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Nature Reviews Cancer

3 days

Our May issue is live! 🌷☀️ It features: * A Viewpoint on #fungi in cancer * A Review on combinatorial strategies for targeting #RASdrivencancer * A Review on #immunogeniccelldeath * A Perspective on #sexbias in #immunooncology Check it out👇

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Nature Reviews Cancer

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2 years

NEW content online! CRISPR in cancer biology and therapy

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1 year

NEW content online! Mechanisms driving the immunoregulatory function of cancer cells

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NEW content online! Cancer metabolism: looking forward

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And the moment you've all been waiting for... Our top downloaded article in 2023: Mechanisms driving the immunoregulatory function of cancer cells by Antoinette van Weverwijk & @deVisserKarin @NatResCancer @NKI_nl @oncodeinstitute #NRCtop10of2023

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NEW content online! Therapeutic cancer vaccines

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Our 2nd most downloaded article in 2023: Cancers make their own luck: theories of cancer origins by @RJG3062 & colleagues @NatResCancer @Gilbertson_Lab #NRCtop10of2023

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1 year

And the moment you've all been waiting for... Our top downloaded article in 2022: CRISPR in cancer biology and therapy by @alynakatti @biancaaadiaz @cmcaragine @nevillesanjana & @dow_lab @NatResCancer #CRISPR #NRCtop10of2022

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2 years

NEW content online! Structural variations in cancer and the 3D genome

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NEW content online! Mastering the use of cellular barcoding to explore cancer heterogeneity

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NEW content online! Multiplex protein imaging in tumour biology

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NEW content online! Hallmarks of sex bias in immuno-oncology: mechanisms and therapeutic implications

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10 months

NEW content online! Bacteria in cancer initiation, promotion and progression

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NEW content online! Developing dietary interventions as therapy for cancer

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NEW content online! Big data in basic and translational cancer research

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Nature Reviews Cancer

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2 years

NEW content online! Targeting CDK4 and CDK6 in cancer

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Nature Reviews Cancer

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3 years

NEW content online! Targeting the DNA damage response in immuno-oncology: developments and opportunities

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Nature Reviews Cancer

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4 months

NEW content online! Decoding the basis of histological variation in human cancer

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1 year

NEW content online! The coming decade in precision oncology: six riddles

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Nature Reviews Cancer

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3 years

NEW content online! Systemic immunity in cancer

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Nature Reviews Cancer

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2 years

Our 6th most downloaded article of 2021: Antigen presentation in cancer: insights into tumour immunogenicity and immune evasion by S Jhunjhunwala, C Hammer & L Delamarre #ImmuneEvasion #ImmuneCheckpointInhibition @genentech @NatResCancer #NRCtop10of2021

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Nature Reviews Cancer

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1 year

NEW Review! @deVisserKarin and A. van Weverwijk outline how inter-tumoural #heterogeneity in tumour #immunelandscapes is shaped by cancer cell-intrinsic alterations and how their crosstalk impacts #Immunotherapy @natrescancer @NKI_nl @oncodeinstitute

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Nature Reviews Cancer

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3 years

NEW content online! Metabolic networks in mutant KRAS-driven tumours: tissue specificities and the microenvironment

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Nature Reviews Cancer

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2 years

NEW Review! @alynakatti @biancaaadiaz @cmcaragine @nevillesanjana & @dow_lab outline the ENORMOUS progress that has been made in the application of #CRISPR tools to the study of #cancer & describe their potential use in diagnosis & treatment @natrescancer

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Nature Reviews Cancer

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2 years

Our 3rd most downloaded article of 2021: The metabolism of cancer cells during metastasis by G Bergers @BergersLab & S-M Fendt @FendtLab #cancermetabolism #metastasis #NRCtop10of2021

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Nature Reviews Cancer

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3 months

NEW content online! Beyond genetics: driving cancer with the tumour microenvironment behind the wheel

