Cancer Grand Challenges @CancerGrand Twitter profile

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Cancer Grand Challenges

3 months

📢 Announcing five new global #CancerGrandChallenges teams! 📢 We're thrilled to announce five new teams, each receiving up to $25m over five years to tackle some of cancer's toughest challenges. Meet the teams: @CR_UK @theNCI

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Cancer Grand Challenges

@CancerGrand

9 months

📣 BREAKING NEWS 📣 We're excited to announce the 12 teams shortlisted for a #CancerGrandChallenges award. Each team has the chance to receive up to $25m to make radical progress against cancer’s toughest challenges. Discover the teams: @theNCI @CR_UK

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Cancer Grand Challenges

@CancerGrand

1 year

9 new #CancerGrandChallenges 📢 We're inviting international teams to apply for up to $25m in funding. Expressions of Interest are now open until 22 June. Explore the challenges⏬

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Cancer Grand Challenges

@CancerGrand

2 years

Announcing four new #CancerGrandChallenges teams, receiving a total of $100m to take on cancer’s toughest challenges Congratulations to the new teams 🧵 1/n @CR_UK @theNCI

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Cancer Grand Challenges

@CancerGrand

2 years

🔥OUT TODAY: clusters of #mutations identified as a major driver of tumour evolution. New @CancerGrand research published today in @Nature also joins the dots between ecDNA and APOBEC3, coining the team ‘kyklonas’ where they occur together. Learn more:

Clusters of mutations: a new driver of tumour evolution

cancergrandchallenges.org

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Cancer Grand Challenges

@CancerGrand

1 year

1/2 A @CRUKResearch funded study on the role of air pollution in the promotion of lung cancer has been published in @Nature by @CharlesSwanton - @CancerGrand Scientific Committee Member. Read Allan Balmain's ( @UCSF ) News & Views commentary @NatureNV ⏬

Air pollution’s role in the promotion of lung cancer

Nature - Cellular insights into mechanisms underlying pollution-associated cancer.

www.nature.com

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Cancer Grand Challenges

@CancerGrand

3 years

BREAKING NEWS: today we announce 11 teams selected to compete for our awards! Winners receive up to £20m each and the freedom to unleash their scientific creativity, conducting research that transcends geography and discipline - #CancerGrandChallenges

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Cancer Grand Challenges

@CancerGrand

2 years

1. Our #CancerGrandChallenges #FutureLeaders Conference 2022 started today in beautiful #Barcelona . PhD students and Postdocs from all over the world coming together as a community to help us tackle cancer's toughest challenges.

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Cancer Grand Challenges

@CancerGrand

8 months

Congratulations to Nuria Lopez-Bigas @nlbigas @IRBBarcelona , co-lead of #CancerGrandChallenges team PROMINENT, for being elected to the Spanish Royal Academy of Sciences @RACiencias 🎉 Learn more about the PROMINENT team ➡️ @CR_UK @theNCI @ContraCancerEs

PROMINENT

cancergrandchallenges.org

RACiencias

@RACiencias

8 months

En la #RACiencias damos la bienvenida a 2⃣ nuevos académic @s en la Sección de Ciencias Naturales 🌳José Manuel Moreno, Catedrático de Ecología del Departamento de Ciencias Ambientales @uclm_es 🧬Nuria López Bigas @nlbigas , dirige el grupo Cancer Biomedical Genomics

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Cancer Grand Challenges

@CancerGrand

10 months

This week, our Scientific Committee came together in New York to review the applications we got from research teams around the world, hoping to take on one of our new challenges. Narrowing 178 applications down to 10-12 is no small feat! Shortlisted teams to be announced in Sep⌛️

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Cancer Grand Challenges

@CancerGrand

20 days

Congrats #CancerGrandChallenges team Mutographs on their paper in @Nature today! Showing the power of their mutational epidemiology approach, they uncovered mutational signatures underlying global variance in #KidneyCancer incidence rates. Read: (1/5)

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Cancer Grand Challenges

@CancerGrand

11 months

New research from the #CancerGrandChallenges CANCAN team finds that a ketogenic diet slows tumour growth but shortens survival by accelerating the onset of cancer cachexia in IL-6-associated murine models of cancer cachexia 🔽 (£/$) (1/4)

