Subhojit Roy, MD, PhD @Roy_Lab_Thinks Twitter profile

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Subhojit Roy, MD, PhD

5 months

Massive 10+ year effort in lab spearheaded by @leonardoaparrar and Kayal (secret account 🤔). Unreal cover by @EmmaVIDALL that says it all.

Neuron

@NeuroCellPress

5 months

2023's final issue is out! Cover story is from @Roy_Lab_Thinks 's lab revealing an unexpected physiologic role for α-synuclein phosphorylation in clustering synaptic vesicles and restricting neurotransmitter release. Read it here

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

1 year

So...Jury duty selection last week: - Judge: "What do you do?" - Me: "Science." - J: "What kind of Science?" - Me: "Why thanks for asking...let's start with slow axonal transport, a mysterious way soluble proteins are conveyed down the axon...." - Judge: "Thank you you can go."

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

3 years

Biology is messy. Your advisor/mentor knows that. Show them everything, they know that's the way this gig works. And if they want perfect results every time, consider leaving.

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

3 years

Cells you transfected with GFP last night:

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

2 years

Cell biologists looking at Systems Neuroscience

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

5 years

Am I the only one saying NO SCALE BAR

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

1 year

An email is not a doorbell. I'll send it whenever I like, you read it whenever you like.

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

2 years

Presenting the Midwestern Blot:

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

3 years

Greybeard #NIH grant reviewer here. Most Specific Aims pages only make sense after reading the rest of the grant. The Aims page needs to stand alone and make sense. All info that reader needs to understand that page needs to be ON THAT PAGE. Yes, It's not easy.

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

4 years

Does anyone else spend 67 hours making a figure and 105 hours admiring it?

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

2 years

Surprised how so many don't ask these 3 questions BEFORE starting experiment: 1) What's the expected result? <helps see if it happens> 2) What are all the possible results? <helps design controls> 3) What will I do with expected/possible results? <helps design future exps>

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

3 years

My lab will be hiring at all levels soon - postdocs, senior scientists, technicians. Please send your CV if interested (). Projects centered around gene therapies in neurodegeneration, particularly Parkinson's disease. Please RT.

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

7 months

"Just walk up and say hello" is advise I see for young scientists at meetings. Let me tell y'all I've been saying hello for >20 years and I've been snubbed almost every time. Happens even now if people don't know me from my name. Sciencing while brown?

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

1 year

No protein translation allowed in Idaho anymore.

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

3 years

Clathrin is one of the most studied proteins. But what if I said you don't even know where it is in a neuron? "Get the hell out?" See our paper @NeuroCellPress Co-first @ganguly_archan @Rohantific ; collab w/ 1 and only @christlet , mass-spec guru @JohnRYatesIII and others.🧵

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

3 years

We did a paper for journal club today (glossy journal). Good until Fig. 2 but then instead of mechanism, all RNA-seq/massively parallel stuff. Much easier to throw $$ and get guaranteed data, than figure out actual mechanism. Everyone was dazzled. Highly recommend approach.

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

5 months

I wonder who looks at Boston and says "Hey I really wanna spend next 5 years here". As opposed to....say San Diego. I mean just look at sample aerial shots I took recently. Unrelated, I am looking for a senior lab manager and postdoc. At #cellbio2023 , let's talk if interested.

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

3 years

The 2021 award for making website changes that no one wanted goes to "era Commons"! Congratulations from the 2020 winner, Pubmed.

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

2 years

@zillowgonewild nope

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

4 years

One of the biggest mistakes funding agencies make is to prioritize projects that can "lead to a therapy", without first investing in ideas that look at the basic biology. In the end everyone has to circle back, but this wastes decades. Case in point #Alzheimers 1/3

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

4 years

I can't believe that just 2 min later - at 10:55 to be precise - he picked up a completely different paper on CRISPR-therapeutics

Prof. Shane Crotty

@profshanecrotty

4 years

A Congressman asked Tony Fauci a question about T cells, and Fauci reached down and picked up our paper and waved it! COVID testimony today. I should make business cards with that screenshot. 😂doi:10.1016/j.cell.2020.05.015 @CellCellPress @SetteLab

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

2 months

An important part of staying grounded in #academia is not to fall into the 'celebrity trap'. No one has any obligation to recognize anything you have done. Take joy in finding new things, and be happy someone pays you a salary for just doing that.

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

3 years

OK fine. Glia are important.

