David Steensma, MD @DavidSteensma Twitter profile | Pikagi

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David Steensma, MD

@DavidSteensma

24,928

Followers

463

Following

2,111

Media

7,577

Statuses

Hematologist-oncologist. @AjaxThx CMO. Former Edward P. Evans Chair in MDS @DanaFarber , @HarvardMed & @MayoClinic faculty, @NovartisScience hematology head.

Cambridge, Massachusetts, USA

Joined August 2014

Don't wanna be here? Send us removal request.

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@DavidSteensma

David Steensma, MD

4 years

Since the number of #HematologyTweetstory threads has grown (these are about the intersection of history, etymology, science and clinical practice), I made an index so readers can find ones they are interested in:

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"HematologyTweetstory" Index

Sheet1 Tweetstory Number,Topic,Date Posted,Link 1,Ring sideroblasts and Prussian blue,October 6, 2019,https://twitter.com/DavidSteensma/status/1180836386875887616,*For these first few the "Tweetsto...

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Last Seen Profiles

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@bravowivesclub

@DavidSteensma

David Steensma, MD

3 years

Had a paper published last week in a good journal - then got an email from editor of a higher IF journal saying it was a great paper, next time we should send stuff like that to them - I pointed out we had actually first submitted that paper to his journal & it was rejected 🙄

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@DavidSteensma

David Steensma, MD

1 year

I once met the daughter of a famous cardiologist. I said: that must have been an interesting home to grow up in. She looked sad and said, “The main thing I remember about my childhood is that my Dad was never around.”

@SahilBloom

Sahil Bloom

1 year

This Reddit post hit me hard.

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@DavidSteensma

David Steensma, MD

5 months

Did you ever wonder why our marrow is located inside of our *bones*, #MedTwitter ? There’s no a priori anatomical reason it should be sited there. Blood cells could form in our spleens & livers, as they do during our fetal lives; or elsewhere, as in some animals. Let’s discuss! /1

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@DavidSteensma

David Steensma, MD

5 years

Weirdest use of #EMR : I prescribed a dog for a patient with anxiety. (Patient lives in public housing, so needed prescription.) Dog was beloved & helped greatly. Sadly, dog died in a fire. Patient asked for new dog at next visit. Clicked refill button on "One Dog" prescription.

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@DavidSteensma

David Steensma, MD

3 years

This is how the door switches are labeled in our garage. My longsuffering wife puts up with a lot

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@DavidSteensma

David Steensma, MD

2 years

A few years ago a mentally ill man threatened to kill me after his wife’s complex karyotype secondary AML relapsed post allogeneic transplant. The days until he was apprehended and admitted to an inpatient psychiatric institution were one of the scariest times of my life./1

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@DavidSteensma

David Steensma, MD

3 years

Aspirin continues to be the most widely used anti-platelet agent, 125 years after its synthesis. But where did it come from - and why do we give it in such weird doses (e.g. 81, 162 & 325 mg) – at least in the United States? #HematologyTweetstory 35 will answer these questions./1

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@DavidSteensma

David Steensma, MD

4 years

Yesterday 3 patients I had cared for over years died, on the same day; 1 in the ICU, 2 at home under hospice care. The youngest was in her 20s. I was almost numb with grief last night thinking about all the lost potential, the children left behind, their collective suffering./1💔

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@DavidSteensma

David Steensma, MD

3 years

I feel like I should save the editorial email exchange and include it as Supplementary Material in the next manuscript submitted to that journal - add it as Supplementary Table 9Facepalm or Supplementary Figure 6GoodGrief

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@DavidSteensma

David Steensma, MD

4 years

#HematologyTweetstory 10: how did the 5 major #nucleobases get their names? This is slightly tangential to hematology, admittedly, but is a cool story that I’ve been aching to tell since I went through an intense etymology phase many years ago (still have lots of dusty books)./1

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@DavidSteensma

David Steensma, MD

5 years

I covered the pager of a young female colleague this weekend & it was... eye-opening. First, she gets a lot of pages, some about stuff I wouldn't be called with. Second, *everyone* - ER, Admitting, lab, nurses - paged with her first name. I get "Hey David" sometimes, not always.

