Lowe Lab @LoweLabMSKCC Twitter profile

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Lowe Lab

@LoweLabMSKCC

2 years

Out in @Nature today, we report that #p53 loss unleashes an ordered & selective pattern of cancer #GenomeEvolution : . 1/n

Ordered and deterministic cancer genome evolution after p53 loss

Nature - Malignant evolution enabled by p53 inactivation in mice proceeds through an ordered and predictable pattern of Trp53 loss of heterozygosity, accumulation of deletions, genome doubling and...

www.nature.com

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@LoweLabMSKCC

3 years

Out in @Nature today, our latest work shows how tissue injury and Kras mutation cooperate to induce an epigenetic program that initiates pancreatic tumorigenesis. (1/3)

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Lowe Lab

@LoweLabMSKCC

4 years

Out in @Nature today, our latest work provides a proof of concept for the utility of #CART cells as #senolytics . This study was an exciting collaboration with the #SadelainLab ... (1/3)

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Lowe Lab

@LoweLabMSKCC

2 years

My 2nd Spanish postdoc @AmaiaLujambio is an inspiring scientist & friend. With @KrizhanovskyLab , she revealed key links b/w senescence & tumorigenesis. She was a point person in our transition @CSHL ➡️ @MSKCancerCenter . So proud of her success at @IcahnMountSinai ! –SWL #LoweLab25

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Lowe Lab

@LoweLabMSKCC

2 years

To mark 25 years (!!) since my first faculty appointment, I will be highlighting some of the fantastic Lowe lab trainees over the years, from its origins @CSHL to evolution @MSKCancerCenter . These are the people that made the Lowe lab what it is today. Stay tuned! –SWL #LoweLab25

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Lowe Lab

@LoweLabMSKCC

2 years

New Preprint! Led by #DynamicDuo @BarrigaFM & @KTsanov , this study set out to understand how somatic copy number alterations (CNAs) promote cancer. CNAs are prevalent across cancer types & correlate w/ clinical outcomes but remain difficult to study. 1/n

Chromosome 9p21.3 Coordinates Cell Intrinsic and Extrinsic Tumor Suppression

Somatic chromosomal deletions are prevalent in cancer, yet their functional contributions remain ill-defined. Among the most prominent of these events are deletions of chromosome 9p21.3, which...

www.biorxiv.org

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Lowe Lab

@LoweLabMSKCC

2 years

My 2nd postdoc Marisol Soengas @msmelanoma helped establish a culture of drive & excellence in the lab @CSHL . After a successful tenure @UMich , she returned home to @CNIOStopCancer , where she is Head/Melanoma Group & VP @ASEICAnews . Check out her inspiring work! –SWL #LoweLab25

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Lowe Lab

@LoweLabMSKCC

5 years

Congratulations to Dr. Lowe for his recent election to the @theNAMedicine !

Memorial Sloan Kettering Cancer Center

@MSKCancerCenter

5 years

Join us as we congratulate our own Dr. Scott W. Lowe, who was just elected to the @theNAMedicine ! Want to know more about Dr. Lowe's award-winning research? Follow us behind the scenes in his lab. @LoweLabMSKCC #NAMmtg

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Lowe Lab

@LoweLabMSKCC

8 months

What an incredible Reunion! It was wonderful to see all former lab members who traveled to NYC from all over the world & to experience the joy that we all shared in getting together. THANK YOU & stay in touch! #LoweLab25

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Lowe Lab

@LoweLabMSKCC

2 years

Out in @PNASNews today, we report new flexible mouse models of #OvarianCancer , and use them to gain insights into the role of #Senescence in chemo- & immunotherapy responses: .

Senescence induction dictates response to chemo- and immunotherapy in preclinical models of ovarian...

High-grade serous ovarian carcinoma (HGSOC) is a cancer with dismal prognosis due to the limited effectiveness of existing chemo- and immunotherapi...

www.pnas.org

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Lowe Lab

@LoweLabMSKCC

2 years

Congratulations to postdoc @KTsanov on receiving the @NIH K99/R00 Pathway to Independence Award!! 👏🎉🚀

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Lowe Lab

@LoweLabMSKCC

2 years

Now out in @NatureCancer , an updated version of our study developing the #MACHETE strategy for modeling large genomic deletions and using it to uncover a key role for type I #IFN deletions in tumor #ImmuneEvasion & #Metastasis : (1/3)

MACHETE identifies interferon-encompassing chromosome 9p21.3 deletions as mediators of immune...

