Lyssiotis Lab @LyssiotisLab Twitter profile

Pinned Tweet

Lyssiotis Lab

7 months

Collectively inspired Lyssiotis Lab Mission Statement. Thanks to @radykm for the encouragement. Thanks to me for the word cloud 😄 cc: @UMPhysiology , @UMRogelCancer , @UMICHpancreas , @UmichCancBio

6

10

79

Last Seen Profiles

@EvMYCPioDrYbwce

@GonnaSkyeBy

@F05ez

@Scott_Oatley_

@GOMITA_OFICIAL

@3RY8S6MgH80FmmX

@NavarroBball

@turbancorap00

@_DeusaAthenna

@MichaelFilipiuk

@SigmaEleMent

@ItsKittyRosie

@Samaritans_Thai

@OssiMenache

@OfficialRomp

@5D8QC1Kp0o8kGtA

@YFYWwPsOdo1Nn7Q

@OnPointMMA

@MajorCantrell8

@Heeseiung

@Iam_OmobolanleE

@TSenchantress

@Jel__official

@ShLetsMeet

@Hunter_Burton04

@MasonSoftball

@Sinderella_SC

@Mio_N_draw

@lawyerJammy

@AyudaClubes_Pro

@MalliRoshnbiran

@KelownaNow

@lC35yr4dqJTF0ww

@ajegs007

@TeddyBlackBerry

@cirachyasawsxn1

Lyssiotis Lab

@LyssiotisLab

2 years

This is nuts! Cancer cells hide inside other cancer cells so that immune attacks that damage the outer membrane keep the cells inside safe! @eLife Hide and seek

Hide and seek

Cancer cells hide inside each other when the immune system attacks.

elifesciences.org

16

196

780

Lyssiotis Lab

@LyssiotisLab

5 years

Dear undergraduates: doing a PhD will require you to embrace failure! Being smart or a good student does not = a PhD. You have to love the work so much that you can handle the failure. Most experiments don’t work, even when you do them right.

Failing is a key part of PhD success

Nature - Students must learn that a doctoral degree isn’t for everyone — and that not doing one might be a better option.

www.nature.com

8

251

603

Lyssiotis Lab

@LyssiotisLab

3 years

🎉 TENURE @umichmedicine 🎉 Deeply humbled & honored. So many thanks: awesome team in @LyssiotisLab ; colleagues, collaborators in @UMPhysiology , @UMRogelCancer , @UMICHpancreas ; & mentors. Will use to support our scientific & training missions w/ greater enthusiasm & creativity.

121

11

470

Lyssiotis Lab

@LyssiotisLab

11 months

🔥Hot paper alert 🔥 New one from @zeribechike , Matt Ward, @Sajjakulnukit , Pawan Poudel, et al. out today @Nature #OpenAccess Buckle up for the tweetorial 1/n

54

112

389

Lyssiotis Lab

@LyssiotisLab

3 years

1/ Our new work is out today @NatureComms , led by @DMKremer1 **GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis** Strap in, #GoT -themed, pun-laden #tweetorial coming at you.

31

56

283

Lyssiotis Lab

@LyssiotisLab

2 years

Kicking off the new year with a new publication in @eLife ! Congrats to co-leads Peter Kim, @CJHPhD , Sam Kerk and our awesome team of collaborators: @radykm ; @sawisner ; @DMKremer1 ; @Sajjakulnukit ; @MattRPratt ; @KeshariLab ; @HaoqiangY . #Tweetorial (1/12)

29

44

234

Lyssiotis Lab

@LyssiotisLab

4 years

What an honor to be considered among this brilliant group of scientists! Thanks @trendscancer for the opportunity to share our perspective on Tumor Microenvironment Metabolism as an important area of Future Cancer Research! cc: @UMRogelCancer , @UMPhysiology , @UMICHpancreas

Trends in Cancer

@trendscancer

4 years

What does the future of cancer research look like? Rising leaders in the field @LyssiotisLab @LeilaAkkari1 @Tanner_Lab @Samuel_Bakhoum @stefanispranger @TurajlicLab @KrishnaswamyLab @sidichen share their perspective

1

18

49

14

27

223

Lyssiotis Lab

@LyssiotisLab

2 years

Honored to receive this support & recognition from the Maisel family. My biggest and most sincere thanks to Eric Fearon ( @UMRogelCancer ), my mentors, colleagues (which includes trainees!), and my absolutely awesome lab. Feeling very grateful 😊 cc: @UMPhysiology , @UMICHpancreas

U-M Rogel Cancer Center

@UMRogelCancer

2 years

#RogelCancer researcher @LyssiotisLab was appointed to the Maisel Research Professorship in Oncology. Congratulations, Dr. Lyssiotis!

