Sabatini and Tian review recent progress in developing genetically encoded neurotransmitter indicators. They also discuss practical considerations for both sensor developers and end users in terms of...

Christopher Walsh studies how the human brain develops with an appreciation for how basic science is informed and enriched by patients. In this interview, Dr. Walsh shares how mapping a genetic...

Neurons can release multiple neurotransmitters. Are they packaged in segregated pools of vesicles or within the same ones? In this issue of Neuron, Kim et al., 2022, examined features of GABA-gluta...

Are current diversity, equity, and inclusion initiatives addressing systemic issues? This article highlights the progress thus far and emphasizes the systemic and cultural shifts needed to support...

Blood-tumor barrier (BTB) and tumor cell quiescence are two major obstacles in brain cancer treatment. Chen, Momin, and Wanggou et al. show that mechanosensitive tumor cells construct the BTB....

Halassa and Sherman highlight the role of the thalamus in cortical function and the lack of knowledge surrounding thalamocortical connectivity at single-cell resolution. They propose thalamocortical...

Mashour et al. review more than two decades of research on the global neuronal workspace theory of conscious processing; examine recent data related to unconscious states; and present a synthesis...

Replays of place cell sequences in the hippocampus are thought to underlie memory consolidation for spatial learning. In this issue of Neuron, Mou et al. show that not only self-running but also...

Ginosar et al. review recent evidence from rodents and bats, arguing against the classic hypothesis that grid cells provide a global metric for space. They propose three alternative hypotheses, with...

Experience-dependent de novo myelination may fine-tune activated circuits by promoting brain synchrony, important for memory consolidation. Steadman et al. find that blocking this form of adaptive...

How does the brain process natural versus drug rewards? Alhadeff et al. demonstrate that food and drugs signal from the periphery to the hypothalamus via distinct pathways. Furthermore, bidirectional...

Li et al. generate high-resolution single-cell transcriptomes of microglia and related myeloid cells across mouse brain regions and developmental stages. They show limited heterogeneity of adult...

For more information, see VanRyzin et al., Neuron 102/2, http://www.cell.com/neuron/fulltext/S0896-6273(19)30115-1.Immune brain cells called microglia engulf...

Transcriptomic and functional changes in glia are hallmarks of Alzheimer’s disease. In this issue of Neuron, Sadick, O'Dea, et al. define transcriptomic differences in astrocytes and oligodendrocytes...

Hennig et al. consider learning in the brain through the lens of optimization, a powerful framework for training artificial networks. They identify three aspects of how neural population activity...

Predictive coding and neural oscillations are two descriptive levels of brain functioning whose overlap is not yet understood. Chao et al. (2018) now show that hierarchical predictive coding is...

In this issue of Neuron, Vikbladh et al. (2019) provide evidence to suggest that the human hippocampus, long known to support spatial memory, also plays a causal role in model-based planning.

Autophagy is crucial for nervous system function. However, its physiological substrates are largely unknown. Kuijpers et al. demonstrate, using knockout mice conditionally lacking the essential...

The previous decade has seen a rapid increase in microglial studies on pain, with a unique focus on microgliosis in the spinal cord after nerve injury and neuropathic pain. Numerous signaling...

Readhead et al. construct multiscale networks of the late-onset Alzheimer’s disease (AD)-associated virome and observe pathogenic regulation of molecular, clinical, and neuropathological networks by...

For more information, see Sosa et al., Neuron, https://www.cell.com/neuron/fulltext/S0896-6273(19)31008-6.Using simultaneous multi-region recordings in rats,...

Divakaruni et al. showed that LTP induction prompts dendritic mitochondrial fission and mitochondrial Ca2+ transients (mCaTs), delineated a novel mechanism of activity-dependent fission regulation in...

The brain mechanisms by which exercise improves mood remain unclear. Zhang et al. dissect a hypothalamo-cerebello-amygdalar circuit bridging the subcortical motor and limbic systems, through which...