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Cancer Grand Challenges

@CancerGrand

4 months

Congrats @BiffiGiulia , of #CancerGrandChallenges team CANCAN, and her lab on their new paper in @Cancer_Cell ! They've found that EGFR-activated myofibroblasts promote metastasis in pancreatic ductal adenocarcinoma (PDAC) (1/4) 👉 @theNCI @CR_UK

EGFR-activated myofibroblasts promote metastasis of pancreatic cancer

Mucciolo et al. demonstrate EGFR/ERBB2 signaling activation in myofibroblastic cancer-associated fibroblasts (myCAFs) in pancreatic ductal adenocarcinoma (PDAC). EGFR-activated myCAFs promote...

www.cell.com

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Cancer Grand Challenges

@CancerGrand

1 year

Our #CancerGrandChallenges Scientific Committee is in #NYC agreeing a new set of challenges which, if solved, could revolutionise how we approach cancer. We'll announce the challenges in March. Teams taking them on can apply for up to $25m. For updates:👇

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Cancer Grand Challenges

@CancerGrand

1 year

Huge congratulations to Nuria Lopez-Bigas @nlbigas - #CancerGrandChallenges member and ICREA Research Professor at @IRBBarcelona - for winning the 2023 Eli Lilly @FundacionLilly Award in Biomedical research 🏆

IRB Barcelona

@IRBBarcelona

1 year

🏆La Dra. @nlbigas , del #IRBBarcelona , recibe el Premio @FundacionLilly de Investigación Biomédica 2023 por sus novedosos estudios para identificar procesos generadores de mutaciones del #c áncer. ¡Enhorabuena por este gran reconocimiento!👏👏👏 ➡️ 🧵👇

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Cancer Grand Challenges

@CancerGrand

4 years

#CancerGrandChallenges is daring the world’s brightest minds to come together, think differently and unlock a new era of discovery. Explore our 9 challenges:

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Cancer Grand Challenges

@CancerGrand

1 year

Targeting ‘Bond Villain’ DNA could be a new way to tackle aggressive cancers. Congrats to Paul Mischel @mischellab and @Team_eDyNAmiC featured in @guardian for their brilliant work on #extrachromosomalDNA biology. #CancerGrandChallenges #TeamScience

‘Bond villain’ DNA could transform cancer treatment, scientists say

Discovery that extrachromosomal DNA act as cancer-causing genes seen as breakthrough that could lead to new therapies

www.theguardian.com

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Cancer Grand Challenges

@CancerGrand

3 years

"Cancer doesn’t respect national boundaries and so clinical research shouldn’t either.” Members of our scientific committee ( @CharlesSwanton , @LabVousden and David Lane) discuss the value of global collaboration in scientific research. #CancerGrandChallenges

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Cancer Grand Challenges

@CancerGrand

2 years

PROMINENT will take on the normal phenotypes challenge, seeking to identify new routes to #cancerprevention Congratulations Allan Balmain ( @UCSF ) @nlbigas ( @IRBBarcelona ) @lyonpaul ( @IARCWHO ) and the team, funded by @CR_UK , @theNCI and @ContraCancerEs 4/n

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Cancer Grand Challenges

@CancerGrand

5 months

It's been a big week for the #CancerGrandChallenges Scientific Committee and 12 shortlisted teams, who have convened in London for the final stage of their applications: interviews. Narrowing 12 down to just a few will be tough - successful teams to be announced in March '24 ⏳

Cancer Grand Challenges

@CancerGrand

9 months

📣 BREAKING NEWS 📣 We're excited to announce the 12 teams shortlisted for a #CancerGrandChallenges award. Each team has the chance to receive up to $25m to make radical progress against cancer’s toughest challenges. Discover the teams: @theNCI @CR_UK

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Cancer Grand Challenges

@CancerGrand

6 months

New research from the #CancerGrandChallenges Rosetta team, published today in @NatMetabolism , finds that pantothenic acid (also known as vitamin B5) supports Myc oncogenic metabolism and tumour progression in #BreastCancer ⬇️ (1/3)

Vitamin B5 supports MYC oncogenic metabolism and tumor progression in breast cancer

Nature Metabolism - In this study, Kreuzaler et al. perform zonal analysis to study metabolic heterogeneity in breast cancer and identify the metabolic dependency on pantothenic acid (vitamin B5)...