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@DavidSteensma

David Steensma, MD

4 years

Nerdy confession: to remember what locker I’ve used at the gym, I only put my bag in lockers w/ numbers corresponding to #myeloid CD markers - 13, 33, 34, 117, 123. (Today: CKIT.) In a pinch, I’ll use a monocytic locker like 68. Once even those were full; I had to go T cell! 😬

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@DavidSteensma

David Steensma, MD

3 years

When I started in medicine, I had no idea how much of clinical practice would be consumed by replenishing potassium and magnesium.

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@DavidSteensma

David Steensma, MD

2 years

These website CAPTCHA validations to try to distinguish humans from robots are just getting insanely difficult 😉 #Hematopathology #Medtwitter #CMML @sanamloghavi @KMirza

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@DavidSteensma

David Steensma, MD

5 months

TL;DR: blood stem cells are damaged by radiation. Seawater doesn't allow gamma/neutron radiation to pass; air does. Unlike sea creatures, land animals would have stem cell damage without shielding. Bone's a good radiation shield. So land animals have blood stem cells inside bone.

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@DavidSteensma

David Steensma, MD

2 years

I had not thought of being a hematologist-oncologist as a profession at risk for workplace violence, but in the sick society we currently live in, and with the foolishness and inaction of politicians, every profession is at risk for violence - every American is, in every place./4

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@DavidSteensma

David Steensma, MD

3 years

Long ago, a mentor ⁦ @MayoClinic ⁩ suggested keeping a folder of thank you notes and cards sent by patients & family members, to look at on the bleakest days and remember having helped someone. This was good advice. While cleaning out my office, I found the most recent one.💕

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@DavidSteensma

David Steensma, MD

2 years

It doesn’t matter how empathic you are as a physician, how skilled you are, how good a communicator you might be. People are going to have bad outcomes - and some patients or family members will be angry, usually not at you but rarely at you, and some even will be violent./5

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@DavidSteensma

David Steensma, MD

2 years

Feeling terrible about asking overworked clinicians to represcribe & redo prior auths for all of family’s meds because our insurance changed preferred pharmacies on January 1. Should be a moratorium on Prior Authorizations until the end of the pandemic (& preferably forever…) 😢

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@DavidSteensma

David Steensma, MD

2 years

And you know what the worst part was? He wasn’t there for her when she needed him. 💔

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@DavidSteensma

David Steensma, MD

4 years

I am self-diagnosing with advanced, relapsed/refractory Outrage Fatigue, 2020 subtype.

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@DavidSteensma

David Steensma, MD

5 years

That yesterday’s monthly faculty meeting began with applause for a faculty member who just won the #NobelPrize , and ended with discussion of missing Prior Authorizations and how we need to extend clinic hours, perfectly encapsulates the triumph and absurdity of modern oncology 😜

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@DavidSteensma

David Steensma, MD

6 years

You were a retired med school dean - so sick the first day I met you, I had to admit you to the hospital. Two days later, you died. Your last conscious act: allowing 1st year med students interview you & correcting their spleen exam. A teacher to the end. #ShareAStoryInOneTweet

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@DavidSteensma

David Steensma, MD

2 years

The number of patients over the years who said, when consenting to hematology-oncology clinical trials, “Even if it doesn’t help me, it might help someone else” gave me enough hope for humanity to last the rest of my days #MedTwitter #altruism

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@DavidSteensma

David Steensma, MD

4 years

#HematologyTweetstory 32: lymph nodes with names. There’s also a major personal announcement in this thread. We each have lots of lymph nodes: an estimated 500-600 (Image: @MayoClinic ). Like stars, they cluster. (Did you ever think of your axilla as a lymphatic “galaxy”?)🙂/1

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@DavidSteensma

David Steensma, MD

2 years

I was also grateful that Massachusetts has some of the strictest gun laws in the US, as it emerged the man had lost his firearms due to a previous incident at Logan airport and a felony at another site, so all he had access to were some hand grenades./3

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@DavidSteensma

David Steensma, MD

4 years

Why is blood red? This color has such a rich symbolism in human history - in art, literature, religion (e.g., Catholic Cardinals wear red robes to symbolize the blood of Christ). #HematologyTweetstory28 considers the color of human blood...and how it might have been different./1

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@DavidSteensma

David Steensma, MD

4 years

The head of the United States Food and Drug Administration (!) @SteveFDA does not understand the difference between relative and absolute risk reduction -- a basic, fundamental concept in medicine, statistics and clinical trial interpretation. It just gets worse and worse.😢

@US_FDA

U.S. FDA

4 years

"A 35 percent improvement in survival is a pretty substantial clinical benefit," FDA Commissioner @SteveFDA said in relation to the convalescent plasma emergency use authorization issued today.

