Sasha Gusev @SashaGusevPosts Twitter profile

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Sasha Gusev

3 months

I've written about race, genetic ancestry, analyses of large biobanks, and human history I'll summarize the key points here 🧵:

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Sasha Gusev

@SashaGusevPosts

5 months

I know it's awkward, but if you're in a relationship and it's getting serious, you should talk to your partner about running their dissertation through a plagiarism checker.

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Sasha Gusev

@SashaGusevPosts

4 months

So this is pretty typical of the low-information content you get from the genetic racists. The majority of this post is just blather but there is one (1) specific claim about genetics: that the molecular genetic contribution to IQ keeps going up every year. This is false. A 🧵:

Steve Sailer

@Steve_Sailer

4 months

@SashaGusevPosts When read closely, it's about out how Charles Murray is more right than the Conventional Wisdom about IQ. But he’s still a Witch! This is another attempt to fight back against rampant Science Denialism while not being accused of witchcraft yourself.

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Sasha Gusev

@SashaGusevPosts

4 months

The racists in Stancil's replies have started appealing to "scientific consensus". So let's look at what the consensus of *high-quality evidence* is on genetic racism. A 🧵:

Will Stancil

@whstancil

4 months

Here's something that is absolutely critical to understand: the race science creeps, the Sailer types, work hard to give the impression that genetic researchers and other scientists agree with them. But they don't. The real scientists ALSO think Sailer and co. are racist goons

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Sasha Gusev

@SashaGusevPosts

1 year

A 🧵 on some of my intuitions/priors about the genetics of complex and molecular traits in humans (i.e. what I think of as typical), largely motivated by GWAS/QTL studies over the past decade [citing papers with nice figures where possible]

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Sasha Gusev

@SashaGusevPosts

2 months

Unpopular opinion (just look at the QT's) but nearly every "dogmatic, outdated, and misleading" claim about IQ listed here is either objectively accurate or heavily debated dispute within the field itself. Let's take them one at a time:

Rolf Degen

@DegenRolf

2 months

"Senior psychology majors knew very little about the topic of intelligence, but more importantly, were grossly misinformed and had overwhelmingly negative views of the field."

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Sasha Gusev

@SashaGusevPosts

11 months

The recent paper of [Clark 2023 PNAS] finds that social status correlates across family lineage in a way that is consistent with genetic transmission. Is genetic transmission the only model that can produce this pattern? Let's take a look ...

The inheritance of social status: England, 1600 to 2022 - PubMed

A lineage of 422,374 English people (1600 to 2022) contains correlations in social outcomes among relatives as distant as 4th cousins. These correlations show striking patterns. The first is the...

pubmed.ncbi.nlm.nih.gov

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Sasha Gusev

@SashaGusevPosts

5 months

Ackman about to uncover a thousand papers saying "Here we present a novel transformer architecture that significantly outperforms the state of the art on multiple established benchmarks"

Daniel Litt

@littmath

5 months

Ackman (apparently) doing a review for plagiarism by all MIT faculty. A bit weird but honestly seems fine to me—much better than going after only faculty whose politics you dislike. Would be much better to look for more substantive research misconduct, though.

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Sasha Gusev

@SashaGusevPosts

2 months

My plan is to stop talking about IQ as soon as IQ'ists stop talking about genes and evolution. So any day now ...

Andrew R. A. Conway, Ph.D.

@AndrewRAConway

2 months

Oh look, a Harvard professor who has never published a paper on the topic of intelligence, has never taught a course on the topic on intelligence, weighs in on the meaning of IQ. Dude, Gould did it, 40 years ago. He was wrong then, you are wrong now. Bored.

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Sasha Gusev

@SashaGusevPosts

21 days

It pains me to see facile critiques of GWAS on here from our clinical/biostats friends while the many actually good reasons to be critical of GWAS get little attention. So here's a thread on what GWAS does, what critics get wrong, and where GWAS is genuinely still lacking. 🧵:

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Sasha Gusev

@SashaGusevPosts

4 months

Sailer tends to disappear whenever he is addressed directly so I'm not hoping for a response. Maybe in a day we'll get another story about sports or movies. But here are a few more unaddressed errors in the whole race/genes/IQ/outcomes project:

Sasha Gusev

@SashaGusevPosts

4 months

@Steve_Sailer 1: Can you explain the fact that in local ancestry analyses genetic variation is nearly identical (~0.95, with a confidence interval up to 0.97) between African and European segments. That's pretty remarkable similarity isn't it?

