Teresa Rayon @t_rayon Twitter profile

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Teresa Rayon

1 year

A short piece about molecular mechanisms for the control of tempo in cells & types of heterochronies 🐭⌛️👤⏳

Cell time: How cells control developmental timetables

An overview on the molecular and metabolic mechanisms behind individual cell differences in developmental timing in the segmentation clock and the central nervous system.

www.science.org

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Teresa Rayon

@t_rayon

4 years

Our work #aboutime "Species-specific pace of development is associated with differences in protein stability" is now published . What determines the pace of embryonic development?

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Teresa Rayon

@t_rayon

2 years

I’couldn’t be happier with the news💃🏼🎉👩‍🔬 The grant will fund our work to understand the molecular & metabolic mechanisms that control developmental timing #TempoReg Thanks to all my network for the support. ..and please do reach out if you’d want to join the team! 🐭⌛️ 👤 ⏳

European Research Council (ERC)

@ERC_Research

2 years

More than 4,000 ambitious young researchers entered the 2021 competition for ERC Starting Grants. 🎊 Congratulations to the 397 who were selected for 🇪🇺 #EUfunded support this time! Maybe you know one? List ➡️ #ECR #PhDLife #PhDChat #AcademicChatter

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Teresa Rayon

@t_rayon

3 years

An ex vivo model for mouse peri-implantation by the Hiiragi lab. Amazed to see the morphological changes in the epiblast from pre- to post-implantation live. A movie is worth a thousand words.

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Teresa Rayon

@t_rayon

3 years

Very happy to join @BabrahamInst together with all these amazing scientists 👩‍🔬soon to be.. #NewPI

Babraham Institute

@BabrahamInst

3 years

The Institute is also pleased to announce the appointments of Dr Teresa Rayon @t_rayon of @TheCrick , Dr Sophie @trefely of @Penn and Dr Philipp Voigt of @WTcell They will be joining us over the coming months. Read more about their research aims here:

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Teresa Rayon

@t_rayon

2 years

First day @BabrahamInst today. I know that all wet labs look more or less the same, but this will be the bench for our next #devbio experiments. …and there were two pigeon holes for the Rayonlab!! #NewPI

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Teresa Rayon

@t_rayon

3 years

Looking for team members to join my lab @BabrahamInst . 📢We're looking for an experienced researcher. 📢We're recruiting a PhD student through the Babraham PhD programme. Please RT 👏👏

Rayon lab

Comparative Stem Cell Dynamics

rayonlab.org

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Teresa Rayon

@t_rayon

5 months

🚨we’re looking for a Postdoc (2-years initially) to develop a project on dev. tempo in mouse embryos 🐭 ⌛️ 📩 drop an email for further info Link: Closes Jan 31st 🔁Please RT

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Teresa Rayon

@t_rayon

3 years

Our spatio-temporal single-cell atlas of the human developing spinal cord is online. We provide an overall description of the data and comparisons with mouse to identify human-specific features. Samples were obtained pre-covid from the amazing MRC-WT HDBR.

Single cell transcriptome profiling of the human developing spinal cord reveals a conserved genetic...

The spinal cord receives input from peripheral sensory neurons and controls motor output by regulating muscle innervating motor neurons. These functions are carried out by neural circuits comprising...

www.biorxiv.org

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Teresa Rayon

@t_rayon

4 years

Back to the bench 93 days later. Here’s a time lapse of me setting up an immuno on sections.👩🏼‍🔬🔬

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Teresa Rayon

@t_rayon

3 years

Good news everyone! Our transcriptomic atlas of the human developing spinal cord is online now in @Dev_journal . Really proud of the work that @rorymaizels , Christopher Barrington, @briscoejames & I have put together. 🧵

Single-cell transcriptome profiling of the human developing spinal cord reveals a conserved genetic...

Summary: Single-cell transcriptome analysis of the neural tube of human embryos from gestational weeks 4-7 provides insight into the molecular complexity and cellular diversity of the developing...

journals.biologists.com

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Teresa Rayon

@t_rayon

2 years

📢📢Looking for a #PhD student for the lab @BabrahamInst 🐭⌛️👤⏳ Researchers: Please share the info with grad students that you think may be interested Grad students: Check if this project interests you & get in touch!

