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Stirling Churchman Profile
Stirling Churchman

@fiddle

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@HMSgenetics professor. Interested in RNA dynamics across the cell esp. nuclear transcription and splicing and mitochondrial gene expression. (she/her)

Cambridge, MA
https://t.co/ccQSf8MOKT
Joined November 2007
Don't wanna be here? Send us removal request.
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@fiddle
Stirling Churchman
@fiddle
2 months
I'm thrilled to see the cover of @NatureSMB this month! My sibling Leidy Churchman made this special painting to illustrate our latest work on the packaging of mitochondrial DNA. Both works are nicely described in the "Musings on art and science" editorial
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@fiddle
Stirling Churchman
@fiddle
4 years
What did you guys do yesterday? I got married on zoom! @andystrominger
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Stirling Churchman
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6 years
It’s official, the best lab website is the Heiman lab website! It’s a must see, but make sure you have some time to kill.
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@fiddle
Stirling Churchman
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2 years
How does RNA flow through the cell? From their synthesis, chromatin release, nuclear export, ribosome engagement, and eventual degradation, we quantified the lives of human transcripts genome-wide. (1/7) See @BrendanSmalec and @robertietswaart ‘s preprint
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Genome-wide quantification of RNA flow across subcellular compartments reveals determinants of the...

Dissecting the myriad regulatory mechanisms controlling eukaryotic transcripts from production to degradation requires quantitative measurements of mRNA flow across the cell. We developed subcellular...

www.biorxiv.org
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@fiddle
Stirling Churchman
@fiddle
2 years
Splicing of human introns could occur in any order across an RNA, which combinatorially adds up to thousands of possible splicing orders for a typical transcript. Are all orders used? Read our latest preprint by @Karine_Choquet to find out! (1/6)
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Pre-mRNA splicing order is predetermined and maintains splicing fidelity across multi-intronic...

Combinatorially, intron excision within a given nascent transcript could proceed down any of thousands of paths, each of which would expose different dynamic landscapes of cis-elements and contribute...

www.biorxiv.org
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@fiddle
Stirling Churchman
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5 years
Ever had a list of gene hits and not known what to do? Maybe GO enrichment left you wondering what your favorite gene is doing in your experiment? Check out GeneWalk, our #ML method that determines the relevant functions for each gene @robertietswaart (1/4)
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GeneWalk identifies relevant gene functions for a biological context using network representation...

The primary bottleneck in high-throughput genomics experiments is identifying the most important genes and their relevant functions from a list of gene hits. Existing methods such as Gene Ontology...

www.biorxiv.org
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Stirling Churchman
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3 years
GeneWalk is now published! Ever had a list of gene hits and not known what to do? Maybe GO enrichment left you wondering what your favorite gene is doing in your experiment? GeneWalk determines the relevant functions for every gene hit! @robertietswaart
@GenomeBiology
Genome Biology
@GenomeBiology
3 years
GeneWalk, from @robertietswaart , @fiddle and co, is a method for prioritizing genes from a gene list. Given a list of genes, eg from RNA-seq experiment, it constructs a regulatory network and uses GO annotations to identify the most relevant genes.
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@fiddle
Stirling Churchman
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2 years
How are the hundreds of copies of mitochondrial DNA packaged in our cells? It’s a mystery because histones and chromatin factors are not in mitochondria and the high copy number presents challenges! Read what Stefan @rsisaac found in our preprint. (1/7)
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Single-nucleoid architecture reveals heterogeneous packaging of mitochondrial DNA

Cellular metabolism relies on the regulation and maintenance of mitochondrial DNA (mtDNA). Hundreds to thousands of copies of mtDNA exist in each cell, yet because mitochondria lack histones or other...

www.biorxiv.org
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Stirling Churchman
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3 years
Our protocol for direct sequencing of nascent RNA is now published! Nanopore analysis of CO-transcriptional Processing (nano-COP) took us four years to get right. In this protocol, we describe the final approach *and* how we got there. (1/3)
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5 years
Human genes have so many introns! When and how are they all spliced out? Does splicing follow the order of transcription? Are neighboring introns spliced cooperatively? These fundamental questions are crucial to our understanding of splicing regulation. (1/4)
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3 years
Human respiratory complexes are encoded on both nuclear and mitochondrial DNA. Is gene expression coordinated across these genomes that are expressed in separate compartments and by different factors? Read our latest preprint to find out! (1/7)
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Balanced mitochondrial and cytosolic translatomes underlie the biogenesis of human respiratory...