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Sasha Gusev

@SashaGusevPosts

1 month

I’ve seen critiques of the poor methodology and cherry-picking in The Bell Curve but I haven’t seen much about the absolutely deranged fever dream of predictions about the coming decades in its closing chapters. It has been 30 years, so let's review. 🧵:

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Sasha Gusev

@SashaGusevPosts

7 months

The Bell Curve may be the single most damaging modern popular science work. An entire generation of hiring managers came of age believing (incorrectly) that IQ is (a) highly heritable and (b) highly predictive of job performance.

Richárd

@krichard1212

7 months

A new study on IQ and job performance dropped. Sackett's claims are vindicated, AND they fail to find support for the claim that IQ predicts better in "high complexity" jobs.

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Sasha Gusev

@SashaGusevPosts

4 months

The shell game they play is: (1) claim that there's *lots* of evidence out there; (2) present one or two sketchy correlations based on bad methods; (3) promise that the better results are just around the corner. In the real world, their position keeps losing. /fin

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Sasha Gusev

@SashaGusevPosts

4 months

Nate Silver misinterpreting a simple regression analysis was not on my bingo card.

Nate Silver

@NateSilver538

4 months

This is weak. The study finds SAT scores predict college grades better than HS grades whatever you control for. Being from an elite high school predicts college grades better than either, but that's not something you'd want to use in admissions if your goal is to promote equity.

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Sasha Gusev

@SashaGusevPosts

9 months

@thejb_stan Seems like they had some other issues too

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Sasha Gusev

@SashaGusevPosts

4 months

@NAChristakis A tenured prof at Yale commenting on the tweet of a tenured prof at Harvard commenting on a billionaire ex-Enron exec's commentary on two Harvard Crimson articles about an advanced math course. Their conclusion: kids these days have it too easy, not like we had it!

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Sasha Gusev

@SashaGusevPosts

4 months

@whstancil Nobody is voluntarily getting into a Twitter space with Ian Miles Cheong just for a tax cut. At that point you're a true believer.

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Sasha Gusev

@SashaGusevPosts

5 months

@kareem_carr Someone else pointed this out, but it's likely she was copying sections of stock methods text into a draft to rewrite later and then not sufficiently rewriting them. This would also explain cribbing someone's acknowledgements. It's not good and students are warned against this.

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Sasha Gusev

@SashaGusevPosts

11 months

This is a great example of misinformation perpetuated by political moderates. Molecular genetics has blown a huge hole through most of these heritability estimates but "behavior is equal parts nature and nurture" is such an appealing claim that it has captured popular opinion.

Matthew Yglesias

@mattyglesias

11 months

@Alicoh1 This is one of these these things that qualifies as a hot take on Twitter but where laypeople’s estimates in surveys are very close to what experts have published.

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Sasha Gusev

@SashaGusevPosts

4 months

So we've gone from 51% to 20% to 14% as the field has learned how to apply these methods more precisely and address confounding. Researchers that raised concerns of environmental confounds and stratification were proven right, and it's unlikely that we've resolved all the issues.

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Sasha Gusev

@SashaGusevPosts

4 months

So the technical point is flat out wrong. And this style of argument mirrors a general trend. Charles Murray has been promising that his views will be vindicated in "just five years" since 1994!

evo psych googling

@evopsychgoogle

5 years

charles murray, prophesying the arrival of evidence vindicating the bell curve 1994: in three or four years we'll see whos right ;) 1995: five years from now 2014: probably less than a decade 2019: within a few years... 2049: (moments before death) any minute now

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Sasha Gusev

@SashaGusevPosts

5 months

A few thoughts on the recent set of papers torture testing genomic deep learning for predicting individual-level gene expression [ , , ]. First a brief summary 🧵:

Sasha Gusev

@SashaGusevPosts

6 months

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Sasha Gusev

@SashaGusevPosts

4 months

I've written up a "crash course" on population genetics parameters useful for thinking about recent selection, heritability, and group differences (as part of a longer write-up on these concepts). I'll summarize the key points here 🧵:

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Sasha Gusev

@SashaGusevPosts

3 months

Funny to see the PCA vs UMAP debate start to take on a culture war angle. In reality, the latter simply doesn't identify basic population structure correctly. Here's an example with three-way admixture: admixed individuals get mapped almost arbitrarily.