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Teresa Rayon

@t_rayon

4 months

🚨we’re looking for a Postdoc (2-years initially) 🐭⌛️ 📩 drop an email for further info Closes Jan 31st

Babraham Institute

@BabrahamInst

4 months

VACANCY: Postdoctoral Research Scientist Looking for a new role this year? Check out this opportunity to contribute to our understanding of tempo in mammalian development ⏰

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Teresa Rayon

@t_rayon

4 years

First 2020 post to share our preprint on the temporal control of motor neuron development 🥳. The pace is ~2.5x slower in humans versus mouse, and speed differences correspond with differences in protein stability. Fun to work with all authors!! #aboutime

Species-specific developmental timing is associated with global differences in protein stability in...

What determines the pace of embryonic development? Although many molecular mechanisms controlling developmental processes are evolutionarily conserved, the speed at which these operate can vary...

www.biorxiv.org

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Teresa Rayon

@t_rayon

3 months

The lab has turned 2 🎂! Thanks to all lab members, colleagues & everyone @BabrahamInst for helping us get on with our science. ..I'm excited for whatever achievements come on year 3 *Science images credit of Jo, @azziChiA & Ellie.

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Teresa Rayon

@t_rayon

2 years

Delighted to have this team at the Rayon lab. Shota, @azziChiA and I with Eleonore Ocana, the lab’s first brand new PhD student, in our traditional welcoming lunch @ The George. Can’t wait for all our future experiments and discoveries! 🐭⌛️👤⏳

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Teresa Rayon

@t_rayon

10 months

Research Assistant position (up to 3-years) 💡Develop a project on dev. tempo with stem cells. Use CRISPR-based manipulations, flow cytometry, mass spec and more ✍️ Lab management 🧪 Train lab members apply OR info: Closes Sept 8 *Please RT* @lsn_jobs

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Teresa Rayon

@t_rayon

2 years

Moving out. Bittersweet feelings as this unrepeatable period @briscoejames ’ lab at NIMR and TheCrick comes to an end. A 6-year journey supported by the best. Now onto the next staircases. *Catch ya later London

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Teresa Rayon

@t_rayon

2 years

All the hard work put in to be awarded an #ERCStG , and we are now in the hands of a political decision. ☹️

European Research Council (ERC)

@ERC_Research

2 years

@fetzert @Federomei1 @XJaravel @a_m_elsner Indeed, the ERC has sent letters to successful UK-based applicants for Starting, Consolidator and Advanced Grants giving them 2 month to decide if they move to an eligible host institution or give up the grant. We'll be ready to extend this time in exceptional, justified cases.

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Teresa Rayon

@t_rayon

3 years

Slower protein turnover correlates with a longer lifespan and reduced energy consumption. The final version is out 📢🤩

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Teresa Rayon

@t_rayon

3 years

ICYMI - A review where we discuss how the comparison across species in biological contexts may help us decipher the timekeeping mechanisms in development & homeostasis. Hope you like it! #aboutime 🐭⌛️👤⏳

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Teresa Rayon

@t_rayon

3 years

Really excited about this new role! Thanks to the SEBD for counting on me, and excited to start with two other great #devbio advocates committed to public engagement 🍾

SEBD

@SEBiolDev

3 years

After the annual assembly this year at #SEBD2020 , #SEBD is happy to announce the incorporation of 3 new members of the board: Sofia J. Araújo @sofiajaraujo from @GeneticsUB @BiologiaUB , Juanjo Sanz-Ezquerro @jjsanzezquerro @CNB_CSIC and Teresa Rayon @t_rayon @TheCrick Welcome!

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Teresa Rayon

@t_rayon

2 years

Three new preprints provide single cell transcriptomic data of the human developing spinal cord. Different stages, approaches and new hypothesis in them. What next? What’s missing? These papers open the path towards experimental validation of hypothesis👩‍🔬 Key findings👇🏻

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Teresa Rayon

@t_rayon

4 years

1 dog year ≠ 7 human years. An methylation signature on developmental genes that aligns aging in dogs, humans, and mice.

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Teresa Rayon

@t_rayon

3 years

“As successful as you are, were, or hope to be in your life and work, you are not going to find true happiness on the hedonic treadmill of your professional life”

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Teresa Rayon

@t_rayon

3 months

Work from @VallierLab , Irina Mohorianu @SCICambridge and our lab @BabrahamInst on the in vitro generation of human amnion cells from primed hPSCs. Glad to see it out 🍾

Human surface ectoderm and amniotic ectoderm are sequentially specified according to cellular...

The in vitro model reveals that human nonneural ectoderm develops into embryonic and extraembryonic tissues based on cellular density.

www.science.org

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Teresa Rayon

@t_rayon

2 years

One month in @BabrahamInst . Happy #InternationalWomensDay to everyone. 👩‍🔬🎂

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Teresa Rayon

@t_rayon

10 months

Disadvantages for non-native English speakers in scientific research. *propose a ‘concerted effort, at institutional level, to minimise the disadvantages for non-native English speakers’ * survivorship bias explains disappearing disadvantages

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Teresa Rayon

@t_rayon

6 months

Comprehensive and beautiful review on timing mechanisms of human neuronal maturation by @JenelleLWallace @brainevodevo . A must read for my lab!