14

8

72

59

8

209

Lyssiotis Lab

@LyssiotisLab

1 year

Hyping new @SciImmunology from @_Hanna_Hong (before #Twitter burns down 🔥) ➡️OXPHOS Promotes Apoptotic Resistance and Cellular Persistence in TH17 cells in the Periphery and Tumor Microenvironment ⬅️ Read on for a #tweetorial

13

56

194

Lyssiotis Lab

@LyssiotisLab

2 years

The Lyssiotis Metabolomics Lab is live and it’s 🔥🔥 (though most of the instruments are still in the loading dock 😯🤪). Stay tuned for updates 💪🏼 cc: @UMPhysiology , @UMRogelCancer , @UMICHpancreas

13

10

193

Lyssiotis Lab

@LyssiotisLab

2 years

@tmorello @Harvard @CarolynBertozzi @NobelPrize I didn’t think it possible that @CarolynBertozzi would find a way to be any cooler. Achievement unlocked. Tom. Morello. 🤯🤘🏼

2

3

172

Lyssiotis Lab

@LyssiotisLab

3 years

1/ So excited to see this out! CONGRATS to lead @UmichCancBio , @UMRogelCancer Grad Student Sam Kerk and HUGE thanks to @UlrikeHarjes for editorial input, suggestions, and support! Please read on for brief highlights. cc: @YatrikShahLab , @ThalesPapaG , @UMPhysiology , @UMICHpancreas

Nature Reviews Cancer

@NatureRevCancer

3 years

NEW content online! Metabolic networks in mutant KRAS-driven tumours: tissue specificities and the microenvironment

1

58

198

2

47

170

Lyssiotis Lab

@LyssiotisLab

3 years

📣Over the moon to share the good news: @UmichCancBio Grad Student Sam Kerk awarded an @NCICancerBio F99/K00 (scored a *12* 💪🏼). Dude is a rockstar. PIs, take notice, he’s on the job market! So proud of him! Pictured at his wedding with co-mentors @YatrikShahLab , @LyssiotisLab .

13

6

163

Lyssiotis Lab

@LyssiotisLab

2 years

#MetaboTwiitter , you’ve GOT2 check out our new work on #PancreaticCancer #TumorMetabolism in @eLife , led by the indominable Sam Kerk, @UmichCancBio ; co-directed @YatrikShahLab . cc: @UMPhysiology , @UMRogelCancer , @UMICHpancreas Read on for full #Tweetorial

Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context

Inhibition of GOT2 drives growth inhibitory reductive stress that can be rescued by electron acceptors in vitro, whereas GOT2 inhibition in endogenous or transplanted tumor models is tolerated...

elifesciences.org

14

38

146

Lyssiotis Lab

@LyssiotisLab

3 years

Super cool to see this live on the @NatureRevCancer website! 👉Get your free access here: cc: @YatrikShahLab , @ThalesPapaG

2

34

141

Lyssiotis Lab

@LyssiotisLab

3 years

Honored and thrilled to join the editorial board at @SN_Oncology #CancerandMetabolism ! Humbled to be among this team of Allstars and Opinion Leaders. Look forward to working with all the cancer metabolism researchers and authors!

17

3

133

Lyssiotis Lab

@LyssiotisLab

7 months

Rest assured, tickets will not sell out for this concert. You all have @Nickleotide to thank for this gem #Kras #Eras

18

2

131

Lyssiotis Lab

@LyssiotisLab

2 years

Get on the Hype Train 🚂💪 Superstar Postdoc @mbah_nneka dropped her work @biorxivpreprint : **Therapeutic targeting of differentiation state-dependent metabolic vulnerabilities in DIPG**. Our first foray into DIPG. Brief highlight reel 🧵

6

36

127

Lyssiotis Lab

@LyssiotisLab

2 months

Commemorating the first, annual Seth Boyer Award for Excellence in Research, in memory of Seth, a @UMPhysiology student in the lab. Seth was an extremely bright, hard-working, thoughtful, diligent scientist. He never backed down from a challenge and made important contributions…

6

22

125

Lyssiotis Lab

@LyssiotisLab

2 years

🚨 New paper alert 🚨 In @BiochemistryACS , we describe discovery & characterization of novel allosteric inhibitor of cytosolic Malic Enzyme 1. Inherent in this discovery is the first description of a novel allosteric, drugable pocket in ME1. #OpenAccess

4

30

122

Lyssiotis Lab

@LyssiotisLab

2 years

🚨 New paper alert 🚨 Check out @DMKremer1 's review @nchembio on small molecule targeting of allosteric pockets in metabolic enzymes. We discuss mechanistic insights garnered, close with technologies to find the next generation of allosteric modulators.