www.nature.com

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Cancer Grand Challenges

@CancerGrand

1 month

It was fantastic to catch up with @lillian_siu from the #CancerGrandChallenges Scientific Committee at our #AACR24 stand today (1313). Lillian was recently elected as @AACR President-Elect for 2024-2025. Huge congratulations Lillian! 🎉

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Cancer Grand Challenges

@CancerGrand

9 months

A recent @CellCellPress paper from the PRECISION team describes its development of Arc-well, a high-throughput single-cell DNA-sequencing method for profiling genomic copy number from archival formalin-fixed paraffin-embedded (FFPE) tissues ⬇️ (£/$) (1/3)

Archival single-cell genomics reveals persistent subclones during DCIS progression

Arc-well enables reliable high-throughput single-cell genomic sequencing from formalin-fixed paraffin-embedded clinical oncology samples archived for years to decades, and the application of this...

www.cell.com

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Cancer Grand Challenges

@CancerGrand

2 years

NexTGen will take on the solid tumours in children challenge & develop nextgen CAR T-cell therapies for children with #braintumours and #sarcomas Congratulations Catherine Bollard ( @ChildrensNatl ) Martin Pule ( @UCL ) and the team, funded by @CR_UK , @theNCI and @TheMarkFdn 5/n

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Cancer Grand Challenges

@CancerGrand

2 years

The eDyNAmiC team will investigate #ecDNA , found in around a third of cancers, hoping to develop much needed treatments for people whose cancer is driven in this way Congratulations Paul Mischel ( @mischellab @StanfordMed ) and the team, funded by @CR_UK and @theNCI 3/n

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Cancer Grand Challenges

@CancerGrand

9 months

In March 2023, we announced nine new challenges, with 178 interdisciplinary, world-class teams submitting bold ideas to take them on. These were narrowed down by our Scientific Committee to just 12. Tomorrow, we'll announce those 12 shortlisted teams - watch this space! 👀

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Cancer Grand Challenges

@CancerGrand

1 year

1/4 New Perspectives piece from Marios Giannakis and @KimmieNgMD of team OPTIMISTICC in @ScienceMagazine discusses the rising global incidence of early-onset colorectal cancer (EOCRC)

A common cancer at an uncommon age

The etiology of early-onset colorectal cancer needs to be understood to tackle rising incidence

www.science.org

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Cancer Grand Challenges

@CancerGrand

2 years

1. **Future Leaders Conference: Day 3** Third and final day of the #CancerGrandChallenges Future Leaders conference, and the theme was: 'Tackling Grand Challenges with a #TeamScience Approach'

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Cancer Grand Challenges

@CancerGrand

2 years

The CANCAN team will investigate #cachexia , the wasting condition often experienced in late stage cancer Congratulations @EileenWhitePhD ( @RutgersCancerInstNJ @Ludwig_Cancer ) @MarcusDGon ( @WeillCornell ) @JanowitzTobias ( @cshl ) and the team, funded by @CR_UK & @theNCI 2/n

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Cancer Grand Challenges

@CancerGrand

1 year

New challenge: Ageing and cancer Follow the thread for a deeper dive in to the first of nine new #CancerGrandChallenges announced last week⏬

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Cancer Grand Challenges

@CancerGrand

1 year

This week, we're announcing a new set of #CancerGrandChallenges , with global research teams invited to apply for up to $25m. Sign up to be the first to hear:

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Cancer Grand Challenges

@CancerGrand

1 year

Great to meet team NexTGen this week. To improve outcomes for children with #solidtumours , they're working to discover new targets in paediatric solid tumours, modulate the tumour microenvironment and develop next gen CARs to be tested in cross-continental clinical trials 👌

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Cancer Grand Challenges

@CancerGrand

2 years

Thank you to all who attended our first #CancerGrandChallenges Future Leaders Conference in Barcelona. Researchers, you impressed and inspired us. Speakers, thank you for motivating us. The event was generously supported by The Bjorn Saven Future Leaders Fund. See you next year!