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@DavidSteensma

David Steensma, MD

4 years

#HematologyTweetstory 8: Auer rods! These peculiar cell inclusions are a worrisome finding, defining an immature blast cell as one of myeloid lineage… and they are also probably mis-named. This image is from a chapter I wrote for a board review book @MayoClinic circa 2007. /1

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@DavidSteensma

David Steensma, MD

4 years

If the randomized clinical trial to test this hypothesis in #COVID19 is not called the #COVFEFE trial - ie COVid Field Experiment For Emerging treatments, then we will have have missed a tremendous historical opportunity @marklewismd

@realDonaldTrump

Donald J. Trump

@realDonaldTrump

4 years

HYDROXYCHLOROQUINE & AZITHROMYCIN, taken together, have a real chance to be one of the biggest game changers in the history of medicine. The FDA has moved mountains - Thank You! Hopefully they will BOTH (H works better with A, International Journal of Antimicrobial Agents).....

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@DavidSteensma

David Steensma, MD

4 years

Just submitted my last-ever book chapter! Never again will I allow myself to be talked into that amount of effort for something that will be dated by the time it is published, few will read, makes money for publisher but not the authors, and counts for almost zero academically.🙁

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@DavidSteensma

David Steensma, MD

3 years

Twice in my career I have been asked by a journal to review my own submitted manuscript. I dutifully alerted the editor both times, but in retrospect that feels like a huge missed opportunity...

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@DavidSteensma

David Steensma, MD

3 years

It is often said that Marie Skłodowska-Curie died of "aplastic anemia." Try Googling it; you'll find many hits. But I am not so sure. She died on July 4th, 1934, at a sanatorium called Sancellemoz, in Passy, Haute-Savoie, France, after a long illness. #aplasticanemia #MDS /1

@NobelPrize

The Nobel Prize

3 years

Marie Curie died of aplastic anaemia on 4 July 1934, a result of years of exposure to radiation through her work. Even today her laboratory notebook from 1899-1902, is radioactive and will be for 1,500 years.

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David Steensma, MD

2 years

I was grateful that the hospital offered a round-the-clock security detail during that time, and for other support they provided. They took the threat seriously because a few months earlier Dr Mike Davidson had been killed by a disgruntled family member in the same hospital./2

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@DavidSteensma

David Steensma, MD

5 years

I don't normally tweet personal stuff, but this is actually another example of the lunacy of our US healthcare system. In June, one of our kids was a passenger in a single-vehicle car vs telephone pole MVA in a car driven by a classmate. She was taken to the nearest hospital. /1

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@DavidSteensma

David Steensma, MD

4 years

#HematologyTweetstory 17 is about el bazo, die Milz, селезенка, तिल्ली - whichever name you use for the mysterious organ that in English is the spleen. Ask the proverbial man on the street, “What does the spleen do?”; he won’t know. (Image: Gray's Anatomy; the book, not TV show.)

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@DavidSteensma

David Steensma, MD

4 years

Since so many twitter posts are about people being "humbled" etc by grants/promotions I feel duty-bound to post how humiliated I am that our latest @NIH co-PI R21/R33 submission wasn't scored.😜Critiques? Usual mix of valid stuff, erroneous statements & unsubstantiated opinion.🤷‍♂️

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@DavidSteensma

David Steensma, MD

2 years

K-562. It was the first human cell line I ever tried to grow in culture, during training @MayoClinic . It was also the first immortalized myeloid leukemia #cellline , published @BloodJournal way back in 1975. What does the K stand for? #HematologyTweetstory 37 is on cell lines./1

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@DavidSteensma

David Steensma, MD

5 years

There is an interesting history behind these cells, so familiar to hematologists & pathologists: ring (formerly 'ringed') sideroblasts. While most commonly associated with #MDS or inherited disorders like #XLSA , they can also result from ethanol or TB drugs - even hypothermia./1

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@DavidSteensma

David Steensma, MD

5 years

I think most Americans don't want a political revolution; we want reforms, common sense changes, an end to an unsustainable system that requires 10+ administrators per clinician and allows huge profit-making hospital/pharmacy systems charging "what the market can bear"./7End

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@DavidSteensma

David Steensma, MD

5 years

You know you are a #hematologist when your child adds #splenomegaly to her "pancake person" at the make-your-own-flapjack restaurant... @ASH_hematology @marklewismd

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@DavidSteensma

David Steensma, MD

3 years

Publishing is such a rigged game. We published this book in 2019. Hundreds of hours of work. Has sold >5,000 copies; readers have found it useful. Haven’t received a penny of royalties, since I was “set up incorrectly in the system” & @wileyglobal claim they can’t do anything.🤬

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@DavidSteensma

David Steensma, MD

5 years

And yes, I realize the world has far more important concerns, ranging from Ebola in the Congo to plastics filling the oceans to migrant crises to melting icecaps... but sometimes it is interesting/enlightening to step into someone else's shoes and see what they have to deal with.