Human neuronal maturation comes of age: cellular mechanisms and species differences

Nature Reviews Neuroscience - Human cortical neurons undergo a protracted period of postmitotic maturation compared with those of other species. Wallace and Pollen review the cell-intrinsic and...

www.nature.com

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Teresa Rayon

@t_rayon

5 years

Single cell transcriptomics of the developing neural tube. Our work with Julien, Andreas, @briscoejames and co is ready for all to read! We identify with our atlas a temporal programme for neurogenesis common in all domains. Read it in full here:

Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the...

The coordinated spatial and temporal regulation of gene expression in the vertebrate neural tube determines the identity of neural progenitors and the function and physiology of the neurons they...

www.biorxiv.org

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Teresa Rayon

@t_rayon

1 year

An important message for #WomenInScience day: Diversify senior positions and improve quantitative metrics to ameliorate the academic system. ‘ignorance is found at every step of the process and in every scientific institution’

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Teresa Rayon

@t_rayon

2 years

A mouse embryo made into a puzzle. Once used at the #cricklates and rescued by @enabel_sp #SciArt * in case you wondered.. SOX1-CreERT2 YFP clones + OLIG2 staining in the neural tube (Tamoxifen induction @E8 .5) #unfinishedproject

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Teresa Rayon

@t_rayon

4 years

ESCs, EpiSC, EpiLCs, Rosette-like ESCs.. defining criteria to evaluate all these pluripotency "flavors" might be as important as for totipotent cells. and

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Teresa Rayon

@t_rayon

3 months

An effort to summarize & offer perspective to the signalling implications of glucose metabolism in development from latest preprints. Hopefully enjoyable for authors & community. *A great excuse to collaborate with my former colleague @AshleyLibby12 ⚡️ 💙preprints 👇🏻👇🏻👇🏻

Development

@Dev_journal

3 months

In preprints: puzzling together roles for glucose metabolism during gastrulation Ashley Libby @AshleyLibby12 and Teresa Rayon @t_rayon discuss four recent #preprints on glucose metabolism as a possible signalling axis in the control of gastrulation:

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Teresa Rayon

@t_rayon

1 year

Thanks @ScienceCluster & @nigrelex for the cool memento of the talk!

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Teresa Rayon

@t_rayon

2 years

#NewPI question. Can people recommend Lab-inventory management software? *Free *Web-based *Easy import/export database @Quartzy seems a good option, any opinions for/against? Thanks! @NewPICellDev @SEBiolDev @YEN_community @the_Node @ASAPbio_

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Teresa Rayon

@t_rayon

5 years

@TheCrick dev bio community at #EDBC2019 🇬🇧 🇪🇺

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Teresa Rayon

@t_rayon

7 months

Interested in understanding proteostasis mechanisms and how they fail in motor neuron disease for your PhD? @Ian_J_McGough and I have partnered with @AxolBio to combine our expertise and address this question. info: Apply if keen!

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Teresa Rayon

@t_rayon

5 years

For those planning the trip to #EDBC2019 : buy an early flight to Alicante!! Come and discuss with @sofiajaraujo editors from @Co_Biologists , @PLOSBiology , @Dev_Bio_Journal , @fcasfer and @JesusVicSan about *preprints & scientific publishing*

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Teresa Rayon

@t_rayon

3 years

Why SOX2 levels matter. Low-affinity SOX2 sites are co-occupied by T/Bra and CDX in NMPs (low SOX2). Congratulations to Robert Blassberg and co. Great to see it out! 🍾🎊🥂 *Deletion of SOX2 binding sites in the CDX2 intronic enhancer reduces its activity in NMP conditions😍

James Briscoe

@briscoejames

3 years

Our latest: How does one signal produce different responses in different cell types? WNT signaling maintains ES cells, posteriors epiblast, induces mesoderm SOX2 levels determines WNT response by recruiting TCF/b-catenin to different genomic targets

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Teresa Rayon

@t_rayon

2 years

Just filled the feedback form for #EMBOdevTempo . I'm amazed about how much interest the topic has raised. Thanks @EbisuyaMiki @twobluechickens @briscoejames @VanderhaeghenP2 for organising a tailored workshop & to all speakers for openly sharing unpublished data. 🤞 to the next!

