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Karl Deisseroth Profile
Karl Deisseroth

@KarlDeisseroth

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Neuroscience/medicine/writing
https://t.co/zkibqUQA7M
Joined August 2015
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
2 months
congratulations @LinlinZFan & team... tracking natural *inhibitory* synaptic plasticity in mammals! w/ the very same designed-opsin pair that we had generated earlier to track *excitatory* plasticity in behaving mice (our structure-guided channelrhodopsin bC1C2TG & QuasAr6a)…
@LinlinZFan
Linlin Fan
@LinlinZFan
2 months
Excited to share our new work @ScienceMagazine -we demonstrated all-optical interrogation of inhibitory synaptic transmission and plasticity during behavior! Kudos to our wonderful collaborators @BarnaDudok , @SolteszLab , and of course, my amazing mentor and advisor @KarlDeisseroth
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
3 years
Some rare personal news… My first calling, as many of you know, was writing. I’ve always found (unreasonable levels of) joy in working with words. Now I’ve somehow written a book: Projections. @randomhouse 1/12
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
2 years
An incredibly thoughtful conversation from @lexfridman ! spanning so much, beginning with the book (Projections) & bridging neuroscience, psychiatry, literature, cinema, the Brothers Karamazov, Finnegans Wake... human emotion & connection. Thanks Lex, talk again anytime my friend.
@lexfridman
Lex Fridman
@lexfridman
2 years
Here's my conversation with @KarlDeisseroth , psychiatrist and neuroscientist at Stanford. We talk about the human mind and the human condition. Thanks to @hubermanlab for introducing us. Also, I mistyped the original tweet. Need that edit button ASAP.
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
3 years
Grateful to everyone for reaching out today! Here’s a tribute to Peter and Dieter, my good friends in this globe-spanning collaboration. Open-access, so pass it on if you like… International unity in the service of science is more important now than ever.
@LaskerFDN
Lasker Foundation
@LaskerFDN
3 years
Join us NOW to see the winners of the Basic Award!—Dieter Oesterhelt of @MPI_Biochem , Peter Hegemann of @HumboldtUni , and @KarlDeisseroth of @StanfordMed —for “light-sensitive microbial proteins and #optogenetics ” #Lasker2021 #LaskerLaureate #LaskerAward
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
1 year
As a resident I was intrigued by stats linking panic with cardiac disorders (mitral prolapse/tachycardia). 20 yrs later we finally could explore this! (w/ @HsuehBrian @ritchie_chen ). William James on the right track: “we feel...afraid because we tremble”.
@ritchie_chen
Ritchie Chen
@ritchie_chen
1 year
We’re excited to extend noninvasive optogenetics beyond the brain to address a nearly 150-year-old question in a new study out today @Nature : Work led by @HsuehBrian , myself, and @KarlDeisseroth , with an amazing team in the D-lab and many others!
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
4 years
Glad we got the minivan... didn’t predict it would be useful this way!
@michelle_monje
Michelle Monje🎗️
@michelle_monje
4 years
Bringing Qiagen RNA extraction kits from the research labs to the clinical lab for COVID19 testing. #teamwork
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
3 years
Projections launches today! 20 yrs in the making. Hard to describe the feeling—like introducing your closest lifelong friends, who had never met each other, for the first time. Thanks to all @RandomHouse & heartfelt welcome to all. Share as you like!…
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Projections by Karl Deisseroth: 9781984853714 | PenguinRandomHouse.com: Books

A groundbreaking tour of the human mind that illuminates the biological nature of our inner worlds and emotions, through gripping, moving—and, at times, harrowing—clinical...

www.penguinrandomhouse.com
@randomhouse
Random House Group
@randomhouse
3 years
The summer stacks just keep on coming! Which new releases are you adding to your TBR list?
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
3 years
There’s nothing harder in clinical medicine than childhood brain cancer– in every way. And yet @michelle_monje , the strongest person I know, has made it her calling, and is truly making a difference. Against all odds– advancing the science, treating & helping children, together.
@macfound
MacArthur Foundation
@macfound
3 years
Let's take a moment today to celebrate boundless creativity...🧠⚡ Meet the 2021 MacArthur Fellows, 25 extraordinarily creative and inspiring individuals in all fields of endeavor: 🎼🌎🩺😷⚖️🖼️🇰🇵🇰🇷🔬🎨🎥🖤🇵🇷🌍🇺🇸🇲🇽🗳️👩‍🦯♿🧠📱🪨➡️🌱📈📽️✊🦠💃
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
6 months
Thank you... Very proud of this excellent team and their creative work over many years! A multifaceted study exploring the global and causal brainwide dynamics of resolving needs into goals, led by Ethan Richman with Nicole Ticea, @weallen1 and Liqun Luo:
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@ikauvar
Isaac Kauvar
@ikauvar
6 months
Very excited about Ethan Richman’s study that provides deep insight into competition between homeostatic needs! The work has it all — a new behavioral assay, brain-wide Neuropixels + optogenetics, and a new framework for understanding brain state dynamics.
