Kamila Naxerova @naxerova Twitter profile

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Kamila Naxerova

@naxerova

2 years

Massive congrats to @ATJCagan & team on a foundational study of somatic mutation rates across species! In a little @NatureNV article 👇 we discuss their new findings, also with respect to another amazing paper on cancer mortality across zoo animals (1/2)

Mutational clocks tick differently across species

Nature - Long-lived species have a slower mutation rate than short-lived species.

www.nature.com

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Kamila Naxerova

@naxerova

4 years

Does metastasis involve selection for specific subclones? Lymph node mets: not so much! Distant mets: much more so! Check out our quantification of metastasis diversity, showing differential selection across metastatic sites in ⁦⁦ @NatureGenet ⁩

Lymph node metastases develop through a wider evolutionary bottleneck than distant metastases

Nature Genetics - Analysis of metastases using a mathematical framework and multi-region sampling data shows that lymph node metastases have higher levels of intratumor heterogeneity than distant...

www.nature.com

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Kamila Naxerova

@naxerova

2 years

This is very, very interesting... Cell division in tissues enables macrophage infiltration

Cell division in tissues enables macrophage infiltration

Embryonic tissue invasion by Drosophila macrophages requires epithelial cell division at the entry site.

www.science.org

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Kamila Naxerova

@naxerova

3 years

Genetic alterations can cause tissue pathology and disease. But diseases also shape the genetic composition of tissues! See below our new study on how increased HSC proliferation in atherosclerosis accelerates clonal hematopoiesis.

Increased stem cell proliferation in atherosclerosis accelerates clonal hematopoiesis

Heyde et al. propose that clonal hematopoiesis can be a symptom rather than a cause of atherosclerosis, since this disease increases hematopoietic stem cell division, which results in accelerated...

www.cell.com

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Kamila Naxerova

@naxerova

11 months

A most pleasant genetics class - perfect reading for a slow Friday evening.

Mendelian inheritance revisited: dominance and recessiveness in medical genetics

Nature Reviews Genetics - This Review discusses the importance of understanding the mechanisms by which specific allelic variants and allelic combinations cause disease for accurately diagnosing,...

www.nature.com

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Kamila Naxerova

@naxerova

3 years

Wow what a story. Makes immediate intuitive sense, so satisfying. This is how tissue-specific driver selection works. Developmental chromatin programs determine oncogenic competence in melanoma

Developmental chromatin programs determine oncogenic competence in melanoma

Chromatin factors serve as oncogenic competence factors for melanoma initiation.

www.science.org

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Kamila Naxerova

@naxerova

3 years

Genetic and non-genetic clonal diversity in cancer evolution | Nature Reviews Cancer

Genetic and non-genetic clonal diversity in cancer evolution

Nature Reviews Cancer - This Review discusses the role of functional (impacting tumour phenotype) and non-functional intra-tumour heterogeneity (ITH) in cancer evolution, highlighting the...

www.nature.com

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Kamila Naxerova

@naxerova

2 years

More food for thought about the connection between mutagenesis and carcinogenesis, which is turning out to be much more complicated than we previously thought, if I may say so.

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Kamila Naxerova

@naxerova

7 months

Our lab has moved! We are so excited to now be part of the incredible HMS Genetics department @HMSGenetics . The transition will allow us to expand on the basic & theoretical aspects of our research in somatic evolution and collaborate with lots of new illustrious colleagues!

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Kamila Naxerova

@naxerova

5 years

Watch macrophage soldiers in different countries (eh, organs) take to arms in response to remote danger! Very great and very long-running collaboration with Felix Hoyer and @MatthiasNahrend and team - now out in @ImmunityCP .

Tissue-Specific Macrophage Responses to Remote Injury Impact the Outcome of Subsequent Local Immune...

Hoyer, Naxerova, et al. generate a comprehensive catalog of changes in macrophage number, origin, and gene expression in the heart, brain, liver, kidney, and lung of mice with myocardial infarction,...

www.cell.com

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Kamila Naxerova

@naxerova

3 years

These four papers really are an incredible tour de force and add so much to our understanding of somatic evolution. Huge congratulations to all the authors and many thanks to the editorial team that shepherded this collection. @Nature @NatureNV Happy reading everyone!

