Jennifer Kwan MD PhD Profile
Jennifer Kwan MD PhD

@jennkwanMDPhD

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Physician scientist, cardiologist @Yale , working on translational research in cardio-onc, imaging, genomics & CV effects and mechanisms of somatic variants/CHIP

Joined October 2009
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@jennkwanMDPhD
Jennifer Kwan MD PhD
2 years
Interested in grad school/MD PhD training? Pursuing a senior research project? We work on somatic variants/Clonal hematopoiesis and their effects on cardiovascular health @YaleMed . Join us! #genomics #bioinformatics #stemcells #cardioonc #hearttissue
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@jennkwanMDPhD
Jennifer Kwan MD PhD
2 years
Behind the scenes w/Olympic Gold🥇Medalist @nathanwchen : So fun to learn ice skating from him!
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@jennkwanMDPhD
Jennifer Kwan MD PhD
2 years
Great to👂from physician scientists/scientists on cutting edge work they do to tackle cardiovascular disease & cancer w/S Campbell, @BraunMDPhD , @david_van_dijk : glad➡️work w/ @nathanwchen in the @jennkwanMDPhD lab. Look forward➡️inspiring biomedical research video w/ @nathanwchen
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@jennkwanMDPhD
Jennifer Kwan MD PhD
2 years
Excited about @nathanwchen 's interest in a career in medicine . . . and biomedical research?! He will do great things! @janiceschen #physicianscientist
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@jennkwanMDPhD
Jennifer Kwan MD PhD
1 year
Mingling w/ @NIH directors, Nobel laureates, deans/chairs, medical/scientific leaders @JointMeeting to hear about & discuss cutting edge research to improve human health w/a rising ⭐️ w/ @nathanwchen #physicianscientists @KnowingAlok
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Jennifer Kwan MD PhD
11 months
@Olympics 🥇medalist @nathanwchen explores a day in the life of physician scientists, highlighting the importance of supporting their work to improve human health. Glad to hear of his interest in this career. Congrats on winning an @AHAScience award! #Genomics QC🧬🫀 health #linux
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@jennkwanMDPhD
Jennifer Kwan MD PhD
11 months
Thx  @davidrliu for hosting us  @primemedicine ; great to meet CEO Keith Gottesdiener, CSO Jeremy Duffield & the leadership team to hear about your journeys, ongoing exciting therapeutic targets & future vision for #geneediting . Thx for invite to  @primemedicine party! @nathanwchen
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@jennkwanMDPhD
Jennifer Kwan MD PhD
2 months
Congrats @nathanwchen & team for your work identifying #CHIP as a novel risk factor for #ICImyocarditis #ACC24 . Biomarker features/Pathways to be presented @AACR by Rachel Jaber Chehayeb #AACR24 Interdisciplinary cases in #cardioonc #cardio -heme @Milesshen8 @MohaK92 #DivyaIyer
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@jennkwanMDPhD
Jennifer Kwan MD PhD
6 months
Deep learning #CNN #dynamicimaging to predict #CHIP & future cardiomyopathy from CMR  @AHAScience @American_Heart Scientific sessions w/ @Cross_JL & @nathanwchen @david_van_dijk @E_Zappala
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@jennkwanMDPhD
Jennifer Kwan MD PhD
6 months
@nathanwchen presenting his novel partition/risk distribution scores for elucidation of #CHIP , new CHIP-like variants that impact #HF outcomes & associated pathways involved w/the Kwan lab, @knowingalok @reillylikesit @Cross_JL @American_Heart @AHAScience #deeplearning #genomics
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Jennifer Kwan MD PhD
10 months
@davidrliu lab: where #geneediting magic happens;  @nathanwchen works w/ @IPWitte : transfects cells w/ #CRISPR , ABE, CBE or #Primeeditor to edit🧬target➡️seq prep➡️ @illumina seq➡️readout efficiency of gene edits w/ @alvinhsu0 ;⬆️to 70% base editing efficiency w/BE evolved from PACE!
