Ziyad Al-Aly, MD @zalaly Twitter profile | Pikagi

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Ziyad Al-Aly, MD

@zalaly

29,217

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943

Following

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Physician-Scientist | Studying Long Covid #LongCovid Profile: …

United States

https://t.co/uCJoCHQ8nn

Joined February 2009

Don't wanna be here? Send us removal request.

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@zalaly

Ziyad Al-Aly, MD

4 months

My full testimony before the U.S. Senate Committee on Health, Education, Labor and Pensions Video here thanks to @luckytran 👇

@luckytran

Dr. Lucky Tran

4 months

"The burden of disease and disability from Long COVID is on par with the burden of cancer and heart disease. The best way to prevent Long COVID is to prevent COVID in the first place. There is no Long COVID without COVID." Brilliant testimony by @zalaly ! #HELPLongCovid

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Last Seen Profiles

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@zalaly

Ziyad Al-Aly, MD

8 months

True leadership by Austrian physicians “COVID-19 is not a cold. It is not influenza. It is a systemic, vascular-damaging disease that only spreads via the respiratory route, via aerosols. COVID is neither over, nor is it a harmless infection without consequences.” Read🧵below

@kniggem

Michael Knigge

8 months

🧵 Austrian physicans: "We CAN’T take responsibility for the constant, unmitigated infection of the population w/ a vascular-damaging, neurotropic virus like SARS-CoV-2, in which a previous infection provides no long-term protection vs future infection.”

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@zalaly

Ziyad Al-Aly, MD

1 year

Here is the latest from our team in @NatureMedicine Should you protect yourself from Covid-19 reinfection Yes! Reinfection is not benign; it is best to avoid it by @Bcbowe @Biostayan @zalaly A thread 🧵

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Acute and postacute sequelae associated with SARS-CoV-2 reinfection

Nature Medicine - A new analysis using US Department of Veterans Affairs databases showed that reinfection is associated with increased risk of all-cause mortality, hospitalization and a wide range...

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@zalaly

Ziyad Al-Aly, MD

4 months

Today I testified before the U.S. Senate Committee on Health, Education, Labor & Pensions I called for the establishment of a new multidisciplinary research institute to address Infection Associated Chronic Conditions Solving these requires a long-term coordinated approach

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@zalaly

Ziyad Al-Aly, MD

4 months

I am ready for the day. #LongCovid

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@zalaly

Ziyad Al-Aly, MD

1 month

Thanks to @people magazine for covering my piece on the Covid-19 and brain health COVID-19 poses a serious risk to brain health, even in mild cases, and the effects are now being revealed at the population level Link here:

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COVID Linked to Lower IQ, Poor Memory and Other Negative Impacts on Brain Health

Mounting scientific evidence reveals that being infected with SARS-CoV-2 — the virus that causes COVID — profoundly impacts brain health in many ways.

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@zalaly

Ziyad Al-Aly, MD

9 months

1/ 📣 New from my team in @NatureMedicine In a study of 6 million people, we examined risk trajectories of 80 components of Long Covid over 2 years post-infection 📌 Risks remained elevated for many Long Covid conditions even 2 years infection A 🧵

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Postacute sequelae of COVID-19 at 2 years

Nature Medicine - Analysis of data from the US Department of Veterans Affairs showed that 2 years after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, risk for most...

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@zalaly

Ziyad Al-Aly, MD

4 months

I talked to @TIME magazine about covid reinfection I wish we lived in a world where getting repeat infections doesn’t matter, but the reality is that‘s not the case Thanks to @AliceParkNY for this brilliant piece

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Is It Dangerous to Keep Getting COVID-19?

Common as they are, reinfections may have lasting impacts.

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@zalaly

Ziyad Al-Aly, MD

2 months

Mounting research shows that COVID-19 leaves its mark on the brain. My piece in @ConversationUS on two new papers in @NEJM , what we know so far and the implications. Link below

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Mounting research shows that COVID-19 leaves its mark on the brain, including with significant...

Two new high-profile studies add to the increasingly worrisome picture of how even mild cases of COVID-19 can have detrimental effects on brain health.

theconversation.com

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@zalaly

Ziyad Al-Aly, MD

4 months

The discussions we had on yesterday must translate into concrete actions that address the needs of people with #LongCovid , ME/CFS & other infection-associated chronic conditions We have a lot of work ahead It is all-hands-on-deck situation We need every one of you!

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@zalaly

Ziyad Al-Aly, MD

2 months

Revisiting the long-term health effects of Covid vs flu 3 key points 1. Covid is worse than flu 2. Covid is more multisystemic; flu is more respiratory 3. Both covid and flu cause more health loss in the long-term than what is evident around the time of acute infection…

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@zalaly

Ziyad Al-Aly, MD

2 years

The latest from our team in @NatureMedicine The long-term neurologic consequences of #COVID19 A thread 🧵 by @evanjxu @Biostayan @zalaly

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Long-term neurologic outcomes of COVID-19 - Nature Medicine

Individuals with COVID-19 are at an increased risk for an array of neurologic disorders at 12 months, even in those who were not hospitalized during the acute phase of the infection.

