Nature Neuroscience - The authors used single-cell genomics to profile thousands of human dopamine neurons and identify one uniquely Parkinson’s disease-susceptible population, which was...

Nature Neuroscience - The authors derive a neural network theory of systems consolidation to assess why some memories consolidate more than others. They propose that brains regulate consolidation...

Nature Neuroscience - Maimon et al. demonstrate a therapeutically viable approach, single-dose injection of a DNA drug to suppress synthesis of PTB, to generate new neurons in the aged mouse...

Nature Neuroscience - The authors establish a connection between functional subtypes and genetic subtypes of dopamine neurons in mice and demonstrate that molecular expression patterns can serve as...

Nature Neuroscience - Benzodiazepines, used to treat anxiety and sleep disorders, may cause cognitive impairment. Shi et al. demonstrate that this is caused by interaction with the mitochondrial...

Nature Neuroscience - The authors derive a local plasticity model that shapes neuronal representations to predict future sensory inputs. The same model accounts for fundamental neural plasticity...

Nature Neuroscience - A novel study led by scientists in Lübeck, Germany, shows that SARS-CoV-2-infected brain endothelial cells undergo cell death due to the cleavage of NEMO by the viral...

Nature Neuroscience - When people are isolated, they crave social interactions. Midbrain craving regions were activated by food in hungry people, and by social interactions in people mandated to be...

Nature Neuroscience - The authors reconstructed the individual projectomes of 6,357 mouse prefrontal cortical projection neurons, revealing projectome-defined neuron subtypes and organizing...

Nature Neuroscience - Effective science communication is necessary for engaging the public in scientific discourse and ensuring equitable access to knowledge. Training doctoral students in science...

Nature Neuroscience - In primates, activity in the visual cortex is not driven by spontaneous body movements. These results confirm the functional specialization of primate visual processing, in...

Nature Neuroscience - How do multiple synapses interact to modulate learning? Agnes and Vogels postulate models of ‘co-dependent’ synaptic plasticity that promote rapid, multi-synaptic...

Nature Neuroscience - Moliner et al. show that psychedelics directly bind to the BDNF receptor TrkB with high affinity and promote BDNF-mediated plasticity and antidepressant-like effects, whereas...

Nature Neuroscience - The authors present a circuit tracing method, Trans-Seq, which determines the targets of a given neuron type through anterograde tracing combined with single-cell RNA...

Nature Neuroscience - Two fMRI studies (n = 358) show that cognitive regulation of negative emotion alters cortical activity but not amygdala or other subcortical areas....

Some groups of neurons process sensory data and memories at the same time. New work shows how the brain pivots those representations to prevent interference.

Nature Neuroscience - A new brain mapping approach tailored to individual people reveals that volume changes in psychiatric illness occur in highly variable locations across individuals, but that...

Nature Neuroscience - The brain perceives and adapts to stressors via multiple interacting molecular mechanisms involving the cell surface, cytoskeleton and epigenetic regulation resulting in...

Nature Neuroscience - Brain region-specific oligodendrocyte population dynamics are unclear. Here the authors implement long-term in vivo three-photon imaging to determine those dynamics in the...

Nature Neuroscience - Using in vivo imaging in zebrafish, Li and colleagues found that neuron–oligodendrocyte precursor cell (OPC) synapses regulate OPC development and myelination via Ca2+...

Nature Neuroscience - The authors found that the expression of spatial maps in the hippocampus is modulated by the internal state of an animal. Thus, the brain’s code for spatial positions...

Nature Neuroscience - Combining brain imaging, genetics and behavioral data, this study shows that distinct brainwide distributions of serotonin receptors explain the known division of serotonin...

Nature Neuroscience - Monosynaptic cerebellar projections to the substantia nigra pars compacta (SNc) increase the activity of SNc neurons and striatal dopamine levels. These projections may convey...

Nature Neuroscience - By reconstructing the complete dendrites and axons for nearly 2,000 neurons in PFC, Gao et al. comprehensively classified dendrite morphology, revealed the relationship...

Nature Neuroscience - Samborska et al. trained mice on a set of problems with the same structure but different physical layouts to study generalization. Neurons in prefrontal cortex generalized...

Nature Neuroscience - Eze et al. use single-cell sequencing and immunohistochemical validation to create an atlas of early human brain development. In the telencephalon, they discover a diversity...

Nature Neuroscience - fMRI reveals similar topography, selectivity and inter-connectedness of language brain areas across 45 languages. These properties may allow the language system to handle the...

Nature Neuroscience - Aging is associated with the formation of focal white matter lesions and atrophy. The authors discovered a role for CD8+ T cells in driving white matter-specific interferon...

Nature Neuroscience - Recent progress in astrocyte biology requires a more cohesive conceptual framework. This Perspective introduces a ‘contextual guidance’ paradigm in which...

Nature Neuroscience - Single-cell genomics reveal that Alzheimer’s dementia involves the complex interplay of virtually every major brain cell type. Cell-type-specific molecular perturbations...

Nature Neuroscience - The primary somatosensory cortex and central nucleus of the amygdala project to the spleen via the dorsal motor nucleus of the vagus nerve and regulate the T helper 2 (TH2)...

Nature Neuroscience - Perl et al. show that in PTSD, hippocampal representations of autobiographical memories are similar across people with similar semantic content only for sad but not traumatic...

Nature Neuroscience - Hong et al. show that activation of the medial prefrontal cortex induces REM sleep via its projections to the lateral hypothalamus, thus demonstrating a critical role of the...