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Nature Reviews Cancer

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5 years

2019 #NobelPrize winner William Kaelin @kaelin_lab wrote a Perspective article for the journal in 2017 on Common pitfalls in preclinical cancer target validation that many have said should be 'required reading'. Access it for free here:

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Nature Reviews Cancer

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2 years

NEW content online! Towards targeting of shared mechanisms of cancer metastasis and therapy resistance

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2 years

NEW content online! Immunobiology of high-grade serous ovarian cancer: lessons for clinical translation

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Nature Reviews Cancer

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3 years

NEW content online! Leukaemia: a model metastatic disease

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Nature Reviews Cancer

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3 years

NEW content online! Cancer stem cell–immune cell crosstalk in tumour progression

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Nature Reviews Cancer

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2 months

In case you missed it, out NOW @ElaineFuchsLab @greatysp & @almagro_jorge discuss the non-genetic drivers of tumorigenesis & progression – it’s not all about mutations! #tumourmicroenvironment @natrescancer @RockefellerUniv @HHMINEWS

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Nature Reviews Cancer

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4 years

New Perspective! Marine, Dawson & Dawson discuss how therapeutic #resistance in cancer is not only driven by genetic evolution but often involves nongenetic adaptive mechanisms that are intimately linked. @NatResCancer @lab_marine @TheDawsonLab @MAFD110

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Nature Reviews Cancer

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3 years

NEW content online! Stress and cancer: mechanisms, significance and future directions

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Nature Reviews Cancer

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3 years

NEW content online! The immunological and metabolic landscape in primary and metastatic liver cancer

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Nature Reviews Cancer

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2 years

And the moment you've all been waiting for... Our top downloaded article in 2021: Systemic immunity in cancer by K Hiam-Galvez @InflammatoryDC , B Allen @ballen1725 & M Spitzer @SpitzerLab @UCSFCancer @UCSF #NRCtop10of2021

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Nature Reviews Cancer

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3 years

NEW content online! Glial and myeloid heterogeneity in the brain tumour microenvironment

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2 years

NEW content online! Mechanisms of immune activation and regulation: lessons from melanoma

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Nature Reviews Cancer

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3 months

NEW content online! Linking cell mechanical memory and cancer metastasis

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Nature Reviews Cancer

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2 years

NEW Review! @zervanto & colleagues discuss mechanisms by which tumour ecosystems adapt to therapeutic stresses and how adaptive responses could be targeted to overcome cancer therapy resistance. @natrescancer @UPMCHillmanCC @OHSUNews @harvardmed

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Nature Reviews Cancer

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2 months

NEW content online! Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity

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1 year

Our 6th most downloaded article in 2022: Towards targeting of shared mechanisms of cancer metastasis and therapy resistance by Peter Friedl & colleagues @NatResCancer @MDAndersonNews @radboudumc @radboudumc_weet #Metastasis #NRCtop10of2022

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Nature Reviews Cancer

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5 months

NEW content online! Fcγ receptors and immunomodulatory antibodies in cancer

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Nature Reviews Cancer

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3 years

NEW content online! Synthetic biomarkers: a twenty-first century path to early cancer detection

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3 years

NEW content online! The language of chromatin modification in human cancers

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Nature Reviews Cancer

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2 years

NEW Perspective! Friedl et al outline how exploitation of signalling pathways shared between those enabling #Metastasis and those in #TherapyResistance might result in better therapies. @natrescancer @MDAndersonNews @Radboudumc @Radboudumc_weet

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Nature Reviews Cancer

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1 year

Our 2nd most downloaded article in 2022: Natural killer cells in antitumour adoptive cell immunotherapy by Katy Rezvani @lab_rezvani & colleagues @NatResCancer #NRCtop10of2022

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Nature Reviews Cancer

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15 days

Tumour-associated lymphatic growth & remodeling were once viewed as passive means for lymphatic spread. In this #Review , @theLundLab provide a working framework for the role of the lymphatic system in tumour progression & response to immunotherapy.

