David Sinclair @davidasinclair Twitter profile

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@AstroJaws

David Sinclair

@davidasinclair

4 years

For those who wanted a world without vaccines, witness the world without one vaccine.

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David Sinclair

@davidasinclair

3 months

Dude, in that photo I was 35 🤦‍♂️

Brainflow 🧬

@Brainflow_

3 months

The exact longevity supplements that Harvard scientist Dr. David Sinclair uses. He's 54 but literally looks 35. -An overview of 13 supplements/drugs -Their underlying logic -Recommended dosages (Save this thread for reference) THREAD🧵

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David Sinclair

@davidasinclair

4 years

Since my Harvard lab closed yesterday, I've been reading and interpreting this week's published papers on #COVID19 . What follows is a thread of information, my interpretation, links to sources & predictions. Let's start with what you need to know... #coronavirus #COVID ー19

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David Sinclair

@davidasinclair

10 months

This new discovery offers the potential to reverse aging with a single pill, with applications ranging from improving eyesight to effectively treating age-related diseases 14/17

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David Sinclair

@davidasinclair

1 year

Disagree @elonmusk . Studies of identical twins show longevity is 80-90% epigenetic, meaning it can be changed by lifestyle, for the same reason a queen bee raised on royal jelly can live 10 times longer than a genetically identical worker 🐝

Elon Musk

@elonmusk

1 year

@paulg Our lifespan is programmed into our genes, just like it is for fruit flies or pets. Fruit are already vegan & even if they do yoga every day & take every supplement, they still only live 50 days.

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David Sinclair

@davidasinclair

2 years

The longer your food lasts, the shorter you will

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David Sinclair

@davidasinclair

1 year

Delighted to share with you our latest paper. Here, we test the hypothesis that aging may be driven by DNA damage-induced changes to the epigenome. Mightbe due to a glitch in the software of the body that causes it to malfunction, which can be fixed with a reboot?👇 1/

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David Sinclair

@davidasinclair

1 year

New paper provides evidence that black holes are the origin of dark energy & the expansion of the universe. Yeah, that’s a big deal

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David Sinclair

@davidasinclair

10 months

Grateful to share our latest publication: We’ve previously shown age reversal is possible using gene therapy to turn on embryonic genes. Now we show it’s possible with chemical cocktails, a step towards affordable whole-body rejuvenation 1/17

Chemically induced reprogramming to reverse cellular aging | Aging

Aging | doi:10.18632/aging.204896. Jae-Hyun Yang, Christopher A. Petty, Thomas Dixon-McDougall, Maria Vina Lopez, Alexander Tyshkovskiy, Sun Maybury-Lewis, Xiao Tian, Nabilah Ibrahim, Zhili Chen,...

www.aging-us.com

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David Sinclair

@davidasinclair

1 year

Factors that accelerate epigenetic aging: 1. Smoking (worst) 2. Alcohol intake 3. Waist size 4. Body fat 5. CRP (inflammation) 6. Triglycerides 7. Childhood obesity 8. Type 2 diabetes (Alcohol is turning out to be more toxic than we thought. Sorry)

Genetic Evidence for Causal Effects of Socioeconomic, Lifestyle, and Cardiometabolic Factors on...

Abstract. GrimAge acceleration (GrimAgeAccel) and PhenoAge acceleration (PhenoAgeAccel) are DNA methylation-based markers of accelerated biological aging,

academic.oup.com

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David Sinclair

@davidasinclair

2 years

Study of 135K people finds high carb diets have highest mortality & high fat the lowest. Total fat intake was not associated with heart disease 😳 Authors: “Global dietary guidelines should be reconsidered.”

Associations of fats and carbohydrate intake with cardiovascular disease and mortality in 18...