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

5 years

Well meaninged but funny: Person next at dinner: "Who's lab do you work in?" Me: "Roy lab" Person across: "Hey do you know how to pronounce his first name?" "Yes. Yes I do"

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

6 months

👀👀

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

6 months

I didn't believe this for the longest time but it really seems that neurotransmission requires a puff of local protein synthesis at presynapses. What's the need with all the proteins already there, supplied by axonal transport? What proteins? Fun to think:

Synapse-specific burst coding sustained by local axonal translation

Axons extend far from neuronal cell bodies yet need stable protein supply. Although many proteins are locally synthesized in mature axons, their functional roles are unclear. Wong et al. reveal how...

www.cell.com

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

1 year

"The hypercompetitive academic environment offers a survival benefit for people with personality traits such as boldness, dominance, meanness and disinhibition." Rudeness is often seen as genius in #academia !

How bullying becomes a career tool

Nature Human Behaviour - How bullying becomes a career tool

www.nature.com

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

3 years

Ha. Looks like we have a new paper. Gene therapy is the future, so please see this review.

TweetALS

@TweetALSMND

3 years

#FYI @NatureNeuro Gene-based therapies for neurodegenerative diseases #GeneTherapy @Roy_Lab_Thinks

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

3 years

Word that only academics use: "substantive" More? #AcademicChatter

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

3 years

Parents got all dressed up for the vaccine 😂

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

5 years

Three things needed in Aims page of any grant application: 1. Current state of knowledge 2. Gap in knowledge 3. How you will fill up the Gap No need to make it complicated.

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

3 years

...this is how it works. You do first experiment expecting perfect result. ITS A MESS. Next 20 times - also a mess. Pondering on this mess, glimmer of insight. Follow that, find new things. It will be nothing like you started. But if you don't share everything, everyone loses.

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

1 year

@BrielmaierL Yeah I was just warming up...felt like my constitutional right for explaining the Science was taken away.

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

5 years

Announcement: The Roy lab is moving to @UCSDHealth @UCSDNeuro over the summer/fall, and we have open postdoctoral (x2) and technician (x1) positions. Check out our interests at . PS: I know y'all have questions but for now please RT.

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

5 years

Tip for grant applications: Look at your hypothesis and look at your aims. Are your experiments really testing your hypothesis? They must. Are they the BEST POSSIBLE experiments to test your hypothesis? If not, why not? You will need to address this.

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

2 years

Didn't realize this needs to be told but if you are showing a figure from someone's paper in your talk, show the citation on the slide. Especially if the author is part of your audience.

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

1 year

For each slide, write down and ponder these 3 things: 1) Why am I showing THIS slide? 2) What is the ONE take home point? 3) How will I TRANSITION to next slide? Many miss #3 . 90% of a good #presentation is the thinking behind the scenes. I know because I've given many bad ones

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

5 years

Finally....R01 renewed, collaboration with @christlet

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

5 years

So we used CRISPRs to inactivate the amyloid pathway in Alzheimer's disease. Collaboration with @sahakris @pamjmclean and non-tweeps. Here's the back story 1/n

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

5 years

Not a single thing is correct here. Which is hard to do

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

2 years

The real opening scene of a #science breakthrough is not someone running around naked yelling "Eureka!", but a deeply frustrated person lamenting that the carefully acquired data makes no sense at all.

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

4 years

My story @CellMentor if you want a break from crazy news, features @christlet and others:

There is no right career path: A perspective from an immigrant physician-scientist

Making the best of any available opportunity is what immigrants have been doing for centuries. Subhojit Roy from UCSD shares his experience doing just that.

crosstalk.cell.com

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

6 years

Looks like immunostaining, but its a stable neuroglioma cell line expressing a single copy of GFP-tau, using a genetic trick. Why? Because we can.

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

4 years

10 min 😮

Florian Witulski

@vaitor

4 years

Korea finished developing the 10 minute Covid-19 diagnostic kit and is now ramping up production. They plan to export 300.000 test-kits per week -

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

5 years

There is a misconception amongst postdocs that CNS papers are a must for getting faculty positions. Not true. NOT. TRUE. A publication record methodically addressing important questions is key.

Harmit S. Malik

@HarmitMalik

5 years

@Zhu_Lab @yamashitaflylab @TanentzapfLab @STCmicrobeblog It’d be nice to have a dataset not based on interviewed faculty candidates at just a few ‘elite’ places. For example 4 postdocs from my lab in last 10 years got multiple job offers, prestigious awards & federal grants without CNS papers at any stage cc: @JSheltzer

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

4 years

postdocs please do not use the P200 this way

Ian Goodfellow

@igoodfel

4 years

Watching Maze Runner 3 - science in films is always fun. Stop ramming that p200 in her arm and she may stop screaming.

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

5 years

Three key "what's" in a grant application: 1) What is the burning question? 2) What do you have that's so special? 3) What will you do? If you don't have 1) and 2), having 3) is no use.