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
8 months
Congratulations to this constantly amazing group of students, postdocs, staff & collaborators including the indomitable @yoon_Seok_Kim , with @emekato , @sokosoko_seeya & our whole structure team! A new mechanism for K+ selectivity->new tools for biology. …
@Yoon_Seok_Kim
Yoon Seok Kim
@Yoon_Seok_Kim
8 months
1. Excited to share our work-the formal version of last year's first preprint of K+ selective ChR (KCR) structures 'Structural Basis for Ion Selectivity in Potassium-Selective Channelrhodopsins' published in @CellCellPress ! (1/9)
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
6 months
Hard to believe it’s been exactly 20 years since that 2003 faculty search launching Stanford Bioengineering, that landed “a physicist, a chemist, and a psychiatrist” (great quote from Steve Quake @ 1min50s). As the 3rd of those 3 wildcards (with Steve and Jennifer Cochran), I’m…
@StanfordEng
Stanford Engineering
@StanfordEng
6 months
Bioengineering is where life sciences and engineering meet. In this video, bioengineers at Stanford take us through the last two decades of their research and teaching, and share their well-earned optimism for the future of the field. @StanfordMed
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
1 year
NB: the brilliant @LinlinZFan used new optogenetic tools here for 4 *separate* purposes! to elicit plasticity in single cells, measure excitability of cells, ping projections, & test presynaptic activity-dependence of plasticity– optically & alongside voltage imaging & behavior…
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@LinlinZFan
Linlin Fan
@LinlinZFan
1 year
1. I’m excited to share our new work, conducted with my amazing mentor and advisor @KarlDeisseroth , on the synaptic basis of behavioral timescale plasticity. Online today @CellPressNews :
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
3 years
A complex, rewarding week just wrapped up: intense psychiatry inpatient-attending duty over the nights, interleaved with mornings of energetic, if somewhat disheveled, recording of the Projections audiobook…
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
5 years
Congratulations to an amazing group of scientists, bringing together multiple new discoveries to achieve a long-sought goal: creating specific perceptions in the mammalian brain at the level of individually-defined cells (& criticality of the dynamics explored with @SuryaGanguli )
@Yoon_Seok_Kim
Yoon Seok Kim
@Yoon_Seok_Kim
5 years
New work @Science ! Powerful, red-shifted opsin ChRmine, combined with MacroSLM , provides 3D read-write brain access! Kudos to a super team, with @JimMarshel , @machado_ta , Sean and others, with the mastermind @KarlDeisseroth !
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
4 years
Best ceremony “crashers” ever! Grateful for this family😀-- & to the Royal Netherlands Academy-- & to all the trainees/collaborators who developed optogenetics with me over many years. Likewise to the hydrogel-tissue chemistry team- the honor of a lifetime to work with you all…
@michelle_monje
Michelle Monje🎗️
@michelle_monje
4 years
A silver lining of the pandemic is getting to attend @KarlDeisseroth ‘s prize ceremony as a family in the middle of the #WFH #distancelearning day 😊🍾
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
4 years
Thank you to the Royal Netherlands Academy of Arts and Sciences & all the students/postdocs in my lab whose development of optogenetics took many years from humble origins . They came from around the world, as did our collaborators .
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
4 years
😀long ago, Viviana was a key member of the tiny group of grad students designing/creating the critical components of optogenetics in my lab in the early years. Now she joins them—as another winner of the SfN YIA prize—for beautiful work in her own lab. Congrats Dr. Gradinaru!
@SfNtweets
Society for Neuroscience (SfN)
@SfNtweets
4 years
Congratulations to @VivianGradinaru from @Caltech and Weizhe Hong ( @thehonglab ) from @UCLA for winning the Young Investigator Award! The Young Investigator Award is supported by @Sunovion . #SfNAwards20 #TakeOnTomorrow
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
6 years
How do channelrhodopsins work as molecules? High-resolution mechanisms of selectivity, speed & color , . Thanks to a super team- 6 wonderful intense yrs after our initial 2012 structure of the light-gated pore. Proteins are beautiful.
@Yoon_Seok_Kim
Yoon Seok Kim
@Yoon_Seok_Kim
6 years
Our papers about insights into selectivity, gating, spectra, and many interesting aspects about channelrhodopsins are out @nature , as two Articles! Enormous kudos to my incredible teammates, namely @emeKato and @KarlDeisseroth !
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
3 years
Trying to do better public outreach for science... we need to. Thanks to the Sloan Foundation Program in Public Understanding of Science, I chatted w/ Alan Alda– every bit as much fun as you might think!– from science to sprung rhythm; then he sprang 7 surprise questions ~31:00.
@alda
Clear+Vivid
@alda
3 years
That's right, it's #ClearAndVivid PODCAST DAY! @alanalda chats with author & neuroscientist, @KarlDeisseroth . With the invention of new ways to explore the brain, he has revolutionized neuroscience. Listen now on your favorite podcast destinations:
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
5 years
Creative work from a great team, meeting an enormous challenge... Vertebrate brain states and transitions specifically observed, controlled, and modeled, via real-time cellular-resolution activity access across the entire brain during adaptive behavior! @AaronAndalman @rajankdr
@CellCellPress
Cell
@CellCellPress
5 years
Online Now at Cell from @KarlDeisseroth and colleagues: Brainwide imaging in zebrafish and network modeling reveal switching from active to passive coping state arises from progressive activation of #habenular #neurons in response to behavioral challenge
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
2 years
Recalling the profound impact ~25 yrs ago of seeing the 1st K channel structure of MacKinnon & team. For years, that elegant selectivity motif seemed universal. It’s cool, in channelrhodopsins no less! to find the structure for a distinct mechanism. Kudos to our chemistry team...
@Yoon_Seok_Kim
Yoon Seok Kim
@Yoon_Seok_Kim
2 years
1.We are thrilled to share our newest preprint, reporting structural insight into the K+ selectivity in channelrhodopsins (ChRs), with @KarlDeisseroth @emeKato . Resolving this mystery has been a holy grail of optogenetics and opsin physiology!