Oxidative phosphorylation (OXPHOS) complexes consist of nuclear and mitochondrial DNA-encoded subunits. Their biogenesis requires cross-compartment gene regulation to mitigate the accumulation of...

www.biorxiv.org
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Stirling Churchman
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1 year
How are nuclear and mitochondrial DNA co-regulated to achieve balanced oxidative phosphorylation (OXPHOS) subunits? We performed a CRISPR screen to identify human genes that maintain mitonuclear balance. See our preprint by Nick Kramer and @GyPrak (1/4)
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Genome-wide screens for mitonuclear co-regulators uncover links between compartmentalized metabol...

Mitochondrial oxidative phosphorylation (OXPHOS) complexes are assembled from proteins encoded by both nuclear and mitochondrial DNA. These dual-origin enzymes pose a complex gene regulatory challe...

www.biorxiv.org
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Stirling Churchman
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4 months
How does Pol II navigate the crowded, complex chromatin environment, surrounded by nucleosomes and other transcriptional activity? We are excited to share our preprint, a fantastic collaboration with @stergachislab , led by Tommy Tullius @mtcicero26 (1/5)
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RNA polymerases reshape chromatin and coordinate transcription on individual fibers

During eukaryotic transcription, RNA polymerases must initiate and pause within a crowded, complex environment, surrounded by nucleosomes and other transcriptional activity. This environment creates...

www.biorxiv.org
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Stirling Churchman
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1 year
Another new preprint! “Regulatory principles of human mitochondrial gene expression revealed by kinetic analysis of the RNA life cycle.” Let us walk through a day in the life of a mitochondrial RNA. @ErikMcshane led this beautiful study. (1/n)
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Regulatory principles of human mitochondrial gene expression revealed by kinetic analysis of the...

Mitochondria play critical roles in cellular metabolism, primarily by serving as the site of assembly and function of the oxidative phosphorylation (OXPHOS) machinery. The OXPHOS proteins are encoded...

www.biorxiv.org
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Stirling Churchman
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7 months
🎉Our paper "Regulators of mitonuclear balance link mitochondrial metabolism to mtDNA expression" is now online! 🎉 Summary ⬇️but the published manuscript is greatly expanded! Congratulations to Nick Kramer, @GyPrak thanks to @KanarekNaama for collab.
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Regulators of mitonuclear balance link mitochondrial metabolism to mtDNA expression - Nature Cell...

Kramer, Prakash et al. share genome-wide CRISPR screens for factors that alter the levels of two dual-genome-encoded Complex IV subunits, COX1 and COX4. They identify PREPL and NME6 as genes that...