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Sasha Gusev

@SashaGusevPosts

4 months

When Howe et al. finally employed a proper within-family analysis their estimate of the heritability was ... just 4% (with a tight error bound). That's right, the *entire* common genetic contribution to educational attainment, a major status-driving factor, is a rounding error.

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Sasha Gusev

@SashaGusevPosts

4 months

Again?! How does this keep happening!

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Sasha Gusev

@SashaGusevPosts

4 months

@opinonhaver This is the one statue pfp guy that's good! It's very confusing

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Sasha Gusev

@SashaGusevPosts

3 months

Before going all in on My Struggle, these clowns should probably learn the difference between "adoption" and "adaptation"

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Sasha Gusev

@SashaGusevPosts

6 months

@DanRiffle -- A conservative is a liberal who's been mugged -- A liberal is a conservative who's been arrested -- A Molotov cocktail wielding anarchist is a conservative who got a speeding ticket

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Sasha Gusev

@SashaGusevPosts

3 months

😬 ... The bug here is also nightmare fuel: largest data point in a histogram gets dropped silently because of rounding error ( )

Treat binwidth as approximate to avoid dropping outermost datapoints by mwaskom · Pull Request...

This PR changes the interpretation of the binwidth parameter in histplot and objects.Hist. With the previous implementation, floating point errors could cause the largest datapoint(s) to be silentl...

github.com

Sergi Valverde🌍

@svalver

3 months

Wow. A bug in the Seaborn data visualization software hid many CD=1 papers, leading Park et al to incorrectly conclude that disruption in science and technology is declining (top histogram), while it is not ( bottom histogram). @VincentGinis

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Sasha Gusev

@SashaGusevPosts

2 months

I see this claim that "stereotype accuracy" is highly replicable pop-up a lot. You really have to dig for the underlying data but here's an example: the "stereotype" is income/poverty rates by race, most people get it wrong, and it still somehow gets summarized as "accurate". 🤷

Alex Tabarrok 🛡️

@ATabarrok

2 months

@jessesingal Also "Stereotype accuracy is one of the largest and most replicable effects in all of social psychology." @PsychRabble

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Sasha Gusev

@SashaGusevPosts

4 months

@NAChristakis Calling out unseriousness is constructive. Every day I interact with the brightest college kids I've ever seen, who are desperate to make the precarity of academia work for them. Then log on here to see the most comfortable academics and billionaires chastise them for being soft.

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Sasha Gusev

@SashaGusevPosts

4 months

Fast forward to 2023, using hundreds of thousands of people from the UK Biobank, Williams et al. [] ran a battery of analyses to refine a high-quality IQ estimate. The heritability ... 0.20 (with very precise error).

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Sasha Gusev

@SashaGusevPosts

4 months

@BrandonLBradfor Sailer: "Here's a racist take that just fell out of my head, I'm literally making this up!" 100k Sailer fans: "Can you prove him wrong with data? Show me statistics that what he just made up is wrong. I am incapable of independent thought!" [*repeat for decades*]

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Sasha Gusev

@SashaGusevPosts

4 months

The first study in 2011 into the heritability of IQ using molecular genetic methods found moderately high estimates 40-51%. But this approach was flawed technically (estimator bounds and population structure) and conceptually (environmental confounding).

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Sasha Gusev

@SashaGusevPosts

4 months

But this doesn't address the conceptual issue of environmental confounding. For that, Howe et al. used a large-scale within-family analysis, which does a much better job of isolating the genetic component from shared environment. Their estimate of the heritability ... 0.14!

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Sasha Gusev

@SashaGusevPosts

6 months

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Sasha Gusev

@SashaGusevPosts

9 months

@jdcmedlock Fun fact: both quiet quitting and quiet cutting were prominently featured in the film Office Space (1999), also quiet embezzlement and quiet arson

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Sasha Gusev

@SashaGusevPosts

7 months

I'm writing a molecular perspective on heritability, behavior, (and eventually) race/ancestry, group differences. The idea is to start with what we've learned from genetic data and then work backwards to what we used to know from classical studies.