Dr. Lionel Christiaen (he/him/his)

@lionlchristiaen

2 years

Getting to the core questions with Teresa Rayon whose work spearheaded our understanding of DevTempo #EMBOdevtempo

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Teresa Rayon

@t_rayon

1 year

Ditto

Maria Christophorou

@MAChristoLab

1 year

With my amazing ⁦ @BabrahamInst ⁩ Epigenetics colleagues ⁦ @t_rayon ⁩ & ⁦ @irene_zorzan ⁩, representing at #StemCellNiche2023 . A fantastic meeting with very enjoyable science, incredible hospitality and visit to the Copenhagen Opera to boot! 🤩

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Teresa Rayon

@t_rayon

4 years

A changing waddingtonian landscape in vivo versus in vitro? Conserved developmental trajectories in vitro across species can vary in vivo due to extraembryonic signals or morphological constrains (geometry). Interesting proposal to be tested in space and time

Trivedi Lab

@LabTrivedi

4 years

Our latest preprint by Anlas et al @EMBLBarcelona @the_prbb describes how in vitro/ex vivo embryo-like systems from different species hint towards an evolutionarily conserved developmental mode of primary (AP and OA) body axis formation.

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Teresa Rayon

@t_rayon

6 months

Still time to apply. Check it out 👇🏻👇🏻

Babraham Institute

@BabrahamInst

6 months

FUNDED PHD OPPORTUNITY: ‘Developmental timing in mouse, human and chimeric stem cell models’ with Dr Teresa Rayon Apply by 1st December Find out more: #PhD #PhDVacancies #PhDStudents #PhDProjects @t_rayon

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Teresa Rayon

@t_rayon

5 years

Adding some EU to my cells at Brexi times

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Teresa Rayon

@t_rayon

4 years

et voilà

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Teresa Rayon

@t_rayon

1 year

Happy holidays, and may all your experiments come true!

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Teresa Rayon

@t_rayon

6 months

Effect of temperature stress in developing 🐠 *changes in cell proportions & ⬆️ tempo asynchrony *independent of heat shock response *proteostasis burden in the notochord *opposite to translation inhibition Beautiful work @mwdorr er al! 🎉⚡️

Proteostasis governs differential temperature sensitivity across embryonic cell types

Embryo-wide profiling of transcription, timing, and cell composition in zebrafish reveals processes that limit developmental robustness under increasing temperatures.

www.cell.com

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Teresa Rayon

@t_rayon

2 years

Neat work on human blastoids!! it seems that stem cell models are getting closer to human blastocysts each time. The latest version provides an exhaustive characterization of their model and includes a *very useful* comparison across all the blastoid publications 👇👇👇

Alok Javali

@alok_javali

2 years

Extremely excited to share our recently published paper in @Nature where we report formation of a faithful in vitro model of human blastocyst. @NRivron lab @IMBA_Vienna A long tweetorial alert! [1/29]

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Teresa Rayon

@t_rayon

11 months

Human stem-cell based embryo models, specially those monitoring implantation and peri-gastrulation, offer new scientific prospects and societal concerns. Scientists at @Cam_Repro are driving initiatives to develop governance framework. 👇🏻👇🏻👇🏻

Cambridge University

@Cambridge_Uni

11 months

Stem cell-based embryo models could help our understanding of the problems that can affect early pregnancies. But their regulation is a grey area. That's why @Cam_Repro has launched a project to develop a governance framework for this research in the UK 👇

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Teresa Rayon

@t_rayon

1 year

Thanks for the opportunity, it is a great initiative promoting #preprints . I used it to reach out and meet @Jellevda - insightful & fun interaction🔝 and also..the very first written output from the lab! 🐭⌛️👤⏳

Development

@Dev_journal

1 year

In preprints: releasing the brakes on neuronal maturation @t_rayon and @Jellevda discuss developmental timing in the CNS, highlighting three preprints that describe different mechanisms that determine the timing of cortical neuron maturation.

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Teresa Rayon

@t_rayon

5 years

Really proud to see our paper amongst those on the special issue: loads of scRNAseq beyond cataloguing

Development

@Dev_journal

5 years

Our Special Issue, Development at the Single Cell Level, is now complete! The cover features the winning entry from our #singlecell cover competition and depicts two iconic developmental biology models: chick and zebrafish.