www.nature.com
@fiddle
Stirling Churchman
@fiddle
1 year
How are nuclear and mitochondrial DNA co-regulated to achieve balanced oxidative phosphorylation (OXPHOS) subunits? We performed a CRISPR screen to identify human genes that maintain mitonuclear balance. See our preprint by Nick Kramer and @GyPrak (1/4)
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@fiddle
Stirling Churchman
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3 months
🎉 🎉Our paper, "Single-nucleoid architecture reveals heterogeneous packaging of mitochondrial DNA," is now published! @NatureSMB See the tweets below ⬇️ for a summary. Congratulations to the whole team! @rsisaac @mtcicero26 @stergachislab 🎉🎉
@fiddle
Stirling Churchman
@fiddle
2 years
How are the hundreds of copies of mitochondrial DNA packaged in our cells? It’s a mystery because histones and chromatin factors are not in mitochondria and the high copy number presents challenges! Read what Stefan @rsisaac found in our preprint. (1/7)
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Stirling Churchman
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2 years
@OdedRechavi This is an original oil painting by my sibling, Leidy Churchman. I still can't believe @Nature passed on it. I love this painting so much. In the end, Leidy sold it to a collector at @ArtBasel . @MurrayGuyInc @MatthewMarks
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Stirling Churchman
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6 years
Ever wonder how mitochondrial and nuclear genes are coregulted to produce functional mitochondria? Here’s our review discussing what is known and all the work that needs to be done on: The Multiple Levels of Mitonuclear Coregulation
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Stirling Churchman
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3 years
My host spent a good hour telling me how eating meat is terrible for global warming, which I agree with but... I like bacon too much, I told him. At the dinner, everyone ordered vegan entrees clearly in deference to the host. I got the lamb chops, but not the job!
@StockMarketDrip
Stock Market Drip💧
@StockMarketDrip
3 years
What was your worst experience while on a job interview?
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Stirling Churchman
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6 years
Strong cell growth requires fast ribosome assembly, so proliferating cells dedicate nearly half their protein/RNA biomass production to new ribosomes. But at what cost? Our latest paper on bioRxiv addresses this question. 1/4
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Stirling Churchman
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3 years
Our latest preprint describes the high-resolution role of 41 factors in yeast transcription elongation using NET-seq. The 9-year multi-generation effort was lead by three first authors. Congratulations to @lachance_kate , @KharMT , and Mary Couvillion!
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Dynamics of transcription elongation are finely tuned by dozens of regulatory factors

Understanding the complex network and dynamics that regulate transcription elongation requires the quantitative analysis of RNA polymerase II (Pol II) activity in a wide variety of regulatory...

www.biorxiv.org
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Stirling Churchman
@fiddle
7 years
I joined twitter ten years ago today and here's my first tweet. It was the day I first dreamt up ideas for what would become NET-seq!
@fiddle
Stirling Churchman
@fiddle
17 years
Thinking about RNA polymerase
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9 months
🎉Our paper "RNA polymerase II pausing temporally coordinates cell cycle progression and erythroid differentiation" is now published in @Dev_Cell , a fantastic collaboration with @bloodgenes led by @Danyajane . See tweets ⬇️ for more! 🔴🔴🔴🔴🔴
@fiddle
Stirling Churchman
@fiddle
1 year
Does Pol II pausing control cell differentiation? @Danyajane , in collaboration with @bloodgenes , studied Pol II pausing and SPT5 in human erythropoiesis and found Pol II pausing temporally coordinates cell cycle progression and erythroid differentiation.
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Stirling Churchman
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4 years
We're looking for a PhD-level research scientist! Come help us elucidate how gene expression processes are coordinated, from the nucleus to the mitochondria. If you are considering a non-PI career path, but want to stay in academic research, please apply!
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Stirling Churchman
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2 months
🎉Our paper on the challenges and resolution of balancing nuclear and mitochondrial gene expression is out! @ErikMcshane 's deep dive into every step of mitochondrial gene expression is wild! 🎉 See tweets ⬇️ and the @MolecularCell article for much more.
@fiddle
Stirling Churchman
@fiddle
1 year
Another new preprint! “Regulatory principles of human mitochondrial gene expression revealed by kinetic analysis of the RNA life cycle.” Let us walk through a day in the life of a mitochondrial RNA. @ErikMcshane led this beautiful study. (1/n)
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Stirling Churchman
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2 years
Wonderful to see our work on human mito-nuclear balance published! We found that the synthesis of mitochondrial- and nuclear-encoded OXPHOS subunits are remarkably balanced in the 5 cell types we studied. Thanks @Antonio41949078 Barrientos lab for the collaboration.
@GenomeBiology
Genome Biology
@GenomeBiology
2 years
Soto, Couvillion, @fiddle & co study ribosome profiling data and uncover translational control to help equalize expression of mitochondrial and nuclear-encoded OXPHOS subunits. Imbalanced translatomes activate stress response.
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Stirling Churchman
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4 years
It's finally out! Lots of new data since the pre-print we posted last May.👮
@MolecularCell
Molecular Cell
@MolecularCell
4 years
Splicing Kinetics and Coordination Revealed by Direct Nascent RNA Sequencing through Nanopores
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Stirling Churchman
@fiddle
7 years
We are the wild type!
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7 years
Congrats to @Umut1Eser on our paper describing the ground state and evolution of promoter directionality!
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Stirling Churchman
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5 years
In this preprint we describe @nanopore analysis of CO-transcriptional Processing (nano-COP) that directly sequences nascent RNA. With human and Drosophila data, we answer the above questions and shed light on how splicing patterns are achieved (2/4)
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Human co-transcriptional splicing kinetics and coordination revealed by direct nascent RNA sequen...