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Cancer Grand Challenges

@CancerGrand

2 years

What is cancer's toughest challenge? We're leading a global conversation to identify a new set of #CancerGrandChallenges - and we want to hear from you. Have your say and help shape our next round of #funding . Submit your idea by 28 Nov: #CancerResearch

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Cancer Grand Challenges

@CancerGrand

3 years

Congratulations to @SpecifiCancer and @KatajistoLab on their latest discovery in @nature ! The team identified the molecule Notum as a key player in the early stages of apc-driven #colorectalcancer . - @owen_sansom @CRUK_BI #specificancer

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Cancer Grand Challenges

@CancerGrand

1 year

New challenge: Cancer cell plasticity This is the second of nine new #CancerGrandChallenges revealed last week. Follow the thread to find out more ⏬

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Cancer Grand Challenges

@CancerGrand

1 year

**In One Week** we’ll be announcing a new set of #CancerGrandChallenges at our annual #CGCSummit , with global research teams invited to apply for up to $25m. Find out more here ⏬

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Cancer Grand Challenges

@CancerGrand

2 years

Whether you’re a researcher, clinician, or you have been affected by cancer – we want to hear from you! Have your say: what do you think is cancer's greatest challenge? Submit your ideas and help shape our next round of funding: #CancerGrandChallenges

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Cancer Grand Challenges

@CancerGrand

2 years

Why haven’t we cured cancer? In the @guardian , team lead of our Mutographs team, Professor Sir Mike Stratton @sangerinstitute , our scientific committee member @CharlesSwanton and leading scientists @CR_UK explain why it presents such a challenge:

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Cancer Grand Challenges

@CancerGrand

2 years

Recent findings from our #Mutographs team @sangerinstitute challenge the current theory of ageing, revealing that healthy cells can tolerate many more mutations than previously assumed - watch our short animation summarising their discovery🎥👇 #mutations #genomes @drphilrobinson

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Cancer Grand Challenges

@CancerGrand

2 years

In honour of #InternationalDayofWomenInScience , we're celebrating 5 great women in our community. Hear from @KimmieNgMD , @colon_survivor , Wendy Garrett, @EleeShimshoni & Emma Lees on the importance of creating an inclusive world: #WomenInScienceDay

Spotlight: International Day of Women and Girls in Science

cancergrandchallenges.org

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Cancer Grand Challenges

@CancerGrand

4 months

Today is #WorldCancerDay . The theme is Close the Care Gap, which is about creating innovative strategies designed to confront health inequities. It's been top of mind at #CancerGrandChallenges , too - cancer inequities was among our 9 newest challenges 👇

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Cancer Grand Challenges

@CancerGrand

2 years

Following last week’s announcement of 4 new #CancerGrandChallenges teams, this week we’re exploring how each team will come together and think differently to drive progress against cancer. First up - meet the PROMINENT team, taking on our #NormalPhenotypes challenge. 🧵1/n

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Cancer Grand Challenges

@CancerGrand

10 months

In their latest review in @ScienceMagazine , the IMAXT #CancerGrandChallenges team at @CRUK_CI presents a systematic catalogue of spatial omics technologies and their perspective on the biggest challenges ahead. Read more 🔽

The dawn of spatial omics

A review discusses recent advances in methods for spatial omics.

www.science.org

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Cancer Grand Challenges

@CancerGrand

9 months

Congratulations to everyone who has been shortlisted for a #CancerGrandChallenges award! Teams have dared to take on eight new challenges that represent some of cancer’s toughest problems. Learn about the teams:

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Cancer Grand Challenges

@CancerGrand

10 months

We're excited to welcome @NCITomMisteli , Director of @NCIResearchCtr , to the #CancerGrandChallenges Scientific Committee! 👏 Tom brings his expertise as a cell biologist, having pioneered the exploration of the 3D organisation of the human genome. More 🔽

Introducing new Scientific Committee member, Dr Tom Misteli

cancergrandchallenges.org

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Cancer Grand Challenges

@CancerGrand

1 year

Day 1 of #CGCSummit , done! Thanks to our speakers for sharing their brilliant insights. We revealed 9 new #CancerGrandChallenges and held a fantastic poster session and advocacy panel. See you all tomorrow!🌞 Explore the new challenges here⏬

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Cancer Grand Challenges

@CancerGrand

2 months

Today is #InternationalWomensDay . At #CancerGrandChallenges , we're proud to have so many incredible women - across research, patient advocacy and beyond - in our global community. Meet a few of them below 👇 #IWD2024