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@zalaly

Ziyad Al-Aly, MD

2 months

📣 New in @ScienceMagazine I teamed up with @EricTopol to write this #SciencePerspective on Long Covid Solving the puzzle of #LongCovid A long 🧵

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Solving the puzzle of Long Covid

Long Covid provides an opportunity to understand how acute infections cause chronic disease

www.science.org

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@zalaly

Ziyad Al-Aly, MD

2 months

My piece on Covid and brain health in Scientific American @sciam Even mild Covid can lead to significant decline in brain health

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COVID-19 Leaves Its Mark on the Brain. Significant Drops in IQ Scores Are Noted.

Research shows that even mild COVID-19 can lead to the equivalent of seven years of brain aging

www.scientificamerican.com

@sciam

Scientific American

2 months

Research shows that even mild COVID-19 can lead to the equivalent of seven years of brain aging

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@zalaly

Ziyad Al-Aly, MD

8 months

I told @ScienceMagazine that I advocate for boosters for all The argument that only the old and immunocompromised benefit from boosters misses the point that younger adults are also at risk of severe disease and will also benefit (albeit less than older)

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Should I get a COVID-19 booster?

Scientists continue to debate the pluses and minuses of extra doses of vaccine

www.science.org

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@zalaly

Ziyad Al-Aly, MD

4 months

On the invitation of Senator @SenSanders and @BillCassidy , I will be testifying before the U.S. Senate H.E.L.P Committee Hearing on #LongCovid Thursday Jan 18, 2024 Hearing Title: Addressing Long COVID: Advancing Research and Improving Patient Care 👇

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Addressing Long COVID: Advancing Research and Improving Patient Care | The U.S. Senate Committee on...

The U.S. Senate Committee on Health, Education, Labor & Pensions

www.help.senate.gov

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@zalaly

Ziyad Al-Aly, MD

1 year

Is covid still deadlier than the flu in 2023? The short answer is yes New from our team in @JAMA_current By @Biostayan Taeyoung Choi and @zalaly A thread 🧵

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Risk of Death in Patients Hospitalized for COVID-19 vs Seasonal Influenza in 2022-2023

This study uses data from the US Department of Veterans Affairs to assess whether SARS-CoV-2 remains associated with higher risk of death compared with seasonal influenza in fall-winter 2022-2023.

jamanetwork.com

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@zalaly

Ziyad Al-Aly, MD

7 months

People with Long Covid are being told: "it is in your head" This is NOT what the evidence says Terrific work by @VirusesImmunity @PutrinoLab & others in @nature provides objective evidence of significant differences in immune profiles of people with Long Covid vs controls…

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@zalaly

Ziyad Al-Aly, MD

1 year

Here is a new thread on our latest study without the full C word - to avoid suppression by the algo C=kovd Is C still deadlier than the flu in 2023? The short answer is yes New from our team in @JAMA_current By @Biostayan , Taeyoung Choi and @zalaly

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Risk of Death in Patients Hospitalized for COVID-19 vs Seasonal Influenza in 2022-2023

This study uses data from the US Department of Veterans Affairs to assess whether SARS-CoV-2 remains associated with higher risk of death compared with seasonal influenza in fall-winter 2022-2023.

jamanetwork.com

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@zalaly

Ziyad Al-Aly, MD

27 days

Delighted to see this!!!! @SenSanders releases a draft legislative proposal to address Long COVID $1 billion per year for 10 years. This is a significant step in the right direction. Thank you @SenSanders for your leadership!!!!

NEWS: Chairman Bernie Sanders Releases Long COVID Moonshot Legislative Proposal » Senator Bernie...

Before formally introducing the legislation, Sanders seeks input from patients and the medical community WASHINGTON, April 9 – Sen. Bernie Sanders (I-Vt.), Chair of the Senate Health, Education,...

www.sanders.senate.gov

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@zalaly

Ziyad Al-Aly, MD

4 months

Will be on @ChrisCuomo tonight to talk about #LongCovid 8:30 ET

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@zalaly

Ziyad Al-Aly, MD

1 year

Elevating my thread on the consequences of #reinfection Reinfection contributes additional risks in both acute phase and post-acute ( #LongCovid ) phase 2 infections are worse than 1 3 worse than 2 It is absolutely worth it to protect yourself from getting reinfection…

@zalaly

Ziyad Al-Aly, MD

1 year

Here is the latest from our team in @NatureMedicine Should you protect yourself from Covid-19 reinfection Yes! Reinfection is not benign; it is best to avoid it by @Bcbowe @Biostayan @zalaly A thread 🧵

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@zalaly

Ziyad Al-Aly, MD

1 year

Paxlovid can prevent #LongCovid The latest from our team in @JAMAInternalMed by @Biostayan @TaeyoungChoi93 @zalaly A thread

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Nirmatrelvir and the Risk of Post–COVID-19 Condition

This cohort study examines the association of treatment with nirmatrelvir in the acute phase of COVID-19 and risk of post–COVID-19 condition.

jamanetwork.com

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@zalaly

Ziyad Al-Aly, MD

4 months

3 key messages from our recent paper in @TheLancetInfDis 1. Covid is worse than flu Covid remains a much more serious threat to human health than the flu

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Long-term outcomes following hospital admission for COVID-19 versus seasonal influenza: a cohort...