Human genes have numerous exons that are differentially spliced within pre-mRNA. Understanding how multiple splicing events are coordinated across nascent transcripts requires quantitative analyses...

www.biorxiv.org
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Stirling Churchman
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4 years
If you’re wondering what the Churchman Lab has been up to lately, here it is, all at once.
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4 years
Our preprint on splicing dynamics in human cells is now published with 5x more data! Congratulations to Heather and Karine! All @nanopore data are here: and all analysis scripts are deposited:
GitHub - churchmanlab/nano-COP: Nanopore analysis of CO-transcriptional processing exposes the...

Nanopore analysis of CO-transcriptional processing exposes the nascent transcriptome via direct long-read RNA-seq - churchmanlab/nano-COP

github.com
@fiddle
Stirling Churchman
@fiddle
5 years
In this preprint we describe @nanopore analysis of CO-transcriptional Processing (nano-COP) that directly sequences nascent RNA. With human and Drosophila data, we answer the above questions and shed light on how splicing patterns are achieved (2/4)
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Stirling Churchman
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4 years
I’m angry, sad and sad. #BlackLivesMatter
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4 years
Congratulations to Andrew Stergachis and John Stam for developing such a powerful and straightforward approach to analyze chromatin fibers at the single molecule level! It was a blast to work with them on this.
@generegulation
Gene Regulation
@generegulation
4 years
Single-molecule regulatory architectures captured by chromatin fiber sequencing Fiber-seq: Single-molecule long-read sequencing of chromatin stencils enabled nucleotide-resolution readout of the primary architecture of multikilobase chromatin fibers
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3 years
@Caroline_Bartma In my graduate lab we had a “live” webcam video on our homepage. But it was actually a video loop of my bay mate pipetting sped up 1.5x. People would be like, I went to your website last night and saw David pipetting furiously at 10 PM!
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4 years
Educational graffiti on my walk yesterday. Promise I’m not the artist!
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3 years
2021 Churchman lab retreat! It was a local one this year with chalk talks in the garden. @HopeMerens got us started!
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8 months
@TriggerLoop I always appreciate seeing @IbrahimCisse_ definition slide.
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Stirling Churchman
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2 months
Watt Webb was my undergraduate mentor. And remains my role model. I walked into his office sophomore year and asked for a job, any job. I was a physics major with little to no understanding of biology. But I was curious. I started by sweeping the floors, literally (1/n)
@ryotaiino
Ryota IINO 飯野亮太
@ryotaiino
2 months
Biophysical Journal Call for Papers Special issue dedicated to Watt W. Webb: Point spread functions—from fluorescence correlation spectroscopy to multiphoton microscopy
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Stirling Churchman
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5 years
Our paper, "Proteotoxicity from aberrant ribosome biogenesis compromises cell fitness" is now online! Read the summary below, but the full paper has new MS data from @MartinWuhr ! Thanks also to Mike Springer, David Pincus and @NikkiCommins for the collab!
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Proteotoxicity from aberrant ribosome biogenesis compromises cell fitness