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Jennifer Kwan MD PhD
2 years
Thx to cutting edge @Yale genome core for giving us a tour of your state of the art facilities/talking about genomics research/accomplishments, role in the precision health initiative @YaleGenetics ; a candy store of🧬sequencing @illumina @PacBio @nanopore #robotics @nathanwchen
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Jennifer Kwan MD PhD
1 year
Supporting Jeacy Espinoza in the Kwan lab on his #computerscience senior research project #CHIP #singlecells w/ @nathanwchen @KnowingAlok @YaleCVRC @YaleCompsci
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Jennifer Kwan MD PhD
1 month
Great to catch up w/friend/colleague @NCIDirector @KimrynRathmell @AACR #AACR24 to hear about exciting initiatives @theNCI , her support of early career physician-scientists & ways we can work w/ @AJIAorg , our new nonprofit w/ @EvanNoch dedicated to early career investigators
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Jennifer Kwan MD PhD
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@Nathanwchen presents our work showing #CHIP = independent risk factor for #ICImyocarditis ! Great to have awesome friends/colleagues come by! @ruey_hu @sarajdiaz1   #ACC24 @Yale @YaleCardiology #cardioonc Come by our work @AACR today for insights on pathways involved! #AI #ML
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Jennifer Kwan MD PhD
1 year
Great to hear from @ashishkjha & his experience w/advising the @WhiteHouse on the COVID19 pandemic & importance of science communication w/ @nathanwchen @KnowingAlok
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Jennifer Kwan MD PhD
3 months
@Cross_JL presents our work @YaleMed #AI in #Medicine symposium, leveraging  #LLM to extract #CMR report features, showing high concordance w/human expert annotation #highthroughput @david_van_dijk @nathanwchen @YaleCVRC @YaleCardiology @Yale
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Jennifer Kwan MD PhD
2 years
What's Olympian gold🥇medalist @nathanwchen 's next move? Look forward➡️working w/him to communicate the importance of biomedical research🧬🧪to improve human health & hear about his career goals in Medicine🩺💊🏥! @janiceschen #Nathanchen #jurrassicparksci
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Jennifer Kwan MD PhD
6 months
@ASHG ? Swing by our poster PB4443: Development and evaluation of a #genomics pipeline to evaluate somatic mitochondrial variants in health & cardiovascular disease states. #ASHG23 #mitochondrialsomaticvariants w/ @KnowingAlok @nathanwchen #Kishanpatel
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Jennifer Kwan MD PhD
1 year
Hanging out w/all ⭐️speakers to lay out current state of affairs & what we need do to train & retain physician scientists @nathanwchen @MaryEKlotman @NIDDKgov @YaleMed @YaleIMed @WeillCornell @NorthwesternMed
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@jennkwanMDPhD
Jennifer Kwan MD PhD
11 months
So great to see @nathanwchen in action @starsonice in Boston! What a talented ice skating ⛸ crew! @Olympics #champion #worldchampions #SOI23
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Jennifer Kwan MD PhD
9 months
Thanks Aneesh.agrawal, @justin_spired et al for hosting us @instagram , w/>2 billion person reach, glad to hear of efforts to tackle misinformation! Addressing science & medical misinformation is crucial for well being of society!  @peterhotez @EricTopol ; @nathanwchen mtg w/fans!
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Jennifer Kwan MD PhD
10 months
So inspiring to meet  @SammyBasso & @Progeria research team including Dr Leslie Gordon & Dr Collins @NIH to see the potential of #geneediting to improve the plight of progeria patients & beyond. Exciting work toward clinical trials! Thx for having us in the discussion @davidrliu !
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@davidrliu
David R. Liu
10 months
Be inspired in 15 minutes: @SammyBasso , the world's oldest living progeria patient, explains how he maintains such a positive life philosophy, working with us every week to advance a gene editing treatment towards the clinic. Video: @BrilliantMindsSthlm
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Jennifer Kwan MD PhD
3 months
@TODAYshow
TODAY
3 months
. @teamusa @USFigureSkating has won figure skating gold nearly two years after the Beijing Olympics due to a doping scandal that disqualified a Russian skater. The team adds that they "would love" to have an official medal ceremony at the Paris Olympics!