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Cancer Grand Challenges

@CancerGrand

3 years

NEW POST: We (virtually) sat down with John Marioni, new collaborator on the Cancer Grand Challenges IMAXT programme @emblebi @CRUK_CI @sangerinstitute to find out more about his work and what excites him about the project. Read more -

7 Questions with... John Marioni, IMAXT

cancergrandchallenges.org

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Cancer Grand Challenges

@CancerGrand

4 months

"[Cancer Grand Challenges is] one of the most important international research partnerships in cancer science." 🌎 Incredible to see Lord Simon Stevens, Chair of @CR_UK , calling on the UK government to support #CancerGrandChallenges - thank you!

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Cancer Grand Challenges

@CancerGrand

2 years

A week of exciting publications from the #CancerGrandChallenges team taking on the challenge #extrachromosomalDNA - small, circular rings of DNA that can drive tumour evolution and are associated with poorer outcomes for people with cancer 🧵1/4

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Cancer Grand Challenges

@CancerGrand

1 year

TOMORROW📢 we're announcing a new set of #CancerGrandChallenges at our #CGCSummit . Tune in and watch the announcement live from 4:15pm GMT/ 11:15am EST Watch the livestream here ⏬

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Cancer Grand Challenges

@CancerGrand

9 months

📢 New blog post Hear from @Joharrr of team Rosetta @CRUK_BI about the team’s new @NatMetabolism study, where they utilised a variety of mass spectrometry techniques to investigate the metabolic consequences of common oncogenic events in #ColorectalCancer

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Cancer Grand Challenges

@CancerGrand

1 year

We’re uniting the world's brightest minds across boundaries and disciplines to tackle cancer's most complex challenges. Learn more at #AACR23 by exploring our interactive map (stand 707) ⤵️ #CancerGrandChallenges

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Cancer Grand Challenges

@CancerGrand

1 month

It was great to have Dr W. Kimryn Rathmell @NCIDirector at our stand (1313) today. #CancerGrandChallenges is a global funding initiative founded by @CR_UK and @theNCI . If you’re at #AACR24 , drop by to learn about the progress of our teams and to explore our growing community.🌎

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Cancer Grand Challenges

@CancerGrand

2 years

1. **Future Leaders Conference: Day 2** We kicked off day 2 early with a poster session. Today's theme was: 'Breakthroughs Improve Patient Outcomes'. René Bernards @NKI_nl shared 'Turning Basic Science Discoveries into Patient Benefit' + gr8 advice for #CancerGrandChallenges

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Cancer Grand Challenges

@CancerGrand

29 days

#ICYMI : In the last special issue of @CellCellPress , a stellar cast of authors (including 🔟 members of the #CancerGrandChallenges community) discuss cancer as a systemic disease and add the "clouds of complexity" to the hallmarks of cancer (1/3) Read 👉

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Cancer Grand Challenges

@CancerGrand

5 months

Did you know about the #CancerGrandChallenges Future Leaders Programme ❓ It supports future research leaders (key members of each Cancer Grand Challenges team in the early stages of their scientific careers) with events, workshops & more. Learn more 👉

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Cancer Grand Challenges

@CancerGrand

2 months

Yesterday we announced five new #CancerGrandChallenges teams 👉 , each receiving up to $25m over five years to take on cancer's toughest problems. THANK YOU to our partners & funders, whose incredible support made this possible 👏 Read more on each ⬇️

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Cancer Grand Challenges

@CancerGrand

11 months

Congratulations to Dr Caroline Young of #CancerGrandChallenges team OPTIMISTICC and @UniversityLeeds , who gave the @pathsoc CL Oakley lecture last week, and was awarded the Oakley lecture medal! Fantastic work!🏅 #LiverpoolPathology2023

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Cancer Grand Challenges

@CancerGrand

11 months

In a new @NatureRevCancer article, team OPTIMISTICC’s Geniver el Tekle & Wendy Garrett of @theGarrettLab @HarvardChanSPH explore the roles of bacteria in gastrointestinal tract malignancies and cancers of the lung, breast and prostate 🔽

