New pre-print! In our latest study, we show that #MLL3 acts as a tumor suppressor in #LiverCancer by co-activating the #CDKN2A locus. Hence, MLL3 mutation/loss is a new mechanism for disrupting CDKN2A activity during cancer development. . Tweet added by Lowe Lab @LoweLabMSKCC

Lowe Lab

2 years

New pre-print! In our latest study, we show that #MLL3 acts as a tumor suppressor in #LiverCancer by co-activating the #CDKN2A locus. Hence, MLL3 mutation/loss is a new mechanism for disrupting CDKN2A activity during cancer development. .

MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer

Mutations in genes encoding components of chromatin modifying and remodeling complexes are among the most frequently observed somatic events in human cancers. For example, missense and nonsense...

www.biorxiv.org

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Lowe Lab

@LoweLabMSKCC

2 years

Congratulations to co-first authors Yadira Soto-Feliciano, @ChangyuZhu1 & @JohnPMorrisIV , co-corresponding author @Tschaharganeh , and many thanks to our fantastic collaborators David Allis, @Armstrong_DFCI , @RichardKoche & everyone else who contributed!