Teachers! Parents!
It is legal and perfectly welcome to email scientists asking for a PDF of their paper.
Until all papers are free, please RT to make this more widely known. And fyi, scientists don't get the $$ from sales of papers so all it costs us is 1 minute of time!
Last week I was invited to sign a letter offering support for David Sabatini, organized by current & former lab members. Universities considering hiring him have asked for this.
I will not sign.
There was no option to provide a more nuanced response, so I will elaborate here 🧵
15 years ago I taught myself how to code.
Now there are cancer patients walking around Vienna alive because of my lab's software,
@cellprofiler
. Researchers did this study without us, just downloading my software and using it. I couldn't be prouder!
2 years ago, everything was going great in my mid-career lab.
Making a choice to reduce stress and prioritize my health turned out to have ripple effects - my colleagues, family, and friends are reaping the benefits, as am I.
I tell my story in
@eLife
Told my girls that
@CarolynBertozzi
won the Nobel prize and that it’s extra cool because usually men win it.
8yo: “That’s weird because most people don’t really remember the men who got it, just the women. Like Marie Curie… I mean, I can’t even name any men who won.” 😂
If budgets for NIH and NSF increase dramatically...
could we talk in advance about not using the money to train more PhD students and postdocs, and instead figure out how to systematically encourage staff scientist positions? Ideas beyond just individual PI decisions?
Impact score 10! 😮🎉
I only applied for this major grant because an NIH Program Officer went out of his way to encourage me.
How many don't flourish in their careers because someone isn't looking out for them? How can YOU take this role for someone, esp. those less privileged?
My kid (reading big science words aloud over my shoulder): how do you know all this stuff?
Me: Well, I went to school til I was 30, so....
My kid: How often were you held back?!
Every year, most of them give up the dream of being a professor because there are not enough openings. Why is it more a tragedy for someone to “lose” their lab than for any of these, who are committed to making science a more equitable place, to never have the chance?
I want to be clear that my success is not evidence that he did not break policies. It is not evidence that the lab had a professional, supportive environment for all. It does not prove that he treated men and women equally in the lab.
The good news: we have 4 papers accepted or moving in that direction at great journals
The bad news: the fees to make them all open-access is $40k
We haven't minded paying $3-10k from time to time but this flood all at once is really hitting me and making me question everything.
Finally, David names me in his lawsuit, in a list of his women alumni who have succeeded in academia - I and six others are presented as “obvious evidence that contradicts the finding that women were disadvantaged”. The logic here is appalling.
3 years of work... the JUMP-Cell Painting Consortium has now released the world's largest public Cell Painting dataset!
117,000 compounds, 13,000 overexpressed genes, 8,000 gene knockdowns, w/images and extracted profiles 🤯
Data @ Cell Painting Gallery:
So I will not be signing this letter, and my missing anonymous signature will not likely be noticed. But I can say: so many faculty out there work hard everyday to create healthy lab cultures. There are hundreds of talented postdocs looking for an opportunity to launch a lab.
We don’t know how much better/easier our careers could have been if David’s lab had been a professional, science-focused workplace, equally supportive of all demographics. And an equal environment might have yielded more women on this list.
Delightful 😠
I've had enough of big-name scientists leveraging their fame to exploit others.
Is science well served by one dude taking 30 postdoc salaries from the funding ecosystem & producing a few high-tier papers/year?
Leaving human wreckage in his wake?
There's an impact of family leave you might not have noticed.
(unless you've gone through it yourself as a PI - a person responsible for raising grant funding to pay your lab)
I spent 30% of my startup funds to fill the funding gap caused by the birth of my babies.
If you see me give a talk about my lab’s research, all animated and without using any notes, you might think I have a natural knack and love for public speaking. I *do*, but it wasn’t always that way. 🧵
I do not believe that some lab members attesting to a wonderful experience in a lab means anyone can in good conscience ignore the outcomes of official proceedings, or of those who had a bad experience.