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
1 year
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
4 years
GTCA (genetically targeted chemical assembly) paper: and thanks to Christine Schmidt and Kevin Otto for the nice perspective
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
4 years
Congratulations to a great team! and a wonderful seven-year collaboration between our group and @zhenanbao 's lab in Chemical Engineering. Initial step into a new domain spanning chemistry and genetics within living systems. So many ideas now emerging...
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
4 years
Congrats @SamVesuna @ikauvar & team! An idea nurtured in a clinical subgroup that we grew to link eclectic perspectives. Optogenetics, widefield imaging, patient care, & brainwide electrophysiology in mouse & human, came together to address a deep mystery.
@ikauvar
Isaac Kauvar
@ikauvar
4 years
Will some principles in neuroscience require a brainwide, fast, cellular-level perspective for discovery? We’re delighted to share our new paper reporting an outcome of this approach: @Nature , co-led by @SamVesuna and me, and mentor @KarlDeisseroth . (1/n)
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
6 years
Congratulations to all new #NASmembers including the remarkable @zhangf (well done Feng! first lab alum elected to the National Academy of Sciences, and I feel as though I have a lab full of future NAS members). I'm fortunate to work with these amazing scientists every day.
@HHMINEWS
HHMI NEWS
@HHMINEWS
6 years
Congratulations to all the newly elected #NASmembers , including the following HHMI Investigators and Professors: Yang Dan, Daniel Haber, Akiko Iwasaki, Karolin Luger, Alejandro Sanchez-Alvarado, Christopher Walsh, Utpal Banerjee, Sarah Elgin, and Feng Zhang.
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
5 years
Cheers to a great team! & long-sought milestone- 2008: initial redshifted channelrhodopsin, from Volvox. 2012: initial single-cell control in mice, w/ Volvox-derived ChR. Now behavior elicited by specified sets of single cells in mice w/ Volvox-derived ChR
@joshjennings0
Josh Jennings
@joshjennings0
5 years
What an honor and pleasure to work with such a great group of people on this project. A huge thanks to Tina for being an awesome teammate+friend, Karl for having the best lab+vision, and Jim+rest of the team @KarlDeisseroth @omgtinakim
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
6 years
Nice article out of Princeton on the brilliant @IlanaWitten
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Illuminating the brain: Neuroscientist Ilana Witten

Studying how brain cells communicate to enable learning, memory and socialization inspires Princeton neuroscientist Ilana Witten.

www.princeton.edu
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
2 years
Congratulations to this amazing team! @esylwestrak , @youngju_jo , @SamVesuna , @sussillodavid , @shenoystanford and all the others in the lab, for your dedication to this project over many years. (And don't miss the cover art hand-painted by none other than @esylwestrak herself…)
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@esylwestrak
Emily Sylwestrak
@esylwestrak
2 years
Paper Alert! I am thrilled to share our paper in @CellCellPress on cell-type-specific reward computations in the habenula! Along with @SamVesuna , @youngju_jo , @sussillodavid , @shenoystanford , and @karldeisseroth . Paper: Check out the thread 👇 (1/n)
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
1 year
Rest in peace, Dieter. Peter H. and I missed you in NYC in September. The more we discover going forward, about how these beautiful proteins work– and how they can reveal secrets of nature, and of ourselves– the more we look back to you...
@livesinchem
Lives in Chemistry
@livesinchem
1 year
† RIP Dieter Oesterhelt: The discoverer of #bacteriorhodopsin passed away on Nov. 28. He turned the light on in #biochemistry and paved the way towards #optogenetics and more with his group at the MPI for Biochemistry @MPI_Biochem as can be read in
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
6 years
Amazing body of work @XiaoWan38018817 (Xiao Wang) and @weallen1 (Will Allen)-- and the whole STARmap team... a joy to work with this constellation of stars! 😃
@weallen1
William Allen
@weallen1
6 years
And of course thanks to the mastermind @KarlDeisseroth
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
5 days
Thanks @ardemp - you have an amazing department @scrippsresearch - it was a whirlwind day of stimulating science and deep philosophical discussion with students and faculty alike… and so good to see you and star D-lab alum @liye_tsri again! Until next time…
@ardemp
Ardem Patapoutian
@ardemp
5 days
Standing room only for @KarlDeisseroth seminar @scrippsresearch . Breath of science is mind boggling: from ion channel structures, to optogenetic technologies, to understanding of the mind!
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
1 year
Two of my favorite people in the world, meeting each other for the first time! Peter Hegemann (new @theNASciences international member) and @michelle_monje ( @theNASciences Lounsbery Award winner). I feel as though I am in the room, thinking of these two and all we have shared...…
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
3 years
Next step from our structure team! following our initial ChR hi-res structure & anion-ChR structure, now the 3rd of the 3 main ChR types: pump-like ChRs! ChRmine’s shape stunned us: a trimer, unwound TM helix & more. Proud of our group & so lovely to see. @Yoon_Seok_Kim @emekato
@Yoon_Seok_Kim
Yoon Seok Kim
@Yoon_Seok_Kim
3 years
1. @karldeisseroth & I are excited to share, w/ @emekato et al: structure of a pump-like channelrhodopsin, ChRmine! complementing our team’s structures of the other 2 main ChR types
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
5 months
@SamVesuna @VivekBuchMD @CRodriguezMDPhD Here they are, at the launch! @CRodriguezMDPhD @VivekBuchMD +PaulNuyujukianMDPhD. I'm so fortunate to work with these amazing physician scientists. And thanks for all you are doing for our Human Neural Circuitry initiative, @samvesuna MDPhD. The future is bright with a team like…
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
2 years
Congratulations to our amazing channelrhodopsin structure team! One of the most exciting aspects of the past ~20 years has been our basic exploration of these light-gated microbial channels (including structural work together with this brilliant duo @yoon_seok_kim and @emekato ).