Bacteria in cancer initiation, promotion and progression

Nature Reviews Cancer - The role of the microbiota in tumorigenesis has garnered considerable attention over the past two decades. In this Review, El Tekle and Garrett explore the current and...

www.nature.com

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Cancer Grand Challenges

@CancerGrand

2 years

We are finally live at #AACR22 ! Very excited to meet everyone IRL at @CancerGrand stand 1118. Plenary talk from Mike Stratton (Mutographs team lead @sangerinstitute ) on how polymerase proofreading-associated polyposis studies challenged the somatic mutation theory of ageing

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Cancer Grand Challenges

@CancerGrand

2 years

"Many cancer cells spend a long time posing as normal cells". Healthy cells tolerate many more mutations than previously assumed. Also, interesting to see high mutational rates in postmitotic tissues (non dividing cells). Follow on studies will shed further light on this #AACR22

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Cancer Grand Challenges

@CancerGrand

1 year

New challenge: Cancer inequities Find out more about the third of our nine new #CancerGrandChallenges announced last week. Follow the thread ⏬

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Cancer Grand Challenges

@CancerGrand

1 month

#AACR24 has kicked off and #CancerGrandChallenges Research Programme Manager Lorenzo de la Rica ( @LdelaRica ) has been talking about UK and European funding opportunities with an engaged audience of Early Career Researchers ⤵️ 1/2

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Cancer Grand Challenges

@CancerGrand

1 year

We loved today’s #AACR23 session on spatial technologies for mapping cancer cell architecture, chaired by Prof Emma Lundberg @Prof_Lundberg ( @Stanford ) of #CancerGrandChallenges team PROMINENT ⤵️) 1/2

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Cancer Grand Challenges

@CancerGrand

3 years

In October 2020, we launched our third and most ambitious round yet, daring the global scientific community to take on one of our 9 new challenges. With almost 170 applications, today we're announcing 11 teams who will compete for a share of £80m -

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Cancer Grand Challenges

@CancerGrand

1 month

🌟 Hello from the @AACR Annual Meeting 2024 🌟 We're uniting the world's brightest minds across boundaries and disciplines to tackle cancer's toughest challenges. If you're around, come by booth 1313 to learn more – and enjoy a free coffee while you’re here! #AACR24

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Cancer Grand Challenges

@CancerGrand

1 year

Welcome to Day 3 - the final day of #CGCSummit . Thank you to everyone who's joined us and for your insight, enthusiasm and engagement. Catch up on our new set of #CancerGrandChallenges and see you next year! Explore the new challenges⏬

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Cancer Grand Challenges

@CancerGrand

1 month

That’s a wrap for #AACR24 ! What an incredible few days of meeting fellow researchers and hearing about their innovations in cancer research. Thanks to @AACR for hosting and to everyone who came by and spoke with us. Until next time 👋

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Cancer Grand Challenges

@CancerGrand

3 months

TOMORROW'S THE DAY 🗓️ Tomorrow at 4.15pm GMT/11.15am EST, we'll be announcing the global research teams who have been awarded #CancerGrandChallenges funding of up to $25m each, to take on some of cancer's toughest challenges. Stay tuned!

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Cancer Grand Challenges

@CancerGrand

1 year

At 4:15pm GMT/ 11:15am EST today, we're announcing 9 of cancer’s toughest challenges with up to $25m funding for global research teams. Watch here: #CGCSummit #CancerGrandChallenges

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Cancer Grand Challenges

@CancerGrand

3 years

New blog post! - "There is a real dearth of information surrounding #ecDNA . But with this challenge we could unlock a whole new field of therapeutics." Professor Charlie Swanton @TheCrick discusses our extrachromosomal DNA challenge.

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Cancer Grand Challenges

@CancerGrand

1 year

We're in Madrid to continue a series of global workshops to identify new #CancerGrandChallenges . A huge thank you to British Embassy Madrid @ukinspain , Deputy British Ambassador to Spain, @HMASarahCowley , and Ramón Reyes, President of AECC @ContraCancerEs for hosting us.