@oldenoughtosay
This awesome mom forgot to pack a spare outfit to carry on the flight, which is why my toddler strutted to meet her uncle wearing her long sleeved shirt as pants and her coat as a top. You’re thinking “a shirt works as pants?” …it really does not 😌
Top tips for those attending a professional conference for the first time!
1. It's ok if you only understand the first few minutes of a talk (when the topic is being introduced). Absorb what you can, then tune in for the next talk. Many times it's the speaker at fault, not you.
Hey, college Anne! You should major in computer science, which no one ever mentioned as a possibility despite the fact you've aced every math/science class & your dad's an engineer.
It'll help you in your deep learning research at Harvard/MIT later.
Also, ditch your boyfriend.
@gallantlab
@benbfly
@aexbrown
@manlius84
@nature
I'm not angry and my name is not Ann.
You should have included the statement "We will not be releasing data promptly. We will release the data publicly after publishing N additional studies."
It's astonishing to me that you seem to genuinely think this suits Nature policy.
I just have to wonder how a supportive letter signed by some lab members is relevant, in light of 3 institutions concluding policies were broken, and in the absence of any route for dissenting lab members to provide input.
People often ask me how I managed to transition from being a biologist to leading an entirely computational group.
Here is the story of my shift: "Bridging Domain and Data"!
Open-access article in the new journal Patterns
@Patterns_CP
Parents with kids under five, it may help to have a concrete example of “it gets easier”…my 8 & 10yo made breakfast lunch and dinner for us today because I had a…tough week, and I think my heart will burst 💕🥰🥰🥰
Pharma spends millions of $$ for *each* screen where they test millions of compounds to find those impacting a given protein’s activity.
What if we could just... look up the right compounds in a catalog w a computational query? 🤯🤯🤯
Preprint alert from Carpenter-Singh lab! 🧵
I’m cooking up a startup! The first startup idea to meet my criteria in over ten years, since Recursion.
We will focus on targeting tumor ecosystems using machine learning and data science. Please get in touch if you might like to be involved!
The letter is to be anonymous, just reporting the number who signed, and some basic demographics. It is a google form that doesn’t track addresses, allowing anyone to “sign” the letter multiple times. There is no way to register as declining to sign. It’s unscientific.
I was the only female postdoc and I quickly learned to navigate the lab’s bro culture. I avoided being the target of mean comments, but I regret not standing up for those who were targeted. And a policy-breaching relationship is at issue in this case, not just lab climate.
The Broad Institute just surpassed 1,000,000 COVID tests completed! 😮😮😮
They now process 1 out of every 20 tests in the USA, with 24h turnaround.
Congrats to these amazing researchers for keeping all of us healthier!
@broadinstitute
Dafna Bar Sagi now low-key threatening research faculty: "There are people probably on this call who came to NYU [ got hired ] with some controversy around them, and they know that sitting on this call."
Do you want to attract computational biologists to your project?
Do you want to attract computational biologists to your department?
With a dozen colleagues around the globe, we present "A field guide to cultivating computational biology"!
Read on!
1. make a Mastadon account even if you don’t want to use it yet.
2. put your new handle in your Twitter bio.
3. run a tool like this to export the people that you follow.
Even if you’re not ready to learn Mastodon, these 3 steps allow you to get up and running later.
Discovering new medicines is a critical, shared human endeavor.
I am delighted to announce *10* major pharmaceutical companies & 3 non-profits have come together to accelerate drug discovery by creating the world's largest public Cell Painting dataset 🌟
Postdoc opening in Boston!
Your expertise in machine learning, statistics and/or data science can be splendidly applied to drug discovery and disease research at my lab at Harvard & MIT (Broad Institute).
Whitehead found policy violations. HHMI concurred and three senior MIT officials recommended revoking his tenure as well. There’s a civil lawsuit over whether the process was fair, just to be sure. These have far more information in hand than the rest of us.