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Jennifer Kwan MD PhD
11 months
Taking a mini sabbatical w/ @nathanwchen @knowingalok to work w/ #baseediting #primeediting , guru,  @davidrliu @HHMInews , @broadinstitute @MIT @Harvard . Inspired by all the patients he has helped w/his #geneediting tools to tackle #genetic diseases. Thx for hosting us! @IPWitte
@davidrliu
David R. Liu
11 months
Happy to host Yale undergraduate science major (and reigning Olympic figure skating champion / 3x world champion) @nathanwchen & Professor @jennkwanMDPhD in our lab for a week of experiments, data analysis, and outreach activities. Thank you @IPWitte for showing Nathan the ropes.
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Jennifer Kwan MD PhD
1 month
Great to catch up with friends @illumina and always inspiring to review the innovation wall of patents! Thx Jason for the mtg & tour! @nathanwchen @KnowingAlok
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Jennifer Kwan MD PhD
9 months
Thanks @aametwally1 for hosting us  @Google ; proud of all you have accomplished! Look forward to collaborations!
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Jennifer Kwan MD PhD
2 years
So great to meet the new dean of @yaledatascience , physician scientist Lucila Ohno Machado @UCSDHealth & her vision for data science initiatives @Yale & how it is an exciting time for #datascience given large diverse cohorts like @AllofUsResearch @YaleData
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Jennifer Kwan MD PhD
1 month
@YaleMed student Rachel Jaber Chehayeb presents our work: using explainable AI/ML to id top cytokine features and pathways of pts w/ #ICImyocarditis & immunosuppression resistant ICImyocarditis #JAKStat pathway is a top pathway @YaleCardiology @YaleCancer @YaleMed #cardioonc
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Jennifer Kwan MD PhD
9 months
Thank you  @janiceschen for hosting us @mammothbio , impressive to see your growth over the past few yrs! Great to catch up with @martintrevor_ & meet @CRISPR_LuCas !
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Jennifer Kwan MD PhD
9 months
A week of learning, connecting & building w/ @nathanwchen @KnowingAlok in SF bay area. Great to catch up w/friends  @aametwally1   @tejaswini @jackpo   @janiceschen  & mtg new ones! Thx @tejaswini for showing us your iPOP & space studies & @SnyderShot for inviting us to your party!
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Jennifer Kwan MD PhD
9 months
Thanks  @GrailBio leadership for reviewing your pioneering #galleri test that can detect up to 50 cancers early, impressed w/low false (+) rate/high PPV compared to traditional cancer screening; look forward to seeing your clinical trial results! @JeffreyVenstrom @tinaclarkedur
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Jennifer Kwan MD PhD
4 years
Applying for a @NIH K award? Want guidance/tips from a leader in career development who has been invited to give grant writing workshops around the country? Join us for @A_P_S_A 's K grant writing session on Sat 7/25/20, 1pm-230pm EST #physicianscientist
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Jennifer Kwan MD PhD
1 month
@ritujith shares our work characterizing the treatment course of immunosuppression resistant #icimyocarditis pts (made up >50% of ici myocarditis pts) @AACR ; outcomes analysis in the works #AACR24 @AACRFoundation #cardioonc @YaleCardiology @YaleCancer
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Jennifer Kwan MD PhD
9 months
Thanks Charlotte for hosting us  @meta /facebook, & thanks to @p_barbera , Monica Bhole, @michaelcbailey for reviewing their research, including the impact of SoMe on the 2020 elections and socioeconomic connection insights w/ @nathanwchen @KnowingAlok
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@jennkwanMDPhD
Jennifer Kwan MD PhD
8 months
@JAMA_current study of 39k+ investigators in clinical depts #physicianscientists , over 10 yr period shows that @NIH research funding gaps are the norm, not the exception, w/average gaps of 2-3 yrs ➡️Implications for tenure/need for bridging
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@jennkwanMDPhD
Jennifer Kwan MD PhD
1 year
Addressing #Climatechange , an important cause @nathanwchen , @naomiosaka , @MichaelPhelps ! Also has health implications: ♥️ CVD, 🫁 asthma, 🦠 infectious disease, climate change refugees . . .
