Nature - A non-canonical tricarboxylic acid cycle is required for changes in cell state.

Nature - A study of patients with breast cancer and mouse models demonstrates that most circulating tumour cells are generated during the rest phase of the circadian rhythm, and that these cells...

The field of cancer metabolism provides us with a framework to understand basic cellular metabolic principles and pathways.

Nature Cell Biology - Baksh et al. show that oncogenic epidermal stem cells require extracellular serine to initiate squamous cell carcinoma via altering dioxygenases that remove H3K27me3.

Nature - Variable expression of an enzyme is an early step in tumour spread.

Cells acquire essential nutrients from the environment and utilize adaptive mechanisms to survive when nutrients are scarce. How nutrients are traf...

Mammalian pre-implantation development is associated with striking metabolic robustness, as embryos can develop in a wide variety of nutrient conditions including even the complete absence of soluble...

Nature - Rapid activation of protein synthesis in the axolotl highlights the unanticipated impact of a translatome on orchestrating the early steps of wound healing and provides a missing link in...

Nature Metabolism - The transition from senior postdoc to early-stage investigator is a pivotal step in the careers of academic scientists. In this series, early-stage investigators reflect on...

Nature - A newly identified exercise-induced signalling metabolite—an amidated conjugate of lactate and phenylalanine—can reduce food intake and improve blood glucose homeostasis.

Transferred mitochondria do not always regulate cell behavior by simply restoring mitochondrial function, but rather, transferred mitochondria are dysfunctional, initiating downstream signaling and...

Fumarate siphons electrons to keep metabolism running

Amino acid limitation triggers preferential uncharging of glutamine-specific tRNAs and depletes polyglutamine tract-containing proteins from mammalian cells, revealing a potential role for polyglut...

Nature - A population of β-cell-specific autoimmune stem-like CD8 T cells initiates and sustains β-cell destruction and disease in a mouse model of type 1 diabetes.

This article presents a personal and critical review of the history of the malate–aspartate shuttle (MAS), starting in 1962 and ending in 2020. The MAS was initially proposed as a route for the...

Nature Cell Biology - Finley et al. show that Brd4 is dispensable for self-renewal and pluripotency in murine embryonic stem cells (ESCs). In metastable ESCs, Brd4 independence can be achieved by...

Participants have the opportunity to perform hands-on research in cutting-edge biomedical research laboratories.

Nature - A chemical reaction network that overlaps with the biological Krebs and glyoxylate cycles arises from pyruvate and glyoxylate in the presence of iron, suggesting how early metabolic...

The quantitative characteristics of [U-14C]glutamate transport were determined in rotenone-inhibited energized rat kidney mitochondria at pH 7.0 and 28 degrees C. Glutamate efflux was observed to be...

Preimplantation mouse embryos interact minimally with their environment, and development is largely driven by metabolic processes. During the earliest cleavage stages, metabolism is rigid, with...

Single-particle cryo-EM structures of CLC-7 in the presence and absence of its β-subunit, OSTM1, reveal insights into transporter regulation.