@Yoon_Seok_Kim
Yoon Seok Kim
@Yoon_Seok_Kim
2 years
9. I can’t thank enough my greatest mentor/advisor  @karldeisseroth ! –and of course my partner-in-crime  @emekato – for everything they’ve done. Big thanks also to  @K_E_kishi    @feynman1104   @efxbyrne @tbenst   @Drorlab   @kamakura1192MF  and everyone involved!
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
5 years
An early look at exciting work from @lovett_barron et al., with next-gen MultiMAP in zebrafish... the roles of specific cell types in survival-drive behavior change fundamentally, depending on the timescale. Congratulations team!
@lovett_barron
Matt Lovett-Barron
@lovett_barron
5 years
Our new study, and my first preprint, where we examine the role of hypothalamic neurons in the avoidance of homeostatic threats in zebrafish
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
3 years
So heartened by responses to Projections & its “weaving together…psychiatric knowledge, technology, and imagination”–“These together free him to write poetically...His narratives are always sensitive…an admixture of fact and fiction, reality and imagination, damage and desire."
@randomhouse
Random House Group
@randomhouse
3 years
. @ScienceMagazine raves about PROJECTIONS! "Karl Deisseroth’s…imaginative narrative flows effortlessly...There is a first love of reading and writing and hints of a literary imagination that draws on James Joyce and Toni Morrison."
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Karl Deisseroth
@KarlDeisseroth
2 years
The 2021 Lasker Public Lecture: Designed for the general public as well as our fellow scientists, and just sharing the joy: basic science discovery, through curiosity-driven exploration of the natural world... Thx to Peter for this Nike image from Berlin!
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
7 years
Dr. Christina Kim, 20th PhD from the lab, defending her thesis today, and importantly demonstrating a key life skill (going for distance).
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
3 years
BTW my editor, @randomhouse legend Andy Ward, also edited the incomparable Paul Kalanithi (When Breath Becomes Air). Paul worked in my lab @stanford on optogenetics. The world is small, after all... Take a look! and share as you like: 12/12
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
5 years
Thank you for the serene, lovely, and uplifting ceremony. @kyotoprize
@KyotoPrize
Kyoto Prize 京都賞
@KyotoPrize
5 years
🏅受賞者に京都賞メダル（20K）、ディプロマと賞金1億円が贈呈されました！ 🇺🇸先端技術部門 カール・ダイセロス博士 🇯🇵基礎科学部門 柏原正樹 博士 🇺🇸思想・芸術部門 ジョーン・ジョナス氏 #KyotoPrize #京都賞
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
1 year
Photo sent from a bookstore in Lisbon¬– an exciting day! But I hear there are somewhat more exciting events on people’s minds there today... #FIFAWorldCup Congrats to all my friends in Portugal. Condolences to my Swiss friends, but now, you have free time for literary pursuits…
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
4 years
congratulations to a fantastic team led by @ikauvar and @machado_ta ! looking forward to working with the simultaneity and scope of this approach on single trials, to probe brain-spanning dynamics in behavior.
@machado_ta
Tim Machado
@machado_ta
4 years
What would we learn if we could simultaneously measure neural activity across much of cortex at around cellular resolution? Check out our paper in @NeuroCellPress : Joint, collaborative, work with @IKauvar and mentors @wetzste1 and @KarlDeisseroth . (1/8)
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Karl Deisseroth
@KarlDeisseroth
3 months
Another authoritative review/perspective from a lab alum! this time Priya Rajasethupathy & her great team @RockefellerUniv . A deep literature dive with exposition on how recent innovation has advanced understanding of memory, spanning limbic, diencephalic & prefrontal circuitry.
@nakulyadav147
Nakul Yadav
@nakulyadav147
3 months
Delighted to share our latest perspective piece in @NeuroCellPress that I wrote with Andrew Toader and Priya Rajasethupathy  @RockefellerUniv to discuss models for how memory representations may gradually reorganize and stabilize across the brain. (1/4)
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Karl Deisseroth
@KarlDeisseroth
3 years
“Personal inspiration (like scientific discovery) can come from unexpected directions...” -Prologue (Projections). Helping psychiatric patients, & writing these stories, & investigating the brain, can be all somehow the same: just trying to find a place within, that is shared...
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Karl Deisseroth
@KarlDeisseroth
4 years
Triplesect! Congratulations @liefefenno @Yoon_Seok_Kim @feynman1104 @Kat_Evans_Neuro @kathycheungym @SamVesuna and the whole team. This will help expand the impact of all the pioneering single-cell RNAseq and connectivity work, allowing functional access to richly-typed cells.
@liefefenno
liefefenno
@liefefenno
4 years
Stoked! that our latest work is out @NeuroCellPress : a large viral toolbox for intersectional expression of molecular tools in cells defined by multiple parameters. 1/5
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Karl Deisseroth
@KarlDeisseroth
5 years
Congrats @weallen1 & team! Fascinating discovery: brainwide representation of survival drive (with single-spike resolution), that gates sensation & action. Bonus: demonstration that targeted optogenetics- as it is typically conducted- elicits naturalistic global brain dynamics.