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Teresa Rayon

@t_rayon

2 years

So sad I’ll miss #ISDB2021 .Lots of great talks & @SEBiolDev assembly meeting. For the lucky ones that manage to be there… please tweet and keep us posted :)

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Teresa Rayon

@t_rayon

1 year

I’m extremely excited about this conference!! Thanks for the invitation 🍾 Please join us: small size conference, beautiful city & loads of interesting talks on genomics and evolution #EMBOevoAnimalGenomes

Darío G. Lupiáñez

@Dariloops

1 year

Still open spots for the @EMBO workshop "The evolution of animal genomes"🐷🐸🐭 A fantastic speaker line up and many opportunities for young researchers to present their work 🤓 Child care and travel grants available 👇

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Teresa Rayon

@t_rayon

6 years

Notch role during pre-implantation development strikes back.Really happy to see our work published as a preprint on #OAWeek :)

Sergio Menchero

@sermenchero

6 years

Glad to see our latest work on Notch activity during preimplantation development as the first preprint from the lab #OAWeek @MigManzanares @t_rayon @JGSdA @MajoAndreu

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Teresa Rayon

@t_rayon

2 years

THREE amino acid substitutions in KIF18a and KNL1 cause a prolonged metaphase and fewer chromosome inheritance errors specifically in neural apical progenitors of modern humans than in archaic humans and apes. Beautiful work and congrats to all authors 🎉

MPI-CBG Dresden

@mpicbg

2 years

Taking your time makes a difference – Brain development differs between Neanderthals and modern humans: latest study by the lab of Wieland Huttner @mpicbg , first author @FeMoraBermudez , and @SvantePaabo @MPI_EVA_Leipzig in @ScienceAdvances .

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Teresa Rayon

@t_rayon

5 years

Identification of endogenous cell competition in the pre-implantation epiblast by the Hippo pathway. Great preprint from Hiroshi Sasaki's lab. Read our joint @preLights with @SarahBowling15 :

Epiblast formation by Tead-Yap-dependent expression of pluripotency factors and competitive...

Differentiate or die! A new role for cell competition and Hippo signalling in the early mouse embryo

prelights.biologists.com

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Teresa Rayon

@t_rayon

2 years

Time to take a moment to think and remember what 2021 has been like in the lab, a very challenging year in the midst of a pandemic and missing in person interactions with mentors, family and friends.

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Teresa Rayon

@t_rayon

3 years

As the end of this bizarre 2020 approaches, it feels is time to reflect on my scientific year. Most of the successes come from the support and interaction with great people & friends around me in the @briscoejames lab and beyond. Thanks :) Can't wait for 2021. 1/10

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Teresa Rayon

@t_rayon

3 years

A day to celebrate #WomenInScience & the scientific community 👩‍🔬🧫👨‍🔬🧬🧑‍🔬🧪

SEBD

@SEBiolDev

3 years

Esta semana la @SEBiolDev está visibilizando a sus socias #SEBD11F por el Día Internacional de la Mujer y la Niña en la Ciencia #11F @11defebreroES #DiaDeLaMujerYLaNinaEnLaCiencia #WomenInScience Feliz día a todas!

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Teresa Rayon

@t_rayon

4 years

New @preLights covering @EPosfai @vincentpasque @fredrik_lanner and Janet Rossant's lab latest #preprint Incredible quest and great work to define totipotency in stem cells and set standards. Check the summary table and the author's response! ⤵️

Defining totipotency using criteria of increasing stringency - preLights

Capturing totipotency in the dish: gold standards for analyzing embryonic stem cell contributions combined with molecular analyses.

prelights.biologists.com

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Teresa Rayon

@t_rayon

4 years

Live long and proteostasis! My latest @preLights about the role of protein turnover in long-lived organisms like the bowhead whale and the naked mole-rat. Thanks to Kyle Swovick from Sina Ghaemmaghami's lab @UofR for his response :)

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Teresa Rayon

@t_rayon

9 months

We will close the advert shortly. If interested, apply NOW and do not leave it until the very last minute!

Teresa Rayon

@t_rayon

10 months

Research Assistant position (up to 3-years) 💡Develop a project on dev. tempo with stem cells. Use CRISPR-based manipulations, flow cytometry, mass spec and more ✍️ Lab management 🧪 Train lab members apply OR info: Closes Sept 8 *Please RT* @lsn_jobs

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Teresa Rayon

@t_rayon

2 years

Synthetic embryos *Develop AP & DV axis 😱 *Without the need to go through implantation 🤯 *Where there any other consistent morphologies in the remaining ~99% embryoids? or only one morphology can be attained?

