Nature - A surface-centric approach captures the physical and chemical determinants of molecular recognition, enabling the de novo design of protein interactions and of artificial proteins with...

The development of RNA exporters, based on capsids and nanocages, for packaging and secretion of RNA, non-destructive monitoring of cells, and cell-to-cell delivery of mRNA.

Nature - A study details the creation of an Escherichia coli genetically recoded organism that is resistant to viral infection, and describes a further modification that keeps the organism and its...

Nature Biotechnology - Cell-specific molecular delivery with enveloped delivery vehicles enables genome editing ex vivo and in vivo.

Nature Biotechnology - A microfluidics-free, scalable single-cell RNA-sequencing method produces high-quality transcriptomes.

Integrating synthetic coevolution and machine learning enables prediction of remodeled protein-protein interfaces.

Nature - The tail fibre of an extracellular contractile injection system (eCIS) from Photorhabdus asymbiotica recognizes targets expressed on eukaryotic host cells, and can be reprogrammed to...

Nature Methods - A Ni2+-modified MspA nanopore construct can unambiguously discriminate the 20 proteogenic amino acids as well as several post-translational modifications.

Engineered probiotics produce synthetic targets to facilitate immunotherapy of solid tumors by CAR T cells.

A key challenge of the modern genomics era is developing data-driven representations of gene function. Here, we present the first unbiased morphology-based genome-wide perturbation atlas in human...

A system to express tumor antigens in the skin commensal bacterium Staphylococcus epidermidis elicits T cells that treat local and systemic tumors.

Nature - The authors introduce a single-molecule DNA-barcoding method, resolution enhancement by sequential imaging, that improves the resolution of fluorescence microscopy down to the...

Nature - A mechanism of lipid transport inhibition has been identified for a class of peptide antibiotics effective against resistant Acinetobacter strains, which may have applications in the...

Nature Aging - The accumulation of senescent cells drives age-related diseases. In this study, the authors show that senolytic CAR T cells can rejuvenate metabolic function and fitness in old mice...

Nature - Blood plasma protein data was combined with machine learning models for a simple method to determine differences in organ-specific aging; the study provides a basis for the prediction of...

The genome is a sequence that completely encodes the DNA, RNA, and proteins that orchestrate the function of a whole organism. Advances in machine learning combined with massive datasets of whole...

Cells self-organize molecules in space and time to generate complex behaviors, but we lack synthetic strategies for engineering spatiotemporal signaling. We present a programmable reaction-diffusion...

Nature - Using kidneys from a genetically engineered porcine donor transplanted into a cynomolgus monkey model, the design, creation and long-term function of kidney grafts supporting life are...

An engineered probiotic system locally delivers checkpoint blockade nanobodies to tumors for sustained therapeutic release.

Intravenous priming agents given 1 to 2 hours before a blood draw increase circulating tumor DNA recovery by 19- to 60-fold.

Nature Biotechnology - Compressed Perturb-seq incorporates compressed sensing to genetic screening for scalable discovery of genetic interactions.

Nature Biotechnology - Protein expression from circular RNAs is enhanced several hundred-fold by optimizing vector design.

Bacterial GII-C intron ribozymes are programmable and self-guided endonucleases active for sequence-specific DNA manipulation.

A technical primer on CRISPR-based gene drives, which hold massive potential for mitigating the harms invoked by some species. We cover what a gene drive is,...

Nature Biotechnology - An engineered skin microbe produces a therapeutic molecule that reduces sebum in mice.