Last night, no one at
@MIT
had a good night’s sleep.
Yesterday evening, shortly after I posted that we were launching a plagiarism review of all current MIT faculty, President Kornbluth, members of MIT’s administration, and its board, I am sure that an audible collective gasp
Eleven years ago I started writing about how HPV causes head and neck cancer. Lots of it. Thousands of cases every year. Two of the patients I wrote about during this time died.
Tonight the FDA approved Gardasil to prevent head and neck cancer.
The Pfizer/BioNTech Covid-19 vaccine showed 90% efficacy.
For biotech folks: Interim was done at 94 cases, not 32.
There are questions.
But this is hope.
A big one.
I've been saying for a decade: "This is biology's century." And we're still not ready.
My editors asked me to explain what that means. It was harder than I expected. I hope you like reading it.
This morning, we're releasing a look at all the clinical trials against
#COVID19
. One big conclusion: we've spent a lot of resources on
#Hydroxychloroquine
, probably too much.
You see that Jupiter-sized orb towering above all those other planets?
“I mean seriously, in an age when we fly by Pluto and send Jimmy Carter’s metastatic melanoma into remission, how is it we cannot figure out how to hire and promote female professors of chemistry?”
@CarolynBertozzi
via
@lisamjarvis
This current discussion from the CDC on collecting data about the vaccines just reveals how terrible the U.S. collection of health data are. All of it goes back to our fragmented IT infrastructure. Compare it to the data coming from the U.K.'s NHS.
The pandemic wouldn't have been as bad if public health officials had realized most people regard in-person social interaction as 'essential', are not bad people for it, and that a strategy centered around expecting them to sacrifice it for months at a time was never gonna work.
Some news.
@adamfeuerstein
,
@damiangarde
and I have been awarded the George Polk Award for Medical Reporting for our coverage of the story behind the FDA approval of the Alzheimer's drug Aduhelm. 1/4
3. The magnitude of benefit has been consistent over time, for different Omicron subvariants. Here in May, across all ages, H/T
@redouad
, 96% reduction of death for 4 shots vs unvaccinated
Today I'm watching the FDA advisory committee panel regarding expanding the authorization for the Moderna vaccine to children aged 6 years through 17 years.
I'm going to keep my observations in this thread.
“The handling of the COVID-19 pandemic in the United States will go down as the worst public health disaster in the history of the country,”
@EricTopol
writes.
Blistering piece. Says US betrayed its health care workers.
This news is a cautionary tale for anyone believing that Alphabet, Amazon, Apple, or (A)nyone is going to come from tech and make easy progress in healthcare. This stuff is hard.
Alphabet's Verily and Novartis eye-care subsidiary Alcon are pulling the plug on the glucose monitoring "smart lens" device the two companies had been attempting to build since 2014 by
@mtindera07
This is a big deal.
An oral Covid drug could really change the pandemic.
One pair of numbers keeps sticking in my head: 8 vs. 0. Those are the number of deaths in the placebo and drug groups.
$MRK
Scott Atlas deletes Twitter account.
"In my view, Twitter has become a destructive place that mainly inflames extreme thinking and disseminates distortions, rather than elucidating factual information and respectful, civilized discussion. "
There's a reason
@SueDHellmann
is a biotech legend: her calm, data-based approach to everything.
I called her for a quote on coronavirus. We decided to print almost the entire conversation.
#COVID19
For those who need to hear it: the fact that VAERS data are misused or misunderstood by frequently does not meant that VAERS is not important. Yes, it contains erroneous reports, but it was designed as an early warning system.
A big deal.
This positions the GLP-1 drugs not just as weight loss medicines, but as treatments that prevent heart disease. We will need to see the full data and read outs from other trials, but this changes the discussion.
President
@realDonaldTrump
tweeted that the deep state is leading the FDA to slow studies of treatments and vaccines for Covid-19.
The evidence we have points to the FDA, in fact, speeding up these efforts considerably.
"60 Minutes" producer Katy Textor dies. Produced Theranos whistleblower spot, as well as story on murder charges against doctor accused of administering lethal injections during Katrina.
I've wanted to write about Kathrin Jansen, who heads Pfizer's vaccine R&D efforts, including Covid-19, for years.