@PanasonicNA
Panasonic North America
1 year
At Panasonic, the well-being of our planet is our top priority. As we officially kick off our #GREENIMPACT initiative alongside @naomiosaka , @nathanwchen , and @m_phelps00 , we’re striving for a greener, healthier, more equitable future. More at #CES2023 .
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Jennifer Kwan MD PhD
1 year
Congrats @sarahaboualaiwi @BrighamWomens & incoming @YaleCardiology fellow, for pulling together these multi-center studies to shed light on effect of ICIs on patients w/🫀metastases & primary cardiac tumors! #cardioonc @ACCinTouch #ACC23 #physicianscientist
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Jennifer Kwan MD PhD
2 years
Skip brass @PennMedicine getting @A_P_S_A founders award: data on funding $ sources of physician scientists who stayed in research careers, majority had non @NIH funding ➡️ lessons learned
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@jennkwanMDPhD
Jennifer Kwan MD PhD
9 months
Interested in unraveling the role of somatic variants/CHIP in cardiovascular disease 🫀/aging using genomics🧬/imaging? The Kwan lab, co-mentored with Dr Alok Jha has an opening for a postdoctoral fellow: Info and how to apply:  #bigdata #genomics #AI #ML
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Jennifer Kwan MD PhD
2 years
In @AcadMedJournal today: Assessing impact of #COVID19 on phy scientist trainees👩‍⚕️to faculty🩺during the initial peak of the pandemic showed ⬆️high stress, impaired productivity. F/u survey 1.5 yrs out shows both stress & impaired productivity🚫improved.
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@jennkwanMDPhD
Jennifer Kwan MD PhD
2 years
Grateful➡️friends, colleagues, mentors @YaleCardiology for several great yrs as a fellow @CardioOnc_MR_CT @edwardmiller #cardioonc #cMRI #CardiacCT Look forward➡️adventures running my own lab #datascience #CHIP #somaticvariants #imaging as faculty @YaleCardiology @ericjvelazquez
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@jennkwanMDPhD
Jennifer Kwan MD PhD
1 year
What are chairs looking for in hiring phys sci/How can we retain them? Excited:🌟lineup w/ @MaryEKlotman   @DukeMedSchool Gary Desir MD, chair  @YaleIMed   @YaleMed Elizabeth Ross MD PhD @WeillCornell Griffin Rodgers, @NIDDKgov director  @EdwardSchaeffer   @NM_Urology @NorthwesternMed
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@jennkwanMDPhD
Jennifer Kwan MD PhD
2 years
Pandemic has amplified challenges for ♀️/URM in medicine. Join us for this all 🌟line up @jointmeeting to hear about current data & actions taken/good practices to address disparities & retain talent! w/ @HeartBobH @arghavan_salles @StanfordDeptMed & Diana Lautenberger @AAMCtoday
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@jennkwanMDPhD
Jennifer Kwan MD PhD
2 years
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@jennkwanMDPhD
Jennifer Kwan MD PhD
2 years
Multitalented @janiceschen ! Also look forward to your talk about exciting #geneediting 🧬projects/initiatives @mammothbiosci @JointMeeting
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@jennkwanMDPhD
Jennifer Kwan MD PhD
2 years
Majority of $ for #physicianscientists in academia come from non @NIH funds per @AAMCtoday MD PhD program outcomes study; hear about opportunities & approaches to obtaining non NIH funding (as we advocate to⬆️ @NIH $). Join us on June 9, 2-3pm EST
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@jennkwanMDPhD
Jennifer Kwan MD PhD
4 years
Immunology-Metabolism-Cardiology Interface: depletion of cardiac macrophages ➡️LV dysfunction in 🐭❤️
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@VirusesImmunity
Prof. Akiko Iwasaki
4 years
Cardiomyocytes release subcellular particles called exophers that transport defective mitochondria for elimination by macrophages 🤯 Cardiac muscle cells outsource mitophagy to neighboring macrophages. Division of labor. Efficiency. @AndrsHidalgo16
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Jennifer Kwan MD PhD
3 years
Friends asking about #pregnancy & #COVID19 vaccine: Useful guidelines from @acog & @MySMFM  shared w/me by MFM physician-scientist extraordinaire @yafshar , who contributed to this Q&A  @UCLA   @chrissyfarr
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@jennkwanMDPhD
Jennifer Kwan MD PhD
3 years
What's the impact of #COVID19 on #physicianscientists ? What can we do to help retain them? Hear from thought leaders on what is being done/what can be done. Speakers:  @NIHDirector @NIH @LouisMuglia @BWFUND   @clairepomeroy @LaskerFDN @A_P_S_A Join us:
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Jennifer Kwan MD PhD
3 years
@YaleCardiology representing @NCYIForum #NCYIF21 : The future of cardiology research is bright. Congrats @rohan_khera @ekoikonomou on your 1st place awards!🏆 @Yale @YaleMed #physicianscientists . Thx @bonowr & all leadership for leading/hosting/mentoring!