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Sasha Gusev

@SashaGusevPosts

4 months

Predictably, a response is not coming. The whole point is to use the guise of "data" and scientific inquiry to mainstream the same old gutter racism. These people do not take their own project seriously and neither should anyone else.

Sasha Gusev

@SashaGusevPosts

4 months

@Steve_Sailer @Mexican_Hat1 Any response here?

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Sasha Gusev

@SashaGusevPosts

1 year

What techniques are folks using to help trainees get to a first draft (especially for their first paper)? Here's my lab handbook page on writing, but the tips are mostly technical. What's the big picture advice for going from an outline to a full paper?

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Sasha Gusev

@SashaGusevPosts

4 months

@NAChristakis This whole discussion is remarkably unserious and is itself evidence that it used to be much easier to coast through academia into Chaired tenure on vibes and hunches alone.

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Sasha Gusev

@SashaGusevPosts

4 months

Steve Hsu has been arguing that a 60% accurate genetic predictor is just around the corner since 2011, and last year declared himself vindicated! (As we just saw, the GWAS heritability of IQ is <14%, it cannot possibly reach 60%)

Sasha Gusev

@SashaGusevPosts

1 year

@hsu_steve I'm confused, neither of these things happened by 2016 and the latter has still hasn't happened even with the EA GWAS of n=3M

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Sasha Gusev

@SashaGusevPosts

4 months

This trend is even more extreme for Educational Attainment, an easier to study trait with more practical relevance. Initial studies had estimates of 22% heritability which decreased to ~15% as better methods and more representative cohorts were applied.

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Sasha Gusev

@SashaGusevPosts

4 months

On genetics/race/behavior, over a hundred population geneticists denounced Nick Wade's A Troublesome Inheritance (a sort of genetic racism catechism). Their conclusion: "there is no support from the field of population genetics for Wade’s conjectures"

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Sasha Gusev

@SashaGusevPosts

4 months

On innate group IQ differences. Three preeminent psychologists wrote a detailed explainer on the state of the research. Their conclusion: it is "based on a weak brew of unexamined intuition and sketchy empirical evidence".

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Sasha Gusev

@SashaGusevPosts

1 year

The NIH has a program for early career investigators to serve on study sections and participate in grant review. I highly recommend this to anyone applying for funding, getting to see the review process is absolutely worth your time!

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Sasha Gusev

@SashaGusevPosts

1 month

"please listen closely as our menu items have recently changed" is a good example of how society has normalized corporate lying

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Sasha Gusev

@SashaGusevPosts

1 year

A 🧵 on educational attainment (EA) GWAS and evidence of extensive confounding from multiple recent studies (much more than for disease traits). FWIW: I’m not a behavioral geneticist and I welcome disagreement on this.

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Sasha Gusev

@SashaGusevPosts

4 months

I’ve seen quotes from David Reich’s “Who We Are and How We Got Here” passed around with the insinuation that it is secretly supportive of racist and hereditarian theories, even though it directly criticizes such views. It's worth looking at what Reich actually wrote: 🧵

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Sasha Gusev

@SashaGusevPosts

4 months

David Reich, a preeminent population geneticist, went on to write an entire book on the topic of genetic ancestry. His conclusion: "the ancient DNA revolution ... is fueling a critique of race ... Mixture is fundamental to who we are"

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Sasha Gusev

@SashaGusevPosts

5 months

An academic discussion that really bugs me on here is about "administrative bloat". Which is in stark contrast to most faculty saying that they're drowning in administrative responsibilities. The problem is most people don't know how university revenue and spending works ..

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Sasha Gusev

@SashaGusevPosts

9 months

A 🧵 on two fascinating recent papers looking at trans-ancestry genetic effects in admixed individuals, which have changed the way I think about complex traits. [Hou et al. Nat Genet, ; and Hu et al. biorxiv, ]

Leveraging fine-scale population structure reveals conservation in genetic effect sizes between...

An understanding of genetic differences between populations is essential for avoiding confounding in genome-wide association studies (GWAS) and understanding the evolution of human traits. Polygenic...

www.biorxiv.org

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Sasha Gusev

@SashaGusevPosts

3 months

Explaining twitter to a friend:

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Sasha Gusev

@SashaGusevPosts

6 months

polygenic👏score👏means👏cannot👏be👏compared👏across👏populations [Figure modified from Ding et al. ]

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Sasha Gusev

@SashaGusevPosts

2 months

This is pretty striking. Take one single cell experiment, split it into random "batches", correct the batches, and look at change in nearest neighbor cell rank. Big changes (not good)!