Rapidly proliferating cells are at risk of compromised cell fitness due to proteostasis collapse from perturbations that interfere with ribosome biogenesis.

elifesciences.org
@fiddle
Stirling Churchman
@fiddle
6 years
Strong cell growth requires fast ribosome assembly, so proliferating cells dedicate nearly half their protein/RNA biomass production to new ribosomes. But at what cost? Our latest paper on bioRxiv addresses this question. 1/4
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Stirling Churchman
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3 years
Join Mike Levine and me for a hybrid Keystone meeting on Gene Regulation! We have incredible speakers and will select many more from abstracts @mooreorless62 @IbrahimCisse_ @CramerLab @mayer_lab @AsifaAkhtar1 @DePaceLab @EKFarley @sandberglab @drosoigmm @tinekelenstra @youngricka
@KeystoneSymp
Keystone Symposia
@KeystoneSymp
3 years
Discover the latest in #GeneRegulation #transcription factors, #RNA & more with @fiddle @ChurchmanLab at the January @KeystoneSymp in Santa Fe. Scholarships applications are open to students, post docs & LMIC scientists, due Oct. 7.
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6 years
I'm excited to read this one as I've always wondered about the impact of GFP tags: Systematic assessment of GFP tag position on protein localization and growth fitness in yeast.
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4 years
A silver lining to @harvard classes being online is that I get to learn about black holes just hanging out in the living room. @andystrominger is in our kitchen teaching his ever popular "black holes and cookies" freshman seminar over zoom. Sadly this year, no cookies.
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3 years
Wonderful lab party this week on the Charles River! So fun to hang out again with everyone.
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3 years
Dark and uplifting at the same time. Beautiful quote. "The effort to understand the universe is one of the very few things which lifts human life a little above the level of farce and gives it some of the grace of tragedy." - Steve Weinberg, The First Three Minutes
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Stirling Churchman
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18 days
Wow, we’re on a role! Two covers in two months! For two fascinating stories on the fundamentals of mitochondrial gene expression!
@ErikMcshane
Erik McShane
@ErikMcshane
18 days
Very excited to see our work featured on the cover of the latest edition of Molecular Cell. Check out our manuscript to learn more about how the nuclear genome works together with the highly polyploid mitochondrial genome across the cell.
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4 years
@hopihoekstra We've started daily "standup meetings" on zoom. They get teams together quickly and frequently for <15 minutes. Everyone answers the following: 1) What did you accomplish yesterday? 2) What are your goals today? 3) Are there any barriers to your progress?
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Stirling Churchman
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3 years
I think I just felt an earthquake... Anyone else in Cambridge/Boston feel that?
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10 months
Happy to see @karine_choquet 's paper published! "Pre-mRNA splicing order is predetermined and maintains splicing fidelity across multi-intronic transcripts." See the preprint tweetorial or full results with expanded analysis: @NatureSMB @RouskinLab
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Pre-mRNA splicing order is predetermined and maintains splicing fidelity across multi-intronic...

Nature Structural & Molecular Biology - In this study, the authors show that the splicing order of multi-intron-containing transcripts is predetermined and controlled in part by the...

www.nature.com
@fiddle
Stirling Churchman
@fiddle
2 years
Splicing of human introns could occur in any order across an RNA, which combinatorially adds up to thousands of possible splicing orders for a typical transcript. Are all orders used? Read our latest preprint by @Karine_Choquet to find out! (1/6)
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10 years
My first tweet from 2007 says "Thinking about RNA polymerase". 7 years later, and it's all I think about.
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4 years
20 years ago, it was daunting to be a physics PhD student as only 10% were women. Remarkably, the statistic has not changed since. So proud of my husband @andystrominger whose high energy theory group is half women. Read about his mentoring style @GenHET_
ANNEX-Oct 2020-MENTORING.pdf
drive.google.com
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7 years
I pulled up my thesis defense talk from ten years ago and realized I put shadows under my slide titles. <shudder> I've come a long way!
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4 years
If you’ve ever seen me give a talk, you’ve probably seen one of my brother’s paintings. If you’re in New York between now and April 18, I highly recommend his show at @MatthewMarks Gallery. I loved the layers of beauty, emotion and meaning in each piece!
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7 years
My graduate advisor told us that luck is the ability to recognize opportunity when it arrives. I like thinking of it that way.
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1 year
Does Pol II pausing control cell differentiation? @Danyajane , in collaboration with @bloodgenes , studied Pol II pausing and SPT5 in human erythropoiesis and found Pol II pausing temporally coordinates cell cycle progression and erythroid differentiation.
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RNA Polymerase II pausing temporally coordinates cell cycle progression and erythroid differentia...