Michelle Trenkmann

@MT_Genetics

3 years

Out in @Nature today is a fantastic quartet of papers reporting somatic mutation landscapes in normal human tissues and phylogenies of their embryonic origins, accompanied by a wonderful @NatureNV from @naxerova

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Kamila Naxerova

@naxerova

5 years

When a project gets handed from a departing postdoc to the next ... 😅

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Kamila Naxerova

@naxerova

3 years

Interrupting our regularly scheduled programming on tumor evolution… To share a systematic collection of genetic screens probing human embryonic stem cell behavior, out today in @GenesDev (1/n)

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Kamila Naxerova

@naxerova

10 months

Interesting topic. Single-cell genomics meets human genetics | Nature Reviews Genetics

Single-cell genomics meets human genetics

Nature Reviews Genetics - In this Review, the authors describe the emerging field of single-cell genetics, which lies at the intersection of single-cell genomics and human genetics. They review the...

www.nature.com

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Kamila Naxerova

@naxerova

5 years

@skathire I think “interestingly” (used sparingly) can actually be a good way of alerting readers that unexpected/novel results are about to be described. Particularly for students and people outside the field, such signal words can really help with navigation through the paper.

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Kamila Naxerova

@naxerova

1 year

Dissecting metastasis using preclinical models and methods | Nature Reviews Cancer

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Kamila Naxerova

@naxerova

3 years

Here comes the first installment of our #somatic_evolution journal club! Peter Nowell’s 1976 classic hit, “The Clonal Evolution of Tumor Cell Populations”. Nowell is the co-discoverer of the Philadelphia chromosome. (1/n)

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Kamila Naxerova

@naxerova

3 years

Excellent review - put it on your reading stack!

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Kamila Naxerova

@naxerova

2 years

Thank you @CellCellPress for giving us the opportunity to reflect a little bit on the amazing work of @jyoti_nangalia and team reconstructing MPN evolution, recently published in @nature . If this paper is still on your reading pile, pull it out now!

Eric Topol

@EricTopol

2 years

"More and more evidence suggests that the earliest events in the evolution of a cancer can predate diagnosis by several decades" Even in utero. @naxerova @CellCellPress Comment to

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Kamila Naxerova

@naxerova

5 months

We have open postdoc positions in our lab at the @HMSGenetics department! Are you interested in somatic evolution? Do you want to work in an exciting, collaborative environment at the heart of the HMS campus ? Enjoy a rich academic culture and friendly colleagues? More 👇

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Kamila Naxerova

@naxerova

3 years

Must read!!

Selection of metastasis competent subclones in the tumour interior

Nature Ecology & Evolution - The spatial and physical nature of tumour growth remains unclear. Combining whole-tumour images from clear cell renal cell carcinoma with genomic data, the authors...

www.nature.com

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Kamila Naxerova

@naxerova

2 years

Thanks so much to @TheMarkFdn for supporting our team! We will work very hard to make it count.

The Mark Foundation for Cancer Research

@TheMarkFdn

2 years

Congratulations Kamila Naxerova @naxerova @MGHCSB @MGH_RI

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Kamila Naxerova

@naxerova

2 years

This is an incredible finding that may go a long way to explain cancer type-specific copy number alteration patterns (in addition to selection which - if I am to guess - will be a smaller part of the story). Really mind-blowing work @KopsLab !!!

Nuclear chromosome locations dictate segregation error frequencies

Nature - Using single-cell DNA sequencing after an error-prone mitosis in untransformed, diploid cell lines and organoids, chromosomes are shown to have different segregation error frequencies that...

www.nature.com

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Kamila Naxerova

@naxerova

9 months

So many more mutations in British vs. Singaporean skin! Very notable how these results differ from the esophagus where mutation burden and signature composition did not much vary across countries with varying esophageal cancer incidence.

Somatic mutations in facial skin from countries of contrasting skin cancer risk

Nature Genetics - A comparison of somatic mutations in skin from individuals from the UK and Singapore suggests that the difference in cancer incidence between the two countries is due to markedly...

www.nature.com

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Kamila Naxerova

@naxerova

9 months

Interesting study! Bonus: I have often seen ribosomal proteins mutated in cancer and didn’t quite know what to make of it, now I know -> disrupts nucleolar stress-induced stabilisation of p53

Convergent somatic evolution commences in utero in a germline ribosomopathy

Nature Communications - Shwachman-Diamond Syndrome (SDS) is an inherited ribosome assembly disorder that increases the risk for haematopoietic malignancies. Here, the authors analysed clonal...

www.nature.com

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Kamila Naxerova

@naxerova

10 months

Padam, padam. And I can tell that you're all in, cause I can hear your heart beatin' But only if you don't have too many recruited macrophages in there! Check out our new paper, a great collaboration with @MatthiasNahrend 's lab:

Kylie Minogue - Padam Padam (Official Video)

The official video for Padam Padam by Kylie Minogue. Listen/save Padam Padam here: https://Kylie.lnk.to/PadamPadamID The new album Tension is out now: https:...

www.youtube.com

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Kamila Naxerova

@naxerova

3 years

Check out our new pre-print on interpretable machine learning models for understanding drug synergy in AML! Wonderful collaboration with @suinleelab , tweetorial by star MD/PhD student @joejanizek below 👇

Joseph D. Janizek

@joejanizek

3 years

Excited that our new pre-print on building interpretable machine learning models to help pick synergistic combinations of anti-cancer drugs for acute myeloid leukemia is out now! @suinleelab @naxerova

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Kamila Naxerova

@naxerova

4 years

New perspective by Christoph Klein, one of the boldest and most original thinkers in metastasis research! Often controversial, always thought-provoking, always deeply considered.

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Kamila Naxerova

@naxerova

4 years

Finally found time to read this paper in detail and it's just mind-blowing. Science nirvana.

Pervasive lesion segregation shapes cancer genome evolution

Nature - Mutagenic lesions such as those that give rise to cancer frequently segregate—unrepaired—during cell division, resulting in phasing of multiple alleles across generations of...

www.nature.com

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Kamila Naxerova

@naxerova

5 years

Much of US science is fueled by hard hard work from foreign scientists, many of them Chinese. Let’s make sure everyone is treated fairly and according to transparent, predetermined rules. In that quintessential American spirit: happy July 4th!

Eric Topol

@EricTopol

5 years

The former @NIH Director, Elias Zerhouni, taking on the targeting of Chinese scientists "The US relies heavily on attracting the best and brightest in the world..." "..serve short-term security concerns at the expense of long-term national interests." +1

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Kamila Naxerova

@naxerova

5 months

Look what is now possible thanks to the fearless, brave antigen explorer Mo Dezfulian from the @elledge_stephen lab! Congratulations! 🥳

TScan-II: A genome-scale platform for the de novo identification of CD4+ T cell epitopes

TScan-II is a genome-scale platform that integrates endogenous antigen processing and T cell signaling, facilitating multiplex screens for the identification of physiologically relevant antigens...

www.cell.com

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Kamila Naxerova

@naxerova

2 years

@Zhu_Lab I do not dare to enter the lab. Too often it has happened that a content trainee innocently browsing Instagram has almost fallen off the chair in shock when I appeared. I do not wish to cause such stress and make my appearances via Slack now. 😆

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Kamila Naxerova

@naxerova

2 years

Whaaaa B cells make acetylcholine to regulate hematopoiesis, these little control freaks??? Please read more below! Happy to have contributed to this great collaboration led by @MatthiasNahrend and his team at @MGHCSB @MGH_RI .

Matthias Nahrendorf stands with Israel

@MatthiasNahrend

2 years

Fresh out @NatImmunol : In the hematopoietic niche, B lymphocytes produce the neurotransmitter acetylcholine thus reducing white blood cell production. 👇

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Kamila Naxerova

@naxerova

1 year

In contrast to somatic mutation rates as shown by @ATJCagan , germline mutation rates are not significantly associated with lifespan. Fascinating paper, cannot wait to dig in!

Evolution of the germline mutation rate across vertebrates

Nature - Using sequencing and comparing high-coverage genomes, the germline mutation rates across vertebrates are quantified.

www.nature.com

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Kamila Naxerova

@naxerova

4 years

I don’t think I would be able to hire anybody at all if J-1 visas were suspended. I don’t receive any applications from American grad students or postdocs. Very grateful to the American government for funding my research, but without these visas I cannot spend the money.

Soumya Raychaudhuri সৌম্য রায়চৌধুরী

@soumya_boston

4 years

Labs (including mine) at @harvardmed , @broadinstitute , other academic institutions benefit so much from scientists on student+work visas. US work fighting COVID-19 today is being done in academia and industry by many currently/previously on these visas.

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Kamila Naxerova

@naxerova

2 years

Please check out Alex's paper here: and @OVincze_ 's paper on zoo animals here: So many fascinating insights in one place! (2/2)

Cancer risk across mammals

Nature - An analysis of cancer mortality data for zoo mammals highlights marked differences across mammalian orders and an influence of diet, and shows that mortality risk is largely independent of...

www.nature.com

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Kamila Naxerova

@naxerova

4 years

Mathematical model of colorectal cancer initiation | Proceedings of the National Academy of Sciences

Quantifying evolutionary dynamics of cancer initiation and progression can provide insights into more effective strategies of early detection and t...

www.pnas.org

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Kamila Naxerova

@naxerova

1 year

Extremely interesting. Clonal dynamics after allogeneic haematopoietic cell transplantation using genome-wide somatic mutations | Research Square

Clonal dynamics after allogeneic haematopoietic cell transplantation using genome-wide somatic...

