Shi Huang 黄石 @shi_huang5 Twitter profile

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Shi Huang 黄石

@shi_huang5

4 months

10 major events in 2023 regarding the Out of East Asia theory (OOEA)

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Shi Huang 黄石

@shi_huang5

1 year

Ancient DNA of over 40000 year old from Europe and East Asia has effectively and completely killed off the Out of Africa hypothesis. There is simply no way for it to be salvaged!

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Shi Huang 黄石

@shi_huang5

1 year

Our latest paper. We show that genetic diversity is a new genetic factor in cognition, challenging the Out of Africa model. GD in human is under selection and has little to do with long evolutionary time or being human ancestors.

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Shi Huang 黄石

@shi_huang5

1 year

@CharlesL1902 @charliewyrd The field is committed to out of Africa too deeply to qualify as objective, and its silence speaks volumes. So far, it has been silent on whether the aDNA in Europe and E Asia is evidence for Out of Africa. If not, what could it be? Can't be irrelevant. Can only be Falsifying!

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Shi Huang 黄石

@shi_huang5

1 year

@luix The authors were silent on whether these aDNAs are evidence for out of Africa. So, they cannot be evidence for it. They therefore can either be against it or irrelevant. But it can't be irrelevant since ooa predicts aDNA at that age should be African like.

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Shi Huang 黄石

@shi_huang5

3 years

That Africans carry more ancestral alleles (=archaic or apes) has been well demonstrated by the rooting of phylogenetic trees in Africa for both autosomes and uniparental DNAs by using the outgroup rooting method. Biological significance of this？Eerie silence...

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Shi Huang 黄石

@shi_huang5

1 year

@NorvinHobbs14 NO. All European Y haplotypes are downstream of F and F originated in East Asia. So, just like Bacho Kiro cave aDNA came from E Asia, so are all European Y haplotypes. Why Africans did not go into Europe via M East? OoA is sooo convoluted, it's embarrassing!

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Shi Huang 黄石

@shi_huang5

1 year

Whether there is a superior race is a scientific question and can only be answered by highly qualified geneticists after a thorough scientific investigation. For lay people to have a no answer to such a question prior to investigation is bizarre, non-scientific, and pure politics

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Shi Huang 黄石

@shi_huang5

1 year

The San have the highest GD and the lowest cognition/civilization in humans and are believed to be the ancestors, i.e., Out of Africa. The only alternative is the maximum GD theory that GD has an upper limit, which is inversely proportional to brain function or complexity. 2/6

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Shi Huang 黄石

@shi_huang5

2 years

"Next time you hear the words 'junk DNA,' remember it's not junk. If you look much, much closer, it's really an ever-changing blueprint for navigating the genome."

Live cell DNA architecture in real time

Inside the nucleus of a human cell, there are approximately two meters of DNA folded into a multi-layered 3D structure called chromatin, which allows all of our genetic information to be compacted...

phys.org

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Shi Huang 黄石

@shi_huang5

1 year

Some people are inherently not suited for the science profession, including reality deniers, defined as: A subconscious defense mechanism characterized by refusal to acknowledge (or rationalization of) unwanted or unpleasant facts, realities, thoughts, or feelings.

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Shi Huang 黄石

@shi_huang5

1 year

Low cognition is subject to natural selection, and so the underlying GD must be also rather than being time-related and not subject to natural selection as assumed by the molecular clock and neutral theory. The finding challenges the assumption of the OOA model. 6/6

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Shi Huang 黄石

@shi_huang5

2 years

Reviewer 1: "If this paper is correct, it would completely overturn current understanding of evolution, mutation, phylogenetics and human population history. Text books would need to be rewritten from scratch. It is an extraordinary claim."