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David Steensma, MD

4 years

In December, on my 50th birthday, I’ll be starting as Global Hematology Lead for @Novartis , based in the Translational Clinical Oncology/early drug development group at NIBR in Cambridge MA and working to bring new treatments to patients with conditions such as those above./22

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David Steensma, MD

5 years

A sign of #KonMari cultural penetration: patient said he’d be glad to have kidney removed because it “no longer sparks joy” after seeing the tumor on the scans. Now we just need the surgeons to thank it for its years of service at the time of resection... @DrChoueiri

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@DavidSteensma

David Steensma, MD

4 years

I'm often asked by patients, family members, referring physicians, or clinical trial sponors: "So how do you guys pick which clinical trials to do, anyway?" There are hundreds of trials in hematologic malignancy ongoing... how to choose? Here are some thoughts. Image: @NIH

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@DavidSteensma

David Steensma, MD

2 years

This has to change./6

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@DavidSteensma

David Steensma, MD

1 year

Today is my last day as Global Hematology Head @NovartisScience $NVS. I've met many terrific people and learned much in the last 3 years, and hopefully have influenced some programs & collaborations positively. I'm grateful for the experience and look forward to the next chapter!

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@DavidSteensma

David Steensma, MD

4 years

#HematologyTweetstory 9: the “Philadelphia” chromosome! Whole books have been written about this saga; we’ll focus on some of the most interesting highlights. A shout-out to @LuskinMarlise – former @PennMedicine fellow & now @DanaFarber colleague - for suggesting this topic. /1

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@DavidSteensma

David Steensma, MD

3 years

Got this gem from Reviewer 2 (actual Reviewer 2!) today in an manuscript that apparently transgressed a personal agenda by using the term “hypomethylating agent” - a widely used term, with thousands of PubMed uses & 191K hits on Google. Don’t be that guy. #pompousacademic

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@DavidSteensma

David Steensma, MD

2 years

Please please speakers just report AE data and stop editorializing that the drug was safe and well tolerated #ASH21

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@DavidSteensma

David Steensma, MD

8 months

I’m excited to have started this new role as Chief Medical Officer of ⁦ @AjaxThx ⁩, focused on developing new medicines for patients with myeloid neoplasms. It is a terrific team and brilliant group of founders led by ⁦ @rosslevinemd ⁩ #MPNsm #JAK2

Ajax Therapeutics Appoints Dr. David Steensma as Chief Medical Officer - AJAX

– A leading expert in hematologic malignancies with more than 25 years of oncology clinical and research experience, Dr. Steensma joins Ajax as its lead JAK2 inhibitor advances to the clinic – New...

www.ajaxtherapeutics.com

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@DavidSteensma

David Steensma, MD

4 years

Just had to do a Prior Authorization request for an INFLUENZA VACCINE (!) and what the heck is this world coming to 🤬 (It was approved, for 1 year)

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@DavidSteensma

David Steensma, MD

2 years

The most egregious so far #ASH21 was an abstract in which 98% of patients had Grade 3/4/5 adverse events, >25% died or discontinued therapy due to AEs...yep, still described as well-tolerated. When something is "not well tolerated" you know it must have been really really bad.