The controlled release of promoter-proximal paused RNA polymerase II (Pol II) into productive elongation is a major step in gene regulation. However, functional analysis of Pol II pausing is diffic...

www.medrxiv.org
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3 years
@caitvw You can stop your search because there is no better lab webpage than @maxwellheiman 's page:
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5 years
We show that splicing completes after many kilobases are transcribed, but sooner in flies than humans. We find that splicing does not always follow the order of transcription and that human splicing is coordinated across proximal introns. Much more in the pre-print! (4/4)
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6 years
Looking forward to celebrating Stephen Hawking’s life and science today at Westminster Abbey. He’ll have great company between Newton and Darwin.
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8 years
Our first biorxiv paper: FIDDLE accurately predicts datasets, like TSS annotation, from data you already have. @Umut1Eser
@biorxivpreprint
bioRxiv
@biorxivpreprint
8 years
FIDDLE: An integrative deep learning framework for functional genomic data inference #bioRxiv
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3 years
Curious about black holes? Check out: Black Holes: The Edge of All We Know on @netflix featuring my husband @andystrominger who explains why he thinks about them 24 hours a day, seven days a week, even when he’s brushing his teeth and when he’s dreaming.
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‘Stranger than anything dreamed up by sci-fi’: will we ever understand black holes?

In the new documentary Black Holes: The Edge of All We Know, the work of Stephen Hawking and others in trying to figure out a mystery for the age is put under the spotlight

