Nature - Metabolomics analysis of the mouse embryo shows a metabolic shift towards the tricarboxylic acid cycle between gestational days 10.5 and 11.5, leading to the subsequent development of...

Nature - The lactylation of lysine residues on histones in mammalian cells is stimulated by hypoxia and bacterial challenges, and increased histone lactylation induces genes involved in wound healing.

Intra-operative 13C-glucose infusions are safe and informative in pediatric cancer patients, with metabolite labeling revealing glycolysis, glucose oxidation, and pyruvate dehydrogenase and pyruvate...

Nature Immunology - How the mitochondrial electron transport chain (ETC) interacts with the NLRP3 inflammasome is somewhat unclear. Here the authors use individual complex inhibitors and new...

Intermediary metabolism in cancer cells is regulated by diverse cell-autonomous processes including signal transduction and gene expression patterns arising from specific oncogenotypes and cell...

Nature Metabolism - We are approaching the 100th anniversary of Otto Warburg’s first description of the metabolic phenotype bearing his name—a propensity for tumours to metabolize...

The electron transport chain in cancer cells contributes to 13C labeling in vivo.

Nature Medicine - Systematic metabolite profiling across cancer cell lines uncovers patterns associated with genetic and epigenetic features and reveals dysregulated metabolic states that can be...

Learn how these investigators' projects aim to break new ground in biomedical, behavioral, and clinical cancer research.

Cellular metabolism regulates immune cell activation, differentiation and effector functions to the extent that its perturbation can augment immune responses. However, the analytical technologies...

Nature - Oxidation of ubiquinol by the mitochondrial electron transfer chain drives tumour growth by maintaining the function of the oxidative Krebs cycle and de novo pyrimidine synthesis.

Haig Kazazian Jr., M.D., a pioneering scientist in the field of genetic medicine, died Jan. 19 of congestive heart failure. He was 84 and a resident of Bal

Nature - Differences in MCT1 function among melanoma cells confer differences in oxidative stress resistance and metastatic potential.

Nature Biotechnology - Intracellular redox defects are treated with an extracellular chimeric enzyme.

Now in its 12th year, the Lurie Prize in Biomedical Sciences recognizes outstanding achievement by promising scientists aged 52 or younger. The prize includes a $100,000 honorarium for the awardee,...

Nature - Melanoma cells undergo less oxidative stress and less ferroptosis in lymph than in blood, owing to higher levels of oleic acid in lymph, and thus exposure to the lymphatic environment...

Nature Chemical Biology - Identification of an improved glucose-6-phosphate dehydrogenase (G6PD) inhibitor G6PDi-1 blocks G6PD activity more robustly than the widely cited antagonist DHEA. G6PDi-1...

Ni et al. investigate human LIPT1 deficiency, which results in developmental delay, epilepsy, and broad metabolic abnormalities, including lactic acidosis, L- and D-2-hydroxyglutaric aciduria,...

The pentose phosphate pathway is a major source of NADPH for oxidative stress resistance in cancer cells but there is limited insight into its role...