Siddhartha Mukherjee @DrSidMukherjee Twitter profile

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

I am going off Facebook and Instagram & trying to delete my accounts. I cannot support an organization that pretends to support free speech, but actually enables hate speech. Neutrality in the midst of violence is violence. Bye bye Facebook. Bye bye Instagram. No more posts.

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

If we had N95 masks for wide distribution, hand hygeine, isolation, quarantine and tracing, could we still bring this to a halt? YES, yes, yes. A trillion dollar loss, rising unemployment... all because we have no leadership. Any questions?

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Siddhartha Mukherjee

@DrSidMukherjee

3 years

1/n Long thread, but of crucial importance. The COVID-19 situation in India is as dire as can be. And it is not just THEIR problem, as long as virus circulates in the world, it becomes EVERYONE'S problem. We live in a global society; viruses don't respect national borders.

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Siddhartha Mukherjee

@DrSidMukherjee

3 years

Ok, so 24 hours post vaccination, arm soreness gone. No fevers or myalgias. And no.. I have not turned into an alligator.

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Siddhartha Mukherjee

@DrSidMukherjee

3 years

Repeat after me: 1. The vaccine doesn't cause blood clots. 2. The vaccine doesn't cause brain fog. 3. Doesn't cause chronic fatigue. 4. The vaccine doesn't cause kidney failure. 5.The vaccine doesn't affect the heart/intestines.6. The vaccine doesn't put people on ventilators.

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Siddhartha Mukherjee

@DrSidMukherjee

3 years

1/n The anecdotal stories about the number of people in India getting COVID after AZ or Covaxin need to be addressed.

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Siddhartha Mukherjee

@DrSidMukherjee

2 years

So here it is … Blue, gold and red (via Kiki Smith) … out on Oct 25th. Pre-order if you’d like I’ll post reading events next …

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

Watch this before you decide to abandon social distancing, masking, and isolation and quarantine. Please take the message seriously.

AJ+

@ajplus

4 years

He fought and survived Ebola, and now he's on the frontline of #COVID19 in NYC. This is a day working in the ER, as told by Dr. @Craig_A_Spencer .

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

Oh, and I am PROUD that Kamala Harris has chosen to embrace her identity as the daughter of immigrants, and of Jamaican-Indian parents. It makes me feel as if I (finally) belong in this country. My 2 daughters embrace their Indian-Chinese-Scottish-Irish identity.. THEY ARE PROUD.

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Siddhartha Mukherjee

@DrSidMukherjee

2 years

Just finished typing the last word in my new book. !!!!!!!! Now editing, photos, references etc etc and a 6 month fact check… ready ???

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Siddhartha Mukherjee

@DrSidMukherjee

3 years

Amazing news from Moderna!! Now with two vaccines, we just need to VACCINATE!! A logistical problem that won’t be easy to solve — but at least we are moving forward. That’s why science matters !!!

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Siddhartha Mukherjee

@DrSidMukherjee

3 years

My mom !!! A covid hero... ventured out by herself and is vaccinated

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

BUY US TIME. BUY US TIME. THERE ARE DRUGS BEING TESTED. HOSPITALS ARE OVERWHELMED. HEALTH CARE WORKERS ARE DYING. #BUYUSTIME

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Siddhartha Mukherjee

@DrSidMukherjee

3 years

So extraordinary proud to announce that THE GENE: an Intimate History was nominated for an Emmy award. Ken Burns and Barack Goodman — thanks for your work on this book

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Siddhartha Mukherjee

@DrSidMukherjee

3 years

Why on earth are we pretending that the pandemic is over? It is not. We need to vaccinate, vaccinate, and continue precautionary measures. Europe is experiencing a THIRD wave. Please... let's be thoughtful.

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

Downplaying the dangers of a deadly virus is an insult to science. "Don't be afraid of COVID" is also an insult to decency. Tell that to the families that have lost their loved ones, or to the frontline workers who are very very legitimately afraid..

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Siddhartha Mukherjee

@DrSidMukherjee

2 years

Any early thoughts from early readers of THE SONG OF THE CELL ? Critiques welcome. October 25th… if you want a copy fast, grab one

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Siddhartha Mukherjee

@DrSidMukherjee

3 years

And btw, if you put a gun to my head and asked “can vaccinated people transmit C19”? I would say “no”. I’m not sure, but I have a DPhil in viral immunology. There. I said it.

