotherapy targets. Jess, we're gonna miss you! @ucsf @GladstoneInst @immunox

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Marson Lab

@MarsonLab

4 years

Thanks to @donlemon @CNN for having me and @pdhsu on last night to discuss some complicated matters on COVID19 antibody testing.

CNN Tonight

@CNNTonight

4 years

Out of 12 antibody tests that were studied by the COVID-19 Testing Project, one gave false positives more than 15% of the time. Three other tests gave false positives more than 10% of the time.

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Marson Lab

@MarsonLab

4 years

The Gladstone-UCSF Institute of Genomic Immunology is recruiting faculty! Looking for leaders in immunology, genomics, genetics, genome engineering, synthetic biology and clinical immunotherapy. Building a team for discovery, innovation and cures.

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Marson Lab

@MarsonLab

5 years

Excited to share major improvements to CRISPR non-viral targeting in human immune cells from team led by David Nguyen and Theo Roth in the lab. Hope this proves widely useful and moves us closer to more engineered immune cell cures.

A Cas9 nanoparticle system with truncated Cas9 target sequences on DNA repair templates enhances...

Virus-modified T cells are approved for cancer immunotherapy, but more versatile and precise genome modifications are needed for a wider range of adoptive cellular therapies[1][1]–[4][2]. We recently...

www.biorxiv.org

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Marson Lab

@MarsonLab

4 years

Our new paper out in Nature: Jess Cortez and collaborators found new genes with potential to be developed into immunotherapies for cancer or autoimmune diseases. CRISPR screen in regulatory T cells with Deyu Fang, Elena Montauti, @NorthwesternU & @UCSF

CRISPR screen in regulatory T cells reveals modulators of Foxp3

Nature - A CRISPR-based screening platform was used to identify previously uncharacterized genes that regulate the regulatory T cell-specific master transcription factor Foxp3, indicating that this...

www.nature.com

Jessica Cortez, PhD

@jessicatcortez

4 years

I am incredibly proud and excited to share the culmination of my PhD work mapping Treg genetic modulators with CRISPR finally out today in Nature! @MarsonLab

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Marson Lab

@MarsonLab

4 years

Talking CRISPR, T cell immunotherapy & the first-in-human trial from UPenn's @carlhjune and @parkerici . Thanks to @MarkusElsner1 and @NatureBiotech for having me on.

Nature Biotechnology

@NatureBiotech

4 years

New #NBTForum podcast: Senior Editor @MarkusElsner1 talks to Alex Marson @UCSF about the significance of a @ScienceMagazine paper describing the phase 1 clinical trial of #CRISPR -engineered T cells

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Marson Lab

@MarsonLab

4 years

Proud to have a chance to share work from our lab and Gladstone-UCSF Institute for Genomic Immunology this morning at the opening session of the AACR conference. #AACR20 #cancerresearch #immunotherapy @UCSF @GladstoneInst @parkerici @igisci

Leticia De Mattos-Ar

@demattosarruda

4 years

👏📢Decoding and reprogramming T cell genomes. Important insights to the field while using CRISPR ✂️✂️Genome engineering for personalizing immunotherapy #AACR20 #immunotherapy #cancerresearch @MarsonLab @OncoAlert

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Marson Lab

@MarsonLab

3 years

Feeling inspired by @UjRathore : His COVID19 vaccine advocacy in India has potential to save thousands and thousands of lives. @GladstoneInst @UCSFHospitals @UCSF_ID

Gladstone Scientist Uses YouTube to Fight COVID-19 Misinformation in India

Unable to return to his home country during the COVID-19 surge in India, a Gladstone postdoc took to YouTube to share useful information about the virus and how to stay protected

gladstone.org

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Marson Lab

@MarsonLab

2 years

Looking forward to this for a number of reasons, including the opportunity to catch up with my PhD Mentor @youngricka . Should be a great meeting!

AACR

@AACR

2 years

Reprogramming T Cells with CRISPR to Enhance Immunotherapy: Alexander Marson will address this topic in a keynote address at the AACR-JCA Joint Conference on Breakthroughs in Cancer Research (Dec 10-14, Maui, Hawaii). Learn more: #aacrJCA22 @MarsonLab

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Marson Lab

@MarsonLab

4 years

Starting to adapt CRISPR to understand COVID-19. Sharing early, but promising data from @Hiattsmejoe in collaboration with @KroganLab @TheOttLab , Greene Lab, @GladstoneInst , @immunox and @igisci in hopes it will be useful to global science community. #COVID2019 #SARSCoV2

Joe Hiatt

@Hiattsmejoe

4 years

n=1 prelim optimization of CRISPR editing in lung cell lines, >80-95% efficient. An effort from @MarsonLab facilitated by @KroganLab @TheOttLab Greene lab. Hopefully this will accelerate your #coronavirus studies, share widely. We're wrestling with Calu3, plz share culture tips!