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

3 years

Sorry but "I love Science" is not enough to be a good scientist. Understanding and enjoying the scientific process, ridiculous patience, and ability to find joy in absurdly small discoveries is way more important.

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

2 years

THIS is where @christlet got all our data. I always imagined a much bigger microscope.. #Marseille

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

5 years

What's the normal function of alpha-synuclein (a-syn, key protein involved in #Parkinsonsdisease ). Our paper in this issue @PNASNews . It was quite a science journey spanning almost a decade (1/n):

Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling | Proceedings of the...

The function of α-synuclein (α-syn) has been long debated, and two seemingly divergent views have emerged. In one, α-syn binds to VAMP2, acting as ...

www.pnas.org

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

4 years

My teenage son bought a $15 scale from Amazon that is as accurate as the $1500 lab-scale from VWR. Head to head comparison.

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

3 years

So many bad figure legends. PLEASE: 1) Imagine a guy who has NEVER seen the fig before saying "What am I lookin' at?". Explain. 2) For caption, say what your interpretation is, not vague generalizations. "Earth goes around Sun". Not "Analysis of the movement of Earth and Sun".

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

6 years

Gold dust

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

3 years

Kayal found this weirdo EM thingy in our neuronal cultures. Can anyone ID? @christlet

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

9 months

OK then, our paper @eLife . Conceived by @DanielGitler & transcontinental collab. Lead authors @SashaStavsky & @leonardoaparrar . Thanks to anon reviewers ("highly relevant" "elegant"). Previously, we showed synapsin binds alpha-synuclein and is necessary for a-syn function.🧵1/10

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

5 years

@ryanaboyd The whole 'fantastic beasts' thing is garbage. Book, movie...all of it.

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

3 years

...every scientist likes to talk about the time when the first experiment work. They are lying.

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

2 years

My god @HarmitMalik is micromanipulating the whole of @fredhutch

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

5 years

Bump into famous scientist at meeting. "I came by train so I could work the whole time, what about you?". "I came early yesterday and watched Star Trek on the hotel TV all day. I don't have cable at home!". Pregnant pause. Conversation ends

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

3 years

Someone asked me what was the one common thing amongst my most successful trainees and I hadn't thought of it before but the answer was easy. They all worked the hardest. Sorry Twitter. I'll delete my account now.

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

4 years

"No reviewer has ever said that a paper was too easy to read". Excellent writing tips:

Scientific writing 101

Nature Structural & Molecular Biology - Less is more when it comes to writing a good scientific paper. Tell a story in clear, simple language and keep in mind the importance of the 'big...

www.nature.com

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

5 years

Science is not supposed to be easy. Because its about creating new knowledge. And creating new knowledge in any field is hard. Very hard.

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

1 year

Phosphorylation of alpha-synuclein at Ser-129 is a pathologic hallmark of Parkinson's+. Normally, only ~ 4% is Ser129P, so almost all studies have focused on pathology. Surprisingly, we found that Ser129P has a role in normal a-syn function: 🧵👇1/8

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

4 years

"My room (in college) had a lamp, and I was thankful every night that I had light to study under—something I have learned to never take for granted"

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

5 years

Lets talk figure legends ('cos too many bad ones) 1) Start with caption summarizing what you think is going on 2) For each panel, begin with WHAT YOU DID ("Cells were incubated with....stained for...") 3) Finally, point to things & tell me what I'm looking at IN THIS SEQUENCE.

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

3 years

I can't believe no one saw this so I made a figure. They need some scientists at #INDvAUS Tim Paine #DRS #Cricket

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

5 years

So someone asked me yet again, what to do as a #NewP with all the "new responsibilities". Answer the same: FOCUS ON THE FIRST PAPER FROM YOUR LAB. IGNORE EVERYTHING ELSE. Good night.

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

3 years

Now that's a nice surprise. Thanks @NatureNeuro

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

3 years

Two synapses body-slamming a dendrite with a bystander mitochondria fuming the flames. Pic by Kayal (not on Twitter, apparently)

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

2 years

One of the best books I've read....

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

3 years

Please don't say "cells" when you mean "neurons". Thank you for not arguing.

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

2 years

Early on as PI, I gave a talk where the entire faculty kept piling on how data I was showing "would never be good for an R01". Came back to hotel and checked, none of them had an active R01. Checked just now and they still don't. I've had several since then.

katie

@focusfronting

2 years

what’s your (anonymized!) conference presentation horror story, mine was when someone gave a talk and then in the q&a it was immediately pointed out that what they thought was interesting was just a spelling convention and the whole paper was based on a misunderstanding

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

4 years

"Giving a great talk may come naturally to some, but most folks need repeated practice and coaching. Everything from having clear, well-labeled slides to learning how to tell a good story requires practice."