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Siddhartha Mukherjee

@DrSidMukherjee

3 years

I’m waiting for my turn at the vaccine. Will tweet EVERY symptom and side effect with complete honesty. I’ll be extra cautious, but I think vaccines are the only way forward

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

1/n Please stop harassing me about maths. First, I am attacked by the Christian Right for being Muslim (I am not). Then, I am attacked by the Hindu right for not giving credit to Hindu mathematics. Sure ! I can read SANSKRIT. I know the history of mathematics as well as anyone

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

My piece on viral loads, health care workers, antibody/serology monitoring and past lessons from other viruses for the New Yorker

How Does the Coronavirus Behave Inside a Patient?

We’ve counted the viral spread across peoples; now we need to count it within people.

www.newyorker.com

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Siddhartha Mukherjee

@DrSidMukherjee

3 years

1/n Please pay attention, please. I'm afraid that we are falling behind in this COVID race. There are at least 4 variants of concern: variants arising in London, Manaus, Japan and South Africa.

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

This is the level of bigotry that’s been unleashed. FYI: I’m not Muslim, but that’s hardly the point. Arab mathematics enabled us to understand exponentials, which allows us to track epidemics. It also allows us to understand the exponential of idiocy that exists

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Siddhartha Mukherjee

@DrSidMukherjee

3 years

1/n As we watch NEW strains of COVID emerge, it becomes even more important to get vaccinated. New strains can only emerge as the virus multiplies within hosts. More hosts = more strains. It is a number's game.

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Siddhartha Mukherjee

@DrSidMukherjee

6 years

HUGEST honor to bring THE Gene: An Intimate History to PBS as a three part documentary with @KenBurns . I am thrilled to join Ken in this project to illuminate the past and future of genetics. This will be a pathbreaking production !

PBS Announces KEN BURNS PRESENTS THE GENE: AN INTIMATE HISTORY, New Collaboration with Siddhartha...

PBS announced KEN BURNS PRESENTS THE GENE: AN INTIMATE HISTORY, a new three-hour documentary executive produced by Ken Burns, will premiere over three nights in Spring 2020 on PBS.

www.pbs.org

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

Kamala Harris !!! No other words. Joy. Joy. Hope.

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

I am in the process of adding 2-3 chapters to The Emperor of All Maladies for 2020. So twitterati.. what should absolutely be included in prevention, detection and treatment? Obviously, immunotherapy, the role of obesity, the success of HPV vaccines. Other major thoughts ?

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Siddhartha Mukherjee

@DrSidMukherjee

5 years

So so so honored to be among the Guardians 100 most influential books of the 21st century. Wow. And at #32 , Emperor even made it to the top 50.

The 100 best books of the 21st century

Dazzling debut novels, searing polemics, the history of humanity and trailblazing memoirs ... Read our pick of the best books since 2000

www.theguardian.com

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Siddhartha Mukherjee

@DrSidMukherjee

3 years

How can I NOT be flattered that @harari_yuval has THE GENE on his bookshelf. I am an admirer, and I reviewed his book, Homo Deus for the NYT.

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Siddhartha Mukherjee

@DrSidMukherjee

3 years

My mother got vaccinated today. Oh what a HUGE relief. She’s still going to mask and keep social distance, but it’s the most personal sign of light at the end of this tunnel...

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Siddhartha Mukherjee

@DrSidMukherjee

3 years

GOT MY FIRST SHOT OF VACCINE (Moderna). I won’t post a picture of my deltoid 😂

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Siddhartha Mukherjee

@DrSidMukherjee

5 years

Wow ! What an honor ! The GENE among the 75 best science books of all time, by @BillGates @reidhoffman and others . Thanks a trillion

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Siddhartha Mukherjee

@DrSidMukherjee

3 years

For everyone fretting about the "long term effects" of the COVID vaccines.. consider the effects of COVID infection. Chronic fatigue, brain fog, blood clots, mental health, cardiac damage, kidney damage etc.

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Siddhartha Mukherjee

@DrSidMukherjee

3 years

And btw, two hours post Moderna vaccine, I feel PERFECTLY fine. Not a single side effect.

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Siddhartha Mukherjee

@DrSidMukherjee

3 years

Kamala Harris: "Superheroes are not just in your imagination. They are nurses and doctors and scientists. They are vaccine makers."