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Marson Lab

@MarsonLab

2 years

Big news! 3 of the 6 new Cancer Research Institute STARs are members of the Gladstone-UCSF Institute of Genomic Immunology. Congrats to @SpitzerLab @KoleRoybal @Satpathology and other STARs recognized for their pioneering work in cancer immunotherapy.

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Marson Lab

@MarsonLab

8 months

Honored to be an @arcinstitute Ignite Award Recipient and join such a stellar collaborative group working to accelerate scientific discovery and translation!

Arc Institute

@arcinstitute

8 months

🧠At Arc, we believe great science happens when creative minds can pursue their boldest ideas. Today, we welcome new researchers to the Arc community to conduct curiosity-driven, collaborative research into complex diseases—from cancer to conditions like autoimmune dysfunction.

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Marson Lab

@MarsonLab

4 years

Excited to share work led by @jessicatcortez and Elena Montauti in Deyu Fang's lab. Now we can discover critical gene expression regulators in primary cells with CRISPR. Here found promising new targets for autoimmunity and cancer immunotherapies in Tregs.

CRISPR Screen in Regulatory T Cells Reveals Ubiquitination Modulators of Foxp3

Regulatory T cells (Tregs) are required to control immune responses and maintain homeostasis but are a significant barrier to anti-tumor immunity[1][1]. Conversely, Treg instability, characterized by...

www.biorxiv.org

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Marson Lab

@MarsonLab

3 years

Excited about our Genomic Immunology Institute symposium coming up Nov 3! Register to learn more about what we’ve been building and to hear about how we’re using genomic technologies to engineer immunotherapies and understand human immunity 👇

Stacie Dodgson, PhD

@StacieDodgson

3 years

So about that genomic immunology institute we've been building at @GladstoneInst @UCSF ... excited to say we now have faculty! We have labs! We have really cool research going on! Learn about all the cool stuff we're doing at our symposium on November 3:

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Marson Lab

@MarsonLab

2 years

Awesome work from postdoc @JakeFreimer , collaborative with @jkpritch is now out in @NatureGenet :

Jonathan Pritchard

@jkpritch

3 years

How can we systematically measure gene regulatory networks around key disease genes? Excited to share our new work using CRISPR KOs in primary T cells, with @MarsonLab , led by @JakeFreimer and Oren Shaked:

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Marson Lab

@MarsonLab

1 year

Exciting new study out now in @CellCellPress from @SpitzerLab @GladstoneInst @UCSF Genomic Immunology - Can Lymph Nodes Boost the Success of Cancer Immunotherapy?

Can Lymph Nodes Boost the Success of Cancer Immunotherapy?

A clinical trial showed that, rather than removing lymph nodes, leaving them intact could help immunotherapy activate tumor-fighting T cells in the lymph nodes.

www.ucsf.edu

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Marson Lab

@MarsonLab

2 months

Proud to build a new engine for drug discovery with The Column group and @carlcward @R_Schmidt_ & @StacieDodgson . Amazing momentum for the Site Therapeutics team gathering around this effort!

The Column Group on LinkedIn: Site Therapeutics | LinkedIn

The Column Group is excited to start recruiting for its newest company Site Therapeutics in partnership with Alex Marson. We are looking for candidates that…

www.linkedin.com

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Marson Lab

@MarsonLab

11 months

Looking forward to participating in this @CancerResearch webinar next week! The CRISPR Revolution: How Genomic Engineering is Transforming Cancer Immunotherapy:

The CRISPR Revolution: How Genomic Engineering is Transforming Cancer Immunotherapy - Cancer...

