hosting a small gathering to watch In Silico, the documentary about the 10-year, $1B failed quest to simulate a brain! ego, conflict, scientific feasibility all come into question.
this sunday, 8PM, SF
dm for invite :)
thinking about the fact that most of my friends who drop out to become operators still want to continue learning math/physics, but it becomes exponentially harder to justify doing so in comparison to faster feedback loops in their other work.
1/3
in 2007, DARPA put out 23 mathematical challenges which are about as undefined as they can get including finding a "mathematical theory of the brain" and the "fundamental laws of biology" (the 100 year question)
so many biology problems!
(h/t
@_julesh_
)
working on longevity research is possibly a good cure for people who are indecisive about what to work on in their lives and don't feel strongly about something:
if you live forever…you *could* work on anything and everything
The new trailer for the Oppenheimer movie directed by Christopher Nolan came out and it's incredible, but I implore people to watch this documentary before they go see it in theaters
Isaac Asimov on New Ideas — curious for comments on “to be creative in public is particularly bad”, which is against the wave of building in public, building with the garage door up, etc.
My second tweet ever was about
@joininteract
, and it’s been an annual tradition since then! It is still beautiful to me how many talented, ambitious, and humble individuals I’ve met through Interact. ❤️
Currently on a delayed flight to SFO, pilot says:
“Turns out our 15 minute delay is actually 15 airline minutes — an airline minute is a quantum phenomenon because no one knows how long they actually are”
A big deal.
This positions the GLP-1 drugs not just as weight loss medicines, but as treatments that prevent heart disease. We will need to see the full data and read outs from other trials, but this changes the discussion.
Learning "by the numbers" is something many of my friends have gravitated towards. Sometimes I wonder how useful it really is, but it does allow for quick sanity checks if done well, and is very fun!
Compiling a small list (please send your favorites!):
If anyone would like to work through Feynman's Lectures on Physics w/ me, please DM! Focus would be on understanding and re-explaining concepts weekly, and working through the problem sets. <3 no previous physics experience necessary
“Learning how to think" really means learning how to exercise some control over how and what you think. It means being conscious and aware enough to choose what you pay attention to and to choose how you construct meaning from experience.
- David Foster Wallace
hi folks! has anyone received an RFE for an O1 before and dealt with it successfully / have any advice or ways to help?
Thanks :) can’t believe how stressful these processes are in the US
Reading a paper about the brain in numbers and still can’t believe that until ten years ago, we thought glial cells outnumbered neurons 10:1 (actual value is 1:1!)
So much of science is updating “common knowledge” from novel or more accurate tooling / methods
My yearly Interact tweet — two years in, still one of the best communities I've ever been a part of. So many stories of meeting incredible, value-aligned people only to realize that they are/were an Interact Fellow.
If you have any questions, feel free to reach out! :)
There are only two weeks left to apply to the Interact Fellowship. If you are 18-23 years old and care deeply about the transformative role of technology, apply now!
individual taste comes from excessive consumption
1/ mathematical intuition requires doing lots of math
2/ personal style comes from trying on a lot of clothes
3/ writer's voice comes from writing all the time
no guarantees on a "good" taste but then it comes down to refinement
The team at Renaissance has been an unstoppable force for scientific progress. They know how to move the needle efficiently on thorny projects.
Excited to follow
@tkalil2050
@KumarAGarg
’s progress!
I am excited to announce the launch of Renaissance Philanthropy, with a phenomenal team including
@KumarAGarg
. Our goal is to help foundations and philanthropists promote a 21st century renaissance, fueled by advances in science, technology and innovation.
they typically hire a tutor, some even start groups to get through textbooks together which usually tapers off over a couple months. there's often some bad feeling that is built up after this. I wonder if it's because of the lack of some external factor.
2/3
life is that short period of time
between two eternities -
when matter, through the mixing of chemicals
is electrically induced to unite
and become willfully active.
until the electricity stops.
hence - life is matter gone willful, for a while
- Neil Jenney
I wish there was a twitter mechanism that was just book (or textbook, essay, articles, letter, blog, inspirations, etc.) recommendations from your favourite accounts
does anyone know inspiring biotech companies, VCs, or spaces in NY to visit or would be down to give a presentation to a group of Princeton students in early May?
I have a really excellent crew of students who are motivated, brilliant, and the future of bio :)
Into c.elegans and big data approaches? We (with
@eboyden3
and many others) started shopping around a proposal to basically identify all the I/O functions of all the neurons and produce massive complementary data. Any feedback appreciated.
@elidourado
and I have spent the last few weeks working on this piece. It's time to try something new and diversify what it means to work on Alzheimer's research.
New short paper with
@JoanneZPeng
:
It turns out the government has plenty of budget for aging research. It’s all just misguidedly earmarked for Alzheimer’s disease.
This is something that can be fixed by persuading four committee staffers.
Tiny Machines teasers:
@joannezpeng
made this trailer. Now one of my favorite science-inspirational things to watch.
I made this crazy cartoon about how I think
The biggest science prize in history has been launched with a $101M purse. 🧬
The goal? To improve human aging by at least 10 years, with a focus on cognitive, immune, and muscle function.
This is huge.