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

So the lockdown was mandatory. Business closure was mandatory. Why can’t we : make 1. Masks mandatory 2. Distribute them freely or provide ONE set of instructions to make 3. Provide one set of decontamination instructions. CDC ANYONE ?

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

I know it’s Gregor Mendel’s (20 July) birthday because it’s one day before mine (21st). Also auspicious because the Oxford vaccine was created using genetic methods !

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

3:44 am.... Still working through Covid papers to see what the solution might be. Tomorrow I’ll post about social distancing and masks again. If you can’t handle repeated entreaties for research on testing/protection, please block me But I’m going to work through the night

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

Working on writing a step-by-step guide on how to reopen the economy with (a) immune and viral testing (b) widespread use of masks and gloves (c) rapid access to new drugs (d) isolation of the vulnerable

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Siddhartha Mukherjee

@DrSidMukherjee

5 years

And folks, please do NOT switch to keto diets ALONE without the PI3 kinase inhibitor, or without medical supervision or evidence. In our paper, leukemia ACCELERATES with keto diet alone. Please follow the data from our study

Suppression of insulin feedback enhances the efficacy of PI3K inhibitors

Nature - Glucose–insulin feedback can reactivate PI3K in tumours treated with PI3K inhibitors, reducing therapeutic efficacy, but this effect can be reduced by using drugs or diet to suppress...

www.nature.com

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

Here is what I am working on. We need a TABLE to show the various tests for COVID, the turnaround time, cost, the scale, the specificity and sensitivity, and how they could be used to open a city or a private business. IN ONE TABLE. Everything on a single table. Stop confusion.

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Siddhartha Mukherjee

@DrSidMukherjee

3 years

7/n 4. Vaccine raw materials. The US needs to approve a "waiver" so that vaccine manufacture can continue. Leadership counts. Send letters, pleas, to whoever you know. India manufactures the bulk of vaccine for the world. A vaccine holdup in India has ricocheting consequences.

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

Police officers stationed outside the subway handing out masks... infection rates down; deaths nearly down to zero. Way to go NYC.

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Siddhartha Mukherjee

@DrSidMukherjee

6 years

I'm thinking of giving up Twitter. I can't handle the news cycle. Trying to write about medicine, cancer, dying, healthcare, genetics .. but Trump generates so much mad news that it's like a constant smokescreen.. perhaps it's worthless trying to resist it

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Siddhartha Mukherjee

@DrSidMukherjee

3 years

AND DO NOT, DO NOT, DO NOT PLEASE SPREAD FALSE RUMORS. The vaccines have been vetted by the FDA. I know we don't know long term effects, but young and old are dying. We are doing the best we can.Please help stop fake news.

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

This is a chilling reminder of what it is like in the frontlines. "America is not prepared". The wealthiest country cannot protect its healthcare workers with PPE ? A mask that costs 50 cents to make ?

Danielle Belardo, MD

@DBelardoMD

4 years

This is chilling. A nurse on the front lines in Chicago tried to wear her own N95 to work while caring for COVID pts (when it wasn’t supplied for her) & she was told by management she would not be allowed to. She quit her job. @DrMarthaGulati @CMichaelGibson @boback @netta_doc

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

1/n Listen: this is getting into irritating territory. If you want to re-open business, scientists have offered a plan.

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

In NYC, everyone outside on the street, & everyone in the hospital, SHOULD BE WEARING A MASK. N95 for hospital workers. And gloves. Surgical masks for essential workers. Everyone else: stay at home. Cuomo: get the people what they need to be safe. Medicines R coming. #BUYUSTIME

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

The documentary "The Gene: An Intimate History" -- with Ken Burns at the helm -- starts tonight on PBS 7/8c. If you are stuck at home, why not educate yourself on modern genetics, and what a virus is (a genome packaged in a coat)?

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Siddhartha Mukherjee

@DrSidMukherjee

6 years

This is a terrible story for Harvard. Asian Americans (like my own children) are consistently rated "lacking in personality" (!!! ) whatever the subjective hell that means. Anti-Asian discrimination is not widely discussed, but is omnipresent.