Nature Cancer - Barriga et al. develop MACHETE, a genome engineering strategy enabling the flexible modeling of megabase-sized deletions and show that the concomitant loss of the interferon cluster...

www.nature.com

Lowe Lab

@LoweLabMSKCC

2 years

New Preprint! Led by #DynamicDuo @BarrigaFM & @KTsanov , this study set out to understand how somatic copy number alterations (CNAs) promote cancer. CNAs are prevalent across cancer types & correlate w/ clinical outcomes but remain difficult to study. 1/n

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Lowe Lab

@LoweLabMSKCC

3 years

First major Lowe lab event in 18 months. It was great to see everyone together and having fun. We are back!

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Lowe Lab

@LoweLabMSKCC

4 years

Excited to share our new study @CellCellPress showing that #senescence -inducing drugs sensitize #PancreaticCancer to #chemotherapy and #immunotherapy . Thanks to co-first authors @marcus_ruscetti , @johnpmorrisiv & @r_mezzadra , the rest of the lab & our collaborators!

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Lowe Lab

@LoweLabMSKCC

1 year

Now out in @ScienceMagazine , the final version of our fantastic collaboration with @dana_peer led by @CassBurdziak & @DirenaAC , uncovering how epigenetic plasticity cooperates with cell-cell interactions to drive pancreatic cancer: .

Epigenetic plasticity cooperates with cell-cell interactions to direct pancreatic tumorigenesis

Single-cell analysis reveals that enhanced epigenetic plasticity drives pro-neoplastic cross-talk in early pancreatic cancer.

www.science.org

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Lowe Lab

@LoweLabMSKCC

5 years

The Lowe Lab has joined Twitter! Follow us for updates on science & lab happenings. We’re learning about hashtags and such… @sloan_kettering @HHMINEWS #FirstTweet

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Lowe Lab

@LoweLabMSKCC

2 years

@DirenaAC came to my lab from @msmelanoma , and her enthusiasm, collegiality & dedication led the lab for many years. She visited NYC yesterday to receive a @BlavatnikAwards for her amazing work. Check out her new lab @IRBBarcelona ! –SWL #LoweLab25

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Lowe Lab

@LoweLabMSKCC

4 years

Farewell & Congratulations to postdoc @JosefLeibold on his faculty position at @uni_tue @uktuebingen ! The Leibold Lab opens next month and is hiring.

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Lowe Lab

@LoweLabMSKCC

2 years

Congratulations to the newest Lowe lab graduate -- Corina Amor, MD, PhD!! @GSKGradSchool

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Lowe Lab

@LoweLabMSKCC

2 years

I met Luke Dow @LorneCancer in 2007 & rest is history. He was a lab leader @CSHL & key in our move to @MSKCancerCenter . His APC paper is among my all-time favorites & spearheaded him to a remarkable career @WeillCornell . Check out @dow_lab ! –SWL #LoweLab25

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Lowe Lab

@LoweLabMSKCC

9 months

Congratulations to postdoc @r_mezzadra on receiving the @NIH K99/R00 Pathway to Independence Award!! 👏🕺🚀

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Lowe Lab

@LoweLabMSKCC

2 years

At @MSKCancerCenter today for a seminar, @Johannes_Zuber was one of the prominent “German MDs” to elevate science in the Lowe lab. Now a tenured group leader @IMPvienna , Hannes’ rigor and creativity produced tools & concepts that still guide our work. –SWL #LoweLab25

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Lowe Lab

@LoweLabMSKCC

2 years

Now out in @CD_AACR , an updated version of our story on how #senescence rewires #microenvironment sensing to promote #immune surveillance. Congratulations to 1st author @An_Hsuan , co-corresponding author @DirenaAC & everyone else who contributed! (1/3)

Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity

Tumor cells triggered to senesce alter how they send and receive microenvironmental signals, leading to tissue remodeling, immune cell recruitment, hypersensitization to environmental IFNγ, and...

aacrjournals.org

Lowe Lab

@LoweLabMSKCC

2 years

New pre-print! Today we report that #Senescence remodels the #CellSurface to enhance sensing of environmental factors, as exemplified by #IFNgamma . Thus, senescence boosts the cell's ability to both 📤 & 📥signals.