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Shi Huang 黄石

@shi_huang5

1 year

This inverse relationship holds well among species (the higher the complexity, the lower the GD), which means that the highest GD of the San may be the reason for their cognition level being the lowest. The origin of humans may actually not be in Africa but in E Asia. 3/6

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Shi Huang 黄石

@shi_huang5

1 year

@FXescoli From the literature by OoA believers, European Y chr, X chr, and autosomes all came from East Asia. This way of into Eur from Afr is unnecessarily convoluted and complex, and so bad according to Occam's razor. In contrast, it is exactly to be expected from our out of E Asia model

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Shi Huang 黄石

@shi_huang5

1 year

Among 17 traits examined, only education attainment, a proxy of IQ, has the best association (inverse) with GD. Only brain-expressed genes, but not brain-non-expressed, showed an association. The association of non-syn variants is higher than that of syn or intronic variants. 5/6

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Shi Huang 黄石

@shi_huang5

2 years

I proposed the maximum genetic diversity theory in 2008 as a comprehensive molecular evolutionary theory to supersede the flawed neutral theory and molecular clock. The theory has now found itself in a textbook by prof. David Bickel of U. of N. Carolina.

Testing Hypotheses of Molecular Evolution

This chapter lifts the uncertainty quantification of the previous chapters up to the level of molecular evolution hypotheses. A relatively recent rival to the neutral theory of molecular evolution is...

link.springer.com

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Shi Huang 黄石

@shi_huang5

1 year

Our study analyzed genotype/phenotype from more >400,000 people in the UK, calculated multiple measures of GD for each individual, and examined which traits these measures were associated with using linear regression analysis that has controlled for confounding factors. 4/6

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Shi Huang 黄石

@shi_huang5

5 years

Batwa pygmies have higher genetic diversities than Bantu Bakiga people, which is maintained by selection as shown by numerous data including this new paper, invalidating the neutral assumption underlying the Out of Africa model.

George (PJ) Perry

@grg_perry

5 years

Excited abt our new @NatureEcoEvo paper led by @GeneScientist17 & @LB_Barreiro , on evolutionary genomics of cellular immune response differences between African rainforest hunter-gatherers (Batwa) & agriculturalists (Bakiga). Results opposite of expected!

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Shi Huang 黄石

@shi_huang5

1 year

@willwbooker Max Planck: “A new scientific truth does not triumph by convincing its opponents and making them see the light, but rather because its opponents eventually die and a new generation grows up that is familiar with it ...” So, do you think the opponents of new truth are unethical?

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Shi Huang 黄石

@shi_huang5

2 years

”Scientists at Caltech may have sounded the final death knell for the “junk DNA” myth. If only Dan Graur had known this years ago, it might have saved a lot of wasted rhetoric. “ Neutral theory is doomed. MGD is blessed!

Caltech Finds Amazing Role for Noncoding DNA | Evolution News

There’s more function in the “junk” than imagined. Caltech finds a significant role: maintaining territories and compartments, and guiding components.

evolutionnews.org

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Shi Huang 黄石

@shi_huang5

2 years

Assuming 100 human groups (a conservative underestimate) with different levels of genetic diversity and IQ, the group with the highest genetic diversity (Bushman in Southern Africa) also happens to have the lowest IQ by chance is 1/100. 1/

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Shi Huang 黄石

@shi_huang5

1 year

@Phillip05166897 @luix OOA can't possibly predict that aDNA of that age in Europe should be E Asian like. But they are, and fully match the prediction of the out of East Asia model. No comparison, no harm.

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Shi Huang 黄石

@shi_huang5

1 year

The popular definition of racism in the West is pure non-sense! It considers ranking people to be racism. Anyone who does that is considered a racist. The tacit assumption here is that the authors of the definition know for a fact that races are equal in genotypes/phenotypes. 1/3

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Shi Huang 黄石

@shi_huang5

1 year

If trait X is a mark of progress in human evolution, the group with the highest frequency of X should be the first to become modern and remains today with the highest frequency. That group is E Asian. This supports out of E Asia but not Africa. (X = most traits in the table)

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Shi Huang 黄石

@shi_huang5

1 year

@Phillip05166897 @luix People were mixing and it is impossible for a lineage to die out so completely. Besides, to claim early aDNA lineages all died out would make it impossible to test OOA. If it can't be tested by aDNA, it is pseudoscience. But our Asia model got confirmed by aDNA just fine.