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Jennifer Kwan MD PhD
4 years
As @A_P_S_A policy chair, we invited  #RBG to discuss the importance of policy, gender equality in science/medicine; although her schedule did not permit, her work continues to inspire us to advocate for a more just society. We thank her for her efforts in life & on the court!
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Jennifer Kwan MD PhD
2 years
Excited our  @American_Heart abstract was accepted for oral presentation #AHAscientificsessions . + #AT1R autoantibodies➡️need for⬆️immunosuppression in immune checkpoint inhibitor myocarditis pts #immunotherapy #cardioonc   @CardioOnc_MR_CT
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Jennifer Kwan MD PhD
2 years
Great job @AeronSmallMD on shedding light on #aorticstenosis outcomes via a novel #PRS 🧬 using MVP, TIMI, @uk_biobank data! @pnatarajanmd #bigdata
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Jennifer Kwan MD PhD
3 years
Look forward to representing @YaleCardiology & sharing work on Clonal Hematopoiesis of Indeterminate Potential ( #CHIP ) in #cardiooncology patients & its effects on myocardial function #bioengineering #genetics #imaging #immunology @Halene_lab @YaleMed
@NCYIForum
NCYIF
3 years
Invited Basic Science Fellows for #NCYIF21 🔬
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Jennifer Kwan MD PhD
3 years
Thank you science &  @kkariko for her pioneering work on mRNA therapies, paving the way to the #COVID19 vaccine; thx to @YNHH @YaleMed for this shot!
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Jennifer Kwan MD PhD
2 years
Ben Ebert @DanaFarber reviews CHIP, a proinflammatory state⬆️🫀disease risk. CHIP⬆️w/age; sequencing technique🔼prevalence. DNMT3a=♀️ biased, other CHIP mutations=♂️ biased. Chemo⬆️CHIP risk #CardioOnc What about CHIP in #cardioonc patients? Join me @ @ACCinTouch 22
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@jennkwanMDPhD
Jennifer Kwan MD PhD
2 years
#Baseediting advances in treating disease w/ @davidrliu , single shot💉w/potential➡️⬇️CV risk for a lifetime w/ @skathire , #geneediting for diagnostics/therapeutics w/ @janiceschen & insights from a US defense/security expert for potential areas of misuse/bioterror; must-see session!
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Jennifer Kwan MD PhD
2 months
What does the management of immunosuppression resistant #ICImyocarditis look like? One of the rising @YaleIMed @YaleMed chief IM residents, Ritu Jayakrishnan, will take us through their courses; outcomes are in the works.