High carbohydrate intake was associated with higher risk of total mortality, whereas total fat and individual types of fat were related to lower total mortality. Total fat and types of fat were not...

www.thelancet.com

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David Sinclair

@davidasinclair

4 years

What science says about maximizing life: 1. Eat less often. 2. Avoid sugar & high GI foods. Eat stressed plants. 3. Do hip-hinge exercises, stretch, pant a few times a week. 4. Block blue light. Sleep well. 5. Calm your mind, never lie, don't hate. 6. Have close friends & pets.✌️

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David Sinclair

@davidasinclair

3 years

Why would I want 50 more years of life? Because I’m finally getting the hang of it

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David Sinclair

@davidasinclair

1 year

Age reversal works in primates to restore vision. Announced by my collaborator Dr. Bruce Ksander & @lifebiosciences . Next up: age reversal in humans. How’s that @elonmusk ? 🚀 1/10…

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David Sinclair

@davidasinclair

4 years

Now we understand a tiny bit what it’s like living in a pre-vaccine world. Salk’s inactivated polio vaccine launched on a Friday (Mar. 12, 1954) changes the world by reducing cases of childhood paralysis from 350,000/year in 1988 to 33 in 2018... #FridayMotivation #FunFactFriday

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David Sinclair

@davidasinclair

2 years

Aging is a disease and that disease is treatable

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David Sinclair

@davidasinclair

3 years

In the future, rather than an annual checkup, our health will be monitored a million times a second and the alternative will seem medieval

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David Sinclair

@davidasinclair

2 years

Aging and cancer have the same root cause: cells forget how to behave. Aging is reversible. Maybe cancer is too

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David Sinclair

@davidasinclair

2 years

Accidentally hit and crushed 2 doors of a parked car. Left my phone #. Owner's response made my day

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David Sinclair

@davidasinclair

1 year

Working on it

Lex Fridman

@lexfridman

1 year

I hate that every awesome thing comes to an end. I wish it would last forever.

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David Sinclair

@davidasinclair

11 months

Scientists conclude that Alzheimer's a "natural part of human brain aging." Sorry folks. Stop the research. Alzheimer's is no longer a disease

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David Sinclair

@davidasinclair

10 months

New approach to age reversal @elonmusk : Life is information. When corrupted, we age & die. Found a backup copy (cf Shannon). With genes & chemicals, we reboot the body. Works in monkeys to restore vision. Humans next

Elon Musk

@elonmusk

10 months

@davidasinclair Ok, so what exactly is it?

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David Sinclair

@davidasinclair

1 year

Took me 50 years and a lot of getting screwed to come to terms with the fact that there isn’t good in everyone

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David Sinclair

@davidasinclair

2 years

We’re trained to think that the cellular changes caused by aging are irreversible. I’ve seen no evidence for that

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David Sinclair

@davidasinclair

3 years

I have come to realize the key to success in life is not brains or luck, it's tenacity

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David Sinclair

@davidasinclair

1 year

Announcing to the team we received acceptance at a top scientific journal of a 13 year study to test The Information Theory of Aging… 1/n #harvard

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David Sinclair

@davidasinclair

3 years

If you’re not shocked by the thought of who you were 10 years ago, you’re not growing

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David Sinclair

@davidasinclair

2 years

Your aging clock ticks over every day. Science says the earlier you change your lifestyle to slow aging, the healthier and more vibrant you will be and will remain. Why wait?

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David Sinclair

@davidasinclair

3 months

New study finds immune T cells engineered to kill zombie senescent cells 🧟‍♀️ can reverse key aspects of aging in mice 🐁 including metabolic & physical decline. Imagine a single treatment that protects from aging, for life…see thread

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David Sinclair

@davidasinclair

3 years

Never hire people based on skills. Look for passion & raw talent. These cannot be taught.

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David Sinclair

@davidasinclair

10 months

If aliens saw us speaking to people overseas on pocket devices, speeding in self-driving cars, and flying in giant planes, they’d be shocked that aging still hadn’t been solved

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David Sinclair

@davidasinclair

4 years

Treatments that seem to work are chloroquine (a cheap malarial drug), Gilliad's remdesivir with interferon-beta (in clinical trials from COV-19), plasma from recovered patients, and a steroid (methylprednisilone). Doctors in US are now using remdesivir off-label...