Although rates of death and adverse health outcomes following hospital admission for either seasonal influenza or COVID-19 are high, this comparative analysis shows that hospital admission for...

www.thelancet.com

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@zalaly

Ziyad Al-Aly, MD

1 year

Outstanding and comprehensive review of #LongCovid A tour de force by the exceptional @ahandvanish @LisaAMcCorkell @julialmv @EricTopol who are in my view the true heroes of this pandemic In @NatureRevMicro

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Long COVID: major findings, mechanisms and recommendations

Nature Reviews Microbiology - Long COVID is an often debilitating illness of severe symptoms that can develop during or following COVID-19. In this Review, Davis, McCorkell, Vogel and Topol explore...

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@zalaly

Ziyad Al-Aly, MD

1 year

Compared to people who did not get reinfection, those with reinfection had 2 fold increased risk of death 3 fold increased risk of hospitalization 3 fold increased risk of heart problems 3 fold increased risk of blood clotting

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@zalaly

Ziyad Al-Aly, MD

2 years

The latest from our team in @NatureMedicine Does vaccination protect from #LongCovid ? Vaccines modestly reduce but do not eliminate risk of Long Covid @VAResearch @vahsrd @WUSTLmed @WUSTLnews @VREFSTL @Biostayan @BCBowe A thread 🧵

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Long COVID after breakthrough SARS-CoV-2 infection

Nature Medicine - A new analysis using the US Department of Veterans Affairs national healthcare databases demonstrates that Long COVID can occur after breakthrough SARS-CoV-2 infection; however,...

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@zalaly

Ziyad Al-Aly, MD

2 months

Long-term impact of covid is systemic and much more than flu 2 large cohorts from S Korea and Japan (>20 million people) Covid increased risk of autoimmune rheumatic diseases compared non-infected controls and compared to flu @MinSeoKim_MD

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Long-Term Autoimmune Inflammatory Rheumatic Outcomes of COVID-19: A Binational Cohort Study: Annals...

Background: Some data suggest a higher incidence of diagnosis of autoimmune inflammatory rheumatic diseases (AIRDs) among patients with a history of COVID-19 compared with uninfected patients....

www.acpjournals.org

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@zalaly

Ziyad Al-Aly, MD

4 months

The effort to address Long Covid must match the scale and urgency of the problem. #LongCovid

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Addressing Long COVID: Advancing Research and Improving Patient Care | The U.S. Senate Committee on...

The U.S. Senate Committee on Health, Education, Labor & Pensions

www.help.senate.gov

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@zalaly

Ziyad Al-Aly, MD

8 months

I told the Financial Times @FT that Long Covid results in a staggeringly high burden of disability & disease Our effort to address Long Covid must match its scale & urgency Treatment trials must be done at scale and urgently A piece by @hannahkuchler

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Wait goes on for effective long Covid treatments

Unlike the vaccine race, there is limited funding to treat a condition that is often debilitating

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@zalaly

Ziyad Al-Aly, MD

3 months

Here I chatted with @SarahNev from @FT for this piece The evidence suggests that Sars-Cov-2 infection leads to an increased risk of chronic disease Governments have not fully grasped the costly implications for healthcare systems and national economies

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Scientists grapple with long Covid puzzle as millions fall sick

Fears condition’s range of symptoms and link to chronic diseases will have lasting impact on health systems

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@zalaly

Ziyad Al-Aly, MD

2 months

I spoke to @NPR @Marketplace about the financial burden of protecting oneself from the hazards of COVID The government has a duty to protect its people Businesses also have a duty to ensure that their employees have a safe working environment @sam__fields …

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@zalaly

Ziyad Al-Aly, MD

2 months

The world must not turn its back on people with Long Covid. Long Covid is a significant global challenge that must decisively addressed. My statement on #LongCovidAwarenessDay #LongCovidAwarenessDay #ActOnLongCovid #LongCovid 👇👇

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@zalaly

Ziyad Al-Aly, MD

1 year

What does this mean for you? If you have Covid once, twice, three or more times, and even if you are vaccinated and boosted It is absolutely worth it to protect yourself from getting covid again

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Acute and postacute sequelae associated with SARS-CoV-2 reinfection

Nature Medicine - A new analysis using US Department of Veterans Affairs databases showed that reinfection is associated with increased risk of all-cause mortality, hospitalization and a wide range...

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@zalaly

Ziyad Al-Aly, MD

4 months

Thank you Chairman @SenSanders for your leadership We need a coordinated long-term approach to address the challenge of #LongCovid and chronic illnesses that are caused by acute infections

@SenSanders

Bernie Sanders

4 months

Thank you to the panelists and every person who tuned in to the long COVID hearing this week. This serious issue has not received the attention that it deserves from the medical community, from the media, and certainly not from Congress. It is past time that changes.

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@zalaly

Ziyad Al-Aly, MD

2 months

Covid-19 leaves its mark on the brain. My piece in @ConversationUS

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Mounting research shows that COVID-19 leaves its mark on the brain, including with significant...