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Jennifer Kwan MD PhD
1 year
One of the best parts of #ACC23 : catching up with friends/colleagues & cheering on eachother's work! @rohan_khera @ruey_hu . Thx to @ericjvelazquez for bringing together the all star ⭐️ @YaleCardiology crew!  @RitzCarlton @ACCinTouch
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@jennkwanMDPhD
Jennifer Kwan MD PhD
2 years
Reverse #cardioonc w/ @rudolf_deboer +stress test⬆️risk of cancer mortality, HF⬆️tumor growth, independent of hemodynamic effects in🐭. Mech: shared risk factors for cancer & HF, cardiokines #CardioOnc @ACCinTouch ➡️classification for cardio onc syndromes
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@jennkwanMDPhD
Jennifer Kwan MD PhD
3 years
Thx also @PeterHotez & @hmkyale for being a #physicianscientist role models/advocates & @thehill for raising visibility on these important issues @DrEJBMD
@PeterHotez
Prof Peter Hotez MD PhD
3 years
To prepare for future pandemics we must support physician-scientists | ⁦ @thehill ⁩ many thanks ⁦ @jennkwanMDPhD ⁩ ⁦ @DrEJBMD ⁩ for the nice mention
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Jennifer Kwan MD PhD
1 year
@pnatarajanmd @Olympics @nathanwchen @YaleCVRC In his other role, @nathanwchen stars in a music video for @eltonofficial @britneyspears & recently wrote a book 📕
@eltonofficial
Elton John
1 year
Watch the amazing music video with Olympic Gold Medalist @nathanwchen for the acoustic version of ‘Hold Me Closer’ with @britneyspears 🌹🚀 #HoldMeCloser #acoustic
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@jennkwanMDPhD
Jennifer Kwan MD PhD
3 years
⬆️ @NIH $ & bridge funding➡️crucial to enabling early career physician-scientists to stay in research careers. While medical schools have done well recruiting more trainees, CDAs have been flat over the past decade @JakeAuch @rosadelauro @RepDianaDeGette @RepFredUpton @SenMarkey
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@A_P_S_A
APSA
3 years
APSA's advocating for ⬆️$ funding support for early career #physicianscientists . This biomedical workforce = crucial for disease cures/preventions. Join us! Submit a video: show why your research/supporting early career physician-scientists is important
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Jennifer Kwan MD PhD
2 years
So grateful to catch up w/the one & only @Sugeng_Lissa , who has inspired & mentored many @YaleCardiology fellows; motivating us toward clinical & imaging excellence by example #3Decho @abouzikimd
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Jennifer Kwan MD PhD
11 months
Celebrating @YaleCardiology class of 2023 w/our graduating class. Congrats @abouzikimd on graduating #EP fellowship! @attilafehermd @ehianeni
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Jennifer Kwan MD PhD
2 months
Congrats to the #troponinteam and kudos to @ruey_hu for his vision and leadership in taking these helpful digital apps from start to finish #ACC24 @YaleCardiology @YaleMed @ACCinTouch
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@jennkwanMDPhD
Jennifer Kwan MD PhD
4 years
@NEJM @HarvardChanSPH "The intense scientific communication . . . combined with scientific advances, has enabled research to move faster than during any previous outbreak. “An unprecedented amount of knowledge has been generated in 6 weeks." #COVID2019 @ScienceMagazine
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@jennkwanMDPhD
Jennifer Kwan MD PhD
3 years
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@jennkwanMDPhD
Jennifer Kwan MD PhD
8 months
Our @JAMA_current commentary w/ @cpgYALE : We discuss ways to address $ gaps to retain phy-sci to move forward disease understanding & improve health. ie⬆️ @NIH funding to keep up w/inflation, include $ for research for health-related legislation ie PCORI etc
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@jennkwanMDPhD
Jennifer Kwan MD PhD
3 years
@repmarkpocan :If you had $10, 20, 70 billion more, what would that mean as far as research? @NIHDirector : We could provide for this amazing research workforce . . . I would focus on early stage investigators . . . they're our future . . . @PeterHotez @NIH
@NIHDirector
Dr. Monica M. Bertagnolli
3 years
Testifying before the House Appropriations LHHS Subcommittee today at 10am ET with @NICHD_NIH Diana Bianchi, @NIAIDNews Anthony Fauci, @nih_nhlbi Gary Gibbons, @theNCI Ned Sharpless, & @NIDAnews Nora Volkow. See it here: #NIH
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@jennkwanMDPhD
Jennifer Kwan MD PhD
1 year
Look forward to giving keynote talk to Chicago Tri institute MSTPs @uicmstp @UChicago @uchicagomstp @NorthwesternMed @NUMSTP tonight on my phy sci journey, current research & advocacy for #physicianscientists 👩‍🔬
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@jennkwanMDPhD
Jennifer Kwan MD PhD
6 months
Great to catch up with old & new friends at @AHAScience @American_Heart #AHA23 , look forward to continued/new collaborations! @KnowingAlok @HanZhuMD #genomics #somaticvariants #CVD
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@jennkwanMDPhD
Jennifer Kwan MD PhD
4 years
An inspirational scientist, mentor & role model using her platform to advocate for positive change & using her expertise to tackle #COVID19 @VirusesImmunity
@EricTopol
Eric Topol
4 years
So great to see my friend @VirusesImmunity and her team's pandemic leading work @YaleIBIO @YaleMed @YaleEMD @YaleSPH getting this richly deserved recognition @ScienceMagazine by @jcouzin @statnews by @scchak
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@jennkwanMDPhD
Jennifer Kwan MD PhD
4 years
Excited to have @hmkyale  as my faculty mentor for @YaleCardiology journal club tomorrow to discuss ways to assess the quality/validity of observational #bigdata studies, lessons/insights from the recent @TheLancet & @NEJM Surgisphere papers
@hmkyale
Harlan Krumholz
4 years
My comment about Surgisphere articles: '“Well-done studies are based on understanding the provenance of data & making sure what you are doing is reasonable."