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Nature Reviews Cancer

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2 years

Attending Ton Schumacher's talk at #AACR2022 ? Have a look at his @NatureRevCancer Review: #CD8 + T cell states in human cancer: insights from single-cell analysis; @NatResCancer @NKI_nl

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Nature Reviews Cancer

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3 months

Our 8th most downloaded article in 2023: The neural addiction of cancer by Claire Magnon & Hubert Hondermarck @NatResCancer @inserm #NRCtop10of2023

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Nature Reviews Cancer

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21 days

NEW content online! Lymphatic vessels in the age of cancer immunotherapy

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Nature Reviews Cancer

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3 years

In our September issue: The immunological and metabolic landscape in primary and metastatic liver cancer, by M Heikenwalder @CancerInflam et al. @natrescancer #livercancer #immunology #metabolism @DKFZ

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Nature Reviews Cancer

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3 years

NEW Review! GG Wang & co discuss the many connections between #chromatin modifications and #cancer , going into recent advances and highlighting options for therapeutic targeting. @NatresCancer @UNC_SOM @UNC_Lineberger

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Nature Reviews Cancer

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2 years

In the March issue of @NatureRevCancer | Towards targeting of shared mechanisms of #cancer #metastasis & #therapyresistance by F Weiss, D Lauffenburger & P Friedl @natrescancer @MDAndersonNews @radboudumc @radboudumc_weet #CancerTherapy

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Nature Reviews Cancer

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3 years

In our August issue | Metabolic networks in mutant KRAS-driven tumours: tissue specificities and the microenvironment, by Costas Lyssiotis @LyssiotisLab et al. @UMRogelCancer @YatrikShahLab @ThalesPapaG #KRAS #cancermetabolism #NSCLC #CRC #PDAC

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Nature Reviews Cancer

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5 months

NEW content online! How chemokines organize the tumour microenvironment

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2 years

NEW content online! Liquid–liquid phase separation drives cellular function and dysfunction in cancer

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Nature Reviews Cancer

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3 years

In our August issue | Cancer stem cell–immune cell crosstalk in tumour progression, by Defne Bayik & Justin D. Lathia @d_bayik @JustinLathia @caseccc @CCLRI @NatResCancer #tumorimmunology #tumormicroenvironment #cancerstemcell #CSC #immunecell

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Nature Reviews Cancer

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3 years

NEW content online! Interleukins in cancer: from biology to therapy

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Nature Reviews Cancer

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3 months

Our 6th most downloaded article in 2023: Dynamics and specificities of T cells in cancer immunotherapy by Giacomo Oliveira & Cathy J. Wu @NatResCancer @DanaFarberNews @harvardmed #NRCtop10of2023

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Nature Reviews Cancer

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4 years

Our NEW Review by @AshaniTW and @FaneMitchell discusses the interplay between ageing cell types in the #microenvironment and cancer cells and how this is likely to impact tumour #metastasis and #cancertherapy response. @NatResCancer

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Nature Reviews Cancer

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3 years

NEW content online! Overcoming TGFβ-mediated immune evasion in cancer

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Nature Reviews Cancer

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2 months

NEW content online! Extrachromosomal DNA in cancer

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2 years

NEW content online! Exploiting senescence for the treatment of cancer

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Nature Reviews Cancer

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3 years

🎉🍾Nature Reviews Cancer is 20! To celebrate we have put together an anniversary issue with articles that look towards the future of cancer research. All reviews, perspectives and commentaries in the issue are FREE to access for 1 month starting today.