@weallen1
William Allen
@weallen1
5 years
New paper out early today -- brainwide recording & optogenetic manipulation of how thirst regulates motivated behavior: Thanks to a great team, and Liqun Luo + @KarlDeisseroth !
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Karl Deisseroth
@KarlDeisseroth
6 years
Vilcek Foundation honors prizewinning MIT superstars/D-lab alums Feng Zhang ( @zhangf ) and Polina Anikeeva... and wonderful neuroscience colleague Sergiu ( @PascaStanford )! From all around the world, making this country a better place.
@Vilcek
The Vilcek Foundation
@Vilcek
6 years
Meet the winners of the 2018 Vilcek Prizes, honoring immigrant accomplishments in #biomedical #science and #architecture . Over the next few weeks, we’ll be featuring each prizewinner through videos, articles, and other content—stay tuned.
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Karl Deisseroth
@KarlDeisseroth
5 years
thank you @USConGenKansai ! The boys and I were honored to meet you. @KyotoPrize
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Karl Deisseroth
@KarlDeisseroth
4 years
Functional cell-type assignment may depend on the timescale of assessment. Fast timescales here reveal a distinct perspective on hypothalamic categorization in cells important for primary survival drives. Outstanding work as always @lovett_barron and team!
@lovett_barron
Matt Lovett-Barron
@lovett_barron
4 years
Our latest paper is out @NatureNeuro – we align neural population imaging with gene expression labeling, and find that multiple peptidergic cell types in the zebrafish hypothalamus jointly drive defensive behaviors to threats. 1/4
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Karl Deisseroth
@KarlDeisseroth
6 years
Amazing work...
@slinnarsson
Sten Linnarsson
@slinnarsson
6 years
1/n Today we celebrate publication of our mouse nervous system atlas by scRNA-seq! Fabulous work by Amit Zeisel, Hannah Hochgerner and many collaborators.
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Karl Deisseroth
@KarlDeisseroth
5 years
Thanks Hank! Terrific news... and interesting question... plenty of other psychiatrists in NAS and NAM, but I don't know of another in NAE...
@HankGreelyLSJU
Hank Greely
@HankGreelyLSJU
5 years
Great congrats to @KarlDeisseroth , new member of the Nat'l Acad of Engineering. I don't know if he's the only psychiatrist in the NAE but I'm betting there aren't many. (And no others who just talked to our federal judges law & the biosci seminar!)
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Karl Deisseroth
@KarlDeisseroth
3 years
Back in book-reading mode? Some great recent science autobiographies, none with more heart than this one: Entertaining! but the stories of his earliest experiments strike a deep emotional chord. He captures that vulnerable feeling, in humble first steps...
@DukeMedSchool
Duke University School of Medicine
@DukeMedSchool
3 years
Nobel Laureate Robert Lefkowitz tells an entertaining story in his memoir. “Everything reminds me of a story, and I’m always telling stories to my trainees.”
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Karl Deisseroth
@KarlDeisseroth
7 years
Promising work from Anto Bonci (at NIDA) and colleagues, bringing hope for drug addiction and abuse via optogenetics-guided clinical trials.
@HHMINEWS
HHMI NEWS
@HHMINEWS
7 years
Brain-altering magnetic pulses could zap cocaine addiction
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Karl Deisseroth
@KarlDeisseroth
2 years
Great to see you all @OptoGRC #OptoGRC2022 — and this whole community of amazing scientists … I think science makes us all the same height. Next time in 2024 under the towering guidance of @OferYizhar and the rest of the incoming chair / vice chair leadership!
@sjo09
Sheena Josselyn
@sjo09
2 years
The Masked Avengers of ⁦ @OptoGRC ⁩ (⁦ @denisejcai ⁩, ⁦ @tinakim_neuro ⁩, ⁦ @KarlDeisseroth ⁩). Funny I always thought he was taller.
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Karl Deisseroth
@KarlDeisseroth
2 years
Reflecting this holiday season on the current 6-month milestone, & remembering those earliest days of the June launch! I feel fortunate to have been able to connect with readers from all over the world in these virtual readings, and to hear so many interesting new perspectives.
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@AGiorgi19
Andrea Giorgi
@AGiorgi19
2 years
It was great to hear @KarlDeisseroth and @lyoun03 going through "Projections" and talking about #optogenetics , psychiatric cases and #autism in the today's virtual lunch discussion at @EmoryUniversity .
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Karl Deisseroth
@KarlDeisseroth
7 years
impressive work from Josh Huang and crew... defining brain cell type by communication properties indeed appears important: cf @TaliaLerner
@KepecsLab
Kepecs Lab
@KepecsLab
7 years
The transcriptional logic of cortical inhibitory cell-types, a Magnum Opus from my colleague Josh Huang
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Karl Deisseroth
@KarlDeisseroth
7 years
#kimye debut! from stellar co-first authors Tina Kim and Li Ye ( @omgtinakim and @liye_yeti ) (🤔relevant to prev. etymologies of #kimye ?)
@BenSaunders
Benjamin Saunders
@BenSaunders
7 years
Molecular and Circuit-Dynamical Identification of Top-Down Neural Mechanisms for Restraint of Reward Seeking
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Karl Deisseroth
@KarlDeisseroth
6 years
For the community: please do provide input and thoughts on the US NIH BRAIN initiative process as we start to approach the midway point-- follow the links here:
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Karl Deisseroth
@KarlDeisseroth
7 years
Congrats Matt! and kudos to the whole-brain-state gang in the lab, for their many years of dedicated and creative work...