Allogeneic haematopoietic cell transplantation (HCT) replaces the stem cells responsible for blood production with those harvested from a donor, and is received by 40,000 patients worldwide each...

www.researchsquare.com

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Kamila Naxerova

@naxerova

3 years

Very cool new results fresh off Biorxiv! Greater speed of hematopoietic clone growth in humans is associated with CVD risk factors (insulin resistance & low HDL-C). Further evidence to suggest that CVD drives somatic evolution and #clonalhematopoiesis

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Kamila Naxerova

@naxerova

3 years

Are you interested in genetics, somatic evolution, cancer initiation, metastasis emergence? Do you love to analyze complex data, digging as deeply as you can? We are hiring people with quantitative skills at all levels, please reach out via email.

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Kamila Naxerova

@naxerova

3 years

A wonderful editorial by @UCLA ’s Aldons Lusis on our recent paper linking tissue turnover rates in the hematopoietic system to the rate of #clonalhematopoiesis emergence. Thank you! A vicious cycle in atherosclerosis: Cell

A vicious cycle in atherosclerosis

Clonal hematopoiesis, defined as the presence of expanded somatic blood cell clones, is associated with about a doubling in the risk of coronary heart disease in humans. Heyde and colleagues now...

www.cell.com

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Kamila Naxerova

@naxerova

2 years

Such a good idea! Investigating the roots of concepts that we use in our work every day (often without questioning them sufficiently) is so important. Looking forward to this series.

Nature Genetics

@NatureGenet

2 years

Our sister journal @NatureRevGenet now publishes #JournalClub articles, in which authors explore historical scientific publications that have inspired them: This editorial explains a bit more about this article type:

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Kamila Naxerova

@naxerova

2 years

Thank you @TheMarkFdn !! To everybody reading this: I highly recommend applying for the Emerging Leader Award, it’s such a wonderful inspiring funding mechanism, very efficient and values all the right things!

The Mark Foundation for Cancer Research

@TheMarkFdn

2 years

For #ColorectalCancerAwarenessMonth we’re spotlighting 2022 Emerging Leader Awardee Kamila Naxerova’s research Towards an “earliest detection” assay for early-onset colorectal cancer @naxerova @MGHCSB @MGH_RI 2023 ELA applications are open see link below!

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Kamila Naxerova

@naxerova

3 years

@pedrosaurio @epigenetichulk The Epigenetic Hulk is who he is, you cannot ask him stuff like “why the anger”. That is like asking a bird “why do you fly”?

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Kamila Naxerova

@naxerova

6 months

Just saw this work at #EMBLCanGen and two seconds later it’s already a pre-print! Super interesting stuff, everyone should read & think.

Andrea Sottoriva

@AndreaSottoriva

6 months

Is #cancer drug resistance heritable or plastic? Genetic or non-genetic? How do we tell those apart? We just begun measuring the temporal dynamics of evolving cancers using controllable patient-derived #organoids . We need more experiments+theory!

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Kamila Naxerova

@naxerova

4 years

Sadly even during this (physically) lazy time, my brilliant @MGH_RI @MGHCSB colleagues cannot help but remind me to exercise. Read this interview with @MatthiasNahrend to boost your motivation! Stem cell activity linked to lifestyle | Harvard Magazine

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Kamila Naxerova

@naxerova

3 years

All by similar mechanism? Infection/IFNg -> HSC proliferation -> CH Atherosclerosis -> HSC proliferation -> CH Sleep deprivation -> HSC proliferation -> CH

Matthias Nahrendorf stands with Israel

@MatthiasNahrend

3 years

Fantastic work published in @CellStemCell rigorously showing that infection (and IFNg) cause clonal hematopoiesis: Just like atherosclerosis or sleep deprivation cause clonal hematopoiesis: All 👀 on the 🦴 marrow!

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Kamila Naxerova

@naxerova

3 years

Gorgeous phylogenetic trees in a new Gut paper from Chen at al.! Show the same fascinating pattern we observed with @jgreiter last year: lymph node mets essentially indistinguishable from the prim. tumor & phylogenetically so different from distant mets.