US citizens or permanent residents from an under-represented group!
You can contact any NIH-funded researcher you admire & suggest applying for this supplement to join their lab! High school thru postdoc/faculty. Many, like me, are happy to host! Pls RT
Took 1-8y off science for family during your postdoc or faculty position?
Contact NIH funded labs to see if they will write a reentry for you (I will!).
Please RT these little-known supplements:
An incredibly heartwarming event! Recursion named a building after me!
Bonus: Recursion’s HQ is near a shopping area so ppl can also see a Cell Painting art display, and a robot that mimics the Cell Painting assay all day long, to interest the local community in science.
It was a special time at our
#SaltLakeCity
HQ on Friday, July 28th! We celebrated three influential figures in Recursion’s journey with new buildings and labs named in their honor:
🌟Dean Y. Li, MD, PhD, Recursion co-founder & board member, President of
@Merck
Research Labs
Can leaders please just eliminate programs like this??
If more time is spent applying than is funded for the winner, it’s a NET NEGATIVE for scientific progress.
DoD Breast Cancer scores are out... good score and checked payline for why we were rejected. LESS than 1% funded. Not a typo! 1 of 163 funded. That is 162 labs that wasted significant time.
That said, I was not surprised to see the investigation (which did not involve me) found “issues of particular concern” relating to lab climate. The lab environment was unprofessional when I joined in 2003. I trust those who report that it worsened since then.
Our essay in Nat Cell Bio:
"Bringing computation to biology by bridging the last mile"
We argue to shift resources/rewards towards creating user-friendly software to bridge computation and biology-it yields huge returns!
@shantanuXsingh
Free author link:
The publisher sent me this book (that’s a first!)
I’m only a few pages in but
@DrSidMukherjee
is so lyrical:
“Millions of his T cells had brushed past his melanoma every day and just moved on, bystanders that had turned their faces away from a cellular catastrophe.”
US citizens or permanent residents from an under-represented group! High school thru postdoc/faculty.
You can contact any NIH-funded researcher you admire & suggest applying for this supplement to join their lab! Many, like me, are happy to host!
Thousands of biologists rely on CellProfiler, maintained by 1 person.
Without doubt, investing in open source software is the most catalytic thing philanthropists can do.
Not space travel, btw.
Machine learning experts!
90-day competition now open to identify nuclei in images. My lab worked *really* hard preparing this data, help us out & win $$! Please RT 💚
🌟 Virtual data science internship in biomedicine! 🌟
4-6 months, flexible start date
Open to undergrad/grad students, postdocs, even those employed - all you need are strong computational skills and a desire to apply them to biology! & permission to work in USA for duration.
👇
Realized in a gender-in-science chat today a HUGE advantage of being a female academic with your own lab:
Apart from owning your own business, it's one of the few careers where you can almost completely choose whom you work with, and can create the work culture you want.
Took 1-8y off science for family during your postdoc or faculty position? Contact NIH funded labs to see if they will write a reentry for you. Please RT these little-known supplements:
My 7 year old said she wanted to interview me about my job last night. I had a delightful 'woman in science' proud moment and when we sat down she said the assignment was to interview someone who makes mistakes in their work, and how does it help them be more successful
Judging accusations like these wrongly in either direction is a horrible outcome. But why does anyone need to re-judge these accusations at all? Without all the information at hand, just on the basis of a support letter?
A recent PNAS study found that high-performing women have one thing in common: they have a tight-knit circle of other women who help them with “gender-specific private information and support.
@Refinery29
Article source:
Grant proposal writing pro tip:
Once I've finished drafting, I go back and read the RFA (grant call) again, all the way through. No matter how well I think I know it, I always realize a few key things I ought to add to the proposal.
It is happening!!
Postdoc positions now open to join the Schmidt Center at Broad Institute in Boston. Advance ML *and* biomedicine.