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Shi Huang 黄石

@shi_huang5

2 years

"People expected the oldest remains to resemble more and more those of a chimpanzee, but that’s not the case" -- Tim White

‘We don’t know from which creature humans and chimpanzees evolved’

US paleoanthropologist Tim White, a living legend in his field, has moved to Spain to continue his quest to uncover the distant origins of ‘Homo sapiens’

english.elpais.com

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Shi Huang 黄石

@shi_huang5

11 months

"DNA leaves little doubt: All non-Africans alive today descend from a single wave of migration out of Africa." This is a lie. There are big uncertainties regarding OOA because the underlying neutral theory is uncertain and faces challenge from MGD theory

Ancient humans traveled half the world to Asia before main migration out of Africa

Discovery deep in Laotian cave shows humans voyaged out of Africa by at least 68,000 years ago

www.science.org

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Shi Huang 黄石

@shi_huang5

2 years

NS theory was found by 5 English men. One cannot imagine a truly great idea that has solved a hard problem can come to more than one genius.

New evidence proves Darwin stole Theory of Evolution from rival

A new book argues there are overwhelming similarities between Darwin's seminal On The Origin Of Species and an earlier work by a naturalist called Patrick Matthew.

www.dailymail.co.uk

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Shi Huang 黄石

@shi_huang5

11 months

Tibetans also have the highest genetic diversity or heterozygosity among all Chinese. The inverse correlation between genetic diversity and cognition is perfect.

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Shi Huang 黄石

@shi_huang5

2 years

Russell: When you are studying any matter, ..ask yourself only what are the facts and what is the truth that the facts bear out. Never let yourself be diverted, either by what you wish to believe, or by what you think would have beneficent social effects if it were believed.

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Shi Huang 黄石

@shi_huang5

1 year

@DavidBahry Those fossils are all mosaics of modern and archaic and E. Asia have plenty of those too. Besides, the earliest modern, Jebel Irhoud, is found in North Africa, not exactly the place you would find based on highest genetic diversity. And yet high GD is the key reason for OOA

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Shi Huang 黄石

@shi_huang5

2 years

Why a preprint is enough? If one is an expert, one should have no problems in judging a preprint in his field. If one is an outsider, one must rely on peer reviewers. But a paper is meant to impress experts rather than anybody else. Vested interest always blocks revolution.

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Shi Huang 黄石

@shi_huang5

3 years

German Dziebel : aDNA samples from the first Eurasians show none of those uniparental lineages known from modern African populations. YDNA and mtDNA haplogroups detected in Tianyuan, Ust’-Ishim, Pe"tera cu Oase, Kostenki, Mal’ta, Bacho Kiro, etc. 1/4

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Shi Huang 黄石

@shi_huang5

2 years

Such low probability suggests that the observed link between genetic diversity and IQ (the higher the genetic diversity the lower the IQ) is unlikely to be chance. 3/3

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Shi Huang 黄石

@shi_huang5

1 year

“Physicists using modified MRI machines say they may have found quantum entanglement between the heart and brain." Chinese since ancient times consider the heart to be the thinking organ. The most influential thought is termed 心学

A “Quantum Brain” Could Solve The Hard Problem of Consciousness, New Research Suggests - The Debrief

New research points to quantum entanglement in the brain, suggesting that a "quantum brain" might solve the hard problem of consciousness.

thedebrief.org

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Shi Huang 黄石

@shi_huang5

3 years

"We used to believe that the role of the nucleotides was to encode amino acids, but now we see that, actually, proteins with the same amino acid sequence have different translation rates, and that makes a difference in their function."

Protein's 'silent code' affects how cells move

The protein actin is ubiquitous and essential for life. In mammals, every cell expresses two of its forms, beta-actin and gamma-nonmuscle-actin. Despite having distinct roles, the two forms are...

phys.org

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Shi Huang 黄石

@shi_huang5

9 months

Admixture is under negative selection, which favors evolution towards lower genetic diversity!

Racial Pairings and Fertility: Do Interracial Couples Have Fewer Children?

Our overall goal is largely descriptive—to compare recent fertility patterns between racially endogamous and exogamous couples in the United States. Evidence of lower fertility among exogamous or...

www.ncbi.nlm.nih.gov

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Shi Huang 黄石

@shi_huang5

1 year

Hetao man is modern human found in Hetao, Inner Monglia China. New dating shows an age of 70000-140000 years, thus representing one of earliest modern humans in E. Asia. This makes the out of Africa model invalid and supports the Out of E Asia model.