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Kamila Naxerova

@naxerova

3 years

This is a wonderful idea. Let’s start a “classic papers in somatic evolution” Twitter journal club! Reading classic literature is so enriching. I always realize... most things have been known for a long time. All we need to do is look them up!

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Kamila Naxerova

@naxerova

5 years

Monday night in the Naxerova lab, at the local joint, 5 min from the lab. Come do your postdoc with us if you are interested in tumor evolution and stunning views!

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Kamila Naxerova

@naxerova

2 years

Very cool set of color-tagging experiments by @SwirskiLab and @cam_phd showing how increased HSC proliferation in mice (here: caused by sleep deprivation) accelerates genetic drift, leading to greater genetic homogeneity in sleep-deprived mousies over time. 🐭🥱😴😢

Fil Swirski & Scientists

@SwirskiLab

2 years

Excited to share our latest on sleep & hematopoiesis. Data in humans & mice. Great collab w/ @MPStOngePhD @naxerova @ScaddenLab @MatthiasNahrend @cam_phd Sleep exerts lasting effects on hematopoietic stem cell function and diversity

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Kamila Naxerova

@naxerova

3 years

Finally got around to reading this paper in detail. Such clear and elegant work. The logic is undeniable - this must be how CRC initiation works. @IBozic_ , now please invent a drug to kill off all APC mutants that we can take every 5-10 years?

Mathematical model of colorectal cancer initiation | Proceedings of the National Academy of Sciences

Quantifying evolutionary dynamics of cancer initiation and progression can provide insights into more effective strategies of early detection and t...

www.pnas.org

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Kamila Naxerova

@naxerova

2 years

The first commandment of bioinformatics.

Mick W@tson ↙️

@BioMickWatson

2 years

@nilshomer Visualise *everything* Look at sequence reads, sequence assemblies, data, alignments, SNPs, PCA all of your numerical data. Get into the *details* of your data

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Kamila Naxerova

@naxerova

5 months

I love this paper and I think it was well worth the 10 or so years it was in production 🤣

Matthias Nahrendorf stands with Israel

@MatthiasNahrend

5 months

Special thanks to @naxerova who never stopped believing in this story 👍🏻

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Kamila Naxerova

@naxerova

3 years

@OdedRechavi

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Kamila Naxerova

@naxerova

8 months

I think we have to take the long view here. Newton also did not immediately start building a rocket after the apple woke him up from his nap. 😚

Florian Markowetz

@markowetzlab

8 months

I completely agree - exactly what I see in cancer. So much work on phylogenies, clonal expansions, subclonal drivers - all great science. And useless when treating patients.

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Kamila Naxerova

@naxerova

6 years

Metastases are already seeded by the time the primary tumor acquires driver diversity! Very good news for diagnosis and treatment, and a deep insight into tumor evolution dynamics. Great job yet again @jgreiter and @DrMANowak !

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Kamila Naxerova

@naxerova

3 years

Looking forward to diving into this one. Extremely important and interesting topic.

The evolution of hematopoietic cells under cancer therapy

Nature Communications - The mutational effects of chemotherapies on healthy cells are unclear. Here, the authors show that the mutational signature of platinum-based drugs -but not 5-fluorouracil-...

www.nature.com

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Kamila Naxerova

@naxerova

2 years

Congratulations to our very own @alexgorelick , co-supervised by @getz_lab , who won a fabulous LSRF @LSRFdtn postdoc fellowship, sponsored by the MacMillan Family Foundation! Alex will figure out the deep dark nature of metastasis founder clones!

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Kamila Naxerova

@naxerova

2 years

New review from Phil Jones, reigning king of epithelia, in @CD_AACR Somatic mutation: What shapes the mutational landscape of normal epithelia?

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Kamila Naxerova

@naxerova

5 years

Great collaboration with some of my favorite people in the world, Alex Heyde, @jgreiter and @DrMANowak !

Martin A. Nowak

@DrMANowak

5 years

In our new paper, just out in PNAS, we derive a surprisingly simple formula that relates the expected diversity of a metastasis to the diversity in the pool of seeding cells. Alex Heyde @jgreiter @naxerova

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Kamila Naxerova

@naxerova

2 years

Excited to read this.

Cancer stem cells: The adventurous journey from hematopoietic to leukemic stem cells

This year’s Gairdner Foundation Award for Biomedical Research is awarded to John Dick for the discovery of leukemic stem cells and the hierarchical organization of acute myeloid leukemias. His work...

www.cell.com

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Kamila Naxerova

@naxerova

2 years

Very interesting data set, hat tip ⁦⁦ @mathoncbro . I wish there were many more studies on metastasis growth rates in different host organs. These data exist and would be such an important complement to genetic studies. Pointers very welcome!