4

31

119

Lyssiotis Lab

@LyssiotisLab

1 year

The @LyssiotisLab has had a lot to celebrate these past few months - so much so, that Gillian made a flyer 😍 Way to go Team 🙌🏼 Impressed and proud of all the accomplishments. cc: @UMICHpancreas , @UMRogelCancer , @UMPhysiology

16

11

117

Lyssiotis Lab

@LyssiotisLab

5 years

Thread (1/11). Welcome to the lab's 1st #tweetorial ! Some may be aware of this study ( #belatedtweetorial ) published in @Cell_Metabolism in June. Kudos to lead @CJHPhD ; took a village #MarinaPasca , @jen_morton , @HCCvPDAC , @WWCRC_GPOL , @JiaqiShi , et al.

4

31

116

Lyssiotis Lab

@LyssiotisLab

4 years

#TumorMetabolism Twitter: if you are tuning into the @AACR , please consider joining us at 1:30PM EST for the session on "Exploiting Metabolic Vulnerabilities in Cancer". Check out this awesome speaker line-up 👇. #OliverMaddocks , @LabDeNicola , @AyeletErez , @LyssiotisLab

10

13

114

Lyssiotis Lab

@LyssiotisLab

4 years

1/ I purposely avoid political issues with this account. However, I simply cannot keep quiet on this (👇). Two extremely talented postdocs in @LyssiotisLab are Nigerian. These scientists are using their brilliance to make new discoveries to treat #pancreaticcancer and #DIPG .

The Wall Street Journal

@WSJ

4 years

The Trump administration plans to place travel restrictions on seven more countries, including Nigeria, say officials who have seen the list

25

172

154

4

33

113

Lyssiotis Lab

@LyssiotisLab

2 years

🚨Job Posting: The @YatrikShahLab & @LyssiotisLab are looking for a postdoc to study the role of iron, O2, & metabolism in erythropoiesis. Opportunities to learn and employ multiple cutting-edge technologies in 2 ~pretty cool labs 😁 DM with interest.

1

67

112

Lyssiotis Lab

@LyssiotisLab

4 years

Humbled to be considered among this group of rising stars! ⭐️🙏🏻

Cell Press

@CellPressNews

4 years

The Future of Cancer Research @LeilaAkkari1 @Samuel_Bakhoum @KrishnaswamyLab @sidichen @stefanispranger @Tanner_Lab @lyssiotis @SamraTurajlic @trendscancer

5

45

255

4

6

113

Lyssiotis Lab

@LyssiotisLab

4 years

Sending both huge congrats & my excitement to @PeggyPHsu , the inaugural @UMRogelCancer Fellow! cc: @TheSpenceLab , @YatrikShahLab

18

10

113

Lyssiotis Lab

@LyssiotisLab

3 years

Back at it w/ another #tweetorial on latest @biorxivpreprint ! Congrats co-leads Matt Ward, @zeribechike , Pawan Poudel! Long running collaboration with our good friends in @LabSadanandam and @Biolog (1st project in @Lyssiotislab , ~circa '15). 🙏🏼collaborators: @Pasca_Lab , @CJHPhD

4

23

112

Lyssiotis Lab

@LyssiotisLab

1 year

Hey Mom! I’m in the #URecord ! Grateful for the unending support of @LyssiotisLab , @UMPhysiology , @UMRogelCancer , @UMICHpancreas colleagues & mentors, and to @SantaJOno , @UMLifeSciences for the recognition 🙏🏼 Hearty round of congrats to co-recipients! 🎉

14

6

111

Lyssiotis Lab

@LyssiotisLab

2 years

Fascinating paper in @CR_AACR describing how exercise influences organ metabolism, impairing metastasis. Mix of preclinical data and provocative correlative patient data.

1

16

105

Lyssiotis Lab

@LyssiotisLab

4 years

This new review is a must read for trainees in Cancer Biology (cc: @UmichCancBio ). "The Hallmarks of Cancer are also the Hallmarks of Wound Healing" @scisignal Reminder of the famous quote: Cancer as a wound that never heals.

2

38

102

Lyssiotis Lab

@LyssiotisLab

3 years

1/ This is NUTS! Humbled and honored 🙏🏼. A testament to collaborative science and awesome mentors and collaborators!! @CantleyLab , #KimmelmanLab , @RonDePinho , @HaoqiangY , @DraettaG , @LabSadanandam […]

UMPhysiology

@UMPhysiology

3 years

Congratulations to @LyssiotisLab and Jun Wu from @UMPhysiology for being recognized as #HighlyCited2020 investigators. @UMRogelCancer @UMLifeSciences

2

4

26

10

9

102

Lyssiotis Lab

@LyssiotisLab

2 years

2022 Lyssiotis Lab Retreat @umich Botanic Gardens. Great day of science & camaraderie. Such a pleasure & blessing to work with this brilliant, dedicated group of scientists. See thread for pics and thanks, if you’re into that sort of thing 😁 cc: @UMPhysiology , @UMRogelCancer

4

8

101

Lyssiotis Lab

@LyssiotisLab

4 years

(1/3) Big month for @LyssiotisLab . July marks our 5yr anniversary, which will be celebrated with *Back-to-Back* dissertations from the first 2 grad students: @biologist_barb , @DMKremer1 ! Please send them a line or join in celebrating their momentous achievements! *DM for link

6

8

100

Lyssiotis Lab

@LyssiotisLab

4 years

1/ Psyched to share a #Tweetorial for our new collaborative study (on behalf of the #Twitterfree Zou lab @umichmedicine , @UMRogelCancer , @umichsurgery )! Out in @nature : “Cancer SLC43A2 alters T cell methionine metabolism and histone methylation”.

