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Molecular Cell

@MolecularCell

13 days

Our latest issue is now out:

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Molecular Cell

@MolecularCell

10 months

Online Now: Transcription factors interact with RNA to regulate genes

Transcription factors interact with RNA to regulate genes

Oksuz et al. provide evidence that transcription factors frequently bind RNA at active loci, doing so with a conserved domain resembling the arginine-rich motif of the HIV Tat protein. TF-RNA binding...

www.cell.com

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Molecular Cell

@MolecularCell

6 months

Online Now: Lactate activates the mitochondrial electron transport chain independently of its metabolism

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Molecular Cell

@MolecularCell

1 year

De-centralizing the Central Dogma: mRNA translation in space and time

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Molecular Cell

@MolecularCell

9 months

Transcription factors interact with RNA to regulate genes

Oksuz et al. provide evidence that transcription factors frequently bind RNA at active loci, doing so with a conserved domain resembling the arginine-rich motif of the HIV Tat protein. TF-RNA binding...

www.cell.com

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Molecular Cell

@MolecularCell

2 years

Our latest issue is out today!

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Molecular Cell

@MolecularCell

6 months

Lactate activates the mitochondrial electron transport chain independently of its metabolism

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Molecular Cell

@MolecularCell

3 years

Viral pores are everywhere

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Molecular Cell

@MolecularCell

2 years

Read our latest issue:

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Molecular Cell

@MolecularCell

1 year

The latest issue is out today

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Molecular Cell

@MolecularCell

4 months

The biochemical pathways of apoptotic, necroptotic, pyroptotic, and ferroptotic cell death

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Molecular Cell

@MolecularCell

5 months

Online Now: m6A modification negatively regulates translation by switching mRNA from polysome to P-body via IGF2BP3

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Molecular Cell

@MolecularCell

1 year

Our #mitochondria focus issue is out today, featuring review articles centered on the diverse cellular processes involving mitochondria and the approaches used to study them.

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Molecular Cell

@MolecularCell

4 months

Our special issue on “stress” features review articles on how cells sense and respond to stresses. We also invite scientists to discuss common stressors in research and publishing

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Molecular Cell

@MolecularCell

1 year

Read our latest issue:

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Molecular Cell

@MolecularCell

3 years

Lipid metabolism in sickness and in health: Emerging regulators of lipotoxicity

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Molecular Cell

@MolecularCell

1 month

Our latest issue is out today:

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Molecular Cell

@MolecularCell

2 months

Online Now: Denaturing purifications demonstrate that PRC2 and other widely reported chromatin proteins do not appear to bind directly to RNA in vivo

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Molecular Cell

@MolecularCell

4 months

Online Now: Chromatin gene-gene loops support the cross-regulation of genes with related function

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Molecular Cell

@MolecularCell

4 months

m6A modification negatively regulates translation by switching mRNA from polysome to P-body via IGF2BP3

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Molecular Cell

@MolecularCell

2 years

Coping with starvation: Cysteine keeps mTORC1 suppressed to ensure survival

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Molecular Cell

@MolecularCell

6 months

Online Now: Stress, epigenetics, and aging: Unraveling the intricate crosstalk

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Molecular Cell

@MolecularCell

2 years

CRISPR-based genome editing through the lens of DNA repair

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Molecular Cell

@MolecularCell

9 months

Read our latest issue here

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Molecular Cell

@MolecularCell

3 months

Our latest issue is online now:

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Molecular Cell

@MolecularCell

1 year

Online Now: De-centralizing the Central Dogma: mRNA translation in space and time

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Molecular Cell

@MolecularCell

4 months

Stress, epigenetics, and aging: Unraveling the intricate crosstalk

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Molecular Cell

@MolecularCell

4 years

The Ongoing Quest to Crack the Genetic Code for Protein Production

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Molecular Cell

@MolecularCell

23 days

Online Now: Time-resolved profiling of RNA binding proteins throughout the mRNA life cycle

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Molecular Cell

@MolecularCell

2 months

Online Now: Transcription factor exchange enables prolonged transcriptional bursts

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Molecular Cell

@MolecularCell

3 years

A time to build and a time to burn: glucose metabolism for every season

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Molecular Cell

@MolecularCell

8 months

Read our latest issue here:

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Molecular Cell

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4 months

DNA damage and transcription stress

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Molecular Cell

@MolecularCell

4 months

Online Now: Collisions of RNA polymerases behind the replication fork promote alternative RNA splicing in newly replicated chromatin

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Molecular Cell

@MolecularCell

1 year

In this special issue of Molecular Cell, we explore the universe of the Central Dogma with reviews, perspectives and interviews addressing how genetic information is transferred within the cell and open questions for future research. Read it here:

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Molecular Cell

@MolecularCell

2 years

The CRISPR-Cas toolbox and gene editing technologies

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Molecular Cell

@MolecularCell

2 years

A high-resolution map of human RNA translation

Chothani et al. evaluate ribosome-mRNA interactions across six cell types and five tissues and reveal 7,767 small regions outside of the protein-coding genome that are actively translated in humans....

www.cell.com

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Molecular Cell

@MolecularCell

3 years

RNA reports breaking news from mitochondria

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Molecular Cell

@MolecularCell

4 months

High-throughput PRIME-editing screens identify functional DNA variants in the human genome

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Molecular Cell

@MolecularCell

3 months

FOXA1 forms biomolecular condensates that unpack condensed chromatin to function as a pioneer factor

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Molecular Cell

@MolecularCell

2 years

Online Now: Protein degradation on the global scale

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Molecular Cell

@MolecularCell

5 months

Online Now: FOXA1 forms biomolecular condensates that unpack condensed chromatin to function as a pioneer factor

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Molecular Cell

@MolecularCell

3 months

Online Now: CAG repeat expansions create splicing acceptor sites and produce aberrant repeat-containing RNAs

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Molecular Cell

@MolecularCell

2 years

Read our latest issue:

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Molecular Cell

@MolecularCell

2 years

Life of RISC: Formation, action, and degradation of RNA-induced silencing complex

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Molecular Cell

@MolecularCell

1 month

Transcription factor exchange enables prolonged transcriptional bursts

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Molecular Cell

@MolecularCell

2 months

Chromatin gene-gene loops support the cross-regulation of genes with related function

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Molecular Cell

@MolecularCell

4 years

Amplifying the Noise: Oncometabolites Mask an Epigenetic Signal of DNA Damage

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Molecular Cell

@MolecularCell

6 months

Human histone H1 variants impact splicing outcome by controlling RNA polymerase II elongation

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Molecular Cell

@MolecularCell

3 months

Out with the old, in with the new: Pioneer transcription factors as activators and repressors of lineage specification genes

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Molecular Cell

@MolecularCell

2 years

Online Now: The CRISPR-Cas toolbox and gene editing technologies

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Molecular Cell

@MolecularCell

3 months

CAG repeat expansions create splicing acceptor sites and produce aberrant repeat-containing RNAs

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Molecular Cell

@MolecularCell

2 years

Online Now: HiCAR is a robust and sensitive method to analyze open-chromatin-associated genome organization

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Molecular Cell

@MolecularCell

4 months

Online Now: Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma

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Molecular Cell

@MolecularCell

3 years

Discovering the landscape of protein modifications

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Molecular Cell

@MolecularCell

27 days

Read the latest issue here:

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Molecular Cell

@MolecularCell

8 months

Online Now: Mitochondrial degradation: Mitophagy and beyond

Mitochondrial degradation: Mitophagy and beyond

Mitochondria play many important roles in cellular homeostasis, ranging from metabolic regulation to cell signaling. When mitochondria no longer meet cellular needs, they are degraded or removed. In...

www.cell.com

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Molecular Cell

@MolecularCell

4 years

Online Now: ATAC-Me Captures Prolonged DNA Methylation of Dynamic Chromatin Accessibility Loci during Cell Fate Transitions

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Molecular Cell

@MolecularCell

4 years

Online Now: Intrinsically Disordered Regions Direct Transcription Factor In Vivo Binding Specificity

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Molecular Cell

@MolecularCell

2 years

ATACing single cells with phages

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Molecular Cell

@MolecularCell

9 months

FACS-based genome-wide CRISPR screens define key regulators of DNA damage signaling pathways

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Molecular Cell

@MolecularCell

1 year

Online Now: Ubiquitin-independent proteasomal degradation driven by C-degron pathways

Ubiquitin-independent proteasomal degradation driven by C-degron pathways

While the proteasomal degradation of most eukaryotic proteins is thought to be dependent on ubiquitin, Makaros et al. systematically investigated the requirements and mechanisms underlying protein...

www.cell.com

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Molecular Cell

@MolecularCell

2 years

Circular RNA migration in agarose gel electrophoresis

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Molecular Cell

@MolecularCell

2 years

Read the latest issue

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Molecular Cell

@MolecularCell

2 months

Online Now: A programmable targeted protein-degradation platform for versatile applications in mammalian cells and mice

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Molecular Cell

@MolecularCell

9 months

mRNA stability and m6A are major determinants of subcellular mRNA localization in neurons

Loedige et al. revise the existing mRNA localization model, demonstrating that a high mRNA half-life in neurons reliably predicts localization to neurites. This mechanism appears essential for...