The Macroscopic Growth Laws of Brain Metastases

Tumor growth is the result of the interplay of complex biological processes in a huge number of individual cells in a changing environment. Effective simple mathematical laws have been shown to...

www.medrxiv.org

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Kamila Naxerova

@naxerova

2 years

Woah

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Kamila Naxerova

@naxerova

5 years

Exercise reduces cardiovascular disease by modulating hematopoietic activity - new study by @MatthiasNahrend and friends at @MGHCSB and @harvardmed , out now in @NatureMedicine . Read & weep and then run - no more excuses, even for couch potatoes like me!

Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of...

Nature Medicine - The beneficial effects of exercise on cardiovascular disease are linked to decreased inflammation through crosstalk between adipose tissue and hematopoietic progenitor cells in...

www.nature.com

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Kamila Naxerova

@naxerova

2 years

All I want for Christmas … 🌲🎼🎻🥂🍾 … is a better understanding of cardiovascular disease’s impact on the bone marrow! Thank you Santa @MatthiasNahrend & Nahrendorf lab elves for this fabulous present, delivered just in time!

Matthias Nahrendorf stands with Israel

@MatthiasNahrend

2 years

Out in @NatureCVR from @MGHCSB @MGH_RI : CardioVASCULAR disease affects the bone marrow’s VASCULAR blood stem cell niche, ramping up leukocyte production. Hypertension, athero and MI act on marrow endothelial cells, changing vascular anatomy & function.

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Kamila Naxerova

@naxerova

3 years

Our results + previous studies by @jaiswalmdphd et al. and @josejfuster et al. indicate that patients suffer from a vicious circle. Athero -> CH -> Athero -> CH etc.

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Kamila Naxerova

@naxerova

5 years

@JennyLeeHowell @tuuliel Or maybe it’s just a way for awkward academics who want to be nice and make friends with you to engage in small talk. I think one is always better off assuming good intentions in people. I am cringing thinking back at some of my own failed attempts at small talk...

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Kamila Naxerova

@naxerova

3 years

Many say that getting proofs is the best moment in the publishing process. I disagree! Finishing the final draft of a paper after struggling with it for - invariably - YEARS is my favorite moment. Like Sisyphus being told that he can pause and have a sip of high-end Tequila.

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Kamila Naxerova

@naxerova

3 years

Looking forward to this wonderful symposium on metastasis biology, featuring many admired colleagues - please see below for schedule and registration info.

richard white

@whitefishlab

3 years

Upcoming (virtual) symposium on basic mechanisms of metastasis! Organized by @SwarnaliAchary5 and Carol Prives @Columbia . Amazing lineup of speakers and topics - should be really excellent - registration info below.

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Kamila Naxerova

@naxerova

2 years

Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps: Cell

Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in...

A single-cell resolution atlas of human colorectal polyps maps out distinct paths for pre-cancer to cancer transformation, accompanied by differential immune microenvironment features.

www.cell.com

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Kamila Naxerova

@naxerova

4 years

Please join us for a special seminar on explainable artificial intelligence in medicine by @suinleelab next Monday, December 2nd, 9:30 AM at MGH/Simches. Su-In is a great speaker - can't wait! @MGHCSB @MGH_RI #ArtificialIntelligence #DataScience

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Kamila Naxerova

@naxerova

4 years

The master himself at the bench! It’s like Darwin is out in the field catching finches! ☺️

Matthias Nahrendorf stands with Israel

@MatthiasNahrend

4 years

I embedded 8 specimen today (aortic roots). Fingers crossed the orientation is proper and all 3 leaflets are visible! Thanks ⁦ @naxerova ⁩ and ⁦ @shuangzhang_ ⁩ for trusting me old hand with your experiment 😊

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Kamila Naxerova

@naxerova

2 years

The wondrous EBV/MS journey continues!

Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM

Nature - The identification of high-affinity molecular mimicry between the Epstein–Barr virus (EBV) transcription factor EBNA1 and the CNS protein GlialCAM provides a mechanistic link between...

www.nature.com

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Kamila Naxerova

@naxerova

1 year

Very interesting and important. I always somehow resented the idea that Franklin was a hapless victim of Watson & Crick's ambitions. She knew they would see her data and was cool with it. An attitude worthy of a great intellectual!