Cancer SLC43A2 alters T cell methionine metabolism and histone methylation

Nature - Expression of the transporter SLC43A2 by tumour cells allows them to outcompete T cells for methionine and thereby disrupt the survival and function of tumour-infiltrating T cells.

www.nature.com

7

26

98

Lyssiotis Lab

@LyssiotisLab

8 months

Nucleoside metabolism lovers, consider reading our new, mini-review on uridine as a metabolic fuel. Live in @cell_res . Kudos to the authors, Matt Ward ( @WUSTL ) & @zeribechike ( @UMPhysiology , @UMRogelCancer ). PDF access here 👉🏼

5

27

99

Lyssiotis Lab

@LyssiotisLab

3 years

My Mom on the vaccination front!! Go Mom!

Jon Hewett

@JonHewettWWJ

3 years

HAPPENING NOW... Oakland County has begun vaccinating emergency response personnel by drive through at the Waterford Township Fire Department. 100 appointment only vaccines today out of the initial batch of 1,950 doses of the Pfizer vaccine received. Updates @WWJ950

0

3

8

2

1

99

Lyssiotis Lab

@LyssiotisLab

1 year

The *Hallmarks of Scientific Communication* as conceived with @airdlab during the #cmsw23 Science Communication Breakout session 🤪 Design courtesy of @Nickleotide This is meant to be funny, but it’s also true. Enjoy.

4

19

94

Lyssiotis Lab

@LyssiotisLab

4 years

1/9 Pleased to share a #tweetorial on our latest #OpenAccess work in @CommsBio !

High-content fluorescence imaging with the metabolic flux assay reveals insights into mitochondrial...

Communications Biology - Little, Kovalenko et al. couple the metabolic flux assay from the Seahorse bioanalyzer with high-content fluorescence imaging to study the coordinated biology of...

www.nature.com

4

34

95

Lyssiotis Lab

@LyssiotisLab

2 years

THE. MAN. We are so proud of you for earning this well deserved recognition. The future is bright 🤩 Bonus: Few of my favorite pics, for fun.

Zeribe Nwosu

@zeribechike

2 years

I am happy to share that I was awarded the NIH K99/R00 grant. This is a phenomenal opportunity for me to prepare for a future faculty position where I look forward to learning from future colleagues, training scientists, and exploring ways to defeat cancer.

45

25

798

8

93

Lyssiotis Lab

@LyssiotisLab

1 year

Please join us in congratulating the newly minted **Dr. Sam Kerk** 🙌🏼👏🏼🥳 What an ace. Presentation was top notch. So proud of this guy’s many accomplishments. cc: @UmichCancBio , @UMRogelCancer , @UMPhysiology , @YatrikShahLab

7

8

92

Lyssiotis Lab

@LyssiotisLab

4 years

Thanks @TheMarkFdn for supporting our work on #PancreaticCancer #metabolism . This comes at a pivotal time to truly accelerate these studies!! And, always thrilled to partner with Lew @WeillCornell 😃 Hearty congrats to @kevansf , @megeblad 🎉🥂 cc: @UMPhysiology , @UMRogelCancer

The Mark Foundation for Cancer Research

@TheMarkFdn

4 years

Proud to announce funding for four projects that involve novel strategies for developing anti-cancer therapies CC: @UPMCnews , @UMRogelCancer , @WeillCornell , @UCSFCancer , @CSHL

2

11

37

11

10

88

Lyssiotis Lab

@LyssiotisLab

7 months

New @LyssiotisLab swag is in… and it’s lit 🔥 Thanks to Narges for design and @HeatherGiza for artwork 🙌🏼

8

4

87

Lyssiotis Lab

@LyssiotisLab

8 months

Teamed up with @YatrikShahLab , @MaraShermanLab , @KivancBirsoy , and @JaviGBermudez to write a review on the functions of GOT2 in cancer metabolism. You’ve GOT2 check it out! #OpenAccess Kudos to lead, Dr. Sam Kerk!

0

21

87

Lyssiotis Lab

@LyssiotisLab

9 months

1,000,000 congrats!!! I don’t think we ( @Pasca_Lab ) could possibly be more proud of this guy 😊 cc: @UMPhysiology , @UMRogelCancer

Zeribe Nwosu

@zeribechike

9 months

I am excited to share that I have accepted the position of Assistant Professor (tenure-track) at Cornell University, @CornellMBG Ithaca, New York. Thank you Cornell for giving me the opportunity to pursue research at your esteemed institution.