Post-gastrulation synthetic embryos generated ex utero from mouse naive ESCs

Post-gastrulation stages of development with organ progenitors and complex extra-embryonic compartments are achieved ex utero entirely from assembled naive mouse embryonic stem cells.

www.cell.com

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Teresa Rayon

@t_rayon

3 years

Always pleased to discuss about our work and why we publish #preprints .

preLights

@preLights

3 years

We caught up with @t_rayon , a postdoc in @briscoejames 's lab, for our preprints by preLighters series. Find out about more about Teresa and her new work here:

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Teresa Rayon

@t_rayon

4 years

A revised model of early cardiac development using lineage tracing and single-cell transcriptomics in mouse embryos (with incredibly pretty confocal images). Congratulations to all authors 👯‍♀️💃

James Briscoe

@briscoejames

4 years

New preprint: @KenzoIvanovitch combined genetic lineage tracing & single cell transcriptomics to trace spatiotemporal & molecular origin of heart Distinct molecular signatures of primitive streak cells contributing to ventricles, outflow tract & atrium

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Teresa Rayon

@t_rayon

4 years

My top 3 applications for CRISPR/Cas in #devbio : 1. Simultaneous tagging/deletion of multiple genes 2. Works in less established model organisms 3. Simple editing/deletion of regulatory (non-coding) elements

the Node

@the_Node

4 years

New on the Node: The 2020 Nobel Prize in Chemistry: CRISPR/Cas technology Hear from @Dev_journal Editors how CRISPR has impacted their research. We'd also love to hear from you so leave your thoughts and stories in the comments!

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Teresa Rayon

@t_rayon

1 year

Lay summary with comments from @suzanahh about the latest beautiful work @VanderhaeghenP2 🧠💙⏳

Mitochondrial Metabolism Dictates Neurons’ Growth Rate

Altering the rate of respiration in mitochondria changes how fast neurons grow, making mouse neurons grow more like human ones and vice versa, a study finds.

www.the-scientist.com

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Teresa Rayon

@t_rayon

2 years

“Failure to secure UK association to Horizon Europe would be a lose-lose for health, wealth and wellbeing and would do a disservice to future generations in Europe and beyond” …Still waiting for it to be resolved…

James Briscoe

@briscoejames

2 years

The UK's association with @HorizonEU in mainstream media It's time to end the uncertainty. Both sides gain by association & it would demonstrate compromise is possible BBC News - Universities warn of EU-UK research scheme 'close to precipice'

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@t_rayon

8 months

UK is back in the game!! 👏🏻🔬👩‍🔬 It’s incredible that the negotiations have taken this long (3 years), and I hope ERC stats for UK pick back up.

UK Research and Innovation

@UKRI_News

8 months

"Today's agreement on UK association to Horizon Europe is brilliant news" - @UKRI_CEO More on the deal announced by the government this morning:

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Teresa Rayon

@t_rayon

4 years

Thanks @poljiology for the flip book! No need to see movies of the segmentation clock anymore. #RSBioDynamics

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Teresa Rayon

@t_rayon

4 years

Always keep promoting and supporting each other 💜 #8M2020 #InternationalWomensDay 💜

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Teresa Rayon

@t_rayon

4 years

Really excited to give a virtual talk #Aboutime back-to-back with @EbisuyaMiki tomorrow at @MPI_MolGen 💃

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Teresa Rayon

@t_rayon

4 years

Resumen de nuestro trabajo explicado en castellano 🐭⌛️🚻⏳

SINC

@agencia_sinc

4 years

Los embriones de humanos y ratones no crecen al mismo ritmo debido a la tasa de producción y eliminación de las proteínas celulares, más rápidas en el caso de las células de ratón @ComunidadCeru @TheCrick

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Teresa Rayon

@t_rayon

4 years

Resumen del año de #EnFaseExperimental . Almudena Ramiro, @NietoAngela y @FJCarmonas en el top 3 de escuchas. Gracias a @Laurawendy @2piruben @BertaVerd y Cristina por su trabajo 🎉

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Teresa Rayon

@t_rayon

1 year

Starting the second ordering book @BabrahamInst . Yes, it is a carbon copy -old fashioned book that grows on you…

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Teresa Rayon

@t_rayon

3 years

Deadline this Sunday 🐭⌛️👤⏳

Babraham Institute

@BabrahamInst

3 years

VACANCY: @t_rayon is recruiting a postdoc to drive efforts towards establishing a causal link of protein turnover on the rate of development Deadline: 14th November Full job spec and apply here ➡️ #PostdocJobs #ScienceJobs #Epigenetics #DevBio

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Teresa Rayon

@t_rayon

4 months

Few days left to apply!