Two new high-profile studies add to the increasingly worrisome picture of how even mild cases of COVID-19 can have detrimental effects on brain health.

theconversation.com

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@zalaly

Ziyad Al-Aly, MD

5 months

Long Covid is serious — best to avoid it Don’t trivialize reinfection — if you dodged the bullet the first time, you may not be so lucky the second time Thanks again to @BurnetInstitute for the honor of giving the 2023 Burnet Oration Summary with comments from @CrabbBrendan …

@BurnetInstitute

Burnet Institute

@BurnetInstitute

5 months

Data shows the risks of #COVID19 are higher than seasonal influenza because of the "extensive" organ involvement, @zalaly said during his keynote address at the Burnet Oration. "We found #LongCOVID can affect nearly every organ system," he said. Read more:

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@zalaly

Ziyad Al-Aly, MD

4 months

People really need to understand that reinfection is not without consequences. The evidence is clear. Yes. You can still get very sick with reinfection. Yes. You can get Long Covid with reinfection.

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Acute and postacute sequelae associated with SARS-CoV-2 reinfection

Nature Medicine - A new analysis using US Department of Veterans Affairs databases showed that reinfection is associated with increased risk of all-cause mortality, hospitalization and a wide range...

@taylorwhitney88

Taylor Whitney

@taylorwhitney88

4 months

@zalaly @EricTopol @latimes Dr Al-Aly…..people still aren’t getting your message. Posted on the last hour.

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@zalaly

Ziyad Al-Aly, MD

8 months

My interview with @statnews about covid reinfection and long covid #LongCovid #reinfection Thanks @cooney_liz !

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Does the risk of getting long Covid increase each time you get reinfected?

"It's very clear in our data that reinfection contributes additional risk of long Covid," says epidemiologist Ziyad Al-Aly.

www.statnews.com

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@zalaly

Ziyad Al-Aly, MD

5 months

📣 New from my team in @TheLancetInfDis Long-term outcomes of people hospitalized for COVID-19 vs seasonal influenza A 🧵

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Long-term outcomes following hospital admission for COVID-19 versus seasonal influenza: a cohort...

Although rates of death and adverse health outcomes following hospital admission for either seasonal influenza or COVID-19 are high, this comparative analysis shows that hospital admission for...

www.thelancet.com

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@zalaly

Ziyad Al-Aly, MD

5 months

Data from @StatCan_eng showing reinfection contributes additional risk of #LongCovid How many cases of #LongCovid could have been prevented if we took reinfection seriously?

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Acute and postacute sequelae associated with SARS-CoV-2 reinfection

Nature Medicine - A new analysis using US Department of Veterans Affairs databases showed that reinfection is associated with increased risk of all-cause mortality, hospitalization and a wide range...

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@zalaly

Ziyad Al-Aly, MD

1 year

The economic consequences of COVID-19 are huge Report from @TheEconomist forecasts 0.75% GDP loss in 2025 due to SARS-CoV-2 infections This equates to ~ $200 billion in US Reducing burden of Covid is not only the right public health approach, it is …

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Understanding the economic consequences of the covid-19 pandemic

impact.economist.com

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@zalaly

Ziyad Al-Aly, MD

3 months

This absolutely must change!!!! We developed vaccines at warp speed. We are doing trials for Long Covid at snail speed. This MUST change! #LongCovid

@SawyerBlatz

Sawyer 🏳️‍🌈

3 months

from warp speed to snail speed. h/t @zalaly ❤️

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@zalaly

Ziyad Al-Aly, MD

2 months

Covid leaves its mark on the brain! Reposting my piece in @ConversationUS on Covid and brain health #LongCovid

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Mounting research shows that COVID-19 leaves its mark on the brain, including with significant...

Two new high-profile studies add to the increasingly worrisome picture of how even mild cases of COVID-19 can have detrimental effects on brain health.

theconversation.com

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@zalaly

Ziyad Al-Aly, MD

8 months

COVID-19 hospitalizations are rising Please remember 2 things: 1) Reinfection is not benign; it can lead to health problems in both acute and post-acute #LongCovid phases of covid 2 infections are worse than 1 3 worse than 2

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Acute and postacute sequelae associated with SARS-CoV-2 reinfection

Nature Medicine - A new analysis using US Department of Veterans Affairs databases showed that reinfection is associated with increased risk of all-cause mortality, hospitalization and a wide range...

@zalaly

Ziyad Al-Aly, MD

1 year

Here is the latest from our team in @NatureMedicine Should you protect yourself from Covid-19 reinfection Yes! Reinfection is not benign; it is best to avoid it by @Bcbowe @Biostayan @zalaly A thread 🧵

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@zalaly

Ziyad Al-Aly, MD

1 year

Compared to noninfected controls, cumulative risks of repeat infection increased according to the number of infections Every reinfection contributes additional risk 3 infections worse than 2 2 infections worse than 1 1 infection worse than none

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@zalaly

Ziyad Al-Aly, MD

2 months

Impaired cognition after COVID Editorial in @NEJM by Cliff Rosen and myself With an illustration of mechanisms of cognitive dysfunction in #LongCovid 👇

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@zalaly

Ziyad Al-Aly, MD

4 months

Elevating my post on reinfection. Bottom line: Reinfection is not inconsequential; best to avoid it. More details in thread 🧵 below👇

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Acute and postacute sequelae associated with SARS-CoV-2 reinfection

Nature Medicine - A new analysis using US Department of Veterans Affairs databases showed that reinfection is associated with increased risk of all-cause mortality, hospitalization and a wide range...