www.cell.com

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Molecular Cell

@MolecularCell

7 months

Online Now: DICER ribonuclease removes harmful R-loops

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Molecular Cell

@MolecularCell

6 months

DNA damage induces nuclear envelope rupture through ATR-mediated phosphorylation of lamin A/C

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Molecular Cell

@MolecularCell

3 months

Online Now: Specialized replication mechanisms maintain genome stability at human centromeres

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Molecular Cell

@MolecularCell

3 years

Online Now: Proteome-wide mapping of short-lived proteins in human cells

Proteome-wide mapping of short-lived proteins in human cells

Li et al. identified 1,017 short-lived proteins under translational arrest among over 11,000 quantified proteins in four human cell lines. This study provides a large-scale resource of human short-...

www.cell.com

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Molecular Cell

@MolecularCell

2 years

Chromatin as a metabolic organelle: Integrating the cellular flow of carbon with gene expression

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Molecular Cell

@MolecularCell

10 months

Online Now: Spatial and temporal organization of the genome: Current state and future aims of the 4D nucleome project

Spatial and temporal organization of the genome: Current state and future aims of the 4D nucleome...

The 4D nucleome project aims to develop an understanding of how the genome works and is regulated through analysis of its dynamic spatial organization. Dekker et al. summarize progress made by the...

www.cell.com

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Molecular Cell

@MolecularCell

2 years

Read the latest issue

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Molecular Cell

@MolecularCell

2 years

Online Now: Circular RNA migration in agarose gel electrophoresis

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Molecular Cell

@MolecularCell

2 months

Online Now: Enhancer-promoter interactions are reconfigured through the formation of long-range multiway hubs as mouse ES cells exit pluripotency

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Molecular Cell

@MolecularCell

1 month

Online Now: eIF4F is a thermo-sensing regulatory node in the translational heat shock response

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Molecular Cell

@MolecularCell

4 months

Subcytoplasmic location of translation controls protein output

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Molecular Cell

@MolecularCell

9 months

Online Now: mRNA location and translation rate determine protein targeting to dual destinations

mRNA location and translation rate determine protein targeting to dual destinations

Protein targeting between destinations can be modulated post-translationally. Using NET1 as a model, Gasparski et al. show that, additionally, mRNA location in the cytoplasm and its translation...

www.cell.com

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Molecular Cell

@MolecularCell

7 months

Our latest issue is a Focus on Genome Stability. Read more here:

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Molecular Cell

@MolecularCell

2 years

Are nanopore technologies ready for the proteomic challenge primetime?

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Molecular Cell

@MolecularCell

1 month

Online Now: Nucleolar stress caused by arginine-rich peptides triggers a ribosomopathy and accelerates aging in mice

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Molecular Cell

@MolecularCell

4 months

Online Now: Dual regulation of SLC25A39 by AFG3L2 and iron controls mitochondrial glutathione homeostasis

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Molecular Cell

@MolecularCell

1 year

Mitochondrial pores at the crossroad between cell death and inflammatory signaling

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Molecular Cell

@MolecularCell

5 months

Online Now: DNA damage and transcription stress

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Molecular Cell

@MolecularCell

11 months

Structure of the human ATP synthase

Lai et al. determine the complete structures of human ATP synthase in three main rotational states and one substate, providing mechanistic insights into the structure and function of the ATP synthase...

www.cell.com

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Molecular Cell

@MolecularCell

11 days

Nucleolar stress caused by arginine-rich peptides triggers a ribosomopathy and accelerates aging in mice

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Molecular Cell

@MolecularCell

4 years

DNA Damage and Cancer Immunotherapy: A STING in the Tale

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Molecular Cell

@MolecularCell

4 months

Online Now: The competitive landscape of the dsRNA world

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Molecular Cell

@MolecularCell

3 years

Our metabolism focus issue is online now!

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Molecular Cell

@MolecularCell

3 years

Online Now: Recent technical advances in the study of nucleic acid modifications

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Molecular Cell

@MolecularCell

2 months

Online Now: Structural atlas of human primary microRNAs generated by SHAPE-MaP

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Molecular Cell

@MolecularCell

22 days

Online Now: An RNA-dependent and phase-separated active subnuclear compartment safeguards repressive chromatin domains

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Molecular Cell

@MolecularCell

11 months

Online Now: Histone H3 lysine 27 crotonylation mediates gene transcriptional repression in chromatin

Histone H3 lysine 27 crotonylation mediates gene transcriptional repression in chromatin

Nan et al. demonstrate that GAS41 through its YEAST domain recognizes histone H3 lysine 27 (H3K27) crotonylation and is recruited by proto-oncogenic MYC to SIN3A-HDAC1 co-repressors to repress gene...

www.cell.com

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Molecular Cell

@MolecularCell

2 months

Online Now: The proteomic landscape of genotoxic stress-induced micronuclei