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Lowe Lab

@LoweLabMSKCC

2 years

New pre-print! In a wonderful collaboration with @dana_peer , we report that #EpigeneticPlasticity cooperates with emergent #CellCellInteractions to drive a neoplasia-specific tissue remodeling program in the pancreas.

Epigenetic plasticity cooperates with emergent cell-cell interactions to drive neoplastic tissue...

The response to tumor-initiating inflammatory and genetic insults can vary amongst morphologically indistinguishable cells, suggesting yet uncharacterized roles for epigenetic plasticity during early...

www.biorxiv.org

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Lowe Lab

@LoweLabMSKCC

2 years

Congratulations on a fabulous thesis defense, DR. Stella Paffenholz @StellaPaff !! 👏🍾🎉 @GSKGradSchool @MSKEducation

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Lowe Lab

@LoweLabMSKCC

2 years

New pre-print! Today we report that #Senescence remodels the #CellSurface to enhance sensing of environmental factors, as exemplified by #IFNgamma . Thus, senescence boosts the cell's ability to both 📤 & 📥signals.

Senescence rewires microenvironment sensing to facilitate anti-tumor immunity

Cellular senescence involves a stable cell cycle arrest coupled to a secretory program that, in some instances, stimulates the immune clearance of senescent cells. Using an immune competent tumor...

www.biorxiv.org

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Lowe Lab

@LoweLabMSKCC

4 years

Happy to share our latest work @CD_AACR developing fast & flexible method to model #ProstateCancer that led us to uncover an actionable role for #WNT signaling in driving #metastasis in this cancer. (1/2)

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Lowe Lab

@LoweLabMSKCC

2 years

Starting 2022 strong! Congratulations on an outstanding thesis defense, Dr. Sean Chen! 🙌🎉🎓 @GSKGradSchool @MSKEducation

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Lowe Lab

@LoweLabMSKCC

4 years

Congratulations to postdoc @johnpmorrisiv on his faculty position at @UNC_SOM @UNC_Lineberger ! The Morris Lab opens in October and is hiring.

John P. Morris IV, PhD | Pharmacology

Research Interests Oncogene and tumor suppressor networks Malignant specification and lineage plasticity Evolution of cancer epigenetic and genomic heterogeneity Research Synopsis Tumorigenesis...

www.med.unc.edu

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Lowe Lab

@LoweLabMSKCC

3 years

Congratulations to postdoc @DirenaAC on her faculty position @IRBBarcelona ! The Alonso-Curbelo Lab opens soon and is hiring.

Direna Alonso-Curbelo

@DirenaAC

3 years

Hi twitter world, I have news: I am very happy to announce that I will be joining the @IRBBarcelona this fall as group leader! The lab will study the interplay between #genetics , #inflammation and #cell_identity programs in #cancer to devise strategies for early #interception .

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@LoweLabMSKCC

2 years

While striving to do great research, the Lowe lab believes that science should be fun. @CSHL the lab sponsored parties during the cancer-related @cshlmeetings that led to new friendships, interactions & new collaborations – not to mention some sleepy participants. #LoweLab25 1/3

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@LoweLabMSKCC

3 years

Excited to present to you Dr. Grace Li! Congratulations on a wonderful thesis defense! @WeillCornellGS @MSKEducation

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Lowe Lab

@LoweLabMSKCC

4 years

Congratulations @EvangeliaLoizou !

Weill Cornell GSMS

@WeillCornellGS

4 years

Congratulations to Evangelia Loizou from Dr. Scott Lowe's lab for successfully defending her Ph.D. dissertation entitled "In vivo Modelling of Myeloid Hematological Malignancies with Complex Karyotypes."

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@LoweLabMSKCC

4 years

Congratulations to former student Chi-Chao Chen, whose paper was just published @Cancer_Cell . The study was a fantastic collaboration with @Lingbo_Zhang @CSHL and identifies the #vitamin B6 pathway as important for #leukemia maintenance.

Vitamin B6 Addiction in Acute Myeloid Leukemia

In a CRISPR/Cas9 functional screen targeting metabolic enzymes, Chen et al. identify PDXK, which produces pyridoxal phosphate (PLP) from vitamin B6, as an AML dependency. PLP-dependent enzymes ODC1...

www.cell.com

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@LoweLabMSKCC

2 years

Out now in @PNASNews , we report a new preclinical in vivo platform for assessment of cancer drug targets: .