@DavidSteensma

David Steensma, MD

2 years

Please please speakers just report AE data and stop editorializing that the drug was safe and well tolerated #ASH21

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@DavidSteensma

David Steensma, MD

3 years

Am going to miss walking back and forth across this spirit-lifting “Bridge of Hope” between @DanaFarber outpatient and @BrighamWomens and @DanaFarber inpatient hospital, where someone took the time to hand-paint dozens of birds each carrying a medicinal plant

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@DavidSteensma

David Steensma, MD

2 years

I took an @Uber home from the airport and my bill had a fuel surcharge on it because of the current price of gasoline. The driver’s car was a @Tesla … 🤷

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@DavidSteensma

David Steensma, MD

5 years

Humbling how eager some patients are to leave a legacy and advance research for their disease. After a final visit today with a patient who was failed by a Ph.1 trial, she asked: was there any more blood or tissue she could still donate for research, to maybe help someone else?😢

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@DavidSteensma

David Steensma, MD

2 years

As I check in for my flight ✈️ back home to Boston tomorrow, excited by so much new data from #ASH21 (and with a long list of talks to watch at home), I am mulling over three key take-aways. First: collectively we are all suffering from a colossal amount of loss and trauma./1

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@DavidSteensma

David Steensma, MD

4 years

Look at this lung! 🫁😲 Removed from a 20 year old woman who was previously healthy before #COVID19 . I know I'm just preaching to the choir here given all the wicked smart people who follow me on Twitter, but hey - let's all keep wearing masks for a while, OK? 🙂 @VincentRK

@tmprowell

Tatiana Prowell, MD

4 years

The US has performed its first double lung transplant for lung damage caused by #COVID19 . The recipient is a 20 yr old woman. She remains on a ventilator at this time. The damage inflicted by #SARSCoV2 is stunning. Via @nytimes

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@DavidSteensma

David Steensma, MD

4 years

#HematologyTweetstory 23: a thread on how the confusing "myelo-" nomenclature arose. Myelodysplasia, AML, myelofibrosis. Myeloma. Myelomeningocele, poliomyelitis, and other neurologic conditions. Osteomyelitis (depicted). They *sound* connected - but are unrelated. #MDS #MMsM /1

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David Steensma, MD

4 years

In the holiday spirit, it’s time for #HematologyTweetstory 11: the Howell-Jolly Body!🎄A friend @UChicagoMed , Brian Nelson, sang “It’s A Holly Jolly Christmas” in 1st year med school, forever linking these erythrocyte bodies to Christmas for me. (Image Source: @ASH_hematology )

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@DavidSteensma

David Steensma, MD

4 years

#HematologyTweetstory 14 is about blood #neutrophils : where does the term “left shift” come from? We use this term devoid of its original context, sometimes based on lab reports displayed in a column! Attached left-shifted blood & marrow pics are from @ASH_hematology Image Bank/1

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@DavidSteensma

David Steensma, MD

4 years

By far the nerdiest costume I ever wore was for a Halloween party during residency: I drew alpha & dense granules on dozens of paper plates, taped them to myself, and went as a "platelet clump". After 22 years, I now feel enough distance to confess this to the Twittersphere.😬

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@DavidSteensma

David Steensma, MD

5 years

In the last 2 weeks, I’ve requested >100 units just like this one for my inpatient leukemia service & outpatients. As hematologists, we prescribe blood so commonly it gets easy to take for granted and forget how amazing a #transfusion is. Grateful for donors, blood bankers, etc.!

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@DavidSteensma

David Steensma, MD

4 years

In this context, so many of the disputes & petty jealousies of academic medicine that fill hallway discussions & Twitter feeds just seem so irrelevant. It is too easy to get lost in minutiae... feels important to rise above that & work to keep fewer people from dying too young./3

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David Steensma, MD

4 years

My recent DNA #nucleobase etymology thread turned out to be surprisingly popular. So now let's do the amino acids -- #HematologyTweetstory 12. This pretty chart of the #aminoacids is from “BioNinja”:

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@DavidSteensma

David Steensma, MD

3 years

@marklewismd Last time I renewed ACLS I was paired with a cancer immunotherapy pioneer. We did a Megacode; the mannequin had a rhythm & return of circulation and was about to go off to the imaginary ICU. So the instructor said “OK what drug would you give next?” And he said: “ipilumumab” 😜

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@DavidSteensma

David Steensma, MD

1 year

Four stages of scientific meetings, across a career: 1) You recognize many people, few recognize you. 2) You know many, and many know you! 3) Many know you, but you recognize few. 4) You know no one; few recognize you. Echoing melancholy Jacques in “As You Like It” for #ASH22 .