Harvard Rated Asian-American Applicants Lower on Personality Traits, Suit Says (Published 2018)

Personal ratings brought down Asian-American applicants’ chances of being admitted, according to an analysis filed by a group suing the school for bias.

www.nytimes.com

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Siddhartha Mukherjee

@DrSidMukherjee

3 years

This is a perfect study for a global alliance (including WHO) to launch. We really, really need to establish whether the two vaccines in India (Covaxin and Covishield/AZ) are effective. Do they protect against severe disease? It would take a month to do the study..

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Siddhartha Mukherjee

@DrSidMukherjee

2 years

Just received the cover of my new book.. and yes, I love it. I can't share it yet (oh, rights etc). But I managed to squeeze my favorite color into it. 😄

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Siddhartha Mukherjee

@DrSidMukherjee

6 years

I loved this story... sometimes, news of our progress against cancer is hidden in the most unlikely of sources (wedding announcements) ... and when you find it, the story can move you to tears

Love Not Lost: Two Childhood Cancer Survivors Marry at St. Jude (Published 2018)

They first saw each other 30 years ago under desperate conditions. Life went on, but they never forgot each other.

www.nytimes.com

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

HOW CAN THIS POSSIBLY BE TRUE ? We can’t get our own health care workers N95 masks while several MILLION are sold to foreign buyers ? Can someone please investigate?

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Siddhartha Mukherjee

@DrSidMukherjee

5 years

From the first bone marrow transplants to CAR-t therapies ... an incredible scientific legacy. But can we afford these new treatments ? Are they really drugs ? My latest in the New Yorker

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Siddhartha Mukherjee

@DrSidMukherjee

3 years

2/n This is, or was, a moment of historic importance for the US/ Biden administration to show leadership and solidarity. Recall the legacy of WW2 that established America as a world leader. Compare that to the leadership today.

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

1/2 I’m not going to reveal who wrote this, but it’s one of my scientific & personal idols who redefined cancer : “Human creativity is best defined as joining two fields that have not been joined before. All those who are truly creative have “mastered the art of non-expertise”

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

1/n So the Trump brigade has now come after me. I won't answer their insults individually.. but a. Do I tell my cancer patients to be "very afraid". Ridiculous comparison. But yes, I tell them to take reasonable precautions against a deadly disease and don't disparage science.

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

Yet another paper arguing that mandatory masking protects against COVID... you CANNOT do a randomized trial, so this is a natural experiment. BUT THE EVIDENCE KEEPS ACCUMULATING ...

Unmasked! The effect of face masks on the spread of COVID-19

Confronted with a novel, aggressive coronavirus, Germany implemented measures to reduce its spread since March 2020. Requiring people to wear face masks in public places has, however, been a subject...

cepr.org

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

1/n The AZ vaccine adverse effects are seriously concerning. First, since public money flowed into the project through OWS, we need to have access to the data to figure out what happened. If needed, this should be escalated (legally)

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Siddhartha Mukherjee

@DrSidMukherjee

3 years

Still confused why Moderna's vaccine EUA is being evaluated by the FDA Advisory Committee on Dec 17th while the world is the throes of a pandemic... is the virus taking a winter break? Any thoughts on why we are waiting for 2.5 weeks ?

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Siddhartha Mukherjee

@DrSidMukherjee

3 years

OK, I know it's not pretty, or perfect, but it is the best I could do.... apologies to perfectionists.

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

The Gene: an Intimate History – @PBS documentary by @KenBurns based on my book will air in the UK this Thursday and Friday! 8:30pm, channel 91 on Freeview. From Mendel to gene therapy (filmed before the pandemic, but highly relevent to vaccine development and tracing...)

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

Reading the Times today and looking at the severe cases with YOUNG deaths: nurses, therapists, caregivers, doctors. We should really really think about viral dose and it’s relationship to severity. Happy to be proved wrong...but these people really need PPE

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

Even if a mask’s protection is 50 percent, or a reduction in viral load, it is effective. We’ve been saying this since March!!!! (And please don’t quote the badly powered, non-compliant studies that say otherwise... I’ve heard them all)

Masks May Reduce Viral Dose, Some Experts Say (Published 2020)

People wearing face coverings will take in fewer coronavirus particles, evidence suggests, making disease less severe.

www.nytimes.com

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

You can watch Part 1 of the documentary here. The Gene: An Intimate History

The Gene | Dawn of the Modern Age of Genetics | Episode 1 | PBS

Part One interweaves present-day stories with the discoveries of pioneers in genetics.

www.pbs.org

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Siddhartha Mukherjee

@DrSidMukherjee

6 years

What my father's death taught me about physiology, cities and nations in 2017 (long read ; be warned )

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

Please take this seriously. We need a social movement to mask everyone

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Siddhartha Mukherjee

@DrSidMukherjee

6 years

At long last, in Nature, from our lab and Lew Cantley's lab.. can diet be used as a drug ? For centuries, it was the ONLY drug... why not reinvent diet ? For cancer patients ?