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@jennkwanMDPhD
Jennifer Kwan MD PhD
2 years
Brainstorming about physician scientist career development opportunities #cardioonc #cardiorheum w/ @Bweber04 @BrighamWomens @DaniaDaye @A_P_S_A @AHAMeetings #AHA22
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@jennkwanMDPhD
Jennifer Kwan MD PhD
2 years
One of the best parts of @AHAMeetings #AHA22 is catching up with friends, colleagues over excellent science 🧪 🧬🔬🥼
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@jennkwanMDPhD
Jennifer Kwan MD PhD
2 years
Exciting work @ZhiYu_ACGT ! Exploring CHIP mechanisms for ⬆️ CAD risk w/proteomics @somalogic @OlinkProteomics in multiple cohorts, finding CHIP variant pathway signatures @AHAScience #AHA22 @pnatarajanmd @broadinstitute
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@jennkwanMDPhD
Jennifer Kwan MD PhD
2 years
@davidrliu discusses #baseediting journey➡️therapeutics, @skathire highlights 15 yrs of research ➡️translation single 💉to ⬇️CV risk, @janiceschen shows roadmap of how #geneediting tech can help w/prevention ➡️💊➡️health, Lt colonel McGovern highlights potential misuse
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@jennkwanMDPhD
Jennifer Kwan MD PhD
4 years
National study of MD-PhD & MD trainees to assess career sector/specialty/research intentions identifies important factors driving career decisions & obstacles facing this cohort; MD RI =research intense @A_P_S_A @DaniaDaye @otoubat @drbrowncares
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@jennkwanMDPhD
Jennifer Kwan MD PhD
1 year
Inspired by 🐭 model of myocarditis, we treat a severely resistant #ICImyocarditis pt w/adjunct JAKi, tofacitinib➡️sig improvement of troponins. Great job @Felipe_Matute @NNShahMD #cardioonc
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@jennkwanMDPhD
Jennifer Kwan MD PhD
1 year
Congrats to @Yale CS students for presenting your work! Developing novel algorithms to evaluate somatic #genomic 🧬variants and somatic mitochondrial variants @KnowingAlok @YaleCompsci @YaleCardiology @YaleCVRC
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@jennkwanMDPhD
Jennifer Kwan MD PhD
4 years
Co-infection rates of #COVID19 w/other resp viruses: specimens + for SARS-CoV-2, 20.7% were + for 1 or more pathogens: ie rhinovirus (6.9%), RSV (5.2%). Presence of non–SARSCoV2 virus does not mean that a pt doesn't ALSO have SARS-CoV-2 @Stanford
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@jennkwanMDPhD
Jennifer Kwan MD PhD
4 years
Cheers to @Yale & @DorisDukeFdn for supporting early career #physicianscientists who face significant caregiving demands during the #covid19 pandemic = major challenge for physci ie w/kids #rolemodel @AAMCtoday @VictorDzau @NIHDirector @the_asci @KimrynRathmell @A_P_S_A
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@jennkwanMDPhD
Jennifer Kwan MD PhD
1 year
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@jennkwanMDPhD
Jennifer Kwan MD PhD
4 months
@Yalecardiology representing @SCMR #SCMR24 w/prospective study evaluating imaging biomarkers of pts on ICI assoc w/CV outcomes.  @MohaK92  reviews CMR features assoc w/MACE, HF.  @GiniJeya  shows analyses of CMR LA strain/DGE & assoc w/outcomes in pts on ICI @CardioOnc_MR_CT @CsFuss
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@jennkwanMDPhD
Jennifer Kwan MD PhD
2 years