163

104

1K

3

5

85

Lyssiotis Lab

@LyssiotisLab

7 months

Sending @zeribechike off in style 😎 Good luck in Ithaca @Cornell ! We can’t wait to hear about all the exciting discoveries from the **NWOSU LAB**! cc: @Pasca_Lab , @UMPhysiology , @UMRogelCancer , @UMICHpancreas

4

5

85

Lyssiotis Lab

@LyssiotisLab

2 years

🚨Job Posting: The @YatrikShahLab & @LyssiotisLab are looking for a postdoc to study the role of iron, O2, & metabolism in erythropoiesis. Opportunities to learn and employ multiple cutting-edge technologies in 2 ~pretty cool labs 😁 DM with interest.

2

51

83

Lyssiotis Lab

@LyssiotisLab

2 years

GOT2 consider the tumor microenvironment Thanks @BrianTDo1 , @mvh_lab , @trendscancer for highlight of our recent GOT2 in pancreatic cancer study! Fabulous job integrating, comparing/contrasting parallel work from @KivancBirsoy & @MaraShermanLab .

GOT2 consider the tumor microenvironment

To thrive in a hypoxic and nutrient-limited tumor microenvironment, pancreatic ductal adenocarcinoma (PDAC) cells rewire their metabolism. Understanding PDAC cell metabolism may uncover vulnerabili...

www.cell.com

2

12

83

Lyssiotis Lab

@LyssiotisLab

3 years

1/ Some exciting announcements about the 2021 #CancerMetabolism meeting at the @NYASciences . A thread 🧵 Please RT!

1

45

84

Lyssiotis Lab

@LyssiotisLab

4 years

This is nuts 👇 Flies can survive, and live a normal lifespan, with NO (none, zero) sleep if provided with gut-targeted antioxidants?! How can this be leveraged for man?

Sleep Loss Can Cause Death through Accumulation of Reactive Oxygen Species in the Gut

Sleep deprivation is associated with lethality through accumulation of reactive oxygen species in the gut.

www.cell.com

7

12

84

Lyssiotis Lab

@LyssiotisLab

2 years

Kicking off the @NYASciences #cancermetabolism2022 meeting with opening remarks from @lydfinley ! Disclaimer: I will be live-tweeting this event 🙌🏼😁

2

7

83

Lyssiotis Lab

@LyssiotisLab

4 years

1/ Excited to share the latest @biorxivpreprint from our group! Kudos to lead @UmichCancBio Grad Student Sam Kerk. Co-effort with @YatrikShahLab ; collaborative support from @Pasca_Lab , @HCCvPDAC , @HaoqiangY Labs. Please give it read. We welcome feedback (good, bad & ugly)!

bioRxiv

@biorxivpreprint

4 years

The Pancreatic Tumor Microenvironment Buffers Redox Imbalance Imposed by Disrupted Mitochondrial Metabolism #bioRxiv

0

4

15

2

19

79

Lyssiotis Lab

@LyssiotisLab

4 years

YES! Back-to-Back PhDs!! Please join us in congratulating **DOCTOR DANIEL KREMER** ( @DMKremer1 )! cc: @UMRogelCancer , @UMPhysiology , @UMICHpancreas

Lyssiotis Lab

@LyssiotisLab

4 years

Tomorrow (Thursday), 3PM EST Dan Kremer, @DMKremer1 "Metabolic Regulation of Ferroptosis in Pancreatic Cancer" @UMRogelCancer , @UMPhysiology , @UMichGIHep , @UMICHpancreas

2

3

24

9

7

81

Lyssiotis Lab

@LyssiotisLab

4 years

This @ScienceMagazine paper is absolutely bananas! Check out these images and videos. Dictostelium and pancreatic cancer cells navigating through mazes?! Wow! Mimics the decisions made during development and metastasis.

2

20

80

Lyssiotis Lab

@LyssiotisLab

1 year

📣 Symposium Announcement Please join us in Ann Arbor @UMich on May 25th for a 1-day meeting on “Metabolic and Immunological Impacts on Ferroptosis and Cell Death”. See the awesome speaker line-up below. Register for FREE at link: Please spread the word!

5

25

78

Lyssiotis Lab

@LyssiotisLab

15 days

Hey World, welcome the three newest @LyssiotisLab Ph.D. candidates 🙌🏼 Matt Perricone (Immunology), Gillian Davidson (CMB), and @julia_ugras (Cancer Biology) #rotatoes 🥔

0

4

80

Lyssiotis Lab

@LyssiotisLab

2 years

For our #Movemeber efforts, the dudes in the @LyssiotisLab received… *participation award 🏅*. Better luck next year, fellas 🤣 cc: @UMRogelCancer , @UMPhysiology , @UMICHpancreas

5

79

Lyssiotis Lab

@LyssiotisLab

3 years

We, @Pasca_Lab have a new story on @biorxivpreprint , which means, it’s #tweetorial time! First things first, 🎉BIG TIME CONGRATS🎉 to lead @zeribechike & thanks co-authors @HeatherGiza , @RosaMenjivar11 , @sam_kemp20 , @NinaSteele17 , et al.