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Cancer Grand Challenges

@CancerGrand

7 months

It's Day 1 of the #CancerGrandChallenges Future Leaders Conference! We've started off strong with a keynote from @CharlesSwanton , and opening remarks from our director Dr David Scott and @drsarahmoody of the Future Leaders Working Group 🌟 #FLC23 What's a future leader? 👇 (1/3)

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Cancer Grand Challenges

@CancerGrand

2 years

3 countries, 8 institutions, many disciplines: the team taking on our Solid Tumours in Children challenge unites across boundaries to develop #childhoodcancer therapies We met with members of the team to learn more @Majzner_Lab @StanfordMed #ChildhoodCancerAwarenessmonth 1/6

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Cancer Grand Challenges

@CancerGrand

1 year

**Calling on international teams 📢** We have announced 9 new #CancerGrandChallenges . To apply for funding to take them on, submit your Expressions of Interest by 22 June, 2023. Explore the challenges here ⏬

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Cancer Grand Challenges

@CancerGrand

2 years

Last week we announced the #CancerGrandChallenges CANCAN team, receiving $25m tackle our #cachexia challenge Hear more from team leads @EileenWhitePhD ( @RutgersCancerInstNJ @Ludwig_Cancer ) @MarcusDGon ( @WeillCornell ) @JanowitzTobias ( @CSHL )👇 🧵1/n

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Cancer Grand Challenges

@CancerGrand

2 years

The great work of women in @CancerGrand is helping to #breakthebias against #womeninSTEM . On #InternationalWomensDay , read our recent piece from 5 members of the community on the value of equality in science: @KimmieNgMD @EleeShimshoni @colon_survivor #IWD

Spotlight: International Day of Women and Girls in Science

cancergrandchallenges.org

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Cancer Grand Challenges

@CancerGrand

1 year

Next week, we're holding a new challenges pre-application webinar with @theNCI . There will be an opportunity for Q&A and the webinar will be recorded. Zoom details for your diary 📅 ▶️ 22 May, 4-5pm BST/ 11am-12pm ET ▶️ ▶️ Meeting ID: 161 616 6539

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Cancer Grand Challenges

@CancerGrand

1 year

Team IMAXT has found mutational processes in #ovariancancer drive different immune #phenotypes depending on anatomic sites of tumour foci. This determines immune resistance mechanisms and has important implications for early detection and therapy More 👇

Ovarian cancer mutational processes drive site-specific immune evasion

Nature - Multi-modal analysis of genomically unstable ovarian tumours characterizes the contribution of anatomical sites and mutational processes to evolutionary phenotypic divergence and immune...

www.nature.com

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Cancer Grand Challenges

@CancerGrand

1 year

New challenge: Retrotransposable elements Follow the thread to find out more about the seventh of our nine new #CancerGrandChallenges

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Cancer Grand Challenges

@CancerGrand

8 months

Today, we’re announcing a major new partnership between @cr_uk and @Institut_cancer to help fund world-class researchers to take on cancer’s toughest challenges through #CancerGrandChallenges . Read more ⤵️

Major new scientific partnership between the UK and France to tackle cancer’s toughest challenges

cancergrandchallenges.org

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Cancer Grand Challenges

@CancerGrand

1 year

New research from @Team_eDyNAmiC dissects the role of ecDNA in the transformation of Barrett’s oesophagus to cancer. @ldelarica , Research Programme Mngr at #CancerGrandChallenges , shares his insights into the importance of these new findings 🔽

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Cancer Grand Challenges

@CancerGrand

2 years

As we delve into this year’s @AACR conference, our research programme managers, @LdelaRica and Jess Sutcliffe will take over our Twitter channel and share their key takeaways over the next few days. If you’re attending the event, visit us at stand 1118 to meet more of our team!

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Cancer Grand Challenges

@CancerGrand

2 years

"Organ-Chips and Omics Advance Cancer Research" - @GENbio discusses how the @CancerGrand team @UCSFCancer are tackling our "cancer causes" challenge by using organ-chips and proteomic analyses to understand how cancer is driven by #inflammation .