You can just apply, or propose particular labs you're interested in. Pick mine! We have all the best data! 🦠
People often ask how I manage so many ongoing projects: we discuss 50+ collaborations each year so it is a lot to track! I reveal our lab's secrets in this blog post:
I hope my story helps others critically evaluate the ‘bigger is better’ mindset in science (thanks
@BerondaM
for the b-index, which influenced my decision!)
I’m feeling vulnerable sharing my story! Thanks to eLife for encouraging me to tell it and running this career series.
I’m old enough to remember the budget doubling which yielded the postdocalypse. Let’s not increase student/postdoc positions by 20% without evidence of demand also going up 20%.
@gallantlab
@aexbrown
@manlius84
@nature
I've no skin in this game but you are blatantly not abiding by Nature's policy. Your motivations for breaking their rules are irrelevant. If you intended to keep the data private for one year this should have been stated to reviewers and in the article.
Now is a great time to remind folks of the existence of several Slack channels for PIs/researchers:
@Mid_Career_PI
@NewPI_Slack
@FuturePI_Slack
@GradSlack
These don’t replace the broad engagement here but offer career support without trolling.
Come do a paid internship in Data Science at the Broad Institute!! With me! Full/part-time, up to 6 months.
Undergrad/grad students, postdocs, even those employed are eligible - all you need are strong computational skills and a desire to apply them to biology!
@broadinstitute
The MLSC is excited to announce that applications are now open for the 2020 Internship Challenge, High School Apprenticeship Challenge, and the Advanced Analytics/Data Science Internship Program.
First, I want to be clear that those organizing are people I feel fondly towards, due to our shared experiences together growing as scientists. No one pressured me to sign and I appreciate that.
Got 20 minutes?
Check out my new video talk, "Image Analysis for the Modern Biologist: why and how"!
Brought to you by NIH
@NIGMS
, including Paul Sammak
@FeelingFisky
All I wanted were red 💯s at the top of my papers, got sucked into grad school, and now I’m stuck leading biomedical research at Harvard and MIT.
Wow, this is super misleading, as if academics are routinely curing things and handing drugs over for pharma for them to profit with little further investment.
Folks, this is huge!
Biologists count on open-source software everyday and yet it is so hard to find funding to support engineers to maintain and develop it. Way to go CZI!! 🎉🎉🎉
At the
@EMBL
#ImageAnalysis
conference,
@thefreemanlab
announced CZI is supporting the work of 3 Imaging Software Fellows who are building critical and widely-used open-source tools: scikit-image,
#ImageJ
/ Fiji, and CellProfiler.
@wfithian
What’s interesting to me is all of the men critiquing her writing this in the comments. Women don’t get the luxury of career advice dispensed over the water cooler artisanally, and help others by writing in plain language how the system works. And are then called careerist.
ImageJ and CellProfiler: image analysis friends forever!
Follow this protocol to figure out how to use them together.
We also describe circumstances where you might prefer to use ImageJ instead of CP, as a guide.
Supported by
@COBA_NIH
Have a PhD but career interrupted? Contact any researcher you admire who has an NIH grant and suggest applying for a re-entry supplement. Many, like me, are happy to host. Please RT!
PSA: the people judging your proposals are probably old and definitely busy.
Give them decent font sizes, white space, headings, bullet points, pictures. And no data figures shrunk to oblivion.
I’m finding in the past few years, other reviewers on papers are ALWAYS more harsh than me, that reviewers of my own papers expect too much for the venue I’m submitting to, and I see papers published in venues that seem a notch too “low”. 🧵
Curious about applying deep learning for difficult bioimage segmentation tasks but don’t know where to start?
We wrote a review to help you find user-friendly software for precisely this challenge!
Available here (Lucas et al):
@_aaronmiles
@mmitchell_ai
Do NOT pay for COBRA right when leaving a job! You have 60 days to decide whether to take it *retroactively*. If you get new insurance by then and have no health troubles you’re good! If something major happens & COBRA would help, you can sign up on day 60 & it covers you!