@lovett_barron
Matt Lovett-Barron
@lovett_barron
7 years
our paper is out! evolutionarily conserved neuromodulation of brain state @KarlDeisseroth @AaronAndalman @weallen1
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Karl Deisseroth
@KarlDeisseroth
6 years
Thank you! and thanks to outstanding co-authors from neuroscience, chemistry, and chemical engineering-- Dr. Viviana Gradinaru, Dr. Jenny Treweek, and Dr. Kristin Overton-- great work laying out the principles of hydrogel-tissue chemistry and its variants
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Karl Deisseroth
@KarlDeisseroth
7 years
Thoughtful and valuable review on PFC in mouse and human from Marie Carlén ( @CarlenLab )
@meletislab
Dinos Meletis
@meletislab
7 years
What constitutes the prefrontal cortex?
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
8 years
A great scientist passes on. We'll miss you, Roger.
@HHMINEWS
HHMI NEWS
@HHMINEWS
8 years
Roger Tsien -- Nobelist's work illuminated the molecules of life:
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Karl Deisseroth
@KarlDeisseroth
5 years
High note: kids rushing the stage at the end! . And thoughtful comment on artistry from MIT prof Joan Jonas (pioneer of conceptual performance fusing video with her art) @ 1:57... Like artists, do scientists also conduct a dialog with the past & the future?
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The 2018 Kyoto Prize Presentation Ceremony highlights

Watch highlights from the Presentation Ceremony on 10 November 2018.

www.youtube.com
@KyotoPrize
Kyoto Prize 京都賞
@KyotoPrize
5 years
Watch highlights from the 2018 @KyotoPrize Presentation Ceremony on 10 November 2018! This year’s Prize goes to the following three individuals, 🇺🇸Dr. @KarlDeisseroth , 🇯🇵Dr. Masaki Kashiwara and 🇺🇸Ms. Joan Jonas. via @YouTube
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Karl Deisseroth
@KarlDeisseroth
2 years
Thank you Huda… wonderful conversation! and truly rewarding to see the book connecting so positively, not only with the literary review set, but also with eminent scientists and great people like you… ! Re-discovering how many scientists really love literature and language…
@Huda_Akil1
Huda A
@Huda_Akil1
2 years
Had such a great conversation with ⁦ @KarlDeisseroth ⁩ about his wonderful book “Projections”. What a compelling, moving, thought provoking book! Beautifully written, sharply observed, ambitious yet humble in the face of the challenge of interfacing psychiatry & neuroscience.
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Karl Deisseroth
@KarlDeisseroth
3 years
Still, scientists and artists alike know that the broken might describe the unbroken–whether in geology or genetics or poetry. And part of Projections is the telling of human stories through the throes of personal– or geopolitical– upheaval. Sometimes both at once. 4/12
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Karl Deisseroth
@KarlDeisseroth
7 years
Mountaintop view of Haifa, night and day
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Karl Deisseroth
@KarlDeisseroth
3 years
@michelle_monje the kids are very excited about "HDMI" 😀
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Karl Deisseroth
@KarlDeisseroth
3 years
A bit embarrassed (but glad) to learn to pronounce a few words I had read & written many times, but only heard in my head before, like “arboreal”😀… & honored to work with @natalienaudus & @MsKarenChilton , in key voice roles (thanks for joining this dynamic & unusual project!)
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Karl Deisseroth
@KarlDeisseroth
8 years
The Optogenetics Gordon Conference starts on Sunday! Program here: Theme: technology integration. Welcome all....
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Karl Deisseroth
@KarlDeisseroth
2 years
congratulations @OferYizhar ! wonderful recognition of your excellent work over the years...
@WeizmannScience
Weizmann Institute
@WeizmannScience
2 years
Congratulations to Prof. @OferYizhar for being elected as a member of the EMBO
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Karl Deisseroth
@KarlDeisseroth
2 years
Wonderful conversation with @PeterAttiaMD – writing Projections, medicine, human evolution, psychiatry, optogenetics, overcoming early life trauma, & insights into autism, mania & depression. Such an intellectually stimulating conversation! thanks Peter.
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#191 - Revolutionizing our understanding of mental illness with optogenetics | Karl Deisseroth...

“It turns out that behavioral states that mammals have, they can be cleanly broken apart into these features, and we could show that with optogenetics.” —Karl Deisseroth

peterattiamd.com
@PeterAttiaMD
Peter Attia
@PeterAttiaMD
2 years
New Podcast 191 — Revolutionizing our understanding of mental illness with optogenetics | Karl Deisseroth M.D., Ph.D. ( @KarlDeisseroth ) Watch/Listen to the full episode of The Drive today:
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Karl Deisseroth
@KarlDeisseroth
7 years
Congratulations Meaghan Creed and Raag Airan! Excellent essays too. Science PINS Prize: … …
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Karl Deisseroth
@KarlDeisseroth
2 years
It was great working with you, @machado_ta and @ikauvar (both on some of the original methods and on this review). Brain-wide activity readouts now allow global exploration for principles of brain function, which can be brought to causal testing. An exciting time for discovery...