Dr. Alexander Marson, a CRI Lloyd J. Old STAR, highlights the potential of CRISPR technologies to transform cancer immunotherapy by enabling entirely new opportunities for research and immunotherapy...

www.cancerresearch.org

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Marson Lab

@MarsonLab

3 years

Exciting to see power of engineered cell circuits in pre-clinical solid tumor models from Gladstone-UCSF Institute of Genomic Immunology Member and Arsenal Co-Founder, @KoleRoybal

Science Translational Medicine

@ScienceTM

3 years

A new series of SynNotch-CAR T cells from @KoleRoybal lab outperforms conventional designs in mice with #ovariancancer and #mesothelioma , suggesting they could overcome several weaknesses of #CARTCell therapy for solid tumors. @UCSF @parkerici #CellTherapy

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Marson Lab

@MarsonLab

4 months

Don't miss the scholarship deadline for @KeystoneSymp Systems and Engineering Immunology: Advancing Immunological Insights in Health and Disease this April in Banff! Join my co-organizers @TsangLab @TurleyLabGNE and I for an exciting meeting.

Conferences | Keystone Symposia

www.keystonesymposia.org

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Marson Lab

@MarsonLab

3 years

Very much looking forward to this opportunity to hear the latest in Next-Generation Cell Therapies! Was proud to co-organize with @KoleRoybal and Yvonne Chen.

Keystone Symposia

@KeystoneSymp

3 years

Present alongside field experts at upcoming #eSymposia on #CellTherapy & #RegenerativeMedicine , organized by @KoleRoybal @MarsonLab & Dr. Yvonne Chen. Submit your abstract by 12/15 for program short talk consideration & 1/11 for ePoster display.

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Marson Lab

@MarsonLab

2 years

The @GladstoneInst @UCSF Institute of Genomic Immunology + the UCSF Diabetes Center @AtUcsf have a very exciting position now open for an independent fellow whose work centers around using genomic technology to understand autoimmunity!

JDRF Fellow | Diabetes Center at UCSF

diabetes.ucsf.edu

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Marson Lab

@MarsonLab

4 years

Apply to join us at the new Gladstone-UCSF Institute of Genomic Immunology! 👇

Stacie Dodgson, PhD

@StacieDodgson

4 years

Don't forget to apply for our faculty search @GladstoneInst @UCSFMedicine in genomic immunology - looking for anyone with an interest in computational or experimental genomics, immunology, genome engineering, or similar! Not sure if you're ready? Apply anyway!

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Marson Lab

@MarsonLab

3 years

Join the Gladstone-UCSF Institute of Genomic Immunology on Jan 22 for an online symposium highlighting the next generation of leaders at the intersection of genomics and immunology. Keynote talks from Ananda Goldrath @GoldrathLab & Avery Poser @IAmDrDex

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Marson Lab

@MarsonLab

1 year

Thanks to @heidiledford and @Nature for capturing the potential and the challenges of T cell therapies. Thrilled to be racing towards better treatments in collaboration with so many amazing scientists.

Cancer Research Institute

@CancerResearch

1 year

Discover "the race to supercharge cancer-fighting T cells," and explore how CRI Lloyd J. Old STAR Dr. Marson @MarsonLab @GladstoneInst and CRI Scientific Advisory Council member Dr. June @PennMedicine are making a direct impact: #CART #CancerResearch

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Marson Lab

@MarsonLab

1 year

Excited to give a @QB3 webinar today at 1 PT: Decoding and Reprogramming Immune Cell Circuits with CRISPR - hope you can join!

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Marson Lab

@MarsonLab

3 years

Truly honored to get a chance to talk about the Gladstone-UCSF Institute of Genomic Immunology and Bay Area biomedical science with @sanfranmag .

5 Questions With Dr. Alexander Marson

As director of the recently opened Gladstone-UCSF Institute of Genomic Immunology, Dr. Alexander Marson is working hard to discover and implement new ways to combat diseases through tailored i…

sanfran.com

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Marson Lab

@MarsonLab

2 months

Our lab is searching for new technicians interested in working on CRISPR genetic engineering in human T cells applied to T cell genetic networks or HIV-T cell interactions. Great opportunity for a couple of years of research experience before MD or PhD!

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Marson Lab

@MarsonLab

3 years

A wide-reaching conversation on the state of biology and biotech w/ some speculation on where we're headed. Thanks to @SpotlightThera co-founder @pdhsu from @igisci and @JorgeCondeBio from @a16z .

Jorge Conde

@JorgeCondeBio

3 years

Patrick Hsu @pdhsu + Alex Marson @MarsonLab join me on the @a16z Bio Eats World podcast! We discuss the state of biology today, discovery ➡️ translation in academia vs startups, and how cycles of innovation in bio are accelerating + compounding 🧬 🚀

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Marson Lab

@MarsonLab

9 months

Congratulations to lab postdoc Ronghui Zhu (co-mentored w/ @jkpritch ) on his @DamonRunyon fellowship!