In the words of
@DrPaulOffit
: "People who think pharmaceutical companies are evil should spend time with people like Kathrin Jansen.”
I'd like to share a little story about Jimmy Carter, starting with a reporter's keepsake.
These are the notes President Carter handed me after I met him at a $MRK event to celebrate the company's collaboration with the Carter Center to end river blindness. A thread. 1/7
A
#Parkinsons
‘game changer,’ backed by Michael J. Fox, could lead to new diagnostics and, someday, treatments
I don't usually do the ICYMI thing, but this was fun to do and I wanted an excuse to post this pic of
@realmikefox
and me again.
There aren't a lot of heroes who stay heroes when examined closely. I think Jimmy Carter is one who gets more heroic the harder you look.
I don't save much, but I saved that piece of hotel stationary.
8/8
It could be the vaccine of choice for the world.
A look at the data just released in NEJM and the excitement and debate about the $JNJ's experimental Covid vaccine.
South Africa halts rollout of AstraZeneca’s Covid-19 vaccine after shot falters against variant
My story on today's mess. So many caveats on the data but I'm afraid there is no way this is good news.
My friend
@NoraSee
is an artist in New Orleans. She competed in a
#D23
costume contest related to the haunted mansion.
Check this out: it's based on the bat stanchion's in the mansion, and it is, IMO, some Jim-Henson-level dress up.
Douglas Melton, the famed stem cell researcher, is leaving Harvard to work at the drug company full time.
“Given my personal interest in type 1 diabetes, I’m convinced that I could be most effective at the company that’s leading the area," he told me.
U.S. cancer death rate drops by largest annual margin ever, report says.
The drop in deaths seems to have been accelerated by recent lung cancer treatment advances.
MHRA regulators showed this slide on the balance of risks from rare clots caused by the $AZN vaccine and the risk from Covid-19. It's helpful when thinking about these issues -- and makes it clear why UK is changing course of people aged 20-29.
I have the flu. I got the shot. The immunization may have decreased severity of the infection -- my fever's not that bad. But my head hurts a lot and I'm so, so tired.
Which is to say: Get your flu shots.
Hal Barron leaving $GSK to run Altos, a company focused on reversing disease by reprogramming cells, with Rick Klausner and Hans Bishop.
They say they've raised $3 billion.
Fox anchor: Can you tell me your thoughts on the drug that is used normally to treat malaria.
Dr. Haseltine: It's sad to me that people are promoting that drug.
Anchor: But what about the anecdotal evidence?
Haseltine: That's complete and utter nonsense. Irresponsible.
Seriously, this is one of the most fun entrepreneur stories I've done in 18 years at Forbes. Come for fun narrative, stay for the discussion of medical privacy and data quality.
#ForbesUnder30
How was my holiday break? Well, a bit panicked. Both my kids, who are adolescents, developed Covid.
Both are fine. My daughter had a fever for two days; my son has seemed asymptomatic. 1/10
Will $JNJ continue with the vaccine platform it used for Covid? No.
“We decided not to continue to advance the platform because of these very rare but serious events that occurred with the Covid vaccine....
You probably need some fun. Well,
@rtnarch
is starting a company, raising $800 million. Yes, $800 million.
The goal? Transform biotech manufacturing. The name? Resilience.
“We want to own the next generation of manufacturing technology." 1/5
Harvard scientist
@skathire
thinks he has a genetic test for heart attack risk. Even more surprising: He wants to give it away for free.
Also featuring
@hmkyale
.
@Niners_Gaye
@HelenBranswell
(1) because the 95% is not available at that moment (2) because you want a one dose vaccine (3) because the more people who are vaccinated now, the fewer strains we'll have to deal with.
Sony Pictures Entertainment CEO Tony Vinciquerra says that “very famous people whose names I won��t use” want to redo Norman Lear’s ‘The Princess Bride’
Pfizer and BioNTech:
**FULL results
**95% efficacy
**Submitting EUA
**Efficacy against severe disease
**Side effects include fatigue, headache
By me and
@damiangarde
At 24, Nat Turner started a company to change the way we study cancer. Now he and Flatiron Health co-founder Zach Weinberg are worth at least $250 million each, and Nat is on the cover of Forbes.
#ForbesUnder30
Story by me and
@ellie_kincaid
.