A preclinical platform for assessing antitumor effects and systemic toxicities of cancer drug...

Anticancer drug development campaigns often fail due to an incomplete understanding of the therapeutic index differentiating the efficacy of the ag...

www.pnas.org

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@LoweLabMSKCC

3 years

Big congratulations to postdoc @DirenaAC (soon to be faculty @IRBBarcelona ) on winning the 2021 Blavatnik Regional Award in the Life Sciences!

Blavatnik Awards

@BlavatnikAwards

3 years

Announcing the 2021 Blavatnik Regional Awards Life Science Honorees 🏅 🏅 🏅 #NPAW2021 @DirenaAC @sloan_kettering @LoweLabMSKCC @MSKEducation @CpcrMsk @LukaMesin @victora_lab @RockefellerUniv @jiang_wenyan @ColumbiaScience @Columbia @nationalpostdoc

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@LoweLabMSKCC

3 years

A great night celebrating the end of summer (+ a few birthdays) last week. Thanks to #MSKFunFund @MSKEducation @UshmaNeill !

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Lowe Lab

@LoweLabMSKCC

2 years

I am particularly proud of former trainees #MikeHemann & #FranciscoS ánchezRivera @HHMINEWS , now faculty at my alma matter @MITBiology @KochInstitute . Both were ‘go-to’s’ and cultural mainstays, contributing broadly to the lab’s research & the ‘esprit de corps.’ –SWL #LoweLab25

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Lowe Lab

@LoweLabMSKCC

2 years

Awesome MD/PhD student Prem Premsrirut @CSHL founded @Mirimus based on her thesis research. As CEO, she oversaw the dev't of award-winning & cost-effective #COVID19 test used across the region . So proud of her leadership & accomplishments! –SWL #LoweLab25

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Lowe Lab

@LoweLabMSKCC

2 years

Pre-print Alert! Today we report the development of rapid & flexible platform for #GastricCancer mouse modeling and use it to produce a suite of models w/ different #Genotypes & #HostBackgrounds , uncovering genotype-specific features of #MetastaticDisease .

Somatic mouse models of gastric cancer reveal genotype-specific features of metastatic disease

Metastatic gastric carcinoma is a highly lethal cancer that responds poorly to conventional and molecularly targeted therapies. Despite its clinical relevance, the mechanisms underlying the behavior...

www.biorxiv.org

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Lowe Lab

@LoweLabMSKCC

2 years

Brightening up a rainy day with a fun lab lunch! #NYCRestaurantWeek #HappyFriday

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Lowe Lab

@LoweLabMSKCC

3 years

Ready for tonight's virtual holiday party, thanks to our amazing lab management (and a bunch of Secret Santas)!

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Lowe Lab

@LoweLabMSKCC

3 years

Congratulations to postdoc @fjsanchezrivera on his faculty position at @kochinstitute @MITBiology ! The Sánchez-Rivera Lab opens in Spring 2022 and will soon be hiring.

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Lowe Lab

@LoweLabMSKCC

1 year

Happy Holidays to all!

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Lowe Lab

@LoweLabMSKCC

2 years

After a 3-year hiatus, the Lowe Lab Retreat was back on last week, incl. team-based science idea competition, lab-related discussions & Halloween costume party. As always, that entailed a lot of fun & the making of great memories!

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Lowe Lab

@LoweLabMSKCC

2 years

Out now in @NatureBiotech , a powerful toolbox for using #BaseEditing to functionally interrogate genetic variants in cancer and beyond. Terrific collaboration with @dow_lab :

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Lowe Lab

@LoweLabMSKCC

4 years

Official farewell to postdoc @johnpmorrisiv , who launches the Morris Lab at @UNC_SOM @UNC_Lineberger tomorrow!

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Lowe Lab

@LoweLabMSKCC

8 months

Early @CSHL postdoc Elisa de Stanchina made a big splash studying the ARF tumor suppressor. She now runs the world’s best preclinical modeling core @MSKCancerCenter , where she continues to work with our lab on a daily basis. -SWL #LoweLab25

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Lowe Lab

@LoweLabMSKCC

2 years

Farewell to our latest graduate, Dr. @StellaPaff , and best of luck for her next endeavor @NextechInvest ! #LoweLab25

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Lowe Lab

@LoweLabMSKCC

2 years

Thanks to @IanDemsky @MSKCancerCenter for this fantastic editorial on our #MACHETE #9p21 study!