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David Sinclair

@davidasinclair

4 years

Finally had time to carefully read the new preprint that claims to reverse the age of rats by 54%. I spoke to the first author & in this thread ask whether the results are believable and what if it is true? 1/n

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David Sinclair

@davidasinclair

2 years

Matcha, or Japanese ceremonial green tea, is one of the world’s healthiest drinks. Not because of antioxidants but survival molecules that Camillia sinensis makes when grown in the shade. When we ingest them, they boost our survival enzymes to fight aging & disease 💪 1/7

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David Sinclair

@davidasinclair

11 months

A nightmare substance would be one that, in low doses, protects the heart, but is toxic to the brain. According to research in the last few years, that substance is alcohol… 🍷

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David Sinclair

@davidasinclair

3 years

Paradigm shifts: 1910s - Flight 1930s - Antibiotics 1950s - Space 1970s - PCs 1980s - Internet 1990s - Genomics 2000s - Smartphones 2010s - Energy 2020s - Age reversal

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David Sinclair

@davidasinclair

2 years

If aging were optional, would you choose to stay young?

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David Sinclair

@davidasinclair

2 years

Dr. Eric Kandel, the energetic neuroscientist and Nobel winner, is retiring at 92. It remains unclear why he chose early retirement

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David Sinclair

@davidasinclair

1 year

Each day, if you can, set aside 10 minutes for quiet time, breathing deeply, appreciating all you have. If you’re just too busy, do it for 30 minutes

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David Sinclair

@davidasinclair

2 years

Life never gets easier, no matter how long you live. All you can do is get better at it

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David Sinclair

@davidasinclair

1 year

@elonmusk @lexfridman It is a human right to choose when you die. This will become a reality

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David Sinclair

@davidasinclair

1 year

Human trials with longevity molecules that directly activate Sirtuins will begin again in 6 months, 13 years after bad science from Pfizer almost killed my lab and the entire field. Onward! 🙏🚀

Does SIRT6 hold the key to human longevity?

Longevity focused biotech SIRTLab emerges from stealth, aiming for first human trials of SIRT6-boosting therapeutic within six months.

longevity.technology

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David Sinclair

@davidasinclair

2 years

Imagine a future when aging is optional

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David Sinclair

@davidasinclair

3 years

Wow! First time all my local @Tesla chargers are occupied (and I’m 3rd in line!). Happy for @elonmusk & our planet! ⚡️🌎🌳

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David Sinclair

@davidasinclair

2 years

A long, healthy life isnt a given. You earn it

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David Sinclair

@davidasinclair

1 year

The 13 year study often took me away from you. Now it’s finally done. Thank you for you patience. I love you ❤️

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David Sinclair

@davidasinclair

3 years

It is incontrovertible that skipping meals while maintaining adequate nutrition is not only good for you but will make you live longer

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David Sinclair

@davidasinclair

1 year

1. Everyone has a right to lifespan extending medicines 2. Lifespan extension must be optional 3. Lifespan extension must be a consequence of improved health 4. No one should be subjected to biological age discrimination 5. Lifespan extension must be available to other species

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David Sinclair

@davidasinclair

1 year

Should we reverse aging? Age reversal is coming @elonmusk . That’s like asking: Should we develop AI? Build reusable rockets? Go electric? Purely academic questions, amusing to those who are making it happen 🚀 @waitbutwhy @lexfridman

Elon Musk

@elonmusk

1 year

@waitbutwhy The precision of our biological clock across trillions of cells is incredible. One never sees someone with an old left arm, but a young right arm. Aging can obviously be fixed. The real question is whether it should be.

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David Sinclair

@davidasinclair

3 years

Age reversal isn’t a miracle. It’s a lifestyle

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David Sinclair

@davidasinclair

2 years

The new science of aging says the process starts ticking even before you’re 20. So don’t wait to live a lifestyle that slows aging. Act now.