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Marson Lab

@MarsonLab

3 years

Excited for our Genomic Immunology Symposium tomorrow!

Gladstone Institutes

@GladstoneInst

3 years

🔬 SCIENCE TREND: Hear Keynote Carl June @carlhjune from @parkerici and @Penn at 1pm PST (Nov. 3) at the Gladstone- @UCSF Institute of Genomic Immunology Symposium, "Innovators of Genomic Immunology." Complimentary registration. Hosted by @MarsonLab

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Marson Lab

@MarsonLab

2 months

Proud to play a small role in this great work! And excited to welcome Jun Yun as a Marson Lab postdoc later this year...

Britt Adamson

@bsadamson

2 months

Excited to share with you our manuscript describing the endogenous protein La as a mediator of prime editing and the development of our PE7 editor, which can improve prime editing. For more, please check out

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Marson Lab

@MarsonLab

2 months

Awesome highlight of our incredible technician Rama Dajani who has been instrumental for multiple really major projects in the lab! Can't wait to see what she does in grad school.

Gladstone Institutes

@GladstoneInst

2 months

In high school, Rama Dajani, was able to visit Gladstone thanks to a biotechnology program and an influential teacher. Today, Dajani is a research associate in Alex Marson’s lab ( @MarsonLab )

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Marson Lab

@MarsonLab

3 years

We find that IL2RA regulators form highly interconnected gene networks enriched for immune genes including enhancers and genes associated with immune-mediated diseases such as MS. Lots to dig into here - let us know what you think!

Systematic discovery and perturbation of regulatory genes in human T cells reveals the architecture...

Complex gene regulatory networks ensure that important genes are expressed at precise levels. When gene expression is sufficiently perturbed it can lead to disease. To understand how gene expression...

www.biorxiv.org

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Marson Lab

@MarsonLab

5 years

Marson Lab supports Wear White Day for a Future #Immune2Cancer @CancerResearch

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Marson Lab

@MarsonLab

5 years

Congrats, Dr. Simeonov @iamdimitre ! Dimitre was the Marson lab's first graduate student. He made big science contributions and helped build the lab's collaborative culture.

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Marson Lab

@MarsonLab

5 years

Honored to present on the future of gene-modified cell therapies. Thank you Wall Street Journal Future of Everything Festival. #WSJFuture

Angelique Olmo

@AngeliqueOlmo

5 years

Alexander Marson tells us the next medicines are living cells. #WSJFuture

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Marson Lab

@MarsonLab

3 years

Proud of my amazing sister, Eve Marson. 20 years after 9/11, the path we took from that Turning Point could hardly be more relevant. Looking forward to reflecting and learning from this timely Netflix series.

Turning Point: 9/11 and the War on Terror | Official Trailer | Netflix

Modern history can be divided into two time frames: before 9/11 and after 9/11. This five-part docuseries from director Brian Knappenberger is a cohesive chr...

www.youtube.com

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Marson Lab

@MarsonLab

6 years

A truly great present. Proud to sport this new look.

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Marson Lab

@MarsonLab

25 days

I’m excited to be a panelist during @CancerResrch & @parkerici ’s public meeting in Washington, DC “Unlocking Complex Cell-based Gene Therapies” on Monday, May 6 from 10:00AM – 2:15PM ET. Join us in person or virtually by registering here: 📷

Unlocking Complex Cell-based Gene Therapies - Friends of Cancer Research

Monday, May 6th, 2024 10:00AM – 2:15PM ET The Ritz Carlton 1150 22nd St NW Washington, DC 20037 Watch the Full Meeting Friends of Cancer Research (Friends) and the Parker Institute for Cancer...

friendsofcancerresearch.org

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Marson Lab

@MarsonLab

5 years

Beautiful new review on the evolving landscape of CAR T Cell design from Kole Roybal and colleagues:

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Marson Lab

@MarsonLab

2 years

Systematic testing of HIV regulators in human T cells led by amazing MSTP student, @Hiattsmejoe . The result of wonderful (and ongoing) collaborations on host-pathogen interactions with @HultquistLab and @KroganLab .

Krogan Lab

@KroganLab

2 years

In our new paper, we knocked-out 426 proteins that physically interact with #HIV using #CRISPR in primary human CD4+ T cells. Our systematic approach reveals host-pathogen protein interactions to be an enriched source of functional host factors.