Read my take on what it means for humanity with quotes by
@elonmusk
,…
Congratulations on the launch
@SGRodriques
and Future House team! Excited to see what comes from the 10-year vision, and heads-up, they're hiring interns :)
Today, we are announcing Future House, a philanthropically-funded moonshot focused on building an AI Scientist.
At Future House, our 10-year mission is to build semi-autonomous AIs for scientific research, to accelerate the pace of discovery and to provide world-wide access to…
I'm always amazed at the beautifully designed diagrams to explain complex concepts from academic papers — ex:
@nature
news and views section…
what if every paper published had this as a norm? do great labs have great design people on their team as well?
dream incubation prior to taking a short nap, like thinking about the word "tree" to dream about trees, is related to better creative insights on theme-related tasks afterwards🌲
this stuff is wild, we know so little about sleep!
finally watched verdens verste menneske (the worst person in the world) at
@WendiYan5
's recommendation, and it's one of the most exquisite, heartbreaking, real, romantic films I've ever seen -- easily tops before sunrise for me.
it's also cinematographically stunning:
"I seem to have been only like a boy playing on the seashore, and diverting myself now and then in finding a smoother pebble or prettier shell than ordinary, while the great ocean of truth lay all undiscovered before me."
- Isaac Newton
today I learned you can just *lose* memory for hours with no underlying conditions or other symptoms and nobody agrees why it happens? (transient global amnesia)
what fresh hell is this
I’m proud to announce the Time Initiative-accelerating talent in
#aging
biology. A future where we live healthier, longer will be shaped by next-gen innovators. My mission is to activate undergrad students’ interest in aging and accelerate their growth into leaders of the field.
Alumni of
@Princeton
in Boston, we’re hosting an event at
@pillar_vc
tonight from 6-8! Princeton biotech group is in town — DM for details and I’ll get you on the list :)
Why care about human longevity? 🧵
Aren’t programmable drugs for future pandemics more pressing? What about childhood cancers—or preventing existential risks to extend our longevity as a species? Aren’t humans a burden on the planet? Doesn’t science advance one funeral at a…
Feeling all sorts of feelings introducing Kernel to the world! Kernel has truly been a collective labour of love, and I'm honoured to steward this work alongside so many other wonderful people. A thread on what magazine is about & how it came to be🌿
A wonderful opportunity for young, ambitious undergraduates in all fields to get hands-on experience in aging biology. Wish I had this when I started out in the field :)
Comes with a network of peers, mentorship, and the opportunity for funding
Create a healthier future for all of us. 🌍 Apply for the Time Initiative Fellowship and join the next wave of leaders in
#AgingBiology
. Deadline: June 30th. Watch and share with the ambitious
#undergrads
you know!
#TimeInitiative
🎥 full video:
We’re excited to open the applications for the Brains Coordinated Research Accelerator!
This part-time program’s goal is to help people with ambitious research ideas refine them and find a place to execute on them in government organizations, nonprofits, and beyond.
1/
I have no idea if this will work, but tomorrow at 6pm PT will try showing what it's like to do a visual thought experiment in biology.
This might completely fail, but it's really joyful if you get it right. Just messing around, nothing vetted to work.
@michael_nielsen
you can play around with this personally for more intuition:
1) download predicted pdb from alphafold
2) open in pymol or UCSF chimeras
3) you can visualize from the beta sheet/alpha helices view to the individual amino acids as well as surface area accessibility
moving out of my current place tomorrow but somehow a ridiculous amount of books found me yesterday night; if anyone in cambridge wants books to add to their library, lmk :)
I had the good fortune of spending a few months in Los Alamos with some friends in 2020, and watched it before going to New Mexico. I've never felt the historical significance of a place more than when we drove up the canyon into the town.
everyone in biotech reads genentech: the beginnings of biology, but I think invisible frontiers: the race to synthesize a human gene is underrated
there's a lot of political and scientific context that is missed in the former!
lifestyle wars at the guggenheim in 2017 by anicka yi
"natural and technological forces appear as surging, unruly forms that are nonetheless clinically contained"
This is so beautiful! I've been spending some time playing around with
@leanprover
(proof assistant) through this game, recommended by
@SebastienZany
.
@rSanti97
the institute for replication!!! how do we convince them to do science papers / put grants up for grad students to independently replicate in their own free time?
here's one of my favorite explanations of why spaced repetition works (with built-in flashcards) by
@ncasenmare
called "how to remember anything forever-ish"
So my trick for reading and grokking all the foundational textbooks intently is...
Anki flash cards
...ie spaced repetition. Works really well for knowledge you know you will need in the future
Extraordinarily excited to work with this group of talented individuals. If you're interested in putting into words much of the conversation on longevity research, please get in touch! ✨
Working in partnership w/
@calebwatney
&
@alecstapp
, we are thrilled to announce our new Progress Studies Policy Accelerator cohort! These fellows will spend the next 6 weeks crafting policy proposals to advance progress in science, tech, & innovation.
@0interestrates
it's still going to take >10 years to see what the current cohort does though, wouldn't count them out...in my year 2019 there were a few scientists / researchers too, would love to see more of them being funded
Recently, I've been drawing a lot of inspiration from Newton's notes at age 22, where he wrote an incredible list of questions and thought experiments in all different fields.
Are there any notebooks / writings that would provide similar inspiration?