Multi-dimensional analyses identify genes of high priority for pancreatic cancer research

Genomic profiling has unveiled the molecular subtypes and mutational landscape of pancreatic ductal adenocarcinoma (PDAC). However, there is a knowledge gap on the consistency of gene expression...

www.biorxiv.org

6

20

78

Lyssiotis Lab

@LyssiotisLab

4 years

1/ Thrilled to release our latest science on @biorxivpreprint ! This work is the culmination @LyssiotisLab graduate student @DMKremer1 PhD Thesis. "GOT1 Inhibition Primes Pancreatic Cancer for Ferroptosis through the Autophagic Release of Labile Iron"

4

19

76

Lyssiotis Lab

@LyssiotisLab

8 months

New video out from the @UMRogelCancer on cancer, metabolism and diet. Thoughts from @Lyssiotislab , @YatrikShahLab , @vennetilab with cameos from @radykm , @Sajjakulnukit , @HeatherGiza Link 👉🏼

5

21

75

Lyssiotis Lab

@LyssiotisLab

1 month

This is so cool. A gut-derived hormone regulates cholesterol metabolism:

A gut-derived hormone regulates cholesterol metabolism

Cholesin, a gut-secreted hormone induced by NPC1L1-mediated cholesterol uptake, binds to GPR146, inhibiting PKA-ERK1/2 signaling in the liver. This Cholesin-GPR146 axis suppresses SREBP2-controlled...

www.cell.com

0

18

75

Lyssiotis Lab

@LyssiotisLab

4 years

Sending our BIGGEST & most heartfelt congrats to an awesome colleague & kickass scientist, @Pasca_Lab , on her promotion to FULL PROFESSOR @umichmedicine , @UMichSurgery . Way to go, Marina! So very well deserved!! 🥂🍾🎉 cc: @UMRogelCancer , @UMICHpancreas , @HCCvPDAC , @Fil_Bednar

5

75

Lyssiotis Lab

@LyssiotisLab

3 years

Watch out cancer, these awesome #WomenInScience are coming for you 💪 #WomenInSTEM , @LyssiotisLab , @UMRogelCancer , @UMPhysiology , @umichmedicine , @UmichCancBio , @UMichImmunology

3

9

72

Lyssiotis Lab

@LyssiotisLab

8 months

Surprise visit to the @JasonRCantor Lab! Really awesome space in the @MorgridgeMeta Center. Oh, and good catching up with this old buddy too 😎

4

1

72

Lyssiotis Lab

@LyssiotisLab

3 years

Excited to share latest pub ( @jclinicalinvest ) & collaboration w/ #LombardLab ( @umichmedicine , @UMichPath )! Congrats Billy, et al.!! This tour de force covers a lot of territory, w/ numerous techniques & models, to demonstrate role of #SIRT5 in melanoma.

3

16

72

Lyssiotis Lab

@LyssiotisLab

4 years

1/ Kicking off 2020 with a #tweetorial covering ✌️ new #OpenAccess @LyssiotisLab papers on #GOT1 in #PancreaticCancer ! cc: @UMRogelCancer , @UMPhysiology , @michiganmedicine , @UmichCancBio

5

18

70

Lyssiotis Lab

@LyssiotisLab

6 months

📢Peer reviewers with expertise in all things cancer and metabolism wanted. Junior faculty and senior postdocs interested in peer review, in my new role at the journal Cancer & Metabolism, I am looking for you 🫵🏼! Reply or DM. Please RT and share widely 🙏🏼

@SN_Oncology

7 months

10 years of Cancer & Metabolism: Check out what has been published in Cancer & Metabolism over the past 10 years, and discover impactful research to inspire.

0

1

7

28

70

Lyssiotis Lab

@LyssiotisLab

1 year

Welcome to the 1st installment of pics with a Nobel Laureate #Kaelinfanclub #fangirl Seriously though, pleasure & honor to interact w/ Bill ( @kaelin_lab ) during @UMRogelCancer visit. Incredible seminar reviewing a remarkable career, yet still made time to wow us w/ new science!!