@zalaly

Ziyad Al-Aly, MD

1 year

Here is the latest from our team in @NatureMedicine Should you protect yourself from Covid-19 reinfection Yes! Reinfection is not benign; it is best to avoid it by @Bcbowe @Biostayan @zalaly A thread 🧵

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@zalaly

Ziyad Al-Aly, MD

1 year

Reinfection also increased risk of Diabetes Fatigue Kidney problems Mental health disorders Musculoskeletal problems Neurologic disorders Lung problems

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@zalaly

Ziyad Al-Aly, MD

2 months

Senator Sanders @SenSanders announces that he will soon be introducing legislation to expand the federal effort to tackle the Long Covid crisis in the U.S. @SenSanders is the Chair of the U.S. Senate Committee on Health, Education, Labor & Pensions. #LongCovidAwarenessDay …

@SenSanders

Bernie Sanders

2 months

We cannot ignore the public health crisis that is Long COVID. On Long COVID Awareness Day, let us commit to doing everything we can to address this horrible condition. The U.S. government must do more to increase awareness and provide additional resources to develop treatments.

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@zalaly

Ziyad Al-Aly, MD

23 days

I talked to @CBCRadioCanada about the effects of Covid on brain health Thanks to host Bob McDonald and producer Amanda Buckiewicz Link to the news article and radio interview below

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COVID infections are causing drops in IQ and years of brain aging, studies suggest | CBC Radio

Researchers are trying to understand the profound effects of COVID-19 on the brain, looking at how it disrupts the blood-brain barrier, how it affects brain volume, and showing that even a mild case...

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@zalaly

Ziyad Al-Aly, MD

8 months

Long Covid research must be treated with urgency; bureaucratic delays are not acceptable The UK and the world need a coherent research strategy for #LongCovid and this must include speedy regulatory approval and long-term funding h/t @amibanerjee1

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UK’s Long Covid research under threat from regulator backlog, warn scientists

Researchers say funding for trials is running out because of delays at MHRA

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@zalaly

Ziyad Al-Aly, MD

1 year

How do we move forward? Reinfections are not benign and will continue to happen until We have vaccines that a. block transmission b. offer durable protection c. variant proof We also need prevention and treatment strategies for #LongCovid

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Acute and postacute sequelae associated with SARS-CoV-2 reinfection

Nature Medicine - A new analysis using US Department of Veterans Affairs databases showed that reinfection is associated with increased risk of all-cause mortality, hospitalization and a wide range...

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@zalaly

Ziyad Al-Aly, MD

2 months

Senator Bernie Sanders @SenSanders has just introduced a U.S. Resolution designating March 15, 2024, as "Long COVID Awareness Day" Thank you @SenSanders for your outstanding leadership!!!!

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@zalaly

Ziyad Al-Aly, MD

1 year

What are the broader implications? Reinfection will add to the pandemic's high and growing toll of death, disease, and disability Prevention of infection and reinfection with SARS-CoV-2 should continue to be the goal of public health policy

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Acute and postacute sequelae associated with SARS-CoV-2 reinfection

Nature Medicine - A new analysis using US Department of Veterans Affairs databases showed that reinfection is associated with increased risk of all-cause mortality, hospitalization and a wide range...

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@zalaly

Ziyad Al-Aly, MD

1 year

Importantly, Reinfection increased the risks of death, hospitalization and organ injury in the acute and post-acute phase and the elevated risks remained evident at 6 months after reinfection Reinfection increases the risk of acute and #LongCovid

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@zalaly

Ziyad Al-Aly, MD

1 year

In this study of 5.8 million people 41k with reinfection 444k with 1 infection (no reinfection) 5.3 million non-infected controls Compared to no reinfection, reinfection increased risk of death, hospitalization, and other adverse health outcomes

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@zalaly

Ziyad Al-Aly, MD

4 months

Just landed in DC to this great news!!! Please tune in tomorrow; hearing starts at 10 am ET. Link here:

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Addressing Long COVID: Advancing Research and Improving Patient Care | The U.S. Senate Committee on...

The U.S. Senate Committee on Health, Education, Labor & Pensions

www.help.senate.gov

@loscharlos

charlos

4 months

Downright incredible — no way this happens without these collective efforts. Thank you everybody who chose to use your limited energy to do something to help the #LongCovid community 🙏

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@zalaly

Ziyad Al-Aly, MD

2 months

b. The attribution of #LongCovid symptoms to psychological causes has no scientific support; it perpetuates stigma and disenfranchises patients from accessing the care they need. This belongs in the dustbin of history.

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Solving the puzzle of Long Covid

Long Covid provides an opportunity to understand how acute infections cause chronic disease

www.science.org

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@zalaly

Ziyad Al-Aly, MD

1 year

Covid-19 may lead to post-acute gastrointestinal (GI) disorders The latest from our team in @NatureComms by @evanjxu @Biostayan @zalaly A thread

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Long-term gastrointestinal outcomes of COVID-19

Nature Communications - SARS-CoV-2 infection can lead to varied post-acute symptoms in the lungs and other organs, including the gastrointestinal system. Here the authors estimate the risks and...

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@zalaly

Ziyad Al-Aly, MD

1 year

For the half a billion people who had #COVID19 once, the question of whether a second infection carries additional risks is important We show that reinfection increases risks of adverse outcomes in acute and post-acute phases of COVID-19

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Acute and postacute sequelae associated with SARS-CoV-2 reinfection

Nature Medicine - A new analysis using US Department of Veterans Affairs databases showed that reinfection is associated with increased risk of all-cause mortality, hospitalization and a wide range...