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@DavidSteensma

David Steensma, MD

5 months

One body tissue does a great job of shielding from gamma/neutron radiation: bone. Bone hydroxyapatite attenuates radiation similarly to concrete - that's the basis of radiographs. Animals whose HSCs randomly ended up inside bone would have their HSCs protected from radiation./11

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@DavidSteensma

David Steensma, MD

4 years

#HematologyTweetstory 18: bone marrow aspiration & trephine biopsy - critical diagnostic tests in evaluating suspected hematologic disease. Here’s a diagram of the procedure for patients (from @MayoClinic ) & illustration of the basic concept from my then 6-year-old daughter.🙂/1

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@DavidSteensma

David Steensma, MD

4 years

Not a day goes by when someone doesn’t tweet about an academic promotion they’ve just received. I’m happy for y’all – but there's also been good discussion of late about #careerism too, and at times it all feels like a big - trivial - game. A brief thread about academic ranks:/1

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@DavidSteensma

David Steensma, MD

4 years

Currently dealing with an insurer refusing to pay for cladribine for classic hairy cell leukemia (FDA approved in 1993), and I just can't even. That is like declining 3&7 for AML or R-CHOP for lymphoma. I'm not asking for moxetumomab pasudotox-tdfk or some other fancy sauce. 🤦‍♂️

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@DavidSteensma

David Steensma, MD

1 year

I’ve never posted a @tiktok_us link before, but this is a rare opportunity to observe one of the most poorly understood disorders in #hematology : Gardner-Diamond syndrome. This young woman's skin lesions first appear about 40 seconds in./1 #MedTwitter

TikTok · Nancy Morel

3.4M likes, 12.2K comments. “feel free to ask any questions 🤍”

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@DavidSteensma

David Steensma, MD

3 years

Academic medicine today: listening to a colleague present machine learning analysis of petabytes of @broadinstitute multiomics data, but leaving early to answer a Motorola pager 📟 then returning to clinic to sign faxed forms & learn the prescription printer🖨️is broken again 🤦‍♂️

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@DavidSteensma

David Steensma, MD

4 years

#HematologyTweetstory 21: the “CD” nomenclature. Musical CDs may be obsolete (though I still have a lot of them from college days; Paul Simon’s “Graceland” wins for most listens). Communicating clearly about blood cell surface markers? Here to stay.🙂 @ASH_Hematology #hemepath /1

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David Steensma, MD

4 years

I got 7 invites to review from journals today. I said no to all of them, as I had received >20 review requests in the last 2 weeks and already agreed to 5, and just can't keep doing this + everything else.This⬆️volume is going to be the end of the current publishing/review model.

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David Steensma, MD

4 years

Not an official #HematologyTweetstory , just a question for clinicians - and a brief discussion. Do you use a shorthand schematic like this to depict laboratory results, including complete/full blood count (CBC/FBC) results? How universal are they?

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David Steensma, MD

1 year

The fashion industry now being influenced by Big Glycoprotein 😉 #MedTwitter

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David Steensma, MD

4 years

#HematologyTweetstory 34: Vitamin K. This tale includes 2 larger-than-life characters, self experimentation, & bloody cows. Also, yours truly was once *so* dedicated to hematology history that he drove to rural Wisconsin to search local property records related to this story.😉/1

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David Steensma, MD

4 years

To celebrate getting a @dunkindonuts Breakthrough Grant today to study clonal hematopoiesis in women with ovarian cancer (PI: Rebecca Porter @danafarber , w/ her mentor Ursula Matulonis), I recreated the classic CHIP/ARCH "fish plot" using Munchkin donut holes to represent HSCs.🙂

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David Steensma, MD

5 years

Time for #hematology - #hematopathology - #history #tweetorial 4: the striking Pelger-Huët anomaly! These curious cells, sometimes mistaken for neutrophil bands, can be inherited; if acquired, they are often a sign of #MDS . I took this photomicrograph of a characteristic example./1

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David Steensma, MD

7 months

It’s unsettling to see an instrument you had in your lab not so very long ago now in a museum exhibit as an “historical artifact” 😳

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David Steensma, MD

5 months

My longtime friend Bob Gale & 2 radiobiology expert colleagues (James Welsh & P. Andrew Karam) recently published a paper @LeukemiaJnl highlighting how “ontogeny recapitulates phylogeny”, with migration of embryonic hepatosplenic hematopoiesis to adult hematopoiesis in marrow./16

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David Steensma, MD

4 years

Outcomes for patients with cancer and marrow failure syndromes have improved in recent years, and I'm grateful for that - but we still have a long, long way to go. 😢 /4End

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David Steensma, MD

3 years

Love this - the medieval equivalent of #MedTwitter . 😊 It is an 11th century CE epitome of Ibn Sina’s classic Canon of Medicine, with all sorts of marginal notes - comments and recipes - written by various hands, some in Turkish, others in Arabic. Manuscript from @NLM_NIH ⁩.