On being an advisor to today’s junior scientists | Proceedings of the National Academy of Sciences

On being an advisor to today’s junior scientists

www.pnas.org

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

10 months

"Above all, students must be shown the scientific process as it is — with its limitations and potential pitfalls as well as its fun side, such as serendipitous discoveries and hilarious blunders."

Train PhD students to be thinkers not just specialists

Nature - Many doctoral curricula aim to produce narrowly focused researchers rather than critical thinkers. That can and must change, says Gundula Bosch.

www.nature.com

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

1 year

Sometimes you wonder....is there a message here?

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

3 years

Anyone knows who should be credited for this pic showing relative size of cell body v/s axon? I've heard Peter Hollenbeck but don't have a reference (tried @christlet and reverse-Google already).

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

5 years

No one will tell you this but if you want your paper to be read in @biorxivpreprint you have to format it like a real paper with figures and legends weaved into text. It's not that hard to do.

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

3 years

Neuron! Stay tuned.

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

7 years

When choosing grad school mentor, choose grad school mentor. Not the project, fellow students, postdocs, jovial environment, lab décor etc.

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

3 years

Nothing good ever comes out of email starting with - "Thank you for your application...."

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

2 years

3rd thing people look at in a paper are figures (after title & abstract). They look at images/graphs & try to guess what the hell you're saying. Reading fig legend is step 4. MANY STOP AT 3. Help people get from 3->4. Your figs must tell a story. No, captions are not optional.

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

3 years

The first thing you need to know about cloning is that you don't need to know. Just do it again. And again. And again. It will work.

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

3 years

A Google for protein structure. Just input your favorite protein. Crazy.

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

3 years

Me: "Do you want me to bring bagels to the lab tomorrow?" Postdoc: "What I really want is your car."

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

2 years

Ok these guys know beer #synucleinmeeting2022 #Leuven

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

4 years

Imagine having your paper rejected and then seeing the three reviewers, editors and entire journal staff deliriously dancing on the streets throughout the night. Hrrrr. #AcademicChatter

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

1 year

Some synaptic vesicles in this synapse seem to have an identity crisis...has anyone seen anything like this? @clathrin ? [Pic by Kayal Madhivanan]

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

3 years

..highly annoying thing in reviews - even very recently - is "yah this is nice but...is it good for journal xx <insert fav glossy jrnl>". Sir Reviewer, your job is see if its TRUE and if its NEW. Then you go home. No one knows what stands test of time. Certainly not jrnl name.

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

5 years

I'm tired of this CNS s**t folks. Just do the goddamn science, publish papers that people actually want to read, and everything else will fall in place. If you don't believe in my $0.02, fine. Find your own way. Don't @ or DM me.

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

5 years

My postdoc mentor! Virginia taught me how to see and pick out the best next steps for any given project.

ScienceofParkinsons

@ScienceofPD

5 years

Congratulations to Prof Virginia Man-Yee Lee @Penn @PennPathLabMed for being awarded one of the 2020 Breakthrough Prize in Life Sciences for her work on neurodegenerative conditions like #ALS , #Alzheimers & #Parkinsons

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

1 year

Big Brent gave an awesome talk today on using #CRISPR for #Alzheimers but believes that people think he's here to do the drywall. Have never done this but hit like if you think everyone belongs in #science (I want to show Brent this tweet).

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

2 years

New baby in lab alert. Asked my postdoc @Rohantific for data today and this is what I got:

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

2 years

Gate agent: "Refusal to wear a mask may lead to removal from the plane at any time during the journey...". ANY time?!

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

5 years

"Go back to your country!" "OK, remember to feed my postdocs. Raise minimum half a million every year. Bye."

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

3 years

Twitter, what's the latest greatest fluorophore for endogenous tagging? I heard mNeon but that was before the pandemic. @christlet

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

3 years

We have a postdoctoral position starting immediately, to work on gene therapies in neurodegeneration. Please RT

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

4 years

. @NIHDirector needs to make a statement on where @NIH stands on this. Silence = Approval

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

4 years

Single cells become multicellular to walk away and find food. What

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Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

3 years

There is only one correct answer to who invented CRISPR-Cas. Bacteria.

5

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64

Subhojit Roy, MD, PhD

@Roy_Lab_Thinks

2 years

Real thread on giving a 10 min talk. It's quite tough but here are three tips: 1) You can only talk about a SINGLE story. Don't even try. You're gonna lose them. The guy saying "thank you for the wonderfully detailed talk" is lying. Trust me. 1/3

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