Organ-Chips and Omics Advance Cancer Research

SCIEX relates that STORMing Cancer researchers are using organ-chips and proteomic analyses to understand how inflammation drives cancer.

www.genengnews.com

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Cancer Grand Challenges

@CancerGrand

6 months

Congratulations to @TaberneroJosep of @VHIO and #CancerGrandChallenges team OPTIMISTICC on being named as @CancerCoreEU 's new Chairman of the Board of Directors! What an incredible achievement. Find out more 👉

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Cancer Grand Challenges

@CancerGrand

11 months

Congratulations to Dr. @Johanna_A_Joyce of @Joycelab , and member of #CancerGrandChallenges team IMAXT, for winning the 2023 @pezcoller -Marina Larcher Fogazzaro-EACR Women in Cancer Research Award! #WomenInScience #EACR2023 🏆

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Cancer Grand Challenges

@CancerGrand

9 months

"I think it would be fair to say that Cancer Grand Challenges has played an important role in setting the cancer research agenda globally." In this blog, @Iain_CRUK , Executive Director, Research & Innovation @CR_UK reflects on #CancerGrandChallenges 🔽

The story of Cancer Grand Challenges so far

Tomorrow, we’ll reveal the shortlisted teams selected to compete for £20m ($25m) each as part of the fourth round of Cancer Grand Challenges. Across each round, we’ve been impressed by the quality...

www.linkedin.com

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Cancer Grand Challenges

@CancerGrand

1 year

**Date for your diary** Next week we're announcing a new set of #CancerGrandChallenges at our #CGCSummit . You can tune in and watch the announcement live on 8 March, 4:15pm GMT/ 11:15 EST ⏬

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Cancer Grand Challenges

@CancerGrand

9 months

Announcing 12 shortlisted teams 🚨 Meet the daring, global teams coming together and thinking differently to take on some of cancer’s toughest challenges.  Find out who's been shortlisted:

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Cancer Grand Challenges

@CancerGrand

9 months

COMING SOON: Next week, we'll be announcing the teams who've been shortlisted for a #CancerGrandChallenges award. 5 September is the date - make sure you're following us and signed up to our newsletter! 📢

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Cancer Grand Challenges

@CancerGrand

1 year

If you’re at #AACR23 , come see us at stand 707 to explore our new challenges and $25m funding opportunity ⤵️ You can also book in a chat at the stand with a member of our research team by emailing events @cancergrandchallenges .org

Nine new challenges

cancergrandchallenges.org

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Cancer Grand Challenges

@CancerGrand

2 years

Huge congratulations to Professor Carolyn Bertozzi @CarolynBertozzi of @Stanfordmed and @Stanford_ChEMH for winning the #NobelPrize . An incredible achievement! Carolyn is part of our NexTGen team working on #solidtumours in children.

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Cancer Grand Challenges

@CancerGrand

1 year

New challenge: T-cell receptors Hear from Professor René Bernards, member of our Scientific Committee, about one of our new #CancerGrandChallenges , which seeks to decipher the T-cell receptor cancer-recognition code ⬇️

T-cell receptors

Professor René Bernards talks about one of our nine new Cancer Grand Challenges: T-cell receptors. Learn more: cancergrandchallenges.org/challenges/t-cell-receptors

vimeo.com

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Cancer Grand Challenges

@CancerGrand

1 year

New challenge: Early-onset cancers Follow the thread for a deeper dive into challenge number five of nine new #CancerGrandChallenges ⏬

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Cancer Grand Challenges

@CancerGrand

1 year

We were delighted to hear @JanowitzTobias & @EileenWhitePhD of #CancerGrandChallenges team CANCAN speaking at #AACR23 today in a major symposium on systemic effects of cancer, chaired by Tobias. Learn about the team taking on our #cachexia challenge 🔽

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Cancer Grand Challenges

@CancerGrand

3 years

Shout out to our Mutographs team who are examining the damaging fingerprints left on our DNA by cancer-causing factors and hoping to identify unknown causes of cancer - . Members ft from @sangerinstitute @UCSF @IARCWHO @HeartburnCancer and @PanCanResearch .

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Cancer Grand Challenges

@CancerGrand

2 years

This #ChildhoodCancerAwarenessMonth , we’re featuring members of the team taking on our Solid Tumours in Children challenge & how they hope to bring novel cell therapies to children with sarcomas and brain tumours Learn more from co-team lead Cath Bollard

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Cancer Grand Challenges

@CancerGrand

6 months

Meet team SAMBAI, one of 12 teams who have been shortlisted for a #CancerGrandChallenges award 👏 Led by @MeliD32 of @MSMEDU , SAMBAI hopes to take on our Cancer inequities challenge, and unites investigators from four countries. Learn more 👉

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