Teresa Rayon

@t_rayon

4 months

🚨we’re looking for a Postdoc (2-years initially) 🐭⌛️ 📩 drop an email for further info Closes Jan 31st

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Teresa Rayon

@t_rayon

3 years

@briscoejames and I wrote a review where we discuss how the comparison across species in biological contexts may help us decipher the timekeeping mechanisms in development & homeostasis. Hope you like it! #aboutime 🐭⌛️👤⏳

Cross-species comparisons and in vitro models to study tempo in development and homeostasis |...

Time is inherent to biological processes. It determines the order of events and the speed at which they take place. However, we still need to refine approaches to measure the course of time in...

royalsocietypublishing.org

Rubén Pérez-Carrasco

@2piruben

3 years

It's time's time! Our special issue addressing current questions to dynamics in biology is out. Thanks to all the contributors, the @royalsociety , and to my partner in crime @BertaVerd

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Teresa Rayon

@t_rayon

3 years

No huge changes in preprints pre- and post-publication (peer-reviewed) means we can use & disseminate preprints with the same trust as we do with published papers. Personal critical reading is a must. *Congrats all authors for this very interesting analysis 🧐 👏🏻👏🏻👏🏻

Jonny Coates (jacoates.bsky.social)

@JACoates

3 years

We found that over 70% of published preprints that we analysed were classified with “no change” or only superficial rearrangements to panels and tables upon publication. Although, ~20% of articles had “significant content” added or removed from the figures

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Teresa Rayon

@t_rayon

4 years

Excitingly, our findings are complementary to those on the species-specific oscillation periods of human and mouse segmentation clocks by @EbisuyaMiki . Beautiful work 😍. Now the search for what determines species-specific rates of protein turnover starts!

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Teresa Rayon

@t_rayon

1 year

Revisiting the inverse scaling of somatic mutation rates with lifespan paper: @ATJCagan @imartincorena ~3X variation of mutation load per cell at the end of lifespan across species No association with body mass, basal metabolic rate or litter size

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Teresa Rayon

@t_rayon

2 years

Transient inhibition of epigenetic regulators in progenitors leads to faster maturation in 👤 cortical neurons. *Is the mechanism conserved in 🐭? The 🧠 cortex is quite divergent across species *What changes between fast- & slow-maturing neurons? Congrats to the team!!🍾👏🏻🎉

Gabriele Ciceri

@gabriele_ciceri

2 years

Why human neurons mature so slow? Is it possible to accelerate their maturation? Excited to share our work as a preprint. We tackled this question using human pluripotent stem cells (hPSC). Thanks to everybody involved in this work @studerl 1/8

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Teresa Rayon

@t_rayon

3 years

*Today* Models & tools to investigate dynamics and timing 🐭⌛️👤⏳. 19h BST// 14h EDT. 4x short talks + panel discussion.

ISSCR

@ISSCR

3 years

Part 2 speakers will discuss how the dynamic and timing of embryogenesis can be deciphered using new synthetic biology tools. Join us on 20 April! #ISSCRDigital @Pulin_Li @ElowitzLab @t_rayon @LeonardoMorsut @nmoris

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Teresa Rayon

@t_rayon

3 years

~One year ago our paper #aboutime 🐭⏳👤⌛️was published. It amazes me how spot on are some of the comments from the readers of the piece on @arstechnica

When building an embryo, timing is everything

Mice take 21 days from egg to animal, humans take nine months. How's that managed?

arstechnica.com

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Teresa Rayon

@t_rayon

4 years

Really excited to give a talk at the @SEBiolDev meeting. Last year the EDBC meeting in Alicante was a blast! Final program is out: Will you attend this year?

I’ll see you there

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I won’t see you there

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Teresa Rayon

@t_rayon

4 years

Happy #WomenInScienceDay to all the sheroes that keep going!! Scientist was a term coined for HER ⤵️

Albert-László Barabási

@barabasi

5 years

The first scientist was a woman! The term was coined for Mary Somerville, to avoid calling her a 'man of science'. I learned something new, @Magda_Skipper --thanks for the inspiring talk and the visit @NUnetsi !

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Teresa Rayon

@t_rayon

3 years

Una iniciativa súper original y llena de potencial. Tengo muchísimas ganas de participar en Wow!Science 👩‍🔬

Aida Platero-Luengo 👩‍🔬🧠🔬

@aidaplat

3 years

Nuestro siguiente Wow!Science desde @ibis_sevilla con la inigualable @t_rayon , asegurada ciencia de la buena y arte en la diseminación cientifica. No dudes en unirte a #WowScience . Escribenos para el link virtual. @unisevilla

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Teresa Rayon

@t_rayon

3 years

Great panel & discussions on gastrulation and adapting the 14-day rule for human embryo research on the first day of the #ISSCR2021 . This @Dev_journal article on beliefs about ensoulment and individuality in various religions is one of a kind 👇👇👇