1

7

70

Lyssiotis Lab

@LyssiotisLab

5 years

Check out the @biorxivpreprint of our new study describing a method to couple the @Agilent #Seahorse metabolic flux assay with @BioTekTalk imaging of #mitochondrial content, fragmentation, membrane potential, and ROS. cc: @AndrewCLittle1 , @JoelYates , @VineePurohit , @sofiamerajver

bioRxiv

@biorxivpreprint

5 years

Integration of high-content fluorescence imaging into the metabolic flux assay reveals insights into mitochondrial properties and functions #bioRxiv

0

3

9

4

27

69

Lyssiotis Lab

@LyssiotisLab

9 months

Please join us in congratulating @UmichCancBio , @LyssiotisLab Graduate Student, Peter Kim, on a successful Defense! Congrats Dr. Kim 🙌🏼

3

5

70

Lyssiotis Lab

@LyssiotisLab

4 years

Out celebrating some recent successes with the @LyssiotisLab . Circled in red: K99/R00, @CJHPhD ; F31, Mengrou Shan; & F31, Sam Kerk. 🔥🔥🔥 This is absolutely the best group 😁 Thrilled and Proud to work with them all!! @UMRogelCancer , @UMPhysiology , @UMPDA1 , @UmichCancBio

2

68

Lyssiotis Lab

@LyssiotisLab

5 years

Tremendous honor to be selected @AmerGastroAssn Basic Science Young Investigator. I am humbled and extremely grateful to my mentors for nomination and support. Omary, Owyang, Carethers, @HCCvPDAC , @SantiagoSchnell . @UMPhysiology @UMichGIHep @UMRogelCancer

9

4

67

Lyssiotis Lab

@LyssiotisLab

1 year

Congrats Dr. Hanna Hong ( @_Hanna_Hong ) on earning your hood 🎉🥳 And it was not without incident. See blooper reel. Knocked off her cap, and then placed the hood backwards 🙃 Sorry Hanna! Thanks for bearing with me!

5

6

67

Lyssiotis Lab

@LyssiotisLab

3 years

I don't think I could possibly be more 🤩excited🤩 to co-host Lew ( @CantleyLab , @WCM_MeyerCancer ) with good friend Weiping Zou for @UMRogelCancer Grand Rounds. Tune in if you're at @umichmedicine , @UMich ! Outside the University, DM for Zoom link. 👉🏼 Monday, April 19 12PM EST.

1

10

66

Lyssiotis Lab

@LyssiotisLab

4 years

White Elephant gift exchange in the @LyssiotisLab . Shared quite a few laughs 😂 Best, worst gift: 30 pack of T.P. Best, best gift: well, see for yourself. Modeled by the boss.

3

1

66

Lyssiotis Lab

@LyssiotisLab

3 years

Dr. Zeribe Nwosu ( @zeribechike ) received the @UMPDA1 **Outstanding Postdoctoral Fellow Award** for his numerous efforts and achievements. Congrats Zeribe! Your mentors (cc: @Pasca_Lab , @LyssiotisLab ) and department (cc: @UMPhysiology , @UMRogelCancer ) are very proud of you 😁

5

6

66

Lyssiotis Lab

@LyssiotisLab

1 year

@YoungShull @mike_feigin

0

1

66

Lyssiotis Lab

@LyssiotisLab

7 months

1/ Science, food, & fun at the @LyssiotisLab retreat! [**] Seriously the best team 🥹 **cue Dad about to tell you he’s got the best kids

1

7

65

Lyssiotis Lab

@LyssiotisLab

1 year

Interested in pancreatic cancer, metabolism, and the tumor microenvironment? Want to spend your lunch hour on Zoom? Have we got the seminar for you 😁 TODAY, noon EST.

4

9

64

Lyssiotis Lab

@LyssiotisLab

1 month

Meet Dr. Sajjakulnukit 💪🏼👑

Lyssiotis Lab

@LyssiotisLab

2 months

Mark your calendars! It is going to be epic 💪🏼 Zoomers welcome. @Sajjakulnukit

0

7

26

5

4

63

Lyssiotis Lab

@LyssiotisLab

3 years

Looking forward to the virtual visit @StonyBrookMed ! *small update to title 😁

1

2

64

Lyssiotis Lab

@LyssiotisLab

1 year

So… been tasked with the tweetorial for @RosaMenjivar11 ’s new study in @eLife 😅 See below for link and 🧵 (1/x) Check it out 👇🏼

Rosa Menjivar, PhD

@RosaMenjivarPhD

1 year

So thrilled that my first first-author paper is out! 🥳🥳 Thanks to everyone that made this work possible: @Pasca_Lab @LyssiotisLab @zeribechike #WentingDu @KatelynLDonahue and the rest of the team! 💜💜💜

10

22

88

3

17

62

Lyssiotis Lab

@LyssiotisLab

2 years

Pleased to share a new review led by @J_Jimenez_A with @Lawlorlab on #aminoacid #metabolism in #bonesarcoma . It's #OpenAccess , please read and enjoy (link below)! cc: @UMPhysiology , @UMRogelCancer

3

17

64

Lyssiotis Lab

@LyssiotisLab

4 years

Love this cover art by my Greek brother, @ThalesPapaG . Also, awesome science. Holler!