“河套人”的发现

finance.sina.com.cn

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Shi Huang 黄石

@shi_huang5

2 years

The group with the lowest genetic diversity (East Asians) happens to have the highest IQ by chance is also 1/100. For both of these chance events to occur, the probability is 1/10000. 2/

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Shi Huang 黄石

@shi_huang5

1 year

@BareNatMatt Evolution has a progressive direction from simple to complex or from more random noise within the system to less noise, which is what science has found out, at least my science. This would put human at the top. The same logic would equally apply to different people.

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Shi Huang 黄石

@shi_huang5

1 year

The definition of racism implies that E Asians are all racists as their culture have valued ranking and 圣人(Saints), as Mengzi stated 2300 years ago :“夫物之不齐，物之请也。” (That things are non-equal is the inherent nature of things). So, the definition itself is racist!

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Shi Huang 黄石

@shi_huang5

5 months

Bo Wingard @EPoe187 :“To be a racist is one of the great evils of our time.” Why not define a racist as an evil person who uses racial differences as mere excuses for evil action when those differences are not sufficient for normal people to do evil?

What is a racist?

Like nervous children who hear a monster in every creaking floor, many journalists and academics see a racist in every joke or story that does not conform to current progressive sensitivities.

www.aporiamagazine.com

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Shi Huang 黄石

@shi_huang5

2 years

New large scale sequencing effort found evidence of recurrent mutations in fast evolving sites and non-neutrality for syn sites, invalidating the infinite site model and the neutral theory and confirming the maximum genetic diversity theory.

The sequences of 150,119 genomes in the UK Biobank

Nature - To measure selection on variants, whole-genome sequencing of approximately 150,000 individuals from the UK Biobank is used to rank sequence variants by their level of depletion.

www.nature.com

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Shi Huang 黄石

@shi_huang5

1 year

The inverse association between cognition and GD is universal. No exceptions. Just an example. Tibetans have the highest number of SNPs among Chinese but lower IQ than Han living in Tibet. Low GD due to inbreeding is not the same as that not related to inbreeding.

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Shi Huang 黄石

@shi_huang5

2 years

New function found for junk DNA, aka, neutral DNA. Neutral theory and its deductions like the out of Africa model are doomed.

Xinyang Bing

@XinyangBing

2 years

Fantastic collaboration with @philippe_batut ! We address some important controversies regarding insulators with live imaging and Micro-C, and present a novel class of architectural elements - #tetheringelements . Lots of #3Dgenome Easter eggs hidden in this one, give it a read!

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Shi Huang 黄石

@shi_huang5

2 years

Absurd! Everything is connected and hiding one piece of reality will surely hurt understanding other parts of reality. The science of race difference in traits is critical to our understanding of where and how humans evolved.

Paolo Shirasi

@PaoloShirasi

2 years

Scientific American opinion piece asks whether we should ban research into race IQ gaps, and answers the question with a "yes".

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Shi Huang 黄石

@shi_huang5

1 year

@cschlebu Is it not a valid question to ask whether genetic diversity is under natural selection or not? The field never examined this and just assumed GD is not under NS. The OoA is based on that uncertain assumption. How can you then believe the model be a certain truth?

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Shi Huang 黄石

@shi_huang5

1 year

@StevePittelli Nazis are saying much more and worse. They believe that the top ranked is entitled to oppress and exploit the bottom ranked, which has no logical and scientific basis and is the real harm. Ranking in itself does not result in harm! Does college entrance exam cause harm?

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Shi Huang 黄石

@shi_huang5

3 years

all stem from a shared, pan-human set of mutations with some basal markers characteristic of the major non-African macrohaplogroups such as mtDNA R, N and YDNA P and C. This is not good news for the out-of-Africa theory. 2/4

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Shi Huang 黄石

@shi_huang5

1 year

@NorvinHobbs14 Not according to our tree. F is the root in our tree, which has passed the aDNA test as we showed in this paper . But again, the field is silent on whether its out of Africa tree for Y chr has passed or failed the aDNA test.

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Shi Huang 黄石

@shi_huang5

2 years

@chrislibertynow @Harvard2H Ancient uniparental DNAs in distinguishing the competing theories of molecular evolution and modern human origins

Ancient uniparental DNAs in distinguishing the competing theories of molecular evolution and modern...