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@zalaly

Ziyad Al-Aly, MD

2 months

Thanks to @ScienceMagazine for highlighting this perspective by @EricTopol and myself on #LongCovidAwarenessDay We review key challenges in #LongCovid and discuss policy and research priorities

@ScienceMagazine

Science Magazine

@ScienceMagazine

2 months

A #SciencePerspective by @zalaly and @EricTopol identifies key issues that need to be prioritized in the study of #LongCovid . Learn more on #LongCovidAwarenessDay :

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Ziyad Al-Aly, MD

5 months

Prevention of Long Covid is not only good public health, it is also an economic imperative!

@kniggem

Michael Knigge

5 months

Now in English, the excellent and detailed article on Long Covid and what companies need to do to become mostly Covid-proof. “Companies have been ignoring the enormous long Covid risk for too long. Now they're paying for it – literally.”

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@zalaly

Ziyad Al-Aly, MD

3 months

The U.S. Government has an historic opportunity to address the care and research needs of #LongCovid The lives of millions of Americans now and the future depend on this!!! Thank you for your leadership Senator Sanders!!!! @BernieSanders

@SenSanders

Bernie Sanders

3 months

Last week, I led a hearing in the HELP Committee on long COVID. We must listen to the millions of Americans struggling with long COVID and give this issue the urgent attention it demands. If you missed it, tune in below.

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@zalaly

Ziyad Al-Aly, MD

2 months

More than 90% of cases occur in people who had mild SARS-CoV-2 infection

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Solving the puzzle of Long Covid

Long Covid provides an opportunity to understand how acute infections cause chronic disease

www.science.org

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@zalaly

Ziyad Al-Aly, MD

5 months

Delighted to give the 2023 Burnet Oration @BurnetInstitute Our response to #LongCovid must match its scale & urgency! National governments must address this challenge & prioritize findings treatments Failure is NOT an option!!!

@BurnetInstitute

Burnet Institute

@BurnetInstitute

5 months

We'd like to thank world-renowned COVID-19 researcher @zalaly for his engaging Burnet Oration on the worldwide burden and risks of #LongCOVID , and its impact on the human body. And @DrBronKing for sharing her personal story and advocating for clean air for all. #HealthEquity

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@zalaly

Ziyad Al-Aly, MD

5 months

Bottom line Covid is worse than flu Acute covid is worse than acute flu post-acute covid (long covid) is worse than post-acute flu

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Long-term outcomes following hospital admission for COVID-19 versus seasonal influenza: a cohort...

Although rates of death and adverse health outcomes following hospital admission for either seasonal influenza or COVID-19 are high, this comparative analysis shows that hospital admission for...

www.thelancet.com

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@zalaly

Ziyad Al-Aly, MD

1 year

Reinfection was associated with adverse health outcomes in unvaccinated those who had 1 vaccine shot those who had 2+ vaccine shots

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Ziyad Al-Aly, MD

1 year

Thanks to the amazing @sourwine for developing this press release (link below). A clear accounting of the findings. @WUSTLnews @WUSTLmed

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Repeat COVID-19 infections increase risk of organ failure, death | Washington University School of...

Researchers recommend masks, vaccines, vigilance to prevent reinfection

medicine.wustl.edu

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@zalaly

Ziyad Al-Aly, MD

1 year

Great news! @WhiteHouse is supporting a $5 billion program to: a. develop long-lasting monoclonal antibodies b. accelerate development of vaccines that produce mucosal immunity c. speed effort to develop variant-proof vaccines Thank you @AshishKJha46 for your leadership!…

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@zalaly

Ziyad Al-Aly, MD

2 months

Long Covid is a national crisis that must be decisively addressed. The time for action is now! Thank you Senator Kaine @timkaine for your leadership.

@SenTimKaine

Senator Tim Kaine

2 months

I’ve heard from many people about their experiences with Long COVID. On Long COVID Awareness Day, let’s recommit to educating people on Long COVID and keep working to pass my bipartisan Long COVID Support Act to accelerate Long COVID research and treatment.

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Ziyad Al-Aly, MD

2 months

On @NPR All Things Considered @julialmv and I talk to @WStoneReports about where we stand on #LongCovid We made progress; but people suffering from Long Covid need treatment We need larger & faster trials to identify effective treatment for Long Covid

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What Do We Understand About Long COVID? : Consider This from NPR

This week marks four years since the outbreak of Covid-19 was officially declared a pandemic. One of the most vexing legacies — one that science still hasn't solved — is long Covid. That's the...

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@zalaly

Ziyad Al-Aly, MD

5 months

Prioritize Long Covid research in the same way we prioritized vaccine development "we desperately need diagnostic tools...health worker training, & treatments to prevent and cure long COVID" by @majumdar_suman @CrabbBrendan Emma Pakula @MJLScoullar & me

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Could antivirals reduce your risk of long COVID? Where the research is up to on prevention and...