New MACHETE Technique Slices Into Cancer Genome To Study Copy Number

Learn why MSK researchers developed MACHETE, a new CRISPR-based technique to study large-scale genetic deletions efficiently in laboratory models.

www.mskcc.org

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Lowe Lab

@LoweLabMSKCC

2 years

Three graduates in one year! Congratulations to Dr. Amor @corina_amor_MD , Dr. Li @Xiang_Grace_Li & Dr. Chen @an_hsuan !!! @GSKGradSchool @WeillCornellGS @MSKEducation 🎓🎓🎓👏👏👏🍾🍾🍾

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Lowe Lab

@LoweLabMSKCC

9 months

T-10 days to the '25 Years of Lowe Lab' Reunion! Looking forward to welcoming back 80+ alumni for two days of science, memories, and catching up. Will continue to highlight lab alums over the coming days. #LoweLab25

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Lowe Lab

@LoweLabMSKCC

1 year

Congratulations to postdoc Pancho Barriga @barrigafm on being awarded an @ERC_Research Starting Grant AND on accepting a faculty position @VHIO ! The Barriga lab opens next month & is hiring. 🍾🎉🚀

Pancho Barriga

@barrigafm

1 year

I’m delighted to announce two major developments for my career: First, I will be joining the amazing @VHIO as a Group Leader! Second, I have been awarded an #ERCStG (MACHETE!) to start my lab @ERC_Research . I look forward to join the vibrant Barcelona research community!

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Lowe Lab

@LoweLabMSKCC

2 years

Clemens Schmitt was my 1st "German MD" @CSHL & inspired 15 others to join. He had 4(!) first-author papers, incl. the 1st to show real senescence biology in vivo: . He continues to be a thought leader @MDC_Berlin @ChariteBerlin @BSIO_Berlin . –SWL #LoweLab25

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Lowe Lab

@LoweLabMSKCC

9 months

Several Lowe lab #powercouples have had major impact on its science & culture. 1st Masako & Masashi Narita @CSHL raised the bar for experimental precision and established why senescent cells stably arrest. Check out their enormously successful @narita_lab @CR_UK ! -SWL #LoweLab25

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Lowe Lab

@LoweLabMSKCC

2 years

Former postdoc Ross Dickins @CSHL developed a powerful gene regulation system that continues to produce impactful science. Back down under, @DickinsLab @ACBDresearch @MonashUni studies leukemia & immune checkpoints. He just visited us and presented amazing work! –SWL #LoweLab25

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Lowe Lab

@LoweLabMSKCC

2 years

Congratulations to @ScottMillmanMD on receiving the @NIH K08 Mentored Clinical Scientist Research Career Development Award!! 👏🎉🚀

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Lowe Lab

@LoweLabMSKCC

2 years

One of the highlights for the Lowe lab are the @CSHLMeetings , where many of us have presented our work. These meetings have also served as lab reunions - here the Lowe lab family ca 2010. See you at Mechanisms & Models this week! #LoweLab25

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Lowe Lab

@LoweLabMSKCC

4 years

Lowe Lab Happy Hour today. Turning #SocialDistancing into #DistantSocializing . Stay safe, everyone!

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Lowe Lab

@LoweLabMSKCC

2 years

Proud of our amazing graduate students, ALL of whom were recently awarded competitive fellowships 🚀🚀🚀👇👇👇

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Lowe Lab

@LoweLabMSKCC

2 years

Pancho @BarrigaFM is an innovative molecular biologist & mouse modeler who is currently looking for faculty positions. He will be a great colleague & collaborator at any institute lucky enough to get him! –SWL 9/9

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Lowe Lab

@LoweLabMSKCC

1 year

The Lowe lab (+ alums & friends!) is at #AACR23 ! Looking forward to another day of great science and socializing.

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Lowe Lab

@LoweLabMSKCC

4 years

Congratulations to postdoc @Marcus_Ruscetti on accepting a faculty position at @UMassMedical ! The Ruscetti Lab opens September 1 and is already hiring.

Marcus Ruscetti, Ph.D.

Our laboratory is studying how tumors, and in particular prostate and pancreatic cancers, escape immune surveillance during disease progression, and trying to restore tumor suppressive pathways lost...

www.umassmed.edu

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Lowe Lab

@LoweLabMSKCC

1 year

Now out in @eLife , the final version of our manuscript that uncovers mutation of the chromatin modifier #MLL3 as a new way to disrupt the major tumor-suppressor gene #CDKN2A in liver cancer: .

MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer

Epigenetic regulator MLL3 is mutated and lost in human hepatocellular carcinoma due to its ability to activate a well-defined tumor suppressor and cell death in transformed cells.

elifesciences.org

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Lowe Lab

@LoweLabMSKCC

5 years

Another year, another Lowe Lab retreat! The lab headed to the Jersey Shore for some fun, sharing of scientific ideas, and, being so close to Halloween, a costume contest!

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Lowe Lab

@LoweLabMSKCC

1 year

Congratulations to postdoc @TimourBaslan on being awarded the 2023 Tri-Institutional Breakout Prize for Junior Investigators AND on his faculty position at @PennCancer ! The Baslan Lab opens in September & is hiring. 👏🎉🚀

Memorial Sloan Kettering Cancer Center

@MSKCancerCenter

1 year

Congratulations to @TimourBaslan , the O'Neil Charitable Trust Fellow and a postdoc in the @LoweLabMSKCC , on receiving this year's Tri-Institutional Breakout Prize for Junior Investigators for his research on cancer genome evolution.

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Lowe Lab

@LoweLabMSKCC

9 months

Join us at @MSKCancerCenter for this exciting meeting Oct 29 - Nov 1, organized with @Nature @NatureCancer @NatureRevCancer #TumourLandscape2023 . Abstract Deadline: Aug 28. More info👇

Nature Conferences

@NatureConf

10 months

Deadline: Aug 28 Submit at: Topics: #MappingTumours #Tumors #microenvironment #SystemicEnvironment #TherapeuticTargeting #TherapyResistance and more @MSKCancerCenter @NatureCancer @NatureRevCancer #TumourLandscape23

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Lowe Lab

@LoweLabMSKCC

2 years

Former student Katie McJunkin was a dominating force in our #RNAi efforts with Greg Hannon ca. 2010s. She had a great postdoc with @RNAmbros @UMassChan and now runs her own @mcjunkin_lab @NIH studying microRNA regulation. Katie is scary smart & tons of fun! –SWL #LoweLab25

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Lowe Lab

@LoweLabMSKCC

2 years

We look forward to welcoming @MaraShermanLab to the Cancer Biology & Genetics Program @MSKCancerCenter in a few months!

Mara Sherman Lab

@MaraShermanLab

2 years

Shermlab goes east! A new chapter begins @MSKCancerCenter @CpcrMsk in Jan 2023. Forever grateful to my amazing OHSU mentors and colleagues, and excited for the scientific interactions, NYC adventures, and #feiginworthy bagels ahead! 1/2

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Lowe Lab

@LoweLabMSKCC

7 months

Thanks to @TheMarkFdn for their outstanding support! Excited to dig deep into #senescence biology to harness its potential for improving #immunooncology outcomes, w/ fantastic team #JulioGarciaAguillar @dana_peer @DrPaulRomesser @Michel_Sadelain @SchietingerLab .

The Mark Foundation for Cancer Research

@TheMarkFdn

7 months

Congratulations Endeavor team at Memorial Sloan Kettering: Scott Lowe, Julio Garcia-Aguilar, Dana Pe’er, Paul Romesser, Michel Sadelain, Andrea Schietinger @MSKCancerCenter @LoweLabMSKCC @DrGarciaAguilar @DrPaulRomesser @Michel_Sadelain

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Lowe Lab

@LoweLabMSKCC

3 years

Excited to co-lead the #T -SMAC team shortlisted for the #CancerGrandChallenges awards @CancerGrand @theNCI @CR_UK . We aim to tackle the challenge & opportunity of targeting #senescence for #cancer therapy. (1/3)

Cancer Grand Challenges

@CancerGrand

3 years

BREAKING NEWS: today we announce 11 teams selected to compete for our awards! Winners receive up to £20m each and the freedom to unleash their scientific creativity, conducting research that transcends geography and discipline - #CancerGrandChallenges

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Lowe Lab

@LoweLabMSKCC

1 year

Congratulations to grad student @Issy_DelPriore on successfully passing her qualifying exam! 👏🎉🥳 #PhDCandidate

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Lowe Lab

@LoweLabMSKCC

2 years

Congratulations to postdoc @ZedaZhang on being awarded a @DamonRunyon fellowship!