www.theguardian.com
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5 years
I strongly approve and support the @harvardmed diversity statement released today. It reflects the HMS I know and the leadership of Dean @G_Q_Daley . Thanks to all at HMS who helped put it together and I look forward to helping fulfill its promise!
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7 years
Feeling stupid is so important! Highly recommended.
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3 years
Bird watching out my office window! A red-tailed hawk couple is raising eyas in the nest in the bell tower of the @BostLatinSchool . @HMSGenetics @harvardmed
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5 years
I had a great time presenting to all the Damon Runyon fellows. I have such fond memories of the retreats. And I got the most questions I’ve had in a while! Thanks for all the stimulating conversations!
@DamonRunyon
Damon Runyon Cancer Research Foundation
@DamonRunyon
5 years
We’re honored to have L. Stirling Churchman, PhD, of @HarvardMed as today’s alumna speaker. She is speaking on the “Dynamics of gene expression and academic careers” @ChurchmanLab #DamonRunyonRetreat
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@fiddle
Stirling Churchman
@fiddle
5 years
One week left to submit your abstract to the EMBO workshop on Chromatin and Epigenetics! Check out the speakers! We worked hard to include new and exciting directions in chromatin biology. Hope to see you there!
@EMBLEvents
EMBL Events
@EMBLEvents
5 years
Submit your abstract by 13 Feb for the EMBO Workshop: Chromatin and Epigenetics, #EMBOchromatin #chromatin @EMBOevents -
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Stirling Churchman
@fiddle
3 years
Exited for @HMSGenetics holiday party where we’re testing how elevated our palates are! Aliquots of liquids, from wine to whiskey, have been distributed and now we guess what they are and which are expensive! Thanks to @_emmarosewest , @vonshannon and @BrendanSmalec for organizing
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Stirling Churchman
@fiddle
4 months
Celebrating Jack Strominger’s 99th New Year’s Eve! Happy New Year to everyone! May we all enjoy so many.
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Stirling Churchman
@fiddle
3 years
Join us! We are looking for a Research Assistant to work on various projects on transcription, mRNA splicing, and mtDNA expression/maintenance. Join our fun, supportive and stimulating lab environment! Feel free to contact me with questions/interest.
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Stirling Churchman
@fiddle
6 years
Looks like the Eagle disagree with Watson and Crick and prefer Z-DNA!
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Stirling Churchman
@fiddle
2 years
About a month ago, someone here described how a failed experiment was troubleshot by a service that will sequence a whole plasmid for $25. I lost the tweet -- does anyone know of a cheap and fast plasmid sequencing service?
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Stirling Churchman
@fiddle
7 years
Chromatin Haiku If you reveal yourself here A drink awaits you @ChromatinHaiku @TriggerLoop #moet2017
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Stirling Churchman
@fiddle
2 years
Exceedingly excited that my sibling, Leidy Churchman, was selected to participate in the Whitney Biennial this year. Apr 6 - Sept 5. If you are in New York, please check it out!
@whitneymuseum
Whitney Museum
@whitneymuseum
2 years
The 2022 Whitney Biennial artist list is here. We're excited to announce the 63 artists that will be featured in Whitney Biennial 2022: Quiet as It's Kept. Co-curators David Breslin and Adrienne Edwards give us a sense of what's to come. The full list:
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Stirling Churchman
@fiddle
4 years
Congratulations on your ML approach - great that it makes cryoEM even better and easier! And happy to hear my twitter habit lead to something worthwhile :)
@mcianfro
Michael Cianfrocco
@mcianfro
4 years
This is many years in the making! I remember tweeting about this 3.5 years ago when @fiddle posed the question - can't we tackle this with machine learning?
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Stirling Churchman
@fiddle
2 years
Thanks to #RNA2022 for inviting my student @BrendanSmalec to present his and @robertietswaart work to measure the rates of “RNA flow” across the cell, from chromatin to polysomes!
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Stirling Churchman
@fiddle
8 years
The Churchman lab has a new model organism! Please help us welcome Chlamydomonas reinhardtii!
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Stirling Churchman
@fiddle
5 years
So proud of my student Dr. Heather Drexler for defending her thesis today!
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Stirling Churchman
@fiddle
7 years
@DrAnneCarpenter Once in your career you might get scooped or screwed but mostly, the science was better and you were happier than if you never shared.
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Stirling Churchman
@fiddle
4 years
Come join us at @harvardmed ! Reach out to me if with any questions especially if you’re wondering whether to apply.
@HMSGenetics
HMS Genetics Department
@HMSGenetics
4 years
Blavatnik Institute @ HMS has launched a junior faculty search in the Life Sciences - including Genetics - with a specific goal of advancing diversity in scientific research and discovery. Applications invited for up to 4 positions.
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Stirling Churchman
@fiddle
6 years
I'm at a string theory/gravity workshop in western UK where I hoped to hide away and work on manuscripts. Now they have insisted that I give a talk. Advice on explaining gene regulation to theoretical physicists?
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Stirling Churchman
@fiddle
3 years
Anyone have advice for how to educate family members who trust emails from anti-vaccine groups more than science? Without losing your cool?
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Stirling Churchman
@fiddle
2 months
Exciting to be back @CSHL for the #cshlsysbio general expression meeting! Love seeing our data generated by @mtcicero26 and @stergachislab on the poster and abstract book!
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Stirling Churchman
@fiddle
3 years
Very strange to attend a conference and watch your pre-recorded talk!
@MicrobioSoc
Microbiology Society
@MicrobioSoc
3 years
First up in our #FlemingShowcase , Dr Stirling Churchman presents her talk on ‘Orchestrating gene regulation across the genome and across the cell’. Read more about Professor Churchman: @fiddle #WhyMicrobiologistsMatter
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Stirling Churchman
@fiddle
7 years
Our review on the RNA Pol II CTD is out. Congrats to @KharMT ! The code and beyond:
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Stirling Churchman
@fiddle
4 years
@HarmitMalik @NateSilver538
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Stirling Churchman
@fiddle
3 years
@NCITomMisteli Many people aren't on Twitter so you don't reach the whole community here anyway. The best way to "self-promote" is to give talks at meetings, publish solid papers, put manuscripts on bioRxiv, be a good citizen in the scientific community, train people well.
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Stirling Churchman
@fiddle
7 years
Our new review... Pause & go: from the discovery of RNA polymerase pausing to its functional implications
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Stirling Churchman
@fiddle
7 years
Disappointing! 1) no ladder, is flight the expected length?, 2) show full blot please! 3) needs a loading control, 4) replicates required.
@arjunrajlab
Arjun Raj
@arjunrajlab
7 years
Like, here's the mol bio mechanistic model of an airplane @YSPTSPS
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Stirling Churchman
@fiddle
7 years
Powerful! All departments should do this!
@TonyZador
Tony Zador
@TonyZador
7 years
Immigrants: Keeping American Science Great!
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Stirling Churchman
@fiddle
3 years
nano-COP lets you study nascent RNA processing, from transcription-splicing coupling to the order of intron removal across long isoforms. Read more in @hopemerens ’s blog post on the protocol. (3/3)
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A Long Look into the Early Life of RNA