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David Sinclair

@davidasinclair

4 years

Blood, HbA1c, and chloroquine CoV2 mutations Symptoms Susceptibility/Risk Fatality Therapies Remdesivir ☮️

NIH clinical trial of remdesivir to treat COVID-19 begins

Study enrolling hospitalized adults with COVID-19 in Nebraska.

www.nih.gov

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David Sinclair

@davidasinclair

2 years

One meal a day (OMAD) is increasingly popular. Even when eating the same number of total calories, those on OMAD burned more fat, had lower blood glucose, and experienced no reduction in lean muscle mass, aerobic fitness or strength 💪

Frontiers | Differential Effects of One Meal per Day in the Evening on Metabolic Health and...

Background: Generally, food intake occurs in a three-meal per 24 h fashion with in-between meal snacking. As such, most humans spend more than ∼ 12–16 h per ...

www.frontiersin.org

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David Sinclair

@davidasinclair

5 months

Our next installment of epigenetic rejuvenation via age reversal is out: 2 months of OSK gene therapy in mice with glaucoma fully restores their vision, with no evidence of side-effects, even after prolonged use. Congrats to Bruce Ksander, @YuanchengLu , and the entire team 👏🏻🙏…

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David Sinclair

@davidasinclair

3 years

Production is in full swing, separating fact from fiction on my limited scientific podcast series on health & longevity: 1. Skipping meals/fasting 2. Infrared saunas/cryotherapy 3. Hyperbaric oxygen chambers 4. Peptides 5. Senolytics 6. Metformin/rapamyin 7. NAD, NR, NMN

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David Sinclair

@davidasinclair

2 years

We all have an internal life clock. Each day, we make decisions that cause the clock to tick over much faster or slower, depending on when & how much we eat, sleep & exercise. It’s hard to be perfect but it helps to ask: “What would my future self want me to do today?”

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David Sinclair

@davidasinclair

4 years

A loss of smell is emerging as a symptom of #COVID -19. Might be due to the silencing of a gene called sonic hedgehog and a loss of signaling factors that cause stem cells to divide in the tongue and nose. Alpha-lipoic acid seems to help. Here's the paper:👃

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David Sinclair

@davidasinclair

3 years

People who work longer, live longer. Find what you love. Do that. Live longer! Win win!!

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David Sinclair

@davidasinclair

2 years

There’s nothing better than realizing how easy it is to slow the pace of aging

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David Sinclair

@davidasinclair

11 months

New study: Gut bacteria convert choline from RED MEAT into TMA, which becomes TMAO, a chemical that may cause cardiovascular disease. Berberine, a natural molecule that lowers blood sugar (like metformin does) also inhibits production of TMAO 💪

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David Sinclair

@davidasinclair

3 years

Pfizer vaccine, 2nd dose. No symptoms at all. Hooray for science!!! #vaccinated

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David Sinclair

@davidasinclair

7 months

Article on how DNA repair alters the epigenome to erase youthful information and drive aging, and how to reset the system #informationtheoryofaging

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David Sinclair

@davidasinclair

10 months

Some containers release as many as 4.22 million microplastic and 2.11 billion nanoplastic particles within 3 min of microwave heating. Refrigeration for over six months can also release billions of microplastics and nanoplastics 😮

Agingdoc⭐David Barzilai🔔MD PhD MS MBA DipABLM🩺

@agingdoc1

10 months

Assessing the Release of Microplastics and Nanoplastics from Plastic Containers and Reusable Food Pouches: Implications for Human Health @ACSPublications

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David Sinclair

@davidasinclair

4 years

...But there was also a naysayer in the same issue of the @nytimes . Albert Sabin, Salk’s competitor, said the research was going too fast, proving that even the greatest breakthroughs have their critics. #FridayMotivation #science #FunFactFriday

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David Sinclair

@davidasinclair

5 years

As I approach 50, I appreciate the people who have reached out to tell me that I look younger than my age. What's my secret? Diet? Exercise? Longevity molecules? Nope: Old photos.