Damon Runyon Cancer Research Foundation

@DamonRunyon

2 years

We’re thrilled to announce our newest cohort of Damon Runyon Fellows! This Fellowship provides promising young scientists with funding to work on innovative projects. We can't wait to see how our Fellows will contribute to cancer research! Learn more:

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Lowe Lab

@LoweLabMSKCC

4 years

Congratulations, Corina!

GSK Graduate School

@GSKGradSchool

4 years

Congratulations to #GSK student, Corina Armor Vegas, MD, who has been awarded the NCI Predoctoral to Postdoctoral Fellow Transition Fellowship. Corina is a 4th year PhD candidate in the lab of Dr. Scott Lowe. @LoweLabMSKCC

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Lowe Lab

@LoweLabMSKCC

2 years

Lowe lab has always embraced principles of collaboration & mutual support – over the years its camaraderie has created many ties that bind. Here, former student Katie McJunkin & postdoc Luke Dow collaborate during lab party in Summer 2011. @mcjunkin_lab @dow_lab –SWL #LoweLab25

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Lowe Lab

@LoweLabMSKCC

2 years

Between @CSHL & @MSKCancerCenter , the lab has had 20 graduate students (and counting) over the years... (1/3)

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Lowe Lab

@LoweLabMSKCC

3 years

Fantastic, Direna!

Direna Alonso-Curbelo

@DirenaAC

3 years

From public education to public transport! 🙈

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Lowe Lab

@LoweLabMSKCC

2 years

New pre-print! In our latest study, we show that #MLL3 acts as a tumor suppressor in #LiverCancer by co-activating the #CDKN2A locus. Hence, MLL3 mutation/loss is a new mechanism for disrupting CDKN2A activity during cancer development. .

MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer

Mutations in genes encoding components of chromatin modifying and remodeling complexes are among the most frequently observed somatic events in human cancers. For example, missense and nonsense...

www.biorxiv.org

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Lowe Lab

@LoweLabMSKCC

1 year

Congratulations to postdoc @TimourBaslan on being recognized as an #AACR2023 NextGen Star! Don’t miss his talk on genome evolution following p53 loss today 👇

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Lowe Lab

@LoweLabMSKCC

8 months

Lars Zender single-handedly initiated carcinoma research in the Lowe lab. He has been enormously successful as scientist & leader, winning a Leibniz Prize & serving as Director of Med Oncology @uni_tue and leader of a German Center of Excellence @CoE_iFIT . -SWL #LoweLab25 (1/2)

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Lowe Lab

@LoweLabMSKCC

3 years

Congratulations to grad student @corina_amor_MD on her independent @CSHL_Fellows position! The Amor lab will open in January 2022 and is hiring. @CSHL @GSKGradSchool

Corina Amor MD, PhD

@corina_amor_MD

3 years

I’m very excited to share that I’ll be starting my own research group @CSHL in January 2022 as a @CSHL_Fellows .

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Lowe Lab

@LoweLabMSKCC

2 years

Congratulations to #CarolineBroderick on receiving the @NIH F31 Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship! 👏🎉🍾

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Lowe Lab

@LoweLabMSKCC

2 years

Many of these parties were at Scott’s house and produced good times and great stories – the ‘boat incident’ is now @CSHL lore. And the parties featured the Lowe lab band, which was so successful that Greg Hannon @CRUK_CI had to copy (and improved upon) the concept. #LoweLab25 2/3

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Lowe Lab

@LoweLabMSKCC

2 years

The Lowe lab’s last party @CSHL was its ‘Woodstock,’ with multiple bands & events. And Scott made a guest appearance with Greg. BTW, Scott is co-organizer of the Cancer Biology meeting @cshlmeetings in October 2023. Great science and fun! #LoweLab25 3/3

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Lowe Lab

@LoweLabMSKCC

8 months

Lab mainstay Zhen Zhao ( @sparkling_pm ) received great mentorship from postdocs @LabWendel & @Johannes_Zuber as a student @CSHL and then did a postdoc in our lab @MSKCancerCenter . She became a pathologist and has a new position back at CSHL! -SWL #LoweLab25

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Lowe Lab

@LoweLabMSKCC

3 years

Congratulations to @ZedaZhang on being awarded a Postdoctoral Fellowship in Aging Research by @AFARorg & the Glenn Foundation for Medical Research!