Pall Melsted

@pmelsted

2 months

In this preprint with @sindri_e we compared seven widely used methods for batch correction of single cell RNA-seq data. We found that all but one of the methods introduce batch effects when there are none. 1/N

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Sasha Gusev

@SashaGusevPosts

4 months

@sam_kamin @whstancil I'm not trying to convince Sailer or his yahoos. I think it's important for normal people to be aware of the consensus high-quality evidence in the field. I agree there are always downsides to engagement.

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Sasha Gusev

@SashaGusevPosts

4 months

@Steve_Sailer 1: Can you explain the fact that in local ancestry analyses genetic variation is nearly identical (~0.95, with a confidence interval up to 0.97) between African and European segments. That's pretty remarkable similarity isn't it?

Sasha Gusev

@SashaGusevPosts

7 months

@Steve_Sailer @maxt2047 @Chimpin88865810 @Classicist9999 @EvanGiangrande @BehaviorGenetic @StevePittelli @Race__Realist @thebirdmaniac @jayjoseph22 @smaceachern2 @AdamRutherford @ent3c @Evolving_Moloch @RebeccaSear @ed_hagen @C_Kavanagh This has already been done, multiple papers have looked at European variant effects in admixed individuals and they are essentially identical. All you have left is continuing to pretend these studies don't exist:

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Sasha Gusev

@SashaGusevPosts

20 days

"Eugenics can work: All u need is to plant humans in a common garden, cull the lowest performing humans, keep the environment fixed forever, and ignore widespread pleiotropy with other traits. Checkmate libs!"

Razib 🥥 Khan 🧬 📘✍️📱

@razibkhan

20 days

u need to know SNPs for editing but not selection. All u need for selection is heritable variation. R = h^2 * S where response is due to narrow sense heritability times selection

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Sasha Gusev

@SashaGusevPosts

7 months

A few excellent recent papers on important and often misunderstood population parameters in genetics. A short 🧵:

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Sasha Gusev

@SashaGusevPosts

9 months

For students sending cold emails: I'm begging you to please not use ChatGPT to expand/formalize. I will take three sentences about why you want to join the lab + a CV over a five paragraph essay every single time. I'm drowning in five paragraph essays.

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Sasha Gusev

@SashaGusevPosts

5 months

The DEI conversation on here feels like it's from another planet. The biggest "DEI experience" I've had as faculty was being reminded to think about bias in the hiring process and intentionality/structure in interviews. And, guess what? --

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Sasha Gusev

@SashaGusevPosts

1 year

A 🧵 on algorithms for predicting regulatory variant effects to help understand complex disease. IMO an extremely challenging problem that's at a glass mostly full / glass mostly empty point right now depending on who you ask.

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Sasha Gusev

@SashaGusevPosts

4 months

@paulspivak_ @MattyDubs7 @whstancil Brain volume is a measure of maternal health. Genetic scores for IQ have zero correlation with brain volume in siblings. *sad trombone*

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Sasha Gusev

@SashaGusevPosts

4 months

@Steve_Sailer @Tommy8788 @whstancil It's telling that you've dropped the kindly gentleman racist bit completely now -- "angry midwits" -- and stopped responding to data long ago. It doesn't take much for your little project to collapse.

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Sasha Gusev

@SashaGusevPosts

1 year

this part hit a little too close to home

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Sasha Gusev

@SashaGusevPosts

1 month

More recently, genetic analyses have shown that even the weaker predictions about stratification have either not materialized or even reversed []. Theory should be judged by the accuracy of its predictions, and The Bell Curve fared poorly. /x

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Sasha Gusev

@SashaGusevPosts

4 months

@Steve_Sailer I've addressed your blather in detail here. Now perhaps you can indulge me in addressing some questions you dodged from previous discussions.

Sasha Gusev

@SashaGusevPosts

4 months

So this is pretty typical of the low-information content you get from the genetic racists. The majority of this post is just blather but there is one (1) specific claim about genetics: that the molecular genetic contribution to IQ keeps going up every year. This is false. A 🧵:

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Sasha Gusev

@SashaGusevPosts

4 months

@Steve_Sailer 2: Can you address the fact that recent studies show IQ was incorrectly modeled in The Bell Curve and is a worse predictor of job performance than basic interviews?