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David Sinclair

@davidasinclair

2 years

Most cancers require high glucose to proliferate and survive. In 🐭, a low sugar, high protein diet reduced tumor size & death rates, indicating that lowering blood sugar levels & increasing protein may be a way to prevent & treat cancer

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David Sinclair

@davidasinclair

2 years

It’s finally out! @hubermanlab

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David Sinclair

@davidasinclair

3 years

If you think life’s too short, do something about it

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David Sinclair

@davidasinclair

11 months

When you eat sugar, some of it attaches to your body’s proteins, an aging process called glycation. New study says oral resveratrol protects against glycation & kidney damage in a sugar-induced aging mouse model. Me: still taking resveratrol in yogurt

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David Sinclair

@davidasinclair

10 months

@elonmusk @PeterDiamandis Hey @elonmusk , @PeterDiamandis , my lab will be publishing new age reversal results later today. Stay tuned 🚀

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David Sinclair

@davidasinclair

3 years

So excited about my 8-part podcast series. Will dedicate an entire show separating fact from fiction about the use of NR, NMN & NAD IVs to slow aging 💊💉📢 #podcastlife #aging #longevity Useful paper:

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David Sinclair

@davidasinclair

1 year

Healthy people who reduced their caloric intake 25% became epigenetically younger, based on the DunedinPACE of aging clock, and the effects were seen in a year

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David Sinclair

@davidasinclair

1 year

Amazing! New paper shows biological age rapidly increases during stress & reverses when the stress is relieved. That’s a relief 😅

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David Sinclair

@davidasinclair

3 years

Stay calm. Always. Getting rescued from a stuck elevator in a 50 story NYC hotel at 5am & missing my ✈️ should have raised my heart rate. No way! It’s still going to be a great day!

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David Sinclair

@davidasinclair

2 years

If you’re offended by the idea that you have a slow, progressive disease, you’re in denial. If you think you can’t do anything about it, you’re even more in denial #agingisadisease

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David Sinclair

@davidasinclair

4 years

...the virus could more easily disrupt the heme in red blood cells. If so, the virus is very smart: it destroys the lung so patients can't take up oxygen AND reduces the body's ability to carry oxygen. (For this & other reasons, you should eat healthily the next 2 years)...

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David Sinclair

@davidasinclair

1 year

Living in low 11% oxygen (rather than air at 21%) extends a mouse’s lifespan by 50% and delays the onset of neurological debility in an accelerated aging model. Hormesis?

Hypoxia extends lifespan and neurological function in a mouse model of aging

Aging is one of the strong risk factors for the most common diseases on our planet, but we have few interventions that delay aging (including dietary restriction). This study reveals that a different...

journals.plos.org

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David Sinclair

@davidasinclair

2 years

Me, to my 82 year-old dad: “You still don’t have any diseases!” Dad: “Yes I do. I’ve got aging.”

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David Sinclair

@davidasinclair

10 months

Age reversal is real. Trick is landing on A1, not A0

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David Sinclair

@davidasinclair

5 years

We become scientists because we're curious, because we're problem-solvers, and because we're addicted to awe. But, like many things people start doing for love, money eventually comes into play. Here's one path for aligning love with reality.

Toward a science of service

No one becomes a scientist to get rich. Children don't gaze at the stars and think "how can I capitalize on the cosmos?" Teens, exploring genetics for the first time, don't extract the DNA from a...

www.linkedin.com

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David Sinclair

@davidasinclair

2 years

Okay, this is a big deal: Vaccinations against aging work. Sure, it’s a proof-of-principle study in a rapidly aging mouse, but there’s little doubt this will be possible in us one day. Link👇1/3

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David Sinclair

@davidasinclair

2 years

The type 2 diabetes drug metformin is finally shown to slow aging! Aging needs to be called a “disease”⁩ so drugs like metformin can be prescribed before we get sick ⁦ @US_FDA ⁩

Frontiers | Effect of metformin on the epigenetic age of peripheral blood in patients with diabetes...