Nanopore Analysis of Co-Transcriptional Processing (nano-COP) combines stringent nascent RNA purification and direct RNA long-read sequencing to provide an in-depth look into RNA dynamics during...

communities.springernature.com
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Stirling Churchman
@fiddle
6 years
Grant writing with a view! @timp0 @psmibert
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Stirling Churchman
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6 years
Great dinner in Dresden for the ‘Biophysics in the nucleus’ meeting. Great talks today about nucleosome remodeling, phase separation, nuclear stokes fluids @PetersonLab @taekjip @Cisse_lab
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Stirling Churchman
@fiddle
6 years
I had a great visit yesterday to the MRC Human Genetics Unit. Thanks to my host, @wendy_bickmore , I have office view envy! Views of Edinburgh castle and Fettes College.
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Stirling Churchman
@fiddle
6 months
I had a great visit to @karolinskainst yesterday! Thank you @mitopinionated for hosting me and the fun dinner!
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Stirling Churchman
@fiddle
3 years
Interested in the sequence determinates of Pol II pausing? Looking for pauses in your NET-seq data? Check out this out 👇
@mayer_lab
Mayer Laboratory
@mayer_lab
3 years
Our manuscript on widespread DNA sequence induced transcriptional pausing is now published. In this study, we also developed a new NET-seq protocol variant and a peak caller for nucleotide-resolution occupancy data. You can find the manuscript here:
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Stirling Churchman
@fiddle
8 years
Mary's paper on synchronized mitochondrial and cytosolic translation programs is online!
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Stirling Churchman
@fiddle
1 year
I'm resurrecting my career as a radio DJ for one time show tonight. Check out my mix at 19:00 CET/13:00 EST on Retreat Radio out of Malmö, Sweden. Thanks to @MarijanaCroon for hosting me! Expect sounds similar to my @KZSU days.
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Stirling Churchman
@fiddle
7 years
Global role of BET family proteins in txn elongation. Wonderful collaboration with @georg_e_winter and @jaybradner !
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Stirling Churchman
@fiddle
5 years
Chalk talks are off to a great start at our annual retreat!
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Stirling Churchman
@fiddle
5 years
At the end of the day, asked once again if I have any questions, I respond with what I planned to google later: “what is genetics?” That’s what happens when a physicist interviews in a genetics department! 7 years in, I have a vague idea of the answer!
@GlobalHigherEd
Kris Olds
@GlobalHigherEd
5 years
What’s your terrible/surprising academic job interview memory?
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Stirling Churchman
@fiddle
7 years
@DrAnneCarpenter My feeling is that being open in science makes the whole job more rewarding and more fun.
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