A promising collection of studies suggests taking antivirals such as Paxlovid during an infection could reduce the risk of developing long COVID.

theconversation.com

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@zalaly

Ziyad Al-Aly, MD

3 months

📢🚨🚨🚨New paper dropping Thursday. Embargoed until 2:00 PM ET Thursday February 22 . Interested journalists, email me. No DM please. #LongCovid

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@zalaly

Ziyad Al-Aly, MD

9 months

4/ In non-hospitalized, risks for coagulation disorders pulmonary disorders fatigue gastrointestinal disorders musculoskeletal disorders diabetes and others remained increased at 2 years - suggesting a longer lasting risk horizon for these organ systems

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Ziyad Al-Aly, MD

2 years

Now that we know that vaccines are not sufficient as a sole line of defense, we need to urgently develop and deploy additional layers of protection to reduce risk of Long Covid

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Long COVID after breakthrough SARS-CoV-2 infection

Nature Medicine - A new analysis using the US Department of Veterans Affairs national healthcare databases demonstrates that Long COVID can occur after breakthrough SARS-CoV-2 infection; however,...

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@zalaly

Ziyad Al-Aly, MD

1 year

Here is a terrific interview with @EricTopol in @FortuneMagazine by @cbarbermd “Right now, we are long on mechanisms and short on treatment. That’s the summary of everything." Grateful for his support of #LongCovid

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Leading COVID expert says not enough is being done to help long haulers: “People are desperate,...

Much remains unknown about long COVID, including the best ways to treat and prevent it.

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@zalaly

Ziyad Al-Aly, MD

4 months

Here is the full transcript of my verbal testimony. Thanks @SenSanders @SenBillCassidy @SenatorBraun @SenatorCollins @lisamurkowski @PattyMurray @SenMarkey @SenTimKaine @RogerMarshallMD @SenatorHassan @SenTinaSmith @SenatorRomney @SenatorHick @SenatorBaldwin

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@zalaly

Ziyad Al-Aly, MD

2 years

The latest from our team on the long-term cardiovascular consequences of Covid-19 in @NatureMedicine @VAResearch @vahsrd @WUSTLpubhealth @WUSTLmed @WUSTLnews @VREFSTL @NaturePortfolio @Biostayan @BCBowe A thread

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Long-term cardiovascular outcomes of COVID-19

Nature Medicine - Individuals with COVID-19 are at increased long-term risk for a wide range of cardiovascular disorders, even for individuals who were not hospitalized during the acute phase of...

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@zalaly

Ziyad Al-Aly, MD

2 months

Preventing infections and reinfections is the best way to prevent Long Covid and should remain the foundation of public health policy.

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Solving the puzzle of Long Covid

Long Covid provides an opportunity to understand how acute infections cause chronic disease

www.science.org

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@zalaly

Ziyad Al-Aly, MD

1 month

Impaired cognition in Long Covid. From @Rosen_Lab and myself in @NEJM The figure shows the various biologic mechanisms of cognitive impairment in #LongCovid

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Long Covid and Impaired Cognition — More Evidence and More Work to Do | NEJM

During the early stages of the Covid-19 pandemic, reports emerged that persons who had been infected with SARS-CoV-2 were having lingering health problems. Such long-term issues were collectively r...

@NEJM

NEJM

1 month

Editorial: Long Covid and Impaired Cognition — More Evidence and More Work to Do #Covid19

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@zalaly

Ziyad Al-Aly, MD

2 years

Not only COVID-19 is riskier than the flu. Even breakthrough COVID-19 is riskier than the flu

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Long COVID after breakthrough SARS-CoV-2 infection

Nature Medicine - A new analysis using the US Department of Veterans Affairs national healthcare databases demonstrates that Long COVID can occur after breakthrough SARS-CoV-2 infection; however,...

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@zalaly

Ziyad Al-Aly, MD

9 months

8/ A sizable chunk of Long Covid's high burden of disability and disease (25% non-hospitalized & 21% hospitalized) emerged anew in the second year after infection – pointing to a long-term risk horizon of SARS-CoV-2

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Ziyad Al-Aly, MD

1 month

I talked to @KitOConnell for this piece in the @TexasObserver about importance of cleaning the air to reduce risk of infection with airborne pathogens

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Clearing the Air: Long COVID Sufferers Call for a Healthier World

Even young, healthy Texans can suffer for years after COVID infections.

www.texasobserver.org

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@zalaly

Ziyad Al-Aly, MD

8 months

Re-upping my thread on our 2-year Long COVID study TLDR: Risks remain elevated for many health conditions even two years after infection Paper here: Thread:

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Postacute sequelae of COVID-19 at 2 years

Nature Medicine - Analysis of data from the US Department of Veterans Affairs showed that 2 years after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, risk for most...

@zalaly

Ziyad Al-Aly, MD

9 months

1/ 📣 New from my team in @NatureMedicine In a study of 6 million people, we examined risk trajectories of 80 components of Long Covid over 2 years post-infection 📌 Risks remained elevated for many Long Covid conditions even 2 years infection A 🧵

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Ziyad Al-Aly, MD

9 months

9/ 🤔 What does this mean? This illustrates the long and arduous journey of dealing with the long-term health consequences of the virus COVID-19 still generates substantial additional risks of health loss even in the second year after infection

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Postacute sequelae of COVID-19 at 2 years

Nature Medicine - Analysis of data from the US Department of Veterans Affairs showed that 2 years after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, risk for most...