Background: Metformin has been proven to have an antiaging effect. However, studies on how metformin affects global epigenetic regulation and its effect on t...

www.frontiersin.org

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David Sinclair

@davidasinclair

2 years

You know you’re getting old when a friend’s daughter writes an elementary school project about you that begins, “He was born on June 26th, 1969. He is still alive.”

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David Sinclair

@davidasinclair

2 years

Having a positive attitude seems to boost immunity & even slow aging. But how? New study 🐭 shows neurons in the insular cortex increase the number & activity of immune cells in the gut & around organs. Breakthrough!👇1/6

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David Sinclair

@davidasinclair

2 years

Human umbilical cord plasma injected weekly into elderly subjects for 10 weeks reduced epigenetic age by an ave of 0.82 years & improved kidney function 😎 In the future, we will celebrate negative birthdays

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David Sinclair

@davidasinclair

4 years

In your 20s, you dream of a perfect life. In your 30s & 40s, you work hard to achieve a perfect life. In your 50s, it dawns on you: there is no perfect life.

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David Sinclair

@davidasinclair

4 years

..new work out of China yesterday says COVID-19 might also involve abnormal blood production. CoV genes 1 & 8 are predicted to interfere with heme, the red compound in blood, by kicking out the iron. Would explain why chloroquine seems effective as a treatment #CoronaVirusUpdate

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David Sinclair

@davidasinclair

2 years

Ovarian aging predicts aging rates in other tissues. Women reaching menopause before 40 are 2x as likely to die early than those reaching it between 50-54. Reversing ovarian aging may help reverse overall aging. In mice we’ve done it. Let’s give women the option ⬇️

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David Sinclair

@davidasinclair

2 years

Aging is a treatable disease

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David Sinclair

@davidasinclair

2 years

You have two ages. One is the number of times Earth has circled the Sun and the other is your biological age. Guess which one you can change easily

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David Sinclair

@davidasinclair

3 years

In the first half of life, find a great mentor. In the second half, be one

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David Sinclair

@davidasinclair

2 years

A 1000 year lifespan is short. The first 50 years of my life went by in a blink. 1000 years is only 20 blinks

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David Sinclair

@davidasinclair

1 year

Chronic alcohol consumption increasingly seen as damaging to the brain. This paper says liquor accelerates epigenetic age in youths

Alcohol consumption and epigenetic age acceleration in young adults | Aging

Aging | doi:10.18632/aging.204467. Drew R. Nannini, Brian T. Joyce, Yinan Zheng, Tao Gao, Jun Wang, Lei Liu, David R. Jacobs, Pamela J. Schreiner, Chunyu Liu, Qi Dai, Steve Horvath, Ake T. Lu,...

www.aging-us.com

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David Sinclair

@davidasinclair

3 years

Rhonda Patrick @foundmyfitness has co-written a paper on the science behind the health benefits of saunas 👏 #HealthyLiving

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David Sinclair

@davidasinclair

3 years

Things that accelerate aging: * A sedentary lifestyle * Alcohol abuse * Obesity * Inadequate nutrition * Persistent psychological stress Thanks, 2020. Ref:

Early detection of accelerated aging and cellular decline (AACD): A consensus statement - PubMed

The cellular hallmarks of accelerated aging and their clinical expression may be grouped using the terms 'accelerated aging and cellular decline' (AACD) and/or 'age-associated cellular decline'. This...

pubmed.ncbi.nlm.nih.gov

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David Sinclair

@davidasinclair

1 year

The wife of my friend just passed. She was 78. He’s 93, still active, researching longevity and, despite deep grief, “excited by the future.” He is also my hero

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David Sinclair

@davidasinclair

3 years

Head towards the thing you are avoiding. It is never that bad

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David Sinclair

@davidasinclair

2 years

Never let anyone get away with saying your physical decline is “normal for your age.” They wouldn’t say that about cancer. What’s the difference?

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