Sasha Gusev

@SashaGusevPosts

8 months

@Steve_Sailer @Tyler_A_Harper Steve you should actually read something from the past decade instead of relying on a patchwork of anecdotes and conspiracy theories:

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Sasha Gusev

@SashaGusevPosts

5 months

I've written about the genetics of educational attainment [ ] as part of a broader doc on heritability. I'll summarize the key points here, critiques very welcome! Also some pointed thoughts at the end on the state and future of this research. 🧵

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Sasha Gusev

@SashaGusevPosts

1 month

This is the sociological acid trip that shaped the public view of intelligence and society in the 90's. Of course, none of these cultural trends materialized, with crime and unemployment falling to record lows and education to record highs.

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Sasha Gusev

@SashaGusevPosts

4 months

The American Society of Human Genetics has written a detailed report on the history of eugenics and racism. Including a number of statements denouncing misguided beliefs about intellectual inferiority and racial supremacy.

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Sasha Gusev

@SashaGusevPosts

4 months

Finally, on the shoddy online survey of "intelligence" researchers going around. This thread highlights the methodological flaws and re-iterates the important point: scientific theories "acquire credibility due to consensus of high-quality evidence". /x

Vinay Tummarakota

@unboxpolitics

4 months

Wanted to emphasize that scientific theories do *not* acquire credibility due to consensus of "expert opinion". They acquire credibility due to consensus of high-quality *evidence*.

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Sasha Gusev

@SashaGusevPosts

2 months

"provide misleading results" IQ tests have an inherent problem of construct validity -- no one can agree what they actually measure. Vastly different models are not identifiable from typical data and causal theories are often ignored entirely.

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Sasha Gusev

@SashaGusevPosts

2 months

In short: maybe the children are not wrong and the field of intelligence research could benefit from a bit more ... introspection. /x

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Sasha Gusev

@SashaGusevPosts

4 months

This was echoed by four leading evolutionary/population geneticists in another detailed explainer. Their conclusion: "genetics has only served to undermine its own racist history."

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Sasha Gusev

@SashaGusevPosts

3 months

We should care about causes, and race is a poor causal model of human evolution. In truth, genetic variation follows a "nested subsets" model, where all people eventually share ancestors, which is fundamentally different from race (see for yourself here: ).

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Sasha Gusev

@SashaGusevPosts

1 year

This thread on human disease architecture generated a lot of interesting discussion and I wanted to highlight some important concepts that we still DON'T know the answer to (mostly suggested by others):

Sasha Gusev

@SashaGusevPosts

1 year

A 🧵 on some of my intuitions/priors about the genetics of complex and molecular traits in humans (i.e. what I think of as typical), largely motivated by GWAS/QTL studies over the past decade [citing papers with nice figures where possible]

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Sasha Gusev

@SashaGusevPosts

5 months

-- structured interviews are indeed much more accurate at predicting employee performance with lower racial bias! Unstructured interviews are really bad (as are other seemingly 'objective' metrics like years of experience). "DEI" here was just fair & effective hiring.

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Sasha Gusev

@SashaGusevPosts

4 months

@Steve_Sailer 3: Can you address the related finding that diverse hiring without an IQ test can produce equally good job performance? Following your advice makes business less effective!

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Sasha Gusev

@SashaGusevPosts

1 year

Another snapshot of soft-money lab funding: the path to being able to fully cover my salary (green rows were funded).

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Sasha Gusev

@SashaGusevPosts

4 months

@NAChristakis Or if this is a serious conversation, perhaps you and the Enron billionaire can inform us how you would restructure Harvard's Math 55 so it's not so grade inflated?

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Sasha Gusev

@SashaGusevPosts

7 months

"genetics and psychometrics" twitter:

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Sasha Gusev

@SashaGusevPosts

4 months

@kareem_carr Yes, it's a huge problem. *Any* mechanism will get counted as heritability, and that will include stuff like discrimination via pigment or staying out of school for an autoimmune disease.