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@zalaly

Ziyad Al-Aly, MD

2 months

This includes ➡️masking — especially in high risk places ➡️improved air quality through filtration and ventilation ➡️Updating building codes to require mitigation against airborne pathogens

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Solving the puzzle of Long Covid

Long Covid provides an opportunity to understand how acute infections cause chronic disease

www.science.org

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@zalaly

Ziyad Al-Aly, MD

1 year

The latest from our team in @TheLancetEndo We know that SARS-CoV-2 infection may lead to metabolic disturbances including increased risk of diabetes in #LongCovid But does it also increase risk of high cholesterol? by @evanjxu @Biostayan @zalaly

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Risks and burdens of incident dyslipidaemia in long COVID: a cohort study

Our findings suggest increased risks and 1-year burdens of incident dyslipidaemia and incident lipid-lowering medications use in the post-acute phase of COVID-19 infection. Post-acute care for those...

www.thelancet.com

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@zalaly

Ziyad Al-Aly, MD

4 months

3. Both covid and flu cause more health loss in the long-term than what is evident around the time of the infection Trivializing these illnesses as inconsequential ignores the large burden of health loss that occurs in the post-acute/chronic/long phase

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Long-term outcomes following hospital admission for COVID-19 versus seasonal influenza: a cohort...

Although rates of death and adverse health outcomes following hospital admission for either seasonal influenza or COVID-19 are high, this comparative analysis shows that hospital admission for...

www.thelancet.com

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@zalaly

Ziyad Al-Aly, MD

9 months

3/ In people who were not hospitalized during the acute phase of COVID (the majority) risk of death remained elevated up to 6 months risk of hospitalization remained elevated up to 19 months risks remained elevated for 31% of sequelae during the 2-year

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Ziyad Al-Aly, MD

2 years

Even mild COVID-19 can lead to serious neurologic consequences Risks developing these long-term consequences were evident even among people who were not hospitalized during the acute phase of COVID-19 infection

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@zalaly

Ziyad Al-Aly, MD

3 months

I talked to @TheWorld about the @CDCgov plan to drop the five-day covid isolation guidelines We also talked about #LongCovid in kids and more Link below

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@zalaly

Ziyad Al-Aly, MD

2 years

In this study of more than 13 million people Long Covid after breakthrough infection (vaccinated people who subsequently got SARS-CoV-2 infection) is indistinguishable in terms of clinical features from Long Covid in unvaccinated people

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Long COVID after breakthrough SARS-CoV-2 infection

Nature Medicine - A new analysis using the US Department of Veterans Affairs national healthcare databases demonstrates that Long COVID can occur after breakthrough SARS-CoV-2 infection; however,...

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@zalaly

Ziyad Al-Aly, MD

2 years

Knowing that infection seems almost unavoidable in the current environment and knowing that the risk of Long Covid in vaccinated people is not small means that many will be left with chronic and potentially disabling disease that has no treatment

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Long COVID after breakthrough SARS-CoV-2 infection

Nature Medicine - A new analysis using the US Department of Veterans Affairs national healthcare databases demonstrates that Long COVID can occur after breakthrough SARS-CoV-2 infection; however,...

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@zalaly

Ziyad Al-Aly, MD

2 years

Can Covid-19 lead to diabetes? New from our team on risk and burden of diabetes in Long Covid at 1 year In @TheLancetEndo @VAResearch @vahsrd @WUSTLpubhealth @WUSTLmed @WUSTLnews @VREFSTL @Biostayan A thread 🧵

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Risks and burdens of incident diabetes in long COVID: a cohort study

In the post-acute phase, we report increased risks and 12-month burdens of incident diabetes and antihyperglycaemic use in people with COVID-19 compared with a contemporary control group of people...

www.thelancet.com

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@zalaly

Ziyad Al-Aly, MD

2 months

We need to understand the social impacts of #LongCovid Here is a symposium organized by @DALupton addressing exactly that question 18 presentations across two sessions to accommodate different time zones Free registration. Link 👇

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The Social Impacts of Long COVID: an online symposium

Join us for this online seminar examining the social impacts of long COVID across geographical locations and socioeconomic contexts.

www.eventbrite.com.au

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@zalaly

Ziyad Al-Aly, MD

5 months

Covid had higher risk of death, healthcare utilization and sequelae in most organ systems than flu This was evident in pre-delta, delta, and omicron; and also evident in vaccinated and unvaccinated individuals.

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Ziyad Al-Aly, MD

2 years

I talked to @NPR "However you slice it, there was never an instance where COVID-19 was milder than the flu" major distinction between #covid and #flu is #LongCovid which can manifest even in mild cases Most #LongCovid in the world is due to mild cases

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Scientists debate how lethal COVID is. Some say it's now less risky than flu

They argue the threat posed by COVID has lessened because of preexisting immunity and access to treatment. Plus, some deaths may be incorrectly blamed on COVID. Others caution it's too soon to tell.

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@zalaly

Ziyad Al-Aly, MD

9 months

12/ We also need an urgent, coordinated approach that matches the scale and gravity of long COVID to find treatments as soon as possible

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Postacute sequelae of COVID-19 at 2 years

Nature Medicine - Analysis of data from the US Department of Veterans Affairs showed that 2 years after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, risk for most...

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@zalaly

Ziyad Al-Aly, MD

5 months

Risks were higher in Covid for all organ systems except for the pulmonary system which was higher in flu Covid is more multisystemic than flu Flu is more respiratory than Covid

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