Suppression of insulin feedback enhances the efficacy of PI3K inhibitors

Nature - Glucose–insulin feedback can reactivate PI3K in tumours treated with PI3K inhibitors, reducing therapeutic efficacy, but this effect can be reduced by using drugs or diet to suppress...

www.nature.com

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

I haven’t slept for two nights triaging cancer patients and reading papers on how to deal with their infections. Go find someone else to troll about their “hairstyle”. What does it take to have a civil conversation about a global crisis ?

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

1/2 And one thing MISSING from the conversation (I used to be a virologist by training) is VIRAL LOAD. Large volume exposure (huge viral load) may be different from low viral load. That MAY be why ER docs, and young nurses in China may be severely affected

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Siddhartha Mukherjee

@DrSidMukherjee

3 years

I got a thousand replies to my questions, but not any that I needed/wanted. 1. I know the lab data... do we have HUMAN data on AZ/Covaxin vaccine effectiveness against B1618 etc in India? 2. And why aren't any of these studies in PEER REVIEWED JOURNALS?

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Siddhartha Mukherjee

@DrSidMukherjee

3 years

4/nThe most immediate requirements are: 1. Liquid oxygen in tanks. The requirement is about 40-50,000 metric tons temporarily. Some of it has been procured from Germany, Japan and the M.East. There is a govt. tender to procure these from any supplier, including ones in the US.

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Siddhartha Mukherjee

@DrSidMukherjee

3 years

Ten hours after vaccine and I feel GREAT. Arm a little sore but nothing else. Mostly, feel thankful. No fever, no myalgia.

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Siddhartha Mukherjee

@DrSidMukherjee

3 years

And yes, please please get vaccinated. This is not an anti-vaccination manifesto. Quite the opposite: GET VACCINATED. WEAR MASKS. ISOLATE. But also, let's get real world data now, for India, and for the world.

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Siddhartha Mukherjee

@DrSidMukherjee

3 years

What would it take to make this image viral ?

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Siddhartha Mukherjee

@DrSidMukherjee

2 years

Our homemade Rangoli... best wishes for Diwali. May this be a year of light and global vaccination. Special points to anyone who can guess all the spices.

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

Just as predicted: viral load predicts mortality. Now the question is: does viral inoculum (how much virus you get at exposure) predict severity or infectiousness ?

How Does the Coronavirus Behave Inside a Patient?

We’ve counted the viral spread across peoples; now we need to count it within people.

www.newyorker.com

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Siddhartha Mukherjee

@DrSidMukherjee

3 years

3/n Now, let's get practical. I've spoken to several people on the ground in India, and here are the immediate needs in terms of priorities. Several field hospitals are being set up, but there are dire infrastructural needs.

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

OK.. if people promise to watch the second part of the Gene: An Intimate History tomorrow on PBS (8 pm/7c), I promise to live tweet about making it.... deal ?

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

Spent the afternoon making Bengali shrimp curry. It was, to be honest, more satisfying than dreaming up about-to-fail experiments in the lab.

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

And remember that viral load MIGHT predict disease severity. So... think of every way you can to decrease the dose of the poison ... less contact, more masking, more washing

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

Or to put it another way: viral testing can get us to identify those who might be or get sick. Antibody/immunity testing might identify those who can get back to work (assuming no "re-infection"). Got to do BOTH.

How Does the Coronavirus Behave Inside a Patient?

We’ve counted the viral spread across peoples; now we need to count it within people.

www.newyorker.com

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

1/1 There are 4-5 extremely promising candidate drugs in development for COVID-19/SARS Cov-2. We need to BUY TIME to allow these drugs to be tested in (hopefully) randomized studies.

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Siddhartha Mukherjee

@DrSidMukherjee

6 years

With my mom after consuming a giant bowl of spicy chicken curry !

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

Can people retweet this widely with indignation ? What in the world is wrong with the system ? We put our own nurses at risk, while others buy masks that are in our country ? Can we please investigate ? Retweet ?