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Marson Lab

@MarsonLab

3 years

Come work with us 👇

Stacie Dodgson, PhD

@StacieDodgson

3 years

The @MarsonLab has a position open for a research associate to work on gene regulatory network mapping in human immune cells. Check out this related preprint: & apply here:

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Marson Lab

@MarsonLab

4 years

60 Minutes this coming Sunday: I'll be talking COVID-19 antibody testing with @pdhsu . #COVID19 #SARSCoV2 @ucsf @czbiohub @GladstoneInst @igisci

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Marson Lab

@MarsonLab

2 months

Profoundly honored to be included on this panel. Looking forward to the event with some of my heroes and friends. #AACR2024 #Immunotherapy

AACR

@AACR

2 months

Cancer Immunotherapy: Where Do We Go From Here? @AACRPres Philip Greenberg will moderate this #AACR24 Presidential Select Symposium, featuring James Allison, Nir Hacohen, Alexander Marson, and Andrea Schietinger. @JimAllisonPhD @MarsonLab @SchietingerLab

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Marson Lab

@MarsonLab

4 years

See also complementary findings from Ye Zheng and @HargreavesLab @salkinstitute . They present genome-wide screen in Tregs and identify ncBAF and SAGA complexes to be important regulators of Foxp3 expression and Treg function.

A genome-wide CRISPR screen reveals a role for the BRD9-containing non-canonical BAF complex in...

Regulatory T cells (Tregs) play a pivotal role in suppressing auto-reactive T cells and maintaining immune homeostasis. Treg development and function are dependent on the transcription factor Foxp3....

www.biorxiv.org

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Marson Lab

@MarsonLab

2 years

Wrapping up an incredible summer full of stellar interns in the Marson lab! Thanks to @GladstoneInst #PUMAS , @EmCollective #FirstGen , @SEP_UCSF for their partnerships to bring in talented students.

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Marson Lab

@MarsonLab

1 month

This is an amazing look at what I’ve always considered the art of science.

Michael Fischbach

@mfgrp

1 month

How to pick a problem. Today in @CellCellPress . 1/53

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Marson Lab

@MarsonLab

6 years

Excited about the potential of SLICE— our new gene target discovery platform in human immune cells. A wonderful collaboration with Alan Ashwoth and PICI led by Eric Shifrut and Julia Carnevale.

Stacie Dodgson, PhD

@StacieDodgson

6 years

Cool new work from @MarsonLab @UCSF in @CellCellPress combining genome-wide CRISPR screens in primary human T cells with Perturb-seq to ID genes involved in #tumor cell killing #immunotherapy

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Marson Lab

@MarsonLab

3 months

We're hiring for a joint technician at @GladstoneInst Genomic Immunology with our lab and @Satpathology to become an expert in genomic technologies like ATAC & ChIP. Great opportunity for a new grad or someone with a couple of years postgrad experience!

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Marson Lab

@MarsonLab

5 years

Fun night out at @CASNightLife talking about all things #CRISPR . Thank you @immunox ! Prof and a Pint 🍻

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Marson Lab

@MarsonLab

2 years

New insights into how to help T cells resist exhaustion. Proud to be part of this collaboration!

Ansu Satpathy

@Satpathology

2 years

Delighted to share our story out in @Cancer_Cell ! Incredible amount of work led by Julia Belk and Winnie Yao, and wonderful collaborations with many close colleagues @SantoshVardhana @jccarnevale @MarsonLab @MackallLab

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Marson Lab

@MarsonLab

5 years

Come work with us! We are hiring 4 Research Associates in the Marson Lab. Find out more about the available positions and how to apply at the link below.

Innovative Genomics Institute

@igisci

5 years

We're #hiring ***6*** new research assistants in Berkeley and San Francisco! 🌉 We're looking for applicants who are excited about advancing novel tech for in #CRISPR therapeutics! You should have a BA/MS, but extensive experience is *not* required.

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Marson Lab

@MarsonLab

5 years

Now it’s even faster to design & test new DNA programs ("molecular apps") that we can install into the genetic code of human immune cells to hack new treatments for cancer and other diseases. Congrats to Theo Roth & collaborators: #CRISPR #CellEngineering

Rapid discovery of synthetic DNA sequences to rewrite endogenous T cell circuits

Genetically-engineered immune cell therapies have been in development for decades[1][1]–[3][2] and recently have proven effective to treat some types of cancer[4][3]. CRISPR-based genome editing...

www.biorxiv.org

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