Analyses of extant people have resulted in two models for the uniparental DNA phylogenetic trees of modern humans rooted in either Africa or East Asia. The Africa model is based on the neutral...

www.researchsquare.com

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Shi Huang 黄石

@shi_huang5

10 months

"science—and here we are speaking of all STEM fields (science, technology, engineering, and mathematics)—has become heavily tainted with politics, as “progressive social justice” elbows aside our real job: finding truth." - Jerry Coyne, Prof Evol Biol.

The Ideological Subversion of Biology | Skeptical Inquirer

SUMMARY: Biology faces a grave threat from “progressive” politics that are changing the way our work is done, delimiting areas of biology that are taboo and ...

skepticalinquirer.org

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Shi Huang 黄石

@shi_huang5

1 year

Southern Europeans (TSI, IBS) are known to have lower IQ scores than Northern Europeans (GBR, FIN), which correlates with genetic diversity (heterozygosity) but not with educational attainment PGS scores. Genetic diversity is a stronger component in cognition than IQ linked SNPs?

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Shi Huang 黄石

@shi_huang5

2 years

One can be sure that any argument for junk DNA that is based on the existing theoretical framework of evolution cannot possibly be right, because the framework is far from complete. Paper shows that "mutational load" arguments don't refute ENCODE findings

Paper shows that "mutational load" arguments don't refute ENCODE...

When the ENCODE project first proposed, on the basis of direct empirical research, that 80 percent of the genome may be biochemically functional, a huge prediction of intelligent design was...

www.sott.net

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Shi Huang 黄石

@shi_huang5

1 year

This definition prohibits research on ranking. It also prohibits one from looking for proof for the assumption underlying the definition that all races are equal. Thus the definition in and of itself is plain anti-science, anti-truth, and anti-itself. 3/3

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Shi Huang 黄石

@shi_huang5

3 months

If Out of Africa is true that Afr are the most advanced humans at ~50 kya, how come they have since become the least advanced? How could Africa be the most suitable place for progress before 50 kya but the least after that? Such contradiction has only one solution, OOA is false!

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Shi Huang 黄石

@shi_huang5

1 year

Ancient Chinese teachings (>2000 year old): 仁、善（benevolence and kindness）勿以身贵而贱人 (you should not bully the weak just because you are strong ) It is time for the West to learn the ancient wisdom that strong does not necessarily mean oppression of the weak！

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Shi Huang 黄石

@shi_huang5

11 months

The new data shows that admix reduces IQ, consistent with the maximum genetic diversity theory.

Crémieux

@cremieuxrecueil

11 months

New estimates of IQs by ethnicity from a large, nationally-representative sample of American kids have been released. Here's what they look like.

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Shi Huang 黄石

@shi_huang5

1 year

When you are studying any matter..., ask yourself only what are the facts and what is the truth that the facts bear out. Never let yourself be diverted either by what you wish to believe or by what you think would have beneficent social effects if it were believed--B. Russell

Steven Pinker

@sapinker

2 years

Scientists are under no more obligation to portray humans as "dignified" than are war historians, political reporters, or gastroenterologists. Their obligations are accuracy and rigor.

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Shi Huang 黄石

@shi_huang5

5 years

Our maximum genetic diversity (MGD) hypothesis was inspired by one of the most astonishing findings in science, the genetic equidistance result in 1963, that has been mis-interpreted by the molecular clock and in turn the evolutionary theory as authored by Kimura and Darwin.

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Shi Huang 黄石

@shi_huang5

8 months

Thick enamel and open living condition of this new 8.7 ma fossil Anadoluvius from Turkey suggests that it may belong to the human branch separate from the pongid (including all non human great apes).

New ancient ape from Türkiye challenges the story of human origins

A new fossil ape from an 8.7-million-year-old site in Türkiye is challenging long-accepted ideas of human origins and adding weight to the theory that the ancestors of African apes and humans evolved...

phys.org

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Shi Huang 黄石

@shi_huang5

1 year

Society should not allow these people to dictate what can or cannot be investigated by science!

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Shi Huang 黄石

@shi_huang5

1 year

Bacho Kiro cave (Bulgaria) ~45000 year old aDNA is most similar to East Asians rather than Europeans or Africans. Isn't this direct evidence for our out of E Asia model? But the authors and the field are silent on this. Is this science or politics?

Initial Upper Palaeolithic humans in Europe had recent Neanderthal ancestry

Nature - Genome-wide data for the three oldest known modern human remains in Europe, dated to around 45,000 years ago, shed light on early human migrations in Europe and suggest that mixing with...

www.nature.com

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Shi Huang 黄石

@shi_huang5

1 year

But that assumption is unfounded and could be proven wrong by research. When that happens, the definition automatically becomes invalid or anti-science. 2/3

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Shi Huang 黄石

@shi_huang5

3 years

Africa had no human fossils found in the period from 1-50000 years ago. If OOA is true, one would expect to see a large number of people in Africa at the time when people started to move into Eurasia at 50kya.

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Shi Huang 黄石

@shi_huang5

1 year

African Middle Stone Age tools lasted from 300 to 10 kya. One expects new tools to be invented by more modern people at 100-50 kya. W Africa should have these new tools as moderns migrated to Eurasia. No evidence for archaic to modern evol in Afr?

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Shi Huang 黄石

@shi_huang5

1 year

Evolution is known as a decrease of entropy, as it involves things getting more organized or complex over time. Paradoxically, it is also known as an increase in genetic diversity or entropy in DNA. Our Maximum GD theory is the first to show a decrease in GD as life gets complex.

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Shi Huang 黄石

@shi_huang5

2 years

"even relatively “simple” complex traits such as molecular biomarkers are highly polygenic with ∼10000 causal variants spread widely across the genome, compared to ∼100000 or more variants for traits such as height or BMI"

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Shi Huang 黄石

@shi_huang5

1 year

To put politics ahead of science is bad for science and also for humanity in the long run. Lewontin's politics and science (race is not real as most genetic variants are shared) will be overturned when humans eventually grasp the real meaning of genetic diversity.

dialecticbio.bsky.social

@DialecticBio

3 years

"To do science is to be a social actor engaged, whether one likes it or not, in political activity" One of the greatest passages from Richard Lewontin's 'Dialectical Biologist' (1985)

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Shi Huang 黄石

@shi_huang5

2 years

“Right now I find myself lying awake at three in the morning,” says Alison Kirkpatrick, an astronomer at the University of Kansas in Lawrence, “and wondering if everything I’ve done is wrong.”

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Shi Huang 黄石

@shi_huang5

19 days

Wonder whether biracial people with white mother and black father may have higher IQ than those with black mother and white father? I expect yes based on purely genetic and epigenetic reasoning with no regard to nurturing issues. Any research on this? @sebjenseb @charlesmurray

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Shi Huang 黄石

@shi_huang5

3 years

Within the same time frame (~ 50K years), modern humans in Eurasia have evolved more modern alleles (non-Archaic and non-Ape) than those in Africa. So, Eurasia are more suitable than Africa for modern genes to evolve, or for H. erectus to evolve into modern humans.

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Shi Huang 黄石

@shi_huang5

3 years

"Tumor genomics differed by race even after accounting for clinical characteristics." The Lewontin's idea of race as a social construct is pure wishful thinking based on flawed genetic research and harmful to African health!

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Shi Huang 黄石

@shi_huang5

2 months

Ancient paternal DNA shows migration of modern humans from East to West. All agree that F originated in East Asia and is the ancestor of K2a. The earliest European Y haplotype is K2a (Ust-Ishim 45kya and Oase1 40 kya). Yet, you don't see this mentioned or discussed.

Shi Huang 黄石

@shi_huang5

2 months

Not a single word in the review on making use of aDNA to test Out of Africa. Because it can't pass the test? Our paper shows No, it can't. Ancient uniparental DNAs in distinguishing the competing theories of molecular evolution and modern human origins

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Shi Huang 黄石

@shi_huang5

3 years

Out of Africa derives from the neutral assumption, the higher the genetic diversity, the longer the evolution time. That sub-Saharans have the highest genetic diversity is an undisputed reality (higher than N. Africans). The believers of neutral theory interpret this as OoA: 1/5

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Shi Huang 黄石

@shi_huang5

2 years

We propose that coding and noncoding nascent RNAs, including those produced by retrotransposons, may facilitate ‘hijacking’ of transcriptional condensates in various developmental and disease contexts.

Hijacking of transcriptional condensates by endogenous retroviruses

Nature Genetics - TRIM28 depletion in embryonic stem cells disconnects transcriptional condensates from super-enhancers, which is rescued by knockdown of endogenous retroviruses.

www.nature.com

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Shi Huang 黄石

@shi_huang5

11 months

Of the two competing theories of modern human origins, out of Africa vs East Asia, which is supported by the new data of modern homo in East Asia much earlier than the supposed ancestors of E Asians from Africa? OOA lost again!

Early presence of Homo sapiens in Southeast Asia by 86–68 kyr at Tam Pà Ling, Northern Laos

Nature Communications - Here the authors report new human fossils from Tam Pà Ling cave, Laos, consisting of a cranial and a tibial fragment, dated to 68–86 thousand years ago. This find...

www.nature.com

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Shi Huang 黄石

@shi_huang5

1 year

Modern humans were present in Eurasia at 300-70 ky ago, long before the original molecular dating for the out of Africa event at ~50 kya. These include Dingcun, Panxian Dadong, Hualongdong, and Daoxian fossils in China, which all have local features such as shovel teeth. 1/2

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Shi Huang 黄石

@shi_huang5

1 year

The Out of Africa model was deduced from uncertain assumptions (molecular clock neutral theory) and so not a certain truth. For the West to promote it as certain is not standard scientific practice. Scholars have criticized it as driven by politics.

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Shi Huang 黄石

@shi_huang5

3 years

One possible explanation for this pattern is that the conventional trees of divergence of uniparental lineages—the bulwark of out-of-Africa thinking—must have got it backwards, that the “molecular clock” is wrong 3/4

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Shi Huang 黄石

@shi_huang5

2 years

Miscarriages due to genetic errors are one way to maintain low levels of maximum genetic diversity in humans.

Genetic errors cause most miscarriages, confirms largest study yet

After analysing the tissue of nearly 25,000 miscarriages, researchers found more than half were caused by randomly occurring chromosomal abnormalities, with many of the remaining losses probably...

www.newscientist.com

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Shi Huang 黄石

@shi_huang5

1 year

@DrMatt1990 follow this latest paper using aDNA to prove out of East Asia and to disprove out of Africa, and follow the references within for the earlier papers by us. Note that our opponents have no interest to verify their model by using aDNA

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Shi Huang 黄石

@shi_huang5

3 years

and that it is the most frequent alleles (and not the most divergent ones) that must be deemed basal in a phylogeny. This new set of assumptions has become the cornerstone of an “out-of-Asia” hypothesis 4/4

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Shi Huang 黄石

@shi_huang5

2 months

Some racial groups such as Khoe-San carry more ancestral alleles (AAF: AA freq), i.e. chimpanzee alleles, and hence less modern than other people in whom the derived alleles are fixed. This makes sense with known traits. But it is a sensitive topic. … 📷

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Shi Huang 黄石

@shi_huang5

4 years

Excited to share our latest preprint. Ancient DNA is the ultimate test of a phylogenetic tree. No one has claimed that the Out of Africa model has passed the test. Now we know the reason. It has failed the test for both the mtDNA and Y trees.

Ancient Y chromosomes confirm origin of modern human paternal lineages in Asia rather than Africa

Analyses of Y chromosome variations of extant people have resulted in two models for the paternal phylogenetic tree of modern humans with roots either in Africa or East Asia. These two trees are...

www.biorxiv.org

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Shi Huang 黄石

@shi_huang5

1 year

The oldest fermented drink was found in pottery jars from the Neolithic village of Jiahu, in Henan province, Central Northern China.

Human Origins at SI

@HumanOrigins

1 year

Today is #NationalBeerDay ! People have been consuming fermented beverages for thousands of years; one of the earliest pieces of evidence comes from a 9,000-year-old container from China found in 2021 that left traces of a fermented drink. @NationalBeerDay

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Shi Huang 黄石

@shi_huang5

1 year

"The mechanical code, i.e., the mapping between the local sequence and the local deformability of DNA." Really bad news for the junk/neutral DNA school, as all DNAs should be involved in the mechanical code. DOI: 10.1038/s41594-022-00877-6

Scientists Have Decrypted the “Mechanical Code” of DNA

An international team of researchers, led by Durham University in the UK, has uncovered previously unknown ways in which nature encodes biological information in a DNA sequence by deciphering the...

scitechdaily.com

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Shi Huang 黄石

@shi_huang5

1 year

To origin models, ancient DNA can be proof, falsification, or noninformative. The latter two deem the model wrong or non-testable/pseudoscientific. The Out of Africa camp has been silent on what ancient DNA means for its model, which is a clear sign the model is dead wrong!

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Shi Huang 黄石

@shi_huang5

4 years

"Although [70%] of the human genome is indeed closer to chimpanzees, on average, a sizable minority of 15% is in fact closer to gorillas", confirming what we wrote before: Great apes are equally related to human in genealogy but not in functional DNA MGD. .

Gorillas More Related to People Than Thought, Genome Says

The first complete gorilla genome also reveals surprising differences, such as gorilla gene that aids knuckle walking.

www.nationalgeographic.com

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Shi Huang 黄石

@shi_huang5

3 years

The article lists dozens of theories by maverick scientists in history. They were first ignored and ridiculed, and then proved to be correct.

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Shi Huang 黄石

@shi_huang5

1 year

Another example of the universal inverse association between maximum genetic diversity and cognition. Basques have higher IQ and higher IQ PGS scores than other Europeans and their genomes have lower heterozygosity.

Aporia | Substack

Ideas for a future worth wanting. Click to read Aporia, a Substack publication with tens of thousands of subscribers.

www.aporiamagazine.com

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Shi Huang 黄石

@shi_huang5

2 years

Neutral theory was inspired by the molecular clock, which was inspired by the genetic equidistance result. Without understanding the genetic equidistance phenomenon, one cannot understand molecular evolution.

Erik Svensson

@EvolOdonata

2 years

I have developed these and other criticisms of Mayr's views in this forthcoming book chapter: 7/

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Shi Huang 黄石

@shi_huang5

11 months

Darwin followers do not admit progress or direction in evolution. But Darwin says this: "The more recent forms must, on my theory, be higher than the more ancient; for each new species is formed by having had some advantage in the struggle for life over other and preceding forms

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Shi Huang 黄石

@shi_huang5

8 months

Among homo fossils at ~1 million years ago, Yunxian skull from Hubei Central China is special as it has facial features similar to modern humans, which supports our molecular model that modern humans first appeared in East Asia.

Roberto Sáez

@robertosaezm

8 months

Homo erectus from the Yunxian and Nankin Chinese sites: Anthropological insights using 3D virtual imaging techniques

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Shi Huang 黄石

@shi_huang5

3 months

There are close to 10 modern fossil sites in Eurasia (3 in China) aged 60-30 ky, but there is only one in sub-Sahara Africa which however doesn't even look like Africans. What does this mean to origin models?🤣

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Shi Huang 黄石

@shi_huang5

1 year

If out of Africa were true, how could modern humans entering Eurasia from hot Africa at 50000 years ago adapt to the cold climate and compete with the people that had adapted to Eurasia for 2 million years?

Most humans haven't evolved to cope with the cold, yet we dominate northern climates—here's why

Humans are a tropical species. We have lived in warm climates for most of our evolutionary history, which might explain why so many of us spend winter huddled under a blanket, clutching a hot water...

phys.org

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Shi Huang 黄石

@shi_huang5

1 year

The migration of humans into Eurasia from Africa at ~2 million year ago led to human adaptation to and preference for more diverse biomes. This makes Eurasia, rather than Africa, the more suitable place for the birth of modern humans at ~100000 year ago.

Human adaptation to diverse biomes over the past 3 million years

Earth system modeling shows how Pleistocene hominins spread across and selected different habitats.

www.science.org

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Shi Huang 黄石

@shi_huang5

10 months

Afr hunter gatherers have the highest genetic diversity. Eurasians have lower GD, which is thought to be due to bottlenecks during OOA migrations. However, actual measures of bottlenecks (ROH) shows it is Afr HG that have high ROH. OOA is fiction

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Shi Huang 黄石

@shi_huang5

1 year

"Definitions are never set in stone, and the twists and turns of how racism has been defined illustrate how the meanings of such contentious terms are always subject to reevaluation and contestation." The authors who defined racism are unqualified!

The Evolution of 'Racism'

A look at how the word, a surprisingly recent addition to the English lexicon, made its way into the dictionary

www.theatlantic.com

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