Cell Metabolism

@Cell_Metabolism

4 years

NEW ISSUE!:

5

10

67

1

2

62

Lyssiotis Lab

@LyssiotisLab

3 years

We are TOP10! in the *world* for cancer research. Holla at all the awesome colleagues @UMRogelCancer making discoveries in the lab and clinic that are transforming cancer medicine. @Pasca_Lab , @YatrikShahLab , @DanWahlMD @vennetilab , @KoschmannLab , @castro2355_mg , […]

U-M Rogel Cancer Center

@UMRogelCancer

3 years

Did you know: U-M ranks No. 9 for oncology research among 1,500 institutions across the globe?

1

6

22

2

10

62

Lyssiotis Lab

@LyssiotisLab

2 years

Today, @J_Jimenez_A defends her PhD thesis! Send good vibes and congratulations!! @UmichCancBio , @UMPIBS , @UMRogelCancer , @Lawlorlab

1

4

62

Lyssiotis Lab

@LyssiotisLab

1 year

Say it with us: **Doctor** Hong! 🎉🎉 Congrats Hanna! Awesome defense to culminate an outstanding PhD.

5

4

62

Lyssiotis Lab

@LyssiotisLab

2 years

Look forward to co-hosting @KivancBirsoy tomorrow with @YatrikShahLab for the @UMPhysiology Seminar Series!

1

8

62

Lyssiotis Lab

@LyssiotisLab

2 years

Nothing warms my heart more than seeing a mentee be a mentor. @HeatherGiza working with Hadeer, a @UMPhysiology summer undergraduate fellow. 💪🏼😊 cc: @UMRogelCancer

1

3

61

Lyssiotis Lab

@LyssiotisLab

2 years

Interested in diet & cancer? See recent #Viewpoint on work from Rabinowitz lab. Study illustrates how ketone bodies (result of #keto diet) increase tumor reductive stress & enhance chemotherapy in #PancreaticCancer . Clinical trial launched to test in man.

Anirban Maitra

@Aiims1742

2 years

From Josh Rabinowitz @Princeton (collaboration with @salk @TGen ): Preclinical studies demonstrate that ketogenic diet & chemotherapy combine to disrupt #PancreaticCancer metabolism & growth. #ClinicalTrial testing this premise:

2

21

60

2

22

61

Lyssiotis Lab

@LyssiotisLab

5 years

Excited to share a formal version of our metabolomics protocols in @NatureProtocols for isotope tracing in cancer. Long-standing collaboration spearheaded by the #Asara group; critical input and support from: @Manning_BD @bensahralab

0

15

61

Lyssiotis Lab

@LyssiotisLab

1 year

Love this write-up on @UMichCMB grad student, @BrandonTWChen . C. Bidlack captures the essence of our relationship w/ telling quotes: “Talking to Costas is good, I always get a lot of good ideas from him,” Brandon comments. “Do you?” Costas interjects. They both burst out laughing

1

4

58

Lyssiotis Lab

@LyssiotisLab

3 years

⚠️ Attention Junior Faculty & Senior Postdocs ⚠️ The 2021 meeting on #CancerMetabolism @NYASciences will feature 🌟 Rising Stars 🌟 Outside of the Keynote, all talks will be selected from the nomination pool (see link). Please retweet & spread the word!

0

42

60

Lyssiotis Lab

@LyssiotisLab

11 months

Appreciate the opportunity from @MolecularCell to hype exciting new work on #PancreaticCancer #Metabolism from the @nada_kalaany Lab 🙌 Written with @AwadDom . Check it out 👇

1

17

60

Lyssiotis Lab

@LyssiotisLab

4 years

For the love. How is this word pronounced? HOECHST

16

1

59

Lyssiotis Lab

@LyssiotisLab

11 months

Hangin out w/ Cis Maisel, “mother” of @UMRogelCancer & namesake of my endowed professorship (Maisel Research Professor of Oncology). Cis is a joy & inspiration. Thanks for your support of @UMRogelCancer , @UMICHpancreas & @LyssiotisLab 🙏🏼 Also pic’d: Dr Max Wicha, former Director

0

1

58

Lyssiotis Lab

@LyssiotisLab

1 year

Metabolic enzymes (PKM2, PGK, etc.) did *not* exhibit S/T kinase activity in this profiling effort. Not only did they not have preferred motifs, they quite literally had no kinase activity. cc: @MarcusDGon , @lydfinley , @mvh_lab ,

Cantley Lab

@CantleyLab

1 year

We are delighted to share our work, now available in @Nature : Our scoring system can be accessed here: Coming soon --> the tyrosine kinome and an improved system with many new functionalities & features! #TheKinaseLibrary #KL

12

329

1K

1

7

57

Lyssiotis Lab

@LyssiotisLab

2 years

Heather ( @HeatherGiza ) sharing her exciting ideas on #Ferroptosis at the @CSHANews meeting in Japan. She has so much data, that she need to maximize the poster board space! 🔄9️⃣0️⃣ @UMRogelCancer @UmichCancBio

3

58