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Nature Reviews Cancer

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6 years

Check out our NEW article by Stefani Spranger & Thomas F. Gajewski discussing how oncogenic tumour pathways can mediate immune evasion & the possibility of targeting these pathways to overcome #immunotherapy resistance

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Nature Reviews Cancer

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3 years

NEW Review! Nobuyuki Kakiuchi & Seishi Ogawa discuss recent findings on #ClonalExpansion in non-cancer tissues and their biological significance in cancer development, ageing and inflammatory diseases. @NatResCancer @KyotoU_News @karolinskainst

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Nature Reviews Cancer

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3 years

In our May issue: Linking #EMT programmes to normal and neoplastic epithelial stem cells, by AW Lambert & Bob Weinberg. @WhiteheadInst @MITBiology @NatResCancer

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Nature Reviews Cancer

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2 years

Regarding somatic mutations in normal tissues #AACR2022 , check out this @NatureRevCancer review by Nobuyuki Kakiuchi & Seishi Ogawa: Clonal expansion in non-cancer tissues, @NatResCancer @KyotoU_News @karolinskainst

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Nature Reviews Cancer

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3 years

NEW content online! Evolving cancer–niche interactions and therapeutic targets during bone metastasis

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Nature Reviews Cancer

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4 years

Want to hear more about @AshaniTW ’s opening plenary talk on how the ageing microenvironment influences #tumour progression & #therapy response? Have a read of her Review here: #AACR20

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Nature Reviews Cancer

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3 months

Our 3rd most downloaded article in 2023: mRNA-based cancer therapeutics by Na Kong, Wei Tao & colleagues @NatResCancer @WeiTaoLab @BrighamWomens @Harvardmed #NRCtop10of2023

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Nature Reviews Cancer

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2 months

#ecDNA is a major contributor to #cancer #pathogenesis . Here, Xiaowei Yan, @HowardYChang & @mischellab provide new insight into the biogenesis + maintenance of ecDNA, & its role in altering gene expression + promoting #tumourheterogeneity .

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Nature Reviews Cancer

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2 years

Our 8th most downloaded article of 2021: The matrix in cancer, by Thomas Cox @thomasrcox . @TCox_Lab @GarvanInstitute @NatResCancer #NRCtop10of2021

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Nature Reviews Cancer

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3 years

Our 3rd most downloaded Review of 2020: The cancer–natural killer cell immunity cycle Nicholas D. Huntington, Joseph Cursons & Jai Rautela @Dr_Nick_Bikes @JoeCursons @onko_innate @MonashBDI

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Nature Reviews Cancer

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4 years

Our NEW Review out NOW from @GoetzJacky @paultimpson7 & colleagues from @INSERM @GarvanInstitute discusses the role of bodily fluids & their underlying forces & imposed stresses in shaping #metastasis . Why not have a read here.... @NatResCancer

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Nature Reviews Cancer

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3 months

In case you missed it... #Transposableelements , or junk DNA, constitute nearly 1/2 the #humangenome . @twang5 and colleagues discuss how tumours exploit transposable elements during their evolution & how they could be targeted by immunotherapies.

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Nature Reviews Cancer

@NatureRevCancer

5 years

As a scientist have you ever wondered why you might want a Twitter account? Well find out why in our NEW Comment article by @SoragniLab & @aiims1742 . With lots of helpful tips to get you started....Free to view here.... #ofscientistsandtweets @NatResCancer

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Nature Reviews Cancer

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5 years

Most studies looking at therapy resistance have focused on tumour-intrinsic changes, yet it's now clear that host responses to different cancer therapies can contribute to tumour regrowth, spread & resistance. Find out more in our Review from Yuval Shaked

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Nature Reviews Cancer

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3 years

NEW content online! The plasticity of mRNA translation during cancer progression and therapy resistance

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Nature Reviews Cancer

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2 years

Did you know that some patients show extraordinary responses to #cancer treatments? What can we learn from these patients to improve responses in more typical patients? Find out more in this Perspective from 2019 by @PrDavidBowtell & colleagues: #Edpicks

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Nature Reviews Cancer

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2 years

NEW content online! The role of ROS in tumour development and progression

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Nature Reviews Cancer

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2 years

In the Nov issue of @NatureRevCancer | Targeting the DNA damage response in immuno-oncology: developments and opportunities, by Sophie Postel-Vinay @sophiepostelvi1 , @jsoriamd & co. @natrescancer @GustaveRoussy