Siddhartha Mukherjee

@DrSidMukherjee

4 years

HOW CAN THIS POSSIBLY BE TRUE ? We can’t get our own health care workers N95 masks while several MILLION are sold to foreign buyers ? Can someone please investigate?

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Siddhartha Mukherjee

@DrSidMukherjee

3 years

Important editorial on the very dangerous B1617 strain. Note: the vaccines in the US are likely protective against this strain. Please get vaccinated

Opinion | Covid’s Deadliest Phase May Be Here Soon (Published 2021)

A new, more transmissible variant could devastate countries without vaccines.

www.nytimes.com

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

Once again, it’s becoming clear that using an antiviral drug EARLY IN COVID patients (Remdesivir is an example) is better. This is the case with virtually every respiratory virus. We can change the course of this disease !!!

Gilead Announces Results From Phase 3 Trial of Remdesivir in Patients With Moderate COVID-19

www.gilead.com

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

To all international folk trying to watch The Gene: An Intimate History... we are trying to negotiate international broadcasts but your local TV networks don't want to carry it... Sorry. So request, retweet, ask your networks. PBS licenses are easier than..um..The Crown.

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Siddhartha Mukherjee

@DrSidMukherjee

3 years

6/n 3. Dexamethasone and inhaled steroids are apparently in supply. But we are checking to see if adequate supplies are available in pharmacies.

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Siddhartha Mukherjee

@DrSidMukherjee

2 years

The first review of my new book, The Song of the Cell. Almost the end of the road. Putting in last few corrections/changes....phew !!

THE SONG OF THE CELL | Kirkus Reviews

A luminous journey into cellular biology.

www.kirkusreviews.com

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

I don’t think it’s a coincidence that the young people with severe disease are doctors, nurses, and schoolteachers. Some data here would help

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

It is time to run a trial of EARLY rx with Remdesivir (or antibodies) in NON-hospitalized COVID patients. That would invert the paradigm: if you have a risk factor (diabetes, obesity) then TEST EARLY, TREAT EARLY. That would make it safe to open the economy.

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

1/n I had an eye splash from a high viral load HIV positive patient while doing a lumbar puncture in the 1990s. Had a mask, but wasn't wearing goggles (my fault). Was on triple therapy for a month - the most nausea I have ever had; lost 10 pounds. Did not seroconvert thankfully

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Siddhartha Mukherjee

@DrSidMukherjee

2 years

About to launch book tour (London; Edinburgh) .. and also about to fade from exhaustion … CBS Sunday tomorrow morning at 9 EST …

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

A second lockdown would devastate millions of lives. Cmon people, dont violate the 3 Cs - crowds, closed spaces and close contact settings. And please please wear masks, esp in 3C settings

As Social Distancing Wanes, Cuomo Warns of Another Lockdown (Published 2020)

Sports bettors are shifting to stocks. Brazil’s daily death toll is now the highest globally, and Peru is one of the world’s hot spots.

www.nytimes.com

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Siddhartha Mukherjee

@DrSidMukherjee

3 years

5/n 2. Military grade oxygen concentrators and refillable tanks. This is one example:

Military Grade PSA Based Oxygen Plant - Onsite Gas Generation Systems | Medical Oxygen Generator

Military Grade PSA Based Oxygen Plant: The Hi-Tech’s Medical oxygen generator allows users to generate their own oxygen for their medical-grade requirements

www.hitechgas.com

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Siddhartha Mukherjee

@DrSidMukherjee

3 years

HUGELY intriguing trial on humans with in vivo delivery of gene editing... and without many adverse effects. GREAT NEWS for VOR -- gene editing for leukemia -- that enables a new possibility of a cure !!

CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis | NEJM

Transthyretin amyloidosis, also called ATTR amyloidosis, is a life-threatening disease characterized by progressive accumulation of misfolded transthyretin (TTR) protein in tissues, predominantly t...

www.nejm.org

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Siddhartha Mukherjee

@DrSidMukherjee

4 years

1/n IMPORTANT: Can someone please publish a homology map of all the beta coronaviruses that have been circulating in human populations ? Why? Because at least 2-3 papers suggest that there is pre-existing immunity, at least CD4/8 cell mediated, because of cross reactivity.

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Siddhartha Mukherjee

@DrSidMukherjee

3 years

DING DONG

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