Evaluation of TKI, ICI adverse cardiovascular events & associated risk factors in a single center study of several 1000 cancer patients, join us today! @AkhlaghiNarges @CardioOnc_MR_CT #cardioonc #immunotherapy #ACC22 @ACCinTouch @YaleMed @YaleCardiology
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@jennkwanMDPhD
Jennifer Kwan MD PhD
4 years
Thx @YaleMed ! Insights on stress, how #physci are spending their⏲️, impact on research productivity & differences between genders, ethnicities & regions of country being revealed . . . #advocacy @drbrowncares @DorisDukeFdn @NIHDirector @VictorDzau @theNAMedicine @KimrynRathmell
@MagazineYale
Yale Medicine Magazine
4 years
Recently, @Yale physician-scientist @jennkwanMDPhD conducted a survey on how COVID-19 has impacted colleagues. @YaleMed
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@jennkwanMDPhD
Jennifer Kwan MD PhD
11 months
Retrospective study of #breastcancer pts: we evaluated effects of anthracycline/Her2i (AT) vs those w/o on #CMR imaging characteristics & outcomes. AT w/⬆️biV volumes,⬇️RVEF. Most w/abnormal strain; anthracycline grp:⬆️abnormal GLS compared to those w/o
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@jennkwanMDPhD
Jennifer Kwan MD PhD
8 months
Great to be part of the @FondationLeducq @WUSTLmed #immunocardiology conference @jacksonlab , lots of cutting edge research on the interface of immunology & cardiac homeostasis/disease #fibroblast #immunecell #cardiaccrosstalk in #CVD #somaticvariants #CHIP #ICI #CART #FAP
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@jennkwanMDPhD
Jennifer Kwan MD PhD
3 years
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@jennkwanMDPhD
Jennifer Kwan MD PhD
2 years
How can #multimodality molecular imaging/ #AI / #bigdata help in elucidating mechanisms of oncologic therapy/immunotherapy related CV toxicities as well as help w/detection, diagnosis, prognostication? Our review in @FrontCVMedicine w/ @ekoikonomou , Albert Sinusas #cardioonc
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@jennkwanMDPhD
Jennifer Kwan MD PhD
3 years
~2 million cancers diagnosed in US in 2020. ~36% of cancer patients = eligible for ICI. Increasing indications for ICI therapies: will be important to monitor for adverse CV outcomes ie #myocarditis   @ACCinTouch #Cardioonc @TomasNeilan @JAMA_current
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@jennkwanMDPhD
Jennifer Kwan MD PhD
4 years
Yes, we're seeing this disparity for early career👩‍🔬 physician scientists, particularly if they have children🤱from our @A_P_S_A #COVID19 survey. Goal: assess impact of #COVID19 on MD/PhD trainees to residents/fellows/junior faculty in terms of training/career/wellness #advocacy
@EricTopol
Eric Topol
4 years
#COVID19 and the gender inequity in academics @PNASNews @MalischPhd and colleagues @AAUW and a broader analysis @ScienceMagazine @JoeCimpian #WomeninScience Both are compelling
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@jennkwanMDPhD
Jennifer Kwan MD PhD
2 years
Join us for this session today w/ @AkhlaghiNarges co-presenting this work! Implications for #ici myocarditis management @Milesshen8 @YaleCardiology @CardioOnc_MR_CT
@jennkwanMDPhD
Jennifer Kwan MD PhD
2 years
Excited our  @American_Heart abstract was accepted for oral presentation #AHAscientificsessions . + #AT1R autoantibodies➡️need for⬆️immunosuppression in immune checkpoint inhibitor myocarditis pts #immunotherapy #cardioonc   @CardioOnc_MR_CT
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