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Nature Reviews Cancer

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2 years

NEW content online! Cancer proteogenomics: current impact and future prospects

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Nature Reviews Cancer

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5 years

Check out our NEW article by Erik Thompson & colleagues @QUT outlining the evidence for epithelial–mesenchymal plasticity in #metastasis , focusing on recent challenges & controversies, & highlighting strategies to target the process. #EMT @NatResCancer

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Nature Reviews Cancer

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2 years

NEW Review! Wang, Lankhorst & Bernards discuss how #senescence can be induced in cancer cells and how features of senescent cancer cells might be exploited as potential therapy. @natrescancer @oncodeinstitute @NKI_nl

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Nature Reviews Cancer

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2 years

NEW content online! Disconnecting multicellular networks in brain tumours

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6 months

NEW content online! Metabolic pathway analysis using stable isotopes in patients with cancer

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Nature Reviews Cancer

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4 years

New Review online! S Jaillon, A Mantovani & co discuss the emerging dual role of #neutrophils in the TME as part of tumour-promoting #inflammation , while also mediating antitumour immune responses. @NatResCancer @HumanitasMilano @QMUL #cancerimmunology

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Nature Reviews Cancer

@NatureRevCancer

3 years

Check out the "Milestones in Cancer"! The last 20 years of basic, transl. & clinical research. A community effort by editors from across @NatResCancer . Coordinated by @NatureMedicine & @NatureGenetics . Enjoy! Timeline: Collection:

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Nature Reviews Cancer

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2 years

NEW content online! Tumour-infiltrating B cells: immunological mechanisms, clinical impact and therapeutic opportunities

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Nature Reviews Cancer

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2 years

Interested in #DrugResistance #AACR2022 ? @NatureRevCancer has got your back: Therapy resistance: opportunities created by adaptive responses to targeted therapies in cancer, by @zervanto & colleagues. @natrescancer @UPMCHillmanCC @OHSUNews @harvardmed

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Nature Reviews Cancer

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1 year

Our 5th most downloaded article in 2022: Developing dietary interventions as therapy for cancer by @MarcusDGon @CantleyLab & colleagues @natrescancer #cancermetabolism #NRCtop10of2022

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Nature Reviews Cancer

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7 years

NEW Review: Dranoff, Engelman & colleagues on combining targeted and conventional therapies with immunotherapy

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5 years

NEW Review by @MiriamMerad @HeleneSalmon & colleagues discusses how differences in tissue sites may influence the antitumour immune response, with potential implications for novel therapeutics. #immunotherapy @NatResCancer @IcahnMountSinai @institut_curie

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Nature Reviews Cancer

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4 months

NEW content online! Towards targeting transposable elements for cancer therapy

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Nature Reviews Cancer

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2 years

NEW Review! @samuels_yardena @JenWargoMD et al. discuss the mechanisms underlying the immune response to #melanoma as well as the mechanisms of response & resistance of these tumours to #immunotherapies @natrescancer @WeizmannScience @MDAndersonNews

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Nature Reviews Cancer

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3 years

Our 8th most downloaded Review of 2020: Role of RNA modifications in cancer from @Isaiabarbieri and Tony Kouzarides @TKLABUK

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Nature Reviews Cancer

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3 years

NEW content online! Mitochondrial DNA variation and cancer

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Nature Reviews Cancer

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3 months

NEW content online! Translating p53-based therapies for cancer into the clinic

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Nature Reviews Cancer

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5 years

NEW Review from Tim Chan ( @GeneCollector ) & colleagues @sloan_kettering discusses many factors affecting immune checkpoint inhibitor efficacy: tumour genomics, germline genetics, PDL1 levels, tumour microenvironment, microbiome #Immunotherapy @NatResCancer

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