The status of the human embryo in various religions

Summary: This Spotlight article briefly describes how several different religions perceive the human embryo, and considers how this might influence their view of human embryological research.

journals.biologists.com

ISSCR

@ISSCR

3 years

Join us for Plenary Roundtable: Fascination with Gastrulation in 5 minutes! #ISSCR2021 @CWRUSOM @harvardmed @EPFL_en @HDR_Inc @_Hubrecht @LUMC_Leiden

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Teresa Rayon

@t_rayon

3 years

Curious to see the number of #devbio labs implementing it in the coming years. ~80% survival may make it compatible with studies of genetic mutant alleles inherited 1/8 & “delayed” phenotypes. next in my wishlist: combined with imaging 🙏

Ex utero mouse embryogenesis from pre-gastrulation to late organogenesis

Nature - A new culture system makes it possible to grow mouse embryos and study their development outside the uterus up to the point of late organogenesis.

www.nature.com

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Teresa Rayon

@t_rayon

6 years

My very first #PreLight highlighting a #preprint from the Sharpe’s lab. A nice initiative to give feedback by @Co_Biologists

preLights

@preLights

6 years

Geometric morphometrics for quantifying developmental defects – analysis of spatio-temporal gene expression in numbers

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Teresa Rayon

@t_rayon

3 years

All the data is available at to explore. Datasets and code also available. We hope that the community finds it useful!! *Special thanks to the reviewers and @Dev_journal for making the process constructive and smooth.

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Teresa Rayon

@t_rayon

8 months

@CABD_UPO_CSIC @TschoppLab @JLopezrios_ @mamartl @tzinicris_p @guillaumeandrey @der_bri it's been fon! great discussions about evolution, cross-species comparisons and enhancer logic. Including @JaneReznick , @m_osterwalder and twitterless Maude Baldwin 🦜

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Teresa Rayon

@t_rayon

1 year

Coding and regulatory changes increase TRNP1 activity and are positively selected either as a cause or a consequence of increases in brain size and cortical folding. Phylogenetic comparisons & massively parallel reporter assay. What’s not to like from this work 👇🏻👇🏻👇🏻

Enard/Hellmann Lab

@EnardHellmannWG

1 year

Our paper on TRNP1 co-evolution with brain size and folding is finally out in @eLife ! Here, we combine the analysis of both protein and regulatory sequence evolution across a broad range of mammals.

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Teresa Rayon

@t_rayon

5 years

Paper from Auston Smith’s lab confirming a role for Rbpj (Notch in our case) blocking naïve pluripotency always nice to read similar findings from various labs 🙂

Sergio Menchero

@sermenchero

5 years

The final version of our previous #preprint on #Notch activity during preimplantation development is now out in @eLife Transitions in cell potency during early mouse development are driven by Notch

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Teresa Rayon

@t_rayon

3 years

Merry Christmas to everyone! ❄️ 🧫 🧬🐭 🧪👤🔬 *🍾👩🏼‍🔬*

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Teresa Rayon

@t_rayon

1 year

Congrats to #ERCStG awardees & to all of those that put in the effort. - Success rate is higher than 2021.🤞funding trend continues - Writing the proposal is useful, regardless of the outcome - No UK association in 2021 = funds for EU researchers up on the waiting list

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Teresa Rayon

@t_rayon

2 years

New human transcriptomic atlas covering gestational weeks 4-6. Includes various organs & validates our findings on the spinal cord 👏😍. *Propose a global temporal regulation in development based on the conserved dynamic expression of LIN28A across tissues in vertebrates.

Yichi Xu

@Sheets76829215

2 years

Our preprint online! 1) First single-cell transcriptome of whole human embryos at CS12~16; 2) 333 cell types with deep annotation; 3) high-resolution map of limb bud with 14 spatial domains; 4) paralogous compensation of a master TF; 5) systemic temporal regulation in vertebrate.

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Teresa Rayon

@t_rayon

4 years

“Estábamos dedicados en comprobar la diferencia entre los bailarines de la coreografía, cuando realmente la diferencia reside en la música que bailaban.” Gracias @amloii por cubrir nuestro artículo @TheCrick 👩🏼‍🔬📢🧫⌛️🐭⏳🚻

Descubren por qué unos animales necesitan más tiempo de embarazo que otros

www.larazon.es

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Teresa Rayon

@t_rayon

6 years

Human Specific Notch-2NL isoforms cause the expansion of human neocortex. Nice to see the finding coming from three different labs, and with mechanistic insight

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