@machado_ta
Tim Machado
@machado_ta
2 years
@ikauvar @KarlDeisseroth and I discuss these questions in our new review in @NatRevNeurosci ! (2/6)
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Karl Deisseroth
@KarlDeisseroth
4 years
Thanks Kay! Looking forward to the symposium-- Many close friends, lab alumni, great collaborators, and fantastic scientists from Salk, UCSD, and beyond will be there...
@kaymtye
Kay M Tye PhD
@kaymtye
4 years
16 hours away...!!! @UCSDNeuro @SDForScience @salkinstitute
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Karl Deisseroth
@KarlDeisseroth
4 years
Congratulations to a great team! and a wonderful seven-year collaboration between our group and @zhenanbao 's lab in Chemical Engineering. Initial step into a new domain spanning chemistry and genetics within living systems. So many ideas now emerging...
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Karl Deisseroth
@KarlDeisseroth
4 years
Congratulations Dr. Allen! As a graduate student Will built new technologies and made many remarkable discoveries- studying the intact brains of behaving mammals with optogenetics, widefield optics, and brainwide physiology. I’m lucky to work with such amazing people. 😀
@weallen1
William Allen
@weallen1
4 years
Thank you to @SfNtweets @MartyNemko and my amazing advisors @KarlDeisseroth and Liqun Luo!
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Karl Deisseroth
@KarlDeisseroth
2 years
Congratulations Xiao!!!
@ChemistryMIT
MIT Chemistry
@ChemistryMIT
2 years
Congratulations to Professor Xiao Wang ( @WangXiaoLab ), who has been named a 2022 Packard Fellow by the @PackardFdn ! #PackardFellows
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Karl Deisseroth
@KarlDeisseroth
6 years
Come for the fiber photometry workshop, stay for the monster squirrels!... both need scale bars though to fully appreciate...
@estef_azevedo
Estef Azevedo
@estef_azevedo
6 years
Great FP workshop @KarlDeisseroth Lab @Stanford ! Thanks Karl for the input and resources and Maisie Lo for putting all of this together! The only reason I’m posting the picture of this squirrel because he/she was huge 😂
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Karl Deisseroth
@KarlDeisseroth
7 years
SfN Young Investigator Awardee from D-lab: Kay Tye:
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Karl Deisseroth
@KarlDeisseroth
2 years
Beautiful work on how features are used to recall memories & the prefrontal->hippocampal projections ( @Nature ; Priya Rajasethupathy’s team @RockefellerUniv ). Read the whole thing & parallel frontal->hippocampal projection work from @sohallab @CellCellPress
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
3 years
If I helped a little bit, it was worth writing the book just for that @michelle_monje ... your job is harder than mine…
@michelle_monje
Michelle Monje🎗️
@michelle_monje
3 years
I re-read this passage many times this past week....neuro-oncology is hard.
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Karl Deisseroth
@KarlDeisseroth
3 years
Caring for those with severe mental illness has been a constant thread in my work, starting with 8 years of dedicated medical training & psychiatry residency, followed by inpatient & outpatient care for the past 17 years @stanfordmed . I don’t usually speak or write about it. 3/12
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Karl Deisseroth
@KarlDeisseroth
3 years
Congratulations Tina! students and postdocs: Tina is a great mentor, and expert in just about everything… join her lab if you get the chance…
@tinakim_neuro
tina kim
@tinakim_neuro
3 years
I’m SO stoked to share that I’ll be starting my lab @UCDavisCNS this fall! It’s hard to express the amount of pure joy and gratitude I feel, but this picture gets close :) Taken the weekend after signing during a climbing trip to one of our favorite crags near Davis.
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Karl Deisseroth
@KarlDeisseroth
2 years
Next-generation hydrogel-tissue chemistry: clearing-assisted tissue click chemistry (CATCH). Congratulations Li & team! @liye_tsri @scrippsresearch
@liye_tsri
Li Ye
@liye_tsri
2 years
Excited to share new paper @CellCellPress . Led by Zhengyuan Pang @ScrippsGradPrgm , collaboration w/ Ben Cravatt, CATCH is a chem-bio innovation to allow imaging of drugs in tissue. This "mission impossible" only happens with the incredibly collaborative @scrippsresearch . 1/3
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Karl Deisseroth
@KarlDeisseroth
3 years
"...But this time, with the rustling of the leaves, unsettling intimations had come, borne high and kitelike on the same ghost wind... and there was a feeling of openness, of vulnerability, that was not entirely positive." –Projections, Chapter 5. "The Faraday Cage"
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Karl Deisseroth
@KarlDeisseroth
3 years
This book has been incubating in many ways for 20 years. Projections is unusual– not easily captured in a few characters¬– except I could begin by saying that universal inner experiences of humanity may sometimes be revealed, in the chaos and tumult of emergency psychiatry. 2/12
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Karl Deisseroth
@KarlDeisseroth
2 years
Dutch/Turkish/German/Italian/Japanese/Hungarian/Korean/French/Chinese/Spanish/Russian & other translations in-print or on the way. I’m so moved by readers posting feelings, thoughts, images… Grateful to resonate with both scientists & literary critics. Sticking with my day job…
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Karl Deisseroth
@KarlDeisseroth
3 years
A deeper perspective on the day: … Thanks to 12 yrs of basic cellular/molecular & clinical #DIPG research @stanford from @michelle_monje & her team "His hearing improved...he no longer slurred his words" "He could walk better...and use his hands to text"
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Facing death, Kansas student goes to Super Bowl, inspiring a team of players, parents

“I can’t imagine what that feels like at any age, no less 21,” says one former Chief. “He’s facing death with bravery. He is not afraid of it.”