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David Steensma, MD

4 years

Three Hematologists making a pilgrimage to the difficult-to-find 1866 gravesite of remarkable humanitarian and discoverer Thomas Hodgkin of #hodgkinlymphoma fame @MikkaelSekeres #rafaelbejar @ASH_hematology in the old Protestant cemetery in Jaffa

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David Steensma, MD

1 year

My kid is a student @michiganstateu and was so excited to have her first scientific paper published today. Now she’s sheltered under a piece of furniture, listening to sirens and shouting. Aren’t we tired of living this way, America? Almost every day, more senseless carnage. 😥🤬

@shannonrwatts

Shannon Watts

1 year

BREAKING: Police and other emergency services are responding to reports of an active shooting at Michigan State University in East Lansing. Witnesses say there are multiple victims.

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David Steensma, MD

3 years

Many people criticize the amount of basic science in medical education. But clearly *some* is needed, if only to avoid the embarrassment of having an MD after your name and >200K Twitter followers yet confusing plant cells (“cell walls”) and animal cells…🤦🏽‍♂️ #MedTwitter

@drmarkhyman

Mark Hyman, M.D.

3 years

You want to ensure your body has the fats it needs to construct high-quality cell walls. That means eating more omega-3 fats. Cell walls made from omega-3 fats are more flexible, which allows cells to respond more quickly to messages.⁣⁣

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David Steensma, MD

5 months

After all, zebrafish get along just fine making blood cells in their “kidney marrow”, keeping @leonard_zon 's lab running. Drosophila make blood-like cells in abdominal hubs, and frogs… frogs mix it up. Jeremiah Bullfrog & frog cousins make blood in kidneys, marrow, liver, etc./2

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David Steensma, MD

2 years

So cool: for decades, manufacture of the cancer drug #vinblastine has begun with low-yield extraction of precursors from Madagascar periwinkle. Now the Biosustainability group @DTUtweet has figured out how to do it at scale, from yeast. Broad implications.

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A microbial supply chain for production of the anti-cancer drug vinblastine

Nature - De novo microbial biosynthesis of vindoline and catharanthine using a highly engineered yeast and in vitro chemical coupling to vinblastine is carried out, positioning yeast as a scalable...

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David Steensma, MD

5 years

Since my recent "tweetorial" about the history of ring sideroblasts & Prussian blue seems to have been well received, I thought I’d follow up with the fascinating and sordid history of the term, “Refractory Anemia” (RA). (This ugly #MDS image is from a book I edited years ago.)/1

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David Steensma, MD

4 years

#HematologyTweetstory 33: hemoglobin variants, often said to be the most common single-gene genetic disorders in humans. “Disorders” is not entirely accurate, as many variants are clinically silent. We’ll focus on hemoglobinopathies; thalassemias are a story for another time./1

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David Steensma, MD

4 years

I wasn’t too excited about paying >$100,000 college tuition & fees this year for the kids to take some classes via Zoom, but at least this means the family cat is able to audit Physical Chemistry for free 😜

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David Steensma, MD

5 months

HSCs are also more radiosensitive than many other types of cells, possibly because of their rate of division and lack of differentiation. This radiosensitivity, which has been shown repeatedly in accidental and intentional human exposures, is an important part of our story./4

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David Steensma, MD

5 years

I benefited from an excellent medical education @UChicagoMed ~25 years ago. I learned a million facts & also how to take care of sick people in a complex/messy health system. But there were a few things that in retrospect would have been helpful to learn. A top 10 list:

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David Steensma, MD

3 years

"Be curious, not judgmental." (Walt Whitman) Some of the best advice for a physician - and any human being.

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David Steensma, MD

4 years

Dawn of #ASH19 ⁦ @ASH_hematology ⁩ - Safe & smooth travels to all heading to Orlando (especially French hematologists, who are dealing with a major strike disrupting travels today). Many people feel “impostor syndrome” at big meetings like this; remember, you belong @ASH too!

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@DavidSteensma

David Steensma, MD

1 year

@DGlaucomflecken Antiemetics for patients receiving emetogenic chemotherapy, targeted oncology medications for patients with the specific biomarker for which that medication is designed, and staging and surveillance scans following NCCN guidelines. Those should all be automatic but they aren’t.

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