Memorial Sloan Kettering Cancer Center

@MSKCancerCenter

3 years

SKI’s @ZedaZhang of @LoweLabMSKCC has received the Postdoctoral Fellowship in Aging Research by @AFARorg & the Glenn Foundation for Medical Research! Please join us in congratulating Dr. Zhang. For more on this and other staff accomplishments, click here.

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Lowe Lab

@LoweLabMSKCC

10 months

Congratulations to postdoc @vBarthet on being awarded a @CancerResearch fellowship! Valentin will investigate how oncogene-induced #senescence impacts the #immune response during #aging . 👏🎉🥳

Valentin J. A. Barthet, PhD

Dr. Valentin J. A. Barthet is studying the role of aging in cancer to improve immunotherapy strategies for elderly patients.

www.cancerresearch.org

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Lowe Lab

@LoweLabMSKCC

4 years

Tune in today to see @corina_amor_MD and @DirenaAC present their exciting work on #senolytic #CART cells & #PancreaticCancer #epigenetics . #cshlcancer20

Corina Amor MD, PhD

@corina_amor_MD

4 years

Looking forward to presenting our work on senolytic CAR T cells this morning @ #cshlcancer20 ! Watch out as well for the incredible talk by @DirenaAC this afternoon on the role of epigenetics on pancreatic carcinogenesis. @LoweLabMSKCC

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Lowe Lab

@LoweLabMSKCC

2 years

Congratulations to Margaret @m_c_kennedy on receiving the @NIH F31 Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship! 👏🎉🍾

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27

Lowe Lab

@LoweLabMSKCC

2 years

Congratulations to Issy @issy_delpriore on receiving the @MSKCancerCenter @G_B_FOUNDATION Geoffrey Beene Graduate Student Fellowship! 👏🎉🍾

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28

Lowe Lab

@LoweLabMSKCC

2 years

Cells that lose p53 undergo a deterministic pattern of genome evolution with the following order: p53 Loss Of Heterozygosity -> accumulation of Chromosomal Deletions -> Genome Doubling -> Gains & Amplifications. 4/n

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27

Lowe Lab

@LoweLabMSKCC

1 year

Happening this afternoon, postdoc @KTsanov presents brand-new work uncovering surprising roles for the SMAD4 tumor suppressor gene in metastatic pancreatic cancer. Check it out! #AACR23

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27

Lowe Lab

@LoweLabMSKCC

2 years

Congratulations to postdoc @Clemens2Hinterl on being awarded the Silver Medal of the Walter Siegenthaler Society, a prize that recognizes exceptionally innovative research projects! 👏🎉🍾

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25

Lowe Lab

@LoweLabMSKCC

8 months

The Lowe lab has had one previous reunion, 10 years after the lab’s founding. Looking forward to those of you who can make #LoweLab25 . For those who could not, we will be thinking of you!

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Lowe Lab

@LoweLabMSKCC

3 years

Congratulations to @yadirasotof , @fjsanchezrivera , @florian_perner & the whole team! A wonderful collaboration with the #AllisLab and @Armstrong_dfci , with important implications for #leukemia therapy.

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Lowe Lab

@LoweLabMSKCC

1 year

Great to have @StellaPaff back for @GSKGradSchool Commencement -- congratulations, Dr. Paffenholz! 🎓👏🍾

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24

Lowe Lab

@LoweLabMSKCC

2 years

@Corina_Amor_MD graduated ~20 years after Andy and gained acclaim for developing “senolytic” CAR T cells (). She was recently appointed @CSHL_Fellows (my 1st position!) & has become interested in aging as well @amor_lab . Stay tuned! –SWL #LoweLab25 (3/3)

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Lowe Lab

@LoweLabMSKCC

8 months

Another power couple that were dominant in the mid-2010s were Ana Banito ( @SoftSarcoma ) & Darjus @Tschaharganeh , who met working late nights in the lab. Now both are group leaders at @DKFZ in Heidelberg! -SWL #LoweLab25

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Lowe Lab

@LoweLabMSKCC

2 years

Congratulations to lead authors @TimourBaslan , @JohnPMorrisIV & Zhen Zhao @sparklingpm , and many thanks to all of our spectacular collaborators @LabNotta , @Nevenka_D , #SteveLeach @DartmouthCancer , @ciacobu @CpcrMSK , @MskccCMO @MSKCancerCenter ! 6/n

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