www.kansascity.com
@LisaWardspeakup
Lisa Ward
@LisaWardspeakup
3 years
@michelle_monje THIS ONE is for YOU! @Shermanator_42 , @jayfeely , @lt4kicks @ryanbresette needed @JaceWard3 healthy enough to travel to gift the trip of a lifetime! CarTcells working hard to give DIPG patient 1 more days for big dreams! #Tough2gether
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Karl Deisseroth
@KarlDeisseroth
1 year
@marcduque3 very interesting set of findings!-- congrats @marcduque3 @EngertLab @MishaAhrens and colleagues... (and hat tip to @AaronAndalman , Vanessa Burns, @lovett_barron , @KanakaRajanPhD and the whole team from that brain-wide optical screen in passivity behavior)
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Neuronal Dynamics Regulating Brain and Behavioral State Transitions

Brainwide imaging in zebrafish and network modeling reveal that switching from active to passive coping state arises from progressive activation of habenular neurons in response to behavioral...

www.cell.com
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Karl Deisseroth
@KarlDeisseroth
1 year
thanks @__Matt_Carter__ ! It's so great to see the stories and neuroscience working together in the university/academic setting as well. And– for even more accessibility– paperback launch day is 2 wks away (March 28) under new cover art from Random House & Viking. Preview here:
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@__Matt_Carter__
Matt Carter
@__Matt_Carter__
1 year
My Williams College capstone course for Neuroscience seniors just finished reading Projections by @KarlDeisseroth . We complemented the book with classic optogenetic papers by @OferYizhar and @syk_net , an amazing educational experience. So much material for rich conversations.
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Karl Deisseroth
@KarlDeisseroth
7 years
Congrats @weallen1 --- and the whole team --- it will be hard to top this with your tweet #2 !
@weallen1
William Allen
@weallen1
7 years
New paper, first tweet: why do thirsty mice drink water? Collab with Michael Chen and Laura Wilke. #ThirstTRAP ?
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Karl Deisseroth
@KarlDeisseroth
3 years
Interesting to see international titles coming in, since the diverse connotations of “Projections”, in terms of exposing forms that lie within, don’t easily translate (for example in Dutch “Projecties” apparently didn’t work). Grateful to @Miek_cam for the insight of “Inzichten”.
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Karl Deisseroth
@KarlDeisseroth
3 years
Projections is for anyone (non-scientist or scientist, art-lover or artist) pondering those feelings that make us human, broken and unbroken as we all are¬– as individuals and as humanity– by joy and defeat, peacemaking and violence, parenting and loss. And mental illness. 8/12
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Karl Deisseroth
@KarlDeisseroth
2 years
Launch day in French! thanks to @DulacLab and @BrunetLab for reassurance on the translation...
@dunod_editeur
Dunod, Armand Colin, InterEditions et Maxima
@dunod_editeur
2 years
À travers les histoires de personnes souffrant de maladies mentales, @KarlDeisseroth  nous éclaire sur la nature de nos propres émotions dans 📕 "Les fils tressés de nos sentiments", disponible dès aujourd'hui 👉 #science #livre #nouveaute #librairie
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Karl Deisseroth
@KarlDeisseroth
2 years
Really enjoyed meeting with your students, Gisel! … so interesting to see how Projections works as a teaching tool…
@GiselFl03872212
Gisel Flores-Montoya, PhD
@GiselFl03872212
2 years
Loved having @KarlDeisseroth for a class Q&A @CarletonCollege last week! His book Projections has been a source of great discussion for my students these past two terms! The case studies discussed add depth and realism to our discussions on mental health disorders and treatments!
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Karl Deisseroth
@KarlDeisseroth
2 years
Proiezioni comes out on February 22, @silviopina ! thanks for the query-- hope you like the translation...
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@KarlDeisseroth
Karl Deisseroth
@KarlDeisseroth
3 years
@silviopina Yes it's Proiezioni! Cover design is happening now. Sounds like that title works well in Italian...
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Karl Deisseroth
@KarlDeisseroth
3 years
In each story, threads from literature and imagination, from human history and prehistory, and from modern neuroscience, can all be found interwoven with the connections from psychiatry (which alone, I think, would not be enough to show the full picture). 6/12
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Karl Deisseroth
@KarlDeisseroth
2 years
"Piercing the professional armor"–yes, that sounds right! Thank you Dr. @BSchildkrout , and all the doctors & scientists & patients sharing feelings on Projections. Beyond the literary reception, it means even more to really connect with people who know and live this every day.
@michelle_monje
Michelle Monje🎗️
@michelle_monje
2 years
Just out in March from the psychiatric times, an excellent review of @KarlDeisseroth 's book Projections. "The book is not only a joy to read, but also a compelling educational experience. I recommend it to every 21st-century psychiatrist."🧠📙
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Karl Deisseroth
@KarlDeisseroth
5 years
Greatly enjoyed my visit... and seeing your innovative approaches to bringing engineering tools to psychiatry... much building for the future at Oxford.
@OxPsychiatry
Oxford Psychiatry
@OxPsychiatry
5 years
Congratulations to ⁦ @KarlDeisseroth on ⁦ @KyotoPrizeOx ⁩ - and for taking the time to visit us at the Warneford. KDs innovations inspire us all to increase our research power and ambitions ⁦ @OxHealthBRC ⁩ #MentalHealthAwarnessWeek
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