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Sasha Gusev

@SashaGusevPosts

9 months

A few years ago I requested access to GWAS summary statistics from a variety of published studies that stated "Data Available Upon Request" and tracked the process: 4 studies, ~40 emails, 2 provided the data, taking an average of 22 weeks. Not great!

Dr Emma Anderson

@emmylooroll

9 months

The response I received when very kindly asking a Cambridge Prof if they would share their GWAS sumstats, also said I’d include them as coauthors on any resulting papers… I.e. no, go and run the whole GWAS again yourself. THIS IS BAD SCIENCE. Also, not even a Dear Emma? Rude.

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Sasha Gusev

@SashaGusevPosts

9 months

This was an interesting read from Plomin and Deary on the genetics of intelligence. Notably, they make five predictions about what we should expect to see from molecular data, based on their decades of experience with twin studies. Do they hold up? A 🧵:

Genetics and intelligence differences: five special findings

Molecular Psychiatry - Genetics and intelligence differences: five special findings

www.nature.com

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Sasha Gusev

@SashaGusevPosts

2 months

I highly recommend anyone working with single-cell data read this and take these issues seriously. These tools are under active development, which is terrific and to be applauded, but has also created a very fractured methods ecosystem. 1/

Lior Pachter

@lpachter

2 months

The choice of whether to use Seurat or Scanpy for single-cell RNA-seq analysis typically comes down to a preference of R vs. Python. But do they produce the same results? In w/ @Josephmrich et al. we take a close look. The results are 👀 1/🧵

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Sasha Gusev

@SashaGusevPosts

1 year

A 🧵 on study sections and grant review, the mechanism by which federal grants are evaluated and how many of us support our labs. A lot of opinions here so please yell at me where you disagree.

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Sasha Gusev

@SashaGusevPosts

1 year

A thread of some interesting genetics papers from 2022 [figures are theirs, comments/summaries are mine]

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Sasha Gusev

@SashaGusevPosts

1 month

Anyone else struggling with conjunctive verbs in their writing: repeatedly starting sentences with "However,"/"Moreover,"/"Likewise,"/"Consequently," etc. And is there a good way to break this?

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Sasha Gusev

@SashaGusevPosts

4 months

Fin

dialecticbio.bsky.social

@DialecticBio

4 months

Race science can't stop losing

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Sasha Gusev

@SashaGusevPosts

4 months

@patientsnail The entire field looks at this stuff with a mixture of disgust and embarrassment. People are using methods we develop in absolutely idiotic ways, drawing obviously wrong conclusions, never subjecting them to peer-review, and instead passing them around like it's Secret Knowledge.

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Sasha Gusev

@SashaGusevPosts

4 months

Their statements on erroneous claims of groups with "good genes" [] and racial supremacy [] are specifically worth reading.

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Sasha Gusev

@SashaGusevPosts

5 months

I write about why and how should we talk about behavioral heritability []. A partial response to the Hastings Report [], which I found to be important but also fundamentally flawed in it's proposed solutions. Key points 🧵:

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Sasha Gusev

@SashaGusevPosts

2 months

The author also seems to think the Ravin's [sic] are a silver bullet against the claim of cultural bias, a view that's heavily disputed in the field itself. The cultural specificity of filling in left-to-right matrices should be obvious to anyone who has ever read a comic book.

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Sasha Gusev

@SashaGusevPosts

10 months

@charlesmurray Let's get you to bed grandpa. Genetics explains <20% of educational outcomes and the majority of that is via parental environment. Individuals with equivalent genetic scores for education have much higher math achievement in high-SES schools.

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Sasha Gusev

@SashaGusevPosts

1 month

Seems pretty simple: 1. Universities really like tests 2. The pandemic made testing more difficult and also hurt enrollment 3. The pandemic is over 4. Universities will always describe any policy change as improving equity

Derek Thompson

@DKThomp

1 month

What’s the best explanation for why all these schools turned against the SAT around the same time and why they all re-embraced standardized testing at roughly the same time? (Besides herding behavior)

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Sasha Gusev

@SashaGusevPosts

4 months

@paulspivak_ @DeepAlphaeus @MattyDubs7 @whstancil What even is this? Some anon generated a chart in, I guess, a completely different data set with no description of the method or even the effect scale? This isn't even grasping at straws, it's some new worse thing.

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Sasha Gusev

@SashaGusevPosts

3 months

Let's see what's those ellipses are hiding ...

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