Matthew Cobb

@matthewcobb

1 year

70 years ago, 3 papers appeared in @Nature under the title ‘Molecular structure of nucleic acids’. In an article in Nature today (link at end) @nccomfort and I shed new light on ‘what Watson and Crick really took from Rosalind Franklin’. This thread summarises our findings. 1/23

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Kamila Naxerova

@naxerova

3 years

Absolutely loved this paper. Independent somatic evolution underlies clustered neuroendocrine tumors in the human small intestine | Nature Communications

Independent somatic evolution underlies clustered neuroendocrine tumors in the human small intestine

Nature Communications - Small intestine neuroendocrine tumors (SI-NETs) are frequently multifocal and metastatic, but their tumourigenesis is still poorly understood. Here, the authors analyse...

www.nature.com

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Kamila Naxerova

@naxerova

3 years

Major congratulations @Bartomeu_Colom and team!! Looking forward to reading the new version, we already lovingly studied the preprint in journal club. 🥰

Bartomeu Colom

@Bartomeu_Colom

3 years

Out today @Nature ! Human tissues accumulate cancer-driver mutations with age, yet tumor formation remains rare, why!? We show that mutant clones in the normal epithelium can have a tumor-protective role by outcompeting and eliminating nascent tumors.

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Kamila Naxerova

@naxerova

1 year

Excited for this joint project with @joejanizek and @suinleelab to be published. I learned so much working on this paper!

Su-In Lee

@suinleelab

1 year

Finally published! 🥳🎉 Explainable AI has revealed that hematopoietic differentiation is a crucial indicator for identifying anti-cancer drug synergies in acute myeloid leukemia.

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Kamila Naxerova

@naxerova

5 years

So cool! Is there a purpose to this movement? Or just the heritage of a wiggly prokaryotic past?

Dylan Burnette

@MAG2ART

5 years

THE CELL’S POWERHOUSE Mitochondria (yellow) make much of the chemical energy that fuels the life of a cell. They also move rapidly as seen in this cancer cell compared to the relatively slow moving nucleus (blue) and cellular adhesions (purple). #MitoMonday #CellBiology

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Kamila Naxerova

@naxerova

1 year

Very interesting study. Evolutionary route of nasopharyngeal carcinoma metastasis and its clinical significance | Nature Communications

Evolutionary route of nasopharyngeal carcinoma metastasis and its clinical significance

Nature Communications - It is critical to understand the factors that are associated with nasopharyngeal carcinoma (NPC) progression, metastasis and response to therapy. Here, the authors analyse...

www.nature.com

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Kamila Naxerova

@naxerova

6 years

Congrats on this groundbreaking work!!! @jgreiter @DrMANowak @ciacobu

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Kamila Naxerova

@naxerova

4 years

Wow incredible! Gives a whole new meaning to “interdisciplinary”! I will be very very careful when using that word from now on.

Oded Rechavi

@OdedRechavi

4 years

Here’s a wild story on how we tried to piece the Dead Sea Scrolls “puzzle” by sequencing ancient DNA extracted from the animal skins on which the scrolls were written. Please read the @CellCellPress paper, retweet and checkout my short thread👇

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Kamila Naxerova

@naxerova

4 years

After a long, exhausting 2019, burning the candle from both ends and trying to build a lab, I am now looking ahead to 2020 and strangely the main question occupying my mind is: Are Beethoven, John Lennon and Dr. Dre essentially the same person?

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Kamila Naxerova

@naxerova

5 years

Congratulations @pavitra451 ! Single author Nature paper in grad school, what a sight to behold! 🥇

Pavitra Muralidhar

@pavitra451

5 years

I'm excited to share my paper on the mating preferences of selfish sex chromosomes, now online at Nature! This will be a short thread on the main results. 1/

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Kamila Naxerova

@naxerova

6 years

We are looking for another postdoc to join our growing team! If you are interested in cancer (phylo-) genetics and tumor evolution, please consider applying -- we are very friendly, motivated and loooove science!

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Kamila Naxerova

@naxerova

7 months

We are of course hiring! If you are interested in somatic evolution (normal tissue evolution, carcinogenesis, metastasis development) *in humans*, please reach out. New lab website is on the way and only delayed by my personal slowness. Old website in bio still accurate though.

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Kamila Naxerova

@naxerova

4 years

Super review on lymphatics by @LabRandolph and friends!

Cell

@CellCellPress

4 years

New review out now! #Asymptomatic alterations in lymphatic #vascular function could underlie the variability seen in the #body ’s response to a wide range of #human #diseases . @NU_Lymphatics

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Kamila Naxerova

@naxerova

5 years

*THUNDER* The ⁦ @SwirskiLab ⁩ strikes again! ⚡️ Sleep modulates haematopoiesis and protects against atherosclerosis | Nature

Sleep modulates haematopoiesis and protects against atherosclerosis

Nature - The fragmentation of sleep in Apoe−/− mice induces monocytosis and accelerated atherosclerosis due to a reduction in hypocretin that otherwise restricts bone marrow CSF1...

www.nature.com

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Kamila Naxerova

@naxerova

5 years

Amazing new insights from ⁦ @SwirskiLab ⁩! Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease | Nature

Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease

Nature - Integrin β7-dependent Glp1rhigh natural gut intraepithelial T lymphocytes that reside in the small intestine modulate dietary metabolism in mice by restricting the bioavailability of...

www.nature.com

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Kamila Naxerova

@naxerova

5 years

Brief shout-out to a paper I really admired - perfect union of both human and mouse worlds. Somatic mutations are improving their bad rap | Science Translational Medicine

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Kamila Naxerova

@naxerova

2 years

Such an important piece. Couldn’t agree more with ⁦⁦ @DrSidMukherjee ⁩’s sentiment here. New cancer diagnostics will save lives, writes Siddhartha Mukherjee, but they risk turning all of us into anxious ‘previvors.’

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Kamila Naxerova

@naxerova

5 years

Hm this sounds nice... Senate committee recommends $3 billion increase for NIH funding

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Kamila Naxerova

@naxerova

3 years

Emerging strategies for treating metastasis

Nature Cancer - Kang and colleagues review recent advances and challenges in developing therapies for metastatic cancer and the clinical implications of ongoing and completed studies for metastatic...

www.nature.com

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Kamila Naxerova

@naxerova

3 years

What a smart, thoughtful and balanced perspective on the causal connections between #clonalhematopoiesis and #atherosclerosis . Thank you @fsanchezcabo and @josejfuster ! Hope to discuss this fascinating topic with you in person at some point!

Clonal haematopoiesis and atherosclerosis: a chicken or egg question?

Nature Reviews Cardiology - Sequencing studies demonstrate a strong clinical association between clonal haematopoiesis driven by acquired mutations and atherosclerotic disease. Previous research...

www.nature.com

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Kamila Naxerova

@naxerova

3 years

Looking forward to reading this paper. I suspect it will do me no harm to stop thinking obsessively about cancer cell genetics for a moment and consider the existence of other cells. 😊

Gut vascular barrier impairment leads to intestinal bacteria dissemination and colorectal cancer...

Bertocchi et al. demonstrate the critical role of the gut vascular barrier (GVB) in the hematogenous route of liver CRC metastases. They link GVB impairment with bacteria translocation into the...

www.cell.com

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Kamila Naxerova

@naxerova

4 years

Thanks so much and congratulations on this amazing piece of work @Bartomeu_Colom @MariaPAlcolea @MoritzGerstung @imartincorena @Hall_b_a and all others!

Bartomeu Colom

@Bartomeu_Colom

4 years

Fantastic comments on our paper by @naxerova at @NatureGenet

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Kamila Naxerova

@naxerova

8 months

Looking forward to this great event which also takes home the prize for coolest conference name!

mutationmeeting

@mutationmeeting

8 months

Registration is now open for our Mutations in Time and Space conference! The meeting will run over 23-25 April 2024 in Edinburgh, UK, and will focus on mutational processes evident across various biological scales.

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Kamila Naxerova

@naxerova

2 years

This is such an endearing article. "On any given day, Huh does about three hours of focused work. [...] 'Then I’m exhausted,' he said." Everybody knows that quantity != quality, but this is a particularly powerful illustration.

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Kamila Naxerova

@naxerova

4 years

Fantastic News & Views on our recent metastasis heterogeneity paper- thank you @trevoragraham and Darryl Shibata!

Johannes Reiter

@jgreiter

4 years

Very cool discussion of the phenotype and timing of distant metastasis related to our new paper by @trevoragraham and Darryl Shibata. Thank you for putting our work into context: @naxerova

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Kamila Naxerova

@naxerova

2 years

Fun!!!!! I tried this with the title of my last paper and it worked shockingly well. “Integrated loss- and gain-of-function screens define a core network governing human embryonic stem cell behavior.”

Seven Machina Rasmussen

@toomanyspectra

2 years

fun prompt: put the title